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You searched for: Author "Lee, Seongsoo" Remove constraint Author: "Lee, Seongsoo" Subject amyotrophic lateral sclerosis Remove constraint Subject: amyotrophic lateral sclerosis
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1. Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis

Author:
Lee, Seongsoo,   et al.   ; Altanbyek, Volodya; Cha, Sun-Joo; Kang, Ga-Un; Im, Dai Sic; Kim, Hyung-Jun; Kim, Kiyoung;     Show all 7 Authors
Source:
Biochemical and biophysical research communications 2016
ISSN:
0006-291X
Subject:
Drosophila; amyotrophic lateral sclerosis; brain; mitochondria; models; motor neurons; muscles; mutants; pathogenesis; proteins; regulator genes; spinal cord
Abstract:
... Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease, characterized by progressive and selective loss of motor neurons in the brain and spinal cord. DNA/RNA-binding proteins such as TDP-43, FUS, and TAF15 have been linked with the sporadic and familial forms of ALS. However, the exact pathogenic mechanism of ALS is still unknown. Recently, we found that ALS-causing gene ...
DOI:
10.1016/j.bbrc.2016.10.134

2. Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway

Author:
Lee, Seongsoo,   et al.   ; Jo, Myungjin; Lee, Shinrye; Kim, Kiyoung; Kim, Sang Ryong; Kim, Hyung-Jun;     Show all 6 Authors
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 925-932
ISSN:
0006-291X
Subject:
Alzheimer disease; Parkinson disease; amyotrophic lateral sclerosis; autophagy; death; enzymes; neurons; protein aggregates; therapeutics; toxicity
Abstract:
... The most prominent hallmarks of many neurodegenerative diseases are the accumulation of misfolded protein aggregates and the death of certain neuronal populations. Autophagy is the major intracellular mechanism that degrades protein aggregates and damaged cellular components. Many studies have reported that the dysfunction of autophagy is associated with several neurodegenerative diseases, such as ...
DOI:
10.1016/j.bbrc.2019.04.088