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You searched for: Subject term angiogenesis Remove constraint Subject term: angiogenesis Subject term Escherichia coli Remove constraint Subject term: Escherichia coli
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1. Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing

Author:
Shengbo Li; Xuemei Wang; Jing Chen; Jiahe Guo; Meng Yuan; Gui Wan; Chengqi Yan; Wenqing Li; Hans-Günther Machens; Yuval Rinkevich; Xiaofan Yang; Heng Song; Zhenbing Chen
Source:
International journal of biological macromolecules 2022 v.202 pp. 657-670
ISSN:
0141-8130
Subject:
Escherichia coli; angiogenesis; calcium; copper nanoparticles; crosslinking; deferoxamine; dose response; health services; humans; hydrogels; inflammation; mice; sodium alginate; toxicity testing; vascular endothelial growth factors
Abstract:
... Chronic non-healing diabetic wounds and ulcers can be fatal, lead to amputations, and remain a major challenge to medical, and health care sectors. Susceptibility to infection and impaired angiogenesis are two central reasons for the clinical consequences associated with chronic non-healing diabetic wounds. Herein, we successfully developed calcium ion (Ca²⁺) cross-linked sodium alginate (SA) hydr ...
DOI:
10.1016/j.ijbiomac.2022.01.080

2. Characterization and fabrication of zinc oxide nanoparticles by gum Acacia modesta through green chemistry and impregnation on surgical sutures to boost up the wound healing process

Author:
Muhammad Irfan; Hira Munir; Hammad Ismail
Source:
International journal of biological macromolecules 2022 v.204 pp. 466-475
ISSN:
0141-8130
Subject:
Acacia modesta; Escherichia coli; angiogenesis; antibacterial properties; collagen; color; energy-dispersive X-ray analysis; fibroblasts; green chemistry; gum arabic; histopathology; inflammation; methicillin-resistant Staphylococcus aureus; models; oxygen; stoichiometry; surgery; tensile strength; zinc; zinc oxide
Abstract:
... In the present research, we developed zinc oxide nanoparticles (ZnO-NPs) based surgical sutures for the accelerated wound healing process. Color change from transparent to dark, surface plasmon response with a peak at 270 nm and infra-red spectra with ZnO-bond stretches at 489.6831 cm⁻¹ confirmed the synthesis of NPs. Rod shape ZnO-NPs with an ideal size of 70 ± 03 nm were noted with uniform distr ...
DOI:
10.1016/j.ijbiomac.2022.02.043

3. Molecular Mechanisms of Lipopolysaccharide (LPS) Induced Inflammation in an Immortalized Ovine Luteal Endothelial Cell Line (OLENDO)

Author:
Aykut Gram; Mariusz P. Kowalewski
Source:
Veterinary sciences 2022 v.9 no.3 pp. -
ISSN:
2306-7381
Subject:
Escherichia coli; Gram-negative bacteria; angiogenesis; cell lines; endothelial cells; inflammation; interleukin-6; interleukin-8; lipopolysaccharides; mammary glands; mitogen-activated protein kinase; morphogenesis; phosphorylation; sheep; transcription factor NF-kappa B; uterus
Abstract:
... Escherichia coli (E. coli) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, fertility problems occur in part due to disrupted follicular and luteal functionality. However, the molecular mechanisms by which LPS induces inflammati ...
DOI:
10.3390/vetsci9030099

4. Multi-functional Calotropis gigantea fabric using self-assembly silk fibroin, chitosan and nano-silver microspheres with oxygen low-temperature plasma treatment

Author:
Zeyu Zhao; Jia Yan; Tao Wang; Yanxue Ma; Maobin Xie; Xuan Mu; Xiaoqin Wang; Zhaozhu Zheng; Yuling Li; Gang Li
Source:
Colloids and surfaces 2022 v.215 pp. 112488
ISSN:
0927-7765
Subject:
Calotropis gigantea; Escherichia coli; Staphylococcus aureus; adhesion; angiogenesis; antibacterial properties; biocompatibility; chitosan; fabrics; fibroins; microparticles; nanosilver; oxygen
Abstract:
... The present paper describes a novel multi-functional Calotropis gigantea (CG) fabric with durable antibacterial property and comfortable wearability for various applications. First, antibacterial microspheres (AMs) were prepared by self-assembly of silk fibroin (SF), chitosan (CS) and nano-silver microspheres (NSMs). Oxygen low-temperature plasma (OLTP) treatment was used to improve the adhesion b ...
DOI:
10.1016/j.colsurfb.2022.112488

5. The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing

Author:
Hussein E. Rozan; Guangsheng Wu; Zhongzheng Zhou; Qinfeng Li; Mohamed Sharaf; Xiguang Chen
Source:
Colloids and surfaces 2022 v.216 pp. 112523
ISSN:
0927-7765
Subject:
Bacillariophyceae; Escherichia coli; angiogenesis; biocompatibility; chitosan; collagen; cytotoxicity; doxycycline; hydrogels
Abstract:
... In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing. The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%). In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of t ...
DOI:
10.1016/j.colsurfb.2022.112523

6. Wound healing activity of the hydroalcoholic extract and the main metabolites of Amphipterygium adstringens (cuachalalate) in a rat excision model

Author:
Christian Verónica Pérez-Contreras; Jesús Alvarado-Flores; Alejandra Orona-Ortiz; José Luis Balderas-López; Rosa María Salgado; Noé Zacaula-Juárez; Edgar Krötzsch; Andrés Navarrete
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115313
ISSN:
0378-8741
Subject:
Anacardiaceae; Escherichia coli; angiogenesis; antimicrobial properties; aspirin; bark; chick embryos; chorioallantoic membrane; excision; histamine; histology; metabolites; mice; minimum inhibitory concentration; models; rats; traditional medicine; Mexico
Abstract:
... The bark of Amphipterygium adstringens Schiede ex Schltdl (Anacardiaceae), commonly known as ‘cuachalalate’ has been used in Mexican traditional medicine for the treatment of skin and oral lesions, gastric ulcers, and other conditions. The use as wound healing of the bark of this plant has been known since before the Spanish conquest of Mexico. Its uses are mentioned in the first writings of the S ...
DOI:
10.1016/j.jep.2022.115313

7. Antibacterial, proangiogenic, and osteopromotive nanoglass paste coordinates regenerative process following bacterial infection in hard tissue

Author:
Jung Ju Seo; Nandin Mandakhbayar; Min Sil Kang; Ji-Young Yoon; Na-Hyun Lee; Junyong Ahn; Hae-Hyoung Lee; Jung-Hwan Lee; Hae-Won Kim
Source:
Biomaterials 2021 v.268 pp. 120593
ISSN:
0142-9612
Subject:
Escherichia coli; angiogenesis; antibacterial properties; bacterial infections; biocompatible materials; bone formation; calcium; copper; homeostasis; inflammation; osteomyelitis; silicates; surface area; tibia; tissue repair
Abstract:
... Bacterial infection raises serious concerns in tissue repair settings involved with implantable biomaterials, devastating the regenerative process and even life-threatening. When hard tissues are infected with bacteria (called ‘osteomyelitis’), often the cases in open fracture or chronic inflammation, a complete restoration of regenerative capacity is significantly challenging even with highly-dos ...
DOI:
10.1016/j.biomaterials.2020.120593

8. Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3

Author:
Jian Yuan; Xiaolong Jiang; Huijing Zhang; Jing Bai; Jing Zhang; Yuhui Wang; Gege Lu; Huimin Xu; Huanhuan Liu; Bin Liu; Di Huang
Source:
Green chemistry 2021 v.23 no.7 pp. 2668-2684
ISSN:
1463-9270
Subject:
Escherichia coli; Helicobacter pylori; N-acetylglucosamine; Neisseria meningitidis; Streptococcus parasanguinis; absorption; angiogenesis; biochemical pathways; biomarkers; biosynthesis; carbon; cytoplasm; epitopes; galectins; glucose; glycerol; glycolipids; glycoproteins; glycosylation; glycosyltransferases; green chemistry; metastasis; neoplasms; polymerization
Abstract:
... Galectin-3 (Gal-3), a member of the β-galactoside-binding lectin family, involved in tumor angiogenesis and metastasis, is considered a diagnostic biomarker and a promising treatment target for early cancer. Gal-3 recognizes the poly-N-acetyllactosamine (poly-LacNAc)-based carbohydrate motifs of glycoproteins and glycolipids. To date, protein glycosylation with poly-LacNAc has been mainly achieved ...
DOI:
10.1039/d0gc04331a

9. Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Author:
Haiyan Cui; Mingsheng Liu; Wenwen Yu; Yufei Cao; Haicun Zhou; Juanjuan Yin; Hongbin Liu; Sheng Que; Jingjing Wang; Congshu Huang; Chenliang Gong; Guanghui Zhao
Source:
ACS applied materials & interfaces 2021 v.13 no.23 pp. 26800-26807
ISSN:
1944-8252
Subject:
Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; angiogenesis; antibacterial properties; collagen; copper hydroxide; gelatin; hydrogen peroxide; toxicity
Abstract:
... Catalytic conversion of hydrogen peroxide (H₂O₂) to more toxic hydroxyl radicals (•OH) is a good choice for sterilization and anti-infection, but endogenous H₂O₂ is insufficient to achieve satisfactory sterilization efficacy. Despite great efforts, designing and developing antimicrobial materials that specifically and effectively self-supply H₂O₂ at the wound site remain as tremendous challenges. ...
DOI:
10.1021/acsami.1c07409

10. Production and optimization of a vasostatin-30 and vasoinhibin fusion protein that inhibits tumor angiogenesis and dissemination of breast cancer cells in a zebrafish model

Author:
Gabriela Vazquez-Rodriguez; Edgar R. Juvera Avalos; Carmen Gonzalez; Ana P. Barba de la Rosa; Antonio De Leon-Rodriguez
Source:
Process biochemistry 2022 v.119 pp. 1-12
ISSN:
1359-5113
Subject:
Danio rerio; Escherichia coli; angiogenesis; bioactive properties; breast neoplasms; cancer therapy; cell proliferation; experimental design; metastasis; models; pH; recombinant fusion proteins
Abstract:
... Angiogenesis plays a key role in tumor growth and metastasis. Current antiangiogenic drugs have shown poor clinical benefit making the development of new antiangiogenic agents a clinical need. In this work, we optimized the production of a recombinant fusion protein derived from vasostatin-30 (VS30) and vasoinhibin (Vi), named VS_VI, using Escherichia coli and the central composite experimental de ...
DOI:
10.1016/j.procbio.2022.05.002

11. Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Author:
Chenxi Tu; Huidan Lu; Tong Zhou; Wanying Zhang; Liwen Deng; Wangbei Cao; Zhijian Yang; Zhaolong Wang; Xinyu Wu; Jie Ding; Feng Xu; Changyou Gao
Source:
Biomaterials 2022 pp. 121597
ISSN:
0142-9612
Subject:
Escherichia coli; Pseudomonas aeruginosa; angiogenesis; biocompatible materials; biofilm; collagen; crosslinking; epithelium; hydrogels; hydrophilicity; hypoxia; interleukin-10; interleukin-4; interleukin-6; macrophages; manganese dioxide; metabolism; methicillin-resistant Staphylococcus aureus; nanosheets; necrosis; neoplasms; neutrophils; oxidative stress; oxygen; pravastatin; reactive oxygen species; secretion; transcriptomics; virulence
Abstract:
... The diabetic wound is easily to develop into a chronic wound because of the extremely serious and complex inflammatory microenvironment including biofilm formation, over-expressed reactive oxygen species (ROS), hypoxia and insufficiency of nitric oxide (NO) synthesis. In this work, a multifunctional hydrogel was designed and prepared by crosslinking hydrophilic poly (PEGMA-co-GMA-co-AAm) (PPGA) po ...
DOI:
10.1016/j.biomaterials.2022.121597

12. Tea polyphenol/glycerol-treated double-network hydrogel with enhanced mechanical stability and anti-drying, antioxidant and antibacterial properties for accelerating wound healing

Author:
Lanlan Dong; Zhengzhe Han; Hang Zhang; Renhao Yang; Jinhui Fang; Lei Wang; Xiaolin Li; Xiang Li
Source:
International journal of biological macromolecules 2022 v.208 pp. 530-543
ISSN:
0141-8130
Subject:
Escherichia coli; angiogenesis; antibacterial properties; antioxidants; collagen; crosslinking; gelatin; glycerol; hydrogels; hydrogen; hygroscopicity; laponite; oxidative stress; polyphenols; solvents; tea; tensile strength
Abstract:
... Frequent dressing changes can result in secondary wound damage. Therefore, it is of great significance to construct a wound dressing that can be used for a long time without changing. Here, a double-network hydrogel was synthesized through hydrogen bonding interactions of tea polyphenol (TP)/glycerol with photo-crosslinked N-acryloyl glycinamide (NAGA), gelatin methacrylate (GelMA), and nanoclay h ...
DOI:
10.1016/j.ijbiomac.2022.03.128

13. Construction of wound repair model and function of recombinant TIMP from Hyriopsis cumingii

Author:
Jinhua An; Chengli Wang; Shaoqing Jian; Yang Gang; Chungen Wen; Baoqing Hu
Source:
Fish & shellfish immunology 2021 v.119 pp. 533-541
ISSN:
1050-4648
Subject:
Escherichia coli; Hyriopsis cumingii; amino acid sequences; amino acids; angiogenesis; cell growth; extracellular matrix; fish; hemocytes; hepatopancreas; humans; immune response; metabolism; metalloproteinases; models; molecular weight; plasmids; shellfish
Abstract:
... Metalloproteinase tissue inhibitors (TIMPs) have the activity of inhibiting matrix metalloproteinases (MMPs), which can promote cell growth, bind to the matrix, inhibit angiogenesis, and play a key role in extracellular matrix (ECM) metabolism regulation. In this study, TIMP-1, 2 from Hyriopsis cumingii (designated as HcTIMP-1, 2) were cloned and identified. Full-length cDNA of HcTIMP-1, 2 was 116 ...
DOI:
10.1016/j.fsi.2021.10.036

14. Controlling morphology evolution of titanium oxide–gold nanourchin for photocatalytic degradation of dyes and photoinactivation of bacteria in the infected wound

Author:
Binesh Unnikrishnan; Irma Suryani Gultom; Yu-Ting Tseng; Huan-Tsung Chang; Chih-Ching Huang
Source:
Journal of colloid and interface science 2021 v.598 pp. 260-273
ISSN:
0021-9797
Subject:
Candida albicans; Escherichia coli; absorption; ambient temperature; angiogenesis; catechin; collagen; dyes; gold; keratinocytes; light intensity; methicillin-resistant Staphylococcus aureus; nanocomposites; photocatalysis; reactive oxygen species; titanium; titanium dioxide; xenon
Abstract:
... We report a one-pot, room-temperature, morphology-controlled synthesis of titanium oxide (TiOₓ)–gold nanocomposites (TiOₓ–Au NCs) using HAuCl₄ and TiCl₃ as precursors, and catechin as reducing agent. TiOₓ–Au NCs have a range of morphologies from star-like to urchin-like shape depending on the concentration of TiCl₃ in the reaction mixture. The urchin-shaped TiOₓ–Au NCs exhibited excellent photocat ...
DOI:
10.1016/j.jcis.2021.04.035

15. Exploration of the antibacterial and wound healing potential of a PLGA/silk fibroin based electrospun membrane loaded with zinc oxide nanoparticles

Author:
Atta ur Rehman Khan; Kai Huang; Zhao Jinzhong; Tonghe Zhu; Yosry Morsi; Ali Aldalbahi; Mohamed El-Newehy; Xiaoyu Yan; Xiumei Mo
Source:
Journal of materials chemistry B 2021 v.9 no.5 pp. 1452-1465
ISSN:
2050-7518
Subject:
Escherichia coli; X-ray diffraction; angiogenesis; antibacterial properties; antioxidant activity; antioxidants; bioavailability; biocompatibility; biological assessment; cell culture; cell movement; collagen; encapsulation; fibroins; granulation tissue; nanofibers; polymers; tensile strength; transmission electron microscopy; zinc oxide
Abstract:
... Zinc oxide nanoparticles (ZnO NPs) are known for their antibacterial, antioxidant, and anti-inflammatory activities. Moreover, ZnO NPs can stimulate cell migration, re-epithelialization, and angiogenesis. All these attributes are highly relevant to wound healing. Local administration of ZnO NPs to the wound can be achieved through electrospun nanofibers. We hypothesized that the use of poly(lactid ...
DOI:
10.1039/d0tb02822c

16. Exploring the Role of Gut Microbiome in Colon Cancer

Author:
Indranil Chattopadhyay; Ruby Dhar; Karthikeyan Pethusamy; Ashikh Seethy; Tryambak Srivastava; Ramkishor Sah; Jyoti Sharma; Subhradip Karmakar
Source:
Applied biochemistry and biotechnology 2021 v.193 no.6 pp. 1780-1799
ISSN:
0273-2289
Subject:
Bacteroides fragilis; Bifidobacterium; Clostridium; Escherichia coli; Lactobacillus; Roseburia; Streptococcus gallolyticus; angiogenesis; biotechnology; colon; colorectal neoplasms; dysbiosis; epithelium; fermentation; immunology; inflammation; intestinal microorganisms; lifestyle; metabolites; metabolomics; metagenomics; probiotics; secretion; transcriptomics
Abstract:
... Dysbiosis of the gut microbiome has been associated with the development of colorectal cancer (CRC). Gut microbiota is involved in the metabolic transformations of dietary components into oncometabolites and tumor-suppressive metabolites that in turn affect CRC development. In a healthy colon, the major of microbial metabolism is saccharolytic fermentation pathways. The alpha-bug hypothesis sugges ...
DOI:
10.1007/s12010-021-03498-9

17. Fabrication of Dexamethasone-Loaded Dual-Metal–Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Author:
Tianhua Xiao; Lei Fan; Rongtao Liu; Xingwen Huang; Shihuan Wang; Liangang Xiao; Yiyu Pang; Da Li; Jia Liu; Yonggang Min
Source:
ACS applied materials & interfaces 2021 v.13 no.43 pp. 50836-50850
ISSN:
1944-8252
Subject:
Escherichia coli; Staphylococcus aureus; angiogenesis; antibacterial properties; bone formation; bone marrow; bone transplantation; chickens; chorioallantoic membrane; dexamethasone; human umbilical vein endothelial cells; hydrophilicity; mesenchymal stromal cells; models; polymers; rats
Abstract:
... Polyetheretherketone (PEEK) is a biocompatible polymer, but its clinical application is largely limited due to its inert surface. To solve this problem, a multifunctional PEEK implant is urgently fabricated. In this work, a dual-metal–organic framework (Zn–Mg-MOF74) coating is bonded to PEEK using a mussel-inspired polydopamine interlayer to prepare the coating, and then, dexamethasone (DEX) is lo ...
DOI:
10.1021/acsami.1c18088

18. Microenvironment-responsive multifunctional hydrogels with spatiotemporal sequential release of tailored recombinant human collagen type III for the rapid repair of infected chronic diabetic wounds [Erratum: January 2022, v.10(2), p.328]

Author:
Cheng Hu; Wenqi Liu; Linyu Long; Zhicun Wang; Yihui Yuan; Wen Zhang; ShuYi He; Jian Wang; Li Yang; Lu Lu; Yunbing Wang
Source:
Journal of materials chemistry B 2021 v.9 no.47 pp. 9684-9699
ISSN:
2050-7518
Subject:
Escherichia coli; angiogenesis; antioxidants; cell proliferation; collagen; fibroblast growth factor 2; fibroblasts; humans; hydrogels; inflammation; mice; therapeutics; vascular endothelial growth factors
Abstract:
... Recently, the incidence of chronic diabetic wounds increases continuously, and the existing clinical treatment is less effective. Thus, it is an urgent need to solve these problems for better clinical treatment effects. Herein, we prepared a brand-new tailored recombinant human collagen type III (rhCol III) and constructed a multifunctional microenvironment-responsive hydrogel carrier based on mul ...
DOI:
10.1039/d1tb02170b

19. Novel multifunctional adenine-modified chitosan dressings for promoting wound healing

Author:
Pengpeng Deng; Wenyi Jin; Zilin Liu; Mingyong Gao; Jinping Zhou
Source:
Carbohydrate polymers 2021 v.260 pp. 117767
ISSN:
0144-8617
Subject:
DNA; Escherichia coli; angiogenesis; biocompatibility; biocompatible materials; chitosan; collagen; epithelium; freeze drying; immunohistochemistry; interphase; models; water solubility
Abstract:
... Wound healing is a dynamic and intricate process, and newly dressings are urgently needed to promote wound healing over the multiple stages. Herein, two water-soluble adenine-modified chitosan (CS-A) derivatives were synthesized in aqueous solutions and freeze-dried to obtain porous sponge-like dressings. The novel derivatives displayed antibacterial activities against S. aureus and E. coli. Moreo ...
DOI:
10.1016/j.carbpol.2021.117767

20. PDA/Cu Bioactive Hydrogel with “Hot Ions Effect” for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing

Author:
Qing Xu; Mengling Chang; Yu Zhang; Endian Wang; Min Xing; Long Gao; Zhiguang Huan; Feng Guo; Jiang Chang
Source:
ACS applied materials & interfaces 2020 v.12 no.28 pp. 31255-31269
ISSN:
1944-8252
Subject:
Escherichia coli; angiogenesis; antibacterial properties; antibiotic resistance; bacteria; calcium silicate; ceramics; collagen; copper; heat; hydrogels; ions; methicillin; methicillin-resistant Staphylococcus aureus; therapeutics; tissue repair
Abstract:
... Quick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the phototh ...
DOI:
10.1021/acsami.0c08890