Subject term: animal disease models and glycemic effect / Text availability: Citation in PubAg

1. Antihyperglycemic Activity of Helicteres isora Roots in Alloxan-Induced Diabetic Rats

Author:: Venkatesh, Sama; Reddy, G. Dayanand; Reddy, B. Madhava
Source:: Pharmaceutical biology 2003 v.41 no.5 pp. 347-350
ISSN:: 1388-0209
Subject:: Helicteres; animal disease models; blood glucose; butanol; chloroform; diabetes mellitus; ethanol; ethyl acetate; glycemic effect; rats; roots
Abstract:: ... The effect of administrating different extracts of Helicteres isora L. (Sterculiaceae) roots on blood glucose levels in normal and alloxan-induced diabetic rats was evaluated in this study. Among the five fractions (aqueous ethanol, chloroform, ethyl acetate, butanol and left over aqueous), the butanol fraction at a dose of 250 mg/kg showed maximum antihyperglycemic activity. The same dose did not ...
DOI:: 10.1076/phbi.41.5.347.15937
: https://doi.org/10.1076/phbi.41.5.347.15937

2. Antioxidant activity of Indian herbal drugs in rats with alloxan-induced diabetes

Author:: Sabu, M.C.; Kuttan, R.
Source:: Pharmaceutical biology 2003 v.41 no.7 pp. 500-505
ISSN:: 1388-0209
Subject:: herbal medicines; plant extracts; antioxidant activity; glycemic effect; blood glucose; diabetes; rats; animal disease models; India
DOI:: 10.1080/13880200308951343
: https://doi.org/10.1080/13880200308951343

3. Amelioration of altered antioxidant status and membrane linked functions by vanadium andTrigonella in alloxan diabetic rat brains

Author:: Mohammad Rizwan Siddiqui; Asia Taha; K. Moorthy; Mohd. Ejaz Hussain; S. F. Basir; Najma Zaheer Baquer
Source:: Journal of biosciences 2005 v.30 no.4 pp. 483-490
ISSN:: 0250-5991
Subject:: Trigonella foenum-graecum; adenosinetriphosphatase; alloxan; animal disease models; antioxidant activity; antioxidants; blood glucose; brain; catalase; diabetes mellitus; glutathione peroxidase; glycemic effect; insulin; lipid peroxidation; membrane fluidity; rats; sodium; sodium-potassium-exchanging ATPase; superoxide dismutase; toxicity; vanadium
Abstract:: ... Trigonella foenum graecum seed powder (TSP) and sodium orthovanadate (SOV) have been reported to have antidiabetic effects. However, SOV exerts hypoglycemic effects at relatively high doses with several toxic effects. We used low doses of vanadate in combination with TSP and evaluated their antidiabetic effects on antioxidant enzymes and membrane-linked functions in diabetic rat brains. In rats, d ...
DOI:: 10.1007/BF02703722
: https://doi.org/10.1007/BF02703722

4. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats

Author:: Ramesh, B.; Saravanan, R.; Pugalendi, K.V.
Source:: Journal of medicinal food 2005 v.8 no.3 pp. 377-381
ISSN:: 1096-620X
Subject:: spice oils; lipid peroxidation; diabetes mellitus; medicinal plants; dietary supplements; medicinal properties; females; animal disease models; traditional medicine; sesame oil; blood glucose; glycemic effect; kidneys; rats; antioxidant activity; antioxidants; liver; streptozotocin; India
DOI:: 10.1089/jmf.2005.8.377
PubMed:: 16176150
: https://doi.org/10.1089/jmf.2005.8.377

5. Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats

Author:: Annida, B.; Stanley Mainzen Prince, P.
Source:: Journal of medicinal food 2005 v.8 no.3 pp. 382-385
ISSN:: 1096-620X
Subject:: diabetes mellitus; lipid peroxidation; medicinal plants; heart; dietary supplements; oxidative stress; protective effect; glibenclamide; fenugreek; medicinal properties; animal disease models; herbal medicines; traditional medicine; leaves; glycemic effect; insulin; kidneys; rats; antioxidant activity; antioxidants; liver; streptozotocin; India
DOI:: 10.1089/jmf.2005.8.382
PubMed:: 16176151
: https://doi.org/10.1089/jmf.2005.8.382

6. Antidiabetic activity of some Indian medicinal plants

Author:: Rafiullah, M.R.M.; Siddiqui, A.W.; Mir, S.R.; Ali, M.; Pillai, K.K.; Singh, S.
Source:: Pharmaceutical biology 2006 v.44 no.2 pp. 95-99
ISSN:: 1388-0209
Subject:: medicinal plants; herbal medicines; traditional medicine; glycemic effect; plant extracts; rats; animal disease models; diabetes; glucose tolerance; blood glucose; duration; India
DOI:: 10.1080/13880200600591972
: https://doi.org/10.1080/13880200600591972

7. Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes

Author:: Liu, C.T.; Wong, P.L.; Lii, C.K.; Hse, H.; Sheen, L.Y.
Source:: Food and chemical toxicology 2006 v.44 no.8 pp. 1377-1384
ISSN:: 0278-6915
Subject:: garlic; Allium sativum; plant extracts; essential oils; diallyl sulfides; glycemic control; glycemic effect; renal function; rats; animal disease models; oxidative stress; streptozotocin; noninsulin-dependent diabetes mellitus; nutritional intervention; dosage; long term effects; glucose tolerance; blood glucose; body weight; weight gain
DOI:: 10.1016/j.fct.2005.07.013
PubMed:: 16690190
: https://doi.org/10.1016/j.fct.2005.07.013

8. Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia platycarpa

Author:: Narvaez-Mastache, J.M.; Garduno-Ramirez, M.L.; Alvarez, L.; Delgado, G.
Source:: Journal of natural products 2006 v.69 no.12 pp. 1687-1691
ISSN:: 0163-3864
Subject:: traditional medicine; flavones; Fabaceae; glycemic effect; medicinal plants; plant extracts; blood glucose; diabetes mellitus; spectral analysis; chemical constituents of plants; chemical structure; animal disease models; rats; Mexico
DOI:: 10.1021/np060166z
PubMed:: 17190443
: https://doi.org/10.1021/np060166z

9. Dietary caloric restriction modifies inflammatory responses in the livers of streptozotocin-induced diabetic rats

Author:: Ugochukwu, N.H.; Figgers, C.L.
Source:: Nutrition research 2006 v.26 no.5 pp. 221-226
ISSN:: 0271-5317
Subject:: rats; animal disease models; oxidative stress; noninsulin-dependent diabetes mellitus; streptozotocin; insulin resistance; liver function; very low calorie diet; nutritional intervention; glycemic control; glycemic effect; glucose tolerance; anti-inflammatory activity; haptoglobins; interleukin-1; interleukin-10; tumor necrosis factor-alpha; interleukin-4; interleukin-6; adipose tissue; inflammation; nutrition-genotype interaction
Abstract:: ... Chronic systemic low-grade inflammation plays a key role in the development of insulin resistance, a hallmark of type 2 diabetes. Caloric restriction has been shown to improve glycemic control in diabetes and moderate expression of some markers of inflammation that are up-regulated during aging. Forty male Wistar rats were subjected to 30% caloric restriction (20 animals) and ad libitum feeding (2 ...
DOI:: 10.1016/j.nutres.2006.05.003
: https://doi.org/10.1016/j.nutres.2006.05.003

10. Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models

Author:: Ojewole, J.A.O.; Drewes, S.E.; Khan, F.
Source:: Phytochemistry 2006 v.67 no.6 pp. 610-617
ISSN:: 0031-9422
Subject:: glucose tolerance; vasodilator agents; hypoglycemic agents; isoflavones; portal vein; pyrans; medicinal plants; glycemic effect; blood glucose; human health; rootstocks; vasodilation; rats; Eriosema; animal disease models; South Africa
Abstract:: ... Zulu traditional health practitioners have claimed that the roots of Eriosema kraussianum N. E. Br. (Fabaceae) and other Eriosema species (Zulu indigenous umbrella name of "uBangalala") are effective remedies for the treatment of erectile dysfunction (ED) and/or impotence. In order to scientifically appraise the significance and contribution of Eriosema kraussianum to its ethnomedical use as "uBan ...
DOI:: 10.1016/j.phytochem.2005.11.019
PubMed:: 16434072
: https://doi.org/10.1016/j.phytochem.2005.11.019

11. A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats

Author:: Shih, C.K.; Chen, S.H.; Hou, W.C.; Cheng, H.H.
Source:: Food research international 2007 v.40 no.7 pp. 842-847
ISSN:: 0963-9969
Subject:: noninsulin-dependent diabetes mellitus; oxidative stress; malondialdehyde; insulin secretion; animal disease models; blood serum; glycemic index; superoxide dismutase; glycemic effect; resistant starch; rats; antioxidant activity; glycemic control; high carbohydrate diet; free radicals; glycosylation; rice starch; hemoglobin; streptozotocin; free radical scavengers; cholesterol
Abstract:: ... Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means +/- SD) under the glucose curve of cornstar ...
DOI:: 10.1016/j.foodres.2007.01.015
: https://doi.org/10.1016/j.foodres.2007.01.015

12. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats

Author:: Yadav, H.; Jain, S.; Sinha, P.R.
Source:: Nutrition 2007 v.23 no.1 pp. 62-68
ISSN:: 0899-9007
Subject:: probiotics; lactic acid bacteria; Lactobacillus acidophilus; Lactobacillus casei; glycemic control; glycemic effect; rats; animal disease models; high carbohydrate diet; fructose; noninsulin-dependent diabetes mellitus; fermented milk; traditional foods; nutritional intervention; food intake; glucose tolerance; blood glucose; insulin; blood lipids; oxidative stress; antioxidant activity; disease prevention; health promotion; health foods; India
DOI:: 10.1016/j.nut.2006.09.002
PubMed:: 17084593
: https://doi.org/10.1016/j.nut.2006.09.002

13. Antidiabetic properties of selected Mexican copalchis of the Rubiaceae family

Author:: Guerrero-Analco, J.; Medina-Campos, O.; Brindis, F.; Bye, R.; Pedraza-Chaverri, J.; Navarrete, A.; Mata, R.
Source:: Phytochemistry 2007 v.68 no.15 pp. 2087-2095
ISSN:: 0031-9422
Subject:: Rubiaceae; glycemic effect; rats; animal disease models; insulin; glycogen; human health; Mexico
Abstract:: ... The extracts prepared from the stem barks of several Mexican copalchis species, including Hintonia latiflora, Exostema caribaeum and a commercial mixture of Hintonia standleyana and E. caribaeum (CM) showed significant hypoglycemic and antihyperglycemic effects. The extracts were tested in three different in vivo models using normal and streptozotocin (STZ)-induced diabetic rats. From the active e ...
DOI:: 10.1016/j.phytochem.2007.05.006
PubMed:: 17575991
: https://doi.org/10.1016/j.phytochem.2007.05.006

14. Antihyperglycemic Effects of Platycodon grandiflorum (Jacq.) A. DC. Extract on Streptozotocin-induced Diabetic Mice

Author:: Zheng, Jie; He, Jiguo; Ji, Baoping; Li, Ye; Zhang, Xiaofeng
Source:: Plant foods for human nutrition 2007 v.62 no.1 pp. 7-11
ISSN:: 0921-9668
Subject:: body weight; diabetes mellitus; blood glucose; glycemic effect; glibenclamide; streptozotocin; mice; insulin secretion; insulin; glucose tolerance tests; Platycodon grandiflorus; animal disease models
Abstract:: ... The root of Platycodon grandiflorum (Jacq.) A. DC has been reported to have a wide range of health benefits in oriental food. This study examined the hypoglycemic effects of Platycodon grandiflorum (Jacq.) A. DC aqueous-ethanol extract (PGE) in streptozotocin (STZ) -induced diabetic ICR mice (STZ diabetic mice) for the first time. The effects of PGE on blood glucose, plasma insulin levels and body ...
DOI:: 10.1007/s11130-006-0034-4
PubMed:: 17226070
: https://doi.org/10.1007/s11130-006-0034-4

15. Antihyperglycemic Property of Tragia cannabina in Streptozotocin-Induced Diabetic Rats

Author:: Sivajothi, V.; Dey, A.; Jayakar, B.; Rajkapoor, B.
Source:: Journal of medicinal food 2007 v.10 no.2 pp. 361-365
ISSN:: 1096-620X
Subject:: rats; animal disease models; diabetes mellitus; glycemic effect; hypoglycemic agents; Euphorbiaceae; roots; medicinal properties; medicinal plants; plant extracts; blood glucose; oral administration; blood lipids; cholesterol; triacylglycerols; high density lipoprotein; biomarkers; blood proteins; enzyme activity; antioxidant activity; histopathology; liver; kidneys; traditional medicine
DOI:: 10.1089/jmf.2006.030
PubMed:: 17651075
: https://doi.org/10.1089/jmf.2006.030

16. Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats

Author:: Zhang, Y.H.; Cai, J.Y.; Pi, H.F.; Wu, J.Z.
Source:: Journal of ethnopharmacology 2007 v.114 no.2 pp. 141-145
ISSN:: 0378-8741
Subject:: glycemic effect; yields; chemical constituents of plants; rats; streptozotocin; animal disease models; diabetes; oral administration; dose response; antioxidants; nitric oxide; islets of Langerhans; glucose tolerance
DOI:: 10.1016/j.jep.2007.05.022
: https://doi.org/10.1016/j.jep.2007.05.022

17. Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats

Author:: Singh, S.K.; Kesari, A.N.; Gupta, R.K.; Jaiswal, D.; Watal, G.
Source:: Journal of ethnopharmacology 2007 v.114 no.2 pp. 174-179
ISSN:: 0378-8741
Subject:: high density lipoprotein; hypoglycemic agents; dose response; blood serum; urine; Cynodon dactylon; sugars; body weight; glycemic effect; plant extracts; blood glucose; streptozotocin; cholesterol; low density lipoprotein; triacylglycerols; rats; oral administration; animal disease models
DOI:: 10.1016/j.jep.2007.07.039
: https://doi.org/10.1016/j.jep.2007.07.039

18. Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats

Author:: Xi, L.; Qian, Z.; Xu, G.; Zheng, S.; Sun, S.; Wen, N.; Sheng, L.; Shi, Y.; Zhang, Y.
Source:: Journal of nutritional biochemistry 2007 v.18 no.1 pp. 64-72
ISSN:: 0955-2863
Subject:: anti-inflammatory activity; adiponectin; leptin; free fatty acids; essential oils; plant extracts; artificial colors; saffron; health foods; insulin resistance; carotenoids; fructose; animal disease models; epididymis; body weight; glycemic effect; tumor necrosis factor-alpha; Crocus sativus; rats; antioxidant activity; glycemic control; high carbohydrate diet; free radical scavengers; white adipose tissue; portal hypertension; hyperinsulinemia
Abstract:: ... Crocetin, a unique carotenoid with potent antioxidative and anti-inflammatory activities, is a major ingredient of saffron which is used as an important spice and food colorant in various parts of the world. In the present study, the effect of crocetin on insulin resistance and its related abnormalities induced by high-fructose diet were investigated in male Wistar rats. Compared to the control ra ...
DOI:: 10.1016/j.jnutbio.2006.03.010
PubMed:: 16713230
: https://doi.org/10.1016/j.jnutbio.2006.03.010

19. Changes in Glycoprotein Components in Streptozotocin - Nicotinamide Induced Type 2 Diabetes: Influence of Tetrahydrocurcumin from Curcuma longa

Author:: PARI, LEELAVINOTHAN; MURUGAN, PIDARAN
Source:: Plant foods for human nutrition 2007 v.62 no.1 pp. 25-29
ISSN:: 0921-9668
Subject:: Curcuma longa; animal disease models; antineoplastic agents; antioxidant activity; blood glucose; curcumin; fucose; glucose; glycemic effect; glycoproteins; hexosamines; insulin; metabolites; nicotinamide; noninsulin-dependent diabetes mellitus; oral administration; rats; sialic acids; streptozotocin; tissues
Abstract:: ... Curcuma longa (Zingiberaceae) has been used traditionally as antidiabetic, and has been proven scientifically to possess high antioxidant activity and anticancer properties. The active components of Curcuma longa such as curcumin and tetrahydrocurcumin (THC), a major colourless metabolite of curcumin also possesses antidiabetic, antiinflammatory and antioxidant activity. The ethnopharmacological v ...
DOI:: 10.1007/s11130-006-0037-1
PubMed:: 17226069
: https://doi.org/10.1007/s11130-006-0037-1

20. Constituents of Ocimum sanctum with Antistress Activity

Author:: Gupta, P.; Yadav, D.K.; Siripurapu, K.B.; Palit, G.; Maurya, R.
Source:: Journal of natural products 2007 v.70 no.9 pp. 1410-1416
ISSN:: 0163-3864
Subject:: animal disease models; Ocimum tenuiflorum; basil; medicinal plants; psychological stress; glycemic effect; corticosterone; creatine kinase; spectral analysis; chemical constituents of plants; mental health; chemical structure; Oriental traditional medicine; rats; India
DOI:: 10.1021/np0700164
PubMed:: 17850106
: https://doi.org/10.1021/np0700164

21. D-chiro-inositol found in momordica charantia fruit extract plays a role in reducing blood glucose in streptozotocin-diabetic rats

Author:: XIA, TAO; WANG, QIN
Source:: Journal of food biochemistry 2007 v.31 no.4 pp. 551-562
ISSN:: 0145-8884
Subject:: oral administration; mechanism of action; patients; blood plasma; Momordica charantia; animal disease models; body weight; myo-inositol; blood glucose; glycemic effect; insulin; diabetes; rats; glucose tolerance; fruits; fruit extracts; streptozotocin; food availability; diet therapy; South Africa; South America; Asia
Abstract:: ... Momordica charantia, commonly known as bitter gourd, has been shown to possess hypoglycemic activity. However, the mechanism of its action is not known. Chemically synthesized d-chiro-inositol ( d-CI), the component of insulin mediators, has been demonstrated to have antihyperglycemic effects in rats. In this study, we found that M. charantia fruit contains relatively high levels of d-CI; thus, it ...
DOI:: 10.1111/j.1745-4514.2007.00129.x
: https://doi.org/10.1111/j.1745-4514.2007.00129.x

22. Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice

Author:: Tomaru, M.; Takano, H.; Osakabe, N.; Yasuda, A.; Inoue, K.; Yanagisawa, R.; Ohwatari, T.; Uematsu, H.
Source:: Nutrition 2007 v.23 no.4 pp. 351-355
ISSN:: 0899-9007
Subject:: glucose tolerance; food intake; proanthocyanidins; glycemic effect; blood glucose; mice; cocoa powder; noninsulin-dependent diabetes mellitus; obesity; hyperglycemia; antioxidant activity; antioxidants; animal disease models; dietary supplements
DOI:: 10.1016/j.nut.2007.01.007
PubMed:: 17350804
: https://doi.org/10.1016/j.nut.2007.01.007

23. Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro

Author:: Govindarajan, R.; Asare-Anane, H.; Persaud, S.; Jones, P.; Houghton, P.J.
Source:: Planta medica 2007 v.73 no.5 pp. 427-432
ISSN:: 0032-0943
Subject:: Desmodium gangeticum; diabetes; high density lipoprotein; caffeic acid; glycemic effect; medicinal plants; blood glucose; blood plasma; triacylglycerols; cholesterol; insulin secretion; flavonoids; chlorogenic acid; animal disease models; rats; India
DOI:: 10.1055/s-2007-967176
PubMed:: 17431824
: https://doi.org/10.1055/s-2007-967176

24. Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats

Author:: Eidi, A.; Eidi, M.; Sokhteh, M.
Source:: Nutrition research 2007 v.27 no.11 pp. 728-733
ISSN:: 0271-5317
Subject:: aspartate transaminase; medicinal plants; noninsulin-dependent diabetes mellitus; creatinine; Trigonella foenum-graecum; fenugreek; animal disease models; herbal medicines; blood lipids; seeds; blood serum; glycemic effect; blood glucose; triacylglycerols; insulin; rats; ethanol; supercritical fluid extraction; seed extracts; uric acid; streptozotocin; cholesterol; urea
Abstract:: ... Many herbal medicines have been recommended for the treatment of diabetes. The antidiabetic effect of fenugreek ethanolic extract (Trigonella-foenum graecum L) was investigated in normal and streptozotocin-induced diabetic rats. Oral administration of fenugreek extract (0.1, 0.25, and 0.5 g/kg body weight) for 14 days on the level of serum glucose, total cholesterol, triacylglycerol, urea, uric ac ...
DOI:: 10.1016/j.nutres.2007.09.006
: https://doi.org/10.1016/j.nutres.2007.09.006

25. Ethanol extract of Gymnema montanum leaves reduces glycoprotein components in experimental diabetes

Author:: Ramkumar, K.M.; Rajaguru, P.; Latha, M.; Ananthan, R.
Source:: Nutrition research 2007 v.27 no.2 pp. 97-103
ISSN:: 0271-5317
Subject:: sialic acids; essential oils; plant extracts; medicinal plants; noninsulin-dependent diabetes mellitus; fucose; hexoses; hyperglycemia; glycoproteins; animal disease models; leaves; hexosamines; Gymnema; glycemic effect; blood glucose; insulin; kidneys; rats; ethanol; glucose tolerance; supercritical fluid extraction; glycemic control; liver
Abstract:: ... In the present study, the modulatory effects of Gymnema montanum leaves on glycoprotein levels in alloxan-induced diabetic rats were examined. The ethanol extract of G montanum leaves was administered orally (200 mg/kg of body weight) for 3 weeks. The effect of G montanum leaves on blood glucose, plasma insulin, and plasma/tissue glycoproteins was compared with that of a reference drug, glibenclam ...
DOI:: 10.1016/j.nutres.2006.12.010
: https://doi.org/10.1016/j.nutres.2006.12.010

26. Hypoglycaemic constituents of Stachytarpheta cayennensis leaf

Author:: Adebajo, A.C.; Olawode, E.O.; Omobuwajo, O.R.; Adesanya, S.A.; Begrow, F.; Elkhawad, A.; Akanmu, M.A.; Edrada, R.; Proksch, P.; Schmidt, T.J.
Source:: Planta medica 2007 v.73 no.3 pp. 241-250
ISSN:: 0032-0943
Subject:: phytochemicals; diabetes mellitus; glycemic effect; medicinal plants; plant extracts; hypoglycemia; human health; blood glucose; Stachytarpheta; rats; animal disease models; Nigeria
DOI:: 10.1055/s-2007-967125
PubMed:: 17318784
: https://doi.org/10.1055/s-2007-967125

27. Indian herbs result in hypoglycemic responses in streptozotocin-induced diabetic rats

Author:: Chandra, A.; Mahdi, A.A.; Ahmad, S.; Singh, R.K.
Source:: Nutrition research 2007 v.27 no.3 pp. 161-168
ISSN:: 0271-5317
Subject:: lipid peroxidation; medicinal plants; plant extracts; noninsulin-dependent diabetes mellitus; oxidative stress; Ocimum tenuiflorum; animal disease models; leaves; traditional medicine; herbal medicines; garlic; glycemic effect; rats; antioxidant activity; supercritical fluid extraction; glycemic control; free radicals; Azadirachta indica; Allium sativum; streptozotocin; free radical scavengers; India
Abstract:: ... The main aim of this study was to evaluate the protective effect of selected Indian herbal hypoglycemic agents on oxidative stress and antioxidant status in streptozotocin-induced diabetic rats. Oral administration of aqueous extracts of Momordica charantia, Allium sativum, Azadirachta indica, and Ocimum sanctum led to marked lowering of blood sugar level in diabetic rats. Free radical-induced lip ...
DOI:: 10.1016/j.nutres.2006.12.008
: https://doi.org/10.1016/j.nutres.2006.12.008

28. Monoglycerides and fatty acids from Ibervillea sonorae root: isolation and hypoglycemic activity

Author:: Hernandez-Galicia, E.; Calzada, F.; Roman-Ramos, R.; Alarcon-Aguilar, F.J.
Source:: Planta medica 2007 v.73 no.3 pp. 236-240
ISSN:: 0032-0943
Subject:: fatty acids; monoacylglycerols; glycemic effect; mice; Ibervillea sonorae; spectral analysis; chemical structure; animal disease models
DOI:: 10.1055/s-2007-967117
PubMed:: 17318782
: https://doi.org/10.1055/s-2007-967117

29. The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice

Author:: Jung, U.J.; Baek, N.l.; Chung, H.G.; Bang, M.H.; Yoo, J.S.; Jeong, T.S.; Lee, K.T.; Kang, Y.J.; Lee, M.K.; Kim, H.J.
Source:: Food and chemical toxicology 2007 v.45 no.10 pp. 2022-2029
ISSN:: 0278-6915
Subject:: leptin; medicinal plants; plant extracts; noninsulin-dependent diabetes mellitus; glucagon; insulin resistance; glycolysis; animal disease models; blood serum; glycemic effect; blood glucose; mice; Artemisia indica var. maximowiczii; enzyme activity; ethanol; glucose tolerance; supercritical fluid extraction; glycemic control; glycosylation; c-peptide; glucose-6-phosphatase
DOI:: 10.1016/j.fct.2007.04.021
PubMed:: 17574717
: https://doi.org/10.1016/j.fct.2007.04.021

30. Animal models to test drugs with potential antidiabetic activity

Author:: Fröde, T.S.; Medeiros, Y.S.
Source:: Journal of ethnopharmacology 2008 v.115 no.2 pp. 173-183
ISSN:: 0378-8741
Subject:: animal disease models; herbal medicines; therapeutics; diabetes mellitus; hypoglycemic agents; glycemic effect; product development; laboratory techniques; pathogenesis; mechanism of action; meta-analysis; experimental design
Abstract:: ... Although medicinal plants have been historically used for diabetes treatment throughout the world, few of them have been validated by scientific criteria. Recently, a large diversity of animal models has been developed to better understand the pathogenesis of diabetes mellitus and new drugs have been introduced in the market to treat this disease. The aim of this work was to review the available a ...
DOI:: 10.1016/j.jep.2007.10.038
: https://doi.org/10.1016/j.jep.2007.10.038

31. Anti-diabetic Effects of Cesium Aqua (N,N′-ethylene(salicylideneiminato)-5-sulfonato) Oxovanadium (IV) Dihydrate in Streptozotocin-induced Diabetic Rats

Author:: Ming Li; Dan Wei; Wenjun Ding; Bharat Baruah; Debbie C. Crans
Source:: Biological trace element research 2008 v.121 no.3 pp. 226-232
ISSN:: 0163-4984
Subject:: animal disease models; aspartate transaminase; blood glucose; blood serum; cesium; diabetes; drinking water; glucose tolerance; glycemic effect; glycogen; hyperglycemia; liver; rats; therapeutics; urea nitrogen; vanadium
Abstract:: ... The study has been designed to investigate the anti-diabetic effects of cesium aqua (N,N′-ethylene (salicylideneiminato)-5-sulfonato) oxovanadium (IV) dihydrate (VO(salen-SO₃)), an organic vanadium compound, in streptozotocin-induced diabetic rats. VO(salen-SO₃) was orally administrated to diabetic rats at the dose of 0.3 mg/ml through drinking water for 24 days. Blood glucose level was significan ...
DOI:: 10.1007/s12011-007-8049-8
: https://doi.org/10.1007/s12011-007-8049-8

32. Antidiabetic and Antioxidant Effects of Polyphenols in Brown Alga Ecklonia stolonifera in Genetically Diabetic KK-Ay Mice

Author:: Iwai, Kunihisa
Source:: Plant foods for human nutrition 2008 v.63 no.4 pp. 163-169
ISSN:: 0921-9668
Subject:: Ecklonia; alpha-glucosidase; animal disease models; antioxidant activity; blood glucose; cost effectiveness; diabetes mellitus; food intake; glycemic effect; health foods; hyperglycemia; ingestion; lipid peroxidation; macroalgae; males; maltose; mice; oral administration; patients; polyphenols
Abstract:: ... The dietary intake and control of blood glucose levels are very important in hyperglycemic patients and α-glucosidase inhibitors are a cost-effective means to preventing the progression of diabetes. In search of a natural inhibitor from food materials, α-glucosidase inhibitory activity and the anti-hyperglycemic effects of a brown alga, Ecklonia stolonifera, were investigated using non-insulin dep ...
DOI:: 10.1007/s11130-008-0098-4
PubMed:: 18958624
: https://doi.org/10.1007/s11130-008-0098-4

33. Antihyperglycemic Effect of Stem Bark Powder from Paper Mulberry (Broussonetia kazinoki Sieb.) in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats

Author:: Cha, Jae Young; Kim, Yong Taek; Kim, Hyeong Soo; Cho, Young Su
Source:: Journal of medicinal food 2008 v.11 no.3 pp. 499-505
ISSN:: 1096-620X
Subject:: rats; animal disease models; glycemic effect; cholesteremic effect; Broussonetia; medicinal plants; medicinal properties; bark; powders; noninsulin-dependent diabetes mellitus; blood glucose; insulin; blood lipids; enzyme activity; liver; biomarkers; drinking water; triacylglycerols; cholesterol; high density lipoprotein; alanine transaminase; aspartate transaminase
DOI:: 10.1089/jmf.2007.0028
PubMed:: 18800898
: https://doi.org/10.1089/jmf.2007.0028

34. Antihyperglycemic profile of Trichosanthes dioica seeds in experimental models

Author:: Rai, Prashant Kumar; Jaiswal, Dolly; Diwakar, Sandhya; Watal, Geeta
Source:: Pharmaceutical biology 2008 v.46 no.5 pp. 360-365
ISSN:: 1388-0209
Subject:: Trichosanthes dioica; seed extracts; diabetes mellitus; glycemic effect; animal disease models; medicinal plants; traditional medicine; oral administration; blood glucose; glucose tolerance; dose response; rats; India
DOI:: 10.1080/13880200801888011
: https://doi.org/10.1080/13880200801888011

35. Comparison between ethanolic and aqueous extracts from Chinese juniper berries for hypoglycaemic and hypolipidemic effects in alloxan-induced diabetic rats

Author:: Ju, J.B.; Kim, J.S.; Choi, C.W.; Lee, H.K.; Oh, T.K.; Kim, S.C.
Source:: Journal of ethnopharmacology 2008 v.115 no.1 pp. 110-115
ISSN:: 0378-8741
Subject:: human diseases; diabetes; aqueous solutions; small fruits; alanine transaminase; glycemic effect; medicinal plants; plant extracts; Juniperus chinensis; alloxan; blood glucose; cholesterol; triacylglycerols; rats; lipemic effect; oral administration; ethanol; animal disease models
Abstract:: ... Aim of the study: Hypoglycaemic and hypolipidemic properties of the ethanolic and aqueous extracts, respectively, from Chinese juniper (Juniperus chinensis L.) berries were investigated in alloxan-induced diabetic rats. Materials and methods: After oral administration of each extract singly or repeatedly to alloxan-induced diabetic rats, the blood glucose, glutamate-pyruvate transferase (GPT), glu ...
DOI:: 10.1016/j.jep.2007.09.012
: https://doi.org/10.1016/j.jep.2007.09.012

36. Effect of Andrographolide and Ethanol Extract of Andrographis paniculata on Liver Glycolytic, Gluconeogenic, and Lipogenic Enzymes in a Type 2 Diabetic Rat Model

Author:: Subramanian, Rammohan; Asmawi, M.Z.; Sadikun, Amirin
Source:: Pharmaceutical biology 2008 v.46 no.10-11 pp. 772-780
ISSN:: 1388-0209
Subject:: medicinal plants; plant extracts; noninsulin-dependent diabetes mellitus; lipemic effect; Andrographis paniculata; hexokinase; glycolysis; lactate dehydrogenase; animal disease models; traditional medicine; blood serum; glycemic effect; insulin; rats; glucokinase; ethanol; antioxidants; nicotinamide; hypoglycemic agents; liver; streptozotocin; chemical constituents of plants; India; Malaysia
DOI:: 10.1080/13880200802316079
: https://doi.org/10.1080/13880200802316079

37. Effect of Lepidium sativum L. on renal glucose reabsorption and urinary TGF-β1 levels in diabetic rats

Author:: Eddouks, Mohamed; Maghrani, Mhamed
Source:: Phytotherapy research 2008 v.22 no.1 pp. 1-5
ISSN:: 0951-418X
Subject:: Lepidium sativum; animal disease models; blood glucose; diabetes mellitus; enzyme-linked immunosorbent assay; glucose; glycemic effect; glycosuria; insulin; oral administration; plant extracts; rats; reducing sugars; renal function; transforming growth factor beta
Abstract:: ... The purpose of this study was to determine the mechanism underlying the hypoglycaemic activity of the aqueous extract perfusion of Lepidium sativum L. (LS) in normal and streptozotocin-induced diabetic rats. The aqueous LS extract was administered intravenously and the blood glucose levels were determined within 4 h of treatment. Plasma insulin concentrations and glycosuria were determined. The 24 ...
DOI:: 10.1002/ptr.2101
: https://doi.org/10.1002/ptr.2101

38. Effect of Picrorrhiza Rhizoma Extracts on Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats

Author:: Lee, H.S.; Ku, S.K.
Source:: Journal of medicinal food 2008 v.11 no.2 pp. 294-301
ISSN:: 1096-620X
Subject:: diabetic nephropathy; tissue weight; Picrorhiza; glycemic effect; medicinal plants; plant extracts; blood glucose; creatinine; kidneys; rats; medicinal properties; urea nitrogen; rhizomes; histopathology; animal disease models; protective effect
DOI:: 10.1089/jmf.2007.578
PubMed:: 18598172
: https://doi.org/10.1089/jmf.2007.578

39. Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction

Author:: Zhang, L.; Zhang, Y.; Xia, Q.; Zhao, X.M.; Cai, H.X.; Li, D.W.; Yang, X.D.; Wang, K.; Xia, Z.L.
Source:: Food and chemical toxicology 2008 v.46 no.9 pp. 2996-3002
ISSN:: 0278-6915
Subject:: herbal medicines; vanadium; glycemic effect; Salvia miltiorrhiza; medicinal plants; Oriental traditional medicine; plant extracts; toxicity testing; rats; animal disease models; oxidative stress; oral administration; noninsulin-dependent diabetes mellitus; blood glucose; hyperglycemia; islets of Langerhans; streptozotocin; glucose tolerance; glycemic index
DOI:: 10.1016/j.fct.2008.05.040
PubMed:: 18601969
: https://doi.org/10.1016/j.fct.2008.05.040

40. Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

Author:: Gokce, G.; Haznedaroglu, M.Z.
Source:: Journal of ethnopharmacology 2008 v.115 no.1 pp. 122-130
ISSN:: 0378-8741
Subject:: Posidoniaceae; traditional medicine; alloxan; hypoglycemic agents; plant extracts; diabetes mellitus; hypertension; oral administration; medicinal plants; acetylcholine; aorta; serotonin; antioxidants; chemical concentration; phenylephrine; human diseases; antioxidant activity; protective effect; glycemic effect; dose response; blood glucose; hemodynamics; glutathione; superoxide dismutase; glutathione peroxidase; catalase; nitric oxide; liver function; renal function; leukocyte count; body weight; glycogen; liver; rats; animal disease models; Mediterranean Sea; Turkey (country)
Abstract:: ... The aim of this study is to evaluate antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract (POE) in alloxan diabetic rats. Posidonia oceanica (L) Delile (Posidoniaceae), is a widely allocated phanerogam in Mediterranean and Aegean Sea. Up to date, no published data relevant to use of the plant in traditional medicine are available. However, decoction of the leaves has ...
DOI:: 10.1016/j.jep.2007.09.016
: https://doi.org/10.1016/j.jep.2007.09.016

41. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates

Author:: Kavanagh, Kylie; Jones, Kate L.; Zhang, Li; Flynn, David. M.; Shadoan, Melanie K.; Wagner, Janice D.
Source:: Nutrition research 2008 v.28 no.6 pp. 368-376
ISSN:: 0271-5317
Subject:: women; menopause; hyperglycemia; insulin resistance; glucose tolerance; nutritional intervention; soybean products; isoflavones; glycemic control; glycemic effect; estrogenic properties; insulin secretion; monkeys; animal disease models; hyperinsulinemia; protein kinases; protein phosphorylation; females
Abstract:: ... Consuming soy and soy isoflavones has been shown to cause modest improvements in plasma lipids, lipoproteins, and indices of insulin sensitivity in postmenopausal women. The effect of soy on such end points is attributed often to estrogen receptor agonism by isoflavones. Recent in vitro studies suggest that isoflavones, in combination with high estrogen concentrations (within the range seen circul ...
DOI:: 10.1016/j.nutres.2008.03.011
: https://doi.org/10.1016/j.nutres.2008.03.011

42. Hypoglycemic and Antihyperglycemic Activity of Nymphaea stellata Flowers in Normal and Alloxan Diabetic Rats

Author:: Rajagopal, K.; Sasikala, K.; Ragavan, B.
Source:: Pharmaceutical biology 2008 v.46 no.9 pp. 654-659
ISSN:: 1388-0209
Subject:: glycemic effect; Nymphaea; flowers; laboratory animals; rats; animal disease models; diabetes mellitus; alloxan; plant extracts; oral administration; dose response; glucose tolerance; hyperglycemia; hypoglycemia; medicinal plants; traditional medicine; India
DOI:: 10.1080/13880200802182554
: https://doi.org/10.1080/13880200802182554

43. Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats

Author:: Niu, H.S.; Liu, I.M.; Cheng, J.T.; Lin, C.L.; Hsu, F.L.
Source:: Planta medica 2008 v.74 no.2 pp. 109-113
ISSN:: 0032-0943
Subject:: hepatocytes; phenylpropanoids; Eleutherococcus senticosus; diabetes mellitus; glycemic effect; medicinal plants; blood glucose; glycogen; human health; Oriental traditional medicine; cultured cells; rats; medicinal properties; glycosides; animal disease models
DOI:: 10.1055/s-2008-1034275
PubMed:: 18203055
: https://doi.org/10.1055/s-2008-1034275

44. Insulinomimetic Effect of Kaempferol 3-Neohesperidoside on the Rat Soleus Muscle

Author:: Zanatta, L.; Rosso, A.; Folador, P.; Figueiredo, M.S.R.B.; Pizzolatti, M.G.; Leite, L.D.; Silva, F.R.M.B.
Source:: Journal of natural products 2008 v.71 no.4 pp. 532-535
ISSN:: 0163-3864
Subject:: Cyathea; kaempferol; glycosides; medicinal properties; glycemic effect; biochemical pathways; rats; animal disease models; skeletal muscle; blood glucose; nutrient uptake; signal transduction; protein kinase C; mitogen-activated protein kinase; protein synthesis; glycogen; glucose transporters; diabetes mellitus; human health; Brazil
DOI:: 10.1021/np070358+
PubMed:: 18303854
: https://doi.org/10.1021/np070358+

45. Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice

Author:: Qi, Xiang-Yang; Chen, Wei-Jun; Zhang, Li-Qin; Xie, Bi-Jun
Source:: Nutrition research 2008 v.28 no.4 pp. 278-284
ISSN:: 0271-5317
Subject:: nutrient intake; glucose tolerance; high density lipoprotein; blood lipids; free radicals; phytochemicals; fruit extracts; medicinal plants; glycemic effect; mice; free radical scavengers; noninsulin-dependent diabetes mellitus; insulin resistance; cholesteremic effect; fruit composition; low density lipoprotein; hypolipidemia; antioxidant activity; animal disease models
Abstract:: ... This study evaluated the supplementation of a mogrosides extract (MG) from fruits of Siraitia grosvenori on reducing oxidative stress, hyperglycemia, and hyperlipidemia in alloxan-induced diabetic mice. The oxygen free radical scavenging activity of MG was also assessed in vitro. After induction of diabetes, a significant increase in the levels of serum glucose, total cholesterol (TC), triacylglyc ...
DOI:: 10.1016/j.nutres.2008.02.008
PubMed:: 19083420
: https://doi.org/10.1016/j.nutres.2008.02.008

46. A mixture of Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces body weight gain, visceral fat accumulation, and total cholesterol and insulin increases in male Wistar fatty rats

Author:: Kishino, Eriko; Ito, Tetsuya; Fujita, Koki; Kiuchi, Yoshihiro
Source:: Nutrition research 2009 v.29 no.1 pp. 55-63
ISSN:: 0271-5317
Subject:: Celastraceae; medicinal plants; stems; plant extracts; aqueous concentrates; cyclodextrins; glycemic effect; glycemic index; cholesteremic effect; insulin resistance; rats; animal disease models; males; noninsulin-dependent diabetes mellitus; obesity; visceral fat; experimental diets; food intake; dietary fiber; glucose tolerance; rumen fermentation; cecum; butyrates; acetates; propionates; short chain fatty acids; liver; tissue weight; glycemic control; blood serum; blood glucose; blood lipids; cholesterol; insulin; triacylglycerols; high density lipoprotein; indigenous species; peroxisomes; adiponectin; weight loss; weight gain; India
Abstract:: ... This study examined the effects of a mixture of an aqueous extract of Salacia reticulata (Kotala himbutu) and cyclodextrin (SRCD) on various metabolic parameters and cecal fermentation in obese fa/fa male Wistar fatty rats, a model of type 2 diabetes mellitus. Wistar fatty rats were fed 0% (control group) or 0.2% SRCD-supplemented diets and weighed weekly. The plasma glucose, triacylglycerol, tota ...
DOI:: 10.1016/j.nutres.2008.11.001
PubMed:: 19185778
: https://doi.org/10.1016/j.nutres.2008.11.001

47. Anti-diabetic activity of Emblica officinalis in animal models

Author:: Mehta, Shikha; Singh, Rakesh Kumar; Jaiswal, Dolly; Rai, Prashant Kumar; Watal, Geeta
Source:: Pharmaceutical biology 2009 v.47 no.11 pp. 1050-1055
ISSN:: 1388-0209
Subject:: Phyllanthus emblica; seed extracts; hypoglycemic agents; glycemic effect; rats; noninsulin-dependent diabetes mellitus; streptozotocin; blood glucose; glucose tolerance; dose response; animal disease models; phytochemicals
DOI:: 10.3109/13880200902991532
: https://doi.org/10.3109/13880200902991532

48. Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice

Author:: Chen, Xianghong; Bai, Xue; Liu, Yihui; Tian, Luanyuan; Zhou, Jianqiu; Zhou, Qun; Fang, Jinbo; Chen, Jiachun
Source:: Journal of ethnopharmacology 2009 v.122 no.2 pp. 205-209
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; plant extracts; chemical constituents of plants; roots; Liriope spicata; medicinal plants; polysaccharides; glycemic effect; diabetes mellitus; animal disease models; mice; oral administration; dose response; blood glucose; glucose tolerance; insulin resistance; cholesterol; triacylglycerols; low density lipoprotein; high density lipoprotein; China
Abstract:: ... Aim of the study: The present study was designed to investigate the hypoglycemic and hypolipidemic effects of the water extract (WE) and crude polysaccharides (CPs) obtained from the tuberous root of Liriope spicata (Thund.) var. prolifera Y. T. Ma, which is widely used in prescriptions of traditional Chinese medicine for the treatment of diabetes mellitus. Materials and methods: WE and CPs were a ...
DOI:: 10.1016/j.jep.2009.01.016
: https://doi.org/10.1016/j.jep.2009.01.016

49. Anti-diabetic properties of three common Bidens pilosa variants in Taiwan

Author:: Chien, Shih-Chang; Young, Paul H.; Hsu, Yi-Jou; Chen, Chun-Houh; Tien, Yin-Jing; Shiu, Shang-Ying; Li, Tzu-Hsuan; Yang, Chi-Wen; Marimuthu, Palanisamy; Tsai, Feng-Liang Leo; Yang, Wen-Chin
Source:: Phytochemistry 2009 v.70 no.10 pp. 1246-1254
ISSN:: 0031-9422
Subject:: cluster analysis; medicinal plants; plant extracts; high performance liquid chromatography; noninsulin-dependent diabetes mellitus; mass spectrometry; plant taxonomy; human health; medicinal properties; animal disease models; human diseases; glycemic effect; blood glucose; mice; insulin; chemotaxonomy; polyacetylenes; supercritical fluid extraction; Bidens pilosa; chemical constituents of plants; gas chromatography; Taiwan
Abstract:: ... Bidens pilosa L. var. radiata (BPR), B. pilosa L. var. pilosa (BPP), and B. pilosa L. var. minor (BPM) are common variants of a plant often used as a folk remedy for diabetes in Taiwan. However, the three variants are often misidentified and little is known about their relative anti-diabetic efficacy and chemical composition. In this paper, we have first developed a method based on GC-MS and clust ...
DOI:: 10.1016/j.phytochem.2009.07.011
PubMed:: 19683775
: https://doi.org/10.1016/j.phytochem.2009.07.011

50. Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract

Author:: Hsu, Yi-Jou; Lee, Tsung-Han; Chang, Cicero Lee-Tian; Huang, Yuh-Ting; Yang, Wen-Chin
Source:: Journal of ethnopharmacology 2009 v.122 no.2 pp. 379-383
ISSN:: 0378-8741
Subject:: traditional medicine; Bidens pilosa; islets of Langerhans; glycemic effect; medicinal plants; hyperglycemia; plant extracts; mice; blood glucose; noninsulin-dependent diabetes mellitus; hemoglobin; insulin; streptozotocin; medicinal properties; oral administration; glucose tolerance; animal disease models; Taiwan
Abstract:: ... Aim of study: Bidens pilosa has traditionally been used as an anti-diabetic phytomedicine. However, its alleged benefits and mechanism remain elusive. This study aimed to evaluate the effect and action of Bidens pilosa water extract on type 2 diabetes. Materials and methods: A daily dose of Bidens pilosa water extract or glimepiride, a positive control, was given orally to C57BL/KsJ-db/db mice onc ...
DOI:: 10.1016/j.jep.2008.12.027
PubMed:: 19162158
: https://doi.org/10.1016/j.jep.2008.12.027

51. Antidiabetic activity of extracts and fraction of Zizyphus mauritiana

Author:: Jarald, E.E.; Joshi, S.B.; Jain, D.C.
Source:: Pharmaceutical biology 2009 v.47 no.4 pp. 328-334
ISSN:: 1388-0209
Subject:: Ziziphus mauritiana; fruit extracts; medicinal plants; traditional medicine; glycemic effect; diabetes; rats; glucose; hyperglycemia; animal disease models; dose response; petroleum; urea; creatinine; cholesterol; triacylglycerols; hemoglobin; high density lipoprotein; low density lipoprotein; India
DOI:: 10.1080/13880200902752488
: https://doi.org/10.1080/13880200902752488

52. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Author:: Bagri, Priyanka; Ali, Mohd.; Aeri, Vidhu; Bhowmik, Malay; Sultana, Shahnaz
Source:: Food and chemical toxicology 2009 v.47 no.1 pp. 50-54
ISSN:: 0278-6915
Subject:: pancreas; Punica granatum; lipid peroxidation; plant extracts; dietary supplements; fruit trees; cholesteremic effect; oxidative stress; glutathione; glutathione transferase; animal disease models; blood lipids; phytochemicals; superoxide dismutase; glycemic effect; blood glucose; rats; antioxidant activity; thiobarbituric acid-reactive substances; supercritical fluid extraction; glucose tolerance; glycemic control; high density lipoprotein; pomegranates; glutathione-disulfide reductase; very low density lipoprotein; flowers; streptozotocin; free radical scavengers; low density lipoprotein; glutathione peroxidase
DOI:: 10.1016/j.fct.2008.09.058
PubMed:: 18950673
: https://doi.org/10.1016/j.fct.2008.09.058

53. Antihyperglycemic and hypoglycemic activities of Phyllanthus debilis aqueous plant extract in mice

Author:: Wanniarachchi, Kasuni K.; Peiris, L. Dinithi C.; Ratnasooriya, W.D.
Source:: Pharmaceutical biology 2009 v.47 no.3 pp. 260-265
ISSN:: 1388-0209
Subject:: medicinal plants; medicinal properties; plant extracts; mice; Phyllanthus; glycemic effect; Ayurvedic medicine; diabetes mellitus; animal disease models; dose response; blood glucose; sucrose; glucose tolerance; erythrocyte count; high density lipoprotein; Sri Lanka
DOI:: 10.1080/13880200802435754
: https://doi.org/10.1080/13880200802435754

54. Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera

Author:: Rauter, Amélia P.; Martins, Alice; Lopes, Rui; Ferreira, Joana; Serralheiro, Luísa M.; Araújo, Maria-Eduarda; Borges, Carlos; Justino, Jorge; Silva, Filipa V.; Goulart, Margarida; Thomas-Oates, Jane; Rodrigues, João A.; Edwards, Emma; Noronha, João P.; Pinto, Rui; Mota-Filipe, Hélder
Source:: Journal of ethnopharmacology 2009 v.122 no.2 pp. 384-393
ISSN:: 0378-8741
Subject:: medicinal plants; medicinal properties; indigenous species; traditional medicine; diabetes; glycemic effect; hyperglycemia; plant extracts; butanol; antioxidant activity; acetylcholinesterase; enzyme inhibition; cytotoxicity; genotoxicity; mass spectrometry; high performance liquid chromatography; rats; animal disease models; chemical constituents of plants; flavonoids; free radical scavengers; Genista; in vitro studies; Madeira Islands; Portugal
Abstract:: ... Aim of the study: Genista tenera is a plant endemic to the island of Madeira and is used in folk medicine to control diabetes. In the present work we evaluate the antihyperglycaemic activity of its n-butanol extract and determine its chromatographic profile. In addition, this extract, the ethyl acetate and diethyl ether plant extracts were studied in order to assess the plant antioxidant and acety ...
DOI:: 10.1016/j.jep.2008.10.011
: https://doi.org/10.1016/j.jep.2008.10.011

55. Biochemical evaluation of antihyperglycemic and antioxidant nature of Psidium guajava leaves extract in streptozotocin-induced experimental diabetes in rats

Author:: Subramanian, S.; Haseena Banu, H.; Mookambika Ramya Bai, R.; Shanmugavalli, R.
Source:: Pharmaceutical biology 2009 v.47 no.4 pp. 298-303
ISSN:: 1388-0209
Subject:: diabetes mellitus; medicinal plants; plant extracts; creatinine; Psidium guajava; oral administration; glutathione transferase; hyperglycemia; animal disease models; leaves; superoxide dismutase; glycemic effect; blood glucose; insulin; rats; enzyme activity; antioxidant activity; antioxidants; liver; catalase; hemoglobin; streptozotocin; glutathione peroxidase; urea; Ayurvedic medicine; India
DOI:: 10.1080/13880200902748429
: https://doi.org/10.1080/13880200902748429

56. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers

Author:: Décordé, Kelly; Teissèdre, Pierre-Louis; Sutra, Thibault; Ventura, Emilie; Cristol, Jean-Paul; Rouanet, Jean-Max
Source:: Molecular nutrition & food research 2009 v.53 no.5 pp. 659-666
ISSN:: 1613-4125
Subject:: NAD (coenzyme); abdominal fat; adiponectin; animal disease models; biochemical pathways; biomarkers; blood glucose; glycemic effect; grape seed extract; hamsters; high fat diet; hormone secretion; hyperinsulinemia; insulin; insulin resistance; leptin; obesity; oxidative stress; polyphenols; superoxide anion; triacylglycerols; weight control; wine grapes
Abstract:: ... Studies reported the effects of polyphenols but not for grape polyphenols towards obesity. We analysed the effects of a polyphenolic grape seed extract (GSE) on obesity and oxidative stress in hamsters receiving a high-fat diet (HFD). Three groups of hamsters received a standard diet (STD), or a HFD plus a daily gavage with water (Control, HFD) or a solution of GSE (HFD + GSE) for 12 wk. Plasma gl ...
DOI:: 10.1002/mnfr.200800165
PubMed:: 19035554
: https://doi.org/10.1002/mnfr.200800165

57. Evaluation of antidiabetic activity of the seeds of Swietenia macrophylla in diabetic rats

Author:: Maiti, Anup; Dewanjee, Saikat; Kundu, Mintu; Mandal, Subhash C.
Source:: Pharmaceutical biology 2009 v.47 no.2 pp. 132-136
ISSN:: 1388-0209
Subject:: glycemic effect; seeds; traditional medicine; medicinal plants; Swietenia macrophylla; rats; animal disease models; seed extracts; streptozotocin; diabetes; dose response; glucose tolerance; blood glucose; cholesterol; triacylglycerols; glycogen; liver; body weight; India
DOI:: 10.1080/13880200802436703
: https://doi.org/10.1080/13880200802436703

58. Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species

Author:: Cristians, Sol; Guerrero-Analco, Jose A.; Perez-Vasquez, Araceli; Palacios-Espinosa, Francisco; Ciangherotti, Carlos; Bye, Robert; Mata, Rachel
Source:: Journal of natural products 2009 v.72 no.3 pp. 408-413
ISSN:: 0163-3864
Subject:: Rubiaceae; medicinal plants; traditional medicine; phytochemicals; coumarins; chemical structure; spectral analysis; glycemic effect; blood glucose; noninsulin-dependent diabetes mellitus; human diseases; animal disease models; rats; Mexico
DOI:: 10.1021/np800642d
PubMed:: 19140696
: https://doi.org/10.1021/np800642d

59. Hypoglycemic Polysaccharides from the Tuberous Root of Liriope spicata

Author:: Chen, Xianghong; Liu, Yihui; Bai, Xue; Wen, Li; Fang, Jinbo; Ye, Mao; Chen, Jiachun
Source:: Journal of natural products 2009 v.72 no.11 pp. 1988–1992
ISSN:: 0163-3864
Subject:: fructans; human diseases; glycosidic linkages; root systems; fructose; diabetes mellitus; glycemic effect; medicinal plants; human health; mice; medicinal properties; Liriope spicata; animal disease models; China
DOI:: 10.1021/np900346d
PubMed:: 19874043
: https://doi.org/10.1021/np900346d

60. Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae

Author:: Lü, H.; Chen, J.; Li, W.L.; Ren, B.R.; Wu, J.L.; Kang, H.Y.; Zhang, H.Q.; Adams, A.; De Kimpe, N.
Source:: Journal of ethnopharmacology 2009 v.122 no.3 pp. 486-491
ISSN:: 0378-8741
Subject:: glycemic effect; Eriobotrya japonica; Oriental traditional medicine; triterpene acids; medicinal plants; diabetes; mice; animal disease models; streptozotocin; alloxan; oral administration; proteins; cholesterol; triacylglycerols; superoxide dismutase; enzyme activity; insulin; China
Abstract:: ... For seeking the good natural material to develop new agent to treat diabetes, the total triterpene acid (TTA) fraction extracted from Folium Eriobotryae [leaves of Eriobotrya japonica (Thunb.) Lindl.] was evaluated for its hypoglycemic and hypolipidemic potential through normal, alloxan and streptozotocin-induced diabetic mice administered with graded oral doses (100, 200, 300mg/(kgday)) for 7 or ...
DOI:: 10.1016/j.jep.2009.01.030
PubMed:: 19429317
: https://doi.org/10.1016/j.jep.2009.01.030

61. Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor, Coprinus comatus, and Lenzites betulina isolates in streptozotocin-induced diabetic rats [Erratum: 2009 May, v. 47, no. 5, p. 471-472.]

Author:: Yamac, Mustafa; Zeytinoglu, Melih; Kanbak, Gungor; Bayramoglu, Gokhan; Senturk, Hakan
Source:: Pharmaceutical biology 2009 v.47 no.2 pp. 168-174
ISSN:: 1388-0209
Subject:: Coprinus; diabetes; islets of Langerhans; glycemic effect; blood glucose; medicinal plants; streptozotocin; Lenzites; polysaccharides; animal disease models; rats; Turkey (country)
DOI:: 10.1080/13880200802436950
: https://doi.org/10.1080/13880200802436950

62. Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse

Author:: Im, Ryanghyok; Mano, Hiroshi; Matsuura, Tomokazu; Nakatani, Sachie; Shimizu, Jun; Wada, Masahiro
Source:: Journal of ethnopharmacology 2009 v.121 no.2 pp. 234-240
ISSN:: 0378-8741
Subject:: Ayurvedic medicine; plant extracts; blood glucose; stems; mice; medicinal plants; Celastraceae; diabetes; glycemic effect; chemical constituents of plants; microarray technology; animal disease models; messenger RNA; India
Abstract:: ... Ethnopharmacological relevance: Kothala himbutu (Salacia reticulata) is a medicinal plant that has been used in Ayurvedic system of Indian and Sri Lankan traditional medicine to treat diabetes. Aim of the study: This study aimed to clarify the mechanism(s) by which aqueous extracts of Kothala himbutu (KTE) stems decreases fasting blood glucose levels. Materials and methods: Gene expression profile ...
DOI:: 10.1016/j.jep.2008.10.026
PubMed:: 19028559
: https://doi.org/10.1016/j.jep.2008.10.026

63. Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects

Author:: Adebajo, A.C.; Iwalewa, E.O.; Obuotor, E.M.; Ibikunle, G.F.; Omisore, N.O.; Adewunmi, C.O.; Obaparusi, O.O.; Klaes, M.; Adetogun, G.E.; Schmidt, T.J.; Verspohl, E.J.
Source:: Journal of ethnopharmacology 2009 v.122 no.1 pp. 10-19
ISSN:: 0378-8741
Subject:: anti-inflammatory activity; hepatitis; medicinal plants; plant extracts; malaria; antiprotozoal agents; Trichomonas; methylene chloride; animal disease models; bronchitis; traditional medicine; hepatoprotective effect; glycemic effect; insulin; rats; antioxidant activity; enzyme activity; methanol; Clausena lansium; bark; hepatotoxicity
Abstract:: ... Ethnopharmacological Relevance: Clausena lansium (Fool's Curry Leaf) is used for various ethnomedical conditions in some countries, including bronchitis, malaria, viral hepatitis, acute and chronic gastro-intestinal inflammation, and as a spicy substitute of the popular Curry leaf tree (Murraya koenigii). Aim of the study: This study was to evaluate the ethnomedical uses of the stem bark in inflam ...
DOI:: 10.1016/j.jep.2008.11.015
PubMed:: 19095054
: https://doi.org/10.1016/j.jep.2008.11.015

64. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats

Author:: Ramkumar, Kunga Mohan; Ponmanickam, Ponnirul; Velayuthaprabhu, Shanmugam; Archunan, Govindaraju; Rajaguru, Palanisamy
Source:: Food and chemical toxicology 2009 v.47 no.10 pp. 2516-2521
ISSN:: 0278-6915
Subject:: herbs; lipid peroxidation; medicinal plants; plant extracts; noninsulin-dependent diabetes mellitus; creatinine; glutathione transferase; animal disease models; herbal medicines; Gymnema; superoxide dismutase; glycemic effect; hypoglycemia; kidneys; rats; antioxidant activity; hydroperoxides; thiobarbituric acid-reactive substances; glycemic control; uric acid; catalase; free radical scavengers; glutathione peroxidase; urea; indigenous species; nephrotoxicity; Oriental traditional medicine; India
DOI:: 10.1016/j.fct.2009.07.010
PubMed:: 19616598
: https://doi.org/10.1016/j.fct.2009.07.010

65. Taurine supplementation modulates glucose homeostasis and islet function

Author:: Carneiro, Everardo M.; Latorraca, Marcia Q.; Araujo, Eliana; Beltrá, Marta; Oliveras, Maria J.; Navarro, Mónica; Berná, Genoveva; Bedoya, Francisco J.; Velloso, Licio A.; Soria, Bernat; Martín, Franz
Source:: Journal of nutritional biochemistry 2009 v.20 no.7 pp. 503-511
ISSN:: 0955-2863
Subject:: taurine; protein supplements; essential amino acids; glycemic control; blood glucose; glucose tolerance; homeostasis; noninsulin-dependent diabetes mellitus; insulin resistance; mice; animal disease models; islets of Langerhans; nutrient-nutrient interactions; gene overexpression; immunohistochemistry; protein phosphorylation; sulfonylureas; glycemic effect; polymerase chain reaction
Abstract:: ... Taurine is a conditionally essential amino acid for human that is involved in the control of glucose homeostasis; however, the mechanisms by which the amino acid affects blood glucose levels are unknown. Using an animal model, we have studied these mechanisms. Mice were supplemented with taurine for 30 d. Blood glucose homeostasis was assessed by intraperitoneal glucose tolerance tests (IPGTT). Is ...
DOI:: 10.1016/j.jnutbio.2008.05.008
PubMed:: 18708284
: https://doi.org/10.1016/j.jnutbio.2008.05.008

66. Antidiabetic and antihyperlipidemic activity of ethyl acetate:Isopropanol (1:1) fraction of Vernonia anthelmintica seeds in Streptozotocin induced diabetic rats

Author:: Fatima, Shaik Sameena; Rajasekhar, Maddirala Dilip; Kumar, Kondeti Vinay; Kumar, Mekala Thur Sampath; Babu, Kasetti Ramesh; Rao, Chippada Appa
Source:: Food and chemical toxicology 2010 v.48 no.2 pp. 495-501
ISSN:: 0278-6915
Subject:: rats; animal disease models; oxidative stress; streptozotocin; diabetes mellitus; dosage; Vernonia; seed extracts; glycemic effect; ethnobotany; cholesteremic effect; blood glucose; blood lipids; free fatty acids
Abstract:: ... Ethanolic extract prepared from the seeds of Vernonia anthelmintica was evaluated for its antihyperglycemic activity in STZ (Streptozotocin) induced diabetic rats. Administration of ethanolic extract at a dosage of 0.50 g/kg bw produced the maximum fall (82%) in the blood glucose levels in diabetic rats after 6 h of treatment. Bioassay-directed fractionation using silica gel column chromatography ...
DOI:: 10.1016/j.fct.2009.10.048
PubMed:: 19896519
: https://doi.org/10.1016/j.fct.2009.10.048

67. Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice

Author:: Xu, Xin; Pang, Chong; Yang, Chengjian; Zheng, Yitong; Xu, Hongyu; Lu, Zhenming; Xu, Zhenghong
Source:: International journal of medicinal mushrooms 2010 v.12 no.3 pp. 235-244
ISSN:: 1521-9437
Subject:: Inonotus obliquus; animal disease models; antioxidant activity; blood glucose; blood serum; body weight; catalase; culture media; diabetes mellitus; free fatty acids; glutathione peroxidase; glycemic effect; glycogen; high density lipoprotein cholesterol; insulin; liver; low density lipoprotein cholesterol; medicinal fungi; mice; response surface methodology; superoxide dismutase; tissues; triacylglycerols
Abstract:: ... The optimum conditions for the extraction of crude polysaccharides from dry matter of culture broth (DMCB) of Inonotus obliquus were determined by using response surface methodology (RSM). In alloxan-induced diabetic mice, treatment with polysaccharide extract from DMCB of I. obliquus (150 and 300 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, with percentage ...
DOI:: 10.1615/IntJMedMushr.v12.i3.20
: https://doi.org/10.1615/IntJMedMushr.v12.i3.20

68. Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats

Author:: Perez-Gutierrez, Rosa Martha; Muñiz-Ramirez, Alethia; Gomez Gomez, Yolanda; Bautista Ramírez, Esther
Source:: Plant foods for human nutrition 2010 v.65 no.4 pp. 350-357
ISSN:: 0921-9668
Subject:: Byrsonima crassifolia; advanced glycation end products; animal disease models; blood glucose; blood serum; catalase; chloroform; cholesterol; diabetes mellitus; fruits; glucokinase; glucose-6-phosphatase; glutathione; glycemic effect; glycogen; hexane; hyperinsulinemia; hyperlipidemia; hypoglycemic agents; inhibitory concentration 50; insulin; lipid peroxidation; liver; methanol; oral administration; rats; seeds; skeletal muscle; superoxide dismutase; thiobarbituric acid; triacylglycerols
Abstract:: ... The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscle ...
DOI:: 10.1007/s11130-010-0181-5
: https://doi.org/10.1007/s11130-010-0181-5

69. Antihyperglycemic, antihyperlipidemic, and antioxidant effects of Chaenomeles sinensis fruit extract in streptozotocin-induced diabetic rats

Author:: Sancheti, Sandesh; Sancheti, Shruti; Bafna, Mayur; Seo, Sung-Yum
Source:: European food research & technology 2010 v.231 no.3 pp. 415-421
ISSN:: 1438-2377
Subject:: Pseudocydonia sinensis; alanine transaminase; animal disease models; antioxidant activity; antioxidants; aspartate transaminase; blood glucose; blood serum; body weight; catalase; developing countries; diabetes mellitus; fasting; flavonoids; food research; free radicals; fruit extracts; fruits; glutathione; glycemic effect; glycogen; health services; hemoglobin; herbal medicines; high density lipoprotein cholesterol; hyperglycemia; kidneys; lipid metabolism; liver; low density lipoprotein cholesterol; oral administration; phenolic compounds; rats; streptozotocin; superoxide dismutase; triacylglycerols; urea nitrogen
Abstract:: ... The rising incidence of diabetes mellitus (DM) is alarming and becoming a major health problem worldwide, which is mainly associated with hyperglycemia, abnormal lipid, and antioxidant profiles. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care, including DM. Based on these facts, in this study, the antihyperglycemic, ...
DOI:: 10.1007/s00217-010-1291-x
: https://doi.org/10.1007/s00217-010-1291-x

70. Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse

Author:: Andersson, Ulrika; Rosén, Liza; Östman, Elin; Ström, Kristoffer; Wierup, Nils; Björck, Inger; Holm, Cecilia
Source:: Nutrition 2010 v.26 no.2 pp. 230-239
ISSN:: 0899-9007
Subject:: adipocytes; high fiber diet; energy intake; nutrition-genotype interaction; leptin; wheat; noninsulin-dependent diabetes mellitus; cholesteremic effect; gene expression; insulin resistance; animal disease models; body fat; blood lipids; blood serum; nutritional intervention; body weight; glycemic effect; triacylglycerols; mice; rye; insulin; weight loss; glucose tolerance; weight control; low fat diet; glycemic control; long term effects; cholesterol; whole grain foods
Abstract:: ... Objective: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. Methods: Mi ...
DOI:: 10.1016/j.nut.2009.06.007
PubMed:: 19647415
: https://doi.org/10.1016/j.nut.2009.06.007

71. Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin

Author:: Montagut, Gemma; Onnockx, Sheela; Vaqué, Montserrat; Bladé, Cinta; Blay, Mayte; Fernández-Larrea, Juan; Pujadas, Gerard; Salvadó, M. Josepa; Arola, Lluís; Pirson, Isabelle; Ardévol, Anna; Pinent, Montserrat
Source:: Journal of nutritional biochemistry 2010 v.21 no.6 pp. 476-481
ISSN:: 0955-2863
Subject:: grape seed extract; chemical constituents of plants; procyanidins; polymerization; structure-activity relationships; hypoglycemia; glycemic effect; glucose tolerance; rats; animal disease models; obesity; hyperglycemia; oxidative stress; streptozotocin; noninsulin-dependent diabetes mellitus; insulin resistance; nutrition-genotype interaction; hormonal regulation; hormone receptors; insulin; insulin secretion; biochemical pathways; signal transduction; glucose transporters; mitogen-activated protein kinase; protein phosphorylation
Abstract:: ... Procyanidins are bioactive flavonoid compounds from fruits and vegetables that possess insulinomimetic properties, decreasing hyperglycaemia in streptozotocin-diabetic rats and stimulating glucose uptake in insulin-sensitive cell lines. Here we show that the oligomeric structures of a grape-seed procyanidin extract (GSPE) interact and induce the autophosphorylation of the insulin receptor in order ...
DOI:: 10.1016/j.jnutbio.2009.02.003
PubMed:: 19443198
: https://doi.org/10.1016/j.jnutbio.2009.02.003

72. The antidiabetic plants Tecoma stans (L.) Juss. ex Kunth (Bignoniaceae) and Teucrium cubense Jacq (Lamiaceae) induce the incorporation of glucose in insulin-sensitive and insulin-resistant murine and human adipocytes

Author:: Alonso-Castro, Angel Josabad; Zapata-Bustos, Rocio; Romo-Yañez, José; Camarillo-Ledesma, Paul; Gómez-Sánchez, Maricela; Salazar-Olivo, Luis A.
Source:: Journal of ethnopharmacology 2010 v.127 no.1 pp. 1-6
ISSN:: 0378-8741
Subject:: Tecoma stans; mechanism of action; adipocytes; subcutaneous fat; human cell lines; glucose; medicinal properties; diabetes mellitus; glycemic effect; medicinal plants; plant extracts; mice; insulin; uptake mechanisms; Teucrium; animal disease models
Abstract:: ... Aim of the study: Tecoma stans (L.) Juss. ex Kunth (Bignoniaceae) and Teucrium cubense Jacq (Lamiaceae) are plants extensively used for the empirical treatment of diabetes mellitus, but their antidiabetic mechanisms remain to be clarified. In this study, the effect of aqueous extracts of Tecoma stans (TSE) and Teucrium cubense (TCE) on the glucose uptake in adipose cells was evaluated. Materials a ...
DOI:: 10.1016/j.jep.2009.09.060
PubMed:: 19818843
: https://doi.org/10.1016/j.jep.2009.09.060

73. A convenient synthesis of novel pyranosyl homo-C-nucleosides and their antidiabetic activities

Author:: Surendra Singh Bisht; Natasha Jaiswal; Anindra Sharma; Seerat Fatima; Rahul Sharma; Neha Rahuja; A.K. Srivastava; Vikas Bajpai; Brijesh Kumar; Rama P. Tripathi
Source:: Carbohydrate research 2011 v.346 no.10 pp. 1191-1201
ISSN:: 0008-6215
Subject:: alpha-glucosidase; animal disease models; diabetes mellitus; glucose-6-phosphatase; glycemic effect; glycogen; metformin; phosphorylase; pyridines; rats
Abstract:: ... A series of pyranosyl homo-C-nucleosides have been synthesized by reaction of butenonyl C-glycosides (5a–5j, and 8) and cyanoacetamide in presence of t-BuOK followed by further modifications. The reaction proceeds by Michael addition of cyanoacetamide to the butenonyl C-glycosides and subsequent dehydrative cyclization and oxidative aromatization to give glycosylmethyl pyridones (6a–6j, 7a–7j, 9, ...
DOI:: 10.1016/j.carres.2011.03.006
: https://doi.org/10.1016/j.carres.2011.03.006

74. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Author:: Nasim, Sekh Abdul; Dhir, Bhupinder; Kapoor, Rashmi; Fatima, Samar; Mahmooduzzafar; Mujib, Abdul
Source:: Pharmaceutical biology 2011 v.49 no.4 pp. 416-421
ISSN:: 1388-0209
Subject:: Allium sativum; Liliaceae; alanine transaminase; alkaline phosphatase; allicin; alloxan; animal disease models; aspartate transaminase; blood glucose; blood serum; cholesterol; cysteine; diabetes mellitus; environmental factors; garlic; glibenclamide; glycemic effect; high density lipoprotein; histopathology; leaf extracts; leaves; low density lipoprotein; medicinal properties; pancreas; rats; triacylglycerols; very low density lipoprotein
Abstract:: ... Context: Garlic, Allium sativum L. (Liliaceae), possesses high therapeutic and pharmacological properties. Hypoglycemic activity is attributed to alliin (S-allyl cysteine sulfoxide), the main active principle localized in garlic cloves. Objective: To compare the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex situ and in situ conditions. Materi ...
DOI:: 10.3109/13880209.2010.521163
: https://doi.org/10.3109/13880209.2010.521163

75. Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

Author:: Joel Deneau; Taufeeq Ahmed; Roger Blotsky; Krzysztof Bojanowski
Source:: International journal for vitamin and nutrition research 2011 v.81 no.1 pp. 34-42
ISSN:: 0300-9831
Subject:: DNA microarrays; H+/K+-exchanging ATPase; animal disease models; blood glucose; fibroblasts; fossils; gene expression; glycemic effect; glycohemoglobin; in vitro studies; metabolism; mice; mitochondria; noninsulin-dependent diabetes mellitus; ribosomal proteins; weight gain
Abstract:: ... Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes co ...
DOI:: 10.1024/0300-9831/a000048
: https://doi.org/10.1024/0300-9831/a000048

76. Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats

Author:: Imen Dahech; Karima Srih Belghith; Khaled Hamden; Abdelfattah Feki; Hafedh Belghith; Hafedh Mejdoub
Source:: International journal of biological macromolecules 2011 v.49 no.4 pp. 742-746
ISSN:: 0141-8130
Subject:: Bacillus licheniformis; adults; alanine transaminase; animal disease models; aspartate transaminase; aspartic acid; bacteria; bilirubin; catalase; creatinine; diabetic complications; diet; drinking water; glucose; glycemic effect; glycogen; heart; hyperglycemia; kidneys; levan; liver; oxidative stress; pancreas; rats; superoxide dismutase; thiobarbituric acid-reactive substances; toxicity; urea
Abstract:: ... This study aims to examine the effects of polysaccharide levan on oxidative stress and hyperglycemia in alloxan-induced diabetic rats. Levan, used in this study, was a microbial levan synthetisized by a non pathogenic bacteria recently isolated and identified as Bacillus licheniformis. Animals were allocated into four groups of six rats each: a control group (Control), diabetic group (Diab.), norm ...
DOI:: 10.1016/j.ijbiomac.2011.07.007
: https://doi.org/10.1016/j.ijbiomac.2011.07.007

77. Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats

Author:: Hossam M. Abdallah; Maha M. Salama; Enas H. Abd-elrahman; Shohda A. El-Maraghy
Source:: Phytochemistry letters 2011 v.4 no.3 pp. 337-341
ISSN:: 1874-3900
Subject:: Carya illinoinensis; aldehyde reductase; animal disease models; antioxidant activity; antioxidants; bark; diabetes mellitus; ethyl acetate; flavonols; glycemic effect; nuclear magnetic resonance spectroscopy; pecans; phenolic compounds; rats; streptozotocin; trees
Abstract:: ... The n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3′ sulfate (6) and caryatin-3′ methyl ether-7-O-β-d-glucoside (7) while five known phenolics (1–5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The ...
DOI:: 10.1016/j.phytol.2011.07.004
: https://doi.org/10.1016/j.phytol.2011.07.004

78. Antidiabetic effect of a newly identified component of Opuntia dillenii polysaccharides

Author:: L.Y. Zhao; Q.J. Lan; Z.C. Huang; L.J. Ouyang; F.H. Zeng
Source:: Phytomedicine 2011 v.18 no.8-9 pp. 661-668
ISSN:: 0944-7113
Subject:: Opuntia stricta var. dillenii; animal disease models; blood glucose; body weight; chromatography; diabetes mellitus; fasting; food intake; glucose-6-phosphatase; glutathione peroxidase; glycemic effect; glycogen; high density lipoprotein cholesterol; insulin; liver; malondialdehyde; mice; peroxidation; screening; streptozotocin; superoxide dismutase; triacylglycerols; ultrasonics; urea nitrogen
Abstract:: ... The aim of this study was to determine the most effective hypoglycemic component of polysaccharides from Opuntia dillenii Haw. by preliminary screening and to specifically study the antidiabetic effects of O. dillenii polysaccharide (ODP)-Ia in mice with streptozotocin (STZ)-induced diabetes. Three kinds of ODPs – ODP-Ia, ODP-Ib, and ODP-II′ – were isolated by using an ultrasonic extraction method ...
DOI:: 10.1016/j.phymed.2011.01.001
: https://doi.org/10.1016/j.phymed.2011.01.001

79. Antidiabetic potential of α-amylase inhibitor from the seeds of Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic mice

Author:: Gupta, Laxmi H.; Badole, Sachin L.; Bodhankar, Subhash L.; Sabharwal, Sushma G.
Source:: Pharmaceutical biology 2011 v.49 no.2 pp. 182-189
ISSN:: 1388-0209
Subject:: Macrotyloma uniflorum; alanine transaminase; alpha-amylase; animal disease models; aspartate transaminase; blood glucose; carboxymethylcellulose; cholesterol; diabetes mellitus; glycemic effect; histopathology; humans; inhibitory concentration 50; kidneys; liver; mice; nutritional intervention; obesity; pancreas; renal calculi; seeds; India
Abstract:: ... Context: Macrotyloma uniflorum (Lam.) Verdc. (Leguminosae) seeds, known as the poor man’s pulse crop in India, have been used as a food and also used in the traditional method for treatment of kidney stones, diabetes, obesity, etc. Objective: To investigate the antidiabetic effect of α-amylase inhibitor isolated from the seeds of Macrotyloma uniflorum seeds in streptozotocin-nicotinamide induced d ...
DOI:: 10.3109/13880209.2010.507633
: https://doi.org/10.3109/13880209.2010.507633

80. Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats

Author:: Biswas, Moulisha; Kar, Biswakanth; Bhattacharya, Sanjib; Kumar, R.B. Suresh; Ghosh, Ashoke Kumar; Haldar, Pallab Kanti
Source:: Pharmaceutical biology 2011 v.49 no.4 pp. 335-340
ISSN:: 1388-0209
Subject:: Terminalia arjuna; alanine transaminase; alkaline phosphatase; animal disease models; antioxidant activity; antioxidants; aspartate transaminase; blood glucose; blood serum; body weight; catalase; cholesterol; diabetes mellitus; drugs; fasting; glibenclamide; glutathione; glycemic effect; hyperglycemia; intraperitoneal injection; leaves; lipid peroxidation; methanol; protein content; rats; streptozotocin; trees
Abstract:: ... Context: Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes. Objective: To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats. Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection ...
DOI:: 10.3109/13880209.2010.516755
: https://doi.org/10.3109/13880209.2010.516755

81. Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats

Author:: Li, Huan-Ting; Wu, Xiao-Dong; Davey, Andrew K.; Wang, Jiping
Source:: Phytotherapy research 2011 v.25 no.2 pp. 189-194
ISSN:: 0951-418X
Subject:: pancreas; liver; adiponectin; NADP-glucose-6-phosphate dehydrogenase; hexokinase; neoplasms; necrosis; glycogen; blood glucose; glycemic effect; interleukin-6; enzyme-linked immunosorbent assay; tumor necrosis factor-alpha; insulin; flavonoids; diabetes; animal disease models; rats
Abstract:: ... The aim of the study was to investigate the effects of baicalin on blood glucose, insulin and cytokine levels. Rat diabetes was induced by intraperitoneal (i.p.) injection of nicotinamide and streptozotocin. Diabetic rats were dosed with i.p. baicalin or oral metformin daily for 8 days. Blood glucose, insulin and hepatic glycogen were determined using conventional methods. The activity of hepatic ...
DOI:: 10.1002/ptr.3238
PubMed:: 20632297
: https://doi.org/10.1002/ptr.3238

82. Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus

Author:: Xiaoming Chen; Jing Jin; Jia Tang; Zhongfu Wang; Junjun Wang; Liqin Jin; Jianxin Lu
Source:: Carbohydrate polymers 2011 v.83 no.2 pp. 749-754
ISSN:: 0144-8617
Subject:: Ophiopogon japonicus; animal disease models; anion exchange; blood glucose; cellulose; diabetes mellitus; ethanol; gel chromatography; glycemic effect; hypoglycemic agents; insulin; islets of Langerhans; medicinal plants; molecular weight; monosaccharides; rats; roots
Abstract:: ... In this research, a water-soluble polysaccharide (OJP1) extracted with hot water from the roots of Ophiopogon japonicus which is a traditional Chinese medicinal herb was precipitated with 95% ethanol and purified by DEAE-52 cellulose anion-exchange and Sephadex G-100 gel filtration chromatography. The high performance gel permeation chromatography (HPGPC) analysis showed that the average molecular ...
DOI:: 10.1016/j.carbpol.2010.08.050
: https://doi.org/10.1016/j.carbpol.2010.08.050

83. Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats

Author:: Kumar, Arvind; Lingadurai, Sutharson; Shrivastava, Tarani P.; Bhattacharya, Sanjib; Haldar, Pallab K.
Source:: Pharmaceutical biology 2011 v.49 no.6 pp. 577-582
ISSN:: 1388-0209
Subject:: Erythrina variegata; animal disease models; blood glucose; body weight; diabetes mellitus; drugs; fasting; glibenclamide; glycemic effect; hyperglycemia; intraperitoneal injection; leaves; lipid content; lipids; methanol; rats; streptozotocin; subtropics; trees; Australia; Eastern Africa; India
Abstract:: ... Context: Erythrina variegata Linn. (Fabaceae), commonly known as Tiger’s Claw, is a thorny deciduous tree grown in tropical and subtropical regions of Eastern Africa, Southern Asia, and Northern Australia. In India, its leaves are traditionally used for diabetes mellitus. Objective: To evaluate the hypoglycemic activity of methanol extract of E. variegata leaf (MEEV) in streptozotocin (STZ)-induce ...
DOI:: 10.3109/13880209.2010.529615
: https://doi.org/10.3109/13880209.2010.529615

84. Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction

Author:: Chongming Wu; Yan Li; Yan Chen; Xinyuan Lao; Linghui Sheng; Rongji Dai; Weiwei Meng; Yulin Deng
Source:: Phytomedicine 2011 v.18 no.4 pp. 292-297
ISSN:: 0944-7113
Subject:: isoflavones; diabetes mellitus; high performance liquid chromatography; polysaccharides; calcium channel blockers; animal disease models; blood serum; calcium; blood glucose; glycemic effect; fasting; potassium; insulin; rats; throat; Iris domestica; glycosides; glucose tolerance; potassium channels; leaf extracts; therapeutics
Abstract:: ... Belamcanda chinensis (Iridaceae) belongs to the family of iridaceae and its rhizoma has been widely used for the treatment of throat ailment. Here we report a new pharmacological activity of B. chinensis leaf extract (BCL), that is, the hypoglycemic effect in normal and STZ-induced diabetic rats. Animals either healthy or STZ-induced diabetic show significantly lowered fasting blood glucose levels ...
DOI:: 10.1016/j.phymed.2010.07.005
: https://doi.org/10.1016/j.phymed.2010.07.005

85. Influence of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, on glycoprotein components in streptozotocin-diabetic rats

Author:: Chandramohan Govindasamy; Khalid S. Al-Numair; Mohammed A. Alsaif; Kodukkur Pugalendi Viswanathan
Source:: Journal of Asian natural products research 2011 v.13 no.8 pp. 700-706
ISSN:: 1477-2213
Subject:: Casearia; animal disease models; antioxidants; body weight; enzymes; fucose; glibenclamide; glycemic effect; glycoproteins; hexosamines; kidneys; liver; long term effects; noninsulin-dependent diabetes mellitus; oral administration; protein metabolism; rats; roots; sialic acids; India
Abstract:: ... Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diabetic rats on antihyperglycemic, antioxidants, antihyperlipidemic, and protein met ...
DOI:: 10.1080/10286020.2011.585157
: https://doi.org/10.1080/10286020.2011.585157

86. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri

Author:: Okoli, C.O.; Obidike, I.C.; Ezike, A.C.; Akah, P.A.; Salawu, O.A.
Source:: Pharmaceutical biology 2011 v.49 no.3 pp. 248-255
ISSN:: 1388-0209
Subject:: Euphorbiaceae; Phyllanthus niruri; absorption; aerial parts; alloxan; alpha-amylase; alpha-glucosidase; animal disease models; blood glucose; body weight; diabetes mellitus; enzyme activity; glucose; glycation; glycemic control; glycemic effect; glycogen; hemoglobin; inhibitory concentration 50; liver; methanol; oral administration; rats
Abstract:: ... Context/objectives: The effects of methanol extract of aerial parts of Phyllanthus niruri L. (Euphorbiaceae), an antidiabetic herb, on glucose absorption and storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering and glycemic control in diabetes. Methods: The effect of chronic oral administration of the extract on glycemic control was evaluated in alloxan diabetic r ...
DOI:: 10.3109/13880209.2010.501456
: https://doi.org/10.3109/13880209.2010.501456

87. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles

Author:: Qiang Peng; Zhi-Rong Zhang; Tao Gong; Guo-Qiang Chen; Xun Sun
Source:: Biomaterials 2012 v.33 no.5 pp. 1583-1588
ISSN:: 0142-9612
Subject:: diabetes mellitus; evaporation; hydrophobicity; bioavailability; hydrophilicity; biodegradability; animal disease models; phospholipids; patient compliance; glycemic effect; subcutaneous injection; insulin; in vitro studies; rats; proteins; particle size; solvents; polymers; nanoparticles; zeta potential
Abstract:: ... The application of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) for sustained and controlled delivery of hydrophilic insulin was made possible by preparing insulin phospholipid complex loaded biodegradable PHBHHx nanoparticles (INS-PLC-NPs). The INS-PLC-NPs produced by a solvent evaporation method showed a spherical shape with a mean particle size, zeta potential and entrapment efficiency of ...
DOI:: 10.1016/j.biomaterials.2011.10.072
: https://doi.org/10.1016/j.biomaterials.2011.10.072

88. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

Author:: C.J.F. Muller; E. Joubert; D. de Beer; M. Sanderson; C.J. Malherbe; S.J. Fey; J. Louw
Source:: Phytomedicine 2012 v.20 no.1 pp. 32-39
ISSN:: 0944-7113
Subject:: Aspalathus linearis; alpha-glucosidase; animal disease models; blood glucose; body weight; diabetes mellitus; dose response; glucose; glucose tolerance tests; glycemic effect; herbal tea; metformin; monitoring; plant extracts; polyphenols; rats; rutin; screening
Abstract:: ... Rooibos, an endemic South African plant, known for its use as herbal tea, has potential as an antidiabetic herbal product, following recent demonstration of the glucose lowering effect of its major flavonoid, the dihydrochalcone C-glucoside aspalathin. The purpose of this study was to confirm antidiabetic activity for rooibos extract high in aspalathin content. An extract (SB1) was selected after ...
DOI:: 10.1016/j.phymed.2012.09.010
: https://doi.org/10.1016/j.phymed.2012.09.010

89. Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats

Author:: Pei-Bo Li; Wan-Ling Lin; Yong-Gang Wang; Wei Peng; Xue-Ying Cai; Wei-Wei Su
Source:: International journal of biological macromolecules 2012 v.51 no.5 pp. 749-755
ISSN:: 0141-8130
Subject:: animal disease models; blood glucose; body weight; enzyme activity; excretion; fasting; glucagon; glucagon-like peptide 1; glucose tolerance; glycemic effect; glycogen; high fat diet; histopathology; kidneys; liver; noninsulin-dependent diabetes mellitus; oligosaccharides; oral administration; pancreas; rats; skeletal muscle; streptozotocin
Abstract:: ... The aim of the present study is to investigate the antidiabetic properties of oligosaccharides of Ophiopogonis japonicus (OOJ) in experimental type 2 diabetic rats. OOJ was administered orally in doses of 225 and 450mg/kg body weight to high-fat diet and low-dose streptozotocin (STZ)-induced type 2 diabetic rats for 3 weeks. The results showed that OOJ treatment could increase body weight, decreas ...
DOI:: 10.1016/j.ijbiomac.2012.07.007
: https://doi.org/10.1016/j.ijbiomac.2012.07.007

90. Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase

Author:: Natasha Jaiswal; Vikram Bhatia; Swayam Prakash Srivastava; Arvind Kumar Srivastava; Akhilesh Kumar Tamrakar
Source:: Natural product research 2012 v.26 no.24 pp. 2363-2367
ISSN:: 1478-6427
Subject:: Eclipta prostrata; aldehyde reductase; alpha-glucosidase; animal disease models; blood glucose; blood serum; creatinine; diabetic nephropathy; eye lens; glycemic effect; hyperglycemia; inhibitory concentration 50; insulin; oral administration; rats; urea; uric acid
Abstract:: ... The antidiabetic effect of the ethanolic extract of Eclipta alba (EEA) on hyperglycaemia and diabetic nephropathy was investigated in streptozotocin-induced diabetic rats. Single-dose treatment of EEA to streptozotocin-induced diabetic rats lowered the blood glucose level by 17.6% (p < 0.05) at 250 mg kg⁻¹ dose after 5 h post oral administration. Treatment of animals after 10 weeks of STZ-treatmen ...
DOI:: 10.1080/14786419.2012.662648
: https://doi.org/10.1080/14786419.2012.662648

91. Antihyperglycemic Effect of Syringaldehyde in Streptozotocin-Induced Diabetic Rats

Author:: Huang Chia-Hsin; Chen Mei-Fen; Chung Hsien-Hui; Cheng Juei-Tang
Source:: Journal of natural products 2012 v.75 no.8 pp. 1465-1468
ISSN:: 1520-6025
Subject:: Hibiscus; animal disease models; blood glucose; diabetes mellitus; dose response; glucose; glycemic effect; insulin resistance; intravenous injection; rats; stems
Abstract:: ... The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the in ...
DOI:: 10.1021/np3003723
: https://doi.org/10.1021/np3003723

92. Antihyperglycemic effect of esculetin modulated carbohydrate metabolic enzymes activities in streptozotocin induced diabetic rats

Author:: Dhamodaran Prabakaran; Natarajan Ashokkumar
Source:: Journal of functional foods 2012 v.4 no.4 pp. 776-783
ISSN:: 1756-4646
Subject:: food intake; carbohydrate metabolism; rats; NADP-glucose-6-phosphate dehydrogenase; public health; Matricaria chamomilla; fructose-bisphosphatase; blood glucose; glycemic effect; hemoglobin; streptozotocin; noninsulin-dependent diabetes mellitus; insulin; oral administration; glucokinase; glucose-6-phosphatase; weight loss; animal disease models; glucose tolerance tests
Abstract:: ... Type 2 diabetes mellitus (T2DM) being a worldwide challenge to public health. The aim of this study was to examine the effect of esculetin, a major compound present in the herbal plant of Matricaria chamomilla L., on the key enzymes of carbohydrate metabolism in streptozotocin (STZ) induced diabetic rats. At first, the rats were induced intraperitonial injection of STZ (40mg/kgbw) to attain diabet ...
DOI:: 10.1016/j.jff.2012.05.005
: https://doi.org/10.1016/j.jff.2012.05.005

93. Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components

Author:: Ramalingam Sundaram; Rajendran Naresh; Palanivelu Shanthi; Panchanatham Sachdanandam
Source:: Phytomedicine 2012 v.19 no.3-4 pp. 211-216
ISSN:: 0944-7113
Subject:: Vitex negundo; animal disease models; blood glucose; diabetes mellitus; fucose; glibenclamide; glucosides; glycemic effect; glycoproteins; hexosamines; hyperglycemia; hypoglycemic agents; insulin; iridoid glycosides; leaves; metabolism; oral administration; rats; sialic acids
Abstract:: ... The aim of present study was to isolate an iridoid glucoside from the leaves of Vitex negundo and evaluates its effects on dearrangement in plasma and tissues glycoprotein components in streptozotocin-induced diabetic rats. The levels of blood glucose, plasma and tissues glycoproteins such as hexose, hexosamine, fucose and sialic acid were significantly increased whereas plasma insulin levels were ...
DOI:: 10.1016/j.phymed.2011.10.006
: https://doi.org/10.1016/j.phymed.2011.10.006

94. Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats

Author:: Rahman Md. Hafizur; Nurul Kabir; Sidra Chishti
Source:: British journal of nutrition 2012 v.108 no.9 pp. 1586-1595
ISSN:: 1475-2662
Subject:: Asparagus officinalis; animal disease models; antioxidant activity; antioxidants; blood glucose; blood serum; fasting; fluorescence; glibenclamide; glycemic effect; hypoglycemic agents; in vitro studies; insulin; insulin secretion; islets of Langerhans; noninsulin-dependent diabetes mellitus; pups; rats; seeds; staining; streptozotocin
Abstract:: ... The aim of the present study was to evaluate the anti-diabetic mechanism of Asparagus officinalis, a dietary agent used for the management of diabetes. Streptozotocin (90 mg/kg) was injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes. After confirmation of diabetes on the 13th week, diabetic rats were treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg ...
DOI:: 10.1017/S0007114511007148
PubMed:: 22221560
: https://doi.org/10.1017/S0007114511007148

95. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats

Author:: Nafiu Bidemi Abdulrazaq; Maung Maung Cho; Ni Ni Win; Rahela Zaman; Mohammad Tariqur Rahman
Source:: British journal of nutrition 2012 v.108 no.7 pp. 1194-1201
ISSN:: 1475-2662
Subject:: Zingiber officinale; animal disease models; blood glucose; body weight; diabetes mellitus; dose response; ginger; glucokinase; glycemic effect; glycogen; glycolysis; kidneys; liver; oral administration; phosphofructokinases; pyruvate kinase; rats; skeletal muscle; streptozotocin
Abstract:: ... Zingiber officinale (ZO), commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to st ...
DOI:: 10.1017/S0007114511006635
PubMed:: 22152092
: https://doi.org/10.1017/S0007114511006635

96. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats

Author:: Wenzhu Zhao; Yongguang Yin; Zhipeng Yu; Jingbo Liu; Feng Chen
Source:: International journal of biological macromolecules 2012 v.50 no.4 pp. 1133-1137
ISSN:: 0141-8130
Subject:: animal disease models; antidepressants; blood glucose; blood lipids; body weight; cholesterol; diabetes mellitus; dose response; ethanol; glucose tolerance tests; glycemic effect; herbal medicines; hyperglycemia; polysaccharides; rats; streptozotocin; styles (flowers); triacylglycerols
Abstract:: ... Corn silk is well known and frequently used in traditional Chinese herbal medicines. Polysaccharides of corn silk (POCS), which were extracted by distilled water and precipitated by 80% ethanol solution, were evaluated for its anti-diabetic effect on streptozotocin (STZ)-induced diabetic rats. The results demonstrated that daily treatment with 100–500mg/kg body weight of POCS on the diabetic rats ...
DOI:: 10.1016/j.ijbiomac.2012.02.004
: https://doi.org/10.1016/j.ijbiomac.2012.02.004

97. Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes

Author:: Vânia O. Gutierres; Clara M. Pinheiro; Renata P. Assis; Regina C. Vendramini; Maria T. Pepato; Iguatemy L. Brunetti
Source:: British journal of nutrition 2012 v.108 no.3 pp. 440-448
ISSN:: 1475-2662
Subject:: alanine; animal disease models; aspartic acid; biomarkers; blood glucose; blood serum; body weight; cages; curcumin; diabetes mellitus; dose response; glucose; glycemic effect; glycogen; high density lipoprotein cholesterol; insulin; proteinuria; rats; subcutaneous injection; tissues; transaminases; urea; urine; yogurt
Abstract:: ... We investigated the effects of prolonged treatment of diabetic rats with curcumin-supplemented yoghurt on the physiological and biochemical changes associated with diabetes mellitus. An established metabolic cage model was used to assess these changes in three groups of streptozotocin-diabetic rats which had been administered, by gavage, curcumin blended into yoghurt in the doses of 30, 60 and 90 ...
DOI:: 10.1017/S0007114511005769
PubMed:: 22067670
: https://doi.org/10.1017/S0007114511005769

98. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography–mass spectrometry

Author:: Jun Niu; Zifeng Pi; Hao Yue; Yang Wang; Qing Yu; Shuying Liu
Source:: Journal of chromatography 2012 v.907 no. pp. 7-12
ISSN:: 1570-0232
Subject:: DNA; Panax; animal disease models; biomarkers; energy metabolism; excretion; fatty acid metabolism; glycemic effect; hormone metabolism; liquid chromatography; mass spectrometry; mechanism of action; metabolomics; noninsulin-dependent diabetes mellitus; organic acids and salts; polysaccharides; principal component analysis; rats; serotonin; steroid hormones; steroid metabolism; tryptophan
Abstract:: ... Ginseng polysaccharide is known to have anti-hyperglycemic and anti-hyperlipidemic effects in vivo and its precise mechanism of action is not clear. A urinary metabolomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of water-soluble ginseng polysaccharide (WGP) on type 2 diabetes in rats. Principal component analysis (P ...
DOI:: 10.1016/j.jchromb.2012.08.012
: https://doi.org/10.1016/j.jchromb.2012.08.012

99. Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

Author:: Ramalingam Sundaram; Rajendran Naresh; Palanivelu Shanthi; Panchanatham Sachdanandam
Source:: Phytomedicine 2012 v.19 no.8-9 pp. 725-729
ISSN:: 0944-7113
Subject:: animal disease models; blood glucose; body weight changes; diabetes mellitus; glibenclamide; glucose; glucose-6-phosphatase; glycemic effect; glycolysis; glycosylation; hemoglobin; hexokinase; insulin; oral administration; rats; streptozotocin
Abstract:: ... The aim of the present investigation was to evaluate the anti-diabetic activity of 20-OH-ecdysone on glucose metabolic key enzymes in control and streptozotocin induced diabetic rats. On oral administration of 20-OH-ecdysone at a dose of 5mg/kg body weight per day to diabetic rats for 30 days resulted in a significant decrease in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and an ...
DOI:: 10.1016/j.phymed.2012.02.019
: https://doi.org/10.1016/j.phymed.2012.02.019

100. Evaluation of hypoglycemic activity of the leaves of Malva parviflora in streptozotocin-induced diabetic rats

Author:: Rosa Martha Perez Gutierrez
Source:: Food & function 2012 v.3 no.4 pp. 420-427
ISSN:: 2042-650X
Subject:: Malva parviflora; advanced glycation end products; animal disease models; blood glucose; catalase; chloroform; cholesterol; diabetes; enzyme activity; glucokinase; glucose; glucose-6-phosphatase; glutathione peroxidase; glutathione-disulfide reductase; glycation; glycemic effect; glycogen; glycosylation; hemoglobin; hexane; hexokinase; insulin; insulin resistance; leaves; lipid peroxidation; liver; liver function; medicinal properties; methanol; muscles; oxidative stress; pathogenesis; rats; streptozotocin; superoxide dismutase; thiobarbituric acid-reactive substances; triacylglycerols; Mexico
Abstract:: ... Malva parviflora (MP), known in Mexico by the name of “quesitos” or “malva”, is popular due to its culinary and medicinal properties. Diabetic rats were treated with the hexane, chloroform and methanol extracts of the M. parviflora leaves for 28 days and a set of biochemical parameters were studied including: glucose level, total cholesterol, triglycerides, lipid peroxidation, liver and muscle gly ...
DOI:: 10.1039/c2fo10153j
: https://doi.org/10.1039/c2fo10153j

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1. Antihyperglycemic Activity of Helicteres isora Roots in Alloxan-Induced Diabetic Rats

2. Antioxidant activity of Indian herbal drugs in rats with alloxan-induced diabetes

3. Amelioration of altered antioxidant status and membrane linked functions by vanadium andTrigonella in alloxan diabetic rat brains

4. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats

5. Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats

6. Antidiabetic activity of some Indian medicinal plants

7. Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes

8. Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia platycarpa

9. Dietary caloric restriction modifies inflammatory responses in the livers of streptozotocin-induced diabetic rats

10. Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models

11. A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats

12. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats

13. Antidiabetic properties of selected Mexican copalchis of the Rubiaceae family

14. Antihyperglycemic Effects of Platycodon grandiflorum (Jacq.) A. DC. Extract on Streptozotocin-induced Diabetic Mice

15. Antihyperglycemic Property of Tragia cannabina in Streptozotocin-Induced Diabetic Rats

16. Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats

17. Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats

18. Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats

19. Changes in Glycoprotein Components in Streptozotocin - Nicotinamide Induced Type 2 Diabetes: Influence of Tetrahydrocurcumin from Curcuma longa

20. Constituents of Ocimum sanctum with Antistress Activity

21. D-chiro-inositol found in momordica charantia fruit extract plays a role in reducing blood glucose in streptozotocin-diabetic rats

22. Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice

23. Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro

24. Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats

25. Ethanol extract of Gymnema montanum leaves reduces glycoprotein components in experimental diabetes

26. Hypoglycaemic constituents of Stachytarpheta cayennensis leaf

27. Indian herbs result in hypoglycemic responses in streptozotocin-induced diabetic rats

28. Monoglycerides and fatty acids from Ibervillea sonorae root: isolation and hypoglycemic activity

29. The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice

30. Animal models to test drugs with potential antidiabetic activity

31. Anti-diabetic Effects of Cesium Aqua (N,N′-ethylene(salicylideneiminato)-5-sulfonato) Oxovanadium (IV) Dihydrate in Streptozotocin-induced Diabetic Rats

32. Antidiabetic and Antioxidant Effects of Polyphenols in Brown Alga Ecklonia stolonifera in Genetically Diabetic KK-Ay Mice

33. Antihyperglycemic Effect of Stem Bark Powder from Paper Mulberry (Broussonetia kazinoki Sieb.) in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats

34. Antihyperglycemic profile of Trichosanthes dioica seeds in experimental models

35. Comparison between ethanolic and aqueous extracts from Chinese juniper berries for hypoglycaemic and hypolipidemic effects in alloxan-induced diabetic rats

36. Effect of Andrographolide and Ethanol Extract of Andrographis paniculata on Liver Glycolytic, Gluconeogenic, and Lipogenic Enzymes in a Type 2 Diabetic Rat Model

37. Effect of Lepidium sativum L. on renal glucose reabsorption and urinary TGF-β1 levels in diabetic rats

38. Effect of Picrorrhiza Rhizoma Extracts on Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats

39. Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction

40. Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

41. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates

42. Hypoglycemic and Antihyperglycemic Activity of Nymphaea stellata Flowers in Normal and Alloxan Diabetic Rats

43. Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats

44. Insulinomimetic Effect of Kaempferol 3-Neohesperidoside on the Rat Soleus Muscle

45. Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice

46. A mixture of Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces body weight gain, visceral fat accumulation, and total cholesterol and insulin increases in male Wistar fatty rats

47. Anti-diabetic activity of Emblica officinalis in animal models

48. Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice

49. Anti-diabetic properties of three common Bidens pilosa variants in Taiwan

50. Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract

51. Antidiabetic activity of extracts and fraction of Zizyphus mauritiana

52. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

53. Antihyperglycemic and hypoglycemic activities of Phyllanthus debilis aqueous plant extract in mice

54. Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera

55. Biochemical evaluation of antihyperglycemic and antioxidant nature of Psidium guajava leaves extract in streptozotocin-induced experimental diabetes in rats

56. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers

57. Evaluation of antidiabetic activity of the seeds of Swietenia macrophylla in diabetic rats

58. Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species

59. Hypoglycemic Polysaccharides from the Tuberous Root of Liriope spicata

60. Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae

61. Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor, Coprinus comatus, and Lenzites betulina isolates in streptozotocin-induced diabetic rats [Erratum: 2009 May, v. 47, no. 5, p. 471-472.]

62. Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse

63. Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects

64. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats

65. Taurine supplementation modulates glucose homeostasis and islet function

66. Antidiabetic and antihyperlipidemic activity of ethyl acetate:Isopropanol (1:1) fraction of Vernonia anthelmintica seeds in Streptozotocin induced diabetic rats

67. Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice

68. Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats

69. Antihyperglycemic, antihyperlipidemic, and antioxidant effects of Chaenomeles sinensis fruit extract in streptozotocin-induced diabetic rats

70. Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse