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You searched for: Author "Nakayasu, Chihaya" Remove constraint Author: "Nakayasu, Chihaya" Subject antigens Remove constraint Subject: antigens Subject protective effect Remove constraint Subject: protective effect
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1. Enhancement of piscine orthoreovirus-2 DNA vaccine potency by linkage of antigen gene to a trigger factor gene or signal peptide genes

Author:
Nakayasu, Chihaya,   et al.   ; Matsuyama, Tomomasa; Takano, Tomokazu; Honjo, Miho; Kikuta, Takumi; Nawata, Akatsuki; Kumagai, Akira; Honda, Ryo; Sakai, Takamitsu; Kurita, Jun; Terashima, Sachiko; Yamazaki, Masatoshi; Matsuura, Yuta; Nishizawa, Yuko;     Show all 14 Authors
Source:
Aquaculture 2021 v.533 pp. 736163
ISSN:
0044-8486
Subject:
Oncorhynchus kisutch; anemia; antibodies; antigens; antiserum; blood serum; cell lines; erythrocytes; etiological agents; fish; genes; genotype; inclusion bodies; muscles; necrosis; protective effect; recombinant vaccines; signal peptide; vaccination; vaccine development; viral growth; viral load; viral nonstructural proteins; virus replication; Japan
Abstract:
... Coho salmon (Oncorhynchus kisutch) is a Pacific salmon species that is commercially farmed in Japan, and is susceptible to erythrocyte inclusion body syndrome (EIBS), which is characterized by anemia, erythrocyte inclusion bodies, and cardiovascular muscle necrosis. At present, no vaccine for this disease is available. Piscine orthoreovirus-2 (PRV-2) is the causative agent of EIBS in Japan, and is ...
DOI:
10.1016/j.aquaculture.2020.736163

2. Antibody profiling using a recombinant protein–based multiplex ELISA array accelerates recombinant vaccine development: Case study on red sea bream iridovirus as a reverse vaccinology model

Author:
Nakayasu, Chihaya,   et al.   ; Matsuyama, Tomomasa; Sano, Natsumi; Takano, Tomokazu; Sakai, Takamitsu; Yasuike, Motoshige; Fujiwara, Atushi; Kawato, Yasuhiko; Kurita, Jun; Yoshida, Kazunori; Shimada, Yukinori;     Show all 11 Authors
Source:
Vaccine 2018 v.36 no.19 pp. 2643-2649
ISSN:
0264-410X
Subject:
Infectious spleen and kidney necrosis virus; Seriola dumerili; Seriola quinqueradiata; antibodies; antigens; blood serum; case studies; enzyme-linked immunosorbent assay; fish; genes; immune response; models; pathogens; prediction; protective effect; recombinant vaccines; screening; sorbents; vaccine development
Abstract:
... Predicting antigens that would be protective is crucial for the development of recombinant vaccine using genome based vaccine development, also known as reverse vaccinology. High-throughput antigen screening is effective for identifying vaccine target genes, particularly for pathogens for which minimal antigenicity data exist. Using red sea bream iridovirus (RSIV) as a research model, we developed ...
DOI:
10.1016/j.vaccine.2018.03.059