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You searched for: Subject term alginates Remove constraint Subject term: alginates Subject term angiogenesis Remove constraint Subject term: angiogenesis Subject term collagen Remove constraint Subject term: collagen
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1. Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis

Author:
A.L. Torres; S.J. Bidarra; M.T. Pinto; P.C. Aguiar; E.A. Silva; C.C. Barrias
Source:
Biomaterials 2017 pp. -
ISSN:
0142-9612
Subject:
alginates; angiogenesis; biomechanics; chickens; chicks; collagen; endothelial cells; extracellular matrix; fibronectins; humans; morphogenesis; normoxia; peptides; stem cells
Abstract:
... Efficient cell delivery strategies are urgently needed to improve the outcome of cell-based pro-angiogenic therapies. This study describes the design of an injectable cell delivery platform, based on biomaterial-guided morphogenesis principles. Soft high-mannuronic acid alginate microgels, oxidized and functionalized with integrin-binding peptides, provided adequate biochemical/biomechanical cues ...
DOI:
10.1016/j.biomaterials.2017.10.051

2. Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound

Author:
Zefeng Lin; Tingting Wu; Wanshun Wang; Binglin Li; Ming Wang; Lingling Chen; Hong Xia; Tao Zhang
Source:
International journal of biological macromolecules 2019 v.140 pp. 330-342
ISSN:
0141-8130
Subject:
Escherichia coli; alginates; angiogenesis; antibiotic resistance; antibiotics; antimicrobial peptides; antimicrobial properties; biodegradability; collagen; drugs; fibroblasts; hyaluronic acid; mechanical properties; methicillin-resistant Staphylococcus aureus; porosity; silver; tissue repair
Abstract:
... The increase in severe infections caused by antibiotic drug resistance and the decrease in the number of new antibacterial drugs approved for use in the last few decades are driving the need for the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) are a potential new class of antimicrobial drugs that are expected to solve the problem of global antibiotic drug resistance. ...
DOI:
10.1016/j.ijbiomac.2019.08.087

3. Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds

Author:
Nurhasni Hasan; Juho Lee; Dongmin Kwak; Hyunwoo Kim; Aruzhan Saparbayeva; Hye-Jin Ahn; In-Soo Yoon; Min-Soo Kim; Yunjin Jung; Jin-Wook Yoo
Source:
Carbohydrate polymers 2021 v.270 pp. 118387
ISSN:
0144-8617
Subject:
alginates; angiogenesis; antibacterial properties; bacterial infections; collagen; fibroblasts; histology; hydrogels; inflammation; methicillin-resistant Staphylococcus aureus; mice; nitric oxide; toxicity
Abstract:
... This study demonstrates the development of a nitric oxide (NO)-releasing hydrogel wound dressing and its efficacy at accelerating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. A DETA/NONOate-doped alginate (Alg-DETA/NO) hydrogel was synthesized using alginate as a hydrogel-forming wound dressing material and diethylenetriamine/diazeniumdiolate (DETA/NONOate) as an NO d ...
DOI:
10.1016/j.carbpol.2021.118387

4. Fabrication and characterization of Chrysin – A plant polyphenol loaded alginate -chitosan composite for wound healing application

Author:
Pallavi Shyam Kaparekar; Nidhi Poddar; Suresh Kumar Anandasadagopan
Source:
Colloids and surfaces 2021 v.206 pp. 111922
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; alginates; angiogenesis; biocompatibility; biodegradation; blood; cell growth; cell movement; cell proliferation; chrysin; collagen; drugs; electron microscopy; fibroblasts; freeze drying; hexosamines; lysozyme; polyphenols; porosity; propidium; sodium; thermal stability; thermogravimetry; wound treatment
Abstract:
... The present study explores the therapeutic efficacy of sodium alginate-chitosan scaffolds loaded with Chrysin (ALG-CS-CHY) for dermal wound management. Scaffolds were prepared by the vacuum freeze-drying method. The physiochemical characterization was done through Fourier Transform Infra-Red Spectroscopy (FTIR), which revealed the interactions between the scaffold's functional groups and the drug. ...
DOI:
10.1016/j.colsurfb.2021.111922

5. Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Author:
Eamon J. Sheehy; Gregory J. Miller; Isabel Amado; Rosanne M. Raftery; Gang Chen; Kai Cortright; Arlyng Gonzalez Vazquez; Fergal J. O'Brien
Source:
Journal of controlled release 2021 v.334 pp. 96-105
ISSN:
0168-3659
Subject:
alginates; angiogenesis; bone formation; collagen; dose response; genes; hydroxyapatite; medicine; placental growth factor; rats; therapeutics
Abstract:
... Leveraging the differential response of genes to mechanical loading may allow for the identification of novel therapeutics and we have recently established placental growth factor (PGF) as a mechanically augmented gene which promotes angiogenesis at higher doses and osteogenesis at lower doses. Herein, we sought to execute a mechanobiology-informed approach to regenerative medicine by designing a ...
DOI:
10.1016/j.jconrel.2021.03.031