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... Paddy soils are potential hotspots of combined contamination with arsenic (As) and antibiotics, which may induce co-selection of antibiotic resistance genes (ARGs) and As biotransformation genes (ABGs), resulting in dissemination of antimicrobial resistance and modification in As biogeochemical cycling. So far, little information is available for these co-selection processes and specific patterns ...
... This study demonstrates a novel multi-functional microfluidic system, designated three dimensional Alternative Current Electrokinetic/Surface Enhanced Raman Scattering (3D-ACEK/SERS), which can concentrate bacteria from whole blood, identify bacterial species, and determine antibiotic susceptibilities of the bacteria rapidly. The system consists of a hybrid electrokinetic mechanism, integrating AC ...
... Accurate determination of antibiotic resistance genes (ARGs) in environmental DNA molecules (eDNA) is challenging owing to its low abundance in the aquatic environment. Here we report a facile and cost-efficient approach to extract trace amount of eDNAs in the aquatic environment using LnPO₄ nanomaterials. Among the nanomaterials, less crystalline TbPO₄ nanoneedles was identified as the most promi ...
Enterococcus; Escherichia coli; One Health initiative; aminoglycosides; animal health; antibiotic resistance; antibiotic resistance genes; game animals; humans; indicator species; livestock; metagenomics; microbiome; monitoring; omnivores; phenotype; pollution; wild boars; wildlife; Europe
Abstract:
... Antimicrobial resistance (AMR) is a serious problem for public and animal health, and also for the environment. Monitoring and reporting the occurrence of AMR determinants and bacteria with the potential to disseminate is a priority for health surveillance programs around the world and critical to the One Health concept. Wildlife is a reservoir of AMR, and human activities can strongly influence t ...
anaerobic digestion; antibiotic resistance; feedstocks; humans; land application; metabolism; organic wastes; public health
Abstract:
... The overuse and inappropriate disposal of antibiotics raised severe public health risks worldwide. Specifically, the incomplete antibiotics metabolism in human and animal bodies contributes to the significant release of antibiotics into the natural ecosystems and the proliferation of antibiotic-resistant bacteria carrying antibiotic-resistant genes. Moreover, the organic feedstocks used for anaero ...
... The emergence of antimicrobial resistance is one of the major challenges addressed by the aquaculture industry in recent years. Bacterial resistance to antibiotics is mainly due to the rampant prophylactic use of antibiotics in fish farms. The persistent nature of antibiotics in the system ultimately leads to the development of resistance in environmental bacteria; consequently, resistance can be ...
anaerobic digestion; antibiotic resistance; cattle; environment; meta-analysis; pH; swine; temperature
Abstract:
... Anaerobic digestion (AD) has shown the potential to reduce the numbers and types of antibiotic-resistance genes (ARG) present in animal manures. However, the variability of the results has limited the ability to draw solid conclusions. To address this issue, we performed a series of meta-analyses to evaluate how AD of pig, cattle, and dairy manures affects ARG levels and how different parameters, ...
Clostridium difficile; antibiotic resistance; ciprofloxacin; clindamycin; diarrhea; erythromycin; genomics; health services; levofloxacin; metronidazole; moxifloxacin; multilocus sequence typing; pathogens; probiotics; public health; vancomycin; China
Abstract:
... Clostridioides difficile is the predominant pathogen responsible for antimicrobial associated diarrhea (AAD) and health care facility-associated infectious diarrhea. The role of C. difficile in China and its impact on public health have gained attention in recent years. Most clinical C. difficile isolates in China belong to multilocus sequence type clade 1 with sequence types (STs) 3, 35 and 54 pr ...
... Antimicrobial resistance is one of the greatest global threats. Particularly, multidrug resistant extended-spectrum β-lactamase (ESBL)-producing pathogens confer resistance to many commonly used medically important antibiotics, especially beta-lactam antibiotics. Here, we developed an innovative combination approach to therapy for multidrug resistant pathogens by encapsulating cephalosporin antibi ...
... Human milk is a key source of promising probiotic lactic acid bacteria. The Enterococcus species, because of their dual commensal and pathogenic nature, demand critical safety analysis to establish them as probiotic candidates. In this study, eighteen E. faecalis strains from human milk of mothers living in Pakistan were typed at the strain level by riboprinting. The typed strains were then evalua ...
... Traditionally, urinary tract infections (UTIs) have been categorised as either uncomplicated or complicated in veterinary medicine, with treatment differing for the two categories. In human medicine, there is an additional category: Asymptomatic bacteriuria, which is the presence of bacteriuria without symptoms of infection. Escherichia coli (E.coli) is the most common bacterial species involved i ...
... Lectins are biologically versatile biomolecules with remarkable antimicrobial effects, notably against bacteria, fungi and protozoa, in addition to modulating host immunity. For this, the lectins bind to carbohydrates on the surface of the pathogen, which can cause damage to the cell wall and prevent the attachment of microorganisms to host cells. Thus, this study intends to review the biological ...
... Understanding the bacterial behavior in response to sublethal stresses is crucial for the optimization of antimicrobial treatments, particularly in food processing. However, the data regarding the effect of sublethal concentrations of essential oils (EOs) on microbial cells are still scarce. In this study, we evaluated the response of Listeria monocytogenes ATCC 7644 to the sublethal concentration ...
... Antibiotic-resistant Cutibacterium acnes and dysbiosis of the skin microbiome are of increasing concern in acne treatment. Enterococcus faecalis, a widely used probiotic, has shown benefits for acne treatment by exerting antimicrobial activity against C. acnes. Therefore, this study aimed to investigate the efficacy and safety of an E. faecalis CBT SL-5-extract-containing lotion in patients with m ...
Cervus dama; Cervus elaphus; Escherichia coli; Ovis aries; Sus scrofa; World Health Organization; ampicillin; antibiotic resistance; beta-lactamase; beta-lactamase bacteria; environmental health; humans; indicator species; mouflon; multiple drug resistance; plasmids; pollution; tetracycline; wild boars; wildlife; Portugal
Abstract:
... Extended-spectrum β-lactamases (ESBL)-producing Enterobacterales have been classified as critical priority pathogens by the World Health Organization (WHO). ESBL are universally distributed and, in 2006, were firstly reported on a wild animal. Understanding the relative contributions of wild animals to ESBL circulation in the environment is urgently needed. In this work, we have conducted a nation ...
... Escherichia coli (E. coli) are common bacteria that colonize the human and animal gastrointestinal tract, where they help maintain a balanced microbiome. However, some E. coli strains are pathogenic and can cause serious infectious diseases and life-threatening complications. Due to the overuse of antibiotics and limited development of novel antibiotics, the emergence of antibiotic-resistant strai ...
antibiotic resistance; bioinformatics; community structure; computer simulation; environmental DNA; health effects assessments; human health; land use; metagenomics; microbial communities; research; rivers; sediments; stream channels; water; New Jersey
Abstract:
... Human health risk assessment for environmental antibiotic resistant microbes requires not only quantifying the abundance of antibiotic resistance genes (ARGs) in environmental matrices, but also understanding their hosts and genetic context. Further, differentiating ARGs in intracellular and extracellular DNA (iDNA and eDNA) fractions may help refine our understanding of ARG transferability. The o ...
... Biochar has been used to alleviate the contamination of antibiotic resistance genes (ARGs) in soil and to inhibit ARGs transfer from soil to plants. However, the effect of aged biochar on ARGs abundance in soil and ARGs enrichment in plants are scarcely investigated. In this study, a pot experiment was conducted to compare the effects of fresh and aged biochars on the accumulation of five typical ...
... Sludge from wastewater treatment plants can act as a repository and crucial environmental provider of antibiotic resistance genes (ARGs). Over the past few years, people’s knowledge regarding the occurrence and removal of ARGs in sludge has broadened remarkably with advancements in molecular biological techniques. Anaerobic and aerobic digestion were found to effectively achieve sludge reduction a ...
Aeromonas; One Health initiative; antibiotic resistance; aquaculture; financial economics; human health; therapeutics
Abstract:
... Aeromonas is at the interface of all the One Health components and represents an amazingly sound test case in the One Health approach, from economic loss in aquaculture tochallenges related to antibiotic-resistant bacteria selected from the environment. In human health, infections following leech therapy is an outstanding example of such One Health challenges. Aeromonads are not only ubiquitous en ...
... The misuse of antimicrobials has caused a remarkable increase of antibiotic-resistant bacteria. Developing novel antimicrobial agents with high activity and low rates of resistance development is in great demand yet challenging. In this context, we developed a novel cascaded AgNPs/nGOx/Apra nanocomposite for combinational antimicrobial therapy. Glucose oxidase nanocapsules (nGOx) in the nanocompos ...
... Antibiotic compounds can enter the environment and eventually into drinking water, when manure containing non-metabolized antibiotic residues is applied to agricultural land. In this study, the publication data was analyzed from the aspects of countries, subject categories and keywords during the period of 1946–2016 from Web of Science. The results indicated that, during the period of 2004–2016, t ...
... In the last two years, COVID-19 pandemic caused by SARS-CoV-2 has created a mass destruction among humanity causing a major health crisis around the world. With the emergence of new strains of the virus, lack of targeted drugs and antimicrobial resistance, there is a dire need to discover specific antiviral with minimum side effects targeted against COVID-19. The present study evaluates the antivi ...
... Shigella flexneri is the main causative agent of the communicable diarrheal disease, shigellosis. It is estimated that about 80–165 million cases and > 1 million deaths occur every year due to this disease. S. flexneri causes dysentery mostly in young children, elderly and immunocompromised patients, all over the globe. Recently, due to the emergence of S. flexneri antibiotic resistance strains, i ...
... Antibiotic resistance genes (ARGs) in municipal drinking water may not be effectively removed during centralized treatment. To reduce potential health risks, water disinfection at the point-of-use scale is warranted. This study investigated the performance of boiling, a prevalent household water disinfection means, in response to ARGs contamination. We found that boiling was more efficient in inac ...
... Serious concerns have been raised regarding resistomes caused by corpse decomposition in the aquatic environment, which has posed threats to the water environment and human health. However, antibiotic resistance genes (ARGs) in large-volume tap water and their temporal stability during corpse decay are poorly explored. Here, high-throughput quantitative polymerase chain reaction (HT-qPCR) and ampl ...
... Citrus reticulata Blanco and Citrus aurantifolia are the edible plants which contain several biological properties including antibacterial activity. The aims of the present study were to determine the chemical compositions and evaluate antibacterial activities of citrus essential oils extracted from the fruit peels of C. reticulata (CREO) and C. aurantifolia (CAEO), alone and in combination with g ...
... BACKGROUND: The antibacterial activities of aqueous leaf extracts of Moringa oleifera, Vernonia amygdalina, Azadirachta indica and Acalypha wilkesiana against multidrug resistance (MDR) Staphylococcus aureus associated with skin and soft tissue infections were investigated. METHODS: Staphylococcus aureus (n = 183) from the skin and soft tissue infections with evidence of purulent pus, effusions fr ...
... AIMS: To investigate the antibacterial activity of three (palmarosa, basil and rosemary) essential oils (EOs) on Aeromonas veronii and Aeromonas caviae, and determine minimum inhibitory concentration (MIC) of potent EO against tetracycline and sulfonamide resistant strains. METHODS AND RESULTS: Palmarosa oil (PMO) showed significantly (p < 0.05) higher inhibition zones against both A. veronii and ...
... Knowing the antibiotic resistance profile of pathogenic bacteria is essential to finding an appropriate remedy for these issues by sourcing antibacterial agents from plants. The present study exposes the bactericidal potential of different leaf extracts of Blepharis maderaspatensis and Ziziphus oenoplia against multi drug resistant bacterial strains enumerated from pus specimens at a secondary car ...
... Listeria monocytogenes is a prominent foodborne pathogen with potent biofilm-forming capability, which is to be crucial for its antimicrobial resistance and persistence. Therefore, using a combination of preservative components (hurdle technology) to control biofilms is a promising strategy. The purpose of this study was to investigate the antibiofilm efficacy of nisin alone and combined with thym ...
... Although its importance, little information is available on antibiotic-resistance in cow-calf beef farms. This study aimed to determine prevalence and risk factors for antibiotic-resistant organisms in this livestock system. Fifty-four farms from Central Italy were included to assess the presence of antibiotic-resistant indicator Escherichia coli and of ESBL and/or AmpC-producing E. coli (ESBL/Amp ...
... Escherichia coli is considered the main cause of intestinal and extra-intestinal infections, they have virulence mechanisms in different pathotypes and the ability to receive or transmit antimicrobial resistance genes. The aim of this work was to investigate the antibacterial and antimicrobial modulating activity of α-pinene and borneol against E. coli and enteropathogenic (EPEC) and enterotoxigen ...
... The overuse of antibiotics and their disposal without processing are leading the environment and its inhabitants towards a serious health emergency. There is abundance of diverse antibiotic resistance genes and bacteria in environment, which demands immediate attention for the effective removal of antibiotics. There are physical and chemical methods for removal, but the generation of toxic byprodu ...
... Pig manure, rich in antibiotics and metals, is widely applied in paddy fields as a soil conditioner, triggering the proliferation of antibiotic resistance genes (ARGs) in soil. However, comprehensive studies on the effects of manure fertilization on the abundance of ARGs and their influencing factors are still insufficient. Here, pig manure and manure-amended and inorganic-amended soils were colle ...
... Antibiotic resistance in agricultural soils is a significant environmental and health challenge worldwide. To minimize the risk of antibiotic resistance, it is important to understand the fate and spread mechanism of antibiotics and antibiotic resistance genes (ARGs), and develop effective technologies to minimize their negative effects. In this work, we reviewed recent studies on the occurrence o ...
DNA; antibiotic resistance; digestive system; horizontal gene transfer; humans; intestinal microorganisms; mutation; public health
Abstract:
... Antibiotic-resistant infections are a major threat to global public health and there is an urgent need to develop new drugs and interventions to treat and prevent infections caused by antibiotic-resistant bacteria. The human gut microbiota harbours both commensals and opportunistic pathogens which can acquire resistance to antibiotics through mutation and horizontal gene transfer. The powerful com ...
Bifidobacterium; Lactobacillus; Lactococcus; Leuconostoc; Pediococcus; Streptococcus; Weissella; animal husbandry; antibiotic resistance; antibiotic resistance genes; chloramphenicol; dairy industry; food microbiology; gentamicin; kanamycin; lactic acid; process control; public health; raw milk; tetracycline
Abstract:
... Antibiotic Resistance is a growing concern for public health and global economy. Lactic acid bacteria (LAB) involved in the production of dairy products and commonly present in the agro-zootechnical environment can act as reservoirs of antibiotic resistance genes, acquiring or transferring them to other microorganisms. The review focuses on LAB group of dairy origin (Lactobacillus, Lactococcus, St ...
... BACKGROUND: In the past decade, Mycoplasma synoviae (M. synoviae) infection has become widely prevalent in China, has caused serious economic losses and has become one of the most important diseases in the chicken industry. Medication is a general approach for the control of M. synoviae infection, but antibiotics are sometimes ineffective in clinical practice. To investigate the sensitivity of M. ...
... Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish. A total of 99 isolates ...
antibiotic resistance; chemical oxygen demand; drainage; mined soils; nitrogen; risk; rivers; tetracycline; uranium; China
Abstract:
... Both heavy metals and radiation could affect the proliferation and dissemination of emerging antibiotic resistance pollutants. As an environmental medium rich in radioactive metals, the profile of antibiotic resistance in uranium mine remains largely unknown. A uranium mine in Guangdong province, China was selected to investigate the distribution and influencing factors of antibiotic-resistant bac ...
... Antibiotic resistance genes (ARGs) may lead to bacterial resistance and using antibiotics will promote ARGs spread. Large amounts of antibiotics were used in aquaculture, but little attention was paid to the antibiotic resistant in fish gut. In this study, nine kinds of Chinese freshwater and marine fish were acquired in a city of northern China to test the amount of antibiotics and ARGs residues ...
animal and human health; antibiotic resistance; antibiotics; aquaculture; aquatic environment; disease outbreaks; fish; fish consumption; gene transfer; muscles; pollution; research; shellfish; shrimp
Abstract:
... Aquaculture is remarkably one of the most promising industries among the food-producing industries in the world. Aquaculture production as well as fish consumption per capita have been dramatically increasing over the past two decades. Shifting of culture method from semi-intensive to intensive technique and applying of antibiotics to control the disease outbreak are the major factors for the incr ...
... Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therapies may offer a more targeted approach with less susceptibility to resistance. Even though antimicrobial peptides (AMPs) have been introduced as emerging antibiotic sources, they are not wide ...
Pseudomonas aeruginosa; World Health Organization; antibiotic resistance; antimicrobial peptides; cross infection; evolution; humans; lead; microbiome; multiple drug resistance; outer membrane proteins; probiotics; transporters
Abstract:
... The excess use of antibiotics has led to the evolution of multidrug-resistant pathogenic strains causing worldwide havoc. These multidrug-resistant strains require potent inhibitors. Pseudomonas aeruginosa is a lead cause of nosocomial infections and also feature in the critical priority list of the world health organization (WHO) for the development of new antibiotics against their antimicrobial ...
... The antimicrobial properties of Coriandrum sativum, Lactuca sativa, and Mentha spicata were examined using Kirby-Bauer disk diffusion technique. Among the solvents used for extraction, methanol, acetone, and n-hexane extracts were effective against antibiotic resistant microbes. The highest inhibition zone (17.0 ± 0.5 mm) was noted for the methanol extract of C. sativum against Bacillus cereus and ...
... Infections during pregnancy can culminate in adverse pregnancy outcomes, including preterm birth (PTB). Pakistan is among the top ten nations with high PTB-associated neonatal mortality rates, where access to prenatal as well as neonatal care is only afforded by the privileged few. Societal stigma further discourages women seeking healthcare for minor infections. Microbial pathogens associated wit ...
Nihal P. D. Bamunusinghage; Roshen G. Neelawala; Hasintha P. Magedara; Nuwanthi W. Ekanayaka; Ruwani S. Kalupahana; Ayona Silva-Fletcher; Sanda A. Kottawatta
Escherichia coli; anti-infective agents; antibiotic resistance; disk diffusion antimicrobial test; livestock; multiple drug resistance; public health; wildlife; Sri Lanka
Abstract:
... Antimicrobial resistance (AMR) is a major public health concern. We identified AMR in fecal Escherichia coli of wildlife (WL), urban wildlife (UWL), and livestock in the eastern region in Sri Lanka and compared the prevalence of AMR bacteria from carnivores, omnivores, and herbivores. Fecal samples were collected from 165 animals: WL (n=47), UWL (n=54), and livestock (n=64). Esherichia coli was cu ...
... Nontyphoidal-Salmonella bacteria cause foodborne gastroenteritis that may lead to fatal bacteremia, osteomyelitis, and meningitis if not treated properly. The emergence of multidrug-resistant Salmonella strains is a global public health threat. Regular monitoring of genotypes and phenotypes of Salmonella isolated from humans, animals, foods, and environments is mandatory for effective reduction an ...
... Actinomyces species play an important role in the pathogenesis of oral diseases and infections. Susceptibility testing is not always routinely performed, and one may oversee a shift in resistance patterns. The aim of the study was to analyze the antimicrobial susceptibility of 100 well-identified clinical oral isolates of Actinomyces spp. against eight selected antimicrobial agents using the agar ...