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- Author:
- Hongbo Chen; Xiaohui Hu; Yong Lan; Su Chen; Xiaolong Xiang; Yulong Tan; Guang Zeng; Zicheng Guo; Kailing Li; Junfeng Zhang
- Source:
- Journal of functional foods 2022 v.91 pp. 105032
- ISSN:
- 1756-4646
- Subject:
- antineoplastic activity; apoptosis; bioinformatics; computer software; databases; flow cytometry; genes; immunohistochemistry; urinary bladder neoplasms
- Abstract:
- ... This study aims to explore the mechanism of puerarin regulating the proliferation, apoptosis and senescence of T24 and EJ cells via miR-139-5p/CCNB1 and PI3K/AKT pathways. Initially, Cell Counting Kit (CCK)-8, flow cytometry, β-galactosidase detection kit, and RT-qPCR are used to assess the effect of puerarin on the proliferation apoptosis and senescence of bladder cancer cells by regulating miR-1 ...
- DOI:
- 10.1016/j.jff.2022.105032
- https://doi.org/10.1016/j.jff.2022.105032
- Author:
- Yang Shen; Hesong Ye; Dongjian Zhang; Ming Yang; Yuanyuan Ji; Longlong Tang; Xudong Zhu; Lin Yuan
- Source:
- Gene 2022 v.821 pp. 146269
- ISSN:
- 0378-1119
- Subject:
- antineoplastic activity; apoptosis; bladder; data collection; exosomes; flow cytometry; fluorescence; gene expression; genes; metastasis; microarray technology; phenotype; quantitative polymerase chain reaction; transmission electron microscopy; urinary bladder neoplasms
- Abstract:
- ... Bladder cancer is a malignant tumor characterized by high recurrence and persistence due to the limited therapies that are currently available. Hirudin exerts a strong anticancer effect on several tumors. Thus, it is urgent to explore the biological function of hirudin in bladder cancer and the role of bladder cancer-derived exosomes in tumor inhibition. First, a network pharmacology analysis was ...
- DOI:
- 10.1016/j.gene.2022.146269
- https://doi.org/10.1016/j.gene.2022.146269
- Author:
- Weigang Ren; Jiannan Ren; Naiwen Zhang; Xinlin Liu; Yao Deng; Yanyan Jiang; Bin Yan; Xiaoxiong Xiao; Haixin Yu
- Source:
- Biochemical and biophysical research communications 2022 v.613 pp. 12-18
- ISSN:
- 0006-291X
- Subject:
- antineoplastic activity; immune response; research; sequence analysis; urinary bladder neoplasms
- Abstract:
- ... Bladder cancer (BC) is one of the most common malignant tumors of the urinary system worldwide. To date, immune checkpoint inhibitors (including PD-1/PD-L1) have been applied to treat patients with bladder cancer in the clinic and achieved the promising outcome. Further improvement of the anticancer efficiency of these immune therapies is crucial for bladder cancer. Our previous RNA-seq data on CB ...
- DOI:
- 10.1016/j.bbrc.2022.04.114
- https://doi.org/10.1016/j.bbrc.2022.04.114
- Author:
- Edgar Tavares-da-Silva; Eurico Pereira; Ana S. Pires; Ana R. Neves; Catarina Braz-Guilherme; Inês A. Marques; Ana M. Abrantes; Ana C. Gonçalves; Francisco Caramelo; Rafael Silva-Teixeira; Fernando Mendes; Arnaldo Figueiredo; Maria Filomena Botelho
- Source:
- Biology 2021 v.10 no.1 pp. -
- ISSN:
- 2079-7737
- Subject:
- antineoplastic activity; assays; biochemical pathways; cancer therapy; cell cycle checkpoints; cell lines; cell proliferation; cell viability; exposure duration; flow cytometry; fluorescence; glutathione; interphase; membrane potential; mitochondrial membrane; neoplasm cells; nitric oxide; nitrogen; nonthermal processing; oxygen; protein content; toxicity testing; urinary bladder neoplasms
- Abstract:
- ... Antitumor therapies based on Cold Atmospheric Plasma (CAP) are an emerging medical field. In this work, we evaluated CAP effects on bladder cancer. Two bladder cancer cell lines were used, HT-1376 (stage III) and TCCSUP (stage IV). Cell proliferation assays were performed evaluating metabolic activity (MTT assay) and protein content (SRB assay). Cell viability, cell cycle, and mitochondrial membra ...
- DOI:
- 10.3390/biology10010041
- https://doi.org/10.3390/biology10010041
- Author:
- Parisa Zargar; Shabnaz Koochakkhani; Marziyeh Hassanzadeh; Yaghoub Ashouri Taziani; Hamid Nasrollahi; Ebrahim Eftekhar
- Source:
- Molecular biology reports 2022 v.49 no.4 pp. 2755-2763
- ISSN:
- 0301-4851
- Subject:
- acriflavine; adjuvants; antineoplastic activity; cisplatin; drug therapy; gene expression; humans; mechanism of action; molecular biology; quantitative polymerase chain reaction; urinary bladder neoplasms
- Abstract:
- ... BACKGROUND: Resistance to cisplatin is a major obstacle to effective treatment of bladder cancer (BC). The present study aimed to determine whether a combination of acriflavine (ACF) with cisplatin could potentiate the antitumor property of cisplatin against the BC cells. Furthermore, the molecular mechanism behind the anticancer action of ACF was considered. METHODS AND RESULTS: Two human BC cell ...
- DOI:
- 10.1007/s11033-021-07087-1
- https://doi.org/10.1007/s11033-021-07087-1
- Author:
- Hui‐qiong Zhang; Xiao‐fang Xie; Gang‐min Li; Jun‐ren Chen; Meng‐ting Li; Xin Xu; Qiu‐yun Xiong; Guan‐ru Chen; Yan‐peng Yin; Fu Peng; Yan Chen; Cheng Peng
- Source:
- Phytotherapy research 2021 v.35 no.8 pp. 4511-4525
- ISSN:
- 0951-418X
- Subject:
- Dendrobium chrysotoxum; Western blotting; antineoplastic activity; apoptosis; carcinoma; cell growth; cytotoxicity; fluorescence; growth retardation; humans; immune response; interleukin-10; kidneys; lung neoplasms; lungs; mice; models; necrosis; neoplasm cells; oral administration; phosphatidylinositol 3-kinase; phytotherapy; rapamycin; research; spleen; urinary bladder neoplasms; uterine cervical neoplasms; xenotransplantation
- Abstract:
- ... Erianin is a small‐molecule compound that is isolated from Dendrobium chrysotoxum Lindl. In recent years, it has been found to have evident antitumor activity in various cancers, such as bladder cancer, cervical cancer, and nasopharyngeal carcinoma. In this study, we assessed the effect of erianin on lung cancer in terms of cell growth inhibition and the related mechanism. First, erianin at a conc ...
- DOI:
- 10.1002/ptr.7154
- https://doi.org/10.1002/ptr.7154
- Author:
- Bruno Silveira Adami; Fernando Mendonça Diz; Gustavo Petry Oliveira Gonçalves; Camille Kirinus Reghelin; Matheus Scherer; Artur Pereira Dutra; Ricardo Meurer Papaléo; Jarbas Rodrigues de Oliveira; Fernanda Bueno Morrone; Andrea Wieck; Léder Leal Xavier
- Source:
- Micron 2021 v.151 pp. 103152
- ISSN:
- 0968-4328
- Subject:
- antineoplastic activity; apoptosis; atomic force microscopy; cell viability; cytotoxicity; dose response; humans; lactate dehydrogenase; morphometry; quercetin; roughness; toxicity testing; urinary bladder neoplasms
- Abstract:
- ... Quercetin is a flavonoid found in a great variety of foods such as vegetables and fruits. This compound has been shown to inhibit the proliferation of various types of cancer cells, as well as the growth of tumors in animal models. In the present study, we analyze morphological and mechanical changes produced by quercetin in T24 bladder cancer cells. Decreased cell viability and cell number were o ...
- DOI:
- 10.1016/j.micron.2021.103152
- https://doi.org/10.1016/j.micron.2021.103152
- Author:
- Jialin Li; Wenlong Ma; Xiangming Cheng; Xuebin Zhang; Yi Xie; Zhigang Ji; Song Wu
- Source:
- Archives of biochemistry and biophysics 2020 v.687 pp. 108363
- ISSN:
- 0003-9861
- Subject:
- Paris polyphylla; animal models; antineoplastic activity; apoptosis; cell cycle checkpoints; cell proliferation; cytotoxicity; drug therapy; human diseases; mice; neoplasm cells; signal transduction; transcription factors; urinary bladder neoplasms
- Abstract:
- ... Polyphyllin I (PPI), an extract from Paris polyphylla, has been demonstrated to possess antitumor activity against multiple cancers. However, whether PPI can inhibit bladder cancer (BCa) and the underlying mechanisms have never been researched. In this study, we initially found that PPI could induce BCa cell apoptosis and cell cycle arrest, as well as inhibit cell proliferation in vitro. Additiona ...
- DOI:
- 10.1016/j.abb.2020.108363
- https://doi.org/10.1016/j.abb.2020.108363
- Author:
- Gizele Lucia da Costa Pereira; Tamires Cunha Almeida; Janaina Brandão Seibert; Tatiane Roquete Amparo; Rodrigo Dian de Oliveira Aguiar Soares; Ivanildes Vasconcelos Rodrigues; Gustavo Henrique Bianco de Souza; Orlando David Henrique dos Santos; Glenda Nicioli da Silva
- Source:
- Natural product research 2021 v.35 no.23 pp. 5238-5242
- ISSN:
- 1478-6427
- Subject:
- Cymbopogon; antineoplastic activity; apoptosis; cell cycle; cell movement; cell proliferation; cell viability; computer simulation; computer software; cytotoxicity; essential oils; gas chromatography; hydrodistillation; mass spectrometry; mechanism of action; oils; research; urinary bladder neoplasms
- Abstract:
- ... The aim of this study was to analyse the antitumor effect of the Cymbopogon densiflorus essential oil in silico and in vitro on bladder cancer cells RT4 and T24, with different TP53 status. The oil was extracted by hydrodistillation and the gas chromatography coupled to the mass spectrometry was used for characterisation. In silico analysis was carried out by Pass online software. Cytotoxicity, ce ...
- DOI:
- 10.1080/14786419.2020.1747453
- https://doi.org/10.1080/14786419.2020.1747453
- Author:
- C.C.F. do-Amaral; B.S. Pacheco; F.K. Seixas; C.M.P. Pereira; T. Collares
- Source:
- Algal research 2020 v.47 pp. 101884
- ISSN:
- 2211-9264
- Subject:
- Phaeophyceae; adverse effects; antineoplastic activity; apoptosis; biochemical pathways; cancer therapy; cell lines; chemical structure; dietary supplements; drug therapy; fucoidan; models; neoplasm cells; patients; urinary bladder neoplasms
- Abstract:
- ... Fucoidans are natural compounds derived from brown algae that are known for various biological activities. The mechanisms underlying these activities are being widely studied and are not yet fully understood. The results obtained so far have pointed to fucoidans being promising molecules capable of serving as an adjunct to anticancer therapy, or even as dietary supplementation in cancer patients. ...
- DOI:
- 10.1016/j.algal.2020.101884
- https://doi.org/10.1016/j.algal.2020.101884
- Author:
- Tianbao Yang; Huiai Lu; Yixuan Shu; Yifeng Ou; Ling Hong; Chak-Tong Au; Renhua Qiu
- Source:
- Organic letters 2020 v.22 no.3 pp. 827-831
- ISSN:
- 1523-7052
- Subject:
- air; aldehydes; alkylation; antineoplastic activity; chemical structure; human cell lines; indoles; ketones; neoplasm cells; oxygen; ultraviolet radiation; urinary bladder neoplasms
- Abstract:
- ... A concise, one-step route to produce 3,3′-diindolylmethanes (DIMs) from simple indoles and ketones or aldehydes is reported. The key step is the ready formation of indole derivatives that involves the in situ conversion of CF₃SO₂Na reagent to ·CF₃ under oxygen or air (1.0 atm) and UV irradiation. It is disclosed that most of the obtained DIMs show anticancer activities in human bladder cancer cell ...
- DOI:
- 10.1021/acs.orglett.9b04272
- https://doi.org/10.1021/acs.orglett.9b04272
12. Effects of Mycobacterium bovis Calmette et Guérin (BCG) in oncotherapy: Bladder cancer and beyond
- Author:
- Neelam Mukherjee; Esther Julián; Jordi B. Torrelles; Robert S. Svatek
- Source:
- Vaccine 2021 v.39 no.50 pp. 7332-7340
- ISSN:
- 0264-410X
- Subject:
- Mycobacterium bovis; adults; antineoplastic activity; childhood; immunity; macrophages; neutrophils; tuberculosis; urinary bladder neoplasms; vaccination; vaccines
- Abstract:
- ... The Mycobacterium bovis Bacillus Calmette et Guérin (BCG) vaccine was generated in 1921 with the efforts of a team of investigators, Albert Calmette and Camille Guérin, dedicated to the determination to develop a vaccine against active tuberculosis (TB) disease. Since then, BCG vaccination is used globally for protection against childhood and disseminated TB; however, its efficacy at protecting ag ...
- DOI:
- 10.1016/j.vaccine.2021.09.053
- https://doi.org/10.1016/j.vaccine.2021.09.053
- Author:
- Chao‐Yen Ho; An‐Chen Chang; Chung‐Hua Hsu; Te‐Fu Tsai; Yi‐Chia Lin; Kuang‐Yu Chou; Hung‐En Chen; Ji‐Fan Lin; Po‐Chun Chen; Thomas I‐Sheng Hwang
- Source:
- Environmental toxicology 2021 v.36 no.2 pp. 185-193
- ISSN:
- 1520-4081
- Subject:
- AMP-activated protein kinase; acridine orange; antifungal agents; antineoplastic activity; apoptosis; autophagy; cathepsin D; cell viability; ecotoxicology; lysosomes; miconazole; neoplasm cells; neoplasm progression; phosphorylation; research; staining; urinary bladder neoplasms
- Abstract:
- ... Autophagy plays a dual function in cancer progression; autophagy activation can support cancer cell survival or contribute to cell death. Miconazole, a Food and Drug Administration‐approved antifungal drug, has been implicated in oncology research recently. Miconazole was found to exert antitumor effects in various tumors, including bladder cancer (BC). However, whether it provokes protective auto ...
- DOI:
- 10.1002/tox.23024
- https://doi.org/10.1002/tox.23024
- Author:
- Shih-Ya Hung; Wu-Fu Chen; Yi-Chen Lee; Jui-Hsin Su; Yung-Shun Juan; In-Pin Lin; Ya-Hui Zhang; Ming-Kai Chang; Mei-Ying Lin; Chung-Yi Chen; Chien-Hsing Lee
- Source:
- Phytomedicine 2021 v.92 pp. 153720
- ISSN:
- 0944-7113
- Subject:
- DNA damage; Danio rerio; acridine orange; antineoplastic activity; apoptosis; autophagy; cell cycle; cysteine; cytotoxicity; death; flow cytometry; fluorescence microscopy; humans; membrane potential; mitochondria; mitochondrial membrane; models; mortality; reactive oxygen species; urinary bladder neoplasms; xenotransplantation
- Abstract:
- ... Bladder cancer (BC) is a very common type of malignant cancer in men and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that Rhopaloic acid A (RA), a compound isolated from marine sponges, fights cancer but its potential anti-tumor effect on BC is still unknown.The present study was aimed to explore the potential anti-tumor effects of RA again ...
- DOI:
- 10.1016/j.phymed.2021.153720
- https://doi.org/10.1016/j.phymed.2021.153720
15. Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress
- Author:
- Tsu-Ming Chien; Kuang-Han Wu; Ya-Ting Chuang; Yun-Chiao Yeh; Hui-Ru Wang; Bi-Wen Yeh; Chia-Hung Yen; Tzu-Jung Yu; Wen-Jeng Wu; Hsueh-Wei Chang
- Source:
- Antioxidants 2021 v.10 no.7 pp. -
- ISSN:
- 2076-3921
- Subject:
- DNA; DNA damage; Withania somnifera; acetylcysteine; antineoplastic activity; apoptosis; bioactive compounds; caspases; catalase; cell cycle; flow cytometry; glutathione-disulfide reductase; heme oxygenase (biliverdin-producing); membrane potential; mitochondria; mitochondrial membrane; oxidative stress; quinones; reactive oxygen species; superoxide dismutase; thioredoxins; urinary bladder neoplasms
- Abstract:
- ... Withaferin A (WFA), the Indian ginseng bioactive compound, exhibits an antiproliferation effect on several kinds of cancer, but it was rarely reported in bladder cancer cells. This study aims to assess the anticancer effect and mechanism of WFA in bladder cancer cells. WFA shows antiproliferation to bladder cancer J82 cells based on the finding of the MTS assay. WFA disturbs cell cycle progression ...
- DOI:
- 10.3390/antiox10071063
- https://doi.org/10.3390/antiox10071063
- Author:
- Claudia Lizet Meneses-Gutiérrez; Jacqueline Hernández-Damián; José Pedraza-Chaverri; Isabel Guerrero-Legarreta; Dario Iker Téllez; María Eugenia Jaramillo-Flores
- Source:
- Antioxidants 2019 v.8 no.7 pp. -
- ISSN:
- 2076-3921
- Subject:
- antineoplastic activity; antioxidant activity; catechin; cisplatin; copper; cytotoxicity; epicatechin; human cell lines; humans; iron; metal ions; neoplasm cells; oxidation; peroxidase; polymerization; reactive oxygen species; resveratrol; therapeutics; urinary bladder neoplasms
- Abstract:
- ... In this work the polymerization of catechin, epicatechin, and resveratrol was carried out through a peroxidase oxidation process in order to improve the biological activity of these phenolic compounds. The antioxidant activity of the oligomers was evaluated by their ability to scavenge reactive oxygen species (ROS) and their capacity to chelate metal ions Fe2+ and Cu2+. The antitumor effect of the ...
- DOI:
- 10.3390/antiox8070214
- PubMed:
- 31295839
- PubMed Central:
- PMC6680426
- https://doi.org/10.3390/antiox8070214
- Author:
- Xi-Lin Ouyang; Li Yang; Lei Huang; Ying-Ming Pan
- Source:
- Natural product research 2020 v.34 no.18 pp. 2689-2693
- ISSN:
- 1478-6427
- Subject:
- Camellia; antineoplastic activity; calcium; cells; cytotoxicity; ellagic acid; ethanol; fruits; humans; ions; reactive oxygen species; research; urinary bladder neoplasms
- Abstract:
- ... In this study, antitumor activity and composition analysis of the core of Camellia osmantha fruit were investigated. The cores were extracted by 80% ethanol to obtain the crude extract (TF), which was successively distributed by different concentrations of ethanol with MCI resin to obtain three different parts (Frs 1 to 3). Cytotoxicity activities showed that TF, Fr-2, and Fr-3 exhibited good inhi ...
- DOI:
- 10.1080/14786419.2018.1550763
- https://doi.org/10.1080/14786419.2018.1550763
- Author:
- Te‐Fu Tsai; Po‐Chun Chen; Yi‐Chia Lin; Kuang‐Yu Chou; Hung‐En Chen; Chao‐Yen Ho; Ji‐Fan Lin; Thomas I‐S. Hwang
- Source:
- Environmental toxicology 2020 v.35 no.1 pp. 47-54
- ISSN:
- 1520-4081
- Subject:
- Brassicaceae; antineoplastic activity; benzyl isothiocyanate; cell lines; enzyme activity; fibroblast growth factor receptor 3; fluorescent antibody technique; luciferase; mitogen-activated protein kinase; neoplasm cells; phosphorylation; signal transduction; transcription factors; transcriptional activation; urinary bladder neoplasms
- Abstract:
- ... Benzyl isothiocyanate (BITC), a bioactive natural product present in cruciferous vegetables, has been proved to prevent cancer progression through various mechanisms. In our previous report, we proved that BITC exhibits antitumor effects in bladder cancer by suppressing IGF1R, FGFR3, and mTOR, which is mediated by miR‐99a expression. In this study, we identified the signal pathway involved in regu ...
- DOI:
- 10.1002/tox.22841
- https://doi.org/10.1002/tox.22841
- Author:
- Sandra Guallar-Garrido; Víctor Campo-Pérez; Alejandro Sánchez-Chardi; Marina Luquin; Esther Julián
- Source:
- Microorganisms 2020 v.8 no.5 pp. -
- ISSN:
- 2076-2607
- Subject:
- Mycobacterium bovis BCG; antineoplastic activity; biomass production; carbon; cell growth; culture media; immunotherapy; nitrogen; patients; urinary bladder neoplasms
- Abstract:
- ... Mycobacterium bovis bacillus Calmette-Guérin (BCG) remains the first treatment option for non-muscle-invasive bladder cancer (BC) patients. In research laboratories, M. bovis BCG is mainly grown in commercially available media supplemented with animal-derived agents that favor its growth, while biomass production for patient treatment is performed in Sauton medium which lacks animal-derived compon ...
- DOI:
- 10.3390/microorganisms8050734
- https://doi.org/10.3390/microorganisms8050734
- Author:
- Pengyu Guo; Lu Wang; Wenting Shang; Jiuwei Chen; Ziyin Chen; Feng Xiong; Ziqi Wang; Zhichao Tong; Keliang Wang; Liming Yang; Jie Tian; Wanhai Xu
- Source:
- ACS applied materials & interfaces 2020 v.12 no.49 pp. 54367-54377
- ISSN:
- 1944-8252
- Subject:
- adhesion; antigen presentation; antineoplastic activity; collagen; dextran; drug resistance; ferroptosis; gels; gold; immune response; immunostimulants; iron oxides; macrophages; nanorods; near infrared radiation; neoplasm cells; phenotype; photothermotherapy; remission; urinary bladder neoplasms
- Abstract:
- ... Bladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death of cancer cells as well as restoring tumor immune microenvironment need to be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers a combination of pho ...
- DOI:
- 10.1021/acsami.0c15176
- https://doi.org/10.1021/acsami.0c15176
- Author:
- Behnam Ashrafi; Marzieh Rashidipour; Elham Gholami; Ehsan Sattari; Abdolrazagh Marzban; Farnaz Kheirandish; Mojtaba Khaksarian; Morovat Taherikalani; Setareh Soroush
- Source:
- South African journal of botany 2020 v.135 pp. 109-116
- ISSN:
- 0254-6299
- Subject:
- Nepeta; aerial parts; anti-inflammatory activity; antifungal properties; antineoplastic activity; cell lines; chemical composition; cytotoxicity; dexamethasone; ears; essential oils; germacrene; habitats; hydrodistillation; immunity; inhibitory concentration 50; lung neoplasms; macrophages; mice; mint; morphine; mountains; neoplasm cells; pain; rats; urinary bladder neoplasms; Iran
- Abstract:
- ... Nepeta curvidens is a plant of the mint family and an important species of the genus Nepeta. The main habitat of the N. curvidens in the Garin Mountains in Lorestan Province, Iran. Although locals have used N. curvidens as a food flavoring agent for years, few studies have been conducted on its phytochemical and biological properties. The chemical constituents of N. curvidens essential oil and the ...
- DOI:
- 10.1016/j.sajb.2020.08.015
- https://doi.org/10.1016/j.sajb.2020.08.015
- Author:
- Wei‐Jung Chang; Bing‐Huei Chen; Baskaran Stephen Inbaraj; John‐Tung Chien
- Source:
- Journal of the science of food and agriculture 2019 v.99 no.6 pp. 3106-3116
- ISSN:
- 0022-5142
- Subject:
- Brassicaceae; allyl isothiocyanate; anti-inflammatory activity; antineoplastic activity; cytotoxicity; emulsions; epithelium; human cell lines; immune response; inducible nitric oxide synthase; interleukin-6; intestines; lipopolysaccharides; macrophages; nanoparticles; neoplasm cells; nitric oxide; oils; particle size; therapeutics; tumor necrosis factor-alpha; urinary bladder neoplasms; vegetables; water solubility
- Abstract:
- ... BACKGROUND: Allyl isothiocyanate (AITC), a volatile and water‐insoluble compound present in several cruciferous vegetables, has been shown to possess several biological qualities such as anti‐bacterial, anti‐fungal, and anti‐cancer activity. In this study, water‐soluble allyl isothiocyanate nanoparticles (AITC‐NPs) were prepared by oil dispersed in water (O/W) microemulsion and complex coacervatio ...
- DOI:
- 10.1002/jsfa.9524
- https://doi.org/10.1002/jsfa.9524
- Author:
- Chih‐Hung Chiang; Jing‐Gung Chung; Fei‐Ting Hsu
- Source:
- Environmental toxicology 2019 v.34 no.6 pp. 679-688
- ISSN:
- 1520-4081
- Subject:
- Western blotting; antineoplastic activity; apoptosis; body weight; dimethyl sulfoxide; flow cytometry; humans; mice; mitogen-activated protein kinase; protein content; reporter genes; transcription factor NF-kappa B; urinary bladder neoplasms; vascular endothelial growth factors
- Abstract:
- ... The aim of the present study is to investigate anticancer effect and mechanism of regorafenib in bladder cancer in vitro and in vivo. Human bladder cancer TSGH 8301 cells were treated with regorafenib, NF‐κB, AKT, or mitogen‐activated protein kinase (MAPK) inhibitors for different time. The changes of cell viability, NF‐κB activation, apoptotic signaling transduction, and expression of tumor progr ...
- DOI:
- 10.1002/tox.22734
- https://doi.org/10.1002/tox.22734
- Author:
- Yu-Hsiang Lee; Pham-Thi Tuyet
- Source:
- In vitro cellular & developmental biology 2019 v.55 no.6 pp. 395-404
- ISSN:
- 1071-2690
- Subject:
- absorption; antineoplastic activity; biological assessment; cell movement; death; humans; in vitro studies; metabolism; mortality; neoplasm cells; patients; quercetin; relapse; urinary bladder neoplasms
- Abstract:
- ... Bladder cancer is the 13th leading cause of cancer death worldwide, and its mortality rate is highly associated with the motility of the malignant cells. Although the techniques of urothelial cancer treatment have been continuously advanced in the last decade, the invasive bladder cancer remains incurable and the mean survival time of the patients with high-grade malignancy after cancer relapse is ...
- DOI:
- 10.1007/s11626-019-00363-2
- https://doi.org/10.1007/s11626-019-00363-2
- Author:
- Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
- Source:
- Phytomedicine 2019 v.56 pp. 156-164
- ISSN:
- 0944-7113
- Subject:
- Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
- Abstract:
- ... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
- DOI:
- 10.1016/j.phymed.2018.10.034
- https://doi.org/10.1016/j.phymed.2018.10.034
- Author:
- Aleksandar Dolashki; Pavlina Dolashka; Arnulf Stenzl; Stefan Stevanovic; Wilhelm K. Aicher; Lyudmila Velkova; Radostina Velikova; Wolfgang Voelter
- Source:
- Biotechnology, biotechnological equipment 2019 v.33 no.1 pp. 20-32
- ISSN:
- 1314-3530
- Subject:
- Rapana venosa; antineoplastic activity; apoptosis; biotechnology; bladder; carcinoma; cell growth; cell lines; doxorubicin; equipment; glycoproteins; glycosylation; hemocyanin; hexoses; humans; methylation; neoplasm cells; oligosaccharides; therapeutics; two-dimensional gel electrophoresis; urinary bladder neoplasms
- Abstract:
- ... Hemocyanins are oxygen-transporting glycoproteins in molluscs and arthropods. In this study, we assayed the biomacromolecules from the molluscs Helix lucorum (HlH), Rapana venosa (RvH) and Megatura crenulata (KLH) including their functional units (FUs), for therapy of bladder cancer permanent cells. In vitro studies antitumour activities of these proteins were performed with bladder cancer permane ...
- DOI:
- 10.1080/13102818.2018.1507755
- https://doi.org/10.1080/13102818.2018.1507755
- Author:
- Byungdoo Hwang; Seung-Shick Shin; Jun-Hui Song; Yung Hyun Choi; Wun-Jae Kim; Sung-Kwon Moon
- Source:
- Journal of nutritional biochemistry 2019 v.74 pp. 108230
- ISSN:
- 0955-2863
- Subject:
- angiogenesis; antineoplastic activity; carnosine; cell cycle; cell proliferation; cisplatin; cyclins; endothelial nitric oxide synthase; flow cytometry; mice; migratory behavior; mitogen-activated protein kinase; neoplasm cells; patients; therapeutics; transcription factor NF-kappa B; urinary bladder neoplasms; weight loss
- Abstract:
- ... Carnosine, a naturally occurring dipeptide, was recently reported to exhibit anticancer activity; however, the molecular mechanisms and regulators underlying its activity against tumor-associated angiogenesis remain unidentified. In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively. In addit ...
- DOI:
- 10.1016/j.jnutbio.2019.108230
- https://doi.org/10.1016/j.jnutbio.2019.108230
- Author:
- Yu-Jen Wu; Tzu-Rong Su; Guo-Fong Dai; Jui-Hsin Su; Chih-I Liu
- Source:
- Marine drugs 2019 v.17 no.5 pp. -
- ISSN:
- 1660-3397
- Subject:
- Sinularia; active ingredients; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell movement; corals; cytotoxicity; dose response; drug therapy; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; humans; mitochondria; mitogen-activated protein kinase; neoplasm cells; phosphatidylinositol 3-kinase; signal transduction; urinary bladder neoplasms
- Abstract:
- ... Flaccidoxide-13-acetate, an active compound isolated from cultured-type soft coral Sinularia gibberosa, has been shown to have inhibitory effects against invasion and cell migration of RT4 and T24 human bladder cancer cells. In our study, we used an 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT), colony formation assay, and flow cytometry to determine the mechanisms of the ...
- DOI:
- 10.3390/md17050287
- PubMed:
- 31086026
- PubMed Central:
- PMC6562797
- https://doi.org/10.3390/md17050287
- Author:
- Cheol Park; Hee-Jae Cha; Hyesook Lee; Hyun Hwang-Bo; Seon Yeong Ji; Min Yeong Kim; Su Hyun Hong; Jin-Woo Jeong; Min Ho Han; Sung Hyun Choi; Cheng-Yun Jin; Gi-Young Kim; Yung Hyun Choi
- Source:
- Antioxidants 2019 v.8 no.9 pp. -
- ISSN:
- 2076-3921
- Subject:
- NAD ADP-ribosyltransferase; antineoplastic activity; apoptosis; bladder; carcinoma; caspase-3; cell cycle checkpoints; cyclin-dependent kinase; cyclins; cysteine; cytochrome c; enzyme inhibitors; genistein; humans; mitochondria; mitosis; phosphatidylinositol 3-kinase; reactive oxygen species; signal transduction; urinary bladder neoplasms
- Abstract:
- ... We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis. Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulated the levels of p21WAF1/CIP1, cyclin-dependent kinase (Cdk) inhibitor, that was complexed with Cdc2 ...
- DOI:
- 10.3390/antiox8090327
- PubMed:
- 31438633
- PubMed Central:
- PMC6769882
- https://doi.org/10.3390/antiox8090327
- Author:
- Aleksandar Shkondrov; Ilina Krasteva; Iliana Ionkova; Pavlinka Popova; Yancho Zarev; Rositsa Mihaylova; Spiro Konstantinov
- Source:
- Biotechnology, biotechnological equipment 2019 v.33 no.1 pp. 1413-1418
- ISSN:
- 1314-3530
- Subject:
- Astragalus glycyphyllos; antineoplastic activity; biotechnology; callus; cytotoxicity; equipment; flavonoids; flora; humans; liquid chromatography; mass spectrometry; plant growth; traditional medicine; triterpenoid saponins; urinary bladder neoplasms; xenobiotics; Bulgaria
- Abstract:
- ... In the last decade the need of plant-derived cytotoxic compounds exceeds the possibilities for obtaining them from naturally grown sources. In vitro plant biotechnology offers a unique and often invaluable alternative for production of complex biologically active substances without harming the flora. Astragalus glycyphyllos L. (Fabaceae) is a plant native to Bulgaria that has been reported to cont ...
- DOI:
- 10.1080/13102818.2019.1671222
- https://doi.org/10.1080/13102818.2019.1671222
- Author:
- Qingdi Quentin Li; Iawen Hsu; Thomas Sanford; Reema Railkar; Navin Balaji; Carole Sourbier; Cathy Vocke; K. C. Balaji; Piyush K. Agarwal
- Source:
- Cellular and molecular life sciences 2018 v.75 no.5 pp. 939-963
- ISSN:
- 1420-682X
- Subject:
- antineoplastic activity; bladder; carcinoma; cell cycle checkpoints; cell lines; cyclins; databases; enzyme inhibitors; explants; flow cytometry; mice; models; neoplasm cells; protein kinases; small interfering RNA; urinary bladder neoplasms
- Abstract:
- ... The protein kinase D (PKD) family of proteins are important regulators of tumor growth, development, and progression. CRT0066101, an inhibitor of PKD, has antitumor activity in multiple types of carcinomas. However, the effect and mechanism of CRT0066101 in bladder cancer are not understood. In the present study, we show that CRT0066101 suppressed the proliferation and migration of four bladder ca ...
- DOI:
- 10.1007/s00018-017-2681-z
- https://doi.org/10.1007/s00018-017-2681-z
- Author:
- Huilong Wen; Zhong Wu; Huidong Hu; Yixiong Wu; Gang Yang; Jiajun Lu; Guang Yang; Gang Guo; Qirong Dong
- Source:
- Natural medicines 2018 v.72 no.1 pp. 57-63
- ISSN:
- 1340-3443
- Subject:
- Western blotting; Wolfiporia cocos; additive effect; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; cell proliferation; colorimetry; dose response; human cell lines; humans; lung neoplasms; neoplasm cells; osteosarcoma; phosphorylation; propidium; prostatic neoplasms; staining; triterpenoids; urinary bladder neoplasms
- Abstract:
- ... Pachymic acid (PA) is a lanostane type triterpenoid isolated from Poria cocos, which possesses an anti-tumor effect in breast cancer, prostate cancer, lung cancer, and bladder cancer cells. In this study, we investigated the effect of PA on the growth and apoptosis of human immortalized cell line (HOS) and primary osteosarcoma cells by a Cell Counting Kit-8 (CCK-8) and Annexin V and propidium iodi ...
- DOI:
- 10.1007/s11418-017-1117-2
- https://doi.org/10.1007/s11418-017-1117-2
- Author:
- Seung-Shick Shin; Yu-Jin Park; Byungdoo Hwang; Sung Lyea Park; Sang-Wook Han; Sung-Soo Park; Yung Hyun Choi; Wun-Jae Kim; Sung-Kwon Moon
- Source:
- Phytomedicine 2019 v.64 pp. 153069
- ISSN:
- 0944-7113
- Subject:
- Gleditsia triacanthos; acute toxicity; adverse effects; alkaloids; antineoplastic activity; apoptosis; autophagy; bioactive compounds; bladder; blood; cell proliferation; cisplatin; cyclin-dependent kinase; cyclins; cytotoxicity; dose response; flavonoids; flow cytometry; gel electrophoresis; in vivo studies; inhibitory concentration 50; interphase; metalloproteinases; mitogen-activated protein kinase; neoplasm cells; non-specific protein-tyrosine kinase; oral administration; saponins; solvents; staining; transcription factors; trees; urinary bladder neoplasms; weight loss
- Abstract:
- ... Numerous studies have focused on solvent extracts from locust trees (Gleditsia spp.), which contain diverse bioactive components including saponins, flavonoids, and alkaloids. However, because of the undefined nature of such phytochemicals, their clinical application as chemotherapeutic agents has often been limited.This study aimed to evaluate the anti-oncogenic activity of triacanthine, an alkal ...
- DOI:
- 10.1016/j.phymed.2019.153069
- https://doi.org/10.1016/j.phymed.2019.153069
- Author:
- J.W.M. Yuen; D.S.Y. Mak; E.S. Chan; M.D.I. Gohel; C.F. Ng
- Source:
- Journal of ethnopharmacology 2018 v.223 pp. 113-121
- ISSN:
- 0378-8741
- Subject:
- Ganoderma lucidum; Oriental traditional medicine; animal models; antineoplastic activity; bladder; body weight; catheters; chemoprevention; cytotoxicity; dose response; drugs; ethanol; immunotherapy; liquids; mice; urinary bladder neoplasms
- Abstract:
- ... Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities.To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer.Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter. Bacille Calme ...
- DOI:
- 10.1016/j.jep.2018.05.020
- https://doi.org/10.1016/j.jep.2018.05.020
- Author:
- Wenjuan Cao; Junqiang Tian; Chong Li; Yanjun Gao; Xingchen Liu; Jianzhong Lu; Yuhan Wang; Zhiping Wang; Robert S. Svatek; Ronald Rodriguez
- Source:
- Virology journal 2017 v.14 no.1 pp. 149
- ISSN:
- 1743-422X
- Subject:
- Adenoviridae; Enterovirus; antineoplastic activity; apoptosis; bladder; caspase-3; cisplatin; genes; interphase; neoplasm cells; protein synthesis; serotypes; urinary bladder neoplasms; viruses
- Abstract:
- ... BACKGROUND: Conditionally replicative oncolytic adenoviruses (CRAds) display significant anti-tumor effects. However, the traditional adenovirus of serotype 5 (Ad5) entering cancer cells via coxsackie virus and adenovirus receptor (CAR) can’t be utilized for bladder cancer with low expression of CAR, which limits the application of Ad5. METHODS: We utilized Ad5/F11p containing the chimeric fiber g ...
- DOI:
- 10.1186/s12985-017-0818-1
- PubMed:
- 28789701
- PubMed Central:
- PMC5549334
- https://doi.org/10.1186/s12985-017-0818-1
- Author:
- Besma Abbaoui; Christopher R. Lucas; Ken M. Riedl; Steven K. Clinton; Amir Mortazavi
- Source:
- Molecular nutrition & food research 2018 v.62 no.18 pp. e1800079
- ISSN:
- 1613-4125
- Subject:
- Brassicaceae; angiogenesis; antineoplastic activity; apoptosis; bioavailability; broccoli; cell cycle checkpoints; cell lines; chemical constituents of plants; diet; enzymatic hydrolysis; epigenetics; glucosinolates; guidelines; in vitro studies; in vivo studies; morbidity; mortality; neoplasm cells; risk reduction; stress response; sulforaphane; urinary bladder neoplasms; urine
- Abstract:
- ... Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Phytochemicals in cruciferous vegetables, such as glucosinolates, which are enzymatically hydrolyzed to bioactive isothi ...
- DOI:
- 10.1002/mnfr.201800079
- PubMed:
- 30079608
- PubMed Central:
- PMC6196731
- https://doi.org/10.1002/mnfr.201800079
- Author:
- Bapurao Surnar; Nagesh Kolishetti; Uttara Basu; Anis Ahmad; Erik Goka; Brian Marples; David Kolb; Marc E. Lippman; Shanta Dhar
- Source:
- Biochemistry 2018 v.57 no.46 pp. 6500-6513
- ISSN:
- 1520-4995
- Subject:
- DNA; DNA damage; adverse effects; antineoplastic activity; aspirin; cisplatin; drug therapy; in vitro studies; models; nausea; nephrotoxicity; neurotoxicity; patients; urinary bladder neoplasms
- Abstract:
- ... Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority o ...
- DOI:
- 10.1021/acs.biochem.8b00712
- https://doi.org/10.1021/acs.biochem.8b00712
- Author:
- Lei Huang; Bao-Long Li; Can-Xia He; Yao-Jie Zhao; Xiu-Li Yang; Bo Pang; Xiao-Hong Zhang; Yu-Juan Shan
- Source:
- Journal of functional foods 2018 v.41 pp. 118-126
- ISSN:
- 1756-4646
- Subject:
- DNA microarrays; antineoplastic activity; cadherins; epithelium; humans; metastasis; microRNA; non-coding RNA; repressor proteins; sulforaphane; transfection; urinary bladder neoplasms; vegetables; vimentin
- Abstract:
- ... Sulforaphane (SFN), one of the isothiocyanates, abundantly existed in quite a few of cruciferous vegetables and exhibits effective anticancer activities in our previous experiments. However, its effects on bladder cancer cell invasion and metastasis have only begun to be explored. Here, we investigated the effect of microRNA on bladder cancer cell invasion and the underlying molecular mechanism. A ...
- DOI:
- 10.1016/j.jff.2017.12.034
- https://doi.org/10.1016/j.jff.2017.12.034
- Author:
- Zhou Zhong; Zhong Cheng; Dongyuan Su; Ting Xu; Xiang Li; Fengbo Wu
- Source:
- RSC advances 2018 v.8 no.62 pp. 35395-35402
- ISSN:
- 2046-2069
- Subject:
- antineoplastic activity; autophagy; cell lines; cytotoxicity; doxorubicin; drug resistance; fluorescence microscopes; high performance liquid chromatography; lysosomes; micelles; models; nuclear magnetic resonance spectroscopy; pH; schiff bases; small interfering RNA; therapeutics; transmission electron microscopy; urinary bladder neoplasms
- Abstract:
- ... Herein, we describe a convenient approach for the preparation of a polymeric micelle using doxorubicin (DOX) conjugated trimethyl-chitosan (TMC) with Beclin-1 siRNA (Si-Beclin1/DOX-TMC). This micelle displayed a potent capacity for autophagy inhibition and reversed drug-resistance to DOX in BIU-87/ADR cell lines. The Si-Beclin1/DOX-TMC micelle was highly cytotoxic to both drug-sensitive BIU-87 and ...
- DOI:
- 10.1039/c8ra06548a
- https://doi.org/10.1039/c8ra06548a
- Author:
- Yu-Lin Kao; Yi-Ming Kuo; Yi-Ru Lee; Wen-Jung Chen; Yung-Shu Lee; Huei-Jane Lee
- Source:
- Journal of functional foods 2017 v.36 pp. 1-8
- ISSN:
- 1756-4646
- Subject:
- animal models; antineoplastic activity; apoptosis; bladder; carcinoma; cell cycle checkpoints; cyclins; immunohistochemistry; neoplasm cells; polyphenols; proliferating cell nuclear antigen; rats; ultrasonography; urinary bladder neoplasms
- Abstract:
- ... Apple polyphenol (AP) was found to possess the potential to prevent cancers. Previously, our study showed AP can trigger bladder transitional carcinoma cells to apoptosis and regulate its cell cycle. This study is aimed to evaluate the anticancer effect of AP in urinary bladder carcinoma in vivo. A rat model of bladder cancer was induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (OH-BBN). Tumours ...
- DOI:
- 10.1016/j.jff.2017.06.019
- https://doi.org/10.1016/j.jff.2017.06.019
- Author:
- Dengdian Wang; Xiaochuan Kong; Yuan Li; Weiwei Qian; Jiaxing Ma; Daming Wang; Dexin Yu; Caiyun Zhong
- Source:
- Biochemical and biophysical research communications 2017 v.493 pp. 521-527
- ISSN:
- 0006-291X
- Subject:
- Western blotting; antineoplastic activity; apoptosis; cell cycle; cell proliferation; chemoprevention; curcumin; fluorescent antibody technique; humans; phytopharmaceuticals; quantitative polymerase chain reaction; staining; stem cells; urinary bladder neoplasms
- Abstract:
- ... Cancer stem cells (CSCs) is responsible for the recurrence of human cancers. Thus, targeting CSCs is considered to be a valid way for human cancer treatment. Curcumin is a major component of phytochemicals that exerts potent anticancer activities. However, the effect of curcumin on bladder cancer stem cells (BCSCs) remains to be elucidated. In this study, we investigated the mechanism of curcumin ...
- DOI:
- 10.1016/j.bbrc.2017.08.158
- https://doi.org/10.1016/j.bbrc.2017.08.158
- Author:
- Paolino Ninfali; Elena Antonini; Alessandra Frati; Emanuele‐Salvatore Scarpa
- Source:
- Phytotherapy research 2017 v.31 no.6 pp. 871-884
- ISSN:
- 0951-418X
- Subject:
- Beta vulgaris subsp. vulgaris; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apigenin; apoptosis; beets; betacyanins; betalains; breasts; colon; gene expression regulation; genes; human health; hypoxia; liver; multiple drug resistance; neoplasm cells; phytopharmaceuticals; toxicity; urinary bladder neoplasms; vascular endothelial growth factors
- Abstract:
- ... The green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. rubra L.) contain phytochemicals that have beneficial effects on human health. Specifically, the green beet contains apigenin, vitexin, vitexin‐2‐O‐xyloside and vitexin‐2‐O‐rhamnoside, while the red beetroot is a source of betaxanthins and betacyanins. These phytochemicals show considerable antioxidant activity, as wel ...
- DOI:
- 10.1002/ptr.5819
- https://doi.org/10.1002/ptr.5819
- Author:
- Yiying WuThese authors contributed equally to this article.; Xing Zhang; Zhengzhao Li; Haibiao Yan; Jian Qin; Tianyu Li
- Source:
- Food & function 2017 v.8 no.3 pp. 1061-1066
- ISSN:
- 2042-650X
- Subject:
- Astragalus membranaceus; Western blotting; anticarcinogenic activity; antineoplastic activity; apoptosis; cell proliferation; dose response; formononetin; humans; neoplasm cells; protein content; quantitative polymerase chain reaction; toxicity testing; urinary bladder neoplasms
- Abstract:
- ... The isoflavone formononetin is the main active component of Astragalus membranaceus and possesses anti-tumorigenic properties. However, the role of formononetin in human bladder cancer (BCa) has not been fully elucidated. The aim of the present study was to investigate the anti-tumor effects of formononetin on BCa cells and its potential molecular mechanism. T24 cells were treated with different c ...
- DOI:
- 10.1039/c6fo01535b
- https://doi.org/10.1039/c6fo01535b
- Author:
- Dong Chen; Shaopeng Sun; Dawei Cai; Guangqi Kong
- Source:
- International journal of biological macromolecules 2017 pp. -
- ISSN:
- 0141-8130
- Subject:
- Ginkgo biloba; antineoplastic activity; apoptosis; cell viability; humans; leaves; mechanism of action; polysaccharides; protein synthesis; selenium; urinary bladder neoplasms
- Abstract:
- ... In the present study, a selenium (Se)-containing polysaccharide (Se-GBLP) was isolated and purified from the leaves of Ginkgo biloba L. Se-GBLP was further evaluated for its antitumor activity against human bladder cancer T24 cells together with the possible mechanism of action. Our results showed that treatment of T24 cells with Se-GBLP (50, 100 and 200μg/ml) for 48h significantly inhibited cell ...
- DOI:
- 10.1016/j.ijbiomac.2017.03.033
- https://doi.org/10.1016/j.ijbiomac.2017.03.033
- Author:
- Angela Patricia Moreno-Londoño; Claudia Bello-Alvarez; José Pedraza-Chaverri
- Source:
- Food and chemical toxicology 2017 v.109 pp. 143-154
- ISSN:
- 0278-6915
- Subject:
- anti-inflammatory activity; antineoplastic activity; bilirubin; carbon monoxide; caspase-3; cell death; chalcone; cisplatin; death; dose response; heme oxygenase (biliverdin-producing); kidneys; nephrotoxicity; protective effect; reactive oxygen species; toxicology; urinary bladder neoplasms
- Abstract:
- ... Cisplatin is an effective antineoplastic agent widely used in the treatment of solid tumors, however, it induces nephrotoxicity. Cisplatin-induced nephrotoxicity is associated with increased reactive oxygen species (ROS) production and decreased antioxidant system defense in kidney. Isoliquiritigenin (IsoLQ) is a chalcone, which is characterized by its antioxidant and antiinflammatory properties. ...
- DOI:
- 10.1016/j.fct.2017.08.047
- https://doi.org/10.1016/j.fct.2017.08.047
- Author:
- Chongshan Wang; Qiongren Wang; Xiezhao Li; Zhong Jin; Peng Xu; Naijin Xu; Abai Xu; Yawen Xu; Shaobo Zheng; Junxia Zheng; Chunxiao Liu; Peng Huang
- Source:
- Biochemical and biophysical research communications 2017 v.483 pp. 197-202
- ISSN:
- 0006-291X
- Subject:
- Amaryllidaceae; antineoplastic activity; apoptosis; caspase-3; humans; in vivo studies; lycorine; mice; neoplasm cells; patients; urinary bladder neoplasms
- Abstract:
- ... Lycorine, an alkaloid extracted from Amaryllidaceae genera, exhibits antitumor activities against several human solid-tumor and leukemia cells with extensive influence on various cell signaling molecules. However, the effect of lycorine on bladder cancer has not yet been investigated. In this study, we demonstrated that lycorine induced apoptosis in human bladder cancer T24 cells, an effect that i ...
- DOI:
- 10.1016/j.bbrc.2016.12.168
- https://doi.org/10.1016/j.bbrc.2016.12.168
- Author:
- Di Liu; Xin Yao Qiu; Xi Wu; Dian Xing Hu; Chun Yang Li; Shang Bin Yu; Feng Pan; Xiao Qian Chen
- Source:
- Biochemical and biophysical research communications 2017 v.494 no.1-2 pp. 165-172
- ISSN:
- 0006-291X
- Subject:
- actin; alkaloids; antineoplastic activity; antineoplastic agents; beta catenin; cadherins; cell proliferation; cytoskeleton; epithelium; in vivo studies; neoplasm cells; pseudopodia; reactive oxygen species; therapeutics; urinary bladder neoplasms
- Abstract:
- ... Piperlongumine (PL), a natural alkaloid isolated from longer pepper plants, is recently found to be a potent selective anti-cancer compound. We first tested its anti-cancer effects on bladder cancer, the fifth most common and aggressive cancer worldwide, to further explore the therapeutic spectrum and molecular mechanisms of PL. PL significantly suppressed bladder cancer cell proliferation, the tr ...
- DOI:
- 10.1016/j.bbrc.2017.10.061
- https://doi.org/10.1016/j.bbrc.2017.10.061
- Author:
- Yi Li; Jia-ming Wen; Chuan-jun Du; Su-min Hu; Jia-xi Chen; Shi-geng Zhang; Nan Zhang; Feng Gao; Shao-jiang Li; Xia-wa Mao; Hiroshi Miyamoto; Ke-feng Ding
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; cell proliferation; cysteine; cytochrome c; mitogen-activated protein kinase; neoplasm cells; reactive oxygen species; thymol; urinary bladder neoplasms
- Abstract:
- ... Thymol is a phenolic compound with various pharmacological activities such as anti-inflammatory, anti-bacterial and anti-tumor effects. However, the effect of thymol on bladder cancer cell growth is still elusive. The purpose of this study is to investigate the efficacy of thymol in bladder cancer cells and its underlying mechanism. Thymol inhibited bladder cancer cell proliferation in a dose and ...
- DOI:
- 10.1016/j.bbrc.2017.04.009
- https://doi.org/10.1016/j.bbrc.2017.04.009
- Author:
- João Pinto da Costa; Virginia Carvalhais; Francisco Amado; Artur Silva; Rita Nogueira-Ferreira; Rita Ferreira; Luísa Helguero; Rui Vitorino
- Source:
- Peptides 2015 v.71 pp. 170-178
- ISSN:
- 0196-9781
- Subject:
- adherens junctions; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; breasts; cadherins; cell adhesion; cell lines; colon; drug therapy; humans; microscopy; neoplasm cells; osteosarcoma; peptides; population growth; prostate gland; protein synthesis; tissues; toxicity; urinary bladder neoplasms
- Abstract:
- ... Chemotherapy continues to be the standard treatment for advanced or metastasized cancer. However, commonly used chemotherapeutic agents may induce damage in healthy cells and tissues. Thus, in recent years, there has been an increased focus on the development of new, efficient anticancer drugs exhibiting low toxicity and that are not affected by mechanisms of chemoresistance.In the present work, w ...
- DOI:
- 10.1016/j.peptides.2015.07.014
- https://doi.org/10.1016/j.peptides.2015.07.014
- Author:
- Li-Jun Zhang; Xiang-Hua Zhang; Ping-Yong Liao; Jing-Jian Sun; Li Wang; Yi-Jia Yan; Zhi-Long Chen
- Source:
- Journal of photochemistry and photobiology 2016 v.163 pp. 224-231
- ISSN:
- 1011-1344
- Subject:
- absorption; antineoplastic activity; fluorescence; histopathology; humans; irradiation; mice; neoplasm cells; phototoxicity; physicochemical properties; porphyrins; spectroscopy; therapeutics; urinary bladder neoplasms
- Abstract:
- ... Photodynamic therapy is a minimally invasive and promising new method in cancer treatment and has attracted considerable attention in recent years. An ideal photosensitizer is a crucial element to photodynamic therapy. In the present paper, a novel porphyrin derivative, 5, 10, 15, 20-tetrakis (5-(pyrrolidin-1-yl) pentyl) porphin (TPPP) was synthesized. Its spectroscopic and physicochemical propert ...
- DOI:
- 10.1016/j.jphotobiol.2016.08.044
- https://doi.org/10.1016/j.jphotobiol.2016.08.044
- Author:
- Claudia Ceci; Lucio Tentori; Maria Grazia Atzori; Pedro M. Lacal; Elena Bonanno; Manuel Scimeca; Rosella Cicconi; Maurizio Mattei; Maria Gabriella de Martino; Giuseppe Vespasiani; Roberto Miano; Grazia Graziani
- Source:
- Nutrients 2016 v.8 no.11 pp. -
- ISSN:
- 2072-6643
- Subject:
- angiogenesis; antineoplastic activity; chemotaxis; disease progression; ellagic acid; extracellular matrix; grapes; green tea; human cell lines; humans; hydrolysis; in vivo studies; ligands; mice; mitomycin; models; neoplasm cells; nuts; pomegranates; programmed cell death; small fruits; therapeutics; urinary bladder neoplasms; vascular endothelial growth factor A; vascular endothelial growth factor receptor-2
- Abstract:
- ... Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. Previous studies have reported the antitumor properties of EA mainly using in vitro models. No data are available about EA influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular endothe ...
- DOI:
- 10.3390/nu8110744
- PubMed:
- 27879653
- PubMed Central:
- PMC5133127
- https://doi.org/10.3390/nu8110744
- Author:
- Samuel Kaiser; Ânderson Ramos Carvalho; Vanessa Pittol; Fabrícia Dietrich; Fabiana Manica; Michel Mansur Machado; Luis Flávio Souza de Oliveira; Ana Maria Oliveira Battastini; George González Ortega
- Source:
- Journal of ethnopharmacology 2016 v.189 pp. 90-98
- ISSN:
- 0378-8741
- Subject:
- DNA; Uncaria tomentosa; alkaloids; antineoplastic activity; bark; chemotypes; claws; cytotoxicity; freeze drying; genotoxicity; glioblastoma; human cell lines; ion exchange; isomerization; leaves; leukocytes; mutagens; neoplasm cells; rain forests; traditional medicine; urinary bladder neoplasms; vines
- Abstract:
- ... Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) or cat's claw is a climber vine from the South American rainforest used in folk medicine for cancer treatment. Its antitumor activity has been mostly ascribed to pentacyclic oxindole alkaloids (POA) from stem bark and leaves while the activity of tetracyclic oxindole alkaloids (TOA) remains unknown. In recent times, the occurrence ...
- DOI:
- 10.1016/j.jep.2016.05.026
- https://doi.org/10.1016/j.jep.2016.05.026
- Author:
- Zhenhua Chen; Ting Yu; Bangfen Zhou; Jinhuan Wei; Yong Fang; Jun Lu; Ling Guo; Wei Chen; Zhi-Ping Liu; Junhang Luo
- Source:
- Biomaterials 2016 v.81 pp. 125-134
- ISSN:
- 0142-9612
- Subject:
- ambient temperature; antineoplastic activity; biocompatibility; catechin; cell growth; drug therapy; gene therapy; green tea; magnesium; models; nanocomposites; nanoparticles; oncogenes; rats; signal transduction; small interfering RNA; translation (genetics); urinary bladder neoplasms
- Abstract:
- ... Emerging evidence indicates that combination of two or more therapeutic strategies can synergistically enhance antitumor activity in cancer therapy. Here, we established a green method of generating nanocomposite particles that can be fabricated using catechin, a natural anti-cancer compound from green tea, and Mg2+ in an easy one-step approach at room temperature. We show that Mg(II)-Catechin nan ...
- DOI:
- 10.1016/j.biomaterials.2015.11.022
- https://doi.org/10.1016/j.biomaterials.2015.11.022
54. Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer
- Author:
- X.C. Peng; F.M. Gong; Y. Chen; M. Qiu; K. Cheng; J. Tang; J. Ge; N. Chen; H. Zeng; J.Y. Liu
- Source:
- Journal of proteomics 2016 v.132 pp. 85-92
- ISSN:
- 1874-3919
- Subject:
- RNA interference; antineoplastic activity; apoptosis; biomarkers; calcium; cell proliferation; cluster analysis; glycolysis; immunohistochemistry; pentose phosphate cycle; protein synthesis; proteins; proteomics; tissues; two-dimensional gel electrophoresis; urinary bladder neoplasms
- Abstract:
- ... Urothelial bladder cancer (UBC) is a major global health problem. There have been no major advances for the treatment of UBC in the last 30years. In this study, we attempted to discover novel candidate therapeutic biomarkers for UBC. We utilized a two-dimensional polyacrylamide gel electrophoresis (2-DE) and ESI-Q-TOF MS/MS-based proteomic method to compare and identify differentially expressed pr ...
- DOI:
- 10.1016/j.jprot.2015.11.027
- https://doi.org/10.1016/j.jprot.2015.11.027
- Author:
- Tomohiro Nakano; Yuriko Saiki; Chiharu Kudo; Akiyoshi Hirayama; Yasuhiko Mizuguchi; Sho Fujiwara; Tomoyoshi Soga; Makoto Sunamura; Nobutoshi Matsumura; Fuyuhiko Motoi; Michiaki Unno; Akira Horii
- Source:
- Biochemical and biophysical research communications 2015 v.464 no.4 pp. 1084-1089
- ISSN:
- 0006-291X
- Subject:
- alleles; antineoplastic activity; gall bladder; loss-of-function mutation; lung neoplasms; missense mutation; pancreatic neoplasms; phosphorylation; stomach neoplasms; urinary bladder neoplasms; volunteers
- Abstract:
- ... The anti-tumor activity of gemcitabine (GEM) has been clinically proven in several solid tumors, including pancreatic cancer, biliary tract cancer, urinary bladder cancer, and non-small cell lung cancer. However, problems remain with issues such as acquisition of chemoresistance against GEM. GEM is activated after phosphorylation by deoxycytidine kinase (DCK) inside of the cell; thus, DCK inactiva ...
- DOI:
- 10.1016/j.bbrc.2015.07.080
- https://doi.org/10.1016/j.bbrc.2015.07.080
- Author:
- Hye Young Park; Il-Whan Choi; Gi-Young Kim; Byung Woo Kim; Wun-Jae Kim; Yung Hyun Choi
- Source:
- Revista Brasileira de Farmacognosia 2015 v.25 no.3 pp. 246-251
- ISSN:
- 0102-695X
- Subject:
- Phaeophyceae; algae; antineoplastic activity; apoptosis; cell cycle; cyclins; dephosphorylation; dose response; flow cytometry; fucoidan; humans; neoplasm cells; phosphorylation; transcription factors; urinary bladder neoplasms
- Abstract:
- ... Fucoidan, a sulfated polysaccharide found in marine algae and brown seaweeds, has been shown to inhibit the in vitro growth of human cancer cells. This study was conducted in cultured human bladder cancer EJ cells to elucidate the possible mechanisms by which fucoidan exerts its anti-proliferative activity, which until now has remained poorly understood. Fucoidan treatment of EJ cells resulted in ...
- DOI:
- 10.1016/j.bjp.2015.03.011
- https://doi.org/10.1016/j.bjp.2015.03.011
- Author:
- Olga Antonova; Draga Toncheva; Hans-Georg Rammensee; Matthias Floetenmeyer; Stefan Stevanovic; Pavlina Dolashka
- Source:
- Zeitschrift für Naturforschung 2014 v.69 no.7-8 pp. 325-334
- ISSN:
- 1865-7125
- Subject:
- Helix aspersa; antineoplastic activity; cytotoxicity; doxorubicin; endotoxins; human cell lines; keyhole limpet hemocyanin; leukemia; lymphoma; mitomycin; ovarian neoplasms; prostatic neoplasms; snails; urinary bladder neoplasms
- Abstract:
- ... As an extension of our studies on the antitumour properties of various hemocyanins, we sought to compare the antiproliferative effects of hemocyanins derived from two snail species: Helix lucorum (HlH) and Helix aspersa (HaH). This is the first report on the antitumour effects of HaH. We hypothesized that HaH has antitumour effects not only against bladder cancer, as previously shown with other he ...
- DOI:
- 10.5560/znc.2013-0148
- https://doi.org/10.5560/znc.2013-0148
- Author:
- Xuan Yuan; Tao Li; Erlong Xiao; Hong Zhao; Yongqian Li; Shengjun Fu; Lu Gan; Zhenhua Wang; Qiusheng Zheng; Zhiping Wang
- Source:
- Food and chemical toxicology 2014 v.65 pp. 242-251
- ISSN:
- 0278-6915
- Subject:
- NAD ADP-ribosyltransferase; antineoplastic activity; apoptosis; caspase-3; cell division; chemoprevention; cyclin-dependent kinase; cyclins; humans; in vitro studies; interphase; messenger RNA; mice; models; neoplasm cells; pro-apoptotic proteins; therapeutics; toxicology; urinary bladder neoplasms
- Abstract:
- ... To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. Exposure of T24 or EJ cells to LCB significantly inhibited cell lines proliferation in a concentration-dependent and time-dependent manner, and resulted in S phase ...
- DOI:
- 10.1016/j.fct.2013.12.030
- https://doi.org/10.1016/j.fct.2013.12.030
- Author:
- Takashi Nakamura; Masafumi Fukiage; Yoshiteru Suzuki; Ikuya Yano; Jun Miyazaki; Hiroyuki Nishiyama; Hideyuki Akaza; Hideyoshi Harashima
- Source:
- Journal of controlled release 2014 v.196 pp. 161-167
- ISSN:
- 0168-3659
- Subject:
- antineoplastic activity; dendritic cells; encapsulation; mice; models; nanoparticles; neoplasm cells; skeleton; therapeutics; urinary bladder neoplasms; water solubility
- Abstract:
- ... We previously reported on the development of a water soluble formulation of the cell wall skeleton of BCG (BCG-CWS), a major immune active center of BCG, by encapsulating it into a nanoparticle (CWS-NP). The CWS-NP allowed us to clarify the machinery associated with the BCG mediated anti-bladder tumor effect, especially the roles of bladder cancer cells and dendritic cells (DCs) in the initial ste ...
- DOI:
- 10.1016/j.jconrel.2014.10.007
- https://doi.org/10.1016/j.jconrel.2014.10.007
- Author:
- Ganesan Padmavathi; Sivakumar Raju Rathnakaram; Javadi Monisha; Devivasha Bordoloi; Nand Kishor Roy; Ajaikumar B. Kunnumakkara
- Source:
- Phytomedicine 2015 v.22 pp. 1163-1171
- ISSN:
- 0944-7113
- Subject:
- CXCR4 receptor; adverse effects; angiogenesis; antineoplastic activity; apoptosis; chemoprevention; chemosensitization; drug therapy; gene expression; liver; metastasis; mitogen-activated protein kinase; neoplasm cells; transcription factor NF-kappa B; urinary bladder neoplasms; vascular endothelial growth factors
- Abstract:
- ... Despite the major advances made in the field of cancer biology, it still remains one of the most fatal diseases in the world. It is now well established that natural products are safe and efficacious and have high potential in the prevention and treatment of different diseases including cancer. Butein is one such compound which is now found to have anti-cancer properties against various malignanci ...
- DOI:
- 10.1016/j.phymed.2015.08.015
- https://doi.org/10.1016/j.phymed.2015.08.015
- Author:
- Fabrícia Dietrich; Samuel Kaiser; Liliana Rockenbach; Fabrício Figueiró; Letícia Scussel Bergamin; Fernanda Monte da Cunha; Fernanda Bueno Morrone; George González Ortega; Ana Maria Oliveira Battastini
- Source:
- Food and chemical toxicology 2014 v.67 pp. 222-229
- ISSN:
- 0278-6915
- Subject:
- Uncaria tomentosa; adjuvants; antineoplastic activity; apoptosis; bark; caspase-3; cell cycle checkpoints; cell proliferation; glycosides; human growth; humans; mitogen-activated protein kinase; researchers; therapeutics; toxicity; toxicology; traditional medicine; transcription factor NF-kappa B; urinary bladder neoplasms; viability
- Abstract:
- ... Bladder cancer is the second most prevalent malignancy in the genitourinary tract and remains a therapeutic challenge. In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria tomentosa is noteworthy because the bark and root of this species are widely used in traditional medicine and in adjuvant therapy for the treatment of ...
- DOI:
- 10.1016/j.fct.2014.02.037
- https://doi.org/10.1016/j.fct.2014.02.037
- Author:
- Takashi Nakamura; Masafumi Fukiage; Megumi Higuchi; Akihiro Nakaya; Ikuya Yano; Jun Miyazaki; Hiroyuki Nishiyama; Hideyuki Akaza; Toshihiro Ito; Hiroyuki Hosokawa; Toshinori Nakayama; Hideyoshi Harashima
- Source:
- Journal of controlled release 2014 v.176 pp. 44-53
- ISSN:
- 0168-3659
- Subject:
- Mycobacterium bovis; T-lymphocytes; animal models; antineoplastic activity; antineoplastic agents; cell walls; humans; lipids; mice; molecular weight; nanoparticles; therapeutics; urinary bladder neoplasms
- Abstract:
- ... The Mycobacterium bovis Bacille Calmette–Guerin cell wall skeleton (BCG-CWS) could be used to replace live BCG as a bladder cancer drug. However, because BCG-CWS is poorly soluble, has a strong-negative charge, very high molecular weight and heterogeneity in size of tens of μm, it cannot be used in such an application. We report herein on the development of a novel packaging method that permits BC ...
- DOI:
- 10.1016/j.jconrel.2013.12.027
- https://doi.org/10.1016/j.jconrel.2013.12.027
- Author:
- Lee, Jae K.; Havaleshko, Dmytro M.; Cho, HyungJun; Weinstein, John N.; Kaldjian, Eric P.; Karpovich, John; Grimshaw, Andrew; Theodorescu, Dan
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.32 pp. 13086-13091
- ISSN:
- 0027-8424
- Subject:
- algorithms; antineoplastic activity; breast neoplasms; chemical compounds; databases; drug therapy; drugs; human cell lines; humans; microarray technology; patients; prediction; screening; translation (genetics); urinary bladder neoplasms; United States
- Abstract:
- ... The U.S. National Cancer Institute has used a panel of 60 diverse human cancer cell lines (the NCI-60) to screen >100,000 chemical compounds for anticancer activity. However, not all important cancer types are included in the panel, nor are drug responses of the panel predictive of clinical efficacy in patients. We asked, therefore, whether it would be possible to extrapolate from that rich databa ...
- DOI:
- 10.1073/pnas.0610292104
- PubMed:
- 17666531
- PubMed Central:
- PMC1941805
- https://doi.org/10.1073/pnas.0610292104