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You searched for: Subject term anti-inflammatory activity Remove constraint Subject term: anti-inflammatory activity Subject term X-ray diffraction Remove constraint Subject term: X-ray diffraction Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. A Major Diplotaxis harra-Derived Bioflavonoid Glycoside as a Protective Agent against Chemically Induced Neurotoxicity and Parkinson’s Models; In Silico Target Prediction; and Biphasic HPTLC-Based Quantification

Author:
Atallah F. Ahmed; Zhi-Hong Wen; Ahmed H. Bakheit; Omer A. Basudan; Hazem A. Ghabbour; Abdullah Al-Ahmari; Chien-Wei Feng
Source:
Plants 2022 v.11 no.5 pp. -
ISSN:
2223-7747
Subject:
Danio rerio; Diplotaxis harra; X-ray diffraction; acetylcholinesterase; amine oxidase (flavin-containing); anti-inflammatory activity; biomarkers; computer simulation; dexamethasone; free radicals; glycosides; humans; inducible nitric oxide synthase; inflammation; isorhamnetin; lipopolysaccharides; macrophages; models; neurotoxicity; oxidative stress; prediction; prostaglandin synthase; rheumatoid arthritis; therapeutics
Abstract:
... Oxidative stress and chronic inflammation have a role in developing neurodegenerative diseases such as Parkinson’s disease (PD) and inflammatory movement disorders such as rheumatoid arthritis that affect millions of populations. In searching for antioxidant and anti-inflammatory molecules from natural sources that can counteract neurodegenerative diseases and arthritis, the flavonoid-rich extract ...
DOI:
10.3390/plants11050648

2. A/ D-rings-seco limonoids from the fruits of Aglaia edulis and their bioactivities

Author:
Yujin Sun; Letian Cui; Yunpeng Sun; Qiurong Li; Yongyi Li; Zefan Wang; Wenjun Xu; Lingyi Kong; Jun Luo
Source:
Phytochemistry 2022 v.195 pp. 113049
ISSN:
0031-9422
Subject:
Aglaia; X-ray diffraction; anti-inflammatory activity; biological assessment; cytotoxicity; limonoids; moieties; multiple drug resistance; optical isomerism; plant biochemistry
Abstract:
... Agledulines A-K, eleven previously undescribed limonoids, including eight biogenic A/D-rings-seco limonoid analogs (agledulines A-H), one D-ring-seco limonoid (agleduline I) and two A-ring-seco limonoids with a rare Δ⁴,²⁸ moiety (agledulines J-K), together with twelve reported limonoids, were isolated from the fruits of Aglaia edulis. Their structures were determined by NMR data, HRESIMS, X-ray di ...
DOI:
10.1016/j.phytochem.2021.113049

3. Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect

Author:
Bin Li; Yi Hu; Ting Wu; Ying Feng; Cuiping Jiang; Hongzhi Du; Shan Lu
Source:
Food chemistry 2022 v.373 pp. 131485
ISSN:
0308-8146
Subject:
X-ray diffraction; anti-inflammatory activity; apigenin; bioavailability; food chemistry; functional foods; hydrogen; hydrophobicity; ingredients; molecular dynamics; pharmacokinetics; spectroscopy; thermal analysis; water solubility
Abstract:
... Apigenin (APG) is a functional ingredient in many foods, but its poor water solubility results in low bioavailability. This study aimed at delivering APG and improving bioavailability by a food-friendly co-amorphous formulation of APG with oxymatrine (OMT). After preparation of co-amorphous mixture (CM), characterized by powder x-ray diffraction and thermal analysis. Then, the presence of hydrogen ...
DOI:
10.1016/j.foodchem.2021.131485

4. Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity

Author:
Achara Raksat; Siwattra Choodej; Thammarat Aree; Samad Nejad Ebrahimi; Khanitha Pudhom
Source:
Phytochemistry 2022 v.196 pp. 113074
ISSN:
0031-9422
Subject:
Pterolobium; X-ray diffraction; anti-inflammatory activity; diterpenoids; lipopolysaccharides; macrophages; nitric oxide; plant biochemistry
Abstract:
... Eight undescribed cassane diterpenes, pterolobirins C−J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds ...
DOI:
10.1016/j.phytochem.2021.113074

5. Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity

Author:
Ying-Yao Li; Ying Yang; Mao Sun; Qing-Yun Lu; Xue-Xue Pu; Xiaoqian Ran; Dong-Mei Li; Jia-Jia Wan; Jian-Yi Huang; Shi-Peng Guan; Rongcan Luo; Yuan-Yuan Cheng; Ying-Tong Di; Xiao-Jiang Hao
Source:
Phytochemistry letters 2022 v.49 pp. 114-119
ISSN:
1874-3900
Subject:
Euphorbia peplus; X-ray diffraction; anti-inflammatory activity; macrophages; plant biochemistry; spectral analysis
Abstract:
... Three new jatrophane polyesters, Euphopepluanones M-O (1–3), along with eight known ones (4-11), were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were established based on extensive spectroscopic analysis. The absolute configurations of compound 1 were assigned by X-ray crystallographic analysis. In addition, their anti-inflammatory effects on lipopolysaccharide-in ...
DOI:
10.1016/j.phytol.2022.03.017

6. Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722

Author:
Senhua Chen; Heng Guo; Minghua Jiang; Qilin Wu; Jing Li; Hongjie Shen; Lan Liu
Source:
Marine drugs 2022 v.20 no.1 pp. -
ISSN:
1660-3397
Subject:
Diaporthe; X-ray diffraction; anti-inflammatory activity; cytotoxicity; fungi; mass spectrometry; xanthones
Abstract:
... Seven new xanthones, diaporthones A−G (1−7), together with 13 known analogues, including five mono- (8−14) and six dimeric xanthones (15−20), were obtained from the ascidian-derived fungus Diaporthe sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HR-ESIMS). The absolute configurations of 1 ...
DOI:
10.3390/md20010051

7. New ent-kaurane diterpenoid acids from Nouelia insignis Franch and their anti-inflammatory activity

Author:
Zhi-li Wu; Jia-yu Li; Peng-li Huang; Ze-shi Sun; Hui-liang Li; Wei-dong Zhang
Source:
RSC advances 2022 v.12 no.18 pp. 11155-11163
ISSN:
2046-2069
Subject:
X-ray diffraction; anti-inflammatory activity; circular dichroism spectroscopy; diterpenoids; dose response; interleukin-6; lipopolysaccharides; protein synthesis; spectral analysis
Abstract:
... Eleven undescribed ent-kaurane-type diterpenoid acids, namely noueinsiancins A–K (1–11), together with sixteen related known analogs (12–27) were isolated from Nouelia insignis Franch. The chemical structures and absolute configurations of the new compounds were confirmed by the extensive spectroscopic data, electronic circular dichroism (ECD) data analysis and single crystal X-ray diffraction. Ad ...
DOI:
10.1039/d2ra01684b

8. Sesquiterpene lactones from Artemisia mongolica

Author:
Ziwei Zhu; Ablajan Turak; Haji Akber Aisa
Source:
Phytochemistry 2022 v.199 pp. 113158
ISSN:
0031-9422
Subject:
Artemisia; X-ray diffraction; anti-inflammatory activity; antineoplastic activity; circular dichroism spectroscopy; crystal structure; plant biochemistry; sesquiterpenoid lactones
Abstract:
... Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), ...
DOI:
10.1016/j.phytochem.2022.113158

9. Solid lipid nanoparticles as an effective sodium aescinate delivery system: formulation and anti-inflammatory activity

Author:
Jinyue Wang; Hongyue Wang; Hongjia Xu; Jinghan Li; Xu Zhang; Xiangrong Zhang
Source:
RSC advances 2022 v.12 no.11 pp. 6583-6591
ISSN:
2046-2069
Subject:
X-ray diffraction; anti-inflammatory activity; drugs; ears; edema; emulsifying; encapsulation; experimental design; lipids; medicine; particle size; sodium; ultrasonic treatment
Abstract:
... Sodium aescinate-loaded solid lipid nanoparticles were fabricated using a melt-emulsification and ultrasonication method. Based on mean particle size, polydispersity index, and encapsulation efficiency, orthogonal and Box–Behnken designs were applied to optimize solid lipid nanoparticles with single emulsification and double emulsification methods. The characterization of solid lipid nanoparticles ...
DOI:
10.1039/d1ra07638h

10. Ximaoornatins A–C, Polyoxygenated Diterpenoids from the Hainan Soft Coral Sinularia ornata

Author:
Li-Li Sun; Xu-Wen Li; Yue-Wei Guo
Source:
Marine drugs 2022 v.20 no.3 pp. -
ISSN:
1660-3397
Subject:
Sinularia; X-ray diffraction; anti-inflammatory activity; bioassays; biosynthesis; corals; diterpenoids; macrophages; spectral analysis; South China Sea
Abstract:
... Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A–C (1–3), one new eunicellin-type diterpene, litophynin K (4), and a related known compound, litophynol B (5) were isolated from the South China Sea soft coral Sinularia ornata. The structures and absolute configurations of 1–4 were established by extensive ...
DOI:
10.3390/md20030218

11. (+)-/(−)-Prunomarin A and (+)-pestalactone B, three new isocoumarin derivatives from the endophytic fungus Phomopsis prunorum

Author:
Xue-Qing Zhang; Zhen-Hong Lu; Gui-Ru Xia; Wen-Min Song; Zhi-Yong Guo; Peter Proksch
Source:
Tetrahedron letters 2021 v.75 pp. 153205
ISSN:
0040-4039
Subject:
Amaranthus retroflexus; Diaporthe; X-ray diffraction; anti-inflammatory activity; enantiomers; endophytes; fungi; phytotoxicity; spectral analysis
Abstract:
... Three pairs of isocoumarin enantiomers, (±)-prunomarin A (1), (±)-pestalactone B (2), and (±)-3, including three new compounds, (+)-/(−)-1 and (+)-2, were isolated from the endophytic fungus Phomopsis prunorum (F4-3). These enantiomeric pairs were existed as partial racemates and were achieved by chiral-HPLC separation. Their structures were elucidated by comprehensive spectroscopic data, X-ray di ...
DOI:
10.1016/j.tetlet.2021.153205

12. (-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model

Author:
Afsana Tajmim; Areli K. Cuevas-Ocampo; Abu Bakar Siddique; Mohammed H. Qusa; Judy Ann King; Khaldoun S. Abdelwahed; Jafrin Jobayer Sonju; Khalid A. El Sayed
Source:
Nutrients 2021 v.13 no.5 pp. -
ISSN:
2072-6643
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; amyloid; anti-inflammatory activity; brain; complement; dietary supplements; dosage forms; erythritol; extra-virgin olive oil; females; ibuprofen; memory; mice; neurodegenerative diseases; pathogenesis; phosphorylation; taste
Abstract:
... Alzheimer’s disease (AD) is a complex progressive neurodegenerative disorder affecting humans mainly through the deposition of Aβ-amyloid (Aβ) fibrils and accumulation of neurofibrillary tangles in the brain. Currently available AD treatments only exhibit symptomatic relief but do not generally intervene with the amyloid and tau pathologies. The extra-virgin olive oil (EVOO) monophenolic secoirido ...
DOI:
10.3390/nu13051702

13. Aglatestine A, a Rearranged Limonoid with a 3/6/6 Tricarbocyclic Framework from the Fruits of Aglaia edulis

Author:
Yujin Sun; Yong Yin; Yunpeng Sun; Qiurong Li; Letian Cui; Wenjun Xu; Lingyi Kong; Jun Luo
Source:
Journal of organic chemistry 2021 v.86 no.16 pp. 11263-11268
ISSN:
1520-6904
Subject:
Aglaia; Lewis acids; X-ray diffraction; acetolysis; anti-inflammatory activity; biological assessment; circular dichroism spectroscopy; crystallography; macrophages; organic chemistry; quantum mechanics
Abstract:
... Aglatestine A (1), an unprecedented 3/6/6 tricarbocyclic limonoid framework along with four biogenic A/D-seco limonoid analogues with rare β-substituents at C-6 (2–5), was discovered from the fruits of Aglaia edulis. The structures of 1–5 along with their absolute configurations were clarified using methods of HRMS(ESI), NMR, electronic circular dichroism, X-ray diffraction crystallography, and qu ...
DOI:
10.1021/acs.joc.1c00968

14. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone

Author:
Olga Morarescu; Marina Grinco; Veaceslav Kulciţki; Sergiu Shova; Nicon Ungur
Source:
Marine drugs 2021 v.19 no.11 pp. -
ISSN:
1660-3397
Subject:
X-ray diffraction; anti-inflammatory activity; antifeedants; antiretroviral agents; condensation reactions; cytotoxicity; nerve growth factor; stereochemistry; synthesis
Abstract:
... Scalarane sesterterpenoids emerged as interesting bioactive natural products which were isolated extensively from marine sponges and shell-less mollusks. Some representatives were also reported recently from superior plants. Many scalarane sesterterpenoids displayed a wide spectrum of valuable properties, such as antifeedant, antimicrobial, antifungal, antitubercular, antitumor, anti-HIV propertie ...
DOI:
10.3390/md19110636

15. Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers

Author:
Xin Zhou; Wenjun Xu; Yiran Li; Meihui Zhang; Pengfei Tang; Weijia Lu; Qiji Li; Hao Zhang; Jun Luo; Lingyi Kong
Source:
Journal of agricultural and food chemistry 2021 v.69 no.2 pp. 646-654
ISSN:
1520-5118
Subject:
Hypericum; X-ray diffraction; antioxidants; circular dichroism spectroscopy; food chemistry; health services; meroterpenoids; methylation; spectral analysis
Abstract:
... In this work, 26 methylated acylphloroglucinol meroterpenoids with diverse skeletons, including 18 new ones (bellumones A-R, 1–18), were identified from the flowers of Hypericum bellum. Their structures including absolute configurations were elucidated by detailed spectroscopic data, calculated electronic circular dichroism (ECD), and X-ray diffraction (XRD). Through methylation at C-5, prenylatio ...
DOI:
10.1021/acs.jafc.0c05417

16. Azaphilones and isocoumarin derivatives from Penicillum chermesinum FS625 isolated from the South China Sea

Author:
Jie Zhang; Yuchan Chen; Zhaoming Liu; Saini Li; Jinqian Zhong; Bohong Guo; Hongxin Liu; Weimin Zhang
Source:
Tetrahedron letters 2021 v.73 pp. 153117
ISSN:
0040-4039
Subject:
Penicillium; X-ray diffraction; anti-inflammatory activity; biosynthesis; circular dichroism spectroscopy; cytotoxicity; fungi; macrophages; nitric oxide; spectral analysis; South China Sea
Abstract:
... Five previously undescribed compounds, including four azaphilones chermesinones D-G (1–4), one new isocoumarin derivative 6,8-dihydroxy-3-methoxy-3,7-dimethylisochroman-1-one (8), together with four known compounds were isolated from the marine-derived fungus Penicillium chermesinum FS625. Their structures were well established by comprehensive spectroscopic analysis. The absolute configurations o ...
DOI:
10.1016/j.tetlet.2021.153117

17. Benzofuran ε-caprolactam glucosides, amides and phenylpropanoid derivatives with anti-inflammatory activity from Oxybaphus himalaicus

Author:
Yan Qiu; Xuedong Yang; Jun Xu; Bo Liu; Xiaoxue Li
Source:
Phytochemistry 2021 v.191 pp. 112905
ISSN:
0031-9422
Subject:
Mirabilis himalaica var. himalaica; X-ray diffraction; anti-inflammatory activity; glucosides; interleukin-6; lignans; medicinal plants; models; plant biochemistry; sucrose
Abstract:
... (+)-(2S,3S)- and (−)-(2R,3R)-Oxybaphuslactam A glucosides are two undescribed benzofuran ε-caprolactams featuring a unique 7/6/5 fused tricyclic framework with p-glucosyl-O-phenyl unit. They were isolated from the root of Tibetan medicinal plant Oxybaphus himalaicus along with an undescribed sucrose ester, 3-O-feruloyl sucrose, an undescribed lignan glucoside, (7′R,8R,8′S)-3,3′,5,5′-tetramethoxy-7 ...
DOI:
10.1016/j.phytochem.2021.112905

18. Bioactive terpenoids from Croton laui

Author:
Fei Li; Dong-Bo Zhang; Jing-Tao Li; Feng-Jie He; Hong-Li Zhu; Nan Li; Xin-Chun Xiao; Li Ren; Wei Zheng
Source:
Natural product research 2021 v.35 no.17 pp. 2849-2857
ISSN:
1478-6427
Subject:
Croton; X-ray diffraction; circular dichroism spectroscopy; diterpenoids; human cell lines; lipopolysaccharides; macrophages; nitric oxide; research; triterpenoids
Abstract:
... Two new highly-oxygenated neo-clerodane diterpenoids, 3S-acetoxyl-mollotucin D dilactone ester (1) and 6S-crotoeurin C (2), and a new lupane-type triterpene, 16β-hydroxyl-3β-O-trans-coumaroyl-betulin (6), as well as three known analogues (3–5) were obtained from the leaves of Croton laui. The structures of the new compounds were determined by extensive spectroscopic methods, and their absolute con ...
DOI:
10.1080/14786419.2019.1675062

19. Chemical constituents from salt lake-derived Streptomyces sp. QHA10

Author:
Hao-Wen Zhao; Jia-Qi Li; Wan-Jing Ding
Source:
Journal of Asian natural products research 2021 v.23 no.1 pp. 26-32
ISSN:
1477-2213
Subject:
Streptomyces; X-ray diffraction; anti-inflammatory activity; lipopolysaccharides; liquid state fermentation; macrophages; mice; nitric oxide; research; salt lakes; spectral analysis
Abstract:
... Two new alkaloids (1,2) and one new enoic acid (3), together with three known piericidins (4-6), were isolated from the liquid fermentation of the salt lake derived Streptomyces sp. QHA10. The structures of 1-3 were elucidated based on extensive spectroscopic data (NMR, HRESIMS) as well as single-crystal X-ray diffraction. Compound 3 showed potential anti-inflammatory activity by inhibiting the pr ...
DOI:
10.1080/10286020.2019.1700230

20. Diisoprenyl-cyclohexene/ane-Type Meroterpenoids from Biscogniauxia sp. and Their Anti-inflammatory Activities

Author:
Huan Zhao; Jian Zou; Wei Xu; Dan Hu; Liang-Dong Guo; Jia-Xu Chen; Guo-Dong Chen; Kwok-Fai So; Xin-Sheng Yao; Hao Gao
Source:
Journal of organic chemistry 2021 v.86 no.16 pp. 11177-11188
ISSN:
1520-6904
Subject:
X-ray diffraction; anti-inflammatory activity; carbonates; interleukin-6; meroterpenoids; organic chemistry; secondary metabolites; skeleton
Abstract:
... A secondary metabolites investigation on Biscogniauxia sp. 71-10-1-1 was carried out, which led to the obtention of nine new diisoprenyl-cyclohexene/ane-type meroterpenoids (1–9) and two new isoprenylbenzoic acid-type meroterpeniods (10–11). The structures of these isolates were established on the basis of multispectroscopic analyses, ECD, and ¹³C chemical shifts calculations, and single-crystal X ...
DOI:
10.1021/acs.joc.1c00369