U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject term animal models Remove constraint Subject term: animal models Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
Start Over

Search

25,117  Search Results

« Previous | 1 - 20 of 25,117 |
Number of results to display per page

Search Results

1. (-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage

Author:
M Ramírez-Ramírez; F Fernández-Valverde; A Reséndiz-García; MG Martínez-Damas; Luis Javier Cano-Martínez; A Zentella-Dehesa; RM Coral-Vázquez
Source:
Journal of nutritional biochemistry 2022 pp. 109069
ISSN:
0955-2863
Subject:
Western blotting; animal models; antioxidants; diabetes; epicatechin; histology; hypertrophy; mice; muscle development; muscles; muscular dystrophy; myogenin; sarcopenia; skeletal muscle; therapeutics
Abstract:
... Several studies have shown the beneficial effect that Epicatechin (Epi) has on the skeletal muscle of murine models and patients with muscular dystrophy and in the muscles of patients with diabetes or murine sarcopenia models. This flavanol has been shown to enhance antioxidant pathways and improve muscle architecture. However, the repair process during muscle regeneration has not been analyzed. T ...
DOI:
10.1016/j.jnutbio.2022.109069

2. (–)-Epicatechin Improves Vasoreactivity and Mitochondrial Respiration in Thermoneutral-Housed Wistar Rat Vasculature

Author:
Ji Hye Chun; Melissa M. Henckel; Leslie A. Knaub; Sara E. Hull; Greg B. Pott; Lori A. Walker; Jane E.-B. Reusch; Amy C. Keller
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
ambient temperature; animal models; body weight; calcium-calmodulin-dependent protein kinase; cardiovascular diseases; endothelium; mitochondria; protein synthesis; rats; therapeutics; vasodilation
Abstract:
... Cardiovascular disease (CVD) is a global health concern. Vascular dysfunction is an aspect of CVD, and novel treatments targeting vascular physiology are necessary. In the endothelium, eNOS regulates vasodilation and mitochondrial function; both are disrupted in CVD. (–)-Epicatechin, a botanical compound known for its vasodilatory, eNOS, and mitochondrial-stimulating properties, is a potential the ...
DOI:
10.3390/nu14051097

3. 1H NMR serum metabolomics and its endogenous network pharmacological analysis of Gushudan on kidney-yang-deficiency-syndrome rats

Author:
Qisheng Feng; Lin Tong; Qing Lu; Shuo Liu; Longshan Zhao; Zhili Xiong
Source:
Analytical biochemistry 2022 v.643 pp. 114580
ISSN:
0003-2697
Subject:
Oriental traditional medicine; amino acid metabolism; animal models; arginine; biochemical pathways; biomarkers; blood serum; carbohydrate metabolism; cortisol; dicarboxylic acids; intestinal microorganisms; kidneys; metabolomics; pharmacodynamics; proline
Abstract:
... The pharmacodynamics, ¹H NMR metabolomics and endogenous network pharmacology strategy approaches were integrated to investigate the preventive mechanism of Gushudan (GSD) on kidney-yang-deficiency-syndrome (KYDS) rats in this study. Firstly, the KYDS rat model was achieved by hydrocortisone induction, and the efficacy of GSD on KYDS model rats was assessed by the pharmacodynamic indicators. Next, ...
DOI:
10.1016/j.ab.2022.114580

4. 2-tert-Butyl-1,4-benzoquinone, a food additive oxidant, reduces virulence factors of Chromobacterium violaceum

Author:
Kai-Zhong Xu; Xiao-Juan Tan; Zeng-Yan Chang; Jun-Jian Li; Ai-Qun Jia
Source:
Lebensmittel-Wissenschaft + Technologie 2022 pp. 113569
ISSN:
0023-6438
Subject:
Caenorhabditis elegans; Chromobacterium violaceum; Salvia hispanica; animal models; biofilm; chitinase; ciprofloxacin; food additives; food industry; hemolysins; hydroquinone; multiple drug resistance; oxidants; quantitative polymerase chain reaction; survival rate; violacein; virulence
Abstract:
... Multi-drug resistant bacteria have been paying increasing attentions. Quorum sensing (QS) and QS-associated biofilms are showing the vital reasons for antibiotics resistant. In this study, 2-tert-butyl-1,4-benzoquinone (TBQ), the oxidant of tert-butyl hydroquinone (TBHQ), can potentially be the QS inhibitor (QSI) of Chromobacterium violaceum ATCC12472. After treated with 50 μg/mL of TBQ, the viola ...
DOI:
10.1016/j.lwt.2022.113569

5. 3D Printing Silk-Based Bioresorbable Piezoelectric Self-Adhesive Holey Structures for In Vivo Monitoring on Soft Tissues

Author:
Irene Chiesa; Carmelo De Maria; Maria Rachele Ceccarini; Lorenzo Mussolin; Riccardo Coletta; Antonino Morabito; Rodolfo Tonin; Martino Calamai; Amelia Morrone; Tommaso Beccari; Luca Valentini
Source:
ACS applied materials & interfaces 2022 v.14 no.17 pp. 19253-19264
ISSN:
1944-8252
Subject:
Castanea; animal models; biocompatibility; digestive tract; fibroins; humans; intestines; nanocomposites; polyphenols; three-dimensional printing
Abstract:
... Flexible and biocompatible adhesives with sensing capabilities can be integrated onto human body and organ surfaces, characterized by complex geometries, thus having the potential to sense their physiological stimuli offering monitoring and diagnosis of a wide spectrum of diseases. The challenges in this innovative field are the following: (i) the coupling method between the smart adhesive and the ...
DOI:
10.1021/acsami.2c04078

6. 3D-cultured small size adipose-derived stem cell spheroids promote bone regeneration in the critical-sized bone defect rat model

Author:
Yutaro Yamada; Tadashi Okano; Kumi Orita; Tomomi Makino; Fumiaki Shima; Hiroaki Nakamura
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 57-62
ISSN:
0006-291X
Subject:
angiogenesis; animal models; apoptosis; cartilage; gene expression; immunohistochemistry; morphogenesis; research; skull; stem cells; therapeutics
Abstract:
... Adipose-derived stem cells (ADSCs), due to their regenerative ability, have beneficial effects on bone and cartilage defects. In addition, spheroid formation of ADSCs obtained using three-dimensional (3D) culture accelerates the regenerative ability of ADSCs. The study investigated the regenerative effect of 3D-cultured small size ADSC spheroids without a scaffold in rats with defects in the criti ...
DOI:
10.1016/j.bbrc.2022.03.027

7. 3D-printable chitosan/silk fibroin/cellulose nanoparticle scaffolds for bone regeneration via M2 macrophage polarization

Author:
Dinesh K. Patel; Sayan Deb Dutta; Jin Hexiu; Keya Ganguly; Ki-Taek Lim
Source:
Carbohydrate polymers 2022 v.281 pp. 119077
ISSN:
0144-8617
Subject:
animal models; biodegradability; biopolymers; cellulose; chitosan; fibroins; humans; hydrogels; macrophages; skull; spectroscopy
Abstract:
... Biopolymers-induced immune microenvironment exhibited prominent effects on bone regeneration. Osteo-immunomodulatory responses of cellulose nanoparticles incorporated chitosan hydrogel scaffolds have not yet been reported. The objective of this study was to monitor the synergistic effects of silk fibroin and cellulose nanoparticles on the immune-modulatory behavior of chitosan biopolymer scaffolds ...
DOI:
10.1016/j.carbpol.2021.119077

8. 4-HIL mitigates type-2 diabetic complications through inhibiting inflammation and Nrf2 mediated oxidative stress in rats

Author:
Rupali Singh; Karan Singh Yadav; Ramanand Prajapati; Sharad Sharma; Srikanta Kumar Rath; Tadigoppula Narender; Madhav Nilakanth Mugale
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100141
ISSN:
2667-0313
Subject:
Trigonella foenum-graecum; animal models; antioxidants; blood serum; catalase; creatinine; eosin; gene expression; genes; glutathione; glycemic control; glycohemoglobin; histopathology; hyperglycemia; inflammation; insulin; insulin receptors; males; mechanism of action; metabolic syndrome; noninsulin-dependent diabetes mellitus; oral administration; oxidative stress; protective effect; rats; superoxide dismutase; triacylglycerols; urea nitrogen; vascular endothelial growth factors
Abstract:
... Hyperglycemia induced diabetic complications as well as dysfunction of multiple organs is closely related to the increased inflammation and oxidative stress (OS). 4-hydroxyisoleucine (4-HIL), a major constituent of Trigonella foenum-graecum L. shown to have anti-diabetic effects. However, its potential mechanism against diabetic complications in the model of metabolic syndrome have not yet been ch ...
DOI:
10.1016/j.phyplu.2021.100141

9. 4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection

Author:
Diego F. Vilas-Boas; Raphaela R.G. Oliveira; Elda Gonçalves-Santos; Luana S. Silva; Lívia F. Diniz; Ana L. Mazzeti; Guilherme A. Brancaglion; Diogo T. Carvalho; Sergio Caldas; Rômulo D. Novaes; Ivo S. Caldas
Source:
Acta tropica 2022 v.228 pp. 106314
ISSN:
0001-706X
Subject:
Trypanosoma cruzi; animal models; atrial natriuretic peptide; benznidazole; blood serum; coumarin; heart; hepatotoxicity; immunoglobulin G; inflammation; interleukin-10; interleukin-17; interleukin-2; interleukin-6; liver; metabolites; myocarditis; parasitemia; parasitism; survival rate; transaminases
Abstract:
... The anti-inflammatory and cardioprotective potential of coumarin metabolites in infectious myocarditis remains overlooked. Thus, the impact of the synthetic 4-nitrobenzoylcoumarin (4NB) alone and combined with benznidazole (Bz) in a murine model of Trypanosoma cruzi-induced acute myocarditis was investigated. Swiss mice infected with T. cruzi were randomized in 8 groups: uninfected, infected untre ...
DOI:
10.1016/j.actatropica.2022.106314

10. 5/6 nephrectomy affects enteric glial cells and promotes impaired antioxidant defense in the colonic neuromuscular layer

Author:
Patricia Pereira Almeida; Beatriz Bastos de Moraes Thomasi; Ágatha Cristie Menezes; Beatriz Oliveira Da Cruz; Nathalia da Silva Costa; Michele Lima Brito; Aline D'Avila Pereira; Cecília Ribeiro Castañon; Viviane Alexandre Nunes Degani; D'Angelo Carlo Magliano; Claude Knauf; Ana Lúcia Tavares-Gomes; Milena Barcza Stockler-Pinto
Source:
Life sciences 2022 v.298 pp. 120494
ISSN:
0024-3205
Subject:
animal models; antioxidant activity; antioxidants; colon; digestive tract; fibrosis; glutathione peroxidase; histopathology; inflammation; intestinal microorganisms; kidney diseases; kidneys; morphometry; oxidative stress; permeability; protein synthesis; superoxide dismutase; transcription factor NF-kappa B
Abstract:
... Chronic kidney disease (CKD) produces multiple repercussions in the gastrointestinal tract (GIT), such as alterations in motility, gut microbiota, intestinal permeability, and increased oxidative stress. However, despite enteric glial cells (EGC) having important neural and immune features in GIT physiology, their function in CKD remains unknown. The present study investigates colonic glial marker ...
DOI:
10.1016/j.lfs.2022.120494

11. A Functional Orange Juice Fortified with Beetroot By-Products Attenuates Hyperlipidemia and Obesity Induced by A High-Fat Diet

Author:
Eman M. Abdo; Omayma El-Sayed Shaltout; Salim Ali; Hanem M. M. Mansour
Source:
Antioxidants 2022 v.11 no.3 pp. -
ISSN:
2076-3921
Subject:
animal models; antioxidant activity; beets; betalains; beverages; catalase; flavonoids; glutathione peroxidase; high fat diet; hyperlipidemia; leaves; lifestyle; lipid composition; liver; nutritive value; obesity; orange juice; oxidative stress; titratable acidity
Abstract:
... Obesity is one of the most prevalent non-communicable diseases and is interlinked with incidences of various diseases. By modulating lifestyle and food quality, obesity can be preventable. The present study investigated the ability of a novel functional beverage based on orange juice and beetroot leaf and stem juice in preventing obesity-associated health issues. To achieve this purpose, we determ ...
DOI:
10.3390/antiox11030457

12. A biphasic material combined with injectable platelet-rich fibrin for the potential regeneration of oral soft and hard tissues

Author:
Shiqi Li; Qiang Xie; Anchun Mo
Source:
Journal of materials science 2022 v.57 no.16 pp. 7923-7940
ISSN:
0022-2461
Subject:
animal models; atrophy; biocompatibility; blood; bone formation; bone resorption; fibrin; palate; therapeutics; tissue repair; tissues
Abstract:
... The irreversible bone resorption accompanied by atrophy and reconstruction of soft tissue around the tooth loss site is still a challenging problem for implant therapy. The present study describes biphasic materials composed of fish-collagen/poly (lactide-co-glycolide) electrospun membranes and nano-hydroxyapatite/poly (lactide-co-glycolide) scaffolds for the regeneration of oral hard and soft tis ...
DOI:
10.1007/s10853-022-07163-2

13. A comparative investigation of toxicity of three polymer nanoparticles on acorn barnacle (Amphibalanus amphitrite)

Author:
Yong Jie Yip; Serina Siew Chen Lee; Mei Lin Neo; Serena Lay-Ming Teo; Suresh Valiyaveettil
Source:
Science of the total environment 2022 v.806 pp. 150965
ISSN:
0048-9697
Subject:
Balanus amphitrite; animal models; environment; luminescence; molecular weight; mortality; nauplii; pollution; poly(vinyl chloride); polymethylmethacrylate; polystyrenes; toxicity; wastes
Abstract:
... Pollution from plastic waste is increasingly prevalent in the environment and beginning to generate significant adverse impact on the health of living organisms. In this study, we investigate the toxicity of polymer nanoparticles exposed to Acorn Barnacle (Amphibalanus amphitrite) nauplii, as an animal model. Highly stable aqueous dispersion of luminescent nanoparticles from three common polymers: ...
DOI:
10.1016/j.scitotenv.2021.150965

14. A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

Author:
Noémie Alphonse; Joseph J. Wanford; Andrew A. Voak; Jack Gay; Shayla Venkhaya; Owen Burroughs; Sanjana Mathew; Truelian Lee; Sasha L. Evans; Weiting Zhao; Kyle Frowde; Abrar Alrehaili; Ruth E. Dickenson; Mads Munk; Svetlana Panina; Ishraque F. Mahmood; Miriam Llorian; Megan L. Stanifer; Steeve Boulant; Martin W. Berchtold; Julien R.C. Bergeron; Andreas Wack; Cammie F. Lesser; Charlotte Odendall
Source:
Cell 2022 pp. -
ISSN:
0092-8674
Subject:
Shigella; animal models; calcium; calcium-calmodulin-dependent protein kinase; calmodulin; cell death; epithelium; interferons; pathogenesis; phenotype; virulence
Abstract:
... Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains unclear. Here, we demonstrate that the Shigella OspC family of type-III-secreted effectors blocks IFN signaling independently of its cell death inhibitory activity. Rather, IFN inhibition was mediated by the binding of ...
DOI:
10.1016/j.cell.2022.04.028

15. A functional polysaccharide from Eriobotrya japonica relieves myocardial ischemia injury via anti-oxidative and anti-inflammatory effects

Author:
Xiaoli Huang; Ranran Hou; Wei Pan; Dingtao Wu; Wenwen Zhao; Qiu Li
Source:
Food & function 2022 v.13 no.1 pp. 113-120
ISSN:
2042-650X
Subject:
Eriobotrya japonica; animal models; drugs; infarction; interleukin-6; leaves; myocardial contraction; myocardial ischemia; myocardium; nephrotoxicity; polysaccharides; protective effect; reperfusion injury
Abstract:
... We herein report a food-derived polysaccharide (EJP) with the effect of relieving myocardial ischemia reperfusion injury (MIRI). This novel polysaccharide was isolated from the leaf of Eriobotrya japonica, and we first found its myocardium protective effects in vitro. Then, we firstly characterized EJP with a series of analytical technologies and further tested its effect on myocardial ischemia re ...
DOI:
10.1039/d1fo03208a

16. A hydrogen-bonded antibacterial curdlan-tannic acid hydrogel with an antioxidant and hemostatic function for wound healing

Author:
Zongbao Zhou; Jiangwei Xiao; Shuwen Guan; Zhijie Geng; Ruifang Zhao; Botao Gao
Source:
Carbohydrate polymers 2022 v.285 pp. 119235
ISSN:
0144-8617
Subject:
animal models; antioxidants; blood; carbohydrates; cytotoxicity; fibroblasts; hemolysis; hemostasis; hydrogels; hydrogen bonding; porosity; rheology; tannins
Abstract:
... Manufacturing facile and low-cost wound dressings that simultaneously meet the needs of the entire repair process remains the major challenge of effective wound healing. Herein, a series of curdlan-tannic acid hybrid hydrogels were successfully fabricated through the annealing technique. Notedly, when the mixing weigh ratio was 1:1, the hydrogel exhibited excellent physicochemical properties, incl ...
DOI:
10.1016/j.carbpol.2022.119235

17. A method for intracerebroventricular cannulation of young broiler chicks

Author:
Chris Lamberigts; Zhigang Song; Johan Buyse
Source:
MethodsX 2022 v.9 pp. 101724
ISSN:
2215-0161
Subject:
animal models; cannulas; cement; feed intake; hypothalamus; metabolism; methylmethacrylate; mortality; rodents; skull; surgery
Abstract:
... The site-specific administration of neuroactive substances or pharmacological agents is a routine practice in neurological studies. To facilitate chronic treatments intercranial cannulae are often implanted in the skull. These surgical procedures are widely described and well-documented for rodents, as the most common animal model, and even refined over the years. However, precise descriptions of ...
DOI:
10.1016/j.mex.2022.101724

18. A mixture of Panax ginseng and Scrophularia buergeriana improves immune function in an immunosuppressed murine model

Author:
Na-Ra Han; Kyeoung-Cheol Kim; Ju-Sung Kim; Seong-Gyu Ko; Hi-Joon Park; Phil-Dong Moon
Source:
Phytomedicine 2022 v.99 pp. 153984
ISSN:
0944-7113
Subject:
Panax ginseng; Scrophularia buergeriana; active ingredients; animal models; cytokines; fluorescent antibody technique; immune response; immunostimulants; inducible nitric oxide synthase; mice; nitrites; p-coumaric acid; phagocytosis; quantitative polymerase chain reaction; spleen; splenocytes; transcription factor NF-kappa B
Abstract:
... Immunomodulatory drugs are currently used for immunosuppressed individuals, but adverse side effects have been reported. Although Panax ginseng and Scrophularia buergeriana are known to have respective pharmacological properties, the potential of a mixture of Panax ginseng and Scrophularia buergeriana (Isam-Tang, IST) as an immunomodulatory drug has not yet been studied. The present study was desi ...
DOI:
10.1016/j.phymed.2022.153984

19. A morphometric analysis of thoracolumbar vertebrae in goat by computed tomography.

Author:
Josephine Roels; Roy Hassoun; M Massenzio; S Ronel; Y Lafon; Eric Viguier; Thibaut Cachon
Source:
Veterinary and Animal Science 2022 v.15 pp. 100233
ISSN:
2451-943X
Subject:
adults; animal models; animal science; computed tomography; computer software; goats; humans; intervertebral disks; lumbar spine; medicine; morphometry; scanners; thoracic spine
Abstract:
... The goat spine is widely used as an animal model for preclinical research in human medicine to test new spinal implants and surgical procedures. Therefore, precise morphometric data are needed. This study aims to provide morphometric data of the goat thoracolumbar vertebrae and to define the parameters/characteristics of the optimum implantation corridors for pedicle screws in the thoracolumbar sp ...
DOI:
10.1016/j.vas.2022.100233

20. A novel morphological index applied to genetic improvement of body shape in grass carp Ctenopharyngodon idella

Author:
Peng Jiang; Shengjie Li; Jiajia Fan; Jinxing Du; Dongmei Ma; Caixia Lei
Source:
Aquaculture 2022 v.548 pp. 737687
ISSN:
0044-8486
Subject:
Ctenopharyngodon idella; animal models; aquaculture; body weight; condition factor; consumer acceptance; farmers; fish; genetic improvement; heritability; path analysis; peduncle; phenotype; profitability; selection intensity
Abstract:
... Body shape is an economically important trait in grass carp (Ctenopharyngodon idella) that directly influences consumer acceptance and farmer profitability. It is essential to incorporate shape traits into the ongoing breeding program, as this would be expected to achieve rapid growth and maintain a slender shape for cultured populations. Thus, the aim of this study was to explore a suitable morph ...
DOI:
10.1016/j.aquaculture.2021.737687