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- Smider, Vaughn V., et al. Show all 5 Authors
- Methods 2013 v.60 pp. 91-98
- antibodies; epitopes; immunization; ion channels
- ... Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this approach has led to many successful therapeutic antibodies, targets have been limited to proteins which are easily purified. In addition, selection driven discovery has produced a narrow range of antibody functionalities focused on high affinity ...