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1. Functional characterization of a histone H2A derived antimicrobial peptide HARRIOTTIN-1 from sicklefin chimaera, Neoharriotta pinnata

Author:
Naveen Sathyan; S. Muhammed Musthafa; M.V. Anju; K. Archana; P.P. Athira; Namitha Prathap; E.R. Chaithanya; P. Priyaja; I.S. Bright Singh; Rosamma Philip
Source:
Developmental and comparative immunology 2023 v.138 pp. 104554
ISSN:
0145-305X
Subject:
antibacterial properties; antimicrobial peptides; antineoplastic activity; chimerism; computer simulation; genes; histones; innate immunity; models; recombinant peptides
Abstract:
... Antimicrobial peptides (AMPs) are gene encoded short peptides which play an important role in the innate immunity of almost all living organisms ranging from bacteria to mammals. Histones play a very important role in defense as precursors to bioactive peptides. The present study is an attempt to decipher the antimicrobial activity of a histone H2A derived peptide, Harriottin-1 from sicklefin chim ...
DOI:
10.1016/j.dci.2022.104554

2. Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff

Author:
Siyuan Su; Xiang Ding; Yiling Hou; Binbin Liu; Zhouhe Du; Junfeng Liu
Source:
Food science and human wellness 2023 v.12 no.2 pp. 647-661
ISSN:
2213-4530
Subject:
Hexagonia tenuis; antineoplastic activity; food science; galactose; glucose; humans; immunoglobulin G; immunomodulators; molecular weight; phagocytosis; polysaccharides; secretion; transcriptome; water solubility
Abstract:
... A new water-soluble heteropolysaccharide with a molecular weight of 15 kDa was isolated from the fruiting bodies of Boletus reticulatus Schaeff. Structural characterization results revealed that B. reticulatus Schaeff polysaccharide (BRS-X) had a backbone of 1,6-linked α-D-galactose and 1,2,6-linked α-D-galactose which branches were mainly composed of a terminal 4-linked β-D-glucose and the ratio ...
DOI:
10.1016/j.fshw.2022.07.067

3. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

Author:
Haibo Zhang; Jun-Koo Yi; Hai Huang; Sijun Park; Wookbong Kwon; Eungyung Kim; Soyoung Jang; Si-Yong Kim; Seong-kyoon Choi; Duhak Yoon; Sung-Hyun Kim; Kangdong Liu; Zigang Dong; Zae Young Ryoo; Myoung Ok Kim
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 396-407
ISSN:
1226-8453
Subject:
Panax; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; cell proliferation; colorectal neoplasms; morbidity; mortality; neoplasm cells; research; toxicity; transfection; xenotransplantation
Abstract:
... Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, and western ...
DOI:
10.1016/j.jgr.2021.07.004

4. 2D Copper(II) Metalated Metal–Organic Framework Nanocomplexes for Dual-enhanced Photodynamic Therapy and Amplified Antitumor Immunity

Author:
Zixuan Chen; Yafeng Wu; Zhipeng Yao; Juan Su; Zhi Wang; Hongping Xia; Songqin Liu
Source:
ACS applied materials & interfaces 2022 v.14 no.39 pp. 44199-44210
ISSN:
1944-8252
Subject:
adsorption; antineoplastic activity; cell death; coordination polymers; cytotoxicity; folic acid; immune response; immunosuppression; immunotherapy; macrophages; nanomedicine; nanoparticles; nanosheets; neoplasms; oxidative stress; phenotype; photochemotherapy; platinum
Abstract:
... The immunosuppressive tumor microenvironment (TME) poses tremendous challenges for efficient immunotherapy. Smart nanomedicine is designed to modulate immunosuppressive TMEs based on the combination of dual-enhanced photodynamic therapy (PDT) triggered immunogenic cell death (ICD) and relieved hypoxic microenvironment. Copper(II) metalated metal–organic framework nanosheets (Cu-TCPP(Al)) are the f ...
DOI:
10.1021/acsami.2c12990

5. 3D printed tablets containing oxaliplatin loaded alginate nanoparticles for colon cancer targeted delivery. An in vitro/in vivo study

Author:
Seyedeh Zahra Mirdamadian; Jaleh Varshosaz; Mohsen Minaiyan; Azade Taheri
Source:
International journal of biological macromolecules 2022 v.205 pp. 90-109
ISSN:
0141-8130
Subject:
alginates; antineoplastic activity; cancer therapy; colorectal neoplasms; drugs; extrusion; intestines; intravenous injection; oral administration; printers; stomach; three-dimensional printing
Abstract:
... This study aimed to develop a colon-targeted tablet of oxaliplatin (OP) using the combination of nanotechnology and fused deposition modeling (FDM) 3D printing to improve its antitumor activity, tumor targetability, and safety profile. Eudragit L100-55 filament containing OP loaded alginate nanoparticles (OP-NPs) were fabricated using hot-melt extrusion method and printed by an FDM printer to 3D p ...
DOI:
10.1016/j.ijbiomac.2022.02.080

6. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

Author:
Guoliang Dai; Dong Wang; Shitang Ma; Shengwei Hong; Kang Ding; Xiying Tan; Wenzheng Ju
Source:
Phytomedicine 2022 v.102 pp. 154149
ISSN:
0944-7113
Subject:
Rheum palmatum; Western blotting; antineoplastic activity; carcinogenesis; cell proliferation; colorectal neoplasms; data collection; databases; emodin; gene expression regulation; immunohistochemistry; ingredients; mice; mortality; secretion; therapeutics; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2
Abstract:
... Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown. The present study is aimed to explore the potential anti-tumor effects of emodin against CRC ...
DOI:
10.1016/j.phymed.2022.154149

7. An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy

Author:
Yaqi Wang; Xiaohong Pan; Tao Dai; Le Wang; Haixing Shi; Huanhuan Wang; Zhuo Chen
Source:
Biomaterials science 2022 v.10 no.17 pp. 4866-4875
ISSN:
2047-4849
Subject:
antineoplastic activity; biocompatible materials; biotin; carboxylic acids; electron transfer; fluorescence; neoplasms; nitrobenzoic acids; nitroreductases; photochemotherapy; photosensitivity; photosensitizing agents; photostability; toluene
Abstract:
... Fluorescence quenching occurs in most nitroaromatic compounds due to photoinduced electron transfer (PET) effects, limiting their use as image-guided photosensitizers for anticancer photodynamic therapy (PDT) or as probes for nitroreductase in hypoxic cells. Herein, we developed a tumor-targeting aggregation-induced emission photosensitizer (AIE-PS), Biotin-TTVBA, by binding TTVBA (a nitrobenzoic ...
DOI:
10.1039/d2bm00704e

8. Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Author:
Chunyu Jiang; Mengyue Yang; Chunxue Zhao; Fangshen Liu; Hangao Yang; Zhanlin Li; Tong Han; Bin Lin; Dahong Li; Huiming Hua
Source:
Phytochemistry 2022 v.199 pp. 113187
ISSN:
0031-9422
Subject:
Cephalotaxus; antineoplastic activity; apoptosis; circular dichroism spectroscopy; cytotoxicity; diterpenoids; humans; neoplasm cells; plant biochemistry; spectral analysis
Abstract:
... Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglypti ...
DOI:
10.1016/j.phytochem.2022.113187

9. Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization

Author:
Yunfei Hu; Li Chen; Canlin Zou; Jiangtao He; Luanqi Feng; Jia-Qiang Wu; Wen-Hua Chen; Jinhui Hu
Source:
Organic letters 2022 v.24 no.28 pp. 5137-5142
ISSN:
1523-7052
Subject:
antineoplastic activity; electrochemistry; isothiocyanates; pyridines
Abstract:
... An efficient, one-pot approach has been established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochemically induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allows for the formation of C–N bonds under simple conditions without transition metals or external oxidants. The practicability of thi ...
DOI:
10.1021/acs.orglett.2c01968

10. Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

Author:
Yemeng Tang; Yanmao Wang; Xian Wang; Zhucheng Zhao; Haijian Cai; Mengyao Xie; Xintong Jiang; Luyao Zhang; Jiayun Cheng; Lehe Yang; Liangxing Wang; Chengguang Zhao; Xiaoying Huang
Source:
Phytomedicine 2022 v.101 pp. 154109
ISSN:
0944-7113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell movement; drug resistance; epidermal growth factor receptors; flow cytometry; fluorescent antibody technique; humans; lung neoplasms; mechanism of action; models; morbidity; phosphorylation; proteome; signal transduction; survival rate; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is one of the most common types of malignant tumor. It has one of the highest morbidity and mortality rates worldwide, and approximately 85% of cases are non-small cell lung cancer (NSCLC). Clinically, several EGFR inhibitors have been used to treat NSCLC, but resistance can develop. Studies have shown that cross talk between signal transducer and activator of transcription 3 (STAT3) a ...
DOI:
10.1016/j.phymed.2022.154109

11. Acid-sensitive charge-reversal co-assembled polyurethane nanomicelles as drug delivery carriers

Author:
Jingyi Liu; Zhoutong Dai; Yu Zhou; Wangwang Tao; Hongxiang Chen; Zuyi Zhao; Xinghua Liao
Source:
Colloids and surfaces 2022 v.209 pp. 112203
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; blood; cytotoxicity; drugs; electrostatic interactions; gel chromatography; micelles; neoplasms; nuclear magnetic resonance spectroscopy; pH; polyurethanes
Abstract:
... In order to obtain drug delivery carriers with good stability in blood and high cellular uptake efficiency, carboxyl groups and tertiary amine groups were respectively introduced into polyurethane to synthesize two kinds of amphiphilic polyurethanes with opposite charges (PUC and PUN). Their structures were characterized by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance ...
DOI:
10.1016/j.colsurfb.2021.112203

12. Activation of aryl hydrocarbon receptor signaling by gallic acid suppresses progression of human breast cancer in vitro and in vivo

Author:
Hamza Hanieh; Hairul-Islam M. Ibrahim; Maged Mohammed; Osama I. Alwassil; Mohammad H. Abukhalil; Mahdi Farhan
Source:
Phytomedicine 2022 v.96 pp. 153817
ISSN:
0944-7113
Subject:
B-cell lymphoma; antineoplastic activity; apoptosis; aryl hydrocarbon receptors; breast neoplasms; cytochrome P-450; gallic acid; gene expression; gene expression regulation; human cell lines; in vitro studies; in vivo studies; ligands; neoplasm cells; neoplasm progression; promoter regions; prostaglandin synthase; signal transduction; tumor suppressor protein p53; women
Abstract:
... Despite the significant advances in diagnosis and treatment, breast cancer remains the most common malignancy and the second cause of death in women. Increasingly, preclinical evidence has suggested aryl hydrocarbon receptor (Ahr), a ligand activated transcription factor, a promising therapeutic target in breast cancer.This study aims at screening a number of phenolic compounds to identify an Ahr ...
DOI:
10.1016/j.phymed.2021.153817

13. Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation

Author:
Ya-Hui Yu; Li Wang; Qiang Zhang; Xiao-Nan Zhang; Xin-Huai Zhao
Source:
Current research in food science 2022 v.5 pp. 1071-1083
ISSN:
2665-9271
Subject:
Dimocarpus longan; antineoplastic activity; apoptosis; calcium; cell growth; colorectal neoplasms; food science; humans; longans; membrane potential; mitochondrial membrane; polysaccharides; reactive oxygen species; research; sulfates; uronic acids
Abstract:
... The soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides (LP) with Se content less than 0.01 g/kg were extracted and selenylated chemically with the HNO₃–Na₂SeO₃ system, to prepare two selenylated products namely SeLP1 and SeLP2 with enhanced Se contents of 1.46 and 4.79 g/kg, respectively. LP, SeLP1, and SeLP2 were then measured and compared for their saccharide features an ...
DOI:
10.1016/j.crfs.2022.06.008

14. Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation

Author:
Haroon Khan; Fabiana Labanca; Hammad Ullah; Yaseen Hussain; Nikolay T. Tzvetkov; Esra Küpeli Akkol; Luigi Milella
Source:
Phytochemistry reviews 2022 v.21 no.2 pp. 385-400
ISSN:
1568-7767
Subject:
DNA; antineoplastic activity; apoptosis; breasts; cancer therapy; cell cycle checkpoints; cell proliferation; dietary supplements; drug therapy; excision; gene expression; germ cells; immunotherapy; mortality; neoplasm progression; phytochemicals; polyphenols; radiotherapy; risk
Abstract:
... Over the years, the attention towards the role of phytochemicals in dietary natural products in reducing the risk of developing cancer is rising. Cancer is the second primary cause of mortality worldwide. The current therapeutic options for cancer treatment are surgical excision, immunotherapy, chemotherapy, and radiotherapy. Unfortunately, in case of metastases or chemoresistance, the treatment o ...
DOI:
10.1007/s11101-021-09771-3

15. Ag nanoparticles enhance immune checkpoint blockade efficacy by promoting of immune surveillance in melanoma

Author:
Xinwei Kuang; Zhenxing Wang; Zhongwei Luo; Zehui He; Long Liang; Qian Gao; Youyou Li; Kun Xia; Zuozhong Xie; Ruimin Chang; Yiyi Wang; Yiwei Liu; Shuang Zhao; Juan Su; Yang Wang; Weiyi Situ; Mingliang Chen; Yuetao Zhao; Xiang Chen; Hui Xie; Hong Liu
Source:
Journal of colloid and interface science 2022 v.616 pp. 189-200
ISSN:
0021-9797
Subject:
antineoplastic activity; apoptosis; cell proliferation; cytotoxicity; immunotherapy; immunotoxicity; ligands; melanoma; monitoring; nanosilver; neoplasm cells; sucrose
Abstract:
... Immune checkpoint blockade (ICB) therapy, represented by programmed cell death protein 1 (PD-1) and its ligand (PD-L1) monoclonal antibodies (mAbs), has shown an obvious benefit for melanoma immunotherapy, but the overall response rate is still low. To find an effective combination therapy strategy, we successfully produced small size silver nanoparticles coated with sucrose (S-AgNPs) as potent ad ...
DOI:
10.1016/j.jcis.2022.02.050

16. Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells

Author:
Ying Liu; Xiaobei Liu; Hui Wang; Pingping Ding; Changlin Wang
Source:
Phytomedicine 2022 v.101 pp. 154102
ISSN:
0944-7113
Subject:
Agrimonia pilosa; antineoplastic activity; apoptosis; computer software; databases; energy; ferroptosis; flow cytometry; immunoblotting; iron; models; mortality; neoplasm cells; neoplasm progression; ovarian neoplasms; reactive oxygen species; toxicity testing; toxicogenomics; xenotransplantation
Abstract:
... Ovarian cancer is a gynaecological tumour has high incidence and mortality rates. Agrimonolide, isolated from Agrimonia pilosa Ledeb, has multiple biomedical activities, including anticancer activity. Here, we aimed to reveal the function of agrimonolide on ovarian cancer progression. MTT assay, colony-formation assay, flow cytometry, transwell assay, scratch test, western immunoblotting, reactive ...
DOI:
10.1016/j.phymed.2022.154102

17. Alhagi honey polysaccharides encapsulated into PLGA nanoparticle-based pickering emulsion as a novel adjuvant to induce strong and long-lasting immune responses

Author:
Adelijiang Wusiman; Jin He; Gaofeng Cai; Tianyu Zhu; Ruonan Bo; Zhenguang Liu; Yuanlaing Hu; Deyun Wang
Source:
International journal of biological macromolecules 2022 v.202 pp. 130-140
ISSN:
0141-8130
Subject:
Alhagi maurorum; adsorption; antineoplastic activity; cytokines; emulsions; honey; humoral immunity; lymph; perennials; polysaccharides; vaccine adjuvants
Abstract:
... Alhagi honey polysaccharides, extracted from a perennial plant Alhagi pseudalhagi syn, possessed many biological activities such as immune enhancement, anti-tumor effect, and antioxygenation. In this study, we used Alhagi honey polysaccharide encapsulated (poly lactic-co-glycolic acid) (PLGA) nanoparticles to prepare an assembled particles-oil pickering emulsion: PPAS and PEI-PPAS. We investigated ...
DOI:
10.1016/j.ijbiomac.2022.01.020

18. Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis

Author:
Linlin Wang; Li Cheng; Li Ma; Ammad Ahmad Farooqi; Gan Qiao; Yuxi Zhang; Hanlin Ye; Minghua Liu; Jianlin Huang; Xiaohui Yang; Xiukun Lin; Shousong Cao
Source:
Phytotherapy research 2022 v.36 no.1 pp. 525-542
ISSN:
0951-418X
Subject:
acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; growth retardation; hepatoma; humans; liver; membrane potential; mitochondrial membrane; phytotherapy; research; xenotransplantation
Abstract:
... Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results showed that alnu ...
DOI:
10.1002/ptr.7337

19. Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways

Author:
Hyeon Jeong Kim; Ji Won Choi; Jin Ree; Jung Sik Lim; Jisun Lee; Jun Il Kim; Samir Bahadur Thapa; Jae Kyung Sohng; Yong Il Park
Source:
Life sciences 2022 v.300 pp. 120495
ISSN:
0024-3205
Subject:
Aloe; DNA fragmentation; Western blotting; antineoplastic activity; apoptosis; caspase-9; cell growth; cell movement; cytotoxicity; emodin; glycosylation; histopathology; humans; intraperitoneal injection; lung neoplasms; membrane potential; mitochondrial membrane; mortality; neoplasm cells; water solubility; xenotransplantation
Abstract:
... Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer with a high mortality rate. Glycosylation of phenolic compounds may increase water-solubility and pharmacological activities and reduce the toxicity of aglycones. This study aimed to evaluate and compare the anticancer effect of aloe emodin 3-O-glucoside (AE3G) and its aglycone, aloe emodin (AE), against NSCLC. A human ade ...
DOI:
10.1016/j.lfs.2022.120495

20. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects

Author:
Sameena Gul; Muhammad Faisal Maqbool; Dongying Zheng; Yongming Li; Muhammad Khan; Tonghui Ma
Source:
Applied biochemistry and biotechnology 2022 v.194 no.9 pp. 4220-4243
ISSN:
0273-2289
Subject:
antineoplastic activity; biotechnology; cancer therapy; dietary supplements; drug therapy; flavonoids; humans; immunosuppression
Abstract:
... Cancer is a global burden and mechanistically complex disease with a plethora of genetic, physiological, metabolic, and environmental alterations. The development of dietary nutraceuticals into cancer chemotherapeutics has emerged as a new paradigm in cancer treatment. Alpinetin (ALPI) is a novel flavonoid component of multiple edible and medicinal plants and possesses a wide range of biological a ...
DOI:
10.1007/s12010-022-03960-2