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1. Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities

Author:
Manar M. Mahmoud; Ahmed S. Abdel-Razek; Hesham S.M. Soliman; Larissa V. Ponomareva; Jon S. Thorson; Khaled A. Shaaban; Mohamed Shaaban
Source:
Biotechnology reports 2022 v.33 pp. e00628
ISSN:
2215-017X
Subject:
Alternaria; Cystoseira; antineoplastic activity; biotechnology; cytotoxicity; endophytes; fungi; neoplasm cells; phenotype; polyketides; tenuazonic acid; Egypt; Red Sea
Abstract:
... We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR m ...
DOI:
10.1016/j.btre.2021.e00628

2. (3,3’-Methylene)bis-2-hydroxy-1,4-naphthoquinones induce cytotoxicity against DU145 and PC3 cancer cells by inhibiting cell viability and promoting cell cycle arrest

Author:
Paula Priscilla de Freitas; Ruan Carlos Busquet Ribeiro; Isabella dos Santos Guimarães; Caroline S. Moreira; David R. Rocha; Fernando de Carvalho da Silva; Vitor Francisco Ferreira; Etel Rodrigues Pereira Gimba
Source:
Molecular biology reports 2021 v.48 no.4 pp. 3253-3263
ISSN:
0301-4851
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; cell viability; cytotoxicity; drug resistance; drug therapy; flow cytometry; metastasis; molecular biology; prostatic neoplasms
Abstract:
... We developed a novel method for the synthesis of bis-naphthoquinones (BNQ), which are hybrids of lawsone (2-hydroxy-1,4-naphthoquinone) and 3-hydroxy-juglone (3,5-dihydroxy-1,4-naphthoquinone). The anticancer activity of three synthesized compounds, named 4 (RC10), 5 (RCDFC), and 6 (RCDOH) was evaluated in vitro against two metastatic prostate cancer (PCa) cell lines, DU145 and PC3, using MTT assa ...
DOI:
10.1007/s11033-021-06406-w

3. (Poly-cyanoacrylate) nanomedicines for cancer and beyond: Lessons learned

Author:
P. Couvreur
Source:
Journal of controlled release 2021 v.334 pp. 318-326
ISSN:
0168-3659
Subject:
antineoplastic activity; biodegradability; chemical bonding; drugs; encapsulation; fluorescent dyes; hepatoma; humans; lipids; lysosomes; multiple drug resistance; nanocapsules; nanomedicine; polyacrylamide; squalene; therapeutics
Abstract:
... This « Magnum Opus » emphasizes that serendipity is a corner stone in research. The paths of discovery and innovation often result from the interdisciplinarity of scientific areas that are a priori disconnected from each other. In the 1970s, fundamental discoveries in cell biology led to unexpected advances in galenic pharmacy with the emergence of nanotechnologies for the intracellular delivery o ...
DOI:
10.1016/j.jconrel.2021.04.028

4. 1550 nm excitation-responsive upconversion nanoparticles to establish dual-photodynamic therapy against pancreatic tumors

Author:
Khang-Yen Pham; Liu-Chun Wang; Chia-Ching Hsieh; Ya-Ping Hsu; Li-Chan Chang; Wen-Pin Su; Yi-Hsin Chien; Chen-Sheng Yeh
Source:
Journal of materials chemistry B 2021 v.9 no.3 pp. 694-709
ISSN:
2050-7518
Subject:
antineoplastic activity; chemistry; chlorins; irradiation; marriage; nanocarriers; singlet oxygen
Abstract:
... The second near-infrared biological window b (NIR-IIb, 1500–1700 nm) is recently considered as the promising region for deeper tissue penetration. Herein, a nanocarrier for 1550 nm light-responsive dual-photodynamic therapy (PDT) is developed to efficiently boost singlet oxygen (¹O₂) generation. The dual-photosensitizers (PSs), rose bengal (RB) and chlorin e6 (Ce6), are carried by the silica-coate ...
DOI:
10.1039/d0tb02655g

5. 2α-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action

Author:
Mohamed-Elamir F. Hegazy; Mona Dawood; Nuha Mahmoud; Mohamed Elbadawi; Yoshikazu Sugimoto; Sabine M. Klauck; Nagla Mohamed; Thomas Efferth
Source:
Phytomedicine 2021 v.81 pp. 153409
ISSN:
0944-7113
Subject:
DNA damage; P-glycoproteins; Pulicaria undulata; antineoplastic activity; apoptosis; cell cycle checkpoints; cytotoxicity; epidermal growth factor receptors; gene expression regulation; gene overexpression; human cell lines; leukemia; mechanism of action; medicinal plants; messenger RNA; microarray technology; multiple drug resistance; neoplasm cells; phosphatidylinositol 3-kinase; sesquiterpenoid lactones; transcriptome; transcriptomics
Abstract:
... Sesquiterpene lactones having α-methylene-γ-lactone moiety are promising natural metabolites showing various biological activity. One of the major metabolites isolated from Pulicaria undulata, 2α-hydroxyalantolactone (PU-1), has not been investigated in detail yet. Multidrug resistance (MDR) represents a major obstacle for cancer chemotherapy and the capability of novel natural products to overcom ...
DOI:
10.1016/j.phymed.2020.153409

6. 5-Desmethylsinensetin isolated from Artemisia princeps suppresses the stemness of breast cancer cells via Stat3/IL-6 and Stat3/YAP1 signaling

Author:
Ren Liu; Hack Sun Choi; Yu-Chan Ko; Bong-Sik Yun; Dong-Sun Lee
Source:
Life sciences 2021 v.280 pp. 119729
ISSN:
0024-3205
Subject:
Artemisia princeps; antineoplastic activity; apoptosis; breast neoplasms; breasts; flow cytometry; gels; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; silica gel; stem cells
Abstract:
... To study 5-desmethylsinensetin exhibiting potential anticancer activity against breast cancer stem cells and the related molecular mechanism.In this study, isolation of a cancer stem cell (CSC) inhibitor of Artemisia princeps was performed using a silica gel column, a Sephadex gel column, and high-performance liquid chromatography. A single compound was purified via activity-based isolation using ...
DOI:
10.1016/j.lfs.2021.119729

7. 9-amino acid cyclic peptide-decorated sorafenib polymeric nanoparticles for the efficient in vitro nursing care analysis of hepatocellular carcinoma

Author:
Yue Hu; Dan Yu; Xiaoxia Zhang
Source:
Process biochemistry 2021 v.100 pp. 140-148
ISSN:
1359-5113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; drug therapy; flow cytometry; hepatoma; mortality; neoplasm cells; peptides; polymers; solubility; toxicity
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Sorafenib acts as a potential anticancer agent, but it shows less aqueous solubility, so its clinical application is limited. In this present study, we developed Sora-surface decorated iRGD (small cyclic peptide motif (CRGDK/RGPD/EC)) nanoparticles (labelled Sora-NPs and iRGD@Sora-NPs, respective ...
DOI:
10.1016/j.procbio.2020.09.021

8. A PEGylated alternating copolymeric prodrug of sulfur dioxide with glutathione responsiveness for Irinotecan delivery

Author:
Yu Zhang; Hongyu Zhang; Pan He; Xuan Yi; Xinming Liu; Chunsheng Xiao
Source:
Journal of materials chemistry B 2021 v.9 no.1 pp. 187-194
ISSN:
2050-7518
Subject:
antineoplastic activity; copolymerization; drug therapy; drugs; glutathione; neoplasm cells; neoplasms; polymers; reactive oxygen species; sulfur dioxide
Abstract:
... In this study, an enhanced anticancer strategy combining the chemotherapy from antineoplastics with the oxidative damage from a sulfur dioxide (SO₂) prodrug is presented. Based on the characteristics of a high glutathione (GSH) level in the tumor microenvironment, a novel GSH-responsive SO₂ polymeric prodrug mPEG-b-P(PA-alt-GDNs) was designed and synthesized via a ring-opening alternating copolyme ...
DOI:
10.1039/d0tb02097d

9. A bibliometric review of oncolytic virus research as a novel approach for cancer therapy

Author:
Amir Sasan Mozaffari Nejad; Tehjeeb Noor; Ziaul Haque Munim; Mohammad Yousef Alikhani; Amir Ghaemi
Source:
Virology journal 2021 v.18 no.1 pp. 98
ISSN:
1743-422X
Subject:
Adenoviridae; Avian orthoavulavirus 1; Reoviridae; antineoplastic activity; biomedical research; cancer therapy; databases; herpes simplex; systematic review; virology; viruses; Canada; Finland
Abstract:
... BACKGROUND: In recent years, oncolytic viruses (OVs) have drawn attention as a novel therapy to various types of cancers, both in clinical and preclinical cancer studies all around the world. Consequently, researchers have been actively working on enhancing cancer therapy since the early twentieth century. This study presents a systematic review of the literature on OVs, discusses underlying resea ...
DOI:
10.1186/s12985-021-01571-7

10. A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis

Author:
Hiroyuki Tani; Ryo Miyamoto; Syunya Noguchi; Sena Kurita; Tomokazu Nagashima; Masaki Michishita; Naoko Yayoshi; Kyoichi Tamura; Makoto Bonkobara
Source:
BMC veterinary research 2021 v.17 no.1 pp. 147
ISSN:
1746-6148
Subject:
antineoplastic activity; case studies; disease progression; dogs; drugs; edema; halitosis; hemorrhage; lymph nodes; melanoma; metastasis; phosphorylation; proto-oncogenes; receptor protein-tyrosine kinase; sequence deletion; therapeutics; tyrosine; veterinary medicine
Abstract:
... BACKGROUND: Canine malignant melanoma is highly aggressive and generally chemoresistant. Toceranib is a kinase inhibitor drug that inhibits several tyrosine kinases including the proto-oncogene receptor tyrosine kinase KIT. Although canine malignant melanoma cells often express KIT, a therapeutic effect for toceranib has yet to be reported for this tumor, with only a small number of patients studi ...
DOI:
10.1186/s12917-021-02864-3

11. A cannabidiol-loaded Mg-gallate metal–organic framework-based potential therapeutic for glioblastomas

Author:
Anu Sharma; Abhishek Kumar; Changning Li; Puja Panwar Hazari; Supriya D. Mahajan; Ravikumar Aalinkeel; Rakesh Kumar Sharma; Mark T. Swihart
Source:
Journal of materials chemistry B 2021 v.9 no.10 pp. 2505-2514
ISSN:
2050-7518
Subject:
antineoplastic activity; apoptosis; brain neoplasms; cannabidiol; cell growth; coordination polymers; gallic acid; glioblastoma; humans; magnesium; mitochondria; neoplasm cells; porous media; rats; reactive oxygen species; therapeutics; toxicity
Abstract:
... Cannabidiol (CBD) has been shown to slow cancer cell growth and is toxic to human glioblastoma cell lines. Thus, CBD could be an effective therapeutic for glioblastoma. In the present study, we explored the anticancer effect of cannabidiol loaded magnesium-gallate (CBD/Mg-GA) metal–organic framework (MOF) using the rat glioma brain cancer (C6) cell line. Bioactive and microporous magnesium gallate ...
DOI:
10.1039/d0tb02780d

12. A carrier-free anti-inflammatory platinum (II) self-delivered nanoprodrug for enhanced breast cancer therapy

Author:
Lei Xing; Chen-Xi Yang; Di Zhao; Li-Jun Shen; Tian-Jiao Zhou; Yu-Yang Bi; Zhang-Jian Huang; Qiong Wei; Ling Li; Fei Li; Hu-Lin Jiang
Source:
Journal of controlled release 2021 v.331 pp. 460-471
ISSN:
0168-3659
Subject:
antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; cisplatin; drug therapy; metastasis; platinum; prostaglandin synthase; prostaglandins; secretion
Abstract:
... Cisplatin is one of the most used first-line anticancer drugs for various solid tumor therapies. However, cisplatin-based chemotherapy can induce tumor cells to secrete excessive prostaglandin E2 (PGE2) catalyzed by cyclooxygenase-2 (COX-2), which, in turn, counteracts its chemotherapeutic effect and further accelerates tumor metastasis. Here, we report a carrier-free self-delivered nanoprodrug ba ...
DOI:
10.1016/j.jconrel.2021.01.037

13. A clinically acceptable strategy for sensitizing anti-PD-1 treatment by hypoxia relief

Author:
Mengshi Jiang; Bing Qin; Lihua Luo; Xiang Li; Yingying Shi; Junlei Zhang; Zhenyu Luo; Chunqi Zhu; Guannan Guan; Yongzhong Du; Jian You
Source:
Journal of controlled release 2021 v.335 pp. 408-419
ISSN:
0168-3659
Subject:
animals; antibodies; antineoplastic activity; biosafety; breast neoplasms; colorectal neoplasms; hemoglobin; hyperoxia; hypoxia; immunotherapy; intravenous injection; macrophages; oxygen; perfluorocarbons; pharmacodynamics; programmed cell death
Abstract:
... The hypoxic tumor microenvironment (TME) hinders the effectiveness of immunotherapy. Alleviating tumor hypoxia to improve the efficacy of immune checkpoint inhibitors (ICIs) represented by programmed cell death protein 1 (PD-1) antibody has become a meaningful strategy. In this study, we adopted three methods to alleviate hypoxia, including direct oxygen delivery using two different carriers and a ...
DOI:
10.1016/j.jconrel.2021.06.001

14. A combination index and glycoproteomics-based approach revealed synergistic anticancer effects of curcuminoids of turmeric against prostate cancer PC3 cells

Author:
Meng-Meng Wei; Shu-Juan Zhao; Xue-Man Dong; Yong-Jie Wang; Can Fang; Pu Wu; Gao-Qian Song; Jun-Na Gao; Zhi-Hui Huang; Tian Xie; Jian-Liang Zhou
Source:
Journal of ethnopharmacology 2021 v.267 pp. 113467
ISSN:
0378-8741
Subject:
Curcuma longa; Western blotting; additive effect; antineoplastic activity; apoptosis; biosynthesis; cancer therapy; cell cycle; cell lines; cell viability; curcumin; gluconeogenesis; glycolysis; glycoproteomics; mass spectrometry; neoplasm cells; prostatic neoplasms; rhizomes; ribosomes; synergism; turmeric
Abstract:
... Herbal medicines (HMs) often exert integration effects, including synergistic, additive and antagonistic effects, in such ways that they act on multiple targets and multiple pathways on account of their multiple components. Turmeric, made from the rhizome of Curcuma longa L., is a well-known HM prescribed in the polyherbal formulas for cancer treatment in traditional Chinese medicines (TCMs). Howe ...
DOI:
10.1016/j.jep.2020.113467

15. A dual-functional biomimetic-mineralized nanoplatform for glucose detection and therapy with cancer cells in vitro

Author:
Chunlei Yang; Mengxu Gao; Hengzhi Zhao; Yazhou Liu; Na Gao; Jing Jing; Xiaoling Zhang
Source:
Journal of materials chemistry B 2021 v.9 no.18 pp. 3885-3891
ISSN:
2050-7518
Subject:
absorption; antineoplastic activity; blood serum; cancer therapy; catalytic activity; detection limit; diabetes mellitus; doxorubicin; drug therapy; energy transfer; fluorescence; glucose; glucose oxidase; hypoglycemia; neoplasms; pH; people; porous media; risk; starvation
Abstract:
... Glucose detection is a crucial topic in the diagnosis of numerous diseases, such as hypoglycemia or diabetes mellitus. Research indicates that people with diabetes mellitus are at a higher risk of developing various types of cancer. A nanoplatform that combines both diabetes diagnosis and cancer therapy might be regarded as a more effective way to solve the above-mentioned problem. However, none o ...
DOI:
10.1039/d1tb00324k

16. A dual-prodrug nanoparticle based on chitosan oligosaccharide for enhanced tumor-targeted drug delivery

Author:
Xia Chen; David H. Bremner; Yuhan Ye; Jiadong Lou; Shiwei Niu; Li-Min Zhu
Source:
Colloids and surfaces 2021 v.619 pp. 126512
ISSN:
0927-7757
Subject:
antineoplastic activity; apoptosis; chitosan; doxorubicin; drug therapy; neoplasms; oleanolic acid; oligosaccharides; pH; risk
Abstract:
... The premature leakage of chemotherapeutics during delivery impedes drugs from entering tumor cells, which produces considerable side effects in normal organs. Herein, we describe a hydrophobic-hydrophilic balanced self-assembled prodrug nanoparticle (HA-DOX@HA-CSO-g-OA), formed via a facile synthesis based on chitosan oligosaccharide to reduce the non-targeting risk of premature leakage of chemoth ...
DOI:
10.1016/j.colsurfa.2021.126512

17. A feasible strategy of fabricating hybrid drugs encapsulated polymeric nanoparticles for the treatment of gastric cancer therapy

Author:
Heng Li; Fanglan Li; Ying Sun; Yuqiang Li
Source:
Process biochemistry 2021 v.109 pp. 19-26
ISSN:
1359-5113
Subject:
acridine orange; antineoplastic activity; apoptosis; biotin; cancer therapy; capsaicin; drug therapy; encapsulation; ethidium; flow cytometry; humans; neoplasm cells; polyethylene glycol; stomach neoplasms; transmission electron microscopy
Abstract:
... Chemotherapy of hybrid-drugs has become one of the widely used therapies for the prevention of cancers with promising clinical results. This study aimed to create compostable polymeric nanoparticles (PPNPs) for the codelivery of capsaicin (CAPS) and biotin (BT) and to examine the anticancer activity of the drug delivery mechanism (CAPS/BT@PPNPs) against in vitro and in vivo gastric cancer cells. B ...
DOI:
10.1016/j.procbio.2021.06.001

18. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

Author:
Dou-Dou XU; Xiao-Ying HOU; Ou WANG; Di WANG; Dan-Ting LI; Si-Yuan QIN; Bo LV; Xiao-Min DAI; Zun-Jian ZHANG; Jian-Bo WAN; Feng-Guo XU
Source:
Chinese journal of natural medicines 2021 v.19 no.5 pp. 364-375
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; baicalin; cancer therapy; cell movement; cell proliferation; diarrhea; gastrointestinal system; glycyrrhizin; macrophages; models; toxicity; toxicity testing; xenotransplantation
Abstract:
... Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to scre ...
DOI:
10.1016/S1875-5364(21)60034-1

19. A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions

Author:
Sameh A. Rizk; Maher A. El-Hashash; Amr A. Youssef; Abdelfattah T. Elgendy
Source:
Heliyon 2021 v.7 no.3 pp. e06220
ISSN:
2405-8440
Subject:
activation energy; anise; antineoplastic activity; antineoplastic agents; chemical equilibrium; entropy; isomers; models; nuclear magnetic resonance spectroscopy; oils; spectral analysis; temperature; thermal stability
Abstract:
... Conventional synthesis of the phthalazine has already allowed affording the phthalazin-1-one phthalazin-1-ol dynamic equilibrium that decreases the anticancer activity due to diminishing the concentration of the phthalazin-1-ol product. Nowadays, pure phthalazin-1-ol (5) can be gaining by using green microwave tools that increase the power of the phthalazine nucleus as an anticancer drug. A micros ...
DOI:
10.1016/j.heliyon.2021.e06220

20. A hybrid HPV capsid protein L1 with giant Mo-containing polyoxometalate improves the stability of virus-like particles and the anti-tumor effect of [Mo₁₅₄]

Author:
Ya-Rong Xue; Yu Wang; Gang Chen; Bo Sun; Bao Li; Lixin Wu; Yuqing Wu
Source:
Biomaterials science 2021 v.9 no.10 pp. 3875-3883
ISSN:
2047-4849
Subject:
antineoplastic activity; antineoplastic agents; biocompatibility; biocompatible materials; centrifugation; coat proteins; hybrids; infrared radiation; irradiation; pH; polyacrylamide gel electrophoresis; storage time; temperature; transmission electron microscopy
Abstract:
... We report a bio-inorganic hybrid system, [Mo₁₅₄]@VLPs, constructed from the virus-like particles (VLPs) of the HPV capsid protein L1 and a giant disc-shaped, molybdenum-containing polyoxometalate of [Mo₁₅₄]. The hybrid was purified by CsCl gradient centrifugation and further validated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), dynamic light scattering (DLS) and transm ...
DOI:
10.1039/d1bm00138h