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- Lee, Seongsoo, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2016
- Drosophila; amyotrophic lateral sclerosis; brain; mitochondria; models; motor neurons; muscles; mutants; pathogenesis; proteins; regulator genes; spinal cord
- ... Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease, characterized by progressive and selective loss of motor neurons in the brain and spinal cord. DNA/RNA-binding proteins such as TDP-43, FUS, and TAF15 have been linked with the sporadic and familial forms of ALS. However, the exact pathogenic mechanism of ALS is still unknown. Recently, we found that ALS-causing gene ...
- Lee, Seongsoo, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2019 v.513 no.4 pp. 925-932
- Alzheimer disease; Parkinson disease; amyotrophic lateral sclerosis; autophagy; death; enzymes; neurons; protein aggregates; therapeutics; toxicity
- ... The most prominent hallmarks of many neurodegenerative diseases are the accumulation of misfolded protein aggregates and the death of certain neuronal populations. Autophagy is the major intracellular mechanism that degrades protein aggregates and damaged cellular components. Many studies have reported that the dysfunction of autophagy is associated with several neurodegenerative diseases, such as ...