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You searched for: Subject term alginates Remove constraint Subject term: alginates Subject term angiogenesis Remove constraint Subject term: angiogenesis
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1. A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis

Author:
Xuxiu Lu; Ling Qin; Meng Guo; Jiajia Geng; Songtao Dong; Kai Wang; Hui Xu; Changfeng Qu; Jinlai Miao; Ming Liu
Source:
Carbohydrate polymers 2022 v.289 pp. 119437
ISSN:
0144-8617
Subject:
Sargassum; alginates; angiogenesis; diabetes; drugs; glucuronic acid; inflammation; macroalgae; models; oxidative stress; therapeutics; vascular endothelial growth factors
Abstract:
... Diabetic skin ulcer is one of the most severe complications in diabetes, however, current therapeutic approaches are not effective enough. Agents modulating oxidative stress, inflammation, and angiogenesis are quite promising for alleviation of diabetic skin ulcers. In this study, a novel Sargassum kjellmanianum-derived polysaccharide (SARP) was prepared. SARP was an alginate with Mw of 45.4 kDa, ...
DOI:
10.1016/j.carbpol.2022.119437

2. Brown seaweeds as a source of anti-hyaluronidase compounds

Author:
K. Arunkumar; Reeshma Raj; Rathinam Raja; Isabel S Carvalho
Source:
South African journal of botany 2021 v.139 pp. 470-477
ISSN:
0254-6299
Subject:
Eisenia arborea; N-acetylglucosamine; Sargassum; alginates; angiogenesis; antioxidants; botany; fucoidan; hyaluronic acid; hyaluronoglucosaminidase; inflammation; metastasis; neoplasms; phlorotannins; sulfates; thallus; viscosity
Abstract:
... Hyaluronidase enzymes disrupt hyaluronic acid, causing angiogenesis, tumor invasiveness, metastasis, inflammation, and skin aging. Phlorotannin, alginate and fucoidan were extracted successively from the blade and stipe samples of two Sargassum seaweeds and Eisenia arborea thallus. These were evaluated for their in vitro anti-hyaluronidase and antioxidant activities (DPPH and reducing power assay) ...
DOI:
10.1016/j.sajb.2021.03.036

3. Chitosan/Hyaluronic acid/Alginate and an assorted polymers loaded with honey, plant, and marine compounds for progressive wound healing—Know-how

Author:
Murugan Prasathkumar; Subramaniam Sadhasivam
Source:
International journal of biological macromolecules 2021 v.186 pp. 656-685
ISSN:
0141-8130
Subject:
alginates; amputation; andrographolide; angiogenesis; biocompatibility; biocompatible materials; biodegradability; biofilm; carrageenan; cartilage; cellulose; cellulose acetate; chitin; chitosan; curcumin; fibrin; gelatin; honey; hyaluronic acid; hydrogels; medicine; nanofibers; pullulan; quercetin; risk
Abstract:
... Biomaterials are being extensively used in regenerative medicine including tissue engineering applications, as these enhance tissue development, repair, and help in the process of angiogenesis. Wound healing is a crucial biological process of regeneration of ruptured tissue after getting injury to the skin and other soft tissue in humans and animals. Besides, the accumulation of microbial biofilms ...
DOI:
10.1016/j.ijbiomac.2021.07.067

4. Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Author:
Canran Wang; Xing Jiang; Han-Jun Kim; Shiming Zhang; Xingwu Zhou; Yi Chen; Haonan Ling; Yumeng Xue; Zhaowei Chen; Moyuan Qu; Li Ren; Jixiang Zhu; Alberto Libanori; Yangzhi Zhu; Heemin Kang; Samad Ahadian; Mehmet R. Dokmeci; Peyman Servati; Ximin He; Zhen Gu; Wujin Sun; Ali Khademhosseini
Source:
Biomaterials 2022 v.285 pp. 121479
ISSN:
0142-9612
Subject:
alginates; angiogenesis; animal models; biocompatible materials; cell proliferation; electrical treatment; electrodes; hydrogels; immune response; nanowires; secretion; silver; wound treatment
Abstract:
... Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydro ...
DOI:
10.1016/j.biomaterials.2022.121479

5. Alginic acid inhibits non-small cell lung cancer-induced angiogenesis via activating miR-506 expression

Author:
Keping Wang; Bin Wang; Zunqiao Wang; Rusong Yang
Source:
Natural medicines 2021 v.75 no.3 pp. 553-564
ISSN:
1340-3443
Subject:
alginates; angiogenesis; cytokines; humans; lung neoplasms; lungs; neoplasm progression; non-coding RNA; oral administration; transcription (genetics); vascular endothelial growth factor A; xenotransplantation
Abstract:
... Angiogenesis is a key event in non-small cell lung cancer progression. Alginic acid (AA), a kind of naturally occurring polyuronic acid, is generally enriched in edible brown algae. Recent studies have uncovered its anti-anaphylactic and anti-inflammatory properties. However, the effects of AA on human malignancies remain unknown. Herein, efficient inhibition of AA on NSCLC-induced angiogenesis wa ...
DOI:
10.1007/s11418-021-01493-2

6. Aligned Graphene Mesh-Supported Double Network Natural Hydrogel Conduit Loaded with Netrin-1 for Peripheral Nerve Regeneration

Author:
Qun Huang; Yuting Cai; Xing Zhang; Junchao Liu; Zhenjing Liu; Bo Li; Hoilun Wong; Feng Xu; Liyuan Sheng; Dazhi Sun; Jinbao Qin; Zhengtang Luo; Xinwu Lu
Source:
ACS applied materials & interfaces 2021 v.13 no.1 pp. 112-122
ISSN:
1944-8252
Subject:
alginates; axons; biocompatibility; electrical conductivity; graphene; hydrogels; muscles; nerve regeneration; nerve tissue; strength (mechanics); therapeutics; ultraviolet radiation
Abstract:
... The gold standard treatment for peripheral nerve injuries (PNIs) is the autologous graft, while it is associated with the shortage of donors and results in major complications. In the present study, we engineer a graphene mesh-supported double-network (DN) hydrogel scaffold, loaded with netrin-1. Natural alginate and gelatin-methacryloyl entangled hydrogel that is synthesized via fast exchange of ...
DOI:
10.1021/acsami.0c16391

7. Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds

Author:
Nurhasni Hasan; Juho Lee; Dongmin Kwak; Hyunwoo Kim; Aruzhan Saparbayeva; Hye-Jin Ahn; In-Soo Yoon; Min-Soo Kim; Yunjin Jung; Jin-Wook Yoo
Source:
Carbohydrate polymers 2021 v.270 pp. 118387
ISSN:
0144-8617
Subject:
alginates; angiogenesis; antibacterial properties; bacterial infections; collagen; fibroblasts; histology; hydrogels; inflammation; methicillin-resistant Staphylococcus aureus; mice; nitric oxide; toxicity
Abstract:
... This study demonstrates the development of a nitric oxide (NO)-releasing hydrogel wound dressing and its efficacy at accelerating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. A DETA/NONOate-doped alginate (Alg-DETA/NO) hydrogel was synthesized using alginate as a hydrogel-forming wound dressing material and diethylenetriamine/diazeniumdiolate (DETA/NONOate) as an NO d ...
DOI:
10.1016/j.carbpol.2021.118387

8. Fabrication and characterization of Chrysin – A plant polyphenol loaded alginate -chitosan composite for wound healing application

Author:
Pallavi Shyam Kaparekar; Nidhi Poddar; Suresh Kumar Anandasadagopan
Source:
Colloids and surfaces 2021 v.206 pp. 111922
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; alginates; angiogenesis; biocompatibility; biodegradation; blood; cell growth; cell movement; cell proliferation; chrysin; collagen; drugs; electron microscopy; fibroblasts; freeze drying; hexosamines; lysozyme; polyphenols; porosity; propidium; sodium; thermal stability; thermogravimetry; wound treatment
Abstract:
... The present study explores the therapeutic efficacy of sodium alginate-chitosan scaffolds loaded with Chrysin (ALG-CS-CHY) for dermal wound management. Scaffolds were prepared by the vacuum freeze-drying method. The physiochemical characterization was done through Fourier Transform Infra-Red Spectroscopy (FTIR), which revealed the interactions between the scaffold's functional groups and the drug. ...
DOI:
10.1016/j.colsurfb.2021.111922

9. Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Author:
Eamon J. Sheehy; Gregory J. Miller; Isabel Amado; Rosanne M. Raftery; Gang Chen; Kai Cortright; Arlyng Gonzalez Vazquez; Fergal J. O'Brien
Source:
Journal of controlled release 2021 v.334 pp. 96-105
ISSN:
0168-3659
Subject:
alginates; angiogenesis; bone formation; collagen; dose response; genes; hydroxyapatite; medicine; placental growth factor; rats; therapeutics
Abstract:
... Leveraging the differential response of genes to mechanical loading may allow for the identification of novel therapeutics and we have recently established placental growth factor (PGF) as a mechanically augmented gene which promotes angiogenesis at higher doses and osteogenesis at lower doses. Herein, we sought to execute a mechanobiology-informed approach to regenerative medicine by designing a ...
DOI:
10.1016/j.jconrel.2021.03.031

10. Multi-peptide presentation and hydrogel mechanics jointly enhance therapeutic duo-potential of entrapped stromal cells

Author:
Ben P. Hung; Tomas Gonzalez-Fernandez; Jenny B. Lin; Takeyah Campbell; Yu Bin Lee; Alyssa Panitch; Eben Alsberg; J. Kent Leach
Source:
Biomaterials 2020 v.245 pp. 119973
ISSN:
0142-9612
Subject:
adhesion; alginates; angiogenesis; biocompatible materials; bone formation; encapsulation; extracellular matrix; hydrogels; mechanics; mineralization; osteoblasts; peptides; rats; secretion; therapeutics; viscoelasticity
Abstract:
... The native extracellular matrix (ECM) contains a host of matricellular proteins and bioactive factors that regulate cell behavior, and many ECM components have been leveraged to guide cell fate. However, the large size and chemical characteristics of these constituents complicate their incorporation into biomaterials without interfering with material properties, motivating the need for alternative ...
DOI:
10.1016/j.biomaterials.2020.119973
PubMed:
32244091
PubMed Central:
PMC7183241

11. Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment

Author:
Linglan Yang; Leitao Zhang; Jing Hu; Wenjin Wang; Xiqiang Liu
Source:
International journal of biological macromolecules 2021 v.166 pp. 166-178
ISSN:
0141-8130
Subject:
alginates; angiogenesis; biocompatibility; cellulose; fibroblasts; genes; human health; hyaluronic acid; hydrogels; interleukin-6; mice; microparticles; oxidation; schiff bases; strength (mechanics); wound treatment
Abstract:
... Chronic diabetic wound causes serious threat to human health due to its long inflammatory phase and the reduced vascularization. Herein, we develop a hydrogel system for the treatment of diabetic wound, which can short the inflammatory stage (through the use of ori) and promote the angiogenesis (through the addition of siRNA-29a gene). Based on the Schiff base bonds, the Gel/Alg@ori/HA-PEI@siRNA-2 ...
DOI:
10.1016/j.ijbiomac.2020.10.129

12. Tripeptide-based macroporous hydrogel improves the osteogenic microenvironment of stem cells

Author:
Qian Li; He Zhang; Jijia Pan; Binhong Teng; Ziqian Zeng; Yang Chen; Yu Hei; Siqi Zhang; Shicheng Wei; Yuhua Sun
Source:
Journal of materials chemistry B 2021 v.9 no.30 pp. 6056-6067
ISSN:
2050-7518
Subject:
adhesion; alginates; angiogenesis; apoptosis; blood; bone formation; gelatin; humans; hydrogels; hypoxia; microparticles; porous media; silica; tripeptides
Abstract:
... Due to the ability to combine multiple osteogenic induction “cues” at the same time, hydrogels are widely used in the three-dimensional (3D) culture of human mesenchymal stem cells (hMSCs) and osteoinduction. However, the survival and proliferation of stem cells in a 3D culture system are limited, which reduces their osteogenic differentiation efficiency. In addition, the cells inside the hydrogel ...
DOI:
10.1039/d1tb01175h

13. 3D Bioprinting-Tunable Small-Diameter Blood Vessels with Biomimetic Biphasic Cell Layers

Author:
Xuan Zhou; Margaret Nowicki; Hao Sun; Sung Yun Hann; Haitao Cui; Timothy Esworthy; James D. Lee; Michael Plesniak; Lijie Grace Zhang
Source:
ACS applied materials & interfaces 2020 v.12 no.41 pp. 45904-45915
ISSN:
1944-8252
Subject:
actin; alginates; angiogenesis; biomimetics; blood; blood vessels; cell proliferation; encapsulation; endothelial cells; fluid mechanics; gelatin; genes; morbidity; mortality; muscles; risk; smooth muscle; temperature
Abstract:
... Blood vessel damage resulting from trauma or diseases presents a serious risk of morbidity and mortality. Although synthetic vascular grafts have been successfully commercialized for clinical use, they are currently only readily available for large-diameter vessels (>6 mm). Small-diameter vessel (<6 mm) replacements, however, still present significant clinical challenges worldwide. The primary obj ...
DOI:
10.1021/acsami.0c14871

14. Conductive Hydrogen Sulfide-Releasing Hydrogel Encapsulating ADSCs for Myocardial Infarction Treatment

Author:
Wei Liang; Jingrui Chen; Lingyan Li; Min Li; Xiaojuan Wei; Baoyu Tan; Yingying Shang; Guanwei Fan; Wei Wang; Wenguang Liu
Source:
ACS applied materials & interfaces 2019 v.11 no.16 pp. 14619-14629
ISSN:
1944-8252
Subject:
alginates; angiogenesis; echocardiography; encapsulation; gelatin; gene expression regulation; half life; histology; hydrogels; hydrogen; hydrogen sulfide; infarction; laboratory animals; messenger RNA; myocardial infarction; myocardium; neoplasms; rats; schiff bases; stem cells; therapeutics; tumor necrosis factor-alpha
Abstract:
... Hydrogen sulfide (H₂S) exhibits extensive protective actions in cardiovascular systems, such as anti-inflammatory and stimulating angiogenesis, but its therapeutic potential is severely discounted by the short half-life and the poorly controlled releasing behavior. Herein, we developed a macromolecular H₂S prodrug by grafting 2-aminopyridine-5-thiocarboxamide (a small-molecule H₂S donor) on partia ...
DOI:
10.1021/acsami.9b01886

15. Studies on the effects of microencapsulated human mesenchymal stem cells in RGD-modified alginate on cardiomyocytes under oxidative stress conditions using in vitro biomimetic co-culture system

Author:
Goeun Choe; Junggeon Park; Hyerim Jo; Yong Sook Kim; Youngkeun Ahn; Jae Young Lee
Source:
International journal of biological macromolecules 2019 v.123 pp. 512-520
ISSN:
0141-8130
Subject:
alginates; angiogenesis; biomimetics; cardiomyocytes; cell transplantation; coculture; growth factors; humans; hydrogen peroxide; mesenchymal stromal cells; microencapsulation; myocardial infarction; oxidative stress; stem cells
Abstract:
... Stem cell therapy has been recognized as a promising approach for myocardium regeneration post myocardial infarction (MI); however, it unfortunately often remains a challenge because of poor survival of transplanted cells and a lack of clear understanding of their interactions with host cells. High oxidative stress at heart tissues post MI is considered one of the important factors damaging transp ...
DOI:
10.1016/j.ijbiomac.2018.11.115

16. Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing

Author:
Ming Shi; Hao Zhang; Ting Song; Xiaofang Liu; Yunfen Gao; Jianhua Zhou; Yan Li
Source:
ACS applied materials & interfaces 2019 v.11 no.25 pp. 22730-22744
ISSN:
1944-8252
Subject:
alginates; angiogenesis; antibacterial properties; antibiotics; bioactive compounds; biocompatibility; biodegradability; calcium carbonate; cell proliferation; drugs; encapsulation; fibroblast growth factor 2; freeze drying; glass; granulation tissue; hydrogels; microfluidic technology; microparticles; models; pH; rats; rehydration; tissue repair
Abstract:
... Hydrogel-based wound dressings provided a moist microenvironment and local release of bioactive molecules. Single drug loading along with fast release rates and usually in hydrogel sheets limited their performance. Hence, uniform alginate/CaCO₃ composite microparticles (∼430 μm) with tunable compositions for sustainable release of drug and pH-sensitivity were successfully fabricated using microflu ...
DOI:
10.1021/acsami.9b04750

17. The Inhibitory Effect of Propylene Glycol Alginate Sodium Sulfate on Fibroblast Growth Factor 2-Mediated Angiogenesis and Invasion in Murine Melanoma B16-F10 Cells In Vitro

Author:
He Ma; Peiju Qiu; Huixin Xu; Ximing Xu; Meng Xin; Yanyan Chu; Huashi Guan; Chunxia Li; Jinbo Yang
Source:
Marine drugs 2019 v.17 no.5 pp. -
ISSN:
1660-3397
Subject:
alginates; angiogenesis; cell viability; drugs; fibroblast growth factor 2; gelatinase A; gelatinase B; melanoma; metastasis; mice; models; neoplasm cells; patients; propylene glycol; rats; sodium sulfate; vimentin
Abstract:
... Melanoma is one of the most malignant and aggressive types of cancer worldwide. Fibroblast growth factor 2 (FGF2) is one of the critical regulators of melanoma angiogenesis and metastasis; thus, it might be an effective anti-cancer strategy to explore FGF2-targeting drug candidates from existing drugs. In this study, we evaluate the effect of the marine drug propylene glycol alginate sodium sulfat ...
DOI:
10.3390/md17050257
PubMed:
31035725
PubMed Central:
PMC6562581

18. The enrichment of cancer stem cells using composite alginate/polycaprolactone nanofibers

Author:
Wei-Wen Hu; Cheng-Hsien Lin; Zhen-Jie Hong
Source:
Carbohydrate polymers 2019 v.206 pp. 70-79
ISSN:
0144-8617
Subject:
alginates; angiogenesis; antineoplastic agents; cell adhesion; drug resistance; nanofibers; neoplasm cells; neoplasms; stem cells; tissues
Abstract:
... Cancer stem cells (CSCs) are potential platforms to high-throughput screen anti-cancer drugs. However, they are difficult to isolate from cancer cells. Therefore, we proposed to fabricate 3-D scaffolds for CSC enrichment. Alginate is a biocompatible polysaccharide with poor cell adhesion, whereas polycaprolactone (PCL) is relative cell adhesive. These two materials were coelectrospun as composite ...
DOI:
10.1016/j.carbpol.2018.10.087

19. Angiogenesis-promoted bone repair with silicate-shelled hydrogel fiber scaffolds

Author:
Khandmaa Dashnyam; Jennifer O. Buitrago; Tsendmaa Bold; Nandin Mandakhbayar; Roman A. Perez; Jonathan C. Knowles; Jung-Hwan Lee; Hae-Won Kim
Source:
Biomaterials science 2019 v.7 no.12 pp. 5221-5231
ISSN:
2047-4849
Subject:
alginates; angiogenesis; bioactive properties; biocompatible materials; biopolymers; blood vessels; bone formation; calcium; coatings; endothelial cells; endothelial nitric oxide synthase; gene expression; genes; hydrogels; hydroxyapatite; ions; messenger RNA; rats; signal transduction; silicates; skull; therapeutics; vascular endothelial growth factors
Abstract:
... Promoting angiogenesis is a key strategy for stimulating the repair of damaged tissues, including bone. Among other proangiogenic factors, ions have recently been considered a potent element that can be incorporated into biomaterials and then released at therapeutic doses. Silicate-based biomaterials have been reported to induce neovascularization through vascular endothelial growth factor signali ...
DOI:
10.1039/c9bm01103j

20. Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound

Author:
Zefeng Lin; Tingting Wu; Wanshun Wang; Binglin Li; Ming Wang; Lingling Chen; Hong Xia; Tao Zhang
Source:
International journal of biological macromolecules 2019 v.140 pp. 330-342
ISSN:
0141-8130
Subject:
Escherichia coli; alginates; angiogenesis; antibiotic resistance; antibiotics; antimicrobial peptides; antimicrobial properties; biodegradability; collagen; drugs; fibroblasts; hyaluronic acid; mechanical properties; methicillin-resistant Staphylococcus aureus; porosity; silver; tissue repair
Abstract:
... The increase in severe infections caused by antibiotic drug resistance and the decrease in the number of new antibacterial drugs approved for use in the last few decades are driving the need for the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) are a potential new class of antimicrobial drugs that are expected to solve the problem of global antibiotic drug resistance. ...
DOI:
10.1016/j.ijbiomac.2019.08.087

21. CD4 T-cells regulate angiogenesis and myogenesis

Author:
Brian J. Kwee; Erica Budina; Alexander J. Najibi; David J. Mooney
Source:
Biomaterials 2018 v.178 pp. 109-121
ISSN:
0142-9612
Subject:
CD4-positive T-lymphocytes; alginates; angiogenesis; animal models; biobased products; biocompatible materials; cell proliferation; in vitro studies; ischemia; muscle development; myoblasts; phenotype; skeletal muscle
Abstract:
... Ischemic diseases, such as peripheral artery disease, affect millions of people worldwide. While CD4+ T-cells regulate angiogenesis and myogenesis, it is not understood how the phenotype of these adaptive immune cells regulate these regenerative processes. The secreted factors from different types of CD4+ T-cells (Th1, Th2, Th17, and Treg) were utilized in a series of in vitro assays and delivered ...
DOI:
10.1016/j.biomaterials.2018.06.003
PubMed:
29920403
PubMed Central:
PMC6090550

22. Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair

Author:
Eoghan J. Mulholland; Ahlam Ali; Tracy Robson; Nicholas J. Dunne; Helen O. McCarthy
Source:
Journal of controlled release 2019 v.316 pp. 53-65
ISSN:
0168-3659
Subject:
alginates; angiogenesis; blood vessels; cell movement; chitosan; crosslinking; cytotoxicity; mice; nanofibers; nanoparticles; particle size; peptides; polyvinyl alcohol; small interfering RNA; surfactants; therapeutics; tissue repair; transfection; zeta potential
Abstract:
... FK506-binding protein-like (FKBPL) has previously been shown to inhibit angiogenesis viain vitro and in vivo experimentation. Thus, it was proposed that the delivery of a siRNA targeting FKBPL could hold great potential in promoting angiogenesis for advanced wound healing applications. An effective delivery system has been utilised to encapsulate the siFKBPL to form nanoparticles, thereby improvin ...
DOI:
10.1016/j.jconrel.2019.10.050

23. Sustained delivery of anti-VEGF from injectable hydrogel systems provides a prolonged decrease of endothelial cell proliferation and angiogenesis in vitro

Author:
Nathan A. Fletcher; Melissa D. Krebs
Source:
RSC advances 2018 v.8 no.16 pp. 8999-9005
ISSN:
2046-2069
Subject:
adverse effects; alginates; angiogenesis; antibodies; antigens; biodegradability; cell proliferation; chitosan; electrolytes; endothelial cells; hydrogels; immunoglobulin G; macular degeneration; neoplasms; secretion; therapeutics; vascular endothelial growth factors
Abstract:
... Therapeutic antibodies are attractive treatment options for numerous diseases based on their ability to target and bind to specific proteins or antigens. Bevacizumab, an antiangiogenic antibody, has shown promise for multiple diseases, including various cancers and macular degeneration, where excessive VEGF secretion induces aberrant angiogenesis. In many cases local, sustained delivery of a thera ...
DOI:
10.1039/c7ra13014g

24. Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing

Author:
Weilin Yu; Ying-Ying Jiang; Tuan-Wei Sun; Chao Qi; Huakun Zhao; Feng Chen; Zhongmin Shi; Ying-Jie Zhu; Daoyun Chen; Yaohua He
Source:
RSC advances 2016 v.6 no.106 pp. 104375-104387
ISSN:
2046-2069
Subject:
alginates; angiogenesis; blood vessels; drugs; fructose; hot water treatment; human umbilical vein endothelial cells; hydrogels; hydroxyapatite; hypoxia-inducible factor 1; in vivo studies; microparticles; microwave treatment; phosphorus; porous media; signal transduction; tissue repair; vascular endothelial growth factors
Abstract:
... Wound dressings with pro-angiogenic activity are desirable for the rapid healing of full-thickness cutaneous wounds. It is well accepted that simvastatin can stimulate angiogenesis in addition to its lipid-lowering efficacy. However, the construction of a hydrogel-based wound dressing containing simvastatin remains a challenge due to its water-insolubility. In the present study, a novel wound dres ...
DOI:
10.1039/c6ra20892d

25. Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)

Author:
Franciely S. Oliveira; Andreia Ribeiro; Lillian Barros; Ricardo C. Calhelha; João C.M. Barreira; Bogdan D. Junior; Rui M.V. Abreu; Maria Filomena Barreiro; Isabel C.F.R. Ferreira
Source:
Journal of functional foods 2017 v.38 pp. 214-220
ISSN:
1756-4646
Subject:
Arenaria montana; alginates; angiogenesis; apigenin; case studies; chemoprevention; fatty acid composition; functional foods; ingredients; microencapsulation; nutritive value; phosphorylation; sugars; vascular endothelial growth factor receptor-2; yogurt
Abstract:
... Natural ingredients are valuable options to be exploited in the design of innovative food formulations with health benefits. Therefore, it was evaluated the potential use of Arenaria montana L. hydroethanolic extract (rich in apigenin derivatives) as a chemopreventive agent in functional foods. Apigenin is recognized as inhibiting VEGFR-2, which is the key receptor involved in angiogenesis. The ob ...
DOI:
10.1016/j.jff.2017.09.027

26. Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis

Author:
Anthony J. Monteforte; Brian Lam; Subhamoy Das; Somshuvra Mukhopadhyay; Catherine S. Wright; Patricia E. Martin; Andrew K. Dunn; Aaron B. Baker
Source:
Biomaterials 2016 v.94 pp. 45-56
ISSN:
0142-9612
Subject:
alginates; angiogenesis; animal disease models; blood vessels; cell proliferation; endothelial cells; growth factors; hindlimbs; ischemia; mice; noninsulin-dependent diabetes mellitus; obesity; patients; therapeutics; tissues
Abstract:
... Therapeutic angiogenesis is a highly appealing concept for treating tissues that become ischemic due to vascular disease. A major barrier to the clinical translation of angiogenic therapies is that the patients that are in the greatest need of these treatments often have long term disease states and co-morbidities, such as diabetes and obesity, that make them resistant to angiogenic stimuli. In th ...
DOI:
10.1016/j.biomaterials.2016.03.048
PubMed:
27101205
PubMed Central:
PMC5600893

27. Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis

Author:
A.L. Torres; S.J. Bidarra; M.T. Pinto; P.C. Aguiar; E.A. Silva; C.C. Barrias
Source:
Biomaterials 2017 pp. -
ISSN:
0142-9612
Subject:
alginates; angiogenesis; biomechanics; chickens; chicks; collagen; endothelial cells; extracellular matrix; fibronectins; humans; morphogenesis; normoxia; peptides; stem cells
Abstract:
... Efficient cell delivery strategies are urgently needed to improve the outcome of cell-based pro-angiogenic therapies. This study describes the design of an injectable cell delivery platform, based on biomaterial-guided morphogenesis principles. Soft high-mannuronic acid alginate microgels, oxidized and functionalized with integrin-binding peptides, provided adequate biochemical/biomechanical cues ...
DOI:
10.1016/j.biomaterials.2017.10.051

28. The study of angiogenesis stimulated by multivalent peptide ligand-modified alginate

Author:
Bicui Wang; Wei Wang; Yanyan Yu; Yingxue Zhang; Jingwei Zhang; Zhi Yuan
Source:
Colloids and surfaces 2017 v.154 pp. 383-390
ISSN:
0927-7765
Subject:
adhesion; alginates; angiogenesis; binding capacity; blood vessels; colloids; human umbilical vein endothelial cells; ligands; nanogold; tissue engineering
Abstract:
... Enhancing the affinity of scaffolds for endothelial cell (EC) is a crucial procedure for promoting angiogenesis in tissue engineering. In this work, to achieve stronger binding affinity with ECs, the peptide sequence REDV was conjugated onto gold nanoparticles (AuNPs) to construct a multivalent ligand (cREDV). Then, the EC adhesion and proliferation were studied to determine ligand affinity for EC ...
DOI:
10.1016/j.colsurfb.2017.03.049

29. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging

Author:
Kislay Roy; Rupinder K. Kanwar; Jagat R. Kanwar
Source:
Biomaterials 2015 v.71 pp. 84-99
ISSN:
0142-9612
Subject:
alginates; angiogenesis; antineoplastic agents; apoptosis; calcium; calcium phosphates; caspases; chemoattractants; chitosan; colorectal neoplasms; dendritic cells; epithelial cell adhesion molecule; erythrocytes; gene expression; hemoglobin; image analysis; interleukins; iron; iron oxides; keratinocytes; lactoferrin; macrophages; magnetic resonance imaging; mice; mitochondria; mitogen-activated protein kinase; monocytes; nanocapsules; nanocarriers; nanoparticles; nucleic acids; oligonucleotides; phosphorylation; pro-apoptotic proteins; stem cells; survival rate; tissue analysis; tomography; zinc
Abstract:
... This is the first ever attempt to combine anti-cancer therapeutic effects of emerging anticancer biodrug bovine lactoferrin (bLf), and multimodal imaging efficacy of Fe3O4 nanoparticles (NPs) together, as a saturated Fe3O4-bLf. For cancer stem cell specific uptake of nanocapsules/nanocarriers (NCs), Fe3O4-bLf was encapsulated in alginate enclosed chitosan coated calcium phosphate (AEC-CP) NCs targ ...
DOI:
10.1016/j.biomaterials.2015.07.055

30. Design of a thermosensitive bioglass/agarose–alginate composite hydrogel for chronic wound healing

Author:
Qiongyu Zeng; Yan Han; Haiyan Li; Jiang Chang
Source:
Journal of materials chemistry B 2015 v.3 no.45 pp. 8856-8864
ISSN:
2050-7518
Subject:
agarose; alginates; angiogenesis; blood vessels; coculture; crosslinking; ears; endothelial cells; epithelium; fibroblasts; humidity; hydrogels; ions; models; polymers; rabbits; temperature; thermosensitivity; tissue repair
Abstract:
... Chronic wounds are a major health problem around the world, and there is a need to develop new types of dressing materials to enhance chronic wound healing. Humidity and angiogenic conditions are two important factors that may significantly affect the healing process. Therefore, a new wound dressing system based on bioglass (BG) and agarose–alginate (AA) has been designed, which can create a moist ...
DOI:
10.1039/c5tb01758k

31. Injectable multifunctional microgel encapsulating outgrowth endothelial cells and growth factors for enhanced neovascularization

Author:
Pyung-Hwan Kim; Hyun-Gu Yim; Young-Jin Choi; Byung-Jae Kang; Joohyun Kim; Sang-Mo Kwon; Byung-Soo Kim; Nathaniel S. Hwang; Je-Yoel Cho
Source:
Journal of controlled release 2014 v.187 pp. 1-13
ISSN:
0168-3659
Subject:
alginates; angiogenesis; angiogenic proteins; aorta; blood flow; cell viability; electrospraying; encapsulation; endothelial cells; hepatocyte growth factor; histology; hydrogels; ischemia; mice; models; nanotechnology; rats; stem cells; therapeutics; toxicity; vascular diseases; vascular endothelial growth factors
Abstract:
... Recent cell-based therapy approaches have employed both nanotechnologies and other biomedical technologies to enhance their therapeutic potential. A combined strategy using therapeutic stem/progenitor cells and angiogenic proteins is attractive for the treatment of vascular disease. In this study, we developed an injectable multifunctional micro-sized gel system (microgel), composed of arginine–gl ...
DOI:
10.1016/j.jconrel.2014.05.010

32. Fibroblast-derived matrix (FDM) as a novel vascular endothelial growth factor delivery platform

Author:
Ping Du; Mintai P. Hwang; Yong Kwan Noh; Ramesh Subbiah; In Gul Kim; Soon Eon Bae; Kwideok Park
Source:
Journal of controlled release 2014 v.194 pp. 122-129
ISSN:
0168-3659
Subject:
alginates; angiogenesis; blood vessels; cell proliferation; dose response; extracellular matrix; heparin; human umbilical vein endothelial cells; mice; vascular endothelial growth factors
Abstract:
... Vascular endothelial growth factor (VEGF) is one of the most important signaling cues during angiogenesis. Since many delivery systems of VEGF have been reported, the presentation of VEGF using a more physiologically relevant extracellular matrix (ECM), however, has yet to be thoroughly examined. In this study, we propose that fibroblast-derived extracellular matrix (FDM) is a novel platform for a ...
DOI:
10.1016/j.jconrel.2014.08.026

33. Overcoming disease-induced growth factor resistance in therapeutic angiogenesis using recombinant co-receptors delivered by a liposomal system

Author:
Subhamoy Das; Gunjan Singh; Aaron B. Baker
Source:
Biomaterials 2014 v.35 no.1 pp. 196-205
ISSN:
0142-9612
Subject:
alginates; angiogenesis; animal models; blood flow; blood vessels; diabetes; high fat diet; ischemia; mice; obesity; patients; platelet-derived growth factor receptor alpha; protein content; receptors; signal transduction; skeletal muscle; therapeutics; vascular endothelial growth factor A
Abstract:
... Current treatment options for ischemia include percutaneous interventions, surgical bypass or pharmacological interventions aimed at slowing the progression of vascular disease. Unfortunately, while each of these treatment modalities provides some benefit for patients in the short-term, many patients have resistant or recurrent disease that is poorly managed by these therapies. A highly appealing ...
DOI:
10.1016/j.biomaterials.2013.09.105
PubMed:
24138828
PubMed Central:
PMC3909708