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- Okuno, M., et al. Show all 7 Authors
- Nutrition and cancer 1998 v.32 no.1 pp. 20-24
- alpha-carotene; beta-carotene; canthaxanthin; colon; neoplasms; retinoic acid; viability; DNA; biosynthesis; cell division; receptors; genes; messenger RNA; gene expression; cell lines; humans
- ... The present study employed two human colon cancer cell lines, DLD-1 and Colo 320DM, to investigate whether the provitamin A activity of carotenoids is necessary for their antitumor effect on colon cancer. Carotenoids, including alpha- and beta-carotene and canthaxanthin, significantly suppressed cell viability [measured by tetrazolium (MTT) assay], DNA synthesis (measured by (3H]thymidine uptake), ...