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- Knight, Tanya J., et al. Show all 12 Authors
- Metabolic engineering 2020 v.57 pp. 203-216
- Chinese hamsters; animal ovaries; biological models; biopharmaceuticals; biosynthesis; catalytic activity; cell engineering; endoplasmic reticulum; gene overexpression; genes; genetic engineering; lipid composition; lipid metabolism; monoclonal antibodies; monounsaturated fatty acids; phenotype; post-translational modification; product quality; protein products; recombinant proteins; saturated fatty acids; stearoyl-CoA desaturase; sterols; transactivators
- ... Chinese hamster ovary (CHO) cell expression systems have been exquisitely developed for the production of recombinant biotherapeutics (e.g. standard monoclonal antibodies, mAbs) and are able to generate efficacious, multi-domain proteins with human-like post translational modifications at high concentration with appropriate product quality attributes. However, there remains a need for development ...
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- Eble, Tanya, et al. Show all 8 Authors
- Gene 2012 v.499 no.1 pp. 209-212
- ancestry; animal ovaries; atrophy; case studies; cataract; genetic techniques and protocols; heterozygosity; muscles; mutation; patients; phenotype; puberty; urine; women
- ... Mutations in POLG account for one of the most frequent nuclear encoded causes of mitochondrial disorders to date. Individuals harboring POLG mutations exhibit fairly heterogeneous clinical presentations leading to increasing difficulties in classifying these patients into defined clinical phenotypes. This study aims to investigate the molecular basis of a mitochondrial cytopathy in a patient with ...