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You searched for: Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity Subject term cytotoxicity Remove constraint Subject term: cytotoxicity
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1. (+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks

Author:
Chen Wei-Lun; Ren Yulin; Ren Jinhong; Erxleben Christian; Johnson Michael E.; Gentile Saverio; Kinghorn A. Douglas; Swanson Steven M.; Burdette Joanna E.
Source:
Journal of natural products 2017 v.80 no.3 pp. 659-669
ISSN:
1520-6025
Subject:
Streblus asper; adverse effects; anticarcinogenic activity; antineoplastic activity; antineoplastic agents; apoptosis; bark; cytotoxicity; digitoxin; digoxin; humans; in vitro studies; interphase; mitogen-activated protein kinase; molecular models; mutants; neoplasm cells; ouabain; ovarian neoplasms; transcription factor NF-kappa B; Vietnam
Abstract:
... (+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using an in vitro assay and molecular docking analysis indicated that (+)-strebloside binds and inhibits Na⁺/K⁺-ATPase in a similar manner to digitoxin. Inhibition of growth of different high-grad ...
DOI:
10.1021/acs.jnatprod.6b01150
PubMed:
28234008
PubMed Central:
PMC5768141

2. (3,3’-Methylene)bis-2-hydroxy-1,4-naphthoquinones induce cytotoxicity against DU145 and PC3 cancer cells by inhibiting cell viability and promoting cell cycle arrest

Author:
Paula Priscilla de Freitas; Ruan Carlos Busquet Ribeiro; Isabella dos Santos Guimarães; Caroline S. Moreira; David R. Rocha; Fernando de Carvalho da Silva; Vitor Francisco Ferreira; Etel Rodrigues Pereira Gimba
Source:
Molecular biology reports 2021 v.48 no.4 pp. 3253-3263
ISSN:
0301-4851
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; cell viability; cytotoxicity; drug resistance; drug therapy; flow cytometry; metastasis; molecular biology; prostatic neoplasms
Abstract:
... We developed a novel method for the synthesis of bis-naphthoquinones (BNQ), which are hybrids of lawsone (2-hydroxy-1,4-naphthoquinone) and 3-hydroxy-juglone (3,5-dihydroxy-1,4-naphthoquinone). The anticancer activity of three synthesized compounds, named 4 (RC10), 5 (RCDFC), and 6 (RCDOH) was evaluated in vitro against two metastatic prostate cancer (PCa) cell lines, DU145 and PC3, using MTT assa ...
DOI:
10.1007/s11033-021-06406-w

3. (−)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

Author:
Suzuki Yuki; Saito Yohei; Goto Masuo; Newman David J.; O’Keefe Barry R.; Lee Kuo-Hsiung; Nakagawa-Goto Kyoko
Source:
Journal of natural products 2017 v.80 no.1 pp. 220-224
ISSN:
1520-6025
Subject:
Cryptocarya; DNA damage; alkaloids; antineoplastic activity; bark; cytotoxicity; fractionation; humans; inhibitory concentration 50; mechanism of action; multiple drug resistance; neoplasm cells
Abstract:
... Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH₂Cl₂ extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a multidrug-resistant subline. Since more common 2,3,8,9-t ...
DOI:
10.1021/acs.jnatprod.6b01153
PubMed:
28099003
PubMed Central:
PMC5516478

4. 1,2,3,4,6-Pentakis[-O-(3,4,5-trihydroxybenzoyl)]-α,β-D-glucopyranose (PGG) analogs: design, synthesis, anti-tumor and anti-oxidant activities

Author:
Qurat-ul-ain Shaikh; Meiting Yang; Khadim Hussain Memon; Mehreen Lateef; Du Na; Shengbiao Wan; Deslandes Eric; Lijuan Zhang; Tao Jiang
Source:
Carbohydrate research 2016 v.430 pp. 72-81
ISSN:
0008-6215
Subject:
antineoplastic activity; antioxidant activity; antioxidants; benzoic acid; cinnamic acid; colon; cytotoxicity; drug therapy; humans; hydrogenation; inhibitory concentration 50; neoplasms
Abstract:
... 1,2,3,4,6-Pentakis[-O-(3,4,5-trihydroxybenzoyl)]-α,β-D-glucopyranose (PGG) 12 has been reported for its antioxidant activities, where the free OH groups in PGG seem to be critical for activities. To explore PGG-based compounds as chemotherapeutic agents and to analyze the contribution of specific OH groups in PGG for anti-cancer activities, we designed and synthesized a series of 27 benzoic and ci ...
DOI:
10.1016/j.carres.2016.04.021

5. 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity against Oral Cancer Cells through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts

Author:
Yi-Chang Liu; Bo-Rong Peng; Kai-Cheng Hsu; Mohamed El-Shazly; Shou-Ping Shih; Tony Eight Lin; Fu-Wen Kuo; Yi-Cheng Chou; Hung-Yu Lin; Mei-Chin Lu
Source:
Marine drugs 2020 v.18 no.8 pp. -
ISSN:
1660-3397
Subject:
DNA; Western blotting; acetylcysteine; animal models; antineoplastic activity; antineoplastic agents; antioxidant enzymes; apoptosis; cell viability; corals; cytotoxicity; enzyme activity; flow cytometry; fluorescent antibody technique; immunostimulants; mechanism of action; membrane potential; mitochondrial membrane; mouth neoplasms; neoplasm cells; precipitin tests; proteins; reactive oxygen species; small interfering RNA; toxicity testing; transfection; xenotransplantation
Abstract:
... 13-Acetoxysarcocrassolide (13-AC), a marine cytotoxic product isolated from the alcyonacean coral Lobophytum crassum, exhibited potent antitumor and immunostimulant effects as reported in previous studies. However, the 13-AC antitumor mechanism of action against oral cancer cells remains unclear. The activity of 13-AC against Ca9-22 cancer cells was determined using MTT assay, flow cytometric anal ...
DOI:
10.3390/md18080382

6. 17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells

Author:
Xu Ya-ming; Bunting Daniel P.; Liu Manping X.; Bandaranayake Hema A.; Gunatilaka A. A. Leslie
Source:
Journal of natural products 2016 v.79 no.4 pp. 821-830
ISSN:
1520-6025
Subject:
Physalis; adenocarcinoma; aeroponics; antineoplastic activity; breasts; cytotoxicity; lung neoplasms; neoplasm cells; prostatic neoplasms; spectral analysis; spectroscopy; structure-activity relationships
Abstract:
... When cultivated under aeroponic growth conditions, Physalis crassifolia produced 11 new withanolides (1–11) and seven known withanolides (12–18) including those obtained from the wild-crafted plant. The structures of the new withanolides were elucidated by the application of spectroscopic techniques, and the known withanolides were identified by comparison of their spectroscopic data with those re ...
DOI:
10.1021/acs.jnatprod.5b00911

7. 18-Des-hydroxy Cytochalasin: an antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler

Author:
Elson Rudimar Brissow; Igor Pereira da Silva; Kátia Aparecida de Siqueira; Jaqueline Alves Senabio; Leticia Pereira Pimenta; Ana Helena Januário; Lizandra Guidi Magalhães; Ricardo Andrade Furtado; Denise Crispim Tavares; Policarpo Ademar Sales Junior; Jane Lima Santos; Marcos Antônio Soares
Source:
Parasitology research 2017 v.116 no.7 pp. 1823-1830
ISSN:
0932-0113
Subject:
Combretum; Diaporthe; Leishmania; Schistosoma mansoni; Trypanosoma cruzi; adults; amastigotes; antineoplastic activity; antioxidant activity; antiparasitic agents; breast neoplasms; cytotoxicity; endophytes; ethyl acetate; fibroblasts; fungi; humans; inhibitory concentration 50; neoplasm cells; promastigotes; roots; trypomastigotes; viability
Abstract:
... Chemical investigation of the ethyl acetate extract from the endophytic fungus Diaporthe phaseolorum-92C (92C) isolated from the roots of Combretum lanceolatum led to the isolation of 18-des-hydroxy Cytochalasin H (compound 1). The trypanocidal and schistosomicidal activity and cytotoxicity of the extract from 92C were evaluated. The schistosomicidal, leishmanicidal, antimicrobial, and antioxidant ...
DOI:
10.1007/s00436-017-5451-9

8. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

9. 2-(3′,4′-Dimethoxybenzylidene)tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species

Author:
Yashveer Gautam; Sonam Dwivedi; Ankita Srivastava; Hamidullah; Arjun Singh; D. Chanda; Jyotsna Singh; Smita Rai; Rituraj Konwar; Arvind S. Negi
Source:
RSC advances 2016 v.6 no.40 pp. 33369-33379
ISSN:
2046-2069
Subject:
acetylcysteine; acute oral toxicity; adverse effects; antineoplastic activity; apoptosis; breast neoplasms; cell lines; cytotoxicity; inhibitory concentration 50; interphase; mammary neoplasms (animal); microtubules; mitosis; models; mortality; neoplasm cells; polymerization; rats; reactive oxygen species; tubulin; women
Abstract:
... Breast cancer is a leading cause of women mortality worldwide. Diverse analogues of 2-benzylidene tetralone have been synthesized and evaluated for anti-cancer activity against a panel of cancer cell lines. Among these, compounds 13, 15 and 19 exhibited potent anti-cancer activity (IC₅₀ = 1–3 μM) against human breast cancer cells, MDA-MB-231 and non-toxic towards non-malignant cell line, HEK-293. ...
DOI:
10.1039/c6ra02663j

10. 2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model

Author:
Yu Heng-Yi; Zhang Xiao-Qiong; Li Xue-; Zeng Fan-Bo; Ruan Han-Li
Source:
Journal of natural products 2013 v.76 no.5 pp. 889-895
ISSN:
1520-6025
Subject:
Juglans; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; bark; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; dose response; flow cytometry; hepatoma; human cell lines; humans; in vivo studies; interphase; mice; mitochondria; models; neoplasm cells; propidium; proteins; shrinkage; staining
Abstract:
... In order to discover anticancer agents from natural sources, an ethanol-soluble extract of the root bark of Juglans cathayensis was investigated and showed cytotoxic effects against various human cancer cell lines. A subsequent phytochemical study on the EtOAc-soluble fraction determined 2-methoxyjuglone (1) as one of the main active constituents. Compound 1 was shown to be cytotoxic against HepG2 ...
DOI:
10.1021/np400025b

11. 2-Substituted thiazole-4-carboxamide derivatives as tiazofurin mimics: synthesis and in vitro antitumour activity

Author:
Mirjana Popsavin; Vesna Kojić; Saša Spaić; Miloš Svirčev; Gordana Bogdanović; Dimitar Jakimov; Lidija Aleksić; Velimir Popsavin
Source:
Tetrahedron 2014 v.70 pp. 2343-2350
ISSN:
0040-4020
Subject:
Western blotting; antineoplastic activity; apoptosis; arabinose; caspase-3; cell cycle; chemical reactions; chemical structure; cytotoxicity; flow cytometry; humans; neoplasm cells; organic compounds; xylose
Abstract:
... Tiazofurin analogues bearing a 5-hydroxymethyl-2-methyl-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol moiety as a sugar mimic (2 and 3), and two novel thiazole-based acyclo-C-nucleosides 4 and 16 have been synthesized in multistep sequences starting from d-xylose (compounds 2 and 3) or from d-arabinose (compounds 4 and 16). All synthesized analogues showed potent in vitro antitumour activities against a p ...
DOI:
10.1016/j.tet.2014.02.035

12. 2α-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action

Author:
Mohamed-Elamir F. Hegazy; Mona Dawood; Nuha Mahmoud; Mohamed Elbadawi; Yoshikazu Sugimoto; Sabine M. Klauck; Nagla Mohamed; Thomas Efferth
Source:
Phytomedicine 2021 v.81 pp. 153409
ISSN:
0944-7113
Subject:
DNA damage; P-glycoproteins; Pulicaria undulata; antineoplastic activity; apoptosis; cell cycle checkpoints; cytotoxicity; epidermal growth factor receptors; gene expression regulation; gene overexpression; human cell lines; leukemia; mechanism of action; medicinal plants; messenger RNA; microarray technology; multiple drug resistance; neoplasm cells; phosphatidylinositol 3-kinase; sesquiterpenoid lactones; transcriptome; transcriptomics
Abstract:
... Sesquiterpene lactones having α-methylene-γ-lactone moiety are promising natural metabolites showing various biological activity. One of the major metabolites isolated from Pulicaria undulata, 2α-hydroxyalantolactone (PU-1), has not been investigated in detail yet. Multidrug resistance (MDR) represents a major obstacle for cancer chemotherapy and the capability of novel natural products to overcom ...
DOI:
10.1016/j.phymed.2020.153409

13. 2α-Hydroxyursolic Acid Inhibited Cell Proliferation and Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells through the p38/MAPK Signal Transduction Pathway

Author:
Xue Jiang; Tong Li; Rui Hai Liu
Source:
Journal of agricultural and food chemistry 2016 v.64 no.8 pp. 1806-1816
ISSN:
0021-8561
Subject:
Western blotting; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; cell proliferation; cyclins; cytotoxicity; humans; mechanism of action; methylene blue; mitogen-activated protein kinase; neoplasm cells; proliferating cell nuclear antigen; signal transduction
Abstract:
... The mechanisms of action of 2α-hydroxyursolic acid in inhibiting cell proliferation and inducing apoptosis in MDA-MB-231 human breast cancer cells were investigated. The antiproliferative activity and cytotoxicity were determined by the methylene blue assay. The expression of proteins was determined using Western blot. 2α-Hydroxyursolic acid significantly inhibited MDA-MB-231 cell proliferation, a ...
DOI:
10.1021/acs.jafc.5b04852

14. 4-Aminoantipyrine in carbohydrate research: Design, synthesis and anticancer activity of thioglycosides of a novel class of 4-aminoantipyrines and their corresponding pyrazolopyrimidine and pyrazolopyridine thioglycosides

Author:
Galal H. Elgemeie; Mamdouh A. Abu-Zaied; Samah A. Loutfy
Source:
Tetrahedron 2017 pp. -
ISSN:
0040-4020
Subject:
antineoplastic activity; antipyrine; breasts; chemical reactions; chemical structure; colon; colorectal neoplasms; cytotoxicity; humans; liver; liver neoplasms; neoplasm cells; nuclear magnetic resonance spectroscopy; sodium; spectral analysis
Abstract:
... A convenient method for the synthesis of antipyrine, pyrazolopyrimidine and pyrazolopyridine thioglycosides was developed. This study reports a novel and efficient method for the synthesis of thioglycosides of a novel class of 4-aminoantipyrines 6a,b; 13a,b and their corresponding pyrazolopyrimidine thioglycosides 7a,b; 9a,b and pyrazolopyridine thioglycosides 14a,b; 16a,b. These series of compoun ...
DOI:
10.1016/j.tet.2017.08.024

15. 4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line

Author:
Polyana Lopes Benfica; Renato Ivan de Ávila; Bruna dos Santos Rodrigues; Alane Pereira Cortez; Aline Carvalho Batista; Marilisa Pedroso Nogueira Gaeti; Eliana Martins Lima; Kênnia Rocha Rezende; Marize Campos Valadares
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1899-1908
ISSN:
1744-5116
Subject:
acetylcysteine; antineoplastic activity; apoptosis; caspases; cell lines; cyclins; cytochrome c; cytotoxicity; drug therapy; enzyme activity; inhibitory concentration 50; interphase; lymphocytes; mitochondria; neoplasms; phosphatidylserines; reactive oxygen species
Abstract:
... Context: 4-Nerolidylcatechol (4-NRC) has showed antitumor potential through apoptosis. However, its apoptotic mechanisms are still unclear, especially in leukemic cells. Objectives: To evaluate the cytotoxic potential of 4-NRC and its cell death pathways in p53-null K562 leukemic cells. Materials and methods: Cytotoxicity of 4-NRC (4.17–534.5 μM) over 24 h of exposure was evaluated by MTT assay. 4 ...
DOI:
10.1080/13880209.2017.1311351
PubMed:
28644062
PubMed Central:
PMC6130688

16. 5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

Author:
Xin-Xin Zhao; Juan-Juan Chang; Qi-Lin Wang; Rong Lu; Ling-Jun Li; Xiao Sun; Wei-Dong Xie; Xia Li
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1079-1090
ISSN:
1477-2213
Subject:
4',6-diamidino-2-phenylindole; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; cyclins; cytochrome c; cytotoxicity; flavonoids; flow cytometry; hepatoma; humans; mitochondria; neoplasm cells; phosphorylation; staining; structure-activity relationships
Abstract:
... 5,6-Dihydroxy-3,7,4′-trimethoxyflavonol (AH5), 5,6,3′-trihydroxy-3,7,4′-trimethoxyflavonol (AH22), artemetin, and oroxylin A are four flavonoids with the same 2-phenyl-chromone skeleton isolated from the Chinese herb Aster himalaicus . The aim of this study was to evaluate the structure–activity relationship of these four analogs and the mediation of AH5 cytotoxicity via G2/M arrest and apoptosis ...
DOI:
10.1080/10286020.2016.1191473

17. 5-Fluorouracil monodispersed chitosan microspheres: Microfluidic chip fabrication with crosslinking, characterization, drug release and anticancer activity

Author:
Tianxi He; Wenbin Wang; Benshou Chen; Jiu Wang; Qionglin Liang; Boshui Chen
Source:
Carbohydrate polymers 2020 v.236 pp. 116094
ISSN:
0144-8617
Subject:
antineoplastic activity; chitosan; crosslinking; cytotoxicity; encapsulation; fluorouracil; glutaraldehyde; microparticles; models; neoplasm cells; organ-on-a-chip; tripolyphosphates
Abstract:
... Different size and morphology monodispersed chitosan (CS) microspheres loaded with the anticancer drug of 5-fluorouracil (5-Fu) were prepared by the microfluidic method assisted by a crosslinking unit with crosslinkers of tripolyphosphate (TPP) and glutaraldehyde (GTA). The sizes, morphologies, drug loading, encapsulation efficiency, drug release and cytotoxicity of 5-Fu loaded CS microspheres wer ...
DOI:
10.1016/j.carbpol.2020.116094

18. 5-Fluorouracil-loaded β-cyclodextrin-carrying polymeric poly(methylmethacrylate)-coated samarium ferrite nanoparticles and their anticancer activity

Author:
M. S. Hariharan; R. Sivaraj; S. Ponsubha; R. Jagadeesh; I. V. M. V. Enoch
Source:
Journal of materials science 2019 v.54 no.6 pp. 4942-4951
ISSN:
0022-2461
Subject:
antineoplastic activity; beta-cyclodextrin; cytotoxicity; energy-dispersive X-ray analysis; ferrimagnetic materials; fluorouracil; magnetic fields; magnetic properties; nanocarriers; nanoparticles; neoplasms; polymers; samarium; spectroscopy
Abstract:
... Drug-loading on magnetic nanoparticles coated with biocompatible polymers are intriguing nanostructures for targeted delivery of anticancer drugs with the application of a magnetic field. In this paper, we report the preparation of SmFeO₃ nanoparticles and loading of the anticancer drug 5-fluorouracil on the carrier by forming host–guest complex with β-cyclodextrin. The material and the polymer ar ...
DOI:
10.1007/s10853-018-3161-z

19. 6-(1-Alkenoyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives: Synthesis and evaluation of antitumor activity

Author:
Young-Jae You; Byung-Zun Ahn
Source:
Archives of pharmacal research 1998 v.21 no.6 pp. 738
ISSN:
0253-6269
Subject:
antineoplastic activity; cytotoxicity; mice; naphthoquinones
Abstract:
... Thirty six 5,8-dimethoxy-1,4-naphthoquinone derivatives, which bear unsaturated alkyl side chain with ester bond, were synthesized and tested cytotoxic activity on L1210 cells and antitumor activity against ICR mice bearing S-180 cells. It could be recognized that the cytotoxicities of naphthoquinones with R₁ being methyl and propyl (IV1∼24) were not enhanced by replacing the alkanoyls with alkeno ...
DOI:
10.1007/BF02976768

20. 6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes

Author:
Tomoya Kitakaze; Sihao Yuan; Masako Inoue; Yasukiyo Yoshioka; Yoko Yamashita; Hitoshi Ashida
Source:
Archives of biochemistry and biophysics 2020 v.686 pp. 108329
ISSN:
0003-9861
Subject:
Eutrema japonica; acetaldehyde; acetic acid; alcohol dehydrogenase; aldehyde dehydrogenase; antineoplastic activity; bioactive compounds; cytotoxicity; ethanol; hepatocytes; isothiocyanates; liver; metabolites; mice; mitochondria; oral administration; protein synthesis
Abstract:
... In the body, alcohol dehydrogenase rapidly converts ethanol to its toxic metabolite, acetaldehyde, which is further metabolized to non-toxic acetic acid by aldehyde dehydrogenase (ALDH). 6-(methylsulfinyl)hexyl isothiocyanate (6-MSITC), a major bioactive compound in Wasabi (Wasabia japonica) has various physiological effects such as anti-oxidative, anti-inflammatory and anti-cancer effects. Howeve ...
DOI:
10.1016/j.abb.2020.108329

21. 6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions

Author:
Marta Woźniak; Sebastian Makuch; Kinga Winograd; Jerzy Wiśniewski; Piotr Ziółkowski; Siddarth Agrawal
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 141
ISSN:
2662-7671
Subject:
Western blotting; anti-inflammatory activity; antineoplastic activity; apoptosis; autophagy; colorectal neoplasms; cytotoxicity; drug therapy; fluorouracil; ginger; glucose; hypoxia; metastasis; neoplasm cells; neoplasm progression; signal transduction; starvation
Abstract:
... BACKGROUND: The development and growth of colorectal cancer based on constitutive activation of numerous signaling pathways that stimulate proliferation and metastasis. Plant-derived agents excel by targeting multiple aspects of tumor progression. Previous investigations have shown that ginger derivatives- shogaols possess anti-cancer and anti-inflammatory effects. In the present study, we have ex ...
DOI:
10.1186/s12906-020-02913-8

22. 6‐Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest

Author:
Vaishali Kapoor; Sadhna Aggarwal; Satya N. Das
Source:
Phytotherapy research 2016 v.30 no.4 pp. 588-595
ISSN:
0951-418X
Subject:
additive effect; antineoplastic activity; apoptosis; caspase-3; cell cycle checkpoints; cell proliferation; chemiluminescence; chemoprevention; cisplatin; cytotoxicity; dose response; drug therapy; flow cytometry; functional foods; humans; inhibitory concentration 50; mechanism of action; neoplasm cells; propidium; tetrazolium; uterine cervical neoplasms; zwitterions
Abstract:
... 6‐Gingerol, a potent nutraceutical, has been shown to have antitumor activity in different tumors, although its mechanism of action is not well understood. In this study, we evaluated antitumor activities of 6‐gingerol on human oral (SCC4, KB) and cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin. Tumor cell proliferation was observed using 3‐(4,5‐dimethylthiaz ...
DOI:
10.1002/ptr.5561

23. 7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells

Author:
En-Xia Wang; Bo-Yang Zou; Lei Shi; Lin-Ying Du; Yan-Yan Zhu; Ya-Meng Jiang; Xiao-Dong Ma; Xiao-Hui Kang; Chang-Yuan Wang; Yu-Hong Zhen; Li-Dan Sun
Source:
Life sciences 2017 v.180 pp. 102-113
ISSN:
0024-3205
Subject:
4',6-diamidino-2-phenylindole; Western blotting; acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; caspases; cell cycle; chloroquine; cytotoxicity; fibroblasts; humans; lung neoplasms; neoplasm cells; proteins; quercetin; reactive oxygen species; small interfering RNA; staining; transmission electron microscopy; viability
Abstract:
... To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms.Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was determined wit ...
DOI:
10.1016/j.lfs.2017.05.008

24. A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

Author:
Mohamed Ali Seyed; Ibrahim Jantan; Syed Nasir Abbas Bukhari; Kavitha Vijayaraghaven
Source:
Journal of agricultural and food chemistry 2016 v.64 no.4 pp. 725-737
ISSN:
0021-8561
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; antioxidants; arrhythmia; atherosclerosis; cell growth; chemoprevention; curcumin; cytotoxicity; drug therapy; epigallocatechin; grapes; humans; hypercholesterolemia; inflammation; magnolol; mechanism of action; metabolites; morbidity; mortality; neoplasms; pleiotropy; polyphenols; resveratrol; vasodilation; wines
Abstract:
... Cancer is a diverse class of diseases characterized by uncontrolled cell growth that constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress, the treatment modalities of cancer are still insufficient. Several new concepts have emerged for therapeutic intervention in malignant diseases with the goal of identifying specific targets and overcoming resistance again ...
DOI:
10.1021/acs.jafc.5b05993

25. A Copper-Mediated Disulfiram-Loaded pH-Triggered PEG-Shedding TAT Peptide-Modified Lipid Nanocapsules for Use in Tumor Therapy

Author:
Zhang Ling; Tian Bin; Li Yi; Lei Tian; Meng Jia; Yang Liu; Zhang Yan; Chen Fen; Zhang Haotian; Xu Hui; Zhang Yu; Tang Xing
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.45 pp. 25147-25161
ISSN:
1944-8252
Subject:
antineoplastic activity; composite polymers; copper; cytotoxicity; disulfiram; fluorescent dyes; human cell lines; lipids; mice; nanocapsules; neoplasm cells; neoplasms; pH; pharmacokinetics; therapeutics
Abstract:
... Disulfiram, which exhibits marked tumor inhibition mediated by copper, was encapsulated in lipid nanocapsules modified with TAT peptide (TATp) and pH-triggered sheddable PEG to target cancer cells on the basis of tumor environmental specificity. PEG-shedding lipid nanocapsules (S-LNCs) were fabricated from LNCs by decorating short PEG chains with TATp (HS-PEG₁ₖ–TATp) to form TATp-LNCs and then cov ...
DOI:
10.1021/acsami.5b06488

26. A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

Author:
D. Montagner; B. Fresch; K. Browne; V. Gandin; A. Erxleben
Source:
Chemical communications 2016 v.53 no.1 pp. 134-137
ISSN:
1364-548X
Subject:
antineoplastic activity; cell lines; chemical reactions; computational methodology; copper; cytotoxicity; mice; models; multiple drug resistance; neoplasms
Abstract:
... A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr₂(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods. ...
DOI:
10.1039/c6cc08100b

27. A Dual Functional Nanoreactor for Synergistic Starvation and Photodynamic Therapy

Author:
Yang Zhu; Hongdong Shi; Tuanwei Li; Jianing Yu; Zhengxi Guo; Junjie Cheng; Yangzhong Liu
Source:
ACS applied materials & interfaces 2020 v.12 no.16 pp. 18309-18318
ISSN:
1944-8252
Subject:
animal models; antineoplastic activity; catalytic activity; cytotoxicity; enzyme therapy; gluconic acid; glucose; glucose oxidase; hydrogen peroxide; hydrophilicity; hydrophobicity; irradiation; manganese; nanoparticles; neoplasm cells; neoplasms; oxidation; photochemotherapy; photosensitizing agents; porous media; silica; singlet oxygen; starvation
Abstract:
... The combination of photodynamic therapy (PDT) and enzyme therapy is a highly desirable approach in malignant tumor therapies as it takes advantage of the spatial-controlled PDT and the effective enzyme-catalyzed bioreactions. However, it is a challenge to co-encapsulate hydrophilic enzymes and hydrophobic photosensitizers, and these two agents often interfere with each other. In this work, a proto ...
DOI:
10.1021/acsami.0c01039

28. A New Cytotoxic Brominated Acetylenic Hydrocarbon from the Marine Sponge Haliclona sp. with a Selective Effect against Human Breast Cancer

Author:
Walied M. Alarif; Ahmed Abdel-Lateff; Sultan S. Al-Lihaibi; Seif-Eldin N. Ayyad; Farid A. Badria
Source:
Zeitschrift für Naturforschung 2014 v.68 no.1-2 pp. 70-75
ISSN:
1865-7125
Subject:
Cercopithecus aethiops; Haliclona; antineoplastic activity; breast neoplasms; carcinoma; cytotoxicity; hepatoma; humans; inhibitory concentration 50; kidneys; metabolites; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; Red Sea
Abstract:
... Three acetylenic brominated derivatives were isolated from a Red Sea sponge, Haliclona sp. One of them, 18-bromooctadeca-9(E),17(E)-dien-7,15-diynoic acid (), is a known metabolite, and the other two are new compounds, (1E,5E,12E,19E)-1,22-dibromodocosa- 1,5,12,19-tetraen-3,14,21-triyne (1) and methyl 18-bromooctadeca-9(E),17(E)-dien-7,15- diynoate (2) which was isolated for the first time as a na ...
DOI:
10.1515/znc-2013-1-210

29. A New Water-Soluble Nanomicelle Formed through Self-Assembly of Pectin–Curcumin Conjugates: Preparation, Characterization, and Anticancer Activity Evaluation

Author:
Bai Feng; Diao Jiajing; Wang Ying; Sun Shixin; Zhang Hongmei; Liu Yunyun; Wang Yanqing; Cao Jian
Source:
Journal of agricultural and food chemistry 2017 v.65 no.32 pp. 6840-6847
ISSN:
1520-5118
Subject:
Curcuma longa; Fourier transform infrared spectroscopy; antineoplastic activity; antioxidant activity; aqueous solutions; bioavailability; breast neoplasms; curcumin; cytotoxicity; fluorescence emission spectroscopy; human cell lines; liver neoplasms; medicine; neoplasm cells; nuclear magnetic resonance spectroscopy; solubility; thermal properties; thermogravimetry; transmission electron microscopy; uterine cervical neoplasms
Abstract:
... Curcumin is a dominating active component of Curcuma longa and has been studied widely because of its prominent biological activities. The extremely low aqueous solubility, stability, and bioavailability of curcumin limit its application in the field of medicine. In this study, we developed pectin–curcumin (PEC–CCM) conjugates that could self-assemble water-soluble nanomicelles in aqueous solution ...
DOI:
10.1021/acs.jafc.7b02250

30. A PEGylated alternating copolymer with oxidation-sensitive phenylboronic ester pendants for anticancer drug delivery

Author:
Yu Zhang; Pan He; Xinming Liu; Huailin Yang; Hongyu Zhang; Chunsheng Xiao; Xuesi Chen
Source:
Biomaterials science 2019 v.7 no.9 pp. 3898-3905
ISSN:
2047-4849
Subject:
antineoplastic activity; aqueous solutions; cell viability; composite polymers; confocal laser scanning microscopy; copolymerization; cytotoxicity; doxorubicin; encapsulation; flow cytometry; hydrogen peroxide; hydrophobicity; mice; micelles; nanocarriers; nanoparticles; neoplasms; oxidation; oxidative stress; pH; phenylboronic acids; polyethylene glycol; tetrazolium
Abstract:
... To target a response to a high oxidative stress environment of inflammatory or tumor sites, various reactive oxygen species (ROS) sensitive polymers have been developed as drug delivery systems. In this study, a novel oxidation sensitive copolymer, phenylboronic acid pinacol ester-functionalized methoxyl poly(ethylene glycol)-block-poly(phthalic anhydride-alter-glycidyl propargyl ether) (mPEG-b-P( ...
DOI:
10.1039/c9bm00884e

31. A Redox Stimulation-Activated Amphiphile for Enhanced Photodynamic Therapy

Author:
Yudong Xue; Jia Tian; Zhiyong Liu; Jianbo Chen; Mengsi Wu; Yongjia Shen; Weian Zhang
Source:
Biomacromolecules 2019 v.20 no.7 pp. 2796-2808
ISSN:
1526-4602
Subject:
antineoplastic activity; biosecurity; cytotoxicity; fluorescence; glutathione; image analysis; micelles; neoplasms; photochemotherapy; photosensitizing agents; phototoxicity; polyethylene glycol; singlet oxygen; surfactants; thiols; tissues
Abstract:
... The development of more efficient photosensitizers with minimal damage to surrounding normal tissues has been a valuable and challenging subject during photodynamic therapy (PDT). Herein, a stimuli-activated porphyrinic photosensitizer (PEG-TPP-DNB; PEG = poly(ethylene glycol); TPP = 5,10,15,20-tetraphenylporphyrin; DNB = 2,4-dinitrobenzene) with capabilities of fluorescence and, remarkably, singl ...
DOI:
10.1021/acs.biomac.9b00581

32. A Targeted and pH-Responsive Bortezomib Nanomedicine in the Treatment of Metastatic Bone Tumors

Author:
Mingming Wang; Xiaopan Cai; Jian Yang; Changping Wang; Lu Tong; Jianru Xiao; Lei Li
Source:
ACS applied materials & interfaces 2018 v.10 no.48 pp. 41003-41011
ISSN:
1944-8252
Subject:
adverse effects; antineoplastic activity; antineoplastic agents; bone resorption; breast neoplasms; catechol; cytotoxicity; dendrimers; ligands; metastasis; models; moieties; nanomedicine; neoplasm cells; pH; peripheral nervous system diseases; pharmacokinetics; polyethylene glycol; proteasome inhibitors
Abstract:
... Bortezomib is a boronate proteasome inhibitor widely used as an efficient anticancer drug; however, the clinical use of bortezomib is hampered by its adverse effects such as hematotoxicity and peripheral neuropathy, and low efficacy on solid tumors due to unfavorable pharmacokinetics and poor penetration in the solid tumors. In this study, we developed a tripeptide Arg–Gly–Asp (RGD)-targeted dendr ...
DOI:
10.1021/acsami.8b07527

33. A bibenzyl from Dendrobium ellipsophyllum induces apoptosis in human lung cancer cells

Author:
Anirut Hlosrichok; Somruethai Sumkhemthong; Boonchoo Sritularak; Pithi Chanvorachote; Chatchai Chaotham
Source:
Natural medicines 2018 v.72 no.3 pp. 615-625
ISSN:
1340-3443
Subject:
B-cell lymphoma; Dendrobium; antineoplastic activity; antineoplastic agents; apoptosis; cytotoxicity; drug therapy; flow cytometry; humans; inhibitory concentration 50; lung neoplasms; mortality; necrosis; neoplasm cells; non-specific serine/threonine protein kinase; patients; viability assays
Abstract:
... Failure of current chemotherapeutic drugs leads to the recurrence of tumor pathology and mortality in lung cancer patients. This study aimed to evaluate the anticancer activity and related mechanisms of 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (TDB), a bibenzyl extracted from Dendrobium ellipsophyllum Tang and Wang, in human lung cancer cells. Cytotoxicity of TDB (0–300 µM) in different types of h ...
DOI:
10.1007/s11418-018-1186-x

34. A biocompatible and cathepsin B sensitive nanoscale system of dendritic polyHPMA-gemcitabine prodrug enhances antitumor activity markedly

Author:
Yan DaiThese authors contributed equally.; Xuelei Ma; Yanhong Zhang; Kai Chen; James Z. Tang; Qiyong Gong; Kui Luo
Source:
Biomaterials science 2018 v.6 no.11 pp. 2976-2986
ISSN:
2047-4849
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; biocompatibility; biosafety; breast neoplasms; cathepsin B; composite polymers; cytotoxicity; excretion; immunohistochemistry; mice; models; molecular weight; polymerization; therapeutics
Abstract:
... In an attempt to improve the therapeutic indices of gemcitabine (GEM), a prodrug was designed by conjugating GEM with a stimuli-responsive dendritic polyHPMA copolymer (dendritic polyHPMA-GEM) and synthesized using the one-pot method of RAFT polymerization. The prodrug with dendritic architectures was able to aggregate and form stable nanoscale systems in the order of 46 nm. The high molecular wei ...
DOI:
10.1039/c8bm00946e

35. A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells

Author:
Isabel Borrás-Linares; Almudena Pérez-Sánchez; Jesús Lozano-Sánchez; Enrique Barrajón-Catalán; David Arráez-Román; Alejandro Cifuentes; Vicente Micol; Antonio Segura Carretero
Source:
Food and chemical toxicology 2015 v.80 pp. 215-222
ISSN:
0278-6915
Subject:
active ingredients; antineoplastic activity; betulinic acid; bioactive compounds; chromatography; colorectal neoplasms; cytotoxicity; diterpenoids; fractionation; humans; models; neoplasm cells; phenolic compounds; rosemary; synergism; toxicology; viability
Abstract:
... Rosemary extracts have exhibited potential cytostatic or cytotoxic effects in several cancer cell models but their bioactive compounds are yet to be discovered. In this work, the anticancer activity of a rosemary-leaf extract and its fractions were assayed to identify the phenolic compounds responsible for their antiproliferative/cytotoxic effects on a panel of human colon cancer cell lines. Biogu ...
DOI:
10.1016/j.fct.2015.03.013

36. A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis

Author:
Ting Ge; Zhang Weiwei; Fei Ge; Longbao Zhu; Ping Song; Wanzheng Li; Lin Gui; Wan Dong; Yugui Tao; Kai Yang
Source:
Biomaterials science 2022 v.10 no.7 pp. 1831-1843
ISSN:
2047-4849
Subject:
antineoplastic activity; apoptosis; biocompatible materials; cell cycle; coordination polymers; cytotoxicity; dimensional stability; drug carriers; drug resistance; drug therapy; fluorouracil; human cell lines; metastasis; mice; near infrared radiation; neoplasms; photothermotherapy; polyethylene glycol; thermal stability
Abstract:
... Chemotherapy is a conventional treatment method for metastatic bone cancer, but it has limitations, such as lower drug-targeting of bone tissues and serious side effects. Bone metastasis almost always occurs in advanced cancer, and most patients in this period have strong drug resistance, which further worsens the curative effect. To address the above-mentioned difficulties, a drug delivery platfo ...
DOI:
10.1039/d1bm01717a

37. A chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation

Author:
Xiang-xiang Jin; Ya-nan Mei; Zhe Shen; Ju-fan Zhu; Sun-hui Xing; Hua-mao Yang; Guang Liang; Xiao-hui Zheng
Source:
Phytomedicine 2022 v.101 pp. 154087
ISSN:
0944-7113
Subject:
DNA damage; DNA replication; adhesion; antineoplastic activity; apoptosis; breast neoplasms; cell adhesion; cell cycle checkpoints; cell proliferation; chalcone; cytotoxicity; drugs; flow cytometry; fluorescence microscopy; hybrids; neoplasm cells; non-specific protein-tyrosine kinase; phosphorylation; relapse; sequence analysis; signal transduction; transactivators; transcriptome
Abstract:
... Although triple-negative breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have a ...
DOI:
10.1016/j.phymed.2022.154087

38. A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer

Author:
Laxmi L. Koteswari; Seema Kumari; Anil B. Kumar; Rama Rao Malla
Source:
Natural product research 2020 v.34 no.22 pp. 3267-3274
ISSN:
1478-6427
Subject:
DNA damage; antineoplastic activity; apoptosis; bark; breast neoplasms; caspase-3; cell cycle checkpoints; cytotoxicity; human cell lines; neoplasm cells; phosphotransferases (kinases); procyanidins; research; spectral analysis; tamoxifen
Abstract:
... Albezia odoratissima has many health benefits. The present study investigated the isolation, characterization and anticancer activity of procyanidin C1 from A. odoratissima bark. Procyanidin C1 was isolated and characterized by IR, ¹³C NMR, ¹H NMR and LC-MS spectroscopic studies. Anticancer property of procyanidin C1 was explored by studying the expression of checkpoint kinases, Bcl-2 and BAX, cel ...
DOI:
10.1080/14786419.2018.1557173

39. A comparative study on cytotoxicity and antiproliferative activities of crude extracts and fractions from Iranian wild-growing and cultivated Agaricus spp.

Author:
Sharareh Rezaeian; Hamid R. Pourianfar
Source:
Journal of food measurement & characterization 2018 v.12 no.4 pp. 2377-2384
ISSN:
2193-4126
Subject:
Agaricus bisporus; antineoplastic activity; antioxidants; breast neoplasms; cell growth; cytopathogenicity; cytotoxicity; ethyl acetate; human cell lines; mushrooms; prostatic neoplasms; thin layer chromatography
Abstract:
... Little is known about anticancer capability of wild-growing mushrooms belonging to Agaricus spp. in comparison with their cultivated counterparts. The present study was done to evaluate in vitro antiproliferative effects of dichloromethane-methanol (1:1, v/v) extracts obtained from several Iranian wild strains of Agaricus spp. in comparison with the cultivated white button mushroom, A. bisporus. T ...
DOI:
10.1007/s11694-018-9854-9

40. A comprehensive review on angel's trumpet (Brugmansia suaveolens)

Author:
Swati Pundir; Monu Kumar Shukla; Amardeep Singh; Raveen Chauhan; Uma Ranjan Lal; Aalia Ali; Deepak Kumar
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Brugmansia suaveolens; antineoplastic activity; antiseptics; arthritis; atropine; dermatitis; fungi; glycosides; ingredients; leaves; pain; phytochemicals; terpenoids; toxicity; Africa; Asia; Australia; Europe
Abstract:
... Angel's trumpet or Brugmanisa suaveolens (B. suaveolens), belonging to the family Solanaceae, distributed in Africa, America, Europe, Australia and Asia, has been used traditionally for the treatment of arthritis, sores, pain, inflammation, ulcers, abscesses, dermatitis, wounds, dysmenorrhea, fungal infections of the skin and as vaginal antiseptic in white secretions. Phytochemical studies of B. s ...
DOI:
10.1016/j.sajb.2022.02.023

41. A convergent synthetic platform for anticancer drugs formulation with nanoparticle delivery for the treatment and nursing care of glioma cancer

Author:
Xiaoying Wang; Haiqing Dong
Source:
Process biochemistry 2021 v.111 pp. 172-180
ISSN:
1359-5113
Subject:
antineoplastic activity; apoptosis; carcinoma; cytotoxicity; dose response; drug delivery systems; glioma; intravenous injection; paclitaxel
Abstract:
... The cytotoxicity of targeted combinational chemotherapy is significantly more significant than that of other approaches. This study aimed to develop compostable poly(caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCECs) nanomaterials (NMs) for the delivery of irinotecan (SN38) and paclitaxel (PTX) to examine the anticancer effect of (PTX@SN38-NMs) against glioma carcinoma cells in vivo a ...
DOI:
10.1016/j.procbio.2021.10.020

42. A critical review on exploiting the pharmaceutical potential of plant endophytic fungi

Author:
Shubhpriya Gupta; Preeti Chaturvedi; Manoj G. Kulkarni; Johannes Van Staden
Source:
Biotechnology advances 2020 v.39 pp. 107462
ISSN:
0734-9750
Subject:
antineoplastic activity; antioxidants; bioactive compounds; bioinformatics; biosynthesis; cytotoxicity; endophytes; fungi; high-throughput nucleotide sequencing; industry; medicine; metabolomics; metagenomics; multilocus sequence typing; secondary metabolites; world markets
Abstract:
... The escalating demand for secondary metabolites in international markets poses a severe threat to many plant species. An unscrupulous collection is also the immediate challenge to the survival of many unthreatened as well as vulnerable plants. Fungal endophytes have emerged in recent years as a promising substitute for sources of plant secondary metabolites. Many appealing secondary metabolites wi ...
DOI:
10.1016/j.biotechadv.2019.107462

43. A cytotoxic Petiveria alliacea dry extract induces ATP depletion and decreases β-F1-ATPase expression in breast cancer cells and promotes survival in tumor-bearing mice

Author:
John F. Hernández; Claudia P. Urueña; Tito A. Sandoval; Maria C. Cifuentes; Laura Formentini; Jose M. Cuezva; Susana Fiorentino
Source:
Revista Brasileira de Farmacognosia 2017 v.27 no.3 pp. 306-314
ISSN:
0102-695X
Subject:
Petiveria alliacea; adenosine triphosphate; antineoplastic activity; breast neoplasms; cell proliferation; cell viability; cytotoxicity; glycolysis; leaf extracts; leukemia; mice; mitochondria; models; neoplasm cells; nutrients; oxidative phosphorylation; oxygen; oxygen consumption; traditional medicine
Abstract:
... Metabolic plasticity in cancer cells assures cell survival and cell proliferation under variable levels of oxygen and nutrients. Therefore, new anticancer treatments endeavor to target such plasticity by modifying main metabolic pathways as glycolysis or oxidative phosphorylation. In American traditional medicine Petiveria alliacea L., Phytolaccacea, leaf extracts have been used for leukemia and b ...
DOI:
10.1016/j.bjp.2016.09.008

44. A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma

Author:
Jingjing Zhang; Yangliu Tong; Xun Lu; Fangming Dong; Xiaoxuan Ma; Shiyu Yin; Ying He; Yonghong Liu; Qingchao Liu; Daidi Fan
Source:
Life sciences 2022 v.304 pp. 120698
ISSN:
0024-3205
Subject:
Oriental traditional medicine; acetylation; adverse effects; antineoplastic activity; apoptosis; cytotoxicity; death; flow cytometry; fluorescent antibody technique; ginsenosides; growth and development; hepatoma; immunoblotting; models; neoplasm cells; phosphorylation; transcription factors; transcriptomics; xenotransplantation
Abstract:
... Epidemiological studies have shown that hepatocellular carcinoma (HCC) is a main cause of tumor death worldwide. Accumulating data indicate that ginsenoside CK is an effective compound for preventing HCC growth and development. However, improvement of pharmaceutical effect of the ginsenoside CK is still needed. In our study, we performed acetylation of ginsenoside CK (CK-3) and investigated the an ...
DOI:
10.1016/j.lfs.2022.120698

45. A dextran–platinum(iv) conjugate as a reduction-responsive carrier for triggered drug release

Author:
Shasha He; Yuwei Cong; Dongfang Zhou; Jizhen Li; Zhigang Xie; Xuesi Chen; Xiabin Jing; Yubin Huang
Source:
Journal of materials chemistry B 2015 v.3 no.41 pp. 8203-8211
ISSN:
2050-7518
Subject:
antineoplastic activity; cytotoxicity; dextran; doxorubicin; hydrophilicity; hydrophobicity; nanocarriers; platinum
Abstract:
... Reduction-responsive nano-carriers have been confirmed to be promising for intracellular drug delivery. To develop multifunctional polymer-based drug delivery system, a novel dextran–Pt(iv) conjugate was synthesized by conjugating Pt(iv) to the side chains of the hydrophilic dextran and used for doxorubicin (DOX) delivery. Pt(iv) conjugation could change the hydrophilicity of dextran, leading to t ...
DOI:
10.1039/c5tb01496d

46. A direct route towards preparing pH-sensitive graphene nanosheets with anti-cancer activity

Author:
Dickson Joseph; Nisha Tyagi; Aabhash Ghimire; Kurt E. Geckeler
Source:
RSC advances 2013 v.4 no.8 pp. 4085-4093
ISSN:
2046-2069
Subject:
antineoplastic activity; atomic force microscopy; cell viability; cytotoxicity; dispersions; graphene; lysozyme; nanogold; nanoparticles; nanosheets; pH; proteins; sonication; ultrasonic treatment
Abstract:
... Graphene nanosheets were prepared by the direct exfoliation of graphite in an aqueous lysozyme solution using ultrasonication. Atomic force microscopy studies indicated that the nanosheets possessed small lateral dimensions of less than three layers. Raman spectroscopy suggested that defects were introduced by the sonication process. These defects were primarily edge defects, not basal-plane defec ...
DOI:
10.1039/c3ra45984e

47. A facile and efficient synthesis of hexahydro-1H-pyrido[2,3-b]indol-2-one scaffolds via a sequential Michael addition/amidation/reductive cyclization process

Author:
Xiong-Li Liu; Wen-Hui Zhang; Zhen Yao; Xiong-Wei Liu; Li-Jun Peng; Zhi Zhao; Yi Lu; Ying Zhou; Wei-Cheng Yuan
Source:
Tetrahedron 2015 v.71 pp. 9483-9495
ISSN:
0040-4020
Subject:
antineoplastic activity; chemical reactions; chemical structure; cisplatin; cytotoxicity; humans; in vitro studies; lung neoplasms; neoplasm cells; organic compounds; prostatic neoplasms
Abstract:
... A new methodology was developed for the synthesis of hexahydro-1H-pyrido[2,3-b]indol-2-one scaffolds via a sequential Michael addition/amidation/reductive cyclization process. A wide variety of products bearing a hexahydro-1H-pyrido[2,3-b]indol-2-one core with varying degrees of substitution around it, which is a key structural skeleton found in a large number of biologically active natural produc ...
DOI:
10.1016/j.tet.2015.10.039

48. A facile and efficient synthesis of polycyclic spiropyrrolidine oxindoles bearing mesityl oxide unit via a three-component 1,3-dipolar cycloaddition reaction

Author:
Hui-Juan Wang; Bo-Wen Pan; Wen-Hui Zhang; Chao Yang; Xiong-Li Liu; Zhi Zhao; Ting-Ting Feng; Ying Zhou; Wei-Cheng Yuan
Source:
Tetrahedron 2015 v.71 pp. 8131-8139
ISSN:
0040-4020
Subject:
antineoplastic activity; carbon; chemical structure; cisplatin; cycloaddition reactions; cytotoxicity; humans; hydrophobicity; in vitro studies; ingredients; lung neoplasms; neoplasm cells; organic compounds; proline; prostatic neoplasms
Abstract:
... A facile and efficient methodology was developed for the synthesis of multifunctional polycyclic spiropyrrolidine oxindoles bearing mesityl oxide unit via a three-component 1,3-dipolar cycloaddition reaction of dienones 2 with azomethine ylides (thermally generated in situ from isatin derivatives and proline or thioproline). Products bearing adjacent four chiral carbon centers were smoothly obtain ...
DOI:
10.1016/j.tet.2015.08.041

49. A family of complexes with N-scorpionate-type and other N-donor ligands obtained in situ from pyrazole derivative and zerovalent cobalt. Physicochemical and cytotoxicity studies

Author:
A. Adach; M. Daszkiewicz; M. Tyszka-Czochara
Source:
RSC advances 2016 v.6 no.50 pp. 44070-44079
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-radiation; adenocarcinoma; antineoplastic activity; cations; cobalt; crystal structure; cytotoxicity; hepatoma; ligands; lung neoplasms; neoplasm cells; nitrogen; zinc
Abstract:
... In situ syntheses and X-ray structures of three novel cationic–anionic complexes: [CoL¹Br][ZnL²L³ZnBr₅] (1), and [CoL¹Cl][ZnL³Br₃] (2) and [CoL¹Cl][ZnL³Cl₃] (3) L¹ = N,N,N-tris(3,5-dimethylpyrazol-1-ylmethyl)amine, L² = hexamethylenetetramine (urotropine), L³ = 3,5-dimethylpyrazole, have been reported. The presence of three different organic ligands (L¹, L² and L³) in isolated complexes results fr ...
DOI:
10.1039/c6ra06439f

50. A focal adhesion kinase inhibitor 16-hydroxy-cleroda-3,13-dien-16,15-olide incorporated into enteric-coated nanoparticles for controlled anti-glioma drug delivery

Author:
Varadharajan Thiyagarajan; Shi-Xiang Lin; Chia-Hung Lee; Ching-Feng Weng
Source:
Colloids and surfaces 2016 v.141 pp. 120-131
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; Polyalthia longifolia; X-ray diffraction; antineoplastic activity; antineoplastic agents; apoptosis; brain; colloids; cytotoxicity; gastric acid; gastrointestinal system; leaching; medicinal plants; membrane potential; mice; mitochondrial membrane; nanoparticles; non-specific protein-tyrosine kinase; pH; physical properties; polymers; porous media; reactive oxygen species; scanning electron microscopy; silica; solubility; synergism; transmission electron microscopy; zeta potential
Abstract:
... 16-Hydroxy-cleroda-3,13-dien-16,15-olide (HCD) which is extracted from a medicinal plant, Polyalthia longifolia, was shown to exhibit anticancer activity through apoptosis and FAK inhibition in our previous study. To improve its solubility and efficacy, a novel HCD delivery system using copper-substituted mesoporous silica nanoparticles (MSNs) was designed as a delivery vehicle, and the outer surf ...
DOI:
10.1016/j.colsurfb.2016.01.038