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- Author:
- Takahiro Tsuji; Kazumi Furuhara; Maria Gerasimenko; Anna Shabalova; Stanislav M Cherepanov; Kana Minami; Haruhiro Higashida; Chiharu Tsuji
- Source:
- Nutrients 2022 v.14 no.4 pp. -
- ISSN:
- 2072-6643
- Subject:
- amygdala; animal models; autism; carnosine; cerebrospinal fluid; human population; hypothalamus; nutritional intervention; oxytocin; social behavior
- Abstract:
- ... The outcomes of supplementation with L-carnosine have been investigated in clinical trials in children with autism spectrum disorder (ASD). However, reports on the effects of L-carnosine in humans have been inconsistent, and the efficacy of L-carnosine supplementation for improving ASD symptoms has yet to be investigated in animal studies. Here, we examined the effects of oral supplementation with ...
- DOI:
- 10.3390/nu14040803
- https://doi.org/10.3390/nu14040803
- Author:
- Qi Huang; Jiajia Qi; Ziru Gao; Lili Li; Ning Wang; Saiwang Seto; Min Yao; Qianqian Zhang; Lei Wang; Ruonan Tong; Yuyang Chen; Xiaoya Chen; Jincai Hou
- Source:
- Journal of ethnopharmacology 2022 v.283 pp. 114705
- ISSN:
- 0378-8741
- Subject:
- animal models; brain; calcium; cell viability; cerebrospinal fluid; danshensu; diodes; drugs; fluorescent antibody technique; high performance liquid chromatography; infarction; mass spectrometry; microvessels; protective effect; reactive oxygen species; stroke; survival rate; therapeutics; traditional medicine; ultra-performance liquid chromatography; wnt proteins; China
- Abstract:
- ... Dan-Deng-Tong-Nao Capsules (DDTNC) is a Chinese patent medicine and has been used in treating cerebral ischemic stroke (IS) for a long time in China, protection of brain microvascular endothelial cells (BMECs) is the main treatment strategy. But the holistic chemical information and potential bioactive components of DDTNC on protecting BMECs and its underlying mechanism is still unclear.To identif ...
- DOI:
- 10.1016/j.jep.2021.114705
- https://doi.org/10.1016/j.jep.2021.114705
- Author:
- Ruimin Tian; Xianfeng Liu; Lijia Jing; Lu yang; Na Xie; Ya Hou; Honglin Tao; Yiwen Tao; Jiasi Wu; Xianli Meng
- Source:
- Journal of ethnopharmacology 2022 v.292 pp. 115196
- ISSN:
- 0378-8741
- Subject:
- Alzheimer disease; animal models; autophagy; blood glucose; blood lipids; body weight; caspase-1; cerebrospinal fluid; cognition; cognitive disorders; encephalopathy; eosin; fluorescence; fluorescent antibody technique; glucose; glutathione; high fat diet; high performance liquid chromatography; hippocampus; histopathology; inflammasomes; insulin resistance; lipid metabolism; lipids; malondialdehyde; memory; metformin; neurons; neuroprotective effect; noninsulin-dependent diabetes mellitus; oxidative stress; protein synthesis; streptozotocin; superoxide dismutase; traditional medicine; transmission electron microscopy
- Abstract:
- ... Huang-Lian-Jie-Du decoction (HLJDD) is a traditional Chinese formula that is efficacious in treating diabetes mellitus, Alzheimer's disease, and diabetic encephalopathy; the underlying mechanisms of HLJDD in diabetes-associated cognitive dysfunction remain unclear. This study investigated the neuroprotective effects of HLJDD on cognitive function, and the possible underlying mechanisms in type 2 d ...
- DOI:
- 10.1016/j.jep.2022.115196
- https://doi.org/10.1016/j.jep.2022.115196
- Author:
- Xin Wu; Ashok K. Shetty; Doodipala Samba Reddy
- Source:
- Life sciences 2021 v.285 pp. 119971
- ISSN:
- 0024-3205
- Subject:
- aggression; animal models; cerebrospinal fluid; cognition; deet; emotions; epilepsy; etiology; hippocampus; memory; neurons; neurotoxicity; organophosphorus compounds; permethrin; prototypes; social behavior; thalamus
- Abstract:
- ... Gulf War Illness (GWI) is a multi-symptom disease with debilitating cognitive and emotional impairments in veterans. GWI, like epilepsy, is caused by chemical neurotoxicity and manifests from disturbances in neuronal excitability. However, the mechanisms underlying such devastating neurological and psychiatric symptoms remain unclear. Here we investigated the long-term changes in neural behavior a ...
- DOI:
- 10.1016/j.lfs.2021.119971
- https://doi.org/10.1016/j.lfs.2021.119971
- Author:
- Jing Wu; Yu-Chuan Dai; Xing-Yu Lan; Hong-Feng Zhang; Shu-Zhen Bai; Ying Hu; Song-Ping Han; Ji-Sheng Han; Rong Zhang
- Source:
- Peptides 2021 v.137 pp. 170493
- ISSN:
- 0196-9781
- Subject:
- adolescence; animal models; arginine vasopressin; autism; cells; cerebrospinal fluid; etiology; infants; pathogenesis; rats; social behavior; stereotyped behavior; subcutaneous injection; valproic acid
- Abstract:
- ... Studies have shown that arginine-vasopressin (AVP) is an important neuropeptide regulating social behaviors. The present work aimed to detect changes in the AVP numbers and level in a valproic acid (VPA)-induced rat model of autism and the underlying mechanism of its pathogenesis. Our results indicated that infants exposed to VPA showed obviously impaired communication and repetitive behaviors wit ...
- DOI:
- 10.1016/j.peptides.2021.170493
- https://doi.org/10.1016/j.peptides.2021.170493
- Author:
- Katia Martínez-González; Leonor Serrano-Cuevas; Eduardo Almeida-Gutiérrez; Salvador Flores-Chavez; Juan Manuel Mejía-Aranguré; Paola Garcia-delaTorre
- Source:
- Nutrition 2021 v.90 pp. 111248
- ISSN:
- 0899-9007
- Subject:
- Alzheimer disease; animal models; arginine; brain; cerebrospinal fluid; citrulline; cognitive disorders; females; males; memory disorders; nitric oxide; nutrition; oral administration; spatial memory; ultra-performance liquid chromatography
- Abstract:
- ... Alzheimer's disease (AD) correlates with the dysfunction of metabolic pathways that translates into neurological symptoms. An arginine deficiency, a precursor of nitric oxide (NO), has been reported for patients with AD. We aimed to evaluate the effect of citrulline oral supplementation on cognitive decline in an AD murine model.Three-month citrulline or water supplementation was blindly given to ...
- DOI:
- 10.1016/j.nut.2021.111248
- https://doi.org/10.1016/j.nut.2021.111248
- Author:
- Meishen Ren; Hong Mei; Jiaojiao Zhou; Ming Zhou; Heyou Han; Ling Zhao
- Source:
- Archives of virology 2021 v.166 no.4 pp. 1083-1092
- ISSN:
- 0304-8608
- Subject:
- RNA; Rabies lyssavirus; animal models; cerebrospinal fluid; early diagnosis; genomics; humans; liquids; mortality; public health; rabies; virology
- Abstract:
- ... Rabies, which is caused by rabies virus (RABV), poses an ever-present threat to public health in most countries of the world. Once clinical signs appear, the mortality of rabies approaches 100%. To date, no effective method for early rabies diagnosis has been developed. In this study, an RPA-CRISPR nucleic-acid-based assay was developed for early rabies diagnosis by detecting viral RNA shedding in ...
- DOI:
- 10.1007/s00705-021-04970-x
- https://doi.org/10.1007/s00705-021-04970-x
- Author:
- Cristina Durán Fernández-Feijóo; Javier Rodríguez-Fanjul; Miriam Lopez-Abat; Stephanie Hadley; Mónica Cavia-Saiz; Pilar Muñiz; Juan Arnaez; José Ramón Fernández-Lorenzo; Marta Camprubí Camprubí
- Source:
- Antioxidants 2021 v.10 no.10 pp. -
- ISSN:
- 2076-3921
- Subject:
- allopurinol; animal models; antioxidant activity; biomarkers; brain; brain damage; cerebrospinal fluid; encephalopathy; hypothermia; lipid peroxidation; morbidity; mortality; neuroprotective effect; oxidation; oxidative stress; pathophysiology; postpartum period; rats; therapeutics
- Abstract:
- ... Hypoxic ischemic encephalopathy (HIE) is one of the main causes of morbidity and mortality during the neonatal period, despite treatment with hypothermia. There is evidence that oxidative damage plays an important role in the pathophysiology of hypoxic-ischemic (HI) brain injury. Our aim was to investigate whether postnatal allopurinol administration in combination with hypothermia would reduce ox ...
- DOI:
- 10.3390/antiox10101523
- https://doi.org/10.3390/antiox10101523
- Author:
- Mahmoud Agami; Rasha A. Shaalan; Saied F. Belal; Marwa A.A. Ragab
- Source:
- Analytical and bioanalytical chemistry 2021 v.413 no.20 pp. 5181-5191
- ISSN:
- 1618-2642
- Subject:
- ammonium; analytical chemistry; animal models; brain; cerebrospinal fluid; chitosan; cholinesterase inhibitors; electrospray ionization mass spectrometry; formates; methanol; nose; pH; pharmacokinetics; quality control; quantitative analysis; rats
- Abstract:
- ... Validated LC-MS method for the direct quantitative analysis of galantamine (acetylcholinesterase inhibitor) was developed in rat cerebrospinal fluid and brain homogenate besides rat plasma, utilizing structurally close nalbuphine as an internal standard. After a simple protein precipitation step, samples are separated on 2-μm C18 column kept at 40 °C, using isocratic flow of 80% methanol in pH 9.5 ...
- DOI:
- 10.1007/s00216-021-03487-1
- https://doi.org/10.1007/s00216-021-03487-1
- Author:
- Lijun Zhang; Hong Xiao; Xing Yu; Yongbing Deng
- Source:
- Archives of biochemistry and biophysics 2020 v.682 pp. 108302
- ISSN:
- 0003-9861
- Subject:
- Western blotting; animal models; blood serum; brain damage; cell viability; cerebrospinal fluid; cortex; divalent metals; ferritin; hepcidin; hippocampus; iron; iron absorption; minocycline; neurons; staining; tetracycline; transferrin receptors
- Abstract:
- ... There is currently no effective treatment for neurological impairment caused by traumatic brain injury (TBI). It has been reported that excessive iron production in the brain may be a key factor in neurological impairment. In the present study, we investigated the effects of minocycline, a semi-synthetic tetracycline antibiotic, against TBI-induced neurological impairment and explored its underlyi ...
- DOI:
- 10.1016/j.abb.2020.108302
- https://doi.org/10.1016/j.abb.2020.108302
- Author:
- Birsen Elibol; Merve Beker; Sule Terzioglu-Usak; Tugce Dalli; Ulkan Kilic
- Source:
- Phytomedicine 2020 v.79 pp. 153324
- ISSN:
- 0944-7113
- Subject:
- Alzheimer disease; Nigella sativa; acetylcholinesterase; active ingredients; adults; amyloid; animal models; cannulas; cell viability; cerebrospinal fluid; females; hippocampus; histopathology; memory; microRNA; neurons; neuropathology; phenotype; quantitative polymerase chain reaction; rats; therapeutics; thymoquinone
- Abstract:
- ... Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, anti-oxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer`s disease (AD) pathology rather than current symptomatic reliefs.In the present study, we examined the molecular healing effects of TQ in amyloid beta 1–42 (Aβ₁–₄₂) peptide-infused AD rat hi ...
- DOI:
- 10.1016/j.phymed.2020.153324
- https://doi.org/10.1016/j.phymed.2020.153324
- Author:
- Karen M. Vernau; Eduard Struys; Anna Letko; Kevin D. Woolard; Miriam Aguilar; Emily A. Brown; Derek D. Cissell; Peter J. Dickinson; G. Diane Shelton; Michael R. Broome; K. Michael Gibson; Phillip L. Pearl; Florian König; Thomas J. Van Winkle; Dennis O’Brien; B. Roos; Kaspar Matiasek; Vidhya Jagannathan; Cord Drögemüller; Tamer A. Mansour; C. Titus Brown; Danika L. Bannasch
- Source:
- Genes 2020 v.11 no.9 pp. -
- ISSN:
- 2073-4425
- Subject:
- aldehyde dehydrogenase; animal models; atrophy; biochemical pathways; blood serum; brain; cerebrospinal fluid; gamma-aminobutyric acid; genes; genetic analysis; genome-wide association study; homozygosity; human diseases; humans; magnetic resonance imaging; necropsy; neurotransmitters; phenotype; puppies; screening; seizures; sequence analysis; succinic acid; therapeutics; urine
- Abstract:
- ... Dogs provide highly valuable models of human disease due to the similarity in phenotype presentation and the ease of genetic analysis. Seven Saluki puppies were investigated for neurological abnormalities including seizures and altered behavior. Magnetic resonance imaging showed a diffuse, marked reduction in cerebral cortical thickness, and symmetrical T2 hyperintensity in specific brain regions. ...
- DOI:
- 10.3390/genes11091033
- https://doi.org/10.3390/genes11091033
- Author:
- Elisabetta Chiaradia; Ingrid Miller
- Source:
- Journal of proteomics 2020 v.225 pp. 103880
- ISSN:
- 1874-3919
- Subject:
- animal models; biomarkers; blood serum; cerebrospinal fluid; early diagnosis; economic impact; health status; hippotherapy; horse diseases; horses; human diseases; human health; industry; meat production; medicine; prognosis; proteins; proteome; proteomics; saliva; signs and symptoms (animals and humans); sports; synovial fluid; tissues; urine; veterinary medicine
- Abstract:
- ... Equine medicine represents a relevant field of veterinary science and the horse industry generates a significant economic impact. Horses can be involved in different sport disciplines, meat production, work and recreational purposes. Horses are also important for human health as they can be used as animal models for studying human diseases and in equine-assisted therapy. This review summarizes the ...
- DOI:
- 10.1016/j.jprot.2020.103880
- https://doi.org/10.1016/j.jprot.2020.103880
- Author:
- Arjun L. Khandare; Kalakumar B; Vakdevi Validandi; Qadri SSYH; N. Harishankar; Surya S. Singh; Venkaiah Kodali
- Source:
- Research in veterinary science 2020 v.132 pp. 49-53
- ISSN:
- 0034-5288
- Subject:
- Capra hircus; Lathyrus sativus; animal models; blood; cerebrospinal fluid; clinical examination; flour; goats; lathyrism; muscles; nerve tissue; nitrites; research; toxins; urine; veterinary medicine
- Abstract:
- ... The present study was undertaken to develop an animal model to study neurolathyrism. For this purpose 24 goat (Capra hircus) kids (new born, 15 days old) were divided into four groups. Group I Control, Group II Low toxin (0.17 g% β-ODAP containing grass pea), Group III high toxin (0.96 g% β-ODAP containing grass pea) and Group IV high toxin (0.96 g% β-ODAP containing grass pea flour (powder) forti ...
- DOI:
- 10.1016/j.rvsc.2020.05.019
- https://doi.org/10.1016/j.rvsc.2020.05.019
- Author:
- Behem Christoph R.; Friedheim Till; Wipper Sabine H.; Pinnschmidt Hans O.; Graessler Michael F.; Gaeth Catharina; Holthusen Hannes; Rapp Adina; Suntrop Timo; Haunschild Josephina; Etz Christian D.; Trepte Constantin J. C.
- Source:
- Journal of visualized experiments 2020 no.166 pp. e62047
- ISSN:
- 1940-087X
- Subject:
- animal injuries; animal models; aorta; cerebrospinal fluid; drainage; fluorescence; hemodynamics; histopathology; ischemia; microparticles; oxygen; patients; spinal cord; swine
- Abstract:
- ... Spinal cord injury is a devastating complication of aortic repair. Despite developments for the prevention and treatment of spinal cord injury, its incidence is still considerably high and therefore, influences patient outcome. Microcirculation plays a key role in tissue perfusion and oxygen supply and is often dissociated from macrohemodynamics. Thus, direct evaluation of spinal cord microcircula ...
- DOI:
- 10.3791/62047
- https://doi.org/10.3791/62047
- Author:
- Tomasz Misztal; Marian R. Czauderna; Patrycja Młotkowska; Anna Misztal; Elżbieta Marciniak
- Source:
- Livestock science 2020 v.231 pp. 103871
- ISSN:
- 1871-1413
- Subject:
- animal models; blood plasma; blood sampling; brain; cerebrospinal fluid; corticotropin; corticotropin-releasing hormone; cortisol; early lactation; mice; pregnancy; protective effect; rats; sheep; temporal variation
- Abstract:
- ... Research on pregnant mice and rats indicated that a neurosteroid allopregnanolone (AP) might have a stress-protective effect, decreasing the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Using a sheep model in the present research, we tested a hypothesis that the cerebrospinal fluid (CSF) AP concentration changes during pregnancy and early lactation, keeping in check the secretory act ...
- DOI:
- 10.1016/j.livsci.2019.103871
- https://doi.org/10.1016/j.livsci.2019.103871
- Author:
- Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
- Source:
- Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
- ISSN:
- 0006-291X
- Subject:
- CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
- Abstract:
- ... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
- DOI:
- 10.1016/j.bbrc.2019.03.002
- https://doi.org/10.1016/j.bbrc.2019.03.002
- Author:
- Vladimir Korzh
- Source:
- Cellular and molecular life sciences 2018 v.75 no.3 pp. 375-383
- ISSN:
- 1420-682X
- Subject:
- Danio rerio; animal models; brain; cerebrospinal fluid; choroid plexus; cilia; domestic animals; genetics; hamsters; humans; hydrocephalus; inflation; mice; mutants; neurodegenerative diseases; rats
- Abstract:
- ... The brain ventricular system (BVS) consists of brain ventricles and channels connecting ventricles filled with cerebrospinal fluid (CSF). The disturbance of CSF flow has been linked to neurodegenerative disease including hydrocephalus, which manifests itself as an abnormal expansion of BVS. This relatively common developmental disorder has been observed in human and domesticated animals and linked ...
- DOI:
- 10.1007/s00018-017-2605-y
- PubMed:
- 28780589
- PubMed Central:
- PMC5765195
- https://doi.org/10.1007/s00018-017-2605-y
- Author:
- Shintaro Ogawa; Miho Ota; Jun Ogura; Koichi Kato; Hiroshi Kunugi
- Source:
- Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
- ISSN:
- 2475-2991
- Subject:
- amino acid composition; animal models; anxiety; cerebellum; cerebrospinal fluid; elevated plus-maze test; glutamic acid; high performance liquid chromatography; hippocampus; laboratory animals; life insurance; mental depression; methionine; positron-emission tomography; rats; tranquilizers; Japan
- Abstract:
- ... L-theanine (N-ethyl-L-glutamine), an amino acid is well known as a relaxing agent. In the present study, we examined the effects of repeated L-theanine administration on behavior, hippocampal activity in Wistar Kyoto (WKY) rats, levels of amino acids in the cerebrospinal fluid (CSF), and studied an animal model of anxiety and depressive disorders. Behavioral tests were performed after 7–10 days of ...
- DOI:
- 10.1093/cdn/nzz052.P14-022-19
- https://doi.org/10.1093/cdn/nzz052.P14-022-19
- Author:
- Mitra Ansari Dezfouli; Maryam Zahmatkesh; Maryam Farahmandfar; Fariba Khodagholi
- Source:
- Physiology & behavior 2019 v.204 pp. 65-75
- ISSN:
- 0031-9384
- Subject:
- Alzheimer disease; amyloid; animal models; antioxidant activity; antioxidants; anxiety; biogenesis; cerebrospinal fluid; clinical trials; cognition; cognitive disorders; hippocampus; melatonin; memory; mitochondria; mitochondrial DNA; neuroprotective effect; neurotoxicity; patients; rats; signal transduction; therapeutics; transcription factors
- Abstract:
- ... Melatonin has a potential therapeutic value in Alzheimer's disease (AD), a disease that is associated with a dramatic decline in memory and cognitive abilities. The aggregation of the amyloid β (Aβ) peptide, a hallmark of AD, deactivates mitochondrial biogenesis and antioxidant defenses. Melatonin as an endogenous antioxidant, decreases in plasma and cerebrospinal fluid of AD patients. Even though ...
- DOI:
- 10.1016/j.physbeh.2019.02.016
- https://doi.org/10.1016/j.physbeh.2019.02.016
- Author:
- Justin Ng; Roger D. Kamm; Thorsten Wohland; Rachel S. Kraut
- Source:
- Journal of molecular biology 2018 v.430 no.18 pp. 3439-3453
- ISSN:
- 0022-2836
- Subject:
- Alzheimer disease; animal models; brain; cell death; cerebrospinal fluid; cognitive disorders; cytotoxicity; fluorescence; fluorescence correlation spectroscopy; lipid bilayers; membrane fluidity; neurons; patients; plasma membrane; viability
- Abstract:
- ... The amyloid-beta (Aβ) peptide, commonly found in elevated levels in the brains of patients with Alzheimer's disease (AD) and in the cerebrospinal fluid of individuals presenting mild cognitive impairment, is thought to be one of the major factors resulting in the onset of AD. Although observed and studied at the molecular level for several decades, the exact disease pathology of AD is still not to ...
- DOI:
- 10.1016/j.jmb.2018.04.030
- https://doi.org/10.1016/j.jmb.2018.04.030
22. GAPDH-targeted therapy – A new approach for secondary damage after traumatic brain injury on rats
- Author:
- Vladimir F. Lazarev; Elizaveta A. Dutysheva; Elena Y. Komarova; Elena R. Mikhaylova; Irina V. Guzhova; Boris A. Margulis
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1003-1008
- ISSN:
- 0006-291X
- Subject:
- animal models; antibodies; brain; brain damage; cell death; cell membranes; cerebrospinal fluid; cortisol; cytotoxicity; death; extracellular space; glyceraldehyde-3-phosphate dehydrogenase; ischemia; neurons; polypeptides; proteins; rats; therapeutics
- Abstract:
- ... Massive neuronal death caused by a neurodegenerative pathology or damage due to ischaemia or traumatic brain injury leads to the appearance of cytosolic proteins in the extracellular space. We found that one of the most abundant cellular polypeptides, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), appearing in the medium of dying cells or body fluids is able to form aggregates that are cytotoxi ...
- DOI:
- 10.1016/j.bbrc.2018.05.099
- https://doi.org/10.1016/j.bbrc.2018.05.099
- Author:
- Linsheng Liu; Chenrong Huang; Yicong Bian; Liyan Miao
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- alanine; alcohols; animal models; aspartic acid; blood serum; carbohydrates; cefoperazone; cerebrospinal fluid; citrates; energy metabolism; gas chromatography-mass spectrometry; glutamic acid; ingestion; leucine; metabolites; metabolomics; phenotype; pyruvic acid; rats; synaptic transmission; tricarboxylic acid cycle; valine
- Abstract:
- ... Cefoperazone is most popularly used in the treatment of complicated infections clinically. Concomitant ingestion of ethnaol and cefoperazone may cause a disulfiram-like reaction. However, very little is known about the possible interactions between cefoperazone treatment and an alcohol with regard to the induction of disulfiram-like reaction. Study of the metabolic impact of cotreatment with cefop ...
- DOI:
- 10.1016/j.bbrc.2017.06.167
- https://doi.org/10.1016/j.bbrc.2017.06.167
- Author:
- Mahendra Kumar Trivedi; Mayank Gangwar; Sambhu Charan Mondal; Snehasis Jana
- Source:
- Biological trace element research 2018 v.182 no.2 pp. 265-277
- ISSN:
- 0163-4984
- Subject:
- animal models; animals; antibodies; antioxidants; biomarkers; cell-mediated immunity; cerebrospinal fluid; corticosterone; curcumin; delayed hypersensitivity; dietary supplements; disease control; dopamine; free radicals; hemagglutination; hematology; immune system; immunoglobulin E; immunoglobulin G; immunoglobulin M; immunosuppression; lipid composition; lipids; liquid chromatography; mass spectrometry; medicinal properties; serotonin; superoxide dismutase; trace elements; vitamins
- Abstract:
- ... The present paper described the immunomodulatory potential of novel nanocurcumin-based formulation enriched with trace elements and vitamins on cyclophosphamide-induced immunosuppression in rat model. Major immune-related assays were monitored such as hemagglutination assay, delayed-type hypersensitivity (DTH) reaction, cellular immune response, IgG, IgE, IgM, cerebrospinal fluid biomarkers, hemat ...
- DOI:
- 10.1007/s12011-017-1082-3
- https://doi.org/10.1007/s12011-017-1082-3
- Author:
- María F. Zappa-Villar; Micaela López-León; Joaquín Pardo; Mariana Costa; Rosana Crespo; Mireille Dardenne; Rodolfo G. Goya; Paula C. Reggiani
- Source:
- Molecular Immunology 2017 v.87 pp. 180-187
- ISSN:
- 0161-5890
- Subject:
- animal models; anti-inflammatory activity; blood serum; cerebrospinal fluid; dose response; doxycycline; drinking water; gene expression; gene therapy; green fluorescent protein; inflammation; promoter regions; rats; regulatory proteins; synthetic genes; transgenes
- Abstract:
- ... Thymulin is a thymic peptide possessing anti-inflammatory effects. In order to manipulate thymulin expression in gene therapy studies, we built a bidirectional regulatable two-vector Tet-Off system and the corresponding control system. The experimental two-vector system, ETV, consists of a recombinant adenovector (RAd) harboring an expression cassette centered on a Tet-Off bidirectional promoter f ...
- DOI:
- 10.1016/j.molimm.2017.04.014
- https://doi.org/10.1016/j.molimm.2017.04.014
- Author:
- Anders Backer-Grøndahl; Sigurd Lindal; Merethe Andberg Lorentzen; Petter Eldevik; Torgrim Vorren; Bente Kristiansen; Torgil Vangberg; Lars Marius Ytrebø
- Source:
- Laboratory animals 2016 v.50 no.5 pp. 379-389
- ISSN:
- 1758-1117
- Subject:
- Norwegian Landrace (swine breed); aneurysm; animal models; blood; brain; bulbs; cerebrospinal fluid; death; edema; hemodynamics; hemorrhage; humans; laboratory animals; light microscopy; monitoring; necropsy; normal values; swine
- Abstract:
- ... Subarachnoid hemorrhage (SAH) from rupture of an intracranial arterial aneurysm is a devastating disease affecting young people, with serious lifelong disability or death as a frequent outcome. Large animal models that exhibit all the cardinal clinical features of human SAH are highly warranted. In this pilot study we aimed to develop a non-craniotomy model of SAH in pigs suitable for acute interv ...
- DOI:
- 10.1177/0023677215619806
- https://doi.org/10.1177/0023677215619806
- Author:
- Gabriela Dumitrita Stanciu; Gheorghe Solcan
- Source:
- BMC veterinary research 2016 v.12 no.1 pp. 111
- ISSN:
- 1746-6148
- Subject:
- Procyon lotor; action potentials; animal models; antibodies; cerebellum; cerebrospinal fluid; cholinergic receptors; clinical examination; dissociation; dogs; dysphagia; electromyography; females; motor neurons; muscles; nerve tissue; neurotoxins; patients; peripheral nerves; protein content; reflexes; synapse; vaccination
- Abstract:
- ... BACKGROUND: Acute Idiopathic Polyradiculoneuritis, an animal model for the axonal form of the Guillain – Barre Syndrome in humans and the acquired myasthenia gravis are different autoimmune disorders affecting the peripheral nerves and the neuromuscular junction, respectively. Both lead to muscle weakness and possible respiratory failure. The coexistence of these two entities combined in the same ...
- DOI:
- 10.1186/s12917-016-0729-1
- PubMed:
- 27301259
- PubMed Central:
- PMC4908694
- https://doi.org/10.1186/s12917-016-0729-1
- Author:
- Léo Houdebine; Cristina Anna Gallelli; Marialetizia Rastelli; Nirmal Kumar Sampathkumar; Julien Grenier
- Source:
- Chemistry and physics of lipids 2017 v.207 pp. 127-134
- ISSN:
- 0009-3084
- Subject:
- animal models; blood; brain; cerebrospinal fluid; cholesterol metabolism; disease course; exercise; inflammation; neurodegenerative diseases; neurons; neuroplasticity; oxidative stress; oxysterols; patients; sclerosis
- Abstract:
- ... Multiple sclerosis (MS) is a central nervous demyelinating disease characterized by cyclic loss and repair of myelin sheaths associated with chronic inflammation and neuronal loss. This degenerative pathology is accompanied by modified levels of oxysterols (oxidative derivatives of cholesterol, implicated in cholesterol metabolism), highlighted in the brain, blood and cerebrospinal fluid of MS pat ...
- DOI:
- 10.1016/j.chemphyslip.2017.06.002
- https://doi.org/10.1016/j.chemphyslip.2017.06.002
- Author:
- Fan Zhang; J. Trent Magruder; Yi-An Lin; Todd C. Crawford; Joshua C. Grimm; Christopher M. Sciortino; Mary Ann Wilson; Mary E. Blue; Sujatha Kannan; Michael V. Johnston; William A. Baumgartner; Rangaramanujam M. Kannan
- Source:
- Journal of Controlled Release 2017 v.249 pp. 173-182
- ISSN:
- 0168-3659
- Subject:
- animal models; blood circulation; blood serum; brain; cerebrospinal fluid; dogs; drugs; intravenous injection; liver; neuroglia; neurons; neuroprotective effect; pharmacokinetics; renal clearance; spleen; surgery
- Abstract:
- ... Hypothermic circulatory arrest (HCA) provides neuroprotection during cardiac surgery but entails an ischemic period that can lead to excitotoxicity, neuroinflammation, and subsequent neurologic injury. Hydroxyl polyamidoamine (PAMAM) dendrimers target activated microglia and damaged neurons in the injured brain, and deliver therapeutics in small and large animal models. We investigated the effect ...
- DOI:
- 10.1016/j.jconrel.2017.01.032
- PubMed:
- 28137632
- PubMed Central:
- PMC5323327
- https://doi.org/10.1016/j.jconrel.2017.01.032
- Author:
- Maxwell W. Waema; Naomi W. Maina; Maina Ngotho; Simon M. Karanja; Beatrice M. Gachie; Dawn N. Maranga; John M. Kagira
- Source:
- Acta tropica 2017 v.168 pp. 45-49
- ISSN:
- 0001-706X
- Subject:
- African trypanosomiasis; Trypanosoma brucei brucei; animal models; biomarkers; blood serum; cerebrospinal fluid; diminazene; enzyme-linked immunosorbent assay; humans; immunoglobulin G; immunoglobulin M; interleukin-6; intravenous injection; monitoring; monkeys; parasitemia; parasites; patients; relapse
- Abstract:
- ... Human African trypanosomiasis (HAT) patients manifest immunological profiles, whose variations over time can be used to indicate disease progression. However, monitoring of these biomarkers in human patients is beset by several limitations which can be offset by using chronic animal models. A recent improved monkey model of HAT using a Trypanosoma brucei brucei isolate has been developed but the i ...
- DOI:
- 10.1016/j.actatropica.2017.01.012
- https://doi.org/10.1016/j.actatropica.2017.01.012
- Author:
- Volker Strenger; Fedja Farowski; Carsten Müller; Nora Hofer; Hans Jürgen Dornbusch; Daniela Sperl; Herwig Lackner; Martin Benesch; Christian Urban
- Source:
- International journal of antimicrobial agents 2017 v.50 no.2 pp. 272-275
- ISSN:
- 0924-8579
- Subject:
- animal models; anti-infective agents; blood serum; caspofungin; cerebrospinal fluid; detection limit; fungi; humans; intravenous injection; liquid chromatography; meninges; meningitis; patients; tandem mass spectrometry
- Abstract:
- ... The kinetics of caspofungin (CAS) in cerebrospinal fluid (CSF) following intravenous (i.v.) administration has been studied exclusively in animal models. Human data are missing so far. In this study, 13 CSF samples were obtained at different time points following i.v. infusion of CAS in ten paediatric haemato-/oncological patients (age range 1.0–14.2 years, median 8.6 years) without signs of centr ...
- DOI:
- 10.1016/j.ijantimicag.2017.02.024
- https://doi.org/10.1016/j.ijantimicag.2017.02.024
- Author:
- Ying Shi; Wanxiang Qin; Fachuan Nie; Huizhong Wen; Kaizhi Lu; Jian Cui
- Source:
- Gene 2017 v.627 pp. 263-270
- ISSN:
- 0378-1119
- Subject:
- AMP-activated protein kinase; adenosine triphosphate; animal models; anti-inflammatory activity; cerebrospinal fluid; drugs; hypersensitivity; immunohistochemistry; luciferase; nerve tissue; neuroglia; neuroprotective effect; pain; proteinase inhibitors; rats; serine proteinases; spinal cord
- Abstract:
- ... Ulinastatin, a serine protease inhibitor, which has anti-inflammatory properties and neuroprotective effects, is used to treat acute inflammatory disorders. Recent evidence indicates that administration of ulinastatin alleviates pain in rat model of neuropathic pain (NPP). However, its effect on NPP and the underlying mechanism requires further study. In this study, we evaluated the role of intrat ...
- DOI:
- 10.1016/j.gene.2017.06.045
- https://doi.org/10.1016/j.gene.2017.06.045
- Author:
- Leonie Gouweleeuw; Iris B. Hovens; Hui Liu; Petrus J.W. Naudé; Regien G. Schoemaker
- Source:
- Physiology & behavior 2016 v.163 pp. 7-16
- ISSN:
- 0031-9384
- Subject:
- animal models; anxiety; cerebrospinal fluid; cognition; coronary vessels; females; gender differences; heart; heart failure; hemodynamics; lungs; males; myocardial infarction; neutrophils; paraventricular hypothalamic nucleus; patients; prognosis; rats; risk; surgery; thorax; women; young adults
- Abstract:
- ... Heart failure is associated with an increased risk of developing depression and cognitive dysfunction, which negatively affects prognosis. Plasma levels of neutrophil gelatinase associated lipocalin (NGAL) are increased in heart failure and depression. Moreover, NGAL levels are associated with depression in heart failure patients. Since women are at a higher risk of developing comorbid depression ...
- DOI:
- 10.1016/j.physbeh.2016.04.040
- https://doi.org/10.1016/j.physbeh.2016.04.040
- Author:
- Y. Murayama; F. Ono; N. Shimozaki; H. Shibata
- Source:
- Biochemical and biophysical research communications 2016 v.470 pp. 563-568
- ISSN:
- 0006-291X
- Subject:
- Creutzfeldt-Jakob Syndrome; Macaca; PrPSc proteins; animal models; anions; blood; bovine spongiform encephalopathy; brain; cerebrospinal fluid; diagnostic techniques; humans; mice; phosphotungstic acid; saliva; urine
- Abstract:
- ... Protease-resistant, misfolded isoforms (PrPSc) of a normal cellular prion protein (PrPC) in the bodily fluids, including blood, urine, and saliva, are expected to be useful diagnostic markers of prion diseases, and nonhuman primate models are suited for performing valid diagnostic tests for human Creutzfeldt-Jakob disease (CJD). We developed an effective amplification method for PrPSc derived from ...
- DOI:
- 10.1016/j.bbrc.2016.01.105
- https://doi.org/10.1016/j.bbrc.2016.01.105
- Author:
- Zhou Tan; Rui Liu; Le Zheng; Shiying Hao; Changlin Fu; Zhen Li; Xiaohong Deng; Taichang Jang; Milton Merchant; John C. Whitin; Minyi Guo; Harvey J. Cohen; Lawrence Recht; Xuefeng B. Ling
- Source:
- Methods 2015 v.83 pp. 36-43
- ISSN:
- 1046-2023
- Subject:
- Internet; animal models; brain; carcinogenesis; cerebrospinal fluid; early development; entropy; hyperplasia; neoplasms; pathophysiology; proteins; proteome; proteomics; rats; therapeutics
- Abstract:
- ... To get a better understanding of the ongoing in situ environmental changes preceding the brain tumorigenesis, we assessed cerebrospinal fluid (CSF) proteome profile changes in a glioma rat model in which brain tumor invariably developed after a single in utero exposure to the neurocarcinogen ethylnitrosourea (ENU). Computationally, the CSF proteome profile dynamics during the tumorigenesis can be ...
- DOI:
- 10.1016/j.ymeth.2015.05.004
- https://doi.org/10.1016/j.ymeth.2015.05.004
- Author:
- M. Vivas; E. Force; F. Tubau; C. El Haj; J. Ariza; C. Cabellos
- Source:
- International journal of antimicrobial agents 2015 v.46 no.1 pp. 28-32
- ISSN:
- 0924-8579
- Subject:
- Streptococcus pneumoniae; animal models; cerebrospinal fluid; daptomycin; dexamethasone; meningitis; minimum inhibitory concentration; plate count; rabbits; therapeutics
- Abstract:
- ... This study aimed to determine the effect of dexamethasone in combination with low-dose or high-dose daptomycin for the treatment of penicillin- and cephalosporin-resistant pneumococcal meningitis. Efficacy (ΔCFU/mL) and cerebrospinal fluid (CSF) levels of daptomycin at 15mg/kg and 25mg/kg were studied in a rabbit model of pneumococcal meningitis, comparing them with the same doses in combination w ...
- DOI:
- 10.1016/j.ijantimicag.2015.01.014
- https://doi.org/10.1016/j.ijantimicag.2015.01.014
- Author:
- Joanne Livermore; Susan J. Howard; Andrew D. Sharp; Joanne Goodwin; Lea Gregson; Timothy Felton; Julie A. Schwartz; Catherine Walker; Bill Moser; Werner Müller; Thomas S. Harrison; John R. Perfect; William W. Hope
- Source:
- mBio 2014 v.5 no.1 pp. e00725-13
- ISSN:
- 2150-7511
- Subject:
- amphotericin B; animal models; antifungal properties; cerebrospinal fluid; cerebrum; clinical trials; drugs; health services; humans; laboratory animals; mathematical models; meningoencephalitis; mice; morbidity; mortality; patients; rabbits; therapeutics
- Abstract:
- ... Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care but may not be suitable for resource-poor settings. We investigated the efficacy of conventional and abbreviated regimens of dAmB for cryptococcal meningoencephalitis in both murine and rabbit models of cryptococcal meningoe ...
- DOI:
- 10.1128/mBio.00725-13
- PubMed:
- 24473125
- PubMed Central:
- PMC3903272
- https://doi.org/10.1128/mBio.00725-13
- Author:
- Wiesław Wiczkowski; Janina Skipor; Tomasz Misztal; Dorota Szawara‐Nowak; Joanna Topolska; Mariusz K. Piskula
- Source:
- Molecular nutrition & food research 2015 v.59 no.6 pp. 1088-1094
- ISSN:
- 1613-4125
- Subject:
- animal models; blood plasma; brain; cannulas; cerebrospinal fluid; foods; in vitro studies; isorhamnetin; metabolites; onions; permeability; protective effect; quercetin; sheep; urine
- Abstract:
- ... SCOPE: Reports on the protective effect of certain foods on brain functions are numerous; however, the permeability of the brain barriers by food components is still hardly recognised. There have been in vitro studies aimed at demonstrating this possibility, but not much is known about this phenomenon in in vivo systems. The objective of the study was to determine the metabolites of dietary querce ...
- DOI:
- 10.1002/mnfr.201400567
- https://doi.org/10.1002/mnfr.201400567
- Author:
- Zhifeng Chen; Ersong Wang; Rong Hu; Yu Sun; Lei Zhang; Jue Jiang; Ying Zhang; Hong Jiang
- Source:
- Biochemical and biophysical research communications 2015 v.468 pp. 400-407
- ISSN:
- 0006-291X
- Subject:
- Parkinson disease; animal models; apoptosis; biomarkers; caspase-3; cell culture; cell viability; cerebrospinal fluid; gene deletion; mice; neurons; patients; small interfering RNA; transgenic animals; tyrosine 3-monooxygenase
- Abstract:
- ... Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). We previously identified tetranectin (TET) as a potential biomarker for PD whose expression is downregulated in the cerebrospinal fluid of PD patients. In the present study, we investigate the role of TET in neurodegene ...
- DOI:
- 10.1016/j.bbrc.2015.10.118
- https://doi.org/10.1016/j.bbrc.2015.10.118
- Author:
- Orit Chai; Adi Sommer; Gabriel Zimmerman; Hermona Soreq; Alon Friedman; Tali Bdolah-Abram; Itamar Aroch; Merav H. Shamir
- Source:
- veterinary journal 2013 v.198 no.1 pp. 292-294
- ISSN:
- 1090-0233
- Subject:
- acetylcholinesterase; animal models; blood serum; cerebrospinal fluid; dogs; intervertebral disks; seizures
- Abstract:
- ... Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the ‘readthrough’ acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy do ...
- DOI:
- 10.1016/j.tvjl.2013.06.027
- https://doi.org/10.1016/j.tvjl.2013.06.027
- Author:
- Haußmann Ute; Jahn Olaf; Linning Philipp; Janßen Christin; Liepold Thomas; Portelius Erik; Zetterberg Henrik; Bauer Chris; Schuchhardt Johannes; Knölker Hans-Joachim; Klafki Hans; Wiltfang Jens
- Source:
- Analytical chemistry 2013 v.85 no.17 pp. 8142-8149
- ISSN:
- 1520-6882
- Subject:
- animal models; cell culture; cerebrospinal fluid; immunoassays; isoelectric focusing; mass spectrometry; peptides; precipitin tests
- Abstract:
- ... Here we present a novel assay for the separation and detection of amino-terminal amyloid-β (Aβ) peptide variants by capillary isoelectric focusing (CIEF) immunoassay. Specific amino-terminally truncated Aβ peptides appear to be generated by β-secretase (BACE1)-independent mechanisms and have previously been observed in cerebrospinal fluid (CSF) after BACE1 inhibitor treatment in an animal model. C ...
- DOI:
- 10.1021/ac401055y
- https://doi.org/10.1021/ac401055y
- Author:
- Peter Bukovics; Endre Czeiter; Krisztina Amrein; Noemi Kovacs; Jozsef Pal; Andrea Tamas; Terez Bagoly; Zsuzsanna Helyes; Andras Buki; Dora Reglodi
- Source:
- Peptides 2014 v.60 pp. 18-22
- ISSN:
- 0196-9781
- Subject:
- animal models; blood serum; blood-brain barrier; brain damage; cerebrospinal fluid; coma; death; humans; immunologic factors; migraine; neuroprotective effect; nutritional status; patients; prognosis
- Abstract:
- ... PACAP has well-known neuroprotective potential including traumatic brain injury (TBI). Its level is up-regulated following various insults of the CNS in animal models. A few studies have documented alterations of PACAP levels in human serum. The time course of post-ictal PACAP levels, for example, show correlation with migraine severity. Very little is known about the course of PACAP levels follow ...
- DOI:
- 10.1016/j.peptides.2014.07.001
- https://doi.org/10.1016/j.peptides.2014.07.001
- Author:
- Peng Jun; Guo Kevin; Xia Jianguo; Zhou Jianjun; Yang Jing; Westaway David; Wishart David S.; Li Liang
- Source:
- Journal of Proteome Research 2014 v.13 no.10 pp. 4457-4469
- ISSN:
- 1535-3907
- Subject:
- 5-hydroxyindoleacetic acid; Alzheimer disease; amines; amyloid; animal models; biomarkers; blood sampling; carbon; cerebrospinal fluid; humans; isotope labeling; liquid chromatography; mass spectrometry; metabolites; metabolome; metabolomics; methionine; mice; phenols; phenotype; stable isotopes; statistical analysis; taurine; transgenic animals; urine
- Abstract:
- ... Because of a limited volume of urine that can be collected from a mouse, it is very difficult to apply the common strategy of using multiple analytical techniques to analyze the metabolites to increase the metabolome coverage for mouse urine metabolomics. We report an enabling method based on differential isotope labeling liquid chromatography mass spectrometry (LC–MS) for relative quantification ...
- DOI:
- 10.1021/pr500828v
- https://doi.org/10.1021/pr500828v
- Author:
- Andrej Kovac; Zuzana Somikova; Norbert Zilka; Michal Novak
- Source:
- Talanta 2014 v.119 pp. 284-290
- ISSN:
- 0039-9140
- Subject:
- 5-hydroxyindoleacetic acid; Alzheimer disease; animal models; biomarkers; cerebrospinal fluid; chlorides; derivatization; dopamine; epinephrine; gamma-aminobutyric acid; glutamic acid; histamine; humans; metabolites; neurodegenerative diseases; neurotransmitters; norepinephrine; organochlorine compounds; quantitative analysis; regression analysis; serotonin; tandem mass spectrometry; ultra-performance liquid chromatography
- Abstract:
- ... Alzheimer's disease (AD) is still being recognized today as an unmet medical need. Currently, there is no cure and early preclinical diagnostic assay available for AD. Therefore much attention is now being directed at the development of novel methods for quantitative determination of AD biomarkers in the cerebrospinal fluid (CSF). Here, we describe the liquid chromatography–tandem mass spectrometr ...
- DOI:
- 10.1016/j.talanta.2013.10.027
- https://doi.org/10.1016/j.talanta.2013.10.027
- Author:
- Oliver K. Appelbe; Bryan Bollman; Ali Attarwala; Lindy A. Triebes; Hilmarie Muniz-Talavera; Daniel J. Curry; Jennifer V. Schmidt
- Source:
- Developmental biology 2013 v.382 no.1 pp. 172-185
- ISSN:
- 0012-1606
- Subject:
- animal models; bacterial artificial chromosomes; brain; cerebrospinal fluid; children; cilia; early development; homeostasis; humans; hydrocephalus; juveniles; mice; microtubules; transgenes; transgenic animals
- Abstract:
- ... Congenital hydrocephalus, the accumulation of excess cerebrospinal fluid (CSF) in the ventricles of the brain, affects one of every 1000 children born today, making it one of the most common human developmental disorders. Genetic causes of hydrocephalus are poorly understood in humans, but animal models suggest a broad genetic program underlying the regulation of CSF balance. In this study, the ra ...
- DOI:
- 10.1016/j.ydbio.2013.07.003
- PubMed:
- 23906841
- PubMed Central:
- PMC3783533
- https://doi.org/10.1016/j.ydbio.2013.07.003
- Author:
- A. Stucki; M. Cottagnoud; F. Acosta; U. Egerman; J. Läuffer; P. Cottagnoud
- Source:
- Antimicrobial agents and chemotherapy 2012 v.56 no.2 pp. 921-925
- ISSN:
- 0066-4804
- Subject:
- Escherichia coli; Gram-negative bacteria; Haemophilus influenzae; Klebsiella pneumoniae; Staphylococcus aureus; animal models; antibacterial properties; antibiotic resistance; beta-lactamase; blood serum; cephalosporins; cerebrospinal fluid; meninges; meningitis; methicillin; pathogens; rabbits
- Abstract:
- ... Ceftobiprole medocaril, a new cephalosporin, is highly active against a broad spectrum of Gram-positive and Gram-negative clinical pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant pneumococci. In this study, we tested ceftobiprole against various Gram-negative pathogens in a rabbit meningitis model and determined its penetration into the cerebrospina ...
- DOI:
- 10.1128/AAC.01537-10
- PubMed:
- 22064544
- PubMed Central:
- PMC3264204
- https://doi.org/10.1128/AAC.01537-10
- Author:
- Sen Arundhuti; Wang Yaoyao; Chiu Kin; Whiley Luke; Cowan David; Chang RaymondChuen-Chung; Legido-Quigley Cristina
- Source:
- Analytical chemistry 2013 v.85 no.15 pp. 7257-7263
- ISSN:
- 1520-6882
- Subject:
- animal models; blood serum; cerebrospinal fluid; ionization; liquid chromatography; mass spectrometry; metabolomics; mice; phenotype; rats; statistical analysis; urine
- Abstract:
- ... High-throughput multiplatform metabolomics experiments are becoming an integral part of clinical and systems biology research. Such methods call for the adoption of robust sample storage and transport formats for small volumes of biofluids. One such format is the dried biofluid spot, which combines small volume requirements with easy portability. Here, we describe ultra high-performance liquid chr ...
- DOI:
- 10.1021/ac401149w
- https://doi.org/10.1021/ac401149w
- Author:
- Fabiana HG Farias; Rong Zeng; Gary S Johnson; G D Shelton; Dominique Paquette; Dennis P O’Brien
- Source:
- BMC veterinary research 2012 v.8 no.1 pp. 386
- ISSN:
- 1746-6148
- Subject:
- magnetic resonance imaging; proteins; urine; dementia; dog diseases; aggression; dogs; brain; acids; mutation; cerebrospinal fluid; terriers; animal models; methionine; seizures; pathogenesis; start codon; blood
- Abstract:
- ... BACKGROUND: L-2-hydroxyglutaric aciduria is a metabolic repair deficiency characterized by elevated levels of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid. Neurological signs associated with the disease in humans and dogs include seizures, ataxia and dementia. CASE PRESENTATION: Here we describe an 8 month old Yorkshire terrier that presented with episodes of hyperactivity and ...
- DOI:
- 10.1186/1746-6148-8-124
- PubMed:
- 22834903
- PubMed Central:
- PMC3461439
- https://doi.org/10.1186/1746-6148-8-124
- Author:
- P. Vogel; R. W. Read; G. M. Hansen; B. J. Payne; D. Small; A. T. Sands; B. P. Zambrowicz
- Source:
- Veterinary pathology v.49 no.1 pp. 166-181
- ISSN:
- 1544-2217
- Subject:
- alleles; animal diseases; animal models; cerebrospinal fluid; humans; hydrocephalus; mice; modifiers (genes); neurodevelopment
- Abstract:
- ... There is evidence that genetic factors play a role in the complex multifactorial pathogenesis of hydrocephalus. Identification of the genes involved in the development of this neurologic disorder in animal models may elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans. The authors report here a brief summary of findings from 12 lines of genet ...
- DOI:
- 10.1177/0300985811415708
- PubMed:
- 21746835
- https://doi.org/10.1177/0300985811415708
- Author:
- LING-YUH SHYU; HAN-HSIN CHANG; JENG-DONG HSU; DAVID PEI-CHENG LIN; YING-HOCK TENG; HSIU-HSIUNG LEE
- Source:
- Parasitology 2012 v.139 no.3 pp. 358-365
- ISSN:
- 1469-8161
- Subject:
- Parastrongylus cantonensis; albendazole; animal models; anti-inflammatory agents; brain; cerebrospinal fluid; curcumin; eosinophils; immune response; larvae; meningitis; mice; therapeutics; tissues
- Abstract:
- ... Angiostrongylus cantonensis (A. cantonensis) is the most common cause of parasitic eosinophilic meningitis worldwide. By using an animal model of BALB/c mice infected with A. cantonensis, previous studies indicated that the anthelmintic drug, albendazole, could kill A. cantonensis larvae and prevent further infection. However, the dead larvae will induce severe immune responses targeting at brain ...
- DOI:
- 10.1017/S0031182011001922
- PubMed:
- 22053741
- https://doi.org/10.1017/S0031182011001922