Subject term: antineoplastic activity and Oriental traditional medicine

1. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

Author:: Junqian Zhang; Chunjie Li; Li Zhang; Yongqing Heng; Shiwen Wang; Yongfu Pan; Lili Cai; Yunjing Zhang; Tong Xu; Xihui Chen; Robert M Hoffman; Lijun Jia
Source:: Phytomedicine 2022 v.98 pp. 153933
ISSN:: 0944-7113
Subject:: Andrographis; DNA damage; Oriental traditional medicine; adenocarcinoma; andrographolide; anti-inflammatory agents; antineoplastic activity; cancer therapy; cell cycle checkpoints; cell proliferation; cell senescence; flow cytometry; humans; lung neoplasms; lungs; mice; neoplasm cells; protein content; xenotransplantation
Abstract:: ... Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) is a diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the potential to target senescence in recalcitrant lung cancer. To determine whether AD can induce senescence in ...
DOI:: 10.1016/j.phymed.2022.153933
: https://doi.org/10.1016/j.phymed.2022.153933

2. Anti-cancer, anti-bacterial and anti-oxidant properties of an active fraction isolated from Curcuma zedoaria rhizomes

Author:: Sharaf Shehna; S Sreelekshmi; PR Remani; G Padmaja; S Lakshmi
Source:: Phytomedicine plus 2022 v.2 no.1 pp. 100195
ISSN:: 2667-0313
Subject:: Curcuma zedoaria; Oriental traditional medicine; antimicrobial properties; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell cycle checkpoints; cyclophosphamide; longevity; lung neoplasms; lymphoma; phytochemicals; solvents; therapeutics; toxicity
Abstract:: ... Curcuma zedoaria is a plant with rich source of phytochemicals extensively used in ayurvedic and Chinese medicine to treat tumors and other ailments. Henceforth, this study was undertaken to scientifically validate the different solvent fractions and isolate active fraction from the plant for the study pertaining to different biological activities including cancer. The objectives of the study incl ...
DOI:: 10.1016/j.phyplu.2021.100195
: https://doi.org/10.1016/j.phyplu.2021.100195

3. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

Author:: Zhijun Li; Haiying Bao
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114898
ISSN:: 0378-8741
Subject:: Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
Abstract:: ... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
DOI:: 10.1016/j.jep.2021.114898
: https://doi.org/10.1016/j.jep.2021.114898

4. Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma

Author:: Yang Shen; Fan Yang; Haiyan Peng; Guangji Zhang; Fangfang Zhu; Haojun Xu; Le Shi
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114601
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; blood serum; cell growth; flow cytometry; hepatoma; mice; models; protein synthesis; xenotransplantation
Abstract:: ... Yanggan Huayu granule (YGHY) is a formula of traditional Chinese medicine that has been widely used to treat patients with liver cancer. But its working mechanism is still poorly understood.Aim of the study: To investigate the anti-tumor effect of YGHY and its working mechanisms in hepatocellular carcinoma (HCC).H22 mouse xenograft model was used to detect the effect of YGHY on hepatocellular carc ...
DOI:: 10.1016/j.jep.2021.114601
: https://doi.org/10.1016/j.jep.2021.114601

5. Anticancer activity of Alpinia purpurata (Vieill) K. Schum. against MNU and testosterone induced prostate cancer in male Wistar albino rats

Author:: Anusooriya Palanirajan; Poornima Kannappan; Gopalakrishnan Velliyur Kanniappan
Source:: Pharmacological research 2022 v.3 pp. 100105
ISSN:: 2667-1425
Subject:: Alpinia purpurata; Oriental traditional medicine; albino; anesthesia; antineoplastic activity; antineoplastic agents; antioxidants; blood serum; carcinoma; caudal vein; cervical dislocation; chloroform; ethyl acetate; herbal medicines; histopathology; ingredients; intraperitoneal injection; intravenous injection; kidneys; leaf extracts; leaves; lipids; liver; males; nucleic acids; propylene glycol; prostate gland; prostatic neoplasms; protein content; research; seminal vesicles; testosterone; toxicity
Abstract:: ... Numerous Chinese herbal extracts have been proved to inhibit the development of prostate cancer. Zingiberaceae family is one type of plant used as an ingredient in traditional Chinese medicine (TCM). The genus Alpinia species of the Zingiberaceae family are well-known traditional herbal medicine for anti-inflammatory, antioxidant, antimicrobial, anti-dermatophytic, anti-nociceptive, hepatoprotecti ...
DOI:: 10.1016/j.prmcm.2022.100105
: https://doi.org/10.1016/j.prmcm.2022.100105

6. Anticancer activity of an Artemisia annua L. hydroalcoholic extract on canine osteosarcoma cell lines

Author:: Roberta Salaroli; Giulia Andreani; Chiara Bernardini; Augusta Zannoni; Debora La Mantia; Michele Protti; Monica Forni; Laura Mercolini; Gloria Isani
Source:: Research in veterinary science 2022 v.152 pp. 476-484
ISSN:: 0034-5288
Subject:: Artemisia annua; Oriental traditional medicine; antineoplastic activity; artemisinin; cell cycle; culture media; cytotoxicity; dogs; dose response; drug resistance; ferroptosis; lipid peroxidation; liquid chromatography; medicinal plants; osteosarcoma; phenotype; quantitative analysis; research; tandem mass spectrometry; veterinary medicine
Abstract:: ... Since ancient times, Artemisia annua (A. annua) has been used as a medicinal plant in Traditional Chinese Medicine. In addition, recent studies have investigated the cytotoxic effects of A. annua extracts towards cancer cells. The leading aim of the present research is to evaluate the cytotoxic effects of an hydroalcoholic extract of A. annua on two canine osteosarcoma (OSA) cell lines, OSCA-8 and ...
DOI:: 10.1016/j.rvsc.2022.09.012
: https://doi.org/10.1016/j.rvsc.2022.09.012

7. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza)

Author:: Wei GAO; Yi WANG; Ru WANG; Yi-Hai WANG; Jing-Wen XU; Xiang-Jiu HE
Source:: Chinese journal of natural medicines 2022 v.20 no.7 pp. 541-550
ISSN:: 1875-5364
Subject:: Alocasia macrorrhizos; Oriental traditional medicine; antineoplastic activity; apoptosis; neoplasms; phytochemicals; piperidines; rhizomes; spectroscopy; toxicity testing; wild plants
Abstract:: ... The rhizome of giant taro (Alocasia macrorrhiza (L.) Schott), which is a highly adaptable wild plant, is a traditional Chinese herbal medicine. In the current study, the antiproliferative constituents of giant taro were investigated and six new (1−6) and four known piperidine alkaloids (7−10) were isolated from its rhizomes. Their chemical structures and absolute configurations were elucidated usi ...
DOI:: 10.1016/S1875-5364(22)60165-1
: https://doi.org/10.1016/S1875-5364(22)60165-1

8. Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

Author:: Naveenkumar Chandrashekar; Anandakumar Pandi
Source:: Journal of food biochemistry 2022 v.46 no.9 pp. e14230
ISSN:: 0145-8884
Subject:: Oriental traditional medicine; Scutellaria baicalensis; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; autophagy; cell proliferation; flavonoids; herbal tea; human health; ingredients; lung neoplasms; lungs; mechanism of action; metastasis; mortality
Abstract:: ... Plant‐derived flavonoids are reported to function as potential anti‐cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of Scutellaria baicalensis that is popularly used in Chinese medicine as an ingredient in herbal tea preparations to promote wellness. BE has been studied for its several biological effects including antioxidant, anti‐infla ...
DOI:: 10.1111/jfbc.14230
: https://doi.org/10.1111/jfbc.14230

9. Brucea javanica oil emulsion significantly improved the effect of anti–programmed cell death protein-1 immunotherapy

Author:: Jun Meng; Zhixin Yu; Hongying Chen; Xin Yu; Mengshi Jiang; Xin-An Zeng; Jian You
Source:: Phytomedicine 2022 v.107 pp. 154446
ISSN:: 0944-7113
Subject:: Brucea javanica; Oriental traditional medicine; T-lymphocytes; active ingredients; antibodies; antineoplastic activity; cell death; cytokines; cytotoxicity; emulsions; energy transfer; fruits; immunosuppression; immunotherapy; lymph; macrophages; melanoma; mice; models; oils
Abstract:: ... Brucea javanica oil (BJO) is the active substance extracted from the dry and mature fruit of Brucea javanica. Its pharmaceutical preparation, BJO emulsion (BJOE), is one of the most widely studied traditional Chinese medicine preparations for the treatment of malignancy. However, the unrevealed anti-tumor mechanism immensely limits further development of BJOE. In this study, we delved into the ant ...
DOI:: 10.1016/j.phymed.2022.154446
: https://doi.org/10.1016/j.phymed.2022.154446

10. Cancer Cell Inhibiting Sea Cucumber (Holothuria leucospilota) Protein as a Novel Anti-Cancer Drug

Author:: Ruizhen Ru; Yanzheng Guo; Juanxuan Mao; Zonghe Yu; Wen Huang; Xudong Cao; Huijian Hu; Minjie Meng; Lihong Yuan
Source:: Nutrients 2022 v.14 no.4 pp. -
ISSN:: 2072-6643
Subject:: Holothuria leucospilota; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; cell cycle; cell movement; cell viability; death; drug therapy; neoplasm cells; polysaccharides; saponins; toxicity
Abstract:: ... Cancer remains the primary cause of death worldwide. To develop less toxic anti-cancer drugs to relieve the suffering and improve the survival of cancer patients is the major focus in the anti-cancer field. To this end, marine creatures are being extensively studied for their anti-cancer effects, since extracts from at least 10% of the marine organisms have been shown to possess anti-tumor activit ...
DOI:: 10.3390/nu14040786
: https://doi.org/10.3390/nu14040786

11. Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells

Author:: Lingling Zhang; Bing Liang; Huan Xu; Yanju Gong; Wangming Hu; Zhong Jin; Xiao Wu; Xiongbin Chen; Min Li; Liangqin Shi; Yaping Shi; Yong Wang; Lan Yang
Source:: Journal of ethnopharmacology 2022 v.291 pp. 115095
ISSN:: 0378-8741
Subject:: B-lymphocytes; Bufo; Oriental traditional medicine; Western blotting; analgesia; antineoplastic activity; apoptosis; cadherins; cancer therapy; cell proliferation; cell viability; cytotoxicity; drugs; flow cytometry; fluorescent antibody technique; heart failure; histones; immunohistochemistry; lung neoplasms; methyltransferases; mice; pain; secretion; tumor suppressor genes; xenotransplantation; China
Abstract:: ... Bufonis (VB), an animal drug called Chansu in China, is the product of the secretion of Bufo gargarizans Cantor or B. melanostictus Schneider. As a traditional Chinese medicine (TCM) for a long time, it has been widely used in the treatment of heart failure, ulcer, pain, and various cancers. Cinobufaginn (CNB), the cardiotonic steroid or bufalene lactone extracted from VB, has the effects of detox ...
DOI:: 10.1016/j.jep.2022.115095
: https://doi.org/10.1016/j.jep.2022.115095

12. Combination of Compound Kushen Injection and cisplatin shows synergistic antitumor activity in p53-R273H/P309S mutant colorectal cancer cells through inducing apoptosis

Author:: Xingkang Wu; Yufang Lu; Xuemei Qin
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114690
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; adjuvants; antineoplastic activity; apoptosis; cisplatin; colorectal neoplasms; drug therapy; fluorouracil; genes; genetic variation; mutants; necroptosis; prognosis; transcription (genetics); transcriptomics
Abstract:: ... Colorectal cancer (CRC) is one type of worldwide popular and refractory tumors. Compound Kushen Injection (CKI) is a frequently applied traditional Chinese medicine formula as an adjuvant drug for the chemotherapy of CRC. P53 is the most commonly mutated gene in CRC, accounting for the development, malignant and prognosis progression of CRC. However, effect of CKI on the therapeutic efficacy of p5 ...
DOI:: 10.1016/j.jep.2021.114690
: https://doi.org/10.1016/j.jep.2021.114690

13. Comprehensive analysis of antibacterial and anti-hepatoma activity of metabolites from jujube fruit

Author:: Qianqian Shi; Xi Li; Dajun Zhu; Junjun Jiang; Xingang Li
Source:: Food bioscience 2022 v.47 pp. 101511
ISSN:: 2212-4292
Subject:: Oriental traditional medicine; Ziziphus; antineoplastic activity; cosmetics; drugs; fruits; hepatoma; immunity; metabolites; metabolomics; multivariate analysis; procyanidins; sclerosis; China
Abstract:: ... Jujube is one of the most produced dried fruits in China, and it is also a traditional Chinese medicine that enhances immunity and has anti-cancer activity. Jujube fruit is rich in phenolic compounds, but few reports are available on its biological activities. To evaluate the biological activities of the phenolic compounds in dried jujube fruit, the composition and content of metabolites in dried ...
DOI:: 10.1016/j.fbio.2021.101511
: https://doi.org/10.1016/j.fbio.2021.101511

14. Deciphering key regulators of Inonotus hispidus petroleum ether extract involved in anti-tumor through whole transcriptome and proteome analysis in H22 tumor-bearing mice model

Author:: Zhijun Li; Haiying Bao
Source:: Journal of ethnopharmacology 2022 v.296 pp. 115468
ISSN:: 0378-8741
Subject:: Inonotus hispidus; Oriental traditional medicine; antineoplastic activity; gene expression regulation; genes; histopathology; liquid chromatography; mass spectrometry; mushrooms; neoplasms; petroleum; pharmaceutical industry; protein synthesis; proteome; proteomics; sequence analysis; transcriptome; transcriptomics; China
Abstract:: ... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for a long history in China. Our previous research found that I. hispidus petroleum ether extract (IPE) has significant anti-tumor activity. However, the potential anti-tumor regulatory pathways and targets of I. hispidus remain unclear. The present study was envisaged to explore the key regu ...
DOI:: 10.1016/j.jep.2022.115468
: https://doi.org/10.1016/j.jep.2022.115468

15. Effects of ginger extract and its major component 6‐gingerol on anti‐tumor property through mitochondrial biogenesis in CD8+ T cells

Author:: Xiaohong Deng; Dandan Chen; Xianjun Sun; Jingcheng Dong; Jianhua Huang
Source:: Journal of food science 2022 v.87 no.7 pp. 3307-3317
ISSN:: 0022-1147
Subject:: Oriental traditional medicine; antineoplastic activity; biogenesis; coculture; cytotoxicity; food science; ginger; herbal medicines; histopathology; immunity; kidneys; liver; lung neoplasms; lymph; mice; mitochondria; xenotransplantation
Abstract:: ... Ginger extract (GE) and its major component 6‐gingerol (6G) have been reported to exert anti‐tumor effects in various cancers. The underlying mechanism, however, has not been well demonstrated. Here, we have focused on the relationship between promotion of mitochondrial biogenesis in tumor infiltrating CD8⁺ T cells induced by GE and 6G and their cytotoxic effect. The results showed that GE induced ...
DOI:: 10.1111/1750-3841.16228
: https://doi.org/10.1111/1750-3841.16228

16. Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity

Author:: Tianmu He; Qiyi Wang; Jingwen Ao; Kuan Chen; Xiaofei Li; Jianyong Zhang; Cancan Duan
Source:: Food and chemical toxicology 2022 v.163 pp. 112986
ISSN:: 0278-6915
Subject:: Mylabris; Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; bioactive compounds; cantharidin; caspase-3; cytotoxicity; endoplasmic reticulum; endoplasmic reticulum stress; nephrotoxicity; renal function; toxicology
Abstract:: ... Mylabris, as a natural product of traditional Chinese medicine (TCM), exhibiting typical antitumor activity, and cantharidin (CTD) is the major bioactive component. However, drug-induced nephrotoxicity (DIN) extremely limited its clinical application. In this study, we proved that activation of the endoplasmic reticulum (ER) stress-dependent PERK/CHOP pathway exerts a toxic role in rats and HK-2 c ...
DOI:: 10.1016/j.fct.2022.112986
: https://doi.org/10.1016/j.fct.2022.112986

17. Evaluation of the antimicrobial function of Ginkgo biloba exocarp extract against clinical bacteria and its effect on Staphylococcus haemolyticus by disrupting biofilms

Author:: Cong Wang; Peng-Wei Wei; Chao-Rong Song; Xu Wang; Gao-Feng Zhu; Yong-Xin Yang; Guo-Bo Xu; Zu-Quan Hu; Lei Tang; Hong-Mei Liu; Bing Wang
Source:: Journal of ethnopharmacology 2022 v.298 pp. 115602
ISSN:: 0378-8741
Subject:: Acinetobacter baumannii; Ginkgo biloba; Oriental traditional medicine; Staphylococcus epidermidis; Staphylococcus haemolyticus; antibacterial properties; antibiotic resistance; antineoplastic activity; asthma; bacterial growth; biochemical pathways; biofilm; biosynthesis; blood; brain; calcium oxide; cough; disinfectants; dose response; electron microscopy; environmental DNA; exocarp; folic acid; gene expression; gentian violet; homeopathic drugs; liquids; methicillin-resistant Staphylococcus aureus; multiple drug resistance; quantitative polymerase chain reaction; transcriptome
Abstract:: ... The fruit of Ginkgo biloba L. (Ginkgo nuts) has been used for a long time as a critical Chinese medicine material to treat cough and asthma, as well as a disinfectant. Similar records were written in the Compendium of Materia Medica (Ben Cao Gang Mu, pinyin in Chinese) and Sheng Nong's herbal classic (Shen Nong Ben Cao Jing, pinyin in Chinese). Recent research has shown that Ginkgo biloba exocarp ...
DOI:: 10.1016/j.jep.2022.115602
: https://doi.org/10.1016/j.jep.2022.115602

18. Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation

Author:: Jing Ying Wang; Ming Wen Jiang; Ming Yue Li; Zhi Hong Zhang; Yue Xing; MyongHak Ri; Cheng Hua Jin; Guang Hua Xu; Lian Xun Piao; Hong Lan Jin; Juan Ma; Yong Jin; Hong Xiang Zuo; Xuejun Jin
Source:: Journal of nutritional biochemistry 2022 v.100 pp. 108899
ISSN:: 0955-2863
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; biogenesis; blood glucose; carcinogenesis; cell movement; cell proliferation; coculture; cytotoxicity; diet therapy; formononetin; immunity; inflammation; liver; lysosomes; mice; models; neoplasm cells; precipitin tests; protein degradation; protein synthesis; research and development; uterine cervical neoplasms; xenotransplantation
Abstract:: ... A. membranaceus is a traditional Chinese medicine that regulates blood sugar levels, suppresses inflammation, protects the liver, and enhances immunity. In addition, A. membranaceus is also widely used in diet therapy and is a well-known health tonic. Formononetin is a natural product isolated from A. membranaceus that has multiple biological functions, including anti-cancer activity. However, the ...
DOI:: 10.1016/j.jnutbio.2021.108899
: https://doi.org/10.1016/j.jnutbio.2021.108899

19. Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms

Author:: Xia Li; Han Yu; Yanju Gong; Peijie Wu; Quansheng Feng; Chao Liu
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114801
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; antineoplastic activity; arachidonic acid; bile secretion; blood chemistry; diethylnitrosamine; hepatoma; high performance liquid chromatography; histopathology; liver; peroxisome proliferator-activated receptors; phenotype; prediction; rats; therapeutics
Abstract:: ... Fuzheng Xiaozheng prescription (FZXZP) is a traditional Chinese medicine (TCM) that was derived from Sanjiasan, a famous decoction documented in the book of Wenyilun in Ming dynasty. Based on our years’ clinic application, FZXZP demonstrated satisfactory therapeutic effects in cirrhosis and hepatocellular carcinoma (HCC) treatments. However, the underlying mechanisms are still largely unknown.In t ...
DOI:: 10.1016/j.jep.2021.114801
: https://doi.org/10.1016/j.jep.2021.114801

20. Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma

Author:: Fuhao Huang; Jinlong Pang; Liansong Xu; Wenwen Niu; Yaoshuai Zhang; Shanshan Li; Xian Li
Source:: Phytomedicine 2022 v.104 pp. 154319
ISSN:: 0944-7113
Subject:: Oldenlandia diffusa; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; drug therapy; electron microscopy; ferroptosis; lipids; lung neoplasms; lungs; malondialdehyde; mice; models; mortality; neoplasm cells; plasmids; reactive oxygen species; toxicity; viability; xenotransplantation
Abstract:: ... Lung cancer has the highest mortality rate among all cancer types. In combination with multiple chemotherapeutic options, traditional Chinese medicine has proven indispensable for the comprehensive treatment of lung cancer. To investigate the effects of Hedyotis diffusa on lung adenocarcinoma cell lines and a BALB/c nude mouse xenograft model, and determine whether HDI could induce ferroptosis in ...
DOI:: 10.1016/j.phymed.2022.154319
: https://doi.org/10.1016/j.phymed.2022.154319

21. Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation

Author:: Bao-Yue ZHANG; Yi-Fu ZHENG; Jun ZHAO; De KANG; Zhe WANG; Lv-Jie XU; Ai-Lin LIU; Guan-Hua DU
Source:: Chinese journal of natural medicines 2022 v.20 no.5 pp. 332-351
ISSN:: 1875-5364
Subject:: Bayesian theory; Oriental traditional medicine; algorithms; antineoplastic activity; chemical structure; computer simulation; databases; flavonoids; genes; prediction; terpenoids; therapeutics
Abstract:: ... Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes, and multi-target drugs provide a promising therapy idea for the treatment of cancer. Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs. In this paper, 50 tumor-related targets were collect ...
DOI:: 10.1016/S1875-5364(22)60180-8
: https://doi.org/10.1016/S1875-5364(22)60180-8

22. Identifying the anti-metastasis effect of Anhydroicaritin on breast cancer: Coupling network pharmacology with experimental validation

Author:: Youyang Shi; Yuanyuan Wu; Feifei Li; Yang Zhang; Ciyi Hua; Jianfeng Yang; Jinzhou Zheng; Lili Chen; Zheng Wei; Haiyan Yue; Chenping Sun; Xiqiu Zhou; Sheng Liu
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115326
ISSN:: 0378-8741
Subject:: Cullen corylifolium; Epimedium brevicornu; Oriental traditional medicine; Western blotting; active ingredients; antineoplastic activity; breast neoplasms; cell proliferation; databases; drugs; high performance liquid chromatography; lungs; metastasis; neoplasm cells; protein-protein interactions; reverse transcriptase polymerase chain reaction
Abstract:: ... Epimedium brevicornu Maxim. and Cullen corylifolium (L.) Medik. are part of a traditional Chinese medicine (TCM) drug pair (ECDP) widely used in the clinical treatment of breast cancer (BC). Both drugs have been proven to have anti-tumor effect. However, the active ingredients and molecular mechanism of ECDP remain to be explored. Aim of the study: To explore the efficacy and potential mechanisms ...
DOI:: 10.1016/j.jep.2022.115326
: https://doi.org/10.1016/j.jep.2022.115326

23. Induction of P-glycoprotein expression by dandelion in tumor and heart tissues: Impact on the anti-tumor activity and cardiotoxicity of doxorubicin

Author:: Jiameng Qu; Fan Ke; Xiao Yang; Yue Wang; Huarong Xu; Qing Li; Kaishun Bi
Source:: Phytomedicine 2022 v.104 pp. 154275
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; P-glycoproteins; Taraxacum; antineoplastic activity; biomarkers; breast neoplasms; cardiomyocytes; cardioprotective effect; cardiotoxicity; cytotoxicity; doxorubicin; drug therapy; flow cytometry; histology; metabolomics; mice
Abstract:: ... Previously, we have investigated the anti-tumor activity and mechanism through which dandelion acts against triple-negative breast cancer (TNBC). However, traditional Chinese medicine is mostly accepted as an adjunct therapy during chemotherapy in clinical practice. So far, little is known about the effects of dandelion in conjunction with chemotherapeutic drugs. To investigate the effects of dand ...
DOI:: 10.1016/j.phymed.2022.154275
: https://doi.org/10.1016/j.phymed.2022.154275

24. Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer

Author:: Fan Gao; Yuju Niu; Luyao Sun; Wenwen Li; Haojie Xia; Yaru Zhang; Shengnan Geng; Zhenzhen Guo; Haihong Lin; Gangjun Du
Source:: Journal of ethnopharmacology 2022 v.298 pp. 115573
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; allografting; antineoplastic activity; asthma; carcinogenicity; chest; cough; databases; dose response; immunomodulation; lung neoplasms; lungs; mice; models; monitoring; myeloperoxidase; neoplasm progression; neutrophils; pain; phagocytosis; protein-protein interactions; sinomenine; transcriptomics; China
Abstract:: ... Mufangji decoction (MFJD), a famous traditional Chinese medicine formula in Synopsis of Golden Chamber (Jingui yaolue), has been utilized to treat cough and asthma and release chest pain over 2000 years in China. Chinese old herbalist doctor use MFJD to treat lung cancer and cancerous pleural fluid, but the preventive effect of MFJD on lung cancer and the underlying mechanism are indefinite. The g ...
DOI:: 10.1016/j.jep.2022.115573
: https://doi.org/10.1016/j.jep.2022.115573

25. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

Author:: Xuelin Mo; Dongkai Guo; Yiguo Jiang; Ping Chen; Lifeng Huang
Source:: International journal of biological macromolecules 2022 v.199 pp. 212-222
ISSN:: 0141-8130
Subject:: Oriental traditional medicine; antineoplastic activity; antioxidant activity; dose response; flavonoids; glycemic effect; glycosides; immunity; intestinal microorganisms; medicinal plants; molecular weight; phenylpropanoids; polysaccharides; structure-activity relationships; therapeutics; China
Abstract:: ... Radix Hedysari, a well-known traditional Chinese herbal medicine, has a long history as a medicinal plant in China based on its wide spectrum of biological and pharmacological activities. Until now, many chemical constituents have been isolated and identified from Radix Hedysari, such as polysaccharides, flavonoids, phenylpropanoids, trace elements and so on. Of these, Radix Hedysari polysaccharid ...
DOI:: 10.1016/j.ijbiomac.2021.12.095
: https://doi.org/10.1016/j.ijbiomac.2021.12.095

26. Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy

Author:: Zhu Zhang; Wen-qing Chen; Shi-qing Zhang; Jing-xuan Bai; Bin Liu; Ken Kin-Lam Yung; Joshua Ka-Shun Ko
Source:: Phytomedicine 2022 v.106 pp. 154406
ISSN:: 0944-7113
Subject:: Glycyrrhiza glabra; Oriental traditional medicine; antineoplastic activity; apoptosis; autophagosomes; autophagy; cancer therapy; cell growth; cytotoxicity; drug therapy; flavonoids; flow cytometry; fluorescence microscopy; fluorouracil; growth retardation; immunoblotting; metastasis; mitogen-activated protein kinase; models; neoplasm cells; neoplasm progression; pancreatic neoplasms; phosphorylation; prognosis; rapamycin; survival rate; toxicity testing; transmission electron microscopy
Abstract:: ... Pancreatic cancer has been characterized by poor prognosis, early metastasis and dissatisfactory treatment outcome. The high basal level of autophagy in tumor cells leads to chemoresistance and tumor progression. Thus, it is imminent to explore novel effective chemotherapeutic adjuvants to increase patients’ survival rate. Isoliquiritigenin (ISL) is a bioactive flavonoid obtained from the Traditio ...
DOI:: 10.1016/j.phymed.2022.154406
: https://doi.org/10.1016/j.phymed.2022.154406

27. Plant polypeptides: A review on extraction, isolation, bioactivities and prospects

Author:: Wenqi Wang; Zhicheng Liu; Yongjian Liu; Zhijun Su; Yonggang Liu
Source:: International journal of biological macromolecules 2022 v.207 pp. 169-178
ISSN:: 0141-8130
Subject:: Oriental traditional medicine; antibacterial properties; antineoplastic activity; blood pressure; glycemic effect; lipemic effect; polypeptides; purification methods; China
Abstract:: ... The application of traditional Chinese medicine has a long history in China with unique advantages and functions. With the rapid development of separation and purification technologies, more and more polypeptide compounds with specific biological activity and medicinal value were isolated from natural plants. The plant polypeptides have a lot of biological activities, such as antitumor effect, ant ...
DOI:: 10.1016/j.ijbiomac.2022.03.009
: https://doi.org/10.1016/j.ijbiomac.2022.03.009

28. Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering‐based high‐performance liquid chromatography–quadrupole time‐of‐flight tandem mass spectrometry

Author:: Li Cheng; Fang Wang; Yuanxin Cao; Chaoying Tong; Qisheng Wei; Shuyun Shi; Ying Guo
Source:: Phytochemical analysis 2022 v.33 no.6 pp. 895-905
ISSN:: 0958-0344
Subject:: Citrus; Oriental traditional medicine; antineoplastic activity; flavonoids; fluorouracil; human cell lines; tandem mass spectrometry
Abstract:: ... INTRODUCTION: Citri Reticulatae Pericarpium Viride (CRPV, Qing Pi in Chinese) has been widely used in traditional Chinese medicine. Polymethoxylated flavonoids (PMFs), which are a special group of flavonoids with strong antitumor activity, are broadly distributed in citrus peels. However, systematic investigation of antitumor PMFs in CRPV has received little attention to date. OBJECTIVES: An MCF‐7 ...
DOI:: 10.1002/pca.3147
: https://doi.org/10.1002/pca.3147

29. Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review

Author:: Alaa F. Bakr; Ping Shao; Mohamed A. Farag
Source:: Phytomedicine 2022 v.99 pp. 153999
ISSN:: 0944-7113
Subject:: COVID-19 infection; Glycyrrhiza glabra; Oriental traditional medicine; antineoplastic activity; antioxidants; antiviral properties; cosmetics; glycyrrhizin; licorice; metabolism; molecular biology; nanomedicine; particle size; saponins; systematic review; triterpenoids; viruses
Abstract:: ... Glycyrrhizin (GL) is a major active constituent of licorice root (Glycyrrhiza glabra) that is considered one of the oldest and most frequently employed botanicals in Chinese medicine and worldwide, with most effects attributed to its rich GL content. Structurally, GL a triterpene saponin that is widely used as a flavoring agent in foodstuffs and cosmetics, and also proposed for various clinical ap ...
DOI:: 10.1016/j.phymed.2022.153999
: https://doi.org/10.1016/j.phymed.2022.153999

30. Research progress of matrine's anticancer activity and its molecular mechanism

Author:: Fengyuan Chen; Yunxia Pan; Jing Xu; Bin Liu; Hang Song
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114914
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Sophora flavescens; alkaloids; angiogenesis; anti-allergic agents; antineoplastic activity; apoptosis; autophagy; cancer therapy; cardioprotective effect; cell cycle checkpoints; cell differentiation; cell growth; cold; death; heat; metastasis; multiple drug resistance; neoplasm cells; urination
Abstract:: ... and ethnopharmacological relevance: Matrine (MT), a type of alkaloid extracted from the Sophora family of traditional Chinese medicine, has been documented to exert a variety of pharmacological effects, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrosis, and cardiovascular protection. Sophora flavescens Aiton is a traditional Chinese medicine that is bitter and cold. Additionall ...
DOI:: 10.1016/j.jep.2021.114914
: https://doi.org/10.1016/j.jep.2021.114914

31. Sanguisorba officinalis L. suppresses 5-fluorouracil-sensitive and-resistant colorectal cancer growth and metastasis via inhibition of the Wnt/β-catenin pathway

Author:: Weijia Zhang; Chang Peng; Jiahui Yan; Pengting Chen; Cheng Jiang; Shuyi Sang; Yuemei Yuan; Yanjun Hong; Meicun Yao
Source:: Phytomedicine 2022 v.94 pp. 153844
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; Sanguisorba officinalis; antineoplastic activity; apoptosis; cadherins; cell growth; cell movement; cell proliferation; cell viability; colorectal neoplasms; cytoplasm; fluorouracil; metastasis; morbidity; mortality; protein synthesis; snails; vimentin; xenotransplantation
Abstract:: ... Colorectal cancer (CRC) is a widespread cancer with high morbidity and mortality. Chemoresistance and metastasis are the current challenges for CRC treatment. Sanguisorba officinalis Linn. (called DiYu in Chinese, DY) is a traditional Chinese medicine (TCM) whose root is long used as medicinal part. In our previous study, the aqueous extract of DY could inhibit the Wnt/β-catenin pathway and showed ...
DOI:: 10.1016/j.phymed.2021.153844
: https://doi.org/10.1016/j.phymed.2021.153844

32. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-κB signaling in hepatocellular carcinoma cells

Author:: Bingling Dai; Mengying Fan; Xiaoyue Huang; Zhengyan Gong; Hanbing Cao; Yu Hu; Qi Su; Tianfeng Yang; Yanbin Chen; Xiujuan Peng; Feng Liu; Yanmin Zhang
Source:: Phytomedicine 2022 v.103 pp. 154249
ISSN:: 0944-7113
Subject:: Oldenlandia; Oriental traditional medicine; Prunella; Western blotting; antineoplastic activity; chronic hepatitis; fluorescent antibody technique; hepatoma; inflammasomes; mortality; reactive oxygen species; therapeutics
Abstract:: ... Hepatocellular carcinoma (HCC) is a major subtype of liver cancer, with a high mortality rate, and close relation to chronic hepatitis. The components of the NLRP3 inflammasome are poorly expressed or even lost in HCC. Downregulation of the NLRP3 inflammasome expression significantly affects the clinical stages and pathological grade of HCC. According to previous research, Shuanghua decoction (SHD ...
DOI:: 10.1016/j.phymed.2022.154249
: https://doi.org/10.1016/j.phymed.2022.154249

33. Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum

Author:: Tian Luo; Xuemei Deng; Zhao Li; Dan Liu; Huaixiu Wen; Zhen Wang
Source:: Phytochemistry letters 2022 v.51 pp. 119-126
ISSN:: 1874-3900
Subject:: Oriental traditional medicine; alkaloids; antineoplastic activity; apoptosis; carcinoma; cell proliferation; hepatoma; metastasis; mitochondria; plant biochemistry; xenotransplantation
Abstract:: ... Hypecoum leptocarpum is a traditional Tibetan Medicine, which has been shown to have anti-cancer properties. Therefore, developing anti-cancer activity compounds from Hypecoum leptocarpum is very valuable. Notably, corydamine, an isoquinoline alkaloid, is isolated from Hypecoum leptocarpum. Given the anti-cancer value of Hypecoum leptocarpum, lucubrating the anti-cancer activity of corydamine is o ...
DOI:: 10.1016/j.phytol.2022.08.006
: https://doi.org/10.1016/j.phytol.2022.08.006

34. The antitumour activity of C21 steroidal glycosides and their derivatives of Baishouwu: A review

Author:: Xia Zhang; Ming Gao; Zhili Rao; Ziqin Lei; Jiuseng Zeng; Zhangjun Huang; Caihong Shen; Nan Zeng
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115300
ISSN:: 0378-8741
Subject:: Cynanchum wilfordii; Oriental traditional medicine; antineoplastic activity; apoptosis; blood; carcinogenesis; cell cycle; cholesterol; glycosides; homeopathic drugs; immunity; kidneys; liver; metastasis; neoplasm cells; neoplasms; wind; China
Abstract:: ... Baishouwu has been used in China for thousands of years since it was first discovered in the late Tang Dynasty and flourished in the Song and Ming Dynasties. The Chinese herbal medicines named Baishouwu include Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii Hemsl. It is described in the Sign of Materia Medica as “sweet, bitter, reinforce liver and kidney, an ...
DOI:: 10.1016/j.jep.2022.115300
: https://doi.org/10.1016/j.jep.2022.115300

35. A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma

Author:: Jingjing Zhang; Yangliu Tong; Xun Lu; Fangming Dong; Xiaoxuan Ma; Shiyu Yin; Ying He; Yonghong Liu; Qingchao Liu; Daidi Fan
Source:: Life sciences 2022 v.304 pp. 120698
ISSN:: 0024-3205
Subject:: Oriental traditional medicine; acetylation; adverse effects; antineoplastic activity; apoptosis; cytotoxicity; death; flow cytometry; fluorescent antibody technique; ginsenosides; growth and development; hepatoma; immunoblotting; models; neoplasm cells; phosphorylation; transcription factors; transcriptomics; xenotransplantation
Abstract:: ... Epidemiological studies have shown that hepatocellular carcinoma (HCC) is a main cause of tumor death worldwide. Accumulating data indicate that ginsenoside CK is an effective compound for preventing HCC growth and development. However, improvement of pharmaceutical effect of the ginsenoside CK is still needed. In our study, we performed acetylation of ginsenoside CK (CK-3) and investigated the an ...
DOI:: 10.1016/j.lfs.2022.120698
: https://doi.org/10.1016/j.lfs.2022.120698

36. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Author:: Xin Sun; Yeting Hong; Yuhan Shu; Caixia Wu; Guiqin Ye; Hanxiao Chen; Hongying Zhou; Ruilan Gao; Jianbin Zhang
Source:: Journal of Ginseng Research 2022 v.46 no.2 pp. 266-274
ISSN:: 1226-8453
Subject:: Oriental traditional medicine; Panax ginseng; antineoplastic activity; colorectal neoplasms; energy metabolism; enzymes; ginsenosides; humans; mitochondria; mitophagy; mortality; oxidative stress; prognosis; research; ubiquitin; ubiquitination
Abstract:: ... Colon cancer, the third most frequent occurred cancer, has high mortality and extremely poor prognosis. Ginsenoside, the active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effect in various cancers, including colon cancer. However, the detailed molecular mechanism of Ginsenoside in the tumor suppression have not been fully elucidated. Here, we chose the repres ...
DOI:: 10.1016/j.jgr.2021.06.009
: https://doi.org/10.1016/j.jgr.2021.06.009

37. Aloe vera gel extract: Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells

Author:: Xueli Tong; Min Li; Di Li; Chunqin Lao; Jingmian Chen; Weijie Xu; Junxi Du; Meijiao Zhang; Xiangcai Yang; Jiejing Li
Source:: Journal of ethnopharmacology 2021 v.280 pp. 114434
ISSN:: 0378-8741
Subject:: Aloe vera; Oriental traditional medicine; acute toxicity; adenosine triphosphate; antineoplastic activity; apoptosis; breasts; chronic toxicity; constipation; cytotoxicity; gels; high performance liquid chromatography; immune system; lung neoplasms; malic acid; metabolism; mitochondria; necrosis; neoplasm cells; oral administration; reactive oxygen species; tandem mass spectrometry; China
Abstract:: ... Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015). It has been traditionally used for the treatment of constipation, and its potential therapeutic activities have been widely evaluated, including anti-tumor, anti-inflammatory and immune regulatory effects. The wide application of Aloe vera in food ...
DOI:: 10.1016/j.jep.2021.114434
: https://doi.org/10.1016/j.jep.2021.114434

38. Anti-esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways

Author:: Chaoqun Wu; Huiqi Huang; Ho-Young Choi; Yuanren Ma; Tongxi Zhou; Yu Peng; Kejian Pang; Guangwen Shu; Xinzhou Yang
Source:: Journal of ethnopharmacology 2021 v.269 pp. 113700
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; cell growth; chromatography; cytotoxicity; dose response; endoplasmic reticulum stress; esophageal neoplasms; flow cytometry; mitochondria; neoplasm progression
Abstract:: ... Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from the traditional ethnopharmacological plant Phmllanthi Fructus, which is widely used in not only traditional Chinese medicine but also tropical and subtropical medicine to ameliorate various diseases. This study was designed to isolate the potential anti-esophageal cancer (EC) component corilagin from Phmllan ...
DOI:: 10.1016/j.jep.2020.113700
: https://doi.org/10.1016/j.jep.2020.113700

39. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway

Author:: Liying Wang; Jinpo Gu; Mingyue Zong; Qingran Zhang; Huixiang Li; Danna Li; Xiaofeng Mou; Pan Liu; Yanan Liu; Feng Qiu; Feng Zhao
Source:: Journal of ethnopharmacology 2021 v.267 pp. 113490
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Physalis; acetic acid; active ingredients; anti-inflammatory activity; antineoplastic activity; calyx; dose response; edema; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; necrosis; neoplasms; nitric oxide; permeability; phosphorylation; prostaglandin synthase; prostaglandins; respiratory tract diseases; signal transduction; sorbents; transcription factor NF-kappa B; China
Abstract:: ... Physalis Calyx seu Fructus is typically used to treat inflammatory diseases such as upper respiratory tract infection and acute tonsillitis in clinical practice of China. Physalin A, a main active ingredient of this traditional Chinese medicine (TCM), has been reported for its significant anti-tumor activity. However, most reports focused on the studies of its anti-tumor activity, the anti-inflamm ...
DOI:: 10.1016/j.jep.2020.113490
: https://doi.org/10.1016/j.jep.2020.113490

40. Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression

Author:: Yan Liu; Ming Chang; Zhaoliang Hu; Xin Xu; Wei Wu; Manru Ning; Taijun Hang; Min Song
Source:: Journal of ethnopharmacology 2021 v.273 pp. 113965
ISSN:: 0378-8741
Subject:: DNA; Oriental traditional medicine; antigens; antineoplastic activity; bone marrow; deoxycytidine; interphase; lung neoplasms; quality of life; synergism; thrombopoietin
Abstract:: ... Danggui Buxue Decoction (DBD) as a traditional Chinese medicine (TCM) has been widely used to treat blood deficiency. With the immune regulation and hematopoietic effect, DBD improved the quality of life in non-small-cell lung cancer (NSCLC) patients. We previously reported that DBD sensitized the response of NSCLC to Gemcitabine (Gem); however, the synergism and attenuation mechanism on the combi ...
DOI:: 10.1016/j.jep.2021.113965
: https://doi.org/10.1016/j.jep.2021.113965

41. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity

Author:: Ao Yang; Ming Yue Li; Zhi Hong Zhang; Jing Ying Wang; Yue Xing; MyongHak Ri; Cheng Hua Jin; Guang Hua Xu; Lian Xun Piao; Hong Lan Jin; Hong Xiang Zuo; Juan Ma; Xuejun Jin
Source:: Journal of ethnopharmacology 2021 v.273 pp. 113598
ISSN:: 0378-8741
Subject:: Dendrobium chrysotoxum; Oriental traditional medicine; Western blotting; analgesics; angiogenesis; antineoplastic activity; cell proliferation; coculture; cytotoxicity; flow cytometry; human cell lines; immunotherapy; ligands; lysosomes; precipitin tests; programmed cell death; quality control; uterine cervical neoplasms; xenotransplantation; China
Abstract:: ... Dendrobium chrysotoxum Lindl is a cultivation of Dendrobium which belongs to the family of Orchidaceae. D. chrysotoxum Lindl is a traditional Chinese medicine with a wide range of clinical applications including tonic, astringent, analgesic and anti-inflammatory properties as early as the 28th century B.C. Erianin is a representative index component for the quality control of the D. chrysotoxum Li ...
DOI:: 10.1016/j.jep.2020.113598
: https://doi.org/10.1016/j.jep.2020.113598

42. Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology

Author:: Ya-Nan Li; Jun He; Jia Zhang; Ying-Xue Shi; Lin-Bo Guo; Zhong-Can Peng; Ting Yang; Kang Ding; Wei-Ku Zhang; Jie-Kun Xu
Source:: Journal of ethnopharmacology 2021 v.275 pp. 114095
ISSN:: 0378-8741
Subject:: Euphorbia fischeriana; Oriental traditional medicine; acetophenones; altitude; antineoplastic activity; cough; coumarins; diterpenoids; flavonoids; flora; grasses; grasslands; gravel; hills; indigestion; lymph; meroterpenoids; pain; scabies; systematic review; toxicity; toxicology; triterpenoids; tuberculosis; vision; China
Abstract:: ... Euphorbia fischeriana Steud. (Euphorbiaceae) is a perennial herb distributed in grassland, hill slopes or gravel hillside, with average altitude of 100–600 m. The whole grass of E. fischeriana is toxic with roots used as folk medicine to treat Zhushui, dyspepsia, abdominal distension, abdominal pain, cough, as well as external applications such as cure of scabies and tuberculosis of lymph nodes.Th ...
DOI:: 10.1016/j.jep.2021.114095
: https://doi.org/10.1016/j.jep.2021.114095

43. Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

Author:: Jia Xiong Ming; Zhao Cong Wang; Yi Huang; Hifumi Ohishi; Rong Ji Wu; Yan Shao; Hui Wang; Ming Yang Qin; Ze Liang Wu; Yi Yong Li; Shun Chang Zhou; Hui Chen; Hui Liu; Rong Xu
Source:: Journal of ethnopharmacology 2021 v.265 pp. 113302
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; RNA interference; Saccharina japonica; Western blotting; antineoplastic activity; cadherins; cell lines; cell proliferation; cell viability; drugs; fibronectins; fluorescent antibody technique; gene expression; human diseases; immunohistochemistry; lung neoplasms; lungs; metastasis; models; neoplasm cells; phenotype; phosphatidylinositol 3-kinase; staining; tissue repair; transcription factor NF-kappa B; xenotransplantation
Abstract:: ... Laminaria japonica, a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including lung cancer.To demonstrate the effects of Fucoxanthin (FX), a major active component extracted from Laminaria japonica on metastasis and Gefitinib (Gef) sensitivity in human lung cancer cells both in vitro and in vivo.Invasion and migration of lung cancer cells were det ...
DOI:: 10.1016/j.jep.2020.113302
: https://doi.org/10.1016/j.jep.2020.113302

44. Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis

Author:: Nan-Nan Tian; Yan-Biao Zheng; Zhi-Peng Li; Feng-wei Zhang; Jin-fang Zhang
Source:: Journal of ethnopharmacology 2021 v.280 pp. 114413
ISSN:: 0378-8741
Subject:: Curcuma kwangsiensis; Oriental traditional medicine; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; epigenetics; hepatoma; histones; metastasis; methyltransferases; transcription (genetics); China
Abstract:: ... Curcuma kwangsiensis S. G. Lee & C. F. Liang (Guangxi ezhu, in Chinese) has been used as a traditional Chinese medicine (TCM) for approximately 2000 years. Curcumol is one of the major bioactive components of this herb, which has been demonstrated possesses anti-cancer properties, and was recorded in the Chinese Pharmacopoeia 2020 edition. However, most studies mainly focused on the superficial an ...
DOI:: 10.1016/j.jep.2021.114413
: https://doi.org/10.1016/j.jep.2021.114413

45. Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

Author:: Qian Xie; Yang Liu; Ying Long; Zhou Wang; Sai Jiang; Rida Ahmed; Muhammad Daniyal; Bin Li; Bin Liu; Wei Wang
Source:: Biomaterials science 2021 v.9 no.8 pp. 2991-3004
ISSN:: 2047-4849
Subject:: Oriental traditional medicine; Panax japonicus; antineoplastic activity; apoptosis; biocompatible materials; breast neoplasms; cancer therapy; cell membranes; cell proliferation; chlorins; death; half life; immune evasion; neoplasm cells; solubility
Abstract:: ... Breast cancer is the most common cancer in women and occurs mostly with poor outcomes. Our objective was to endow synthetic lethality to the phytoconstituent chikusetsusaponin IVa methyl ester (CSME, S), a special phytoconstituent from traditional Chinese medicine (TCM), Panax japonicus, with the photodynamic agent chlorin e6 (Ce6, C) and enhance the therapeutic efficacy against breast cancer usin ...
DOI:: 10.1039/d0bm02211j
: https://doi.org/10.1039/d0bm02211j

46. Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

Author:: Sara Hassan Hassan Ahmed; Tímea Gonda; Attila Hunyadi
Source:: RSC advances 2021 v.11 no.43 pp. 26687-26699
ISSN:: 2046-2069
Subject:: Oriental traditional medicine; Zingiber officinale; antiemetics; antineoplastic activity; antioxidants; derivatization; ginger; secondary metabolites
Abstract:: ... Ginger (Zingiber officinale Roscoe) has been used as a spice and as a traditional remedy since ancient times, especially in traditional Chinese medicine. It has been applied as a treatment for many diseases either alone or in combination with other remedies. Many studies were conducted on ginger and its constituents and a wide array of bioactivities were reported, e.g., antioxidant, anti-inflammat ...
DOI:: 10.1039/d1ra04227k
: https://doi.org/10.1039/d1ra04227k

47. Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation

Author:: Dandan Guo; Chengjie Guo; Liu Fang; Tingting Sang; Yujie Wang; Kaikai Wu; Cuiling Guo; Ying Wang; Haitao Pan; Rong Chen; Xingya Wang
Source:: Journal of ethnopharmacology 2021 v.273 pp. 113964
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; breasts; cachexia; caspase-3; caspase-9; colorectal neoplasms; flow cytometry; fluorescent antibody technique; lungs; mice; nonsteroidal anti-inflammatory agents; phosphorylation; toxicity; toxicity testing; viability; weight loss; xenotransplantation
Abstract:: ... Qizhen capsule (QZC) is a traditional Chinese medicine (TCM) preparation that has been widely used in clinical practice and exerts promising therapeutic effects against breast, lung, and gastric cancers. However, studies have not reported whether QZC inhibits colorectal cancer (CRC) development and progression. Meanwhile, the underlying molecular mechanisms of its anticancer activity have not been ...
DOI:: 10.1016/j.jep.2021.113964
: https://doi.org/10.1016/j.jep.2021.113964

48. RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells

Author:: Jing Wang; Jia Wang; Ling Li; Li Feng; Yu-Rong Wang; Zhe Wang; Ning-Hua Tan
Source:: Journal of ethnopharmacology 2021 v.266 pp. 113438
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Rubia; active ingredients; antineoplastic activity; apoptosis; autophagosomes; autophagy; cancer therapy; cathepsins; cell cycle checkpoints; colorectal neoplasms; cytotoxicity; fluorescence; glucosides; humans; membrane potential; mitochondrial membrane; plasmids; protein synthesis; rheumatoid arthritis; transfection; tuberculosis; China
Abstract:: ... The roots of Rubia yunnanensis Diels (Chinese name ‘Xiao-Hong-Shen’), a traditional Chinese medicine native to Yunnan province (China), have a long history of use for treating several diseases, such as tuberculosis, rheumatism and cancers. A bicyclic hexapeptidic glucoside named RA-XII was isolated from R. yunnanensis, which has been reported to exert anti-inflammatory and antitumor activities.Thi ...
DOI:: 10.1016/j.jep.2020.113438
: https://doi.org/10.1016/j.jep.2020.113438

49. Remodeling the homeostasis of pro- and anti-angiogenic factors by Shenmai injection to normalize tumor vasculature for enhanced cancer chemotherapy

Author:: Lingge Cheng; Wenyue Liu; Chongjin Zhong; Ping Ni; Suiying Ni; Qizhi Wang; Qixiang Zhang; Jingwei Zhang; Jiali Liu; Meijuan Xu; Xuequan Yao; Xiaobo Cen; Guangji Wang; Chao Jiang; Fang Zhou
Source:: Journal of ethnopharmacology 2021 v.270 pp. 113770
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; acetylation; antineoplastic activity; blood; colorectal neoplasms; drug therapy; fluorescent antibody technique; fluorouracil; gene expression; histones; homeostasis; microscopy; microvessels; plasminogen; protein synthesis; proteolysis; transcription (genetics); xenotransplantation
Abstract:: ... Normalization of the tumor vasculature can enhance tumor perfusion and the microenvironment, leading to chemotherapy potentiation. Shenmai injection (SMI) is a widely used traditional Chinese herbal medicine for the combination treatment of cancer in China. This study aimed to investigate whether SMI can regulate tumor vasculature to improve chemotherapy efficacy and identify the underlying mechan ...
DOI:: 10.1016/j.jep.2020.113770
: https://doi.org/10.1016/j.jep.2020.113770

50. Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells

Author:: Ling Li; Jia Wang; Li Feng; Junting Fan; Jing Wang; Ninghua Tan; Zhe Wang
Source:: Journal of ethnopharmacology 2021 v.277 pp. 114184
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Rubia; active ingredients; antineoplastic activity; apoptosis; autophagy; breast neoplasms; cancer therapy; cell cycle; cell movement; cell viability; dose response; drug therapy; flow cytometry; gelatin; lungs; metastasis; models; plasmids; transfection
Abstract:: ... Rubia yunnanensis Diels is a traditional Chinese medicine that has diverse pharmacological activities, including antituberculosis, antirheumatism and anticancers. Rubioncolin C (RC), a natural naphthohydroquinone dimer isolated from the roots and rhizomes of R. yunnanensis Diels, has shown potent antitumor activity. However, the antitumor activity and its potential mechanism of RC in triple-negati ...
DOI:: 10.1016/j.jep.2021.114184
: https://doi.org/10.1016/j.jep.2021.114184

51. Scutellariabarbata D. Don extraction selectively targets stemness-prone NSCLC cells by attenuating SOX2/SMO/GLI1 network loop

Author:: Wei-Wei Chen; Kai-Kai Gong; Li-Juan Yang; Juan-Juan Dai; Qian Zhang; Feng Wang; Xue-Lin Li; Si-Chuan Xi; Jing Du
Source:: Journal of ethnopharmacology 2021 v.265 pp. 113295
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; adverse effects; antineoplastic activity; cisplatin; drug therapy; epithelial cells; lung neoplasms; mice; models; neoplasm cells; patients; phenotype; transcription factors; xenotransplantation
Abstract:: ... Scutellariabarbata D. Don extraction (SBE), a traditional Chinese medicine, has been proved effective against various malignant disorders in clinics with tolerable side-effects when administered alone or in combination with conventional chemotherapeutic regimens.Multi-drug resistance of cancer is attributed to existence of cancer stemness-prone cells that harbor aberrantly high activation of Sonic ...
DOI:: 10.1016/j.jep.2020.113295
: https://doi.org/10.1016/j.jep.2020.113295

52. Taraxacum mongolicum extract inhibited malignant phenotype of triple-negative breast cancer cells in tumor-associated macrophages microenvironment through suppressing IL-10 / STAT3 / PD-L1 signaling pathways

Author:: Xin-Xin Deng; Yan-Na Jiao; Hui-Feng Hao; Dong Xue; Chang-Cai Bai; Shu-Yan Han
Source:: Journal of ethnopharmacology 2021 v.274 pp. 113978
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Taraxacum mongolicum; abscess; antineoplastic activity; apoptosis; breast neoplasms; breasts; coculture; flow cytometry; genes; hyperplasia; immunosuppression; interleukin-10; interleukin-4; interleukin-8; macrophages; migratory behavior; phenotype; prognosis; therapeutics; toxicity testing
Abstract:: ... Triple-negative breast cancer (TNBC) is the most aggressive and the worst prognosis breast cancer with limited treatment options. Taraxacum mongolicum (also called dandelion) is a traditional Chinese medicine has been used to treat mastitis, breast abscess, and hyperplasia of mammary glands since ancient times. In modern pharmacological research, dandelion has been proven with anti-breast cancer a ...
DOI:: 10.1016/j.jep.2021.113978
: https://doi.org/10.1016/j.jep.2021.113978

53. Tissue distribution, metabolism and absorption of Rhizoma Paridis Saponins in the rats

Author:: Genbei Wang; Ruijia Hao; Yu Liu; Yu Wang; Shuli Man; Wenyuan Gao
Source:: Journal of ethnopharmacology 2021 v.273 pp. 114038
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; P-glycoproteins; Paris polyphylla var. yunnanensis; absorption; antineoplastic activity; blood serum; brain; diosgenin; liver diseases; lungs; metabolism; oral administration; permeability; rats; spleen; tissue distribution
Abstract:: ... Paris polyphylla var yunnanensis as a traditional Chinese medicine has been used in the treatment of liver disease for thousands of years. Rhizoma Paridis saponins (RPS) were the main active ingredients in Paris polyphylla with an excellent antitumor effect. However, metabolic and distribution of RPS has not been known. Aim of the study: The objective of this study was to research metabolic and di ...
DOI:: 10.1016/j.jep.2021.114038
: https://doi.org/10.1016/j.jep.2021.114038

54. Use Chou's 5-steps rule to study how Baicalin suppresses the malignant phenotypes and induces the apoptosis of colorectal cancer cells

Author:: Wei Zhang; Quanlin Liu; Linshan Luo; Jingfeng Song; Keshun Han; Ruitao Liu; Yuesheng Gong; Xiaoran Guo
Source:: Archives of biochemistry and biophysics 2021 v.705 pp. 108919
ISSN:: 0003-9861
Subject:: Oriental traditional medicine; Scutellaria baicalensis; antineoplastic activity; apoptosis; baicalin; bioinformatics; bioluminescence assay; biophysics; circular RNA; colorectal neoplasms; microRNA; myosin heavy chains; precipitin tests; xenotransplantation
Abstract:: ... Baicalin is a traditional Chinese herb purified from the root of Scutellaria baicalensis Georgi. In this study, we further analyzed the molecular mechanism behind the anti-tumor activity of Baicalin in colorectal cancer (CRC). The establishment of circular RNA (circRNA)/microRNA (miRNA)/messenger RNA (mRNA) axis was predicted by bioinformatic databases and verified by dual-luciferase reporter assa ...
DOI:: 10.1016/j.abb.2021.108919
: https://doi.org/10.1016/j.abb.2021.108919

55. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

Author:: Dou-Dou XU; Xiao-Ying HOU; Ou WANG; Di WANG; Dan-Ting LI; Si-Yuan QIN; Bo LV; Xiao-Min DAI; Zun-Jian ZHANG; Jian-Bo WAN; Feng-Guo XU
Source:: Chinese journal of natural medicines 2021 v.19 no.5 pp. 364-375
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; baicalin; cancer therapy; cell movement; cell proliferation; diarrhea; gastrointestinal system; glycyrrhizin; macrophages; models; toxicity; toxicity testing; xenotransplantation
Abstract:: ... Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to scre ...
DOI:: 10.1016/S1875-5364(21)60034-1
: https://doi.org/10.1016/S1875-5364(21)60034-1

56. An isolated compound from stems and leaves of Coix lacryma-jobi L. and its anticancer effect

Author:: Qiaorong Yu; Guangbin Ye; Zhidong Lei; Ruirui Yang; Ran Chen; Tingting He; Suoyi Huang
Source:: Food bioscience 2021 v.42 pp. 101047
ISSN:: 2212-4292
Subject:: Coix lacryma-jobi; DNA; DNA topoisomerase; Fourier transform infrared spectroscopy; Oriental traditional medicine; active ingredients; antineoplastic activity; apoptosis; molecular weight; neoplasms; nuclear magnetic resonance spectroscopy; rheumatoid arthritis; structure-activity relationships; synthesis; ultraviolet-visible spectroscopy
Abstract:: ... Coix lacryma-jobi L. is a traditional Chinese medicine, and has been investigated to treat inflammatory diseases and rheumatism. An antitumor active compound was isolated from the stems and leaves of Coix lacryma-jobi L. The molecular weight of this compound was 410 using mass spectrum analysis. The structural identification of the purified compound was determined using ultraviolet spectroscopy, F ...
DOI:: 10.1016/j.fbio.2021.101047
: https://doi.org/10.1016/j.fbio.2021.101047

57. A review of Cremastra appendiculata (D.Don) Makino as a traditional herbal medicine and its main components

Author:: Junyu Liu; Chao He; Yan Tang; Wendao Liu; Yi Xu; Zulun Li; Xuhua Qin; Shenrui Jin
Source:: Journal of ethnopharmacology 2021 v.279 pp. 114357
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; abscess; antineoplastic activity; breast neoplasms; colorectal neoplasms; fistula; flavonoids; glycosides; herbal medicines; liver neoplasms; lymph nodes; phenanthrenes; quality control; stomach neoplasms; terpenoids; therapeutics; thyroid neoplasms; China
Abstract:: ... Cremastra appendiculata (D.Don) Makino is a herbal medicine with a medicinal history of more than a thousand years in China. It is traditionally used to treat carbuncle, swelling, abscess, fistula, scrofula and scleroma (related to modern lymph node enlargement and various tumors.).Aim of the review: This paper comprehensively reviewed the botany, traditional application, phytochemistry, pharmacol ...
DOI:: 10.1016/j.jep.2021.114357
: https://doi.org/10.1016/j.jep.2021.114357

58. The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Author:: Zimei Yang; Qiuhua Zhang; Linghong Yu; Jiayan Zhu; Yi Cao; Xiufei Gao
Source:: Journal of ethnopharmacology 2021 v.264 pp. 113249
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; adverse effects; antineoplastic activity; beta catenin; breast neoplasms; databases; drug development; genes; herbal medicines; mechanism of action; metastasis; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; prognosis; protein synthesis; signal transduction
Abstract:: ... Triple-negative breast cancer (TNBC) has a poorer prognosis than other subtypes due to its strong invasion and higher risk of distant metastasis. Traditional Chinese medicine (TCM) and natural medicine have the unique advantages of multitargets and small side-effects and may be used as long-term complementary and alternative therapies.Aim of the review: The present article summarizes the classical ...
DOI:: 10.1016/j.jep.2020.113249
: https://doi.org/10.1016/j.jep.2020.113249

59. An updated review on pharmacological properties of neferine—A bisbenzylisoquinoline alkaloid from Nelumbo nucifera

Author:: Lohanathan Bharathi Priya; Chih‐Yang Huang; Rouh‐Mei Hu; Balamuralikrishnan Balasubramanian; Rathinasamy Baskaran
Source:: Journal of food biochemistry 2021 v.45 no.12 pp. e13986
ISSN:: 0145-8884
Subject:: Nelumbo nucifera; Oriental traditional medicine; antineoplastic activity; antioxidants; apoptosis; arrhythmia; autophagy; biosynthesis; cell cycle checkpoints; central nervous system; chemoprevention; chemosensitization; cisplatin; diabetes; doxorubicin; flavonoids; inflammation; kidneys; myocardium; neurodegenerative diseases; obesity; paclitaxel; pharmacokinetics; platelet aggregation
Abstract:: ... Phytochemicals have recently received a lot of recognition for their pharmacological activities such as anticancer, chemopreventive, and cardioprotective properties. In traditional Indian and Chinese medicine, parts of lotus (Nelumbo nucifera) such as lotus seeds, fruits, stamens, and leaves are used for treating various diseases. Neferine is a bisbenzylisoquinoline alkaloid, a major component fro ...
DOI:: 10.1111/jfbc.13986
: https://doi.org/10.1111/jfbc.13986

60. Actinidia Chinensis Planch Root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting the DLX2/TARBP2/JNK/AKT pathway

Author:: Tingting Fang; Zhiying Zhao; Feifei Yuan; Mingyan He; Jialei Sun; Mengzhou Guo; Peixin Huang; Biwei Yang; Jinglin Xia
Source:: Journal of ethnopharmacology 2020 v.251 pp. 112529
ISSN:: 0378-8741
Subject:: Actinidia chinensis; Oriental traditional medicine; Western blotting; antineoplastic activity; cell lines; cytotoxicity; genes; hepatoma; messenger RNA; metastasis; mitogen-activated protein kinase; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; root extracts; signal transduction; transcription factors
Abstract:: ... Many studies have confirmed that traditional Chinese herbs exert potential anti-tumor effects. Actinidia Chinensis Planch root has been used as a traditional Chinese medicine (TCM) for thousands of years. However, the mechanism of anti-tumor effects of Actinidia Chinensis Planch root has not been clearly clarified.To explore the molecular biological mechanisms underlying the inhibitory effect of A ...
DOI:: 10.1016/j.jep.2019.112529
: https://doi.org/10.1016/j.jep.2019.112529

61. Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation

Author:: Dandan Zhang; Qiao Zhang; Yunliang Zheng; Jincai Lu
Source:: Journal of ethnopharmacology 2020 v.259 pp. 112984
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; cell cycle checkpoints; cytochrome c; cytosol; flow cytometry; fluorescence microscopy; human cell lines; interphase; mechanism of action; mice; mitochondria; oral administration; phosphatidylinositol 3-kinase; rhizomes; staining; toxicity; toxicity testing; triterpenoid saponins
Abstract:: ... The rhizome of Anemone raddeana Regel (A. raddeana) is a famous traditional Chinese medicine (TCM) recorded in Chinese Pharmacopoeia for the treatment of carbuncle and swelling. Carbuncle swollen is an explanation of tumor in the theory of TCM and softening and resolving hard mass effects are one of the important pharmacological activities of A. raddeana.Aim of the study: We investigated the poten ...
DOI:: 10.1016/j.jep.2020.112984
: https://doi.org/10.1016/j.jep.2020.112984

62. Anti-cancer activity of Conyza blinii saponin against cervical carcinoma through MAPK/TGF-β/Nrf2 signaling pathways

Author:: Lei Peng; Chenxi Hu; Chaozheng Zhang; Yingying Lu; Shuli Man; Long Ma
Source:: Journal of ethnopharmacology 2020 v.251 pp. 112503
ISSN:: 0378-8741
Subject:: Conyza; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; blood serum; flow cytometry; genes; human cell lines; inflammation; interleukin-1beta; interleukin-2; luciferase; mice; mitogen-activated protein kinase; neoplasm cells; reactive oxygen species; reverse transcriptase polymerase chain reaction; saponins; signal transduction; transforming growth factor beta; tumor necrosis factor-alpha; uterine cervical neoplasms; China
Abstract:: ... Conyza blinii H.Lév. is a type of natural plant distributed in southwest of China. Its dried overground section can be used in traditional Chinese medicine (TCM) for treating infections, inflammations and occasionally cancers. CBS (Conyza blinii saponin), mainly composed of triterpenoidal saponins of Conyza blinii H.Lév. CBS is considered as the major active fraction of this species. The current i ...
DOI:: 10.1016/j.jep.2019.112503
: https://doi.org/10.1016/j.jep.2019.112503

63. Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: Status and prospect

Author:: Shanshan Li; Yi Sun; Jin Huang; Bin Wang; Yinan Gong; Yuxin Fang; Yangyang Liu; Shenjun Wang; Yi Guo; Hong Wang; Zhifang Xu; Yongming Guo
Source:: Journal of ethnopharmacology 2020 v.258 pp. 112797
ISSN:: 0378-8741
Subject:: Astragalus membranaceus; Oriental traditional medicine; T-lymphocytes; active ingredients; adverse effects; antineoplastic activity; apoptosis; cell lines; drug therapy; herbal medicines; immunosuppression; macrophages; metastasis; models; neoplasm cells; neoplasms; pathophysiology; patients; risk; surgery
Abstract:: ... With cancer deaths increasing, the initiation, pathophysiology and curative management of cancer is receiving increasing attention. Traditional therapies such as surgery and chemoradiotherapy are often accompanied by suppression of host immunity, which increase the risk of metastasis. Astragalus membranceus (AM) is commonly utilized as one herbal medicine of traditional Chinese medicines (TCMs) wi ...
DOI:: 10.1016/j.jep.2020.112797
: https://doi.org/10.1016/j.jep.2020.112797

64. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

Author:: Shuai HUANG; Shuang-Mei ZHAO; Lian-Hai SHAN; Xian-Li ZHOU
Source:: Chinese journal of natural medicines 2020 v.18 no.2 pp. 81-89
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; caspase-9; colorectal neoplasms; human diseases; mitogen-activated protein kinase; neoplasm cells; proteins; pyrrolizidine alkaloids; signal transduction
Abstract:: ... Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with t ...
DOI:: 10.1016/S1875-5364(20)30009-1
: https://doi.org/10.1016/S1875-5364(20)30009-1

65. Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling

Author:: Kuilong Wang; Wei Huang; Xianan Sang; Xin Wu; Qiyuan Shan; Dongxin Tang; Xiaofen Xu; Gang Cao
Source:: Phytomedicine 2020 v.68 pp. 153191
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; cell proliferation; colorectal neoplasms; glucose; glycolysis; in vivo studies; models; neoplasm cells; neoplasm progression; phosphorylation; proteins; reactive oxygen species; signal transduction; stem cells; therapeutics; tissues
Abstract:: ... Atractylenolide I (ATL-1) is a natural herbal compound used in traditional Chinese medicine that has exhibited anti-cancer properties. The anti-tumorigenic activity of ATL-1 against colorectal cancer (CRC) and the underlying signaling pathways involved in its mechanisms are examined here.ATL-1 exerts therapeutic effect against CRC by disrupting glucose metabolism and cancer stem cell maintenance v ...
DOI:: 10.1016/j.phymed.2020.153191
: https://doi.org/10.1016/j.phymed.2020.153191

66. Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives

Author:: Wei-Na Li; Dai-Di Fan
Source:: Applied microbiology and biotechnology 2020 v.104 no.9 pp. 3807-3823
ISSN:: 0175-7598
Subject:: Escherichia coli; GRAS substances; Oriental traditional medicine; Panax ginseng; Saccharomyces cerevisiae; aerobic conditions; antineoplastic activity; antineoplastic agents; biocatalysis; biotransformation; engineering; enzymes; fermentation; food industry; fungi; genes; ginsenosides; health services; industrial applications; moieties; pharmaceutical industry; probiotics; protein engineering; solvents
Abstract:: ... Panax ginseng is a traditional Chinese medicine with significant pharmaceutical effects and broad application. Rare ginsenosides with high antitumor activities can be generated via oriented modification of their glycosyl moiety. For this purpose, suitable microorganisms and their enzymatic systems can be used. In this review, we address several issues associated with these systems. Under aerobic c ...
DOI:: 10.1007/s00253-020-10455-9
: https://doi.org/10.1007/s00253-020-10455-9

67. Cancer cell membrane-camouflaged MOF nanoparticles for a potent dihydroartemisinin-based hepatocellular carcinoma therapy

Author:: Yusha Xiao; Wei Huang; Daoming Zhu; Quanxiong Wang; Baiyang Chen; Zhisu Liu; Yang Wang; Quanyan Liu
Source:: RSC advances 2020 v.10 no.12 pp. 7194-7205
ISSN:: 2046-2069
Subject:: Oriental traditional medicine; adverse effects; antineoplastic activity; antineoplastic agents; biomimetics; cell membranes; coordination polymers; hepatoma; human diseases; ions; iron; models; nanoparticles; neoplasm cells; new drugs; therapeutics; toxicity
Abstract:: ... Developing new drugs for cancer treatment remains a challenging task. Herein, cancer cell membrane biomimetic ferrous ion-doped metal–organic framework nanoparticles (ZIF-8 nanoparticles) combined with dihydroartemisinin (DHA) have been designed for targeted cancer treatment with low toxicity and side effects. The biomimetic nanomaterials (CDZs) have excellent homologous targeting ability and can ...
DOI:: 10.1039/c9ra09233a
: https://doi.org/10.1039/c9ra09233a

68. Caspase 3-mediated cytotoxicity of mealworm larvae (Tenebrio molitor) oil extract against human hepatocellular carcinoma and colorectal adenocarcinoma

Author:: Ricardo A. Wu; Qingzhi Ding; Huijia Lu; Haochen Tan; Nianzhen Sun; Kai Wang; Ronghai He; Lin Luo; Haile Ma; Zhikun Li
Source:: Journal of ethnopharmacology 2020 v.250 pp. 112438
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Tenebrio molitor; adenocarcinoma; antineoplastic activity; apoptosis; cancer therapy; caspases; cytotoxicity; death domain receptors; enzyme activity; fatty acids; flow cytometry; hepatoma; human cell lines; human diseases; inhibitory concentration 50; insect larvae; medicinal insects; neoplasm cells; oils; staining
Abstract:: ... Mealworm larvae (MWL) (Tenebrio molitor) have been traditionally used in Asian countries for the treatment of liver diseases, including cancer. However, to date, there is marginal information on the mechanisms underlying the anticancer activity of MWL oil.This study aims to determine the in vitro effect of MWL oil on human hepatocellular carcinoma (HepG2) and colorectal adenocarcinoma (Caco-2) cel ...
DOI:: 10.1016/j.jep.2019.112438
: https://doi.org/10.1016/j.jep.2019.112438

69. Cell death induction by Ranunculus ternatus extract is independent of mitochondria and dependent on Caspase-7

Author:: Ming Fang; Takahisa Shinomiya; Yukitoshi Nagahara
Source:: 3 Biotech 2020 v.10 no.3 pp. 123
ISSN:: 2190-572X
Subject:: DNA fragmentation; Oriental traditional medicine; Ranunculus; T-cell lymphoma; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; caspase-7; cytotoxicity; enzyme inhibitors; ethyl acetate; human cell lines; humans; mitochondria; phosphatidylserines; toxicity testing
Abstract:: ... Ranunculus ternatus is a traditional Chinese medicine with an anticancer effect, but its underlying mechanism is unknown. In this study, we demonstrated by MTT assay that ethyl acetate extract (RTE) from R. ternatus exerts cytotoxic effects on human T cell lymphoma Jurkat cells. Then, to test the apoptosis induction ability of RTE to induce apoptosis, we analyzed phosphatidylserine exposure, DNA f ...
DOI:: 10.1007/s13205-020-2111-z
PubMed:: 32123647
PubMed Central:: PMC7026323
: https://doi.org/10.1007/s13205-020-2111-z

70. Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity

Author:: Bayarma M. Urbagarova; Elvira E. Shults; Vasilii V. Taraskin; Larisa D. Radnaeva; Tatyana N. Petrova; Tatyana V. Rybalova; Tatyana S. Frolova; Andrey G. Pokrovskii; Jamsranjav Ganbaatar
Source:: Journal of ethnopharmacology 2020 v.261 pp. 112517
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Saposhnikovia divaricata; X-ray diffraction; antineoplastic activity; antineoplastic agents; antioxidants; bergapten; cell lines; chemical composition; chemical constituents of plants; cytotoxicity; ethanol; ethyl acetate; ethyl ether; fractionation; glycosides; hemolysis; high performance liquid chromatography; homeopathic drugs; medicinal plants; models; neoplasm cells; neoplasms; petroleum; roots; scopoletin; silica gel; therapeutics; China; Mongolia; Siberia
Abstract:: ... Saposhnikovia divaricata (family Apiaceae) a traditional medicinal plant distributed in many provinces of China, is well known for the pharmaceutical value and has been used for rheumatic arthritis, and anxiety in children. Antiviral, antioxidant and antiproliferative activities were also mentioned. The application of this plant are recorded in the Chinese Medicine (CM) classical text the Shen Non ...
DOI:: 10.1016/j.jep.2019.112517
: https://doi.org/10.1016/j.jep.2019.112517

71. Effects of herbal and mushroom formulations used in Traditional Chinese Medicine on in vitro human cancer cell lines at the preclinical level: An empirical review of the cell killing mechanisms

Author:: Qiulan Wu; Tingting Dai; Jie Song; Xiaorong Liu; Shaomin Song; Lili Li; Jingbing Liu; Arivalagan Pugazhendhi; Joe Antony Jacob
Source:: Process biochemistry 2020 v.94 pp. 136-142
ISSN:: 1359-5113
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; herbal medicines; human cell lines; human diseases; mushrooms; neoplasm cells; neoplasms
Abstract:: ... Traditional Chinese Medicine (TCM), a long-established method for treating various types of cancers using various forms of herbal medicine has recently received the wide-acclaim for its beneficiary effects. Although the scientific proof for such medicine was limited several decades ago, recent research evidences have been supportive for this type of medicine. Chinese medicine can have several bene ...
DOI:: 10.1016/j.procbio.2020.04.019
: https://doi.org/10.1016/j.procbio.2020.04.019

72. Enhanced anticancer efficacy of cantharidin by mPEG-PLGA micellar encapsulation: An effective strategy for application of a poisonous traditional Chinese medicine

Author:: Hailu Yao; Junli Zhao; Zhen Wang; Jinwei Lv; Gangjun Du; Yiguang Jin; Yu Zhang; Shiyong Song; Guang Han
Source:: Colloids and surfaces 2020 v.196 pp. 111285
ISSN:: 0927-7765
Subject:: Mylabris; Oriental traditional medicine; antineoplastic activity; apoptosis; biocompatibility; cantharidin; drugs; encapsulation; half life; hepatocytes; hepatoma; intravenous injection; kidneys; micelles; particle size; permeability; toxicity; zeta potential
Abstract:: ... Cantharidin (CTD), the main active component of a poisonous traditional Chinese medicine (PTCM) Mylabris, exhibits highly effective therapy of hepatocellular carcinoma (HCC); however, the severe toxicity of CTD on the digestive and urinary systems prevents its clinical application. Here, CTD-loaded micelles (mPEG-PLGA-CTD) were prepared for enhancement of the antitumor efficacy and reduction of th ...
DOI:: 10.1016/j.colsurfb.2020.111285
: https://doi.org/10.1016/j.colsurfb.2020.111285

73. Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism

Author:: Yu Jiang; Liuping Fan
Source:: Journal of ethnopharmacology 2020 v.257 pp. 112851
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Wolfiporia cocos; active ingredients; adverse effects; antineoplastic activity; apoptosis; breast neoplasms; breasts; caspase-3; cell cycle checkpoints; cell growth; cell viability; chromatography; cisplatin; cyclin-dependent kinase; cyclins; cytochrome c; cytotoxicity; death; dose response; edible fungi; epithelium; ethanol; flow cytometry; hyperplasia; in vitro studies; in vivo studies; inhibitory concentration 50; interphase; mammary glands; mice; models; muscle strength; neoplasm cells; pro-apoptotic proteins; protein content; spectral analysis; viability assays
Abstract:: ... Poria cocos Wolf (P. cocos), a well-known traditional East-Asian medicinal and edible fungus, is one of the most important components in Chinese medicine formulas like “Guizhi fuling wan” to treat hyperplasia of mammary glands and breast cancer.In this study, we attempted to verify the anticancer efficacy of the ethanol extract of P. cocos (PC) on the breast cancer as well as to investigate its mo ...
DOI:: 10.1016/j.jep.2020.112851
: https://doi.org/10.1016/j.jep.2020.112851

74. Evaluation of biosynthesis parameters, stability and biological activities of silver nanoparticles synthesized by Cornus Officinalis extract under 365 nm UV radiation

Author:: Yinghui Wang; Simin Wei; Kang Wang; Zhe Wang; Jinwei Duan; Lin Cui; Huayu Zheng; Ying Wang; Shanshan Wang
Source:: RSC advances 2020 v.10 no.45 pp. 27173-27182
ISSN:: 2046-2069
Subject:: Cornus officinalis; Escherichia coli; Oriental traditional medicine; Staphylococcus aureus; X-ray diffraction; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bacteria; biosynthesis; cytotoxicity; flow cytometry; human cell lines; light scattering; nanoparticles; nanosilver; pH; particle size; phytochemicals; plant extracts; silver nitrate; transmission electron microscopy; ultraviolet radiation; zeta potential
Abstract:: ... Since silver nanoparticles (AgNPs) synthesized by using plant extracts revealed varied biological activities, the green synthesis of AgNPs has attracted considerable attention. Although the green synthesis of AgNPs have been accomplished by using the extracts of Cornus Officinalis, which is a traditional Chinese medicine and exhibits a wide spectrum of phytochemicals. The effects of biosynthesis p ...
DOI:: 10.1039/d0ra04482b
: https://doi.org/10.1039/d0ra04482b

75. Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases

Author:: Xiaojiaoyang Li; Junde Ge; Qi Zheng; Jiaxiang Zhang; Rong Sun; Runping Liu
Source:: Phytomedicine 2020 v.68 pp. 153180
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; Tetradium ruticarpum; alkaloids; antineoplastic activity; blood proteins; databases; essential oils; glucose; hepatoprotective effect; herbal medicines; homeostasis; ingredients; lipids; liver; liver diseases; morbidity; mortality; pharmacokinetics; phenols; protein synthesis; public health; roots; saponins; secretion; therapeutics; toxicology; xenobiotics
Abstract:: ... Liver is the pivotal organ responsible for plasma protein production, biliary secretion, xenobiotic elimination, glucose and lipid homeostasis. Dysregulation of these functions usually leads to liver diseases and further related complications. The incidence of liver diseases is increasing worldwide, with high morbidity and mortality when at advanced stages, and has become significant public health ...
DOI:: 10.1016/j.phymed.2020.153180
: https://doi.org/10.1016/j.phymed.2020.153180

76. First Report of Colletotrichum gloeosporioides Causing Leaf Spots on Rubia cordifolia in Qingdao, China

Author:: Si-Fu Tang; Ling-Ling Tan
Source:: Plant disease 2020 v.104 no.10 pp. 2733
ISSN:: 0191-2917
Subject:: Glomerella cingulata; Oriental traditional medicine; Rubia cordifolia; actin; antineoplastic activity; calmodulin; chitin synthase; conidia; culture media; ethanol; fungi; glyceraldehyde-3-phosphate dehydrogenase; greenhouses; herbal medicines; hyphae; internal transcribed spacers; leaf spot; pathogenicity; petioles; plastic bags; relative humidity; ribosomal DNA; tubulin; China
Abstract:: ... As an important herbal medicine, the root of Rubia cordifolia L., commonly known as madder, has been extensively used to treat several illnesses in Chinese medicine (Chandrashekar et al. 2018). Several extracts from its root were identified to have anticancer properties (Jong et al. 2008). Madders are usually produced in fields in Qingdao, China. Approximately 15% of madder leaves were observed wi ...
DOI:: 10.1094/PDIS-02-20-0292-PDN
: https://doi.org/10.1094/PDIS-02-20-0292-PDN

77. Genomic data mining approaches for the discovery of anticancer peptides from Ganoderma sinense

Author:: Sheng Zheng; Ning Zhu; Cheng Shi; Heng Zheng
Source:: Phytochemistry 2020 v.179 pp. 112466
ISSN:: 0031-9422
Subject:: Ganoderma; Oriental traditional medicine; active ingredients; antineoplastic activity; computer simulation; data analysis; digestion; drugs; extraction; genome mining; longevity; mushrooms; peptides; plant biochemistry; polysaccharides; proteins; proteome; proteomics; research; sequence homology; trypsin
Abstract:: ... Drug discovery from traditional Chinese medicine (TCM) typically involves the extraction of active ingredients from natural products with high biological activity and function from the vast repertoire of traditional Chinese medicine. This strategy cannot fully exploit the vast resources of TCM. Known as the longevity mushroom, Ganoderma spp. has been used as medicine for thousands of years. Recent ...
DOI:: 10.1016/j.phytochem.2020.112466
: https://doi.org/10.1016/j.phytochem.2020.112466

78. Ginsenoside Rh2 induces DNA damage and autophagy in vestibular schwannoma is dependent of LAMP2 transcriptional suppression

Author:: Dong Yang; Xin Li; Xiaoyan Zhang
Source:: Biochemical and biophysical research communications 2020 v.522 no.2 pp. 300-307
ISSN:: 0006-291X
Subject:: DNA damage; Oriental traditional medicine; Panax; adjuvants; antineoplastic activity; apoptosis; autophagy; ginsenosides; humans; membrane proteins; neoplasms; research; therapeutics; transcription (genetics); viability
Abstract:: ... Ginsenoside Rh2 (G-Rh2), a component of ginseng extraction, exerted anti-tumor property in the occurrence and progress of human tumors. Vestibular schwannoma (VS) is a kind of benign tumor. Extraction of traditional Chinese herb has been applied to treat VS as adjuvant therapy. Nevertheless, G-Rh2-related molecular mechanisms in VS progress are not yet clear. The purpose of current study is to unv ...
DOI:: 10.1016/j.bbrc.2019.11.026
: https://doi.org/10.1016/j.bbrc.2019.11.026

79. Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells

Author:: Jinghui Zhang; Yanjun Hong; Lilong Jiang; Xiaojiao Yi; Yang Chen; Li Liu; Zhongjian Chen; Yongjiang Wu; Zongwei Cai
Source:: Journal of proteome research 2020 v.19 no.2 pp. 873-883
ISSN:: 1535-3907
Subject:: Bufo bufo; Oriental traditional medicine; active ingredients; amino acid metabolism; antineoplastic activity; apoptosis; biochemical pathways; cell cycle checkpoints; energy metabolism; hepatoma; human cell lines; lipid metabolism; liquid chromatography; mass spectrometry; metabolomics; methionine; proteome; secretion; synergism; therapeutics; toads
Abstract:: ... Chansu, which is prepared from the skin secretions of toad (Bufo bufo gargarizans Cantor), is widely used in traditional Chinese medicine (TCM). Being the principal bioactive constituents of Chansu, bufalin (BFL) and cinobufagin (CBF) have been shown to possess anticancer properties. TCM confers bioactivities through the synergistic effect between potential active ingredients, so as to interfere w ...
DOI:: 10.1021/acs.jproteome.9b00681
: https://doi.org/10.1021/acs.jproteome.9b00681

80. Haimufang decoction, a Chinese medicine formula for lung cancer, arrests cell cycle, stimulates apoptosis in NCI-H1975 cells, and induces M1 polarization in RAW 264.7 macrophage cells

Author:: Wei-Ping Ma; Shu-Man Hu; Yan-Lai Xu; Hai-Hua Li; Xiao-Qing Ma; Bao-Hong Wei; Fu-Yu Li; Hua-Shi Guan; Guang-Li Yu; Ming Liu; Hong-Bing Liu
Source:: BMC complementary medicine and therapies 2020 v.20 no.1 pp. 243
ISSN:: 2662-7671
Subject:: Oriental traditional medicine; alternative medicine; antineoplastic activity; apoptosis; cancer therapy; cell cycle checkpoints; coculture; cytotoxicity; enzymes; flow cytometry; fluorescent antibody technique; humans; immunomodulation; immunomodulators; interleukin-12; interleukin-6; interphase; lung neoplasms; macrophage activation; macrophages; monocytes; morbidity; mortality; necrosis; nitric oxide; patents; phagocytosis; phenotype; reactive oxygen species
Abstract:: ... BACKGROUND: Lung cancer has the highest morbidity and mortality in the world and novel treatment strategies are still needed. Haimufang decoction (HMF) is a patented clinical prescription of traditional Chinese medicine for lung cancer treatment. HMF is composed of four herbs and has been applied clinically in advanced cancer patients. However, its therapeutic mechanisms are still unclear. This st ...
DOI:: 10.1186/s12906-020-03031-1
: https://doi.org/10.1186/s12906-020-03031-1

81. Identification of cytochrome P450 isoenzymes involved in the metabolism of 23-hydroxybetulinic acid in human liver microsomes

Author:: Ying Zhou; Jinhua Wen; Guangji Wang
Source:: Pharmaceutical biology 2020 v.58 no.1 pp. 60-63
ISSN:: 1744-5116
Subject:: Anemone chinensis; Oriental traditional medicine; antineoplastic activity; cytochrome P-450; humans; isozymes; ketoconazole; liver microsomes; pharmacokinetics; quinidine
Abstract:: ... 23-Hydroxybetulinic acid (23-HBA), a major active constituent of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), exhibits potential antitumor activity. Its metabolism, however, has not yet been studied. This study focuses on the metabolism of 23-HBA in vitro by human liver microsomes. The metabolic kinetics of 23-HBA (0.5–100 µM) and the effects of selective CYP450 (CYP1A2, CYP2C9, CYP2C19, CY ...
DOI:: 10.1080/13880209.2019.1701500
: https://doi.org/10.1080/13880209.2019.1701500

82. Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway

Author:: Jia Jia; Xigang Kang; Yanfang Liu; Jianwei Zhang
Source:: Applied biological chemistry 2020 v.63 no.1 pp. 67
ISSN:: 2468-0834
Subject:: 4',6-diamidino-2-phenylindole; Euodia; Oriental traditional medicine; alkaloids; antineoplastic activity; apoptosis; assays; cell growth; cell lines; cell movement; cytotoxicity; decline; exhibitions; humans; liver neoplasms; neoplasm cells; phosphatidylinositol 3-kinase; phosphorylation; proteins; staining; therapeutics; tissue repair
Abstract:: ... Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptos ...
DOI:: 10.1186/s13765-020-00551-9
: https://doi.org/10.1186/s13765-020-00551-9

83. Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach

Author:: Biting Wang; Zengrui Wu; Jiye Wang; Weihua Li; Guixia Liu; Bo Zhang; Yun Tang
Source:: BMC complementary medicine and therapies 2020 v.20 no.1 pp. 322
ISSN:: 2662-7671
Subject:: Arnebia euchroma; Gibbs free energy; Oriental traditional medicine; T-lymphocytes; alternative medicine; angiogenesis; antineoplastic activity; apoptosis; cell viability; interleukin-17; leukemia; mechanism of action; neoplasm cells; shikonin
Abstract:: ... BACKGROUND: Arnebia euchroma (A. euchroma) is a traditional Chinese medicine (TCM) used for the treatment of blood diseases including leukemia. In recent years, many studies have been conducted on the anti-tumor effect of shikonin and its derivatives, the major active components of A. euchroma. However, the underlying mechanism of action (MoA) for all the components of A. euchroma on leukemia has ...
DOI:: 10.1186/s12906-020-03106-z
: https://doi.org/10.1186/s12906-020-03106-z

84. Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control

Author:: Xiang Zhan; Huan Wu; Hong Wu; Rong Wang; Chuan Luo; Bo Gao; Zhiwu Chen; Qinglin Li
Source:: Journal of ethnopharmacology 2020 v.246 pp. 112178
ISSN:: 0378-8741
Subject:: Bufo; Oriental traditional medicine; active ingredients; analgesia; analytical methods; animals; antineoplastic activity; bufadienolides; cardiotoxicity; databases; drugs; enzymes; guidelines; immunomodulation; indole alkaloids; metabolites; models; pain; quality control; sodium; threatened species; toxicity; China
Abstract:: ... Bufo gargarizans (Cantor, 1842) (BGC), a traditional medicinal animal distributed in many provinces of China, is well known for the pharmaceutical value of Chansu and Chanpi. As traditional Chinese medicines (TCMs), Chansu and Chanpi, with their broad-spectrum of therapeutic applications, have long been applied to detoxification, anti-inflammation, analgesia, etc.We critically analyzed the current ...
DOI:: 10.1016/j.jep.2019.112178
: https://doi.org/10.1016/j.jep.2019.112178

85. Moderate drought followed by re-watering initiates beneficial changes in the photosynthesis, biomass production and Rubiaceae-type cyclopeptides (RAs) accumulation of Rubia yunnanensis

Author:: Yuanyuan Miao; Qirui Bi; Hui Qin; Xuejia Zhang; Ninghua Tan
Source:: Industrial crops and products 2020 v.148 pp. 112284
ISSN:: 0926-6690
Subject:: Oriental traditional medicine; Rubia; antineoplastic activity; biomass production; chlorophyll; drought; electron transfer; energy conversion; photochemistry; photosystem II; pigments; rhizomes; roots; secondary metabolites; water management
Abstract:: ... Roots and rhizomes of Rubia yunnanensis are important Chinese medicine materials with significant anti-tumor activity, which is mainly obtained from wild resources. There is an urgent need to develop the production practice for the cultivation of R. yunnanensis. The current study was performed to investigate the changes in the photosynthetic pigment content, photosynthetic characteristics, chlorop ...
DOI:: 10.1016/j.indcrop.2020.112284
: https://doi.org/10.1016/j.indcrop.2020.112284

86. Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress

Author:: Chunyang Yi; Xiaolong Li; Si Chen; Mingyao Liu; Weiqiang Lu; Xiyun Ye
Source:: Phytotherapy research 2020 v.34 no.10 pp. 2766-2777
ISSN:: 0951-418X
Subject:: Corydalis; DNA damage; Oriental traditional medicine; antineoplastic activity; apoptosis; caspase-3; cell cycle; cell growth; cells; cysteine; melanoma; oxidative stress; patients; phytotherapy; reactive oxygen species; research
Abstract:: ... Natural product corynoline is a unique isoquinoline alkaloid extracted from traditional Chinese medicine Corydalis bungeana Turcz, whereas its anticancer properties have not been investigated. In this study, we found that corynoline potently impairs the growth of melanoma cells, B16F10, and A375 in a concentration‐dependent manner. Treatment of melanoma cells with corynoline results in G2 cell arr ...
DOI:: 10.1002/ptr.6719
: https://doi.org/10.1002/ptr.6719

87. Nitric oxide, a communicator between tumor cells and endothelial cells, mediates the anti-tumor effects of Marsdenia Tenacissima Extract (MTE)

Author:: Zhandong Li; Huifeng Hao; Wenjia Tian; Yanna Jiao; Xinxin Deng; Shuyan Han; Jingyan Han
Source:: Journal of ethnopharmacology 2020 v.250 pp. 112524
ISSN:: 0378-8741
Subject:: Marsdenia tenacissima; Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; cell viability; coculture; endothelial cells; endothelial nitric oxide synthase; lung neoplasms; lungs; mice; models; neoplasm cells; nitric oxide; oral administration; plant extracts; signal transduction; water solubility
Abstract:: ... Marsdenia tenacissima (Roxb.) Wight & Arn is a well-known traditional Chinese medicine for treating cancer. The anti-tumor effects of the water soluble component of M. tenacissima (MTE, M. Tenacissima Extract) have been intensely studied. However, the roles of microenvironmental cells in mediating the anti-tumor actions of MTE remain to be defined.To determine the roles of nitric oxide (NO) releas ...
DOI:: 10.1016/j.jep.2019.112524
: https://doi.org/10.1016/j.jep.2019.112524

88. Prediction of the mechanisms of Xiaoai Jiedu Recipe in the treatment of breast cancer: A comprehensive approach study with experimental validation

Author:: Yuyun Li; Rang Li; Zhanwei Zeng; Siyan Li; Shiying Luo; Jiahuan Wu; Chenhui Zhou; Daohua Xu
Source:: Journal of ethnopharmacology 2020 v.252 pp. 112603
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; active ingredients; antineoplastic activity; apoptosis; bioactive compounds; bioinformatics; breast neoplasms; chronic diseases; drugs; gene expression regulation; genes; herbs; in vitro studies; membrane potential; mitochondrial membrane; neoplasm cells; pharmacodynamics; prediction; quercetin; screening; signal transduction; therapeutics; ursolic acid
Abstract:: ... Traditional Chinese medicine (TCM) holds a great promise for preventing complex chronic diseases through a holistic way. Certain Chinese medicine formulae from TCM are effective for treating and preventing cancer in clinical practice. Xiaoai Jiedu Recipe (XJR) is a Chinese medicine formula that has been used to treat breast cancer (BC). However, its active ingredients and therapeutic mechanisms on ...
DOI:: 10.1016/j.jep.2020.112603
: https://doi.org/10.1016/j.jep.2020.112603

89. Recent progress in the research of yam mucilage polysaccharides: Isolation, structure and bioactivities

Author:: Rong Huang; Jianhua Xie; Yue Yu; Mingyue Shen
Source:: International journal of biological macromolecules 2020 v.155 pp. 1262-1269
ISSN:: 0141-8130
Subject:: Dioscorea polystachya; Oriental traditional medicine; antineoplastic activity; asthma; bioactive compounds; diabetes; diarrhea; functional foods; hypoglycemia; mucilages; plant biochemistry; raw materials; tubers; yams; China
Abstract:: ... Yam (Dioscorea spp.), known as an edible and medicinal tuber crop in China, has been used historically for the treatment of diabetes, diarrhea, asthma, and other ailments in traditional Chinese medicine. Moreover, it has been consumed as starchy food for thousands of years in China. Modern phytochemistry and pharmacological experiments have been proved that non-starch polysaccharide is one of the ...
DOI:: 10.1016/j.ijbiomac.2019.11.095
: https://doi.org/10.1016/j.ijbiomac.2019.11.095

90. Rhinacanthus nasutus “Tea” Infusions and the Medicinal Benefits of the Constituent Phytochemicals

Author:: James Michael Brimson; Mani Iyer Prasanth; Dicson Sheeja Malar; Sirikalaya Brimson; Tewin Tencomnao
Source:: Nutrients 2020 v.12 no.12 pp. -
ISSN:: 2072-6643
Subject:: Oriental traditional medicine; Rhinacanthus nasutus; antineoplastic activity; blood pressure; diabetes; eczema; gastritis; infection; phytochemicals; research; ringworm; shrubs; snakes; tea; tuberculosis; Thailand
Abstract:: ... Rhinacanthus nasutus (L.) Kurz (Acanthaceae) (Rn) is an herbaceous shrub native to Thailand and much of South and Southeast Asia. It has several synonyms and local or common names. The root of Rn is used in Thai traditional medicine to treat snake bites, and the roots and/or leaves can be made into a balm and applied to the skin for the treatment of skin infections such as ringworm, or they may be ...
DOI:: 10.3390/nu12123776
: https://doi.org/10.3390/nu12123776

91. Rumex japonicus Houtt.: A phytochemical, pharmacological, and pharmacokinetic review

Author:: Yue Sun; George B. Lenon; Angela W. H. Yang
Source:: Phytotherapy research 2020 v.34 no.6 pp. 1198-1215
ISSN:: 0951-418X
Subject:: Oriental traditional medicine; Rumex; antineoplastic activity; antioxidants; cinnamic acid; databases; emodin; flavonoids; glycemic effect; glycosides; infrastructure; knowledge; pharmacokinetics; phenolic acids; phytosterols; phytotherapy; research; toxicity; triterpenoids; China
Abstract:: ... Rumex japonicus Houtt. (RJH‐Yang Ti) RJH has been used as a folk medicine in East Asian countries for thousands of years. It has a wide range of therapeutic effects in terms of anti‐microorganic, anti‐oxidant, anti‐inflammatory, and antitumor effects. Therefore, it is urgent to thoroughly review the existing knowledge for this herb from phytochemical, pharmacological, and pharmacokinetic perspecti ...
DOI:: 10.1002/ptr.6601
: https://doi.org/10.1002/ptr.6601

92. Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review

Author:: Ruizhou Wang; Xinxin Deng; Qixia Gao; Xiuli Wu; Lu Han; Xiaojuan Gao; Shipeng Zhao; Weibin Chen; Rongrong Zhou; Zhiyong Li; Changcai Bai
Source:: Journal of ethnopharmacology 2020 v.248 pp. 112172
ISSN:: 0378-8741
Subject:: Internet; Oriental traditional medicine; Sophora alopecuroides; alkaloids; analgesics; antineoplastic activity; bacterial infections; chronic diseases; databases; drug development; fever; fibroblasts; fibrosis; flavonoids; flora; gastrointestinal system; heart diseases; hepatitis B; inflammation; medicinal plants; neoplasms; new drugs; polysaccharides; quality control; rheumatoid arthritis; steroids; therapeutics; toxicity; toxicology; Central Asia; China
Abstract:: ... Sophora alopecuroides L., which is called Kudouzi in China, is a medicinal plant distributed in Western and Central Asia, especially in China, and has been used for decades to treat fever, bacterial infection, heart disease, rheumatism, and gastrointestinal diseases.This review aims to provide up-to-date information on S. alopecuroides, including its botanical characterization, medicinal resources ...
DOI:: 10.1016/j.jep.2019.112172
: https://doi.org/10.1016/j.jep.2019.112172

93. Spectrum-effect relationship for anti-tumor activity of shikonins and shikonofurans in medicinal Zicao by UHPLC-MS/MS and chemometric approaches

Author:: Mei Liao; Pan Yan; Xuechen Liu; Zhifeng Du; Shuailong Jia; Rahmetulla Aybek; Aiqian Li; Sulaiman Kaisa; Hongliang Jiang
Source:: Journal of chromatography 2020 v.1136 pp. 121924
ISSN:: 1570-0232
Subject:: Arnebia euchroma; Arnebia guttata; Lithospermum erythrorhizon; Oriental traditional medicine; active ingredients; antineoplastic activity; bioactive compounds; chemometrics; high performance liquid chromatography; human cell lines; least squares; monitoring; roots; shikonin; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... Shikonin, shikonofuran and their derivatives are the main bioactive components of Zicao, a traditional Chinese medicine prepared with the dried roots of Lithospermum erythrorhizon, Arnebia euchroma or Arnebia guttata. To establish an efficient and sensitive method for studying material basis of Zicao, different scan modes of ultra-high performance liquid chromatography quadrupole time of flight ta ...
DOI:: 10.1016/j.jchromb.2019.121924
: https://doi.org/10.1016/j.jchromb.2019.121924

94. Structural characterization of centipede cyclic peptides and apoptosis induction potency evaluation in human gastric cancer cells

Author:: Feng Wang; Wei Li; Xiaolei Liu; Hongpeng Zhao; Jie Liu
Source:: Phytochemistry letters 2020 v.40 pp. 156-165
ISSN:: 1874-3900
Subject:: Chilopoda; Oriental traditional medicine; antineoplastic activity; apoptosis; caspases; cell cycle; cell lines; cyclic peptides; cytotoxicity; humans; membrane potential; mitochondrial membrane; neoplasm cells; plant biochemistry; stomach neoplasms; therapeutics; thioredoxins; toxicity testing
Abstract:: ... Centipede is a traditional Chinese medicine preparation widely used for gastrointestinal cancers. In this study, the structures of four novel and sixteen known centipede cyclic peptides (CCPs) were identified and their antigastrointestinal cancer potency elucidated. MTT assay demonstrated that CCP-1 [Cyclo-(L-Lys-L-His-L-Leu-L-Trp)] had excellent antitumor activity against the human tumor cell lin ...
DOI:: 10.1016/j.phytol.2020.09.015
: https://doi.org/10.1016/j.phytol.2020.09.015

95. Systems pharmacology unravels the synergic target space and therapeutic potential of Rhodiola rosea L. for non-small cell lung cancer

Author:: Xia Zhang; Jinglin Zhu; Jiangna Yan; Yue Xiao; Ruijie Yang; Ruifei Huang; Jun Zhou; Zhenzhong Wang; Wei Xiao; Chunli Zheng; Yonghua Wang
Source:: Phytomedicine 2020 v.79 pp. 153326
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; Rhodiola rosea; Western blotting; angiogenesis; antineoplastic activity; apoptosis; cancer therapy; cell proliferation; computer simulation; flow cytometry; inflammation; lung neoplasms; mechanism of action; pharmacokinetics; prediction; pro-apoptotic proteins; salidroside
Abstract:: ... Lung cancer is the most common and mortal cancer worldwide. Rhodiola rosea L. (RR), a well-known traditional Chinese medicine (TCM), has been turned out to be effective in anti-lung cancer therapy, but its molecular mechanism of action has not been clearly understood.In this study, we aimed to elucidate the possible molecular mechanism underlying the effect of RR against non-small cell lung cancer ...
DOI:: 10.1016/j.phymed.2020.153326
: https://doi.org/10.1016/j.phymed.2020.153326

96. Tripterygium glycoside fraction n2 ameliorates adriamycin-induced nephrotic syndrome in rats by suppressing apoptosis

Author:: Xiao-wan Wang; Rui-min Tian; Yi-qi Yang; Kai Wang; En-nian Li; Xiao-dong Han; Kun Bao; Wei Mao; Hong-tao Xu; Bo Liu; Peng Xu
Source:: Journal of ethnopharmacology 2020 v.257 pp. 112789
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Tripterygium wilfordii; Western blotting; animal models; antineoplastic activity; apoptosis; caspase-12; caspase-3; caspase-8; caspase-9; chromium; doxorubicin; electron microscopy; enzyme activity; fluorescence microscopy; glycosides; histopathology; immunosuppression; intravenous injection; kidneys; nephrotic syndrome; protective effect; protein content; protein synthesis; proteinuria; rats; renal function; renoprotective effect; staining; tissues; toxicity
Abstract:: ... Tripterygium wilfordii Hook F. (TwHF), a traditional Chinese herb medicine, has been widely used for clinical treatment of various rheumatic immune diseases. Tripterygium glycosides (TG) extracted from TwHF has been verified to process multiple bioactivities, including immunosuppressive, anti-inflammatory and anti-cancer effects. However, the clinical application of TG is limited due to its severe ...
DOI:: 10.1016/j.jep.2020.112789
: https://doi.org/10.1016/j.jep.2020.112789

97. Triterpenoids Extracted from Rhus chinensis Mill Act Against Colorectal Cancer by Inhibiting Enzymes in Glycolysis and Glutaminolysis: Network Analysis and Experimental Validation

Author:: Gang Wang; Yu-Zhu Wang; Yang Yu; Jun-Jie Wang; Pei-Hao Yin; Ke Xu
Source:: Nutrition and cancer 2020 v.72 no.2 pp. 293-319
ISSN:: 1532-7914
Subject:: Oriental traditional medicine; Rhus; Western blotting; active ingredients; antineoplastic activity; apoptosis; biochemical pathways; cell proliferation; colorectal neoplasms; enzyme inhibition; enzymes; experimental design; flavonoids; glycolysis; mass spectrometry; metabolomics; neoplasm cells; proteins; quantitative analysis; triterpenoids; ultra-performance liquid chromatography
Abstract:: ... Background: Rhus chinensis Mill is a traditional Chinese medicine (TCM) mostly used to treat several cancer types. Although previous studies have found that certain ingredients of R. chinensis such as flavonoids can inhibit tumor cell proliferation [e.g. colorectal cancer (CRC)], systematic research on the mechanism underlying anticancer effect of active compounds like triterpenoids (TER) is lacki ...
DOI:: 10.1080/01635581.2019.1631858
: https://doi.org/10.1080/01635581.2019.1631858

98. A UPLC-Q-TOF/MS-based plasma metabolomics approach reveals the mechanism of Compound Kushen Injection-based intervention against non-small cell lung cancer in Lewis tumor-bearing mice

Author:: Huan Wu; Lina Wang; Xiang Zhan; Bin Wang; Jiawen Wu; An Zhou
Source:: Phytomedicine 2020 v.76 pp. 153259
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; amino acid metabolism; antineoplastic activity; apoptosis; biochemical pathways; biomarkers; biosynthesis; cytidine; dyes; glycerophospholipids; histopathology; lung neoplasms; lysophospholipids; mass spectrometry; metabolomics; multivariate analysis; phospholipase A2; sarcoma; sphingolipids; therapeutics; ultra-performance liquid chromatography; viability
Abstract:: ... Compound Kushen Injection (CKI), a well-known Chinese Medicine preparation, has been used to treat non-small cell lung cancer (NSCLC) for more than 15 years, and its clinical curative effect is considered to be beneficial.This study was designed to evaluate the effects and underlying mechanisms of CKI against NSCLC using an ultra-high-performance liquid chromatography quadrupole time-of-flight mas ...
DOI:: 10.1016/j.phymed.2020.153259
: https://doi.org/10.1016/j.phymed.2020.153259

99. Unripe Black Raspberry (Rubus coreanus Miquel) Extract and Its Constitute, Ellagic Acid Induces T Cell Activation and Antitumor Immunity by Blocking PD-1/PD-L1 Interaction

Author:: Ji Hye Kim; Young Soo Kim; Tae In Kim; Wei Li; Jeong-Geon Mun; Hee Dong Jeon; Ji-Ye Kee; Jang-Gi Choi; Hwan-Suck Chung
Source:: Foods 2020 v.9 no.11 pp. -
ISSN:: 2304-8158
Subject:: Oriental traditional medicine; Rubus coreanus; Rubus occidentalis; T-lymphocytes; antibodies; antineoplastic activity; binding properties; coculture; colorectal neoplasms; ellagic acid; enzyme-linked immunosorbent assay; foods; fruits; immunity; immunotherapy; mice; models; oral administration; East Asia
Abstract:: ... Rubus coreanus Miquel (R. coreanus) is a unripen fruit of black raspberry native to eastern Asia. It is used as traditional oriental medicine and supplementary foods for centuries. Previous studies have shown that the R. coreanus extract (RCE) and its main constitute ellagic acid possess diverse biological activities. However, the effects of RCE on antitumor immunity and T cell function were not f ...
DOI:: 10.3390/foods9111590
: https://doi.org/10.3390/foods9111590

100. Xihuang pill potentiates the anti-tumor effects of temozolomide in glioblastoma xenografts through the Akt/mTOR-dependent pathway

Author:: Jin Fu; Shi-Hui Zhu; Hong-Bin Xu; You-Qi Xu; Xia Wang; Juan Wang; Ping-Shi Kong
Source:: Journal of ethnopharmacology 2020 v.261 pp. 113071
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; cell proliferation; glioblastoma; immunocytochemistry; models; neoplasm cells; proliferating cell nuclear antigen; signal transduction; xenotransplantation; China
Abstract:: ... Xihuang pill, as a famous traditional Chinese medicine formula, is used for tumor treatment in China. The anti-tumor activities and mechanisms of Xihuang pill still remain unclear.The Akt/mTOR signaling pathway plays an important role in mediating cell proliferation and apoptosis in glioblastoma. This study aimed to investigate whether Xihuang pill could potentiate temozolomide-induced apoptosis o ...
DOI:: 10.1016/j.jep.2020.113071
: https://doi.org/10.1016/j.jep.2020.113071

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1. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

2. Anti-cancer, anti-bacterial and anti-oxidant properties of an active fraction isolated from Curcuma zedoaria rhizomes

3. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

4. Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma

5. Anticancer activity of Alpinia purpurata (Vieill) K. Schum. against MNU and testosterone induced prostate cancer in male Wistar albino rats

6. Anticancer activity of an Artemisia annua L. hydroalcoholic extract on canine osteosarcoma cell lines

7. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza)

8. Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

9. Brucea javanica oil emulsion significantly improved the effect of anti–programmed cell death protein-1 immunotherapy

10. Cancer Cell Inhibiting Sea Cucumber (Holothuria leucospilota) Protein as a Novel Anti-Cancer Drug

11. Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells

12. Combination of Compound Kushen Injection and cisplatin shows synergistic antitumor activity in p53-R273H/P309S mutant colorectal cancer cells through inducing apoptosis

13. Comprehensive analysis of antibacterial and anti-hepatoma activity of metabolites from jujube fruit

14. Deciphering key regulators of Inonotus hispidus petroleum ether extract involved in anti-tumor through whole transcriptome and proteome analysis in H22 tumor-bearing mice model

15. Effects of ginger extract and its major component 6‐gingerol on anti‐tumor property through mitochondrial biogenesis in CD8+ T cells

16. Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity

17. Evaluation of the antimicrobial function of Ginkgo biloba exocarp extract against clinical bacteria and its effect on Staphylococcus haemolyticus by disrupting biofilms

18. Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation

19. Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms

20. Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma

21. Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation

22. Identifying the anti-metastasis effect of Anhydroicaritin on breast cancer: Coupling network pharmacology with experimental validation

23. Induction of P-glycoprotein expression by dandelion in tumor and heart tissues: Impact on the anti-tumor activity and cardiotoxicity of doxorubicin

24. Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer

25. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

26. Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy

27. Plant polypeptides: A review on extraction, isolation, bioactivities and prospects

28. Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering‐based high‐performance liquid chromatography–quadrupole time‐of‐flight tandem mass spectrometry

29. Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review

30. Research progress of matrine's anticancer activity and its molecular mechanism

31. Sanguisorba officinalis L. suppresses 5-fluorouracil-sensitive and-resistant colorectal cancer growth and metastasis via inhibition of the Wnt/β-catenin pathway

32. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-κB signaling in hepatocellular carcinoma cells

33. Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum

34. The antitumour activity of C21 steroidal glycosides and their derivatives of Baishouwu: A review

35. A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma

36. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

37. Aloe vera gel extract: Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells

38. Anti-esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways

39. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway

40. Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression

41. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity

42. Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology

43. Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

44. Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis

45. Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

46. Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

47. Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation

48. RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells

49. Remodeling the homeostasis of pro- and anti-angiogenic factors by Shenmai injection to normalize tumor vasculature for enhanced cancer chemotherapy

50. Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells

51. Scutellariabarbata D. Don extraction selectively targets stemness-prone NSCLC cells by attenuating SOX2/SMO/GLI1 network loop

52. Taraxacum mongolicum extract inhibited malignant phenotype of triple-negative breast cancer cells in tumor-associated macrophages microenvironment through suppressing IL-10 / STAT3 / PD-L1 signaling pathways

53. Tissue distribution, metabolism and absorption of Rhizoma Paridis Saponins in the rats

54. Use Chou's 5-steps rule to study how Baicalin suppresses the malignant phenotypes and induces the apoptosis of colorectal cancer cells

55. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

56. An isolated compound from stems and leaves of Coix lacryma-jobi L. and its anticancer effect

57. A review of Cremastra appendiculata (D.Don) Makino as a traditional herbal medicine and its main components

58. The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

59. An updated review on pharmacological properties of neferine—A bisbenzylisoquinoline alkaloid from Nelumbo nucifera

60. Actinidia Chinensis Planch Root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting the DLX2/TARBP2/JNK/AKT pathway

61. Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation

62. Anti-cancer activity of Conyza blinii saponin against cervical carcinoma through MAPK/TGF-β/Nrf2 signaling pathways

63. Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: Status and prospect

64. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

65. Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling

66. Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives

67. Cancer cell membrane-camouflaged MOF nanoparticles for a potent dihydroartemisinin-based hepatocellular carcinoma therapy

68. Caspase 3-mediated cytotoxicity of mealworm larvae (Tenebrio molitor) oil extract against human hepatocellular carcinoma and colorectal adenocarcinoma

69. Cell death induction by Ranunculus ternatus extract is independent of mitochondria and dependent on Caspase-7

70. Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity