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1. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

2. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:
Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:
... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:
10.3390/plants11020194

3. Cytotoxic activity of crude extracts and fractions of African peach (nauclea latifolia smith) stem bark on two cancer cell lines

Author:
Oluwakemi Charles-Okhe; Michael A. Odeniyi; Titilayo O. Fakeye; Omonike O. Ogbole; Toluwanimi E. Akinleye; Adekunle J. Adeniji
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100212
ISSN:
2667-0313
Subject:
Cercopithecus aethiops; Sarcocephalus latifolius; antineoplastic activity; bark; bark extracts; breast neoplasms; cell lines; colorimetry; cytotoxicity; drug therapy; ethyl acetate; fractionation; hexane; kidneys; liquid chromatography; methanol; neoplasm cells; peaches; skeletal muscle; vincristine
Abstract:
... The purpose of this research work is to investigate and establish the anticancer (cytotoxic) properties of African peach (Nauclea latifolia) stem bark extract and fractions on breast cancer cell lines (MCF-7), skeletal muscle cancer (RD) cell lines and to determine the selectivity index (SI) on normal African green monkey kidney cell lines (Vero). Crude extract and fractions obtained from acid-bas ...
DOI:
10.1016/j.phyplu.2021.100212

4. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:
Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:
Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:
0163-4984
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:
... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:
10.1007/s12011-021-02812-0

5. Engineering Chemotherapeutic-Augmented Calcium Phosphate Nanoparticles for Treatment of Intraperitoneal Disseminated Ovarian Cancer

Author:
Miaojuan Qiu; Junzong Chen; Xiuyu Huang; Binbin Li; Shiqiang Zhang; Peng Liu; Qiang Wang; Zhi Rong Qian; Yihang Pan; Yu Chen; Jing Zhao
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 21954-21965
ISSN:
1944-8252
Subject:
antineoplastic activity; apoptosis; calcium; calcium phosphates; cell lines; doxorubicin; drug therapy; endoplasmic reticulum stress; humans; intraperitoneal injection; mitochondria; models; mortality; nanomedicine; ovarian neoplasms; toxicity
Abstract:
... Ovarian cancer is a common gynecologic malignancy with a high fatality rate. Intraperitoneal chemotherapy has been proved as an efficient clinical treatment for disseminated ovarian cancer. However, there are limitations for conventional small molecule drugs to achieve an ideal therapeutic effect. Herein, a synergistic treatment for intraperitoneally disseminated ovarian cancer was achieved by Arg ...
DOI:
10.1021/acsami.2c02552

6. Gas chromatographic-mass spectrometric analysis, antioxidant, antiproliferative and antibacterial activities of the essential oil of Prangospabularia

Author:
Javid A. Banday; Zubaid-ul-khazir Rather; Gulam N. Yatoo; Mohammad Asif Hajam; Sajad A. Bhat; Vichangal Pridiuldi Santhanakrishnan; Alia Farozi; Manzoor A. Rather; Shahid Rasool
Source:
Microbial pathogenesis 2022 v.166 pp. 105540
ISSN:
0882-4010
Subject:
Escherichia coli; Micrococcus; Prangos pabularia; acetates; acetone; adenocarcinoma; agar; aldehydes; antibacterial properties; antineoplastic activity; breasts; cell lines; cytotoxicity; epithelium; essential oils; free radicals; humans; lungs; oils; pathogenesis; streptomycin; sulfates; toxicity testing; uterine cervical neoplasms; India
Abstract:
... The essential oil composition of the shoot parts of Prangos pabularia, growing in Drass area of Ladakh, India, along with its antioxidant, antibacterial and anticancer activity, is reported for the first time. Gas chromatography coupled with mass spectrometry (GC-MS) revealed the presence of 31 constituents, representing 97.342% of the total essential oil. The major constituents of essential oil w ...
DOI:
10.1016/j.micpath.2022.105540

7. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

Author:
Sahil Kapoor; Hemant Sood; Shweta Saxena; Om Prakash Chaurasia
Source:
Bioprocess and biosystems engineering 2022 v.45 no.2 pp. 365-380
ISSN:
1615-7591
Subject:
Hordeum vulgare; Rhodiola; Withania somnifera; agricultural industry; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bioprocessing; carotenoids; cell lines; cell viability; chlorophyll; cytotoxicity; dose response; germination; nanosilver; neoplasm cells; p-nitrophenol; photosynthesis; pollutants; pollution; remediation; root extracts; silver nitrate; sustainable technology; zeta potential
Abstract:
... This study presents the development of a sustainable production process of environmentally benign silver nanoparticles (AgNPs) from aqueous root extract of Rhodiola imbricata (RI) and Withania somnifera (WS) for mitigating environmental pollution and investigating their potential applications in agriculture and biomedical industry. RIWS-AgNPs were characterized using several analytical techniques ...
DOI:
10.1007/s00449-021-02666-9

8. Lead Borate Nanoparticles Induce Apoptotic Gene Activity in P53 Mutant Cancer Cells

Author:
Taha Bartu Hayal; Oğuz Kaan Kırbaş; Batuhan Turhan Bozkurt; Pakize Neslihan Taşlı; Berna Bülbül; Seda Beyaz; Fikrettin Şahin
Source:
Biological trace element research 2022 v.200 no.2 pp. 574-581
ISSN:
0163-4984
Subject:
antineoplastic activity; apoptosis; borates; breast neoplasms; cell lines; cell viability; lead; lead nitrate; mutants; mutation; neoplasm cells; quantitative polymerase chain reaction; research; therapeutics; toxicity; trace elements; tumor suppressor protein p53
Abstract:
... Cancer is a complex and multistage disease that causes suffering worldwide. Several mutations in tumor suppressor proteins are mostly responsible for tumorigenic development. Thus, determination of the mutations and developing a mutation targeted therapy are crucial in order to cure cancer. Moreover, since healthy cells do not have mutations in their tumor suppressor genes, mutation-specific treat ...
DOI:
10.1007/s12011-021-02696-0

9. The exploitation of rice husk biomass for the bio-inspired synthesis of gold nanoparticles as a multifunctional material for various biological and photocatalytic applications

Author:
Asmaa G. Harby; Ola M. El-Borady; Maged El-Kemary
Source:
Bioprocess and biosystems engineering 2022 v.45 no.1 pp. 61-74
ISSN:
1615-7591
Subject:
Candida albicans; Staphylococcus aureus; absorption; adenocarcinoma; antineoplastic activity; antioxidant activity; biomass; bioprocessing; biosynthesis; cell lines; methylene blue; nanogold; neoplasm cells; p-nitrophenol; pH; photocatalysis; phytochemicals; plant extracts; rice; rice hulls; spectral analysis; surface plasmon resonance; temperature; thermal stability
Abstract:
... We report an efficient and facile approach to biosynthesis of gold nanoparticles (AuNPs) using the extract of an agro-waste rice husk generated from rice production. The biosynthesized NPs produced were characterized by UV–Visible absorption, TEM, XRD, EDX, and FTIR methods. The impact of temperature and pH on the stability of the synthesized AuNPs was also studied. The TEM imaging revealed the fo ...
DOI:
10.1007/s00449-021-02639-y

10. Ultrasound assisted a one pot multicomponent and greener synthesis of 1,2,3-triazole incorporated aurone hybrids: Cathepsin B inhibition, anti-cancer activity against AGS cell line, and in-silico docking evaluation

Author:
Bhavna Saroha; Gourav Kumar; Suresh Kumar; Meena Kumari; Manishita Rani; Neera Raghav; Pranab Kumar Sahoo; Sushmita Ghosh; Sutapa Mahata; Vilas D. Nasare
Source:
Current research in green and sustainable chemistry 2022 v.5 pp. 100295
ISSN:
2666-0865
Subject:
antineoplastic activity; apoptosis; aspirin; aurones; biomarkers; cathepsin B; cell lines; chemistry; computer simulation; curcumin; cysteine; cytotoxicity; green chemistry; hybrids; in vitro studies; neoplasm progression; research; risk factors; ultrasonic treatment; ultrasonics
Abstract:
... Cathepsin B represents a group of lysosomal-encapsulated cellular cysteine proteases, whose upregulation is the critical risk factor for cancer progression and in the regulation of degenerative processes like apoptosis. Therefore, cysteine cathepsins are used as effective biomarkers for cancers and other neurodegenerative disorders and have become specific targets in drug designing. To diversify t ...
DOI:
10.1016/j.crgsc.2022.100295

11. A tumorigenic cell line derived from a hamster cholangiocarcinoma associated with Opisthorchis felineus liver fluke infection

Author:
Viatcheslav A. Mordvinov; Galina A. Minkova; Anna V. Kovner; Dmitriy V. Ponomarev; Maria N. Lvova; Oxana Zaparina; Svetlana A. Romanenko; Alexander G. Shilov; Maria Y. Pakharukova
Source:
Life sciences 2021 v.277 pp. 119494
ISSN:
0024-3205
Subject:
Opisthorchis; antineoplastic activity; bile; biomarkers; cell culture; cell lines; epithelium; hamsters; humans; immunocytochemistry; immunohistochemistry; karyotyping; liver; liver flukes; models; neoplasm cells; neoplasms; opisthorchiasis; resveratrol; risk factors; vimentin
Abstract:
... The food-born trematode Opisthorchis felineus colonizes bile ducts of the liver of fish-eating mammals including humans. There is growing evidence that this liver fluke is a risk factor for cholangiocarcinoma (CCA). Cancer cell lines are necessary for drug screening and for identifying protein markers of CCA. The aim was to establish a cell line derived from cholangiocarcinoma associated with opis ...
DOI:
10.1016/j.lfs.2021.119494

12. An α-D-galactan and a β-D-glucan from the mushroom Amanita muscaria: Structural characterization and antitumor activity against melanoma

Author:
Matheus Zavadinack; Daniel de Lima Bellan; Jessica Loren da Rocha Bertage; Shayane da Silva Milhorini; Edvaldo da Silva Trindade; Fernanda Fogagnoli Simas; Guilherme Lanzi Sassaki; Lucimara M.C. Cordeiro; Marcello Iacomini
Source:
Carbohydrate polymers 2021 v.274 pp. 118647
ISSN:
0144-8617
Subject:
Amanita muscaria; antineoplastic activity; cell adhesion; cell lines; cell proliferation; fibroblasts; melanoma; mushrooms; ultrafiltration; water solubility
Abstract:
... Polysaccharides α-D-galactan (GAL-Am) and β-D-glucan (GLC-Am) were obtained from Amanita muscaria fruiting bodies. They were purified using different methodologies, such as Fehling precipitation (for both fractions), freeze-thawing process and ultrafiltration (for GLC-Am). Results showed that the GAL-Am has (1 → 6)-linked Galp main chain branched at O-2 by terminal Galp units and has not been prev ...
DOI:
10.1016/j.carbpol.2021.118647

13. Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts

Author:
Kartik Chandra Guchhait; Tuhin Manna; Manas Barai; Monalisha Karmakar; Sourav Kumar Nandi; Debarati Jana; Aditi Dey; Suman Panda; Priyanka Raul; Anuttam Patra; Rittwika Bhattacharya; Subhrangsu Chatterjee; Amiya Kumar Panda; Chandradipa Ghosh
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 42
ISSN:
2662-7671
Subject:
Azadirachta indica; Staphylococcus aureus; Vibrio cholerae; acridine orange; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; bacterial culture; biofilm; breast neoplasms; cell lines; cytotoxicity; ethidium; fluorescence microscopy; gas chromatography; humans; mass spectrometry; methanol; minimum inhibitory concentration; multiple drug resistance; neoplasm cells; phthalic acid; toxicity testing; triazines
Abstract:
... BACKGROUND: Antibiotic resistances of pathogens and breast cancer warrant the search for new alternative strategies. Phytoextracts can eradicate microbe-borne diseases as well as cancer with lower side effects compared to conventional antibiotics. AIM: Unripe and ripe Azadirachta indica (neem) seed extracts were explored as potential antibiofilm and anticancer agents in combating multidrug-resista ...
DOI:
10.1186/s12906-022-03513-4

14. Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment

Author:
Arghavan Fatahi; Neda Soleimani; Parviz Afrough
Source:
International Journal of Food Sciences 2021 v.2021 pp. -
ISSN:
2314-5765
Subject:
antineoplastic activity; brain; cell lines; cell viability; cytotoxicity; death; dose response; fermentation; glioblastoma; kefir; milk; neoplasm cells; probiotics; therapeutics
Abstract:
... Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumo ...
DOI:
10.1155/2021/8180742

15. Anticancer potential of limonoids from Swietenia macrophylla: Genotoxic, antiproliferative and proapoptotic effects towards human colorectal cancer

Author:
Laine C. Pinto; Felipe P. Mesquita; Leilane H. Barreto; Pedro F.N. Souza; Ingryd N.F. Ramos; Adrielly V.U. Pinto; Bruno M. Soares; Milton N. da Silva; Rommel M.R. Burbano; Raquel C. Montenegro
Source:
Life sciences 2021 v.285 pp. 119949
ISSN:
0024-3205
Subject:
DNA damage; Swietenia macrophylla; animal models; antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cell membranes; colorectal neoplasms; cytotoxicity; erythrocytes; humans; limonoids; mutagens; neoplasm cells
Abstract:
... Swietenia macrophylla have been considered for the treatment of various diseases, including anticancer activity. This study aimed to investigate the anticancer activity of S. macrophylla leaves extract and its isolated compound towards human colorectal cancer cell line.Hexanic extract of S. macrophylla leaves demonstrated relevant cytotoxicity only against colon cancer cell line HCT116.Our results ...
DOI:
10.1016/j.lfs.2021.119949

16. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:
Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:
2662-7671
Subject:
Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:
... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:
10.1186/s12906-022-03526-z

17. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

Author:
Kinjal P. Bhadresha; Nayan K. Jain; Rakesh M. Rawal
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1023-1036
ISSN:
1532-7914
Subject:
Moringa oleifera; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioactive compounds; bioavailability; cell lines; cell viability; cytotoxicity; digestion; flavonoids; gene expression; glutathione; interphase; metastasis; polyphenols; prostatic neoplasms; protective effect; spectral analysis
Abstract:
... Moringa oleifera possesses numerous advantageous effects like anti-microbial, antioxidant, and anti-inflammatory, leaves contain a high multiplicity of the bioactive compound; however, little is identified about its bioaccessibility. The objective of this study was to assess the bioefficacy, bioaccessible and anticancer activity of Moringa oleifera in a PC3 cell line before and after simulated in ...
DOI:
10.1080/01635581.2021.1933099

18. Biogenic and biocompatible silver nanoparticles for an apoptotic anti-ovarian activity and as polydopamine-functionalized antibiotic carrier for an augmented antibiofilm activity

Author:
Mohamed G. Aboelmaati; Sara A. Abdel Gaber; Wafaa E. Soliman; Walid F. Elkhatib; Amr M. Abdelhameed; Heba A. Sahyon; Maged El-Kemary
Source:
Colloids and surfaces 2021 v.206 pp. 111935
ISSN:
0927-7765
Subject:
Acinetobacter baumannii; COVID-19 infection; Hibiscus sabdariffa; Klebsiella pneumoniae; Pseudomonas aeruginosa; antibiotics; antimicrobial properties; antineoplastic activity; apoptosis; biofilm; cell lines; inhibitory concentration 50; lethal dose 50; mice; moxifloxacin; nanosilver; synergism; synthesis
Abstract:
... Silver nanoparticles (AgNPs) could be employed in the combat against COVID-19, yet are associated with toxicities. In this study, biogenic and biocompatible AgNPs using the agro-waste, non-edible Hibiscus sabdariffa stem were synthesized. Under optimized reaction conditions, synthesized green AgNPs were crystalline, face cubic centered, spherical with a diameter of around 17 nm and a surface charg ...
DOI:
10.1016/j.colsurfb.2021.111935

19. Biological Activity of the Extracts from Pecan Shelling Industry Byproducts

Author:
Canan Sevimli-Gur; Yuksel Gezgin; Ahmet Oz; Shaymaa Al Sharqi; Zinar Pinar Gumus; Nurhan Turgut Dunford
Source:
Transactions of the ASABE v.64 no.3 pp. 869-877
ISSN:
2151-0032
Subject:
Escherichia coli; antimicrobial properties; antineoplastic activity; antioxidants; cell lines; cultivars; ethanol; industry; inhibitory concentration 50; lipid content; liquid chromatography; mass spectrometry; meat; neoplasm cells; pecan shells; pecans; phytochemicals; streams
Abstract:
... HighlightsThe first study on characterization of the extracts obtained from industrial pecan nut processing byproducts.Chemical composition and biological activity of the extracts varied with type of byproduct and the pecan cultivars used in the process.Pecan shell extracts exhibited anticancer, antioxidant, and antimicrobial activity.Abstract. Industrial processing of pecan nuts produces large am ...
DOI:
10.13031/trans.14439

20. Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line

Author:
Edgar Tavares-da-Silva; Eurico Pereira; Ana S. Pires; Ana R. Neves; Catarina Braz-Guilherme; Inês A. Marques; Ana M. Abrantes; Ana C. Gonçalves; Francisco Caramelo; Rafael Silva-Teixeira; Fernando Mendes; Arnaldo Figueiredo; Maria Filomena Botelho
Source:
Biology 2021 v.10 no.1 pp. -
ISSN:
2079-7737
Subject:
antineoplastic activity; assays; biochemical pathways; cancer therapy; cell cycle checkpoints; cell lines; cell proliferation; cell viability; exposure duration; flow cytometry; fluorescence; glutathione; interphase; membrane potential; mitochondrial membrane; neoplasm cells; nitric oxide; nitrogen; nonthermal processing; oxygen; protein content; toxicity testing; urinary bladder neoplasms
Abstract:
... Antitumor therapies based on Cold Atmospheric Plasma (CAP) are an emerging medical field. In this work, we evaluated CAP effects on bladder cancer. Two bladder cancer cell lines were used, HT-1376 (stage III) and TCCSUP (stage IV). Cell proliferation assays were performed evaluating metabolic activity (MTT assay) and protein content (SRB assay). Cell viability, cell cycle, and mitochondrial membra ...
DOI:
10.3390/biology10010041

21. Complexation-induced nanoarchitectonics of sulfonate cailx[4]resorcinol substituted at the upper rim by N-methyl-d-glucamine fragments: Morphological transition and in vitro anticancer activity

Author:
Nadezda E. Kashapova; Ruslan R. Kashapov; Albina Y. Ziganshina; Syumbelya K. Amerhanova; Anna P. Lyubina; Alexandra D. Voloshina; Vadim V. Salnikov; Lucia Y. Zakharova
Source:
Colloids and surfaces 2022 v.643 pp. 128796
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; copper; cytotoxicity; ligands; liver; neoplasms; resorcinol; sulfonates
Abstract:
... Complexes of various nitrogen-containing ligands with transition metals are known for their anticancer activity. At the same time, the shape of aggregates of these complexes can have a significant effect on cytotoxicity and selectivity of action in tumor cells, however, this issue has received insufficient attention in the literature. In this work, the selective binding ability of sulfonate calix[ ...
DOI:
10.1016/j.colsurfa.2022.128796

22. Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells

Author:
Tulin Ozkan; Yalda Hekmatshoar; Hanife Pamuk; Merve Ozcan; Guler Yaman; Gulsah Ceylan Yagiz; Cigdem Akdemir; Asuman Sunguroglu
Source:
Molecular biology reports 2021 v.48 no.2 pp. 1625-1631
ISSN:
0301-4851
Subject:
antineoplastic activity; apoptosis; cell lines; cell viability; cytotoxicity; drugs; flow cytometry; gene expression; genes; ginger; molecular biology; myeloid leukemia; therapeutics; toxicity testing; tyrosine
Abstract:
... Chronic Myeloid Leukemia (CML) is a clonal hematopoietic malignancy characterized by the formation of BCR-ABL fusion protein. Imatinib (IMA) is a BCR-ABL tyrosine kinase inhibitor (TKI), which exhibited a high rate of response for newly diagnosed CML patients. Emergence of IMA resistance considered as a major challenge in CML therapy. Recent studies reported the anti-cancer effect of natural extra ...
DOI:
10.1007/s11033-021-06141-2

23. Density functional theoretical study, spectroscopic characterization and molecular docking of the diuretic drug, spironolactone, adsorbed on AuNPs surface and in-vitro studies based on anticancer activity studies against A549 lung cancer cell line

Author:
V. Shyni; D.R. Leenaraj; Reena Ittyachan; Rejeena V. Rajan; G.J. Shyju; Lynnette Joseph; D. Sajan
Source:
Colloids and surfaces 2022 v.646 pp. 128255
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; density functional theory; drugs; electron transfer; energy; gold; hydrogen; lung neoplasms; neoplasm cells; spectral analysis; spironolactone; therapeutics; toxicity testing; transmission electron microscopes
Abstract:
... In this study, the geometry, intramolecular charge transfer interactions, and harmonic vibrational frequencies of the diuretic drug, Spironolactone (SPL) and SPL adsorbed on gold nanoparticle (SPLA molecule) were investigated with the help of density functional theory method. Both molecules were found to be stabilized by intramolecular hydrogen bonds C₇-H₃₇. O₂₇ and C₁₆-H₄₇. O₂, as well as intramo ...
DOI:
10.1016/j.colsurfa.2022.128255

24. Diadema setosum: isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer

Author:
Fahd M. Abdelkarem; Ezz-Eldin K. Desoky; Alaa M. Nafady; Ahmed E. Allam; Aldoushy Mahdy; Ahmed Ashour; Kuniyoshi Shimizu
Source:
Natural product research 2022 v.36 no.4 pp. 1118-1122
ISSN:
1478-6427
Subject:
antineoplastic activity; cell lines; chromatography; colorimetry; cytotoxicity; ethyl acetate; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; research; secondary metabolites; uterine cervical neoplasms
Abstract:
... In our promising project toward discovery of secondary metabolites with potential anticancer activity against human cervical cancer, seven marine organisms were screened for their cytotoxic activity against HeLa cancer cell line using MTT colorimetric assay. The crude extract of the outer shell of Diadema setosum showed promising activity with 88.02% inhibition at a concentration 250 µg/ml. Chroma ...
DOI:
10.1080/14786419.2020.1855162

25. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa

Author:
Fang-Yuan Zhang; Run-Ze Li; Cong Xu; Xing-Xing Fan; Jia-Xin Li; Wei-Yu Meng; Xuan-Run Wang; Tu-Liang Liang; Xiao-Xiang Guan; Hu-Dan Pan; Liang Liu; Xiao-Jun Yao; Qi Biao Wu; Elaine Lai-Han Leung
Source:
Phytomedicine 2022 v.95 pp. 153786
ISSN:
0944-7113
Subject:
Rheum officinale; Western blotting; antineoplastic activity; apoptosis; cell cycle; cell lines; cytotoxicity; emodin; enzyme inhibition; flow cytometry; lung neoplasms; lungs; mutants; phospholipases; reactive oxygen species; therapeutics
Abstract:
... Lung cancer has become the principal cause of cancer-related deaths. Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics. Secretory phospholipase A2-IIa (sPLA2-IIa) is overexpressed in cancers and plays an important role in cancer development.This study aims to investigate the anti-tumor mechanism of emodin i ...
DOI:
10.1016/j.phymed.2021.153786

26. Ethyl acetate extract of Elephantopus mollis Kunth induces apoptosis in human gastric cancer cells

Author:
Tran Dang Thanh Tam; Truong Thi Bich Ngoc; Nguyen Thi Hoai Nga; Nguyen Thi My Trinh; Tran Linh Thuoc; Dang Thi Phuong Thao
Source:
BMC complementary medicine and therapies 2021 v.21 no.1 pp. 273
ISSN:
2662-7671
Subject:
Elephantopus; alternative medicine; antineoplastic activity; apoptosis; caspase-3; cell lines; cytotoxicity; death; ethyl acetate; fibroblasts; gene expression; humans; mitochondria; neoplasm cells; shrinkage; stomach neoplasms
Abstract:
... BACKGROUND: Gastric cancer is one of the most leading causes of cancer death worldwide. Therefore, treatment studies have been being conducted, one of which is screening of novel agents from medicinal herbs. Elephantopus mollis Kunth (EM) belonging to Asteraceae family is a perennial herb with several therapeutic properties including anticancer activity. However, the effect of this species on gast ...
DOI:
10.1186/s12906-021-03444-6

27. Evaluation of anti-proliferative activity of Eryngium caucasicum on melanoma cancer cells

Author:
Haleh Forouhandeh; Zahra Rezaei Param; Ommoleila Molavi; Parina Asgharian; Vahideh Tarhriz
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 134
ISSN:
2662-7671
Subject:
Eryngium caeruleum; alternative medicine; analgesics; antineoplastic activity; antioxidants; apoptosis; cell lines; cytotoxicity; fractionation; hexane; melanoma; methanol; methylene chloride; necrosis; neoplasm cells
Abstract:
... BACKGROUND: The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. Previous research on the anti-cancer activity of Eryngium in some cancer cell lines has led us to explore the anti-proliferative activity of E. caucasicum in the B16F10 cell line. OBJECTIVE ...
DOI:
10.1186/s12906-022-03618-w

28. Evaluation of anti-tumor effect of the exopolysaccharide from new cold-adapted yeast, Rhodotorula mucilaginosa sp. GUMS16 on chronic myeloid leukemia K562 cell line

Author:
Setare Kheyrandish; Amirhossein Rastgar; Masoud Hamidi; Seyed Mehdi Sajjadi; Gholamreza Anani Sarab
Source:
International journal of biological macromolecules 2022 v.206 pp. 21-28
ISSN:
0141-8130
Subject:
Rhodotorula rubra; antineoplastic activity; antioxidants; apoptosis; biopolymers; cell cycle; cell lines; cytotoxicity; exopolysaccharides; gene expression; inhibitory concentration 50; lactic acid; myeloid leukemia; neoplasm cells; quantitative polymerase chain reaction; viability; yeasts
Abstract:
... Recently, the development and application of fungal exopolysaccharides (EPS) as natural biopolymers are on the rise. The present study is based on the investigation of possible antiproliferative and antioxidant activities of EPS from the Rhodotorula mucilaginosa sp. GUMS16 on BCR-ABL positive cells (K562). The cytotoxicity, colony formation assays lactate and dehydrogenase (LDH) activity were perf ...
DOI:
10.1016/j.ijbiomac.2022.02.113

29. FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway

Author:
Xiang Jing; Shuai Niu; Yi Liang; Huiping Chen; Ning Wang; Youmei Peng; Fang Ma; Wanying Yue; Qingduan Wang; Junbiao Chang; Yi Zhang; Yan Zhang
Source:
Genes & genomics 2022 v.44 no.1 pp. 123-131
ISSN:
1976-9571
Subject:
Western blotting; antineoplastic activity; apoptosis; cadherins; cell adhesion; cell lines; cell movement; cell viability; cytosine; dose response; flow cytometry; genomics; immunohistochemistry; lung neoplasms; metastasis; mice; mitochondria; nucleosides; protein synthesis; toxicity; xenotransplantation
Abstract:
... BACKGROUND: Previously, we published that 4′-azid-2′-deoxy-2′-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. OBJECTIVE: This study aimed to further explore the role and molecular mechanism of FNC in non-small cell lung cancer (NSCLC). METHODS: FNC was tested in the NSCLC H460 cell line, the Lewis mouse model, and the H460 cell xenograft mod ...
DOI:
10.1007/s13258-021-01179-9

30. Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

Author:
Jia Xiong Ming; Zhao Cong Wang; Yi Huang; Hifumi Ohishi; Rong Ji Wu; Yan Shao; Hui Wang; Ming Yang Qin; Ze Liang Wu; Yi Yong Li; Shun Chang Zhou; Hui Chen; Hui Liu; Rong Xu
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113302
ISSN:
0378-8741
Subject:
Oriental traditional medicine; RNA interference; Saccharina japonica; Western blotting; antineoplastic activity; cadherins; cell lines; cell proliferation; cell viability; drugs; fibronectins; fluorescent antibody technique; gene expression; human diseases; immunohistochemistry; lung neoplasms; lungs; metastasis; models; neoplasm cells; phenotype; phosphatidylinositol 3-kinase; staining; tissue repair; transcription factor NF-kappa B; xenotransplantation
Abstract:
... Laminaria japonica, a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including lung cancer.To demonstrate the effects of Fucoxanthin (FX), a major active component extracted from Laminaria japonica on metastasis and Gefitinib (Gef) sensitivity in human lung cancer cells both in vitro and in vivo.Invasion and migration of lung cancer cells were det ...
DOI:
10.1016/j.jep.2020.113302

31. Gas Chromatographic-Mass Spectrometric Analysis, Antibacterial, Antioxidant and Antiproliferative Activities of the Needle Essential Oil of Abies pindrow growing wild in Kashmir, India

Author:
Zubaid-ul-khazir; Gulam N. Yatoo; Humara Wani; Shakeel A. Shah; Mohammad I. Zargar; Manzoor A. Rather; Javid A. Banday
Source:
Microbial pathogenesis 2021 v.158 no. pp. 105013
ISSN:
0882-4010
Subject:
Abies pindrow; Bacillus subtilis; Pseudomonas aeruginosa; agar; antibacterial properties; antineoplastic activity; breast neoplasms; breasts; cell lines; cytotoxicity; epithelial cells; epithelium; essential oils; free radicals; humans; limonene; lungs; minimum inhibitory concentration; neuroglia; oils; pathogenesis; rats; sesquiterpenoids; streptomycin; sulfates; toxicity testing; India
Abstract:
... The essential oil composition of the leaves of Abies pindrow, growing in Kashmir, India, along with its antioxidant, antibacterial and anticancer activity is reported for the first time. Gas chromatography coupled with mass spectrometry (GC-MS) revealed the presence of 12 constituents, representing 99.9% of the total oil. The major constituents of the oil were limonene (38.9%), α-pinene (36.5%), β ...
DOI:
10.1016/j.micpath.2021.105013

32. Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer

Author:
Ahmed S. Doghish; Gharieb S. El-Sayyad; Al-Aliaa M. Sallam; Waleed F. Khalil; Waleed M. A. El Rouby
Source:
RSC advances 2021 v.11 no.46 pp. 29052-29064
ISSN:
2046-2069
Subject:
EDTA (chelating agent); antineoplastic activity; apoptosis; breast neoplasms; caspase-8; caspase-9; cell lines; chitosan; cytotoxicity; flow cytometry; graphene oxide; humans; nanocomposites; neoplasm cells; vascular endothelial growth factor receptor-2
Abstract:
... To achieve the advanced anticancer activity of nanocomposites fabricated with graphene oxide (GO), a novel procedure was used during the fabrication of chitosan (CS) or ethylene diamine tetra acetic acid (EDTA). The synthesized GO-based nanocomposites were distinguished through different analytical techniques. The cytotoxic activity was examined using MTT assays against three different cancer cell ...
DOI:
10.1039/d1ra04345e

33. Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123

Author:
Michael A. Morgan; Arnold Kloos; Daniela Lenz; Nadine Kattre; Juliette Nowak; Marco Bentele; Maximilian Keisker; Julia Dahlke; Katharina Zimmermann; Martin Sauer; Michael Heuser; Axel Schambach
Source:
Viruses 2021 v.13 no.7 pp. -
ISSN:
1999-4915
Subject:
antigens; antineoplastic activity; cell lines; cytotoxicity; gene expression; gene transfer; humans; interleukin-15; interleukin-3; models; myeloid leukemia; natural killer cells; retroviral vectors; transgenes; xenotransplantation
Abstract:
... Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression. Here, we used alpharetroviral vectors to modify NK-92 cells, a natural killer cell line, with a third-generation CAR designed to target the IL-3 receptor subu ...
DOI:
10.3390/v13071365

34. In vitro anticancer activity of curcumin loaded chitosan nanoparticles (CLCNPs) against vero cells

Author:
Deepika; Minakshi Prasad; Raj Kumar Salar
Source:
Pharmacological research 2022 pp. 100116
ISSN:
2667-1425
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; antineoplastic agents; cell lines; chitosan; curcumin; differential thermal analysis; electron microscopy; gelation; pollution; research; temperature; thermogravimetry; ultraviolet-visible spectroscopy
Abstract:
... The global burden of cancer is rising due to increasing pollution, change in life styles and dietary habits rendering it as one of the leading cause of deaths worldwide. Poor availability of anticancer drugs in affected tissues necessitates higher doses and longer treatment regimens to treat most cancers. In the present investigation curcumin, an anticancer drug was loaded in chitosan nanoparticle ...
DOI:
10.1016/j.prmcm.2022.100116

35. In vitro anticancer activity of extracted oil from Parrotiopsis jacquemontiana (Decne) Rehder

Author:
Saima Ali; Muhammad Rashid Khan; Asghar Khan; Raees Khan
Source:
Phytomedicine 2021 v.91 pp. 153697
ISSN:
0944-7113
Subject:
antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; cell lines; cell proliferation; cytotoxicity; dose response; inhibitory concentration 50; liver; oils
Abstract:
... Parrotiopsis jacquemontiana, commonly referred to as “Beranj” in the local community, is widely used traditionally and has numerous health benefits. However, no studies have been conducted to investigate its anticancer potential, particularly its extracted oil.The present study was put forth to appraise the anticancer potential of Parrotiopsis jacquemontiana extracted oil against liver (hcclm3 and ...
DOI:
10.1016/j.phymed.2021.153697

36. Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer

Author:
Marym Mohammad Hadi; Heather Nesbitt; Hamzah Masood; Fabiola Sciscione; Shiv Patel; Bala S. Ramesh; Mark Emberton; John F. Callan; Alexander MacRobert; Anthony P. McHale; Nikolitsa Nomikou
Source:
Journal of controlled release 2021 v.329 pp. 76-86
ISSN:
0168-3659
Subject:
adverse effects; antineoplastic activity; body weight; cathepsin B; cell lines; composite polymers; cytotoxicity; humans; in vivo studies; mice; nanoparticles; neoplasm cells; oxygen production; pH; particle size; prostatic neoplasms; severe combined immunodeficiency; singlet oxygen; ultrasonics; xenotransplantation
Abstract:
... Nano-formulations that are responsive to tumour-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel stimulus-responsive nanoparticulate platform for the targeted treatment of prostate cancer using sonodynamic therapy (SDT). The nanoparticles were pre ...
DOI:
10.1016/j.jconrel.2020.11.040

37. Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

Author:
J. Dharani; S. Ravi
Source:
Chemistry of natural compounds 2022 v.58 no.1 pp. 40-46
ISSN:
0009-3130
Subject:
Cyanthillium cinereum; DNA replication; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; interphase; sesquiterpenoid lactones
Abstract:
... Three sesquiterpene lactones has been isolated from Cyanthillium cinereum (L.) H. Rob. by bioactivity guided assay and characterized by spectral methods as compounds 1, 2, and 3. The in vitro anticancer activity was tested against 786-O, MCF-7, and K562 cells by the MTT assay. Compound 1 showed IC₅₀ values of 12.5 and 10.4 μg/mL against 786-O cell line after 48 and 72 h, respectively, and matches ...
DOI:
10.1007/s10600-022-03593-1

38. LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

Author:
Kouadio Ibrahime Sinan; Uğur Akpulat; Afaf A. Aldahish; Yasemin Celik Altunoglu; Mehmet Cengiz Baloğlu; Dimitrina Zheleva-Dimitrova; Reneta Gevrenova; Devina Lobine; Mohamad Fawzi Mahomoodally; Ouattara Katinan Etienne; Gokhan Zengin; Shafi Mahmud; Raffaele Capasso
Source:
Antioxidants 2021 v.10 no.12 pp. -
ISSN:
2076-3921
Subject:
Boerhavia diffusa; amylases; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; cell lines; chemical composition; ethyl acetate; flavonoids; glycosides; metabolites; methanol; methylene chloride; neoplasm cells; raw materials; tropical plants
Abstract:
... Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and biological capabilities of B. diffusa. An UHPLC-HRMS method was used to determine the chemical characterization. The biological ability was examined fo ...
DOI:
10.3390/antiox10122003

39. Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer

Author:
Xiaochun Zheng; Xiuli Yang; Jingyang Lin; Feifeng Song; Yanfei Shao
Source:
Phytomedicine 2021 v.85 pp. 153547
ISSN:
0944-7113
Subject:
Western blotting; antineoplastic activity; apoptosis; cell lines; colorectal neoplasms; curcumin; drug therapy; fluorouracil; gene targeting; radiotherapy; surgery; synergism; toxicity
Abstract:
... Colon cancer treatments include surgery, radiotherapy, and chemotherapy. Chemotherapy using 5-fluorouracil (5-FU) has been widely applied to treat colorectal cancer (CRC). However, it is important to explore the use of chemotherapy drugs in combination with other agents to decrease severe adverse effects.This study aimed to investigate the effects of curcumin in combination with 5-FU on the prolif ...
DOI:
10.1016/j.phymed.2021.153547

40. Mangiferin induces immune responses and evaluates the survival rate in WEHI‐3 cell generated mouse leukemia in vivo

Author:
Hung‐Sheng Shang; Chiung‐Ju Chen; Yung‐Luen Shih; Shu‐Fen Peng; Yung‐Liang Chen; Kuo‐Ching Liu; Hsieh‐Chou Huang; Shu‐Ching Hsueh; Kuo‐Wei Chen; Hsu‐Feng Lu; Mei‐Hui Lee; Ming‐Zhe Lee; Kung‐Wen Lu
Source:
Environmental toxicology 2021 v.36 no.1 pp. 77-85
ISSN:
1520-4081
Subject:
B-lymphocytes; T-lymphocytes; antineoplastic activity; body weight; cell lines; cell proliferation; concanavalin A; diet; ecotoxicology; flow cytometry; humans; immune response; information; intraperitoneal injection; leukemia; lipopolysaccharides; liver; macrophages; mice; monocytes; neoplasm cells; phagocytosis; polyphenols; population; spleen; splenocytes; survival rate
Abstract:
... Mangiferin is a naturally occurring polyphenol, widely distributed in Thymeraceae families, and presents pharmacological activity, including anti‐cancer activities in many human cancer cell lines. Mangiferin has also been reported to affect immune responses; however, no available information concerning the effects of mangiferin on immune reactions in leukemia mice in vivo. In the present study, we ...
DOI:
10.1002/tox.23013

41. Molecular characterization of canine SHP2 mutants and anti‐tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma

Author:
Hiroyuki Tani; Ryo Miyamoto; Tomokazu Nagashima; Masaki Michishita; Kyoichi Tamura; Makoto Bonkobara
Source:
Veterinary and comparative oncology 2022 v.20 no.1 pp. 109-117
ISSN:
1476-5810
Subject:
antineoplastic activity; cell lines; dogs; metastasis; mice; mutants; mutation; sarcoma; xenotransplantation
Abstract:
... Canine histiocytic sarcoma (HS) is an aggressive and highly metastatic neoplasm. Mutations in src homology 2 domain‐containing phosphatase 2 (SHP2; encoded by PTPN11), which recently have been identified in canine HS tumour cells, could be attractive therapeutic targets for SHP099, an allosteric inhibitor of SHP2. Here, molecular characteristics of wild‐type SHP2 and four SHP2 mutants (p.Ala72Gly, ...
DOI:
10.1111/vco.12751

42. Oxidative DNA cleavage mediated by a new unexpected [Pd(BAPP)][PdCl₄] complex (BAPP = 1,4-bis(3-aminopropyl)piperazine): crystal structure, DNA binding and cytotoxic behavior

Author:
Mona S. Ragab; Mohamed R. Shehata; Mohamed M. Shoukry; Matti Haukka; Mohamed A. Ragheb
Source:
RSC advances 2022 v.12 no.3 pp. 1871-1884
ISSN:
2046-2069
Subject:
DNA; DNA damage; Fourier transform infrared spectroscopy; X-ray diffraction; antibiotic resistance; antineoplastic activity; calves; cell lines; computer simulation; crystal structure; cytotoxicity; electrophoresis; humans; ligands; mass spectrometry; nuclear magnetic resonance spectroscopy; pharmacokinetics; piperazine; reducing agents; ultraviolet-visible spectroscopy
Abstract:
... A novel Pd(ii) double complex, [Pd(BAPP)][PdCl₄], containing the 1,4-bis(3-aminopropyl)piperazine (BAPP) ligand is investigated. X-ray crystallography of a single crystal confirmed the structure of the [Pd(BAPP)][PdCl₄] complex. The spectroscopic behavior was also elucidated using elemental analysis, nuclear magnetic resonance and Fourier-transform infrared spectroscopy, and mass spectrometry. The ...
DOI:
10.1039/d1ra07793g

43. PEG-polyaminoacid based micelles for controlled release of doxorubicin: Rational design, safety and efficacy study

Author:
Silvia Brunato; Francesca Mastrotto; Federica Bellato; Chiara Bastiancich; Alessandra Travanut; Mariangela Garofalo; Giuseppe Mantovani; Cameron Alexander; Veronique Preat; Stefano Salmaso; Paolo Caliceti
Source:
Journal of controlled release 2021 v.335 pp. 21-37
ISSN:
0168-3659
Subject:
anhydrides; antineoplastic activity; blood; cell lines; colorectal neoplasms; composite polymers; cytotoxicity; dose response; doxorubicin; glutamic acid; hydrazine; hydrazones; intravenous injection; leucine; mammary neoplasms (animal); mice; micelles; neoplasm cells; pH; polymerization; zeta potential
Abstract:
... A library of amphiphilic monomethoxypolyethylene glycol (mPEG) terminating polyaminoacid co-polymers able to self-assemble into colloidal systems was screened for the delivery and controlled release of doxorubicin (Doxo). mPEG-Glu/Leu random co-polymers were generated by Ring Opening Polymerization from 5 kDa mPEG-NH₂ macroinitiator using 16:0:1, 8:8:1, 6:10:1, 4:12:1 γ-benzyl glutamic acid carbox ...
DOI:
10.1016/j.jconrel.2021.05.010

44. Phenolic contents, chemical profiling, in silico and in vitro anti-inflammatory and anticancer properties of Alnus nitida (Spach) Endl

Author:
Umer Shaukat; Saeed Ahemad; Mei Wang; Shabana I. Khan; Zulfiqar Ali; Muhammad Imran Tousif; Hassan H. Abdallah; Ikhlas A. Khan; Muhammad Saleem; Mohamad Fawzi Mahomoodally
Source:
South African journal of botany 2021 v.138 pp. 148-155
ISSN:
0254-6299
Subject:
Alnus; anti-inflammatory activity; antineoplastic activity; cell lines; chemical constituents of plants; chloroform; computer simulation; cytotoxicity; extracts; industrial applications; ligands; macrophages; neoplasm cells; palmitic acid; phytopharmaceuticals; Pakistan
Abstract:
... Alnus nitida (Spach) Endl has been used as a remedy for inflammation-related disorders in the folk medicinal system by the inhabitants of the northern areas of Pakistan. This study deals with the phytochemical composition, cytotoxicity, and anti-inflammatory activity of various extracts of A. nitida. The phytochemical composition was established by measuring total phenolic contents through spectro ...
DOI:
10.1016/j.sajb.2020.12.010

45. Steroid Glycosides Hyrcanoside and Deglucohyrcanoside: On Isolation, Structural Identification, and Anticancer Activity

Author:
Silvie Rimpelová; Tomáš Zimmermann; Pavel B. Drašar; Bohumil Dolenský; Jiří Bejček; Eva Kmoníčková; Petra Cihlářová; Soňa Gurská; Lucie Kuklíková; Marián Hajdůch; Tomáš Ruml; Lubomír Opletal; Petr Džubák; Michal Jurášek
Source:
Foods 2021 v.10 no.1 pp. -
ISSN:
2304-8158
Subject:
antineoplastic activity; cell cycle checkpoints; cell lines; computer simulation; cytotoxicity; digitoxin; drugs; foods; models; neoplasm cells; ouabain; research; therapeutics
Abstract:
... Cardiac glycosides (CGs) represent a group of sundry compounds of natural origin. Most CGs are potent inhibitors of Na⁺/K⁺-ATPase, and some are routinely utilized in the treatment of various cardiac conditions. Biological activities of other lesser known CGs have not been fully explored yet. Interestingly, the anticancer potential of some CGs was revealed and thereby, some of these compounds are n ...
DOI:
10.3390/foods10010136

46. Study on the physicochemical properties and immunomodulatory anti-tumor effect of the Pholiota adiposa polysaccharide

Author:
Zhongwei Yang; Zijing Liu; Jie Xu; Junmo Zhu; Youwei Pu; Yixi Bao
Source:
Food & function 2022 v.13 no.9 pp. 5153-5165
ISSN:
2042-650X
Subject:
Pholiota adiposa; antineoplastic activity; apoptosis; arabinose; cell cycle; cell lines; coculture; cytotoxicity; fucose; galactose; galacturonic acid; glucose; glucuronic acid; hepatoma; immunomodulation; interleukin-12; interleukin-6; macrophages; mannose; molecular weight; polysaccharides; rhamnose; ribose; xylose
Abstract:
... In this study, the extraction, purification, physical and chemical properties, and biological activity of the Pholiota adiposa (PAP) polysaccharide were investigated. One fraction (PAP-1a) of Pholiota adiposa polysaccharides was isolated using DEAE Sepharose™ Fast Flow and Sephacryl™ S-300 High-Resolution columns. The HPLGPC results revealed that the molecular weight of PAP-1a was 16.453 kDa. PAP- ...
DOI:
10.1039/d1fo03628a

47. Synthesis of Nanocapsules Based on Biosynthesized Nickel Nanoparticles and Potato Starch: Antimicrobial, Antioxidant, and Anticancer Activity

Author:
Amr H. Hashem; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Mohamed Hasanin
Source:
Stärke = 2022 v.74 no.1-2 pp. e2100165
ISSN:
0038-9056
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Cryptococcus neoformans; Escherichia coli; Penicillium chrysogenum; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biopolymers; bioprocessing; biosynthesis; cell lines; inhibitory concentration 50; nanocapsules; nickel; potato starch; thermogravimetry
Abstract:
... Biogenic fabrication of nanoparticles (NPs) by fungi becomes a promising protocol due to effective and environmentally friendly bioprocess. The capsulation of nanoparticles into biopolymer has received considerable attention owing to improve stability. The nickel nanoparticles (Ni‐NPs) are synthesized using Penicillium chrysogenum and capsulated into potato starch to produce nanocapsules (Ni‐NPs@s ...
DOI:
10.1002/star.202100165

48. Synthesis of agelastatin A and derivatives premised on a hidden symmetry element leading to analogs displaying anticancer activity

Author:
Haoran Xue; Haleigh Svatek; Ariane F. Bertonha; Keighley Reisenauer; Joshua Robinson; Minwoo Kim; Alec Ingros; Matthew Ho; Joseph Taube; Daniel Romo
Source:
Tetrahedron 2021 v.94 pp. 132340
ISSN:
0040-4020
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; cell lines; cytotoxicity; glioblastoma; moieties; pyrroles; solubility
Abstract:
... Concise total syntheses of (±)-7-hydroxy debromo agelastatin A (AglA), (±)-AglA, and 11-nitro AglA are presented based on an identified pseudo-symmetry element. This synthetic strategy was developed based on a desire to improve solubility of this potent anticancer agent while also developing a synthetic strategy that would enable late-stage variation of the pyrrole moiety. A stability study of pyr ...
DOI:
10.1016/j.tet.2021.132340

49. Synthesis of novel heterocyclic compounds based on dialdehyde cellulose: characterization, antimicrobial, antitumor activity, molecular dynamics simulation and target identification

Author:
Mohamed Hasanin; Amr H. Hashem; Ahmed A. El-Rashedy; Samir Kamel
Source:
Cellulose 2021 v.28 no.13 pp. 8355-8374
ISSN:
0969-0239
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; Pseudomonas aeruginosa; Staphylococcus aureus; X-radiation; antimicrobial properties; antineoplastic activity; cell lines; cellulose; hydrazides; molecular dynamics; schiff bases
Abstract:
... In this study, new amino heterocyclic cellulose derivatives were prepared. Dialdehyde cellulose was functionalized by Schiff base reaction with (E)-2-(4-(dimethylamino) benzylidene)-4-oxo-4-phenylbutanehydrazide, (E)-2-((1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-4-phenylbutane hydrazide, and thiophene-2-carbohydrazide. The prepared derivatives were characterized and confirmed by Fourier-transform infrar ...
DOI:
10.1007/s10570-021-04063-7

50. The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells

Author:
Menna El Gaafary; Fatema R. Saber; Engy A. Mahrous; Rehab M. Ashour; Mona M. Okba; Lu Jin; Sophia J. Lang; Michael Schmiech; Thomas Simmet; Tatiana Syrovets
Source:
Food and chemical toxicology 2022 v.162 pp. 112896
ISSN:
0278-6915
Subject:
Callistemon citrinus; antineoplastic activity; apoptosis; breast neoplasms; cell lines; chicks; computer simulation; interphase; membrane potential; mitochondria; mortality; neoplasm cells; oxidative phosphorylation; oxidoreductases; toxicity; toxicology; ubiquinones; xenotransplantation
Abstract:
... Breast cancer is the most common cancer and the leading cause of cancer-related mortality among females worldwide. From the leaves of Callistemon citrinus, we have isolated a novel phloroglucinol dimer, calcitrinone A, and analyzed its potential anticancer activity using the triple-negative breast cancer cell line MDA-MB-231. Calcitrinone A decreased the total intracellular ATP levels, inhibited p ...
DOI:
10.1016/j.fct.2022.112896

51. The pro-apoptotic and cytotoxic efficacy of polydatin encapsulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles

Author:
Sankaran Vijayalakshmi; Aruliah Rajasekar; Vishnu Priya Veeraraghavan; Alaa Yousef Ghidan; Tawfiq M. Al Antary; Venkatachalam Karthikkumar; Lakshmi Priya Malarveni Damodaran; Ramachandran Vinayagam; Ernest David
Source:
Process biochemistry 2021 v.111 pp. 210-218
ISSN:
1359-5113
Subject:
DNA; DNA damage; acridine orange; antineoplastic activity; apoptosis; cell lines; cell proliferation; cell viability; cytotoxicity; encapsulation; ethidium; ingredients; lipid peroxidation; membrane potential; mitochondrial membrane; oxidative stress; reactive oxygen species
Abstract:
... Polydatin (POL) is an ingredient of many herbal medications and has pharmacological properties. The present study aimed to determine the antitumor potential of Polydatin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (POL-PLGA-NPs) against the cancerous KB cell line. We evaluated the efficiency of synthesized nanoparticles on cell proliferation and apoptosis markers, in addition to the ...
DOI:
10.1016/j.procbio.2021.10.033

52. The proteomic landscape of ovarian cancer cells in response to melatonin

Author:
Roberta Carvalho Cesário; Leticia Barbosa Gaiotte; Maira Smaniotto Cucielo; Henrique Spaulonci Silveira; Lucilene Delazari dos Santos; Debora Aparecida Pires de Campos Zuccari; Fábio Rodrigues Ferreira Seiva; Russel J. Reiter; Luiz Gustavo de Almeida Chuffa
Source:
Life sciences 2022 v.294 pp. 120352
ISSN:
0024-3205
Subject:
antineoplastic activity; cell lines; cytotoxicity; equipment; humans; immune response; immune system; liquids; mass spectrometry; melatonin; mitochondria; ovarian neoplasms; pineal body; prognosis; protein synthesis; proteome; proteomics; ribosomal proteins; therapeutics; tricarboxylic acid cycle
Abstract:
... Ovarian cancer (OC) is the most lethal gynecological malignancy with a highly negative prognosis. Melatonin is an indoleamine secreted by the pineal gland during darkness and has shown antitumor activity in both in vitro and in vivo experiments. Herein, we investigated the influence of melatonin on the proteome of human ovarian carcinoma cells (SKOV-3 cell line) using the Ultimate 3000 LC Liquid N ...
DOI:
10.1016/j.lfs.2022.120352

53. UV-visible light-induced photochemical synthesis of benzimidazoles by coomassie brilliant blue coated on W–ZnO@NH₂ nanoparticles

Author:
Ruijuan Chen; Zahra Jalili; Reza Tayebee
Source:
RSC advances 2021 v.11 no.27 pp. 16359-16375
ISSN:
2046-2069
Subject:
air; antineoplastic activity; benzimidazoles; breast neoplasms; cell lines; cytotoxicity; energy; energy conservation; filtration; green chemistry; lamps; nanocatalysts; nanohybrids; oxidants; photocatalysis; photocatalysts; toxicity testing
Abstract:
... Heterogeneous photocatalysts proffer a promising method to actualize eco-friendly and green organic transformations. Herein, a new photochemical-based methodology is disclosed in the preparation of a wide range of benzimidazoles through condensation of o-phenylenediamine with benzyl alcohols in the air under the illumination of an HP mercury lamp in the absence of any oxidizing species catalyzed b ...
DOI:
10.1039/d0ra10843j

54. Variations in the Anticancer Activity of Free and Bound Phenolics of Finger Millet (Eleusine coracana (L) Gaertn; Variety KMR-301) Seeds

Author:
Mahadevaswamy G. Kuruburu; Venugopal R. Bovilla; Rimshia Naaz; Zonunsiami Leihang; SubbaRao V. Madhunapantula
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100276
ISSN:
2667-0313
Subject:
4',6-diamidino-2-phenylindole; DNA; Eleusine coracana subsp. coracana; acridine orange; amino acids; antineoplastic activity; antioxidant activity; breast neoplasms; breasts; cakes; calcium; cell cycle; cell death; cell lines; cell proliferation; colon; colorectal neoplasms; cytotoxicity; dietary fiber; ethanol; ethidium; flavonoids; fluorescence microscopes; malt; neoplasm cells; porridge; rectum; rice cakes; savory; seeds; Africa; India
Abstract:
... Finger millet (FM, Eleusine coracana (L) Gaertn; also known as “ragi” in Kannada language) is one of the widely used millets especially in south India and parts of Africa. FM is consumed in various forms that include porridge, mudde (ball), dosa (a pan cake), idly (a savory rice cake) and biscuits/cookies. FM is also used in the form of malted drink known as “malted ragi or ragi malt”. FM is a ric ...
DOI:
10.1016/j.phyplu.2022.100276

55. 2D-QSAR and docking study of a series of coumarin derivatives as inhibitors of CDK (anticancer activity) with an application of the molecular docking method

Author:
Rania Kasmi; Elghalia Hadaji; Oussama Chedadi; Abdellah El Aissouq; Mohammed Bouachrine; Abdelkrim Ouammou
Source:
Heliyon 2020 v.6 no.8 pp. e04514
ISSN:
2405-8440
Subject:
antineoplastic activity; cell lines; computer software; coumarin; drug design; drugs; hydrogen bonding; models; quantitative structure-activity relationships; regression analysis; synthesis
Abstract:
... Quantitative Structure Activity Relationship (QSAR) analysis techniques are tools largely utilized in many research fields, including drug discovery processes.In this work electronic descriptors are calculated with the Gaussian 03W software using the DFT method with the BecKe 3-parameters exchange functional and Lee-Yang-Parr correlation functional, with Kohn and Sham orbitals (KS) developed on a ...
DOI:
10.1016/j.heliyon.2020.e04514

56. A Comparative Antibacterial, Antioxidant, and Antineoplastic Potential of Rauwolfia serpentina (L.) Leaf Extract with Its Biologically Synthesized Gold Nanoparticles (R-AuNPs)

Author:
Mohammad Y. Alshahrani; Zeeshan Rafi; Nadiyah M. Alabdallah; Ambreen Shoaib; Irfan Ahmad; Mohammed Asiri; Gaffar Sarwar Zaman; Shadma Wahab; Mohd Saeed; Salman Khan
Source:
Plants 2021 v.10 no.11 pp. -
ISSN:
2223-7747
Subject:
Bacillus subtilis; Escherichia coli; Gram-negative bacteria; Proteus vulgaris; Rauvolfia serpentina; Staphylococcus aureus; Streptococcus pyogenes; amoxicillin; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; cell lines; encapsulation; humans; inhibitory concentration 50; leaf extracts; medicinal plants; nanogold; transmission electron microscopy; ultraviolet-visible spectroscopy; uterine cervical neoplasms; zeta potential
Abstract:
... Rauwolfia serpentina (R. serpentina), belonging to the family Apocynaceae, is a renowned medicinal herb for its different pharmacological activities such as antibacterial, antifungal, anti-inflammatory, and antiproliferative characteristics. This study has done a comparative assessment of the antibacterial, antioxidant, and anti-cancer activity of R. serpentina aqueous leaf extract (RSALE) with en ...
DOI:
10.3390/plants10112278

57. A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity

Author:
Carmela Gallo; Giusi Barra; Marisa Saponaro; Emiliano Manzo; Laura Fioretto; Marcello Ziaco; Genoveffa Nuzzo; Giuliana d’Ippolito; Raffaele De Palma; Angelo Fontana
Source:
Marine drugs 2020 v.18 no.12 pp. -
ISSN:
1660-3397
Subject:
T-lymphocytes; adaptive immunity; antineoplastic activity; bioassays; cell lines; dendritic cells; design; drugs; extracts; humans; immune response; immunotherapy; libraries; mice; neoplasm cells; phenotype; research
Abstract:
... Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for the preclinical discovery of anticancer candidates. The platform relies on the us ...
DOI:
10.3390/md18120604

58. A combination index and glycoproteomics-based approach revealed synergistic anticancer effects of curcuminoids of turmeric against prostate cancer PC3 cells

Author:
Meng-Meng Wei; Shu-Juan Zhao; Xue-Man Dong; Yong-Jie Wang; Can Fang; Pu Wu; Gao-Qian Song; Jun-Na Gao; Zhi-Hui Huang; Tian Xie; Jian-Liang Zhou
Source:
Journal of ethnopharmacology 2021 v.267 pp. 113467
ISSN:
0378-8741
Subject:
Curcuma longa; Western blotting; additive effect; antineoplastic activity; apoptosis; biosynthesis; cancer therapy; cell cycle; cell lines; cell viability; curcumin; gluconeogenesis; glycolysis; glycoproteomics; mass spectrometry; neoplasm cells; prostatic neoplasms; rhizomes; ribosomes; synergism; turmeric
Abstract:
... Herbal medicines (HMs) often exert integration effects, including synergistic, additive and antagonistic effects, in such ways that they act on multiple targets and multiple pathways on account of their multiple components. Turmeric, made from the rhizome of Curcuma longa L., is a well-known HM prescribed in the polyherbal formulas for cancer treatment in traditional Chinese medicines (TCMs). Howe ...
DOI:
10.1016/j.jep.2020.113467

59. Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Author:
Rumiana Tzoneva; Veselina Uzunova; Tihomira Stoyanova; Borislava Borisova; Albena Momchilova; Roumen Pankov; Liliana Maslenkova
Source:
Biotechnology & Biotechnological Equipment 2021 v.35 no.1 pp. 853-861
ISSN:
1314-3530
Subject:
Petasites hybridus; antineoplastic activity; apoptosis; biotechnology; breast neoplasms; cell lines; cytotoxicity; dose response; equipment; humans; neoplasm cells; root extracts; viability
Abstract:
... In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72 h treatment. We found the highest cytotoxicity of BE to ...
DOI:
10.1080/13102818.2021.1932594

60. Anticancer, anticholinesterase and antidiabetic activities of tunceli garlic (Allium tuncelianum): determining its phytochemical content by LC–MS/MS analysis

Author:
Kasim Takim; Akin Yigin; Ismail Koyuncu; Ruya Kaya; İlhami Gülçin
Source:
Journal of food measurement & characterization 2021 v.15 no.4 pp. 3323-3335
ISSN:
2193-4126
Subject:
Allium; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell lines; cytotoxicity; diabetes; enzyme inhibition; enzyme inhibitors; flow cytometry; garlic; genes; humans; interleukin-6; interleukin-8; liquid chromatography; malic acid; measurement; methanol; phytochemicals; prostatic neoplasms; quantitative polymerase chain reaction; quinic acid
Abstract:
... We aimed to investigate the phytochemical content and pharmaceutical activity of methanol extracts of Allium tuncelianum (MAT). In this study, phytochemical contents of MAT were analyzed by liquid chromatography mass-spectrometry (LC–MS/MS) technique. Anticancer activity was determined on six different cell lines. By flow cytometric method, apoptotic activity was examined with annexin V in human p ...
DOI:
10.1007/s11694-021-00912-y

61. Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Author:
Nikoleta Stoyanova; Mariya Spasova; Nevena Manolova; Iliya Rashkov; Ani Georgieva; Reneta Toshkova
Source:
Antioxidants 2020 v.9 no.3 pp. -
ISSN:
2076-3921
Subject:
2,2-diphenyl-1-picrylhydrazyl; X-ray diffraction; antineoplastic activity; antioxidant activity; bioactive compounds; cell lines; cellulose; cellulose acetate; contact angle; cytotoxicity; differential scanning calorimetry; free radical scavengers; hydrophilicity; in vitro studies; infrared spectroscopy; melanoma; neoplasm cells; polyethylene glycol; quercetin; scanning electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several methods including scanning electron microscopy (SEM), IR spectroscopy, X-ray diffraction analysis (XRD), water contact angle measurements, differential scanning calorimetry (DSC), and UV-VIS spect ...
DOI:
10.3390/antiox9030232

62. Antioxidant and antibacterial activities of Artemisia absinthium and Citrus paradisi extracts repress viability of aggressive liver cancer cell line [Erratum: April 2022, v.49(4); p.3367]

Author:
Muhammad Ali; Rida Iqbal; Muhammad Safdar; Sehrish Murtaza; Ghulam Mustafa; Muhammad Sajjad; Shazia Anwer Bukhari; Tayyaba Huma
Source:
Molecular biology reports 2021 v.48 no.12 pp. 7703-7710
ISSN:
0301-4851
Subject:
Artemisia absinthium; Citrus paradisi; Escherichia coli; Klebsiella pneumoniae; Salmonella enterica; Staphylococcus aureus; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; disk diffusion antimicrobial test; flavonoids; liver; liver neoplasms; molecular biology; neoplasm cells; viability
Abstract:
... BACKGROUND: Numerous reports show that herbal medicines can be utilized in the treatment of different liver disorders. In this study, antioxidant, antibacterial, and anticancer activities of individual as well as combined 80% ethanolic extracts of Artemisia absinthium leaves and Citrus paradisi peels were investigated. METHODS AND RESULTS: Values of total phenolic contents (TPC), total flavonoid c ...
DOI:
10.1007/s11033-021-06777-0

63. Antioxidant and antitumoral activities of isolated macamide and macaene fractions from Lepidium meyenii (Maca)

Author:
Ling Fu; Jinchao Wei; Yumei Gao; Rui Chen
Source:
Talanta 2021 v.221 pp. 121635
ISSN:
0039-9140
Subject:
Lepidium meyenii; adverse effects; amides; antineoplastic activity; antioxidant activity; breast neoplasms; cancer therapy; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; drugs; free radical scavengers; leukemia; liver neoplasms; lung neoplasms; neoplasm cells; paper
Abstract:
... In this paper, a UPLC-ESI-MS was established to analyze macamide and macaene fractions from Lepidium meyenii (Maca). The antioxidant activity of Maca crude extract (MCE), total macamides (TMM) and total macaenes (TME) was evaluated by DPPH radical scavenging, ABTS radical scavenging and reducing power. The ability of MCE, TMM and TME against multiple cancer cell lines (leukemia HL-60, lung cancer ...
DOI:
10.1016/j.talanta.2020.121635

64. Antioxidant profile at the different stages of craft beers production: the role of phenolic compounds

Author:
Priscila Aparecida Horn; Natalia Bagattoli Pedron; Lucas Henrique Junges; Andrey Martinez Rebelo; Hercílio Higino da Silva Filho; Ana Lúcia Bertarello Zeni
Source:
European food research & technology 2021 v.247 no.2 pp. 439-452
ISSN:
1438-2377
Subject:
adenocarcinoma; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; beers; biobased products; catechin; cell lines; cell viability; colon; cytotoxicity; fibroblasts; food research; human health; neoplasm cells; spent grains; yeasts
Abstract:
... The antioxidant composition from four samples, brewer’s spent grain (BSG), brewer’s spent yeast (BRY), a part of the process (POP—after hop addition), and craft beer (CRB) from five popular craft beers were evaluated. The total phenolics, flavonoids, tannins, and ascorbic acid, as well as the antioxidant capacity, were determined. Furthermore, phenolics content was determined by LC–MS/MS technique ...
DOI:
10.1007/s00217-020-03637-2

65. Antiproliferative Rapeseed Defatted Meal Protein and Their Hydrolysates on MCF-7 Breast Cancer Cells and Human Fibroblasts

Author:
Romina L. Ferrero; Carmen Soto-Maldonado; Caroline Weinstein-Oppenheimer; Zaida Cabrera-Muñoz; María Elvira Zúñiga-Hansen
Source:
Foods 2021 v.10 no.2 pp. -
ISSN:
2304-8158
Subject:
agroindustrial byproducts; antineoplastic activity; breast neoplasms; cell lines; enzymatic hydrolysis; fibroblasts; humans; hydrolysates; hydrolysis; neoplasm cells; peptides; polyacrylamide gel electrophoresis; protein content; protein isolates; proteinases; rapeseed; rapeseed meal; rapeseed protein; research; solubilization
Abstract:
... Defatted rapeseed meal (DRM) is a sub-valorized agro-industrial by-product, with a high protein content whose peptides could have potential anticancer activity against cancer cell lines. The objective of the present study is to obtain an enzymatic hydrolysate of rapeseed protein that inhibits proliferation on a breast cancer cell line (MCF-7), but not healthy human fibroblast cells. The DRM was so ...
DOI:
10.3390/foods10020309

66. Antiproliferative diterpenoids and acetophenone glycoside from the roots of Euphorbia fischeriana

Author:
Kaicheng Du; Xinyong Yang; Jiaheng Li; Dali Meng
Source:
Phytochemistry 2020 v.177 pp. 112437
ISSN:
0031-9422
Subject:
Euphorbia fischeriana; acetophenones; antineoplastic activity; assays; cell lines; diterpenoids; glycosides; liver neoplasms; moieties; plant biochemistry; roots
Abstract:
... Three undescribed compounds and nine known compounds were isolated from the Euphorbia fischeriana Steud. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and HRESIMS data. The absolute configurations of two undescribed diterpenoids were determined by comparing their experimental and calculated ECD data. To further understand the antitumor effects of E. fischerian ...
DOI:
10.1016/j.phytochem.2020.112437

67. Antitumor Activity of Indole-3-carbinol in Breast Cancer Cells: Phenotype, Genetic Pattern, and DNA Methylation Inversion

Author:
A. A. Poloznikov; E. L. Muyzhnek; S. V. Nikulin; A. D. Kaprin; L. A. Ashrafyan; N. I. Rozhkova; P. G. Labazanova; V. I. Kiselev
Source:
Applied biochemistry and microbiology 2020 v.56 no.9 pp. 909-919
ISSN:
0003-6838
Subject:
DNA; DNA methylation; antineoplastic activity; breast neoplasms; cell lines; epigenetics; genes; microbiology; phenotype
Abstract:
... The effect of indole-3-carbinol on the proliferation and migration of MDA-MB-231 breast-cancer cells and healthy MCF-10A breast-tissue cells has been studied. It was shown that indole-3-carbinol reliably reduced the proliferation and migration of MDA-MB-231 cells and does not significantly affect MCF-10A cells. The incubation of MDA-MB-231 tumor cells with 100 μM indole-3-carbinol for 48 h resulte ...
DOI:
10.1134/S0003683820090070

68. Antitumoral effects of fucoidan on bladder cancer

Author:
C.C.F. do-Amaral; B.S. Pacheco; F.K. Seixas; C.M.P. Pereira; T. Collares
Source:
Algal research 2020 v.47 pp. 101884
ISSN:
2211-9264
Subject:
Phaeophyceae; adverse effects; antineoplastic activity; apoptosis; biochemical pathways; cancer therapy; cell lines; chemical structure; dietary supplements; drug therapy; fucoidan; models; neoplasm cells; patients; urinary bladder neoplasms
Abstract:
... Fucoidans are natural compounds derived from brown algae that are known for various biological activities. The mechanisms underlying these activities are being widely studied and are not yet fully understood. The results obtained so far have pointed to fucoidans being promising molecules capable of serving as an adjunct to anticancer therapy, or even as dietary supplementation in cancer patients. ...
DOI:
10.1016/j.algal.2020.101884

69. Anti‐gastric cancer activity and mechanism of natural compound “Heilaohulignan C” isolated from Kadsura coccinea

Author:
Muhammad Daniyal; Yongbei Liu; Yupei Yang; Feng Xiao; Jialong Fan; Huanghe Yu; Yixing Qiu; Bin Liu; Wei Wang; Qin Yuhui
Source:
Phytotherapy research 2021 v.35 no.7 pp. 3977-3987
ISSN:
0951-418X
Subject:
Kadsura coccinea; Western blotting; antineoplastic activity; apoptosis; carcinoma; caspase-3; cell lines; cell movement; cytotoxicity; flow cytometry; humans; mitochondria; phytotherapy; propidium; protein content; research; stomach neoplasms; xenotransplantation
Abstract:
... In this research, we analyzed the antitumor activity of one new compound Heilaohulignan C (B‐6) on the human gastric carcinoma cells. MTT, cell migration, Calcein AM/Propidium Iodide (PI), and flow cytometry in BGC‐823 cell line (gastric tumor). Western blot was utilized to distinguish the protein level. Xenografts nude mice were used for in vivo anticancer analysis. H&E staining and laboratory in ...
DOI:
10.1002/ptr.7114

70. Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro

Author:
Ridhima Wadhwa; Keshav Raj Paudel; Li Hian Chin; Chian Ming Hon; Thiagarajan Madheswaran; Gaurav Gupta; Jithendra Panneerselvam; Thangavelu Lakshmi; Sachin Kumar Singh; Monica Gulati; Harish Dureja; Alan Hsu; Meenu Mehta; Krishnan Anand; Hari Prasad Devkota; Jestin Chellian; Dinesh Kumar Chellappan; Philip M. Hansbro; Kamal Dua
Source:
Journal of food biochemistry 2021 v.45 no.1 pp. e13572
ISSN:
0145-8884
Subject:
anti-inflammatory activity; antineoplastic activity; apoptosis; carcinoma; cell lines; drugs; epithelium; humans; inflammation; interleukin-6; interleukin-8; liquids; lung neoplasms; lungs; naringenin; propionic acid; therapeutics
Abstract:
... In this study, we had developed Naringenin‐loaded liquid crystalline nanoparticles (LCNs) and investigated the anti‐inflammatory and anticancer activities of Naringenin‐LCNs against human airway epithelium‐derived basal cells (BCi‐NS1.1) and human lung epithelial carcinoma (A549) cell lines, respectively. The anti‐inflammatory potential of Naringenin‐LCNs evaluated by qPCR revealed a decreased exp ...
DOI:
10.1111/jfbc.13572

71. Aqueous Extract of Moringa oleifera Exhibit Potential Anticancer Activity and can be Used as a Possible Cancer Therapeutic Agent: A Study Involving In Vitro and In Vivo Approach

Author:
Dharmeswar Barhoi; Puja Upadhaya; Sweety Nath Barbhuiya; Anirudha Giri; Sarbani Giri
Source:
Journal of the American College of Nutrition 2021 v.40 no.1 pp. 70-85
ISSN:
1541-1087
Subject:
Moringa oleifera; adverse effects; alpha-tocopherol; antineoplastic activity; apoptosis; bioactive compounds; cancer therapy; carcinoma; cell cycle; cell lines; cytotoxicity; flow cytometry; humans; larynx; liver; longevity; membrane potential; mitochondrial membrane; neoplasm progression; nutrition; palmitic acid; quinic acid; remission; renal function; stearic acid
Abstract:
... New cases of cancers are increasing at an alarming rate globally. It has been hypothesized that modern cancer treatment is associated with lots of side effects and thus evoking the need to develop safer treatment measures. Thus, the present study was undertaken to evaluate the anti-carcinogenic potential of a highly nutricious plant “Moringa oleifera” (MO) in vitro and in vivo. GC-MS analysis of a ...
DOI:
10.1080/07315724.2020.1735572

72. Avicennia marina engineered nanoparticles induce apoptosis in adenocarcinoma lung cancer cell line through p53 mediated signaling pathways

Author:
Krishnamoorthy Varunkumar; Chidambaram Anusha; Thavamani Saranya; Vaikundamoorthy Ramalingam; Sakthivel Raja; Vilwanathan Ravikumar
Source:
Process biochemistry 2020 v.94 pp. 349-358
ISSN:
1359-5113
Subject:
Avicennia marina; absorption; adenocarcinoma; antineoplastic activity; apoptosis; caspases; cell lines; cytotoxicity; dose response; fluorescence; lung neoplasms; mitochondria; mitochondrial membrane; nanosilver; neoplasm cells; silver; spectral analysis; therapeutics
Abstract:
... The biogenic engineered silver nanoparticles (AgNPs) were synthesized using aqueous extract of marine mangrove Avicennia marina leaves and its anticancer activity was checked in lung cancer cell line. Initially, the UV–vis spectra exhibited the characteristics SPR absorption peak for AgNPs at 425 nm and further characterized using TEM, SAED, XRD and FT-IR analysis. The TEM pictures displayed the s ...
DOI:
10.1016/j.procbio.2020.04.034

73. BF175 inhibits endometrial carcinoma through SREBP-regulated metabolic pathways in vitro

Author:
Qiong Wang; Ruofan Hu; Weihua Li; Yanhong Tai; Weiting Gu; Bhaskar C. Das; Fajun Yang; Junyuan Ji; Chenguang Wang; Jie Zhou
Source:
Molecular and cellular endocrinology 2021 v.523 pp. 111135
ISSN:
0303-7207
Subject:
antineoplastic activity; apoptosis; autophagy; biochemical pathways; carcinoma; cell lines; cell viability; cholesterol; endocrinology; endometrium; free fatty acids; genes; lipogenesis; microarray technology; migratory behavior; mitochondria; therapeutics
Abstract:
... Elevated lipogenesis is an important metabolic hallmark of rapidly proliferating tumor such as endometrial carcinoma (EC). The sterol regulatory element-binding protein 1 (SREBP1) is a master regulator of lipogenesis and involved in EC proliferation. BF175 is a novel chemical inhibitor of SREBP pathway, and has shown potent anti-lipogenic effects. However, the effect of BF175 on EC cells are yet t ...
DOI:
10.1016/j.mce.2020.111135

74. Bavachinin Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Small Cell Lung Cancer and Shows an Antitumor Effect in the Xenograft Model

Author:
Shih-Ya Hung; Shih-Chao Lin; Shuzhen Wang; Tzu-Jung Chang; Yu-Tang Tung; Chi-Chien Lin; Chi-Tang Ho; Shiming Li
Source:
Journal of agricultural and food chemistry 2021 v.69 no.22 pp. 6260-6270
ISSN:
1520-5118
Subject:
Cullen corylifolium; antineoplastic activity; apoptosis; caffeine; caspase-3; cell cycle checkpoints; cell lines; dose response; food chemistry; humans; immunomodulation; lung neoplasms; models; neoplasm cells; prognosis; viability; xenotransplantation
Abstract:
... Lung cancer is grouped into small cell lung cancer (SCLC) and non-SCLC (NSCLC). SCLC exhibits a poor prognosis, and the current anticancer treatment remains unsatisfactory. Bavachinin, present in the seed of Psoralea corylifolia, shows anti-inflammatory effects, immune modulation, and anticancer potency. This study aims to investigate the antitumor effect of bavachinin on SCLC and its underlying m ...
DOI:
10.1021/acs.jafc.1c01657

75. Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy

Author:
Beata Tylińska; Benita Wiatrak
Source:
Biology 2021 v.10 no.6 pp. -
ISSN:
2079-7737
Subject:
alkaloids; antineoplastic activity; antineoplastic agents; cancer therapy; carbazoles; cell lines; in vitro studies; in vivo studies; structure-activity relationships
Abstract:
... Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of these compounds was tested on cell lines of various tumors. In most publications, the most active olivacine derivatives exceeded the effects of doxorubi ...
DOI:
10.3390/biology10060564

76. Biomedical Applications of Mycosynthesized Selenium Nanoparticles Using Penicillium expansum ATTC 36200

Author:
Amr Hosny Hashem; Ahmed Mohamed Aly Khalil; Ahmed M. Reyad; Salem S. Salem
Source:
Biological trace element research 2021 v.199 no.10 pp. 3998-4008
ISSN:
0163-4984
Subject:
Aspergillus fumigatus; Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Penicillium expansum; Pseudomonas aeruginosa; Staphylococcus aureus; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; biosynthesis; cell lines; humans; research; selenium
Abstract:
... In this study, green and eco-friendly biosynthesis of selenium nanoparticles (Se-NPs) were performed using Penicillium expansum ATTC 36200 for multiple biomedical applications. Mycosynthesized Se-NPs were completely characterized using UV, FT-IR, XRD, SEM, and TEM techniques. Se-NPs biosynthesized by P. expansum was characterized as a spherical shape with average size 4 to 12.7 nm. Moreover, Se-NP ...
DOI:
10.1007/s12011-020-02506-z

77. Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7

Author:
Amani Ghassan Al-Nuairi; Kareem A. Mosa; Mohammad G. Mohammad; Ali El-Keblawy; Sameh Soliman; Hussain Alawadhi
Source:
Biological trace element research 2020 v.194 no.2 pp. 560-569
ISSN:
0163-4984
Subject:
Cyperus; Fourier transform infrared spectroscopy; X-ray diffraction; antineoplastic activity; apoptosis; biosynthesis; breast neoplasms; cell lines; cytotoxicity; dunes; energy-dispersive X-ray analysis; fibroblasts; genes; inhibitory concentration 50; light scattering; nanoparticles; nanosilver; neoplasm cells; quantitative polymerase chain reaction; root extracts; scanning electron microscopes; staining; xerophytes
Abstract:
... Over recent years, metal nanoparticles have largely been investigated due to their potential activities. This study focused on synthesizing silver nanoparticles (AgNPs) using the desert plant Cyperus conglomeratus, which is the most abundant species on the sand dunes in the UAE, and their anticancer activity. The synthesized AgNPs were characterized using UV-visible spectra, X-ray diffraction, ene ...
DOI:
10.1007/s12011-019-01791-7

78. Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus)

Author:
Yu-Lin Dai; Eun-A Kim; Hao-Ming Luo; Yun-Fei Jiang; Jae-Young Oh; Soo-Jin Heo; You-Jin Jeon
Source:
Journal of food science and technology 2020 v.57 no.6 pp. 2283-2292
ISSN:
0022-1155
Subject:
Apostichopus japonicus; B-cell lymphoma; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell lines; inhibitory concentration 50; mass spectrometry; neoplasm cells; saponins; ultra-performance liquid chromatography; Red Sea; South Korea
Abstract:
... In this study, the saponin-rich fractions of five individual (two Red and three Black) sea cucumbers (Apostichopus japonicus) in South Korea were investigated for their antiproliferative effect against HL-60, B16F10, MCF-7, and Hep3B tumor cell lines. The red sea cucumber saponin-rich fraction (SSC) from Jeju Island (JRe) decreased the growth of HL-60 with an IC₅₀ value of 23.55 ± 3.40 μg/mL, whic ...
DOI:
10.1007/s13197-020-04266-z

79. Chemical Composition of Essential Oil of Cananga odorata (Lam.) Hook. F. & Thomson Leaves and Its Biological Activities

Author:
Krishnasamy Vimaladevi; Madhiyan Selladurai; Kathirvel Poonkodi; Velliangiri Prabhu; Raman Mini; Balasubramaniyam Manojkumar
Source:
Journal of essential oil-bearing plants 2021 v.24 no.3 pp. 596-602
ISSN:
0976-5026
Subject:
Cananga odorata; acetone; antineoplastic activity; antioxidants; benzyl benzoate; cell lines; chemical composition; essential oils; farnesol; leaves; ocimene; oils; sesquiterpenoids
Abstract:
... In the current study, the chemical constituents of leaf essential oil from Cananga odorata (Lam.) Hook. F. & Thomson were identified by GC/MS analysis. A total of 25 components (91.1 %) in the essential oil were identified. The major compounds present in the oil were trans-caryophyllene (19.7 %), ocimene (13.2 %), E, E-α-farnesene (10.3 %), phenylmethyl ester (5.6 %), farnesyl acetone (5.1 %), t-m ...
DOI:
10.1080/0972060X.2021.1957023

80. Chemical profiling and bioactivity of essential oils from Alpinia officinarum Hance from ten localities in China

Author:
Lanyue Zhang; Chunxing Pan; Zhirong Ou; Xiaoxin Liang; Yaohui Shi; Lejing Chi; Zejun Zhang; Xi Zheng; Chunlian Li; Hongping Xiang
Source:
Industrial crops and products 2020 v.153 pp. 112583
ISSN:
0926-6690
Subject:
Alpinia officinarum; Gram-positive bacteria; additives; alpha-terpineol; anti-inflammatory activity; antibacterial properties; antineoplastic activity; cell lines; cineole; drugs; ears; edema; essential oils; gas chromatography-mass spectrometry; habitats; herbs; inhibitory concentration 50; interleukin-1beta; mice; nutrition; rhizomes; tumor necrosis factor-alpha; China
Abstract:
... Essential oil of herbs has natural bioactivity, which can be applied on biomedical products, pharmaceutical preparations, natural functional nutrition and cosmetic additives. The chemical components and bioactivities of essential oils extracted from Alpinia officinarum Hance rhizomes collected from ten various habitats in China were comparatively investigated. The yield of ten essential oils varie ...
DOI:
10.1016/j.indcrop.2020.112583

81. Chrysin-loaded bovine serum albumin particles as bioactive nanosupplements

Author:
Joana B. Ferrado; Adrián A. Perez; Maria C. Ruiz; Ignacio E. León; Liliana G. Santiago
Source:
Food & function 2020 v.11 no.7 pp. 6007-6019
ISSN:
2042-650X
Subject:
antineoplastic activity; bioactive compounds; bovine serum albumin; cell death; cell lines; chrysin; cytotoxicity; diet; digestion; encapsulation; exhibitions; flow cytometry; freeze drying; in vitro digestion; incidence; information; models; nanoparticles; neoplasm cells; pH; particles; powders; protocols; toxicity testing; turbidity; water solubility
Abstract:
... Development of nanosupplements based on bioactive compound encapsulation and their incorporation into diet constitutes a field that is growing exponentially. Among flavonoids, chrysin (Chrys) shows high antitumor activity but its poor water solubility limits its applications. Bovine serum albumin nanoparticles (BSAnp) with sizes in the range of 13–28 nm were previously prepared by applying a heat- ...
DOI:
10.1039/d0fo00299b

82. Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells

Author:
Basma Al-Sudani; Abby H. Ragazzon-Smith; Athar Aziz; Rania Alansari; Natalie Ferry; Marija Krstic-Demonacos; Patricia A. Ragazzon
Source:
RSC advances 2020 v.10 no.73 pp. 45008-45018
ISSN:
2046-2069
Subject:
DNA; RNA; antineoplastic activity; cell lines; cell viability; death; enzyme activity; fluorescence microscopy; histone deacetylase; humans; ligands; metabolism; neoplasm cells; oligonucleotides; systematic evolution of ligands by exponential enrichment; toxicity; viability assays
Abstract:
... It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information regulator 1 (SIRT1) – a histone deacetylase – has shown many roles in cancer, ageing and metabolism. Here we report novel SIRT1 ligands that bind and mo ...
DOI:
10.1039/d0ra07857c

83. Cobalt(I)-catalyzed [6π+2π]-cycloaddition of allenes to N-carbethoxy(phenoxy)azepines for the synthesis of 9-azabicyclo[4.2.1]nona-2,4-dienes

Author:
Gulnara N. Kadikova; Vladimir A. D’yakonov; Ramil N. Nasretdinov; Lilya U. Dzhemileva; Usein M. Dzhemilev
Source:
Tetrahedron 2020 v.76 no.10 pp. 130996
ISSN:
0040-4020
Subject:
X-ray diffraction; antineoplastic activity; azepines; catalytic activity; cell lines; chemical reactions; chemical structure; cobalt; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; zinc
Abstract:
... The [6π+2π]-cycloaddition of allenes to N-carbethoxyazepine or N-carbophenoxyazepine catalyzed by the Co(acac)₂(dppe)/Zn/ZnI₂ system was performed for the first time and gave previously unknown substituted 9-azabicyclo[4.2.1]nona-2,4-dienes and 16-azatricyclo[9.4.1.0²,¹⁰]hexadeca-2,12,14-trienes in 75–95% yields. The structures of the resulting azacyclic compounds were reliably proved using NMR sp ...
DOI:
10.1016/j.tet.2020.130996

84. Combined Anticancer Effect of Sulfated Laminaran from the Brown Alga Alaria angusta and Polyhydroxysteroid Glycosides from the Starfish Protoreaster lincki on 3D Colorectal Carcinoma HCT 116 Cell Line

Author:
Olesya S. Malyarenko; Timofey V. Malyarenko; Roza V. Usoltseva; Valerii V. Surits; Alla A. Kicha; Natalia V. Ivanchina; Svetlana P. Ermakova
Source:
Marine drugs 2021 v.19 no.10 pp. -
ISSN:
1660-3397
Subject:
Alaria; Asteroidea; agar; antineoplastic activity; apoptosis; cancer therapy; cell culture; cell lines; colorectal neoplasms; glycosides; mechanism of action; models; non-specific serine/threonine protein kinase; synergism; viability
Abstract:
... Colorectal cancer is one of the most frequent types of malignancy in the world. The search for new approaches of increasing the efficacy of cancer therapy is relevant. This work was aimed to study individual, combined anticancer effects, and molecular mechanism of action of sulfated laminaran AaLs of the brown alga Alaria angusta and protolinckiosides A (PL1), B (PL2), and linckoside L1 (L1) of th ...
DOI:
10.3390/md19100540

85. Comparative study of young shoots and the mature red headed cabbage as antioxidant food resources with antiproliferative effect on prostate cancer cells

Author:
Mariola Drozdowska; Teresa Leszczyńska; Aneta Koronowicz; Ewelina Piasna-Słupecka; Kinga Dziadek
Source:
RSC advances 2020 v.10 no.70 pp. 43021-43034
ISSN:
2046-2069
Subject:
antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; cabbage; carotenoids; cell lines; comparative study; diet-related diseases; flavonoids; food plants; ingredients; juices; knowledge; neoplasm cells; phenolic acids; polyphenols; prostatic neoplasms; sampling; shoots
Abstract:
... The increasing knowledge on health benefit properties of plant origin food ingredients supports recommendations for the use of edible plants in the prevention of diet related diseases, including cancer. The beneficial effects of young shoots of red cabbage can be attributed to their mixture of phytochemicals possessing antioxidant and potential anticancer activity. The objective of this study was ...
DOI:
10.1039/d0ra07861a

86. Culture-Dependent Microbiome of the Ciona intestinalis Tunic: Isolation, Bioactivity Profiling and Untargeted Metabolomics

Author:
Caroline Utermann; Vivien A. Echelmeyer; Martina Blümel; Deniz Tasdemir
Source:
Microorganisms 2020 v.8 no.11 pp. -
ISSN:
2076-2607
Subject:
Ciona intestinalis; animal pathogenic bacteria; antineoplastic activity; bacterial communities; cell lines; extracts; fungi; metabolites; metabolomics; microbiome; neoplasm cells; sampling; seawater; strains
Abstract:
... Ascidians and their associated microbiota are prolific producers of bioactive marine natural products. Recent culture-independent studies have revealed that the tunic of the solitary ascidian Cionaintestinalis (sea vase) is colonized by a diverse bacterial community, however, the biotechnological potential of this community has remained largely unexplored. In this study, we aimed at isolating the ...
DOI:
10.3390/microorganisms8111732

87. Cyperus rotundus L. alkaloid extracts enhance oncolytic Newcastle disease virus against digestive system neoplasms

Author:
Ahmed Majeed Al-Shammari; Russell A. Abo-Altemen; Muayd S. Shawkat
Source:
South African journal of botany 2021 v.143 pp. 266-273
ISSN:
0254-6299
Subject:
Avian orthoavulavirus 1; Cyperus rotundus; alkaloids; antagonism; antineoplastic activity; cancer therapy; cell lines; cytotoxicity; esophageal neoplasms; fibroblasts; gastrointestinal system; hepatoma; humans; neoplasm cells; new combination; rats; secondary metabolites; synergism; viability assays
Abstract:
... Digestive system cancers are common primary cancer in humans. Plants are an excellent source of compounds used in the treatment of different types of cancer. Virotherapy is a promising tool for fighting cancer because of its safety and selectivity. Thus, the present study proposed a new combination therapy consisting of secondary metabolite compounds (alkaloids) extracted from Cyperus rotundus L. ...
DOI:
10.1016/j.sajb.2021.08.002

88. Cytotoxic Activity of Selected Nigerian Medicinal Plants

Author:
Adetunji Joseph Aladesanmi; Funmilayo Gladys Famuyiwa; Ayodeji Oluwabunmi Oriola; Samuel Ayoolu Oguntimehin; Priscilla Oluwakemi Aiyedun; Gilbert Arthur
Source:
Journal of herbs, spices & medicinal plants 2020 v.26 no.2 pp. 203-217
ISSN:
1540-3580
Subject:
Artocarpus altilis; Cassia sieberiana; Eugenia uniflora; Hibiscus rosa-sinensis; Laportea; Trichilia; Xylopia aethiopica; aerial parts; antineoplastic activity; bark; breast neoplasms; breasts; cell lines; cell viability; cytotoxicity; flowers; fruits; humans; leaves; neoplasm cells; petroleum
Abstract:
... The study investigated eight Nigerian medicinal plants: Artocarpus communis fruit (Ac-F), Cassia sieberiana root bark (Cs-R), Eugenia uniflora leaf (Eu-L), Hibiscus rosa-sinensis flower (Hr-F), Laportea aestuans aerial part (La-A), Massularia acuminata stem bark (Ma-S), Trichilia heudelotii leaf (Th-L), and Xylopia aethiopica fruit (Xa-F), for anticancer activity. The alcoholic extracts of the pla ...
DOI:
10.1080/10496475.2019.1706214

89. Cytotoxicity and Antiproliferation of Phycocyanin from Spirulina platensis Extract on WiDr Colon Cancer Cell Line

Author:
Ajeng Kurniasari Putri; Safira Chairani Dimarti; Renni Yuniati; Neni Susilaningsih
Source:
Biosaintifika 2020 v.12 no.1 pp. 42-49
ISSN:
2338-7610
Subject:
Arthrospira platensis; antineoplastic activity; antineoplastic agents; cell lines; colorectal neoplasms; cytotoxicity; freshwater; inhibitory concentration 50; neoplasm cells; phycocyanin
Abstract:
... Phycocyanin from Spirulina platensis extract has anticancer activity against various types of cancer cell cultures. However study about its effect on colon cancer cell lines, especially the WiDr, has not been reported before. This study aimed to reveal the anticancer activity of phycocyanin from Spirulina platensis extract on WiDr cells. The research was an in vitro experimental study, with the in ...
DOI:
10.15294/biosaintifika.v12i1.22881

90. Determination of the antioxidant, antimicrobial and anticancer properties of the honey phenolic extract of five different regions of Bingöl province

Author:
Bülent Kaya; Adem Yıldırım
Source:
Journal of food science and technology 2021 v.58 no.6 pp. 2420-2430
ISSN:
0022-1155
Subject:
antineoplastic activity; caffeic acid; catechin; cell lines; chlorogenic acid; chrysin; ferulic acid; food additives; functional foods; gallic acid; honey; lycopene; p-coumaric acid; quercetin; syringes; technology; yeasts
Abstract:
... Bingol is a famous region for honey in Turkey. The amount of phenolic substance is also considered important for the anticancer, antioxidant and antimicrobial properties of honey. Anticancer activity of honey extract was determined as the most effective dose of 1 mg/mL using the WST1 anti-proliferation kit in the PC-3 cell line. Total phenol content were found between 476.09 ± 1.67 and 865.22 ± 3. ...
DOI:
10.1007/s13197-020-04783-x

91. Determination toxic effects of Hystrix Brachyura Bezoar extracts using cancer cell lines and embryo zebrafish (Danio rerio) models and identification of active principles through GC-MS analysis

Author:
Al’aina Yuhainis Firus Khan; Qamar Uddin Ahmed; Tanzina Sharmin Nippun; Ayah Hilles; Tara K. Jalal; Lay Kek Teh; Mohd Zaki Salleh; Suzita Mohd Noor; Azman Seeni; Alfi Khatib; Ridhwan Abdul Wahab
Source:
Journal of ethnopharmacology 2020 v.262 pp. 113138
ISSN:
0378-8741
Subject:
Danio rerio; antineoplastic activity; antineoplastic agents; blood circulation; brain; cardiovascular system; cell lines; edema; embryo (animal); gas chromatography-mass spectrometry; hatching; inhibitory concentration 50; lethal concentration 50; median effective concentration; models; neoplasm cells; neoplasms; tail; teratogenicity; traditional medicine; Malaysia
Abstract:
... Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments.This study was aimed to reveal three different PBs’ aqueous extracts(viz. PB-A, PB-B, PB-C) che ...
DOI:
10.1016/j.jep.2020.113138

92. Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

Author:
Se-Eun LEE; Zhanna OKHLOPKOVA; Chiyeon LIM; Suin CHO
Source:
Chinese journal of natural medicines 2020 v.18 no.10 pp. 793-800
ISSN:
1875-5364
Subject:
B-cell lymphoma; Dracocephalum; Russia; Western blotting; adenosine diphosphate; antineoplastic activity; antioxidant activity; apoptosis; caspase-8; cell cycle checkpoints; cell lines; cell proliferation; drug therapy; ethyl acetate; flavonoids; humans; leaves; medicinal plants; neoplasm cells; nomadic people; prostatic neoplasms; reactive oxygen species; research; ribose; superoxide dismutase
Abstract:
... Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia; however, research on this plant is currently limited. Recently, although studies have been conducted on the constituents of this plant and their antioxidant effects, data on its various pharmacological activities are still lacking. Thus, this study examined the anticancer potential of the dr ...
DOI:
10.1016/S1875-5364(20)60019-X

93. Eco-friendly extraction of Mastocarpus stellatus carrageenan for the synthesis of gold nanoparticles with improved biological activity

Author:
N. González-Ballesteros; M.D. Torres; N. Flórez-Fernández; L. Diego-González; R. Simón-Vázquez; M.C. Rodríguez-Argüelles; H. Domínguez
Source:
International journal of biological macromolecules 2021 v.183 pp. 1436-1449
ISSN:
0141-8130
Subject:
Mastocarpus stellatus; X-ray diffraction; antineoplastic activity; antioxidant activity; apoptosis; carrageenan; cell lines; cytotoxicity; endothelial cells; energy-dispersive X-ray analysis; lungs; monocytes; nanogold; oxidative stress; temperature; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... Carrageenan was extracted from Mastocarpus stellatus using hot water extraction under atmospheric and pressurized conditions. The influence of heating temperature during a non-isothermal heating profile up to temperatures in the range 70–190 °C was studied to evaluate the extraction yields and properties of the carrageenan fraction. Under the selected conditions (130 °C), extracted carrageenan (CM ...
DOI:
10.1016/j.ijbiomac.2021.05.115

94. Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells

Author:
Truong Thi Bich Ngoc; Nguyen Thi Hoai Nga; Nguyen Thi My Trinh; Tran Linh Thuoc; Dang Thi Phuong Thao
Source:
Journal of ethnopharmacology 2020 v.263 pp. 113222
ISSN:
0378-8741
Subject:
Elephantopus; antineoplastic activity; apoptosis; breast neoplasms; carcinoma; caspase-3; cell growth; cell lines; cell structures; colorectal neoplasms; cytotoxicity; ethyl acetate; gene expression; gene expression regulation; genes; human diseases; inhibitory concentration 50; liver; lung neoplasms; messenger RNA; myeloid leukemia; neoplasm cells; petroleum; proliferating cell nuclear antigen; signal transduction; traditional medicine; Vietnam
Abstract:
... Elephantopus mollis Kunth (EM), which belongs to Asteraceae family, has been used as a folk medicine with diverse therapeutic properties. Previous studies reported that crude extracts of this plant could inhibit several cancer cell lines, including breast carcinoma MCF-7, liver carcinoma HepG2, colorectal carcinoma DLD-1, lung carcinoma NCI–H23, etc.In this study, the anticancer activity and assoc ...
DOI:
10.1016/j.jep.2020.113222

95. Enhancement of interferon gamma stability as an anticancer therapeutic protein against hepatocellular carcinoma upon interaction with calycosin

Author:
Huiyu Yang; Suliman Khan; Aimin Sun; Qian Bai; Haowei Cheng; Keivan Akhtari
Source:
International journal of biological macromolecules 2021 v.185 pp. 813-820
ISSN:
0141-8130
Subject:
active ingredients; antineoplastic activity; cancer therapy; cell lines; fluorescence; hepatoma; interferon-gamma; temperature; ultraviolet-visible spectroscopy
Abstract:
... The stability of IFN-γ as a therapeutic protein can play a key role on its anticancer effects. Herein, we explored the thermodynamic parameters and conformational stability of IFN-γ in the presence of calycosin, the main active compound of Radix astragali, by different biophysical and theoretical analysis. Afterwards, the improved anticancer effects of IFN-γ-calycosin interaction relative to IFN-γ ...
DOI:
10.1016/j.ijbiomac.2021.06.159

96. Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide

Author:
Federica Sodano; Robert J. Cavanagh; Amanda K. Pearce; Loretta Lazzarato; Barbara Rolando; Aurore Fraix; Thais F. Abelha; Catherine E. Vasey; Cameron Alexander; Vincenzo Taresco; Salvatore Sortino
Source:
Biomaterials science 2020 v.8 no.5 pp. 1329-1344
ISSN:
2047-4849
Subject:
antineoplastic activity; cell lines; cytotoxicity; doxorubicin; drug carriers; drug therapy; fluorescence; intestines; lungs; nanoparticles; neoplasm cells; nitric oxide; nitrogen; oxygen; photochemistry; polymers; skin (animal); skin neoplasms; solvents; urea
Abstract:
... Combinations of conventional chemotherapeutics with unconventional anticancer agents such as reactive oxygen and nitrogen species may offer treatment benefits for cancer therapies. Here we report a novel polymeric platform combining the delivery of Doxorubicin (DOXO) with the light-regulated release of nitric oxide (NO). An amphiphilic block-copolymer (P1) was designed and synthesized as the drug ...
DOI:
10.1039/c9bm01644a

97. Essential oil extracted from leaf of Phoebe bournei (Hemsl.) yang: chemical constituents, antitumor, antibacterial, hypoglycemic activities

Author:
Wen Ding; Ning Liping; Huizi Xing; Zhiting Wei; Qian Zhoua; Ruihong Nong; Jianquan Chen
Source:
Natural product research 2020 v.34 no.17 pp. 2524-2527
ISSN:
1478-6427
Subject:
Epidermophyton floccosum; Microsporum gypseum; Phoebe bournei; adipocytes; antineoplastic activity; bacteria; breasts; cell lines; chemical composition; colorectal neoplasms; essential oils; gas chromatography-mass spectrometry; glucose; glycemic effect; hot water treatment; leaves; leukemia; neoplasm cells; oils
Abstract:
... The essential oil were extracted from the leaf of Phoebe bournei (Hemsl.) Yang by a hydrothermal method and then analyzed by gas chromatography–mass spectrometry. The leaf oil mainly included α-copaene (5.44%), α-muurolene (7.32%), δ-cadinene (11.44%), 1s-calamenene (5.18%). Phoebe bournei (Hemsl.) Yang leaf essential oil had significant inhibitory activity against Epidermophyton floccosum and Mic ...
DOI:
10.1080/14786419.2018.1542393

98. Estimation of apoptosis-inducing compounds present in Gomphrena globose L. by molecular docking

Author:
Rachinnth Ravichandran; Akash Lashmanasamy; Akash Vinayagam; Aneesh Nair; Florida Tilton
Source:
Journal of BioScience and Biotechnology 2021 v.10 no.1 pp. 1-8
ISSN:
1314-6246
Subject:
DNA; DNA fragmentation; Gomphrena globosa; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; biotechnology; breast neoplasms; cell lines; cell proliferation; chloroform; cytotoxicity; energy; ethanol; flowers; glycosides; leaves; mechanism of action; neoplasm cells; oleuropein; phytochemicals; pro-apoptotic proteins
Abstract:
... Gomphrena globosa, is a species of the family Amaranthaceae which possess several bioactive compounds that have shown considerable anti-cancer properties. This study aims to identify the compounds responsible for the cytotoxic activity and assess the mechanism of action, especially concerning the induction of apoptosis by interaction with anti-apoptotic proteins. Extracts were prepared for the flo ...

99. Exploring anticancer activity of wild and polyploid mutant of Artemisia cina

Author:
Sri Kasmiyati; Elizabeth Betty Elok Kristiani; Maria Marina Herawati; Ferdy S Rondonuwu
Source:
Biodiversitas 2021 v.22 no.3 pp. -
ISSN:
2085-4722
Subject:
Artemisia; antineoplastic activity; artemisinin; cell lines; colchicine; colorectal neoplasms; cytotoxicity; doxorubicin; hexane; inhibitory concentration 50; lung neoplasms; mutants; neoplasm cells; polyploidy; probit analysis; quercetin; rutin; Indonesia
Abstract:
... Kasmiyati S, Kristiani EBE, Herawati MM, Rondonuwu FS. 2021. Exploring anticancer activity of wild and polyploid mutant of Artemisia cina. Biodiversitas 22: 1227-1234. The research aims were to explore the anticancer compounds in wild type (W) and polyploid mutant (P) of Artemisia cina Berg ex Poljakov using NIR and compare their cytotoxicity and selectivity on WiDR colon cancer and HTB183 lung ca ...
DOI:
10.13057/biodiv/d220319

100. Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species

Author:
Tien T. Dang; Lai Y. Chan; Yen-Hua Huang; Linh T. T. Nguyen; Quentin Kaas; Tien Huynh; David J. Craik
Source:
Journal of natural products 2020 v.83 no.6 pp. 1817-1828
ISSN:
1520-6025
Subject:
Viola; antineoplastic activity; asthma; cell lines; cytotoxicity; human diseases; humans; medicinal plants; mountains; neoplasm cells; oxygen; prostatic neoplasms; sequence diversity; uterine cervical neoplasms; Vietnam
Abstract:
... Viola is the largest genus in the Violaceae plant family and is known for its ubiquitous natural production of cyclotides. Many Viola species are used as medicinal herbs across Asia and are often consumed by humans in teas for the treatment of diseases, including ulcers and asthma. Previous studies reported the isolation of cyclotides from Viola species in many countries in the hope of discovering ...
DOI:
10.1021/acs.jnatprod.9b01218