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- Materne, Eva-Maria, et al. Show all 10 Authors
- Journal of biotechnology 2015 v.205 pp. 36-46
- animal tests; apoptosis; clinical trials; coculture; drug toxicity; drugs; fluorescent antibody technique; glucose; humans; laboratory animals; lactate dehydrogenase; lactic acid; liver; neurons; neurotoxicity; phenotype; phylogeny; quantitative polymerase chain reaction; staining; tissues; viability
- ... Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, often do not accurately predict drug toxicity, leading to high attrition rates in clinical studies (Paul et al., 2010). The phylogenetic distance between humans and laboratory animals is enormous, this affects the transferability of animal data on the effica ...