Subject term: antineoplastic activity

1. Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation

Author:: Jan Grzybek; Izabella Zgórniak-Nowosielska; Andrzej Kasprowicz; Barbara Zawilińska; Stanisław Kohlmunzer
Source:: Acta Societatis Botanicorum Poloniae 1994 v.63 no.3-4 pp. 293-298
ISSN:: 0001-6977
Subject:: Propionibacterium acnes; Tylopilus; antineoplastic activity; cytotoxicity; fruiting bodies; fungi; glucans; immune response; in vitro studies; mice; neoplasm cells
Abstract:: ... The study evaluated the antitumor activity of tylopilan, aβ- (1→3) (1→6) linked glucan isolated from fruiting bodies of Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae), and Propionibacterium acnes (P.a.) preparation. The antitumor effect of tylopilan and P.a. used alone or in combination was studied in NMRI mice inoculated i.p. with 106 180-TG Crocker tumor cells. All experiments were based ...
DOI:: 10.5586/asbp.1994.040
: https://doi.org/10.5586/asbp.1994.040

2. Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives

Author:: In Jong Kim; Yea Jin Park; Joo il Kim; Kyung Tae Lee; Sin Kyu Kim
Source:: Archives of pharmacal research 1997 v.20 no.5 pp. 476
ISSN:: 0253-6269
Subject:: antineoplastic activity; in vitro studies; neoplasm cells; synthesis
Abstract:: ... Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell. ...
DOI:: 10.1007/BF02973943
: https://doi.org/10.1007/BF02973943

3. 6-(1-Alkenoyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives: Synthesis and evaluation of antitumor activity

Author:: Young-Jae You; Byung-Zun Ahn
Source:: Archives of pharmacal research 1998 v.21 no.6 pp. 738
ISSN:: 0253-6269
Subject:: antineoplastic activity; cytotoxicity; mice; naphthoquinones
Abstract:: ... Thirty six 5,8-dimethoxy-1,4-naphthoquinone derivatives, which bear unsaturated alkyl side chain with ester bond, were synthesized and tested cytotoxic activity on L1210 cells and antitumor activity against ICR mice bearing S-180 cells. It could be recognized that the cytotoxicities of naphthoquinones with R₁ being methyl and propyl (IV1∼24) were not enhanced by replacing the alkanoyls with alkeno ...
DOI:: 10.1007/BF02976768
: https://doi.org/10.1007/BF02976768

4. Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains

Author:: Tadashi KIHO; Mitsuhiro MATSUSHITA; Shigeyuki USUI; Shigeo UKAI
Source:: Bioscience, biotechnology, and biochemistry 1998 v.62 no.3 pp. 570-572
ISSN:: 1347-6947
Subject:: antineoplastic activity; biotechnology; carbon; curdlan; glucans; glucose; macrophages; sarcoma
Abstract:: ... Newly synthesized (1→3)-β-D-glucans with reducing glucose side chains (6-O-glucopyranosylated curdlan and 3-O-glucopyranosylated curdlan, with glucose linked directly (except for anomeric carbon) had antitumor activity against mice sarcoma 180 in mice. The two glucans potentiated the reticuloendotheliai system and activated macrophages (increased their glucose consumption). The activity inducing t ...
DOI:: 10.1271/bbb.62.570
: https://doi.org/10.1271/bbb.62.570

5. Inhibition of Topoisomerases by Antitumor Prostaglandins.

Author:: Keitarou SUZUKI; Fumiko SHONO; Masaru UYEDA
Source:: Bioscience, biotechnology, and biochemistry 1998 v.62 no.10 pp. 2073-2075
ISSN:: 1347-6947
Subject:: antineoplastic activity; biotechnology; calves; dose response; humans; neoplasms; placenta; prostaglandins; thymus gland
Abstract:: ... Topoisomerase II from human placenta was strongly inhibited by prostaglandins such as Δ ¹²,¹⁴-PGJ₂, Δ ¹²-PGJ₂, PGA₂, and PGA₁, which have an antitumor activity. The topoisomerase II inhibitions by these prostaglandins were dose-dependent and IC₅₀ values of Δ ¹²,¹⁴-PGJ₂, Δ ¹²-PGJ₂, PGA₂, and PGA₁ were 22 μM, 74 μM, 75 μM, and 98 μM, respectively. Topoisomerase I from calf thymus gland was inhibited ...
DOI:: 10.1271/bbb.62.2073
: https://doi.org/10.1271/bbb.62.2073

6. Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice

Author:: Masashi MIZUNO; Mikio MORIMOTO; Ken-ichiro MINATO; Hironobu TSUCHIDA
Source:: Bioscience, biotechnology, and biochemistry 1998 v.62 no.3 pp. 434-437
ISSN:: 1347-6947
Subject:: Agaricus subrufescens; T-lymphocytes; antineoplastic activity; cytotoxicity; flow cytometry; humans; mice; nuclear magnetic resonance spectroscopy; oral administration; polysaccharides; sarcoma; water solubility
Abstract:: ... Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. ¹³C-NMR data indicates that the main compone ...
DOI:: 10.1271/bbb.62.434
: https://doi.org/10.1271/bbb.62.434

7. Antitumor Activity of Phenylahistin in Vitro and in Vivo

Author:: Kaneo KANOH; Shinkichi KOHNO; Jun KATADA; Yoshio HAYASHI; Michiko MURAMATSU; Isao UNO
Source:: Bioscience, biotechnology, and biochemistry 1999 v.63 no.6 pp. 1130-1133
ISSN:: 1347-6947
Subject:: Aspergillus; antineoplastic activity; biotechnology; cell cycle; enantiomers; leukemia; lung neoplasms; neoplasm cells
Abstract:: ... Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC₅₀ values ranging from 1.8×10⁻⁷ to 3.7×10⁻⁶, while (+)-phenylahistin e ...
DOI:: 10.1271/bbb.63.1130
: https://doi.org/10.1271/bbb.63.1130

8. Anticancer effects of selenium compounds on human colonic carcinoma cells

Author:: Lj. Glavaš-Obrovac; T. Klapec; I. Karner; M. L. Mandić
Source:: Acta alimentaria 2000 v.29 no.3 pp. 295-306
ISSN:: 0139-3006
Subject:: antineoplastic activity; apoptosis; cell viability; colorectal neoplasms; cytotoxicity; epidemiological studies; humans; lymph nodes; metastasis; neoplasm cells; protective effect; selenium; selenomethionine; sodium selenite
Abstract:: ... Studies performed so far on different human carcinoma cell lines, as well as numerous case-control and epidemiological studies have given proof to the protective effects of selenium against cancer. However, the anticancer properties of selenium are site-specific. The aim of this work was to evaluate the cytotoxic effect of selenium against CaCo2 human colon carcinoma cells, and SW620 lymph node me ...
DOI:: 10.1556/AAlim.29.2000.3.8
: https://doi.org/10.1556/AAlim.29.2000.3.8

9. Solution Properties of Antitumor Sulfated Derivative of α-(1→3)-D-Glucan from Ganoderma lucidum

Author:: Lina ZHANG; Mei ZHANG; Qi ZHOU; Jinghua CHEN; Fanbo ZENG
Source:: Bioscience, biotechnology, and biochemistry 2000 v.64 no.10 pp. 2172-2178
ISSN:: 1347-6947
Subject:: Ganoderma lucidum; antineoplastic activity; aqueous solutions; ascites; biotechnology; carcinoma; curdlan; equations; glucans; hydrogen; molecular weight; sulfur; viscometry; viscosity; water solubility
Abstract:: ... Four fractions of a water-insoluble α-(1→3)-D-glucan GL extracted from fruiting bodies of Ganoderma lucidum were dissolved in 0.25 M LiCl/DMSO, and then reacted with sulfur trioxide-pyridine complex at 80°C to synthesize a series of water-soluble sulfated derivatives S-GL. The degree of substitution of DS was measured by using IR infrared spectra, elemental analysis, and ¹³C NMR to be 1.2-1.6 in t ...
DOI:: 10.1271/bbb.64.2172
: https://doi.org/10.1271/bbb.64.2172

10. Antitumor Effect of Photodynamic Therapy with Zincphyrin, Zinc-coproporphyrin III, in Mice

Author:: Minoru TORIYA; Megumi YAMAMOTO; Kenji SAEKI; Yoshie FUJII; Kazuhiko MATSUMOTO
Source:: Bioscience, biotechnology, and biochemistry 2001 v.65 no.2 pp. 363-370
ISSN:: 1347-6947
Subject:: antineoplastic activity; biotechnology; blood serum; body weight; death; intraperitoneal injection; irradiation; light; neoplasms; photochemotherapy; photosensitizing agents; phototoxicity; zinc
Abstract:: ... We studied the antitumor effects of photodynamic therapy (PDT) with Zincphyrin, coproporphyrin III with zinc, derived from Streptmyces sp. AC8007, in vitro and in vivo. The photokilling effect of Zincphyrin in the presence of 0.78-100 μg/ml with visible light of 27.2 mW·min/cm² for 10min was lower than the hematoporphyrin (Hp) used as a control with L5178Y or sarcoma-180 cells. On the other hand, ...
DOI:: 10.1271/bbb.65.363
: https://doi.org/10.1271/bbb.65.363

11. Apoptosis-inducing Activity of a Driselase Digest Fraction of Green Tea Residue

Author:: Yuko KATSUNO; Yu KOYAMA; Kouichi SAEKI; Masaki SAZUKA; Katsumasa OOKAWA; Mamoru ISEMURA
Source:: Bioscience, biotechnology, and biochemistry 2001 v.65 no.1 pp. 198-201
ISSN:: 1347-6947
Subject:: B-cell lymphoma; antineoplastic activity; apoptosis; biotechnology; death; endo-1,4-beta-glucanase; ethanol; green tea; humans; polygalacturonase; proteinases
Abstract:: ... We enzymatically digested green tea residue with Driselase, a crude preparation containing cellulase, pectinase and proteases, in order to examine the potential usefulness of the residue. A fraction of the digest soluble in 70% ethanol was found to induce the death of U937 human histiocytic lymphoma cells by apoptosis. Other enzyme preparations gave similar products with cell death-inducing activi ...
DOI:: 10.1271/bbb.65.198
: https://doi.org/10.1271/bbb.65.198

12. In Vivo Antitumor Efficacy of CW252053, A Folate-based Thymidylate Synthase Inhibitor

Author:: Se-Woong Oh; Jong-Ryul Ha; Du-Jong Baek
Source:: Archives of pharmacal research 2001 v.24 no.4 pp. 323-326
ISSN:: 0253-6269
Subject:: antineoplastic activity; cytotoxicity; females; fluorouracil; intraperitoneal injection; lymphoma; mice; models; muscles; neoplasm cells; survival rate; thymidine kinase; thymidylate synthase
Abstract:: ... Previous studies have demonstrated that CW252053, a quinazoline antifolate, exhibits potent inhibitory activity against thymidylate synthase (TS) as well as cytotoxic activity against tumor cell linesin vitro. In this study, we evaluated thein vivo antitumor efficacy of CW252053 in the mouse tumor model. Female B6D2F₁ mice were injected with LY3.7.2C TK-/- (thymidine kinase deficient mouse lymphom ...
DOI:: 10.1007/BF02975100
: https://doi.org/10.1007/BF02975100

13. Relationship between Solubility of Grifolan, a Fungal 1,3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro

Author:: Ken-ichi ISHIBASHI; Noriko N. MIURA; Yoshiyuki ADACHI; Naohito OHNO; Toshiro YADOMAE
Source:: Bioscience, biotechnology, and biochemistry 2001 v.65 no.9 pp. 1993-2000
ISSN:: 1347-6947
Subject:: Grifola frondosa; antineoplastic activity; beta-glucans; cell lines; centrifugation; dimethyl sulfoxide; fungi; heat; heat treatment; immunomodulation; macrophages; molecular weight; sodium hydroxide; solubility; tumor necrosis factors; ultrafiltration
Abstract:: ... Grifolan, GRN, is a fungal antitumor β-glucan isolated from Grifola frondosa. Various studies suggested that the underlying mechanism of the antitumor activity of GRN is strongly related to immune modulation. In the previous publication (Adachi et al., 1994; Okazaki et al., 1995), we have shown that GRN activates macrophages to produce tumor necrosis factor (TNF) in vitro. In this study, the struc ...
DOI:: 10.1271/bbb.65.1993
: https://doi.org/10.1271/bbb.65.1993

14. Structure-activity relationship studies of isoquinolinone type anticancer agent

Author:: Seung Hoon Cheon; Joon Suck Park; Joon Yeol Lee; You Na Lee; Hyo Yi; Byung-Ho Chung; Bo-Gil Choi; Won-Jea Cho; Sang-Un Choi; Chong-Ock Lee
Source:: Archives of pharmacal research 2001 v.24 no.4 pp. 276-280
ISSN:: 0253-6269
Subject:: antineoplastic activity; antineoplastic agents; humans; neoplasms; structure-activity relationships
Abstract:: ... Substituted isoquinolin-1-ones (1) were synthesized to test theirin vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines. ...
DOI:: 10.1007/BF02975091
: https://doi.org/10.1007/BF02975091

15. Antiangiogenic activity ofBupleurum longiradiatum on human umbilical venous endothelial cells

Author:: Young-Jae You; Im-Seon Lee; Yong Kim; Ki-Hwan Bae; Byung-Zun Ahn
Source:: Archives of pharmacal research 2002 v.25 no.5 pp. 640-642
ISSN:: 0253-6269
Subject:: active ingredients; antineoplastic activity; cytotoxicity; endothelial cells; ethyl acetate; humans; lung neoplasms; mice; neoplasm cells
Abstract:: ... The ethyl acetate fraction ofBupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compoundsP1 andP2 completely inhibited the tube-like formation of HUVE cells at 30 μg/ml, below the cytotox ...
DOI:: 10.1007/BF02976936
: https://doi.org/10.1007/BF02976936

16. Augmentation of macrophage antitumor activities and nitric oxide production by oregonin

Author:: Seong-Soo Joo; Han-Jun Kim; Hee-Seung Kwon; Do-Ik Lee
Source:: Archives of pharmacal research 2002 v.25 no.4 pp. 457-462
ISSN:: 0253-6269
Subject:: Alnus hirsuta; antineoplastic activity; cytotoxicity; dose response; immunomodulators; macrophages; neoplasm cells; nitric oxide
Abstract:: ... Oregonin, a diarylheptanoid derivative fromAlnus hirsuta Turcz, Betulaceae, was evaluated for its antitumor activity. Oregonin, known to have an antitumor function, and is a novel immuno-modulator, which may augment macrophage activity. MTT assays and NO production tests were performed in order to investigate the cytotoxicity of oregonin in tumor cells and to examine its influence on macrophage in ...
DOI:: 10.1007/BF02976602
: https://doi.org/10.1007/BF02976602

17. Chemical modification of alisol B 23-acetate and their cytotoxic activity

Author:: SangMyung Lee; ByungSun Min; KiHwan Bae
Source:: Archives of pharmacal research 2002 v.25 no.5 pp. 608-612
ISSN:: 0253-6269
Subject:: antineoplastic activity; cytotoxicity; humans; mice; neoplasm cells
Abstract:: ... The twelve-protostane analogues were synthesized from alisol B 23-acetate and assessed for theirin vitro antitumor activity against six different human and murine tumor cell lines. Of the compounds synthesized, 23S-acetoxy-24R(25)-epoxy-11β,23S-dihydroxyprotost-13(17)-en-3-hy-droxy-imine (12) exhibited significant cytotoxic activities against A549, SK-OV3, B16-F10, and HT1080 tumor cells with ED⁵⁰ ...
DOI:: 10.1007/BF02976929
: https://doi.org/10.1007/BF02976929

18. Design and synthesis of isoindoloquinoline derivatives as potential antitumor agents

Author:: Heesoon Lee; llyeong Jeong; Sung-ll Yang
Source:: Archives of pharmacal research 2002 v.25 no.4 pp. 416
ISSN:: 0253-6269
Subject:: antineoplastic activity; antineoplastic agents; cytotoxicity; humans; neoplasms
Abstract:: ... A series of isoindoloquinoline derivatives was synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HCT15, SK-OV-3, MDA-MB-468 and T-47D). ...
DOI:: 10.1007/BF02976593
: https://doi.org/10.1007/BF02976593

19. Enhancement of nk cytotoxicity, antimetastasis and elongation effect of survival time in b16-f10 melanoma cells by oregonin

Author:: Seong-Soo Joo; Min-Soo Kim; Won-Sik Oh; Do-Ik Lee
Source:: Archives of pharmacal research 2002 v.25 no.4 pp. 493-499
ISSN:: 0253-6269
Subject:: Betulaceae; antineoplastic activity; cytotoxicity; immunomodulators; melanoma; metastasis; mice; natural killer cells; neoplasm cells
Abstract:: ... We investigated the antitumor activity of oregonin, a diarylheptanoid derivative purified fromAlnus hirsuta Turcz, Betulaceae. Oregonin is a potential novel immunomodulator, which augments the activation of natural killer (NK) cells, and thereby leads to a powerful antitumor activity. To evaluate the cytotoxicity of oregonin against tumor cells, we examined the effectiveness of NK cells and determ ...
DOI:: 10.1007/BF02976608
: https://doi.org/10.1007/BF02976608

20. Immunomodulatory activity of protein-bound polysaccharide extracted from chelidonium majus

Author:: Jie-Young Song; Hyun-Ok Yang; Suhk-Neung Pyo; In-Sung Jung; Seh-Yoon Yi; Yeon-Sook Yun
Source:: Archives of pharmacal research 2002 v.25 no.2 pp. 158
ISSN:: 0253-6269
Subject:: Chelidonium majus; antineoplastic activity; bone marrow cells; chromatography; cytotoxicity; immunomodulation; immunomodulators; macrophages; neoplasm cells; nitric oxide; polysaccharides; splenocytes
Abstract:: ... In the course of searching immunomodulators from natural sources, the protein-bound polysaccharide, CM-Ala, has been isolated from the water extract ofChelidonium majus L. (Papaveraceae). The immunostimulatory characteristics have been investigated in several experiments such as generation of activated killer (AK) cells, proliferation of splenocytes, activation of macrophages and granulocyte macro ...
DOI:: 10.1007/BF02976557
: https://doi.org/10.1007/BF02976557

21. In Vitro pharmacodynamics of CKD-602 in HT-29 cells

Author:: In-Sook Park; Mee Ryung Ahn; Soo Kyung Suh; Hong-Serck Choi; Soo Jung Sohn; Ji Sun Yang; Tae Moo Yoo; Hyo-Jeong Kuh
Source:: Archives of pharmacal research 2002 v.25 no.5 pp. 718-723
ISSN:: 0253-6269
Subject:: adenocarcinoma; animal models; antineoplastic activity; cytotoxicity; drugs; exposure duration; high performance liquid chromatography; humans; inhibitory concentration 50; neoplasm cells; Korean Peninsula
Abstract:: ... CKD-602 (7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin) is a recently-developed synthetic camptothecin analogue and currently under clinical development by Chong Kun Dang Pharm (Seoul, Korea). CKD-602 showed potent topoisomerase inhibitory activityin vitro and broad antitumor activity against various human tumor cells in vitro and in vivo in animal models. This study describes the pharmacodynam ...
DOI:: 10.1007/BF02976950
: https://doi.org/10.1007/BF02976950

22. Inhibitory Properties of Antitumor Prostaglandins against Topoisomerases

Author:: Keitarou SUZUKI; Masaru UYEDA
Source:: Bioscience, biotechnology, and biochemistry 2002 v.66 no.8 pp. 1706-1712
ISSN:: 1347-6947
Subject:: DNA; antineoplastic activity; biotechnology; calves; humans; placenta; prostaglandins; thymus gland; wheat germ
Abstract:: ... Prostaglandins (PGs) having antitumor activity such as Δ¹²,¹⁴-PGJ₂, Δ¹²-PGJ₂, PGA₂ and PGA₁ strongly inhibited topoisomerase II (topo II) from human placenta, the potential order of inhibitory activity of the PGs resembling that of the antitumor activity. PGs having no antitumor activity did not inhibit topo II. Δ¹²,¹⁴-PGJ₂ to be a potent inhibitor showed inhibitions to some extent against topo I ...
DOI:: 10.1271/bbb.66.1706
: https://doi.org/10.1271/bbb.66.1706

23. Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice

Author:: Yung Choon Yoo; Katsusuke Hata; Kyung Bok Lee; Ichiro Azuma
Source:: Archives of pharmacal research 2002 v.25 no.4 pp. 522-527
ISSN:: 0253-6269
Subject:: angiogenesis; antineoplastic activity; blood vessels; carcinoma; intravenous injection; melanoma; metastasis; mice; mineral oil; models; neoplasm cells
Abstract:: ... The antimetastatic effect of BCG-CWS, which was emulsified in an oil-in-water form with either Drakeol 6VR mineral oil (BCG-CWS/DK) or squalane (BCG-CWS/SQA), on lung metastasis produced by highly metastatic murine tumor cells, Colon26-M3.1 carcinoma cells and B16-BL6 melanoma cells, was investigated in syngeneic mice. An intravenous (i.v.) administration of BCG-CWS (100 mg/mouse) 1 day after tumo ...
DOI:: 10.1007/BF02976612
: https://doi.org/10.1007/BF02976612

24. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

Author:: Wasser, S.P.
Source:: Applied microbiology and biotechnology 2002 v.60 no.3 pp. 258-274
ISSN:: 0175-7598
Subject:: Basidiomycota; T-lymphocytes; antineoplastic activity; beta-glucans; carcinogenesis; chemical composition; culture media; drug therapy; drugs; fruiting bodies; immune response; medicinal fungi; medicine; metastasis; molecular weight; mushrooms; mycelium; neoplasm cells; neoplasms; schizophyllan; water solubility
Abstract:: ... The number of mushrooms on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of polysaccharides with antitumor and immuno-stimulating properties. Many, if not al ...
DOI:: 10.1007/s00253-002-1076-7
PubMed:: 12436306
: https://doi.org/10.1007/s00253-002-1076-7

25. Sulfated glycofuranans as inhibitors of melanoma lung metastasis

Author:: Hiroshi Kamitakahara; Fusako Nishigaki; Yuji Mikawa; Michiko Hori; Shigetomo Tsujihata; Takashi Fujii; Fumiaki Nakatsubo
Source:: Journal of wood science 2002 v.48 no.3 pp. 204-209
ISSN:: 1435-0211
Subject:: anticoagulant activity; antineoplastic activity; antineoplastic agents; binding capacity; curdlan; heparin; melanoma; metastasis; structure-activity relationships; sulfates; xylan
Abstract:: ... Chemically synthesized (1 → 5)-β-D-glucofuranan, (1 → 5)-β-D-galactofuranan, (1 → 5)-β-D-xylofuranan, (1 → 5)-α-L-arabinofuranan, natural xylan, and curdlan were sulfated to investigate their inhibitory activities on B16-BL6 lung metastasis and anticoagulant activities. (1 → 5)-β-D-Glucofuranan sulfate, (1 → 5)-β-D-galactofuranan sulfate, xylan sulfate, and curdlan sulfate had binding abilities wi ...
DOI:: 10.1007/BF00771368
: https://doi.org/10.1007/BF00771368

26. Synthesis of polyamides containingN-methylpyrrole andN-meth-ylimidazole and their anticancer activity

Author:: Gu Yuan; Junhua Xiao; Weiqiang Huang; Feili Tang; Yawei Zhou
Source:: Archives of pharmacal research 2002 v.25 no.5 pp. 585-589
ISSN:: 0253-6269
Subject:: antineoplastic activity; carcinoma; inhibitory concentration 50; lung neoplasms; polyamides
Abstract:: ... Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/ HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines-hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of IC₅₀ were at range of 10⁻⁷~10⁻⁸ M. ...
DOI:: 10.1007/BF02976926
: https://doi.org/10.1007/BF02976926

27. Synthesis, cytotoxicity and antitumor activity of 2,3-Diarylcy-clopent-2-ene-1-ones

Author:: Nguyen-Hai Nam; Yong Kim; Young-Jae You; Dong-Ho Hong; Hwan-Mook Kim; Byung-Zun Ann
Source:: Archives of pharmacal research 2002 v.25 no.5 pp. 600-607
ISSN:: 0253-6269
Subject:: antineoplastic activity; cytotoxicity; neoplasm cells
Abstract:: ... Two series of 2,3-diarylcyclopent-2-ene-1-ones including 2-aryl-3-(2,5-dihydroxyphenyl)cyclopent-2-ene-1-ones (2a~2f) and 3-aryl-2-(3′,4′,5′-trimethoxyphenyl)cyclopent-2-ene-1-one (3a~3j) were synthesized and evaluated for the cytotoxicity against three tumor cell lines; B16F10, HCT116 and A431. It was found that the 3,4,5-trimethoxy substituent was optimal for the bioactivity of compounds in seri ...
DOI:: 10.1007/BF02976928
: https://doi.org/10.1007/BF02976928

28. Anti-tumor Activity of Daphne mucronata Extract and its Effects on TNF-a Receptors and TNF-a Release in Cultured Human Monocytes

Author:: Hedayati, M.; Yazdanparast, R.; Fasihi, H.; Azizi, F.
Source:: Pharmaceutical biology 2003 v.41 no.3 pp. 194-198
ISSN:: 1388-0209
Subject:: Daphne; alcohols; antineoplastic activity; breast neoplasms; humans; lipopolysaccharides; mechanism of action; monocytes; oral administration; paclitaxel; plant extracts; rats; receptors; secretion; tumor necrosis factor-alpha
Abstract:: ... Oral administration of an alcohol extract (EtOH:H 2 O 1:1 v/v) of Daphne mucronata (Thymelaeaceae) to a group of breast tumor bearing rats, for more than 20 consecutive days, reduced significantly the diameter of tumor or eliminated them totally if the treatment continued for a longer time. The breast tumors were induced in rats by DMBA administration (5 mg per dose) twice a week and for 4 consecu ...
DOI:: 10.1076/phbi.41.3.194.15093
: https://doi.org/10.1076/phbi.41.3.194.15093

29. Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

Author:: Masahiro NAGASE; Jinsei OTO; Sin SUGIYAMA; Kouichi YUBE; Yoshihisa TAKAISHI; Nobuo SAKATO
Source:: Bioscience, biotechnology, and biochemistry 2003 v.67 no.9 pp. 1883-1887
ISSN:: 1347-6947
Subject:: Celastraceae; DNA fragmentation; antineoplastic activity; apoptosis; biotechnology; etoposide; humans; leukemia; triterpenoids
Abstract:: ... Celastrol, which is a triterpene purified from Celastraceae plants, has anticancer and anti-inflammatory activities. In this study we investigated to clarify whether celastrol can induce apoptosis in a human leukemia HL-60 model system. Celastrol was found to induce apoptosis, and the rank order of the potency of celastrol and its derivatives to induce internucleosomal DNA fragmentation was found ...
DOI:: 10.1271/bbb.67.1883
: https://doi.org/10.1271/bbb.67.1883

30. Bioactivity from Toona ciliata stem bark

Author:: Chowdhury, Rasheduzzaman; Hasan, Choudhury M.; Rashid, Mohammad A.
Source:: Pharmaceutical biology 2003 v.41 no.4 pp. 281-283
ISSN:: 1388-0209
Subject:: Artemia; Toona ciliata; antineoplastic activity; bark; bioassays; cytotoxicity; petroleum; potatoes; sulfates; vincristine
Abstract:: ... Studies were carried out to screen Toona ciliata M. J. Roemer (Meliaceae) for its cytotoxicity and antitumor activity. The crude extracts and a major isolate, siderin, obtained from the petroleum ether extract of T. ciliata were found to exhibit significant cytotoxicity in the brine shrimp lethality bioassay. In the potato disc bioassay, the extracts and the fractions demonstrated mild to moderate ...
DOI:: 10.1076/phbi.41.4.281.15662
: https://doi.org/10.1076/phbi.41.4.281.15662

31. Carbohydrates—The Renewable Raw Materials of High Biotechnological Value

Author:: Honnavally P. Ramesh; Rudrapatnam N. Tharanathan
Source:: Critical reviews in biotechnology 2003 v.23 no.2 pp. 149-173
ISSN:: 1549-7801
Subject:: algae; antineoplastic activity; cell walls; chronic diseases; foods; fungi; glucans; glycomics; medicine; molecular conformation; plasticity; porosity; raw materials; sugars; texture; therapeutics; water holding capacity
Abstract:: ... Carbohydrates are the potential biomolecules derived from nature. Their molecular diversity has led to a bewildering variety of species, structures and characteristics all performing a large array of functions of great significance. Biologically they are vital as message (immunological) carriers, physiologically they are useful as energy (nutritional) reserves, and technologically they are needed ...
DOI:: 10.1080/713609312
PubMed:: 12889744
: https://doi.org/10.1080/713609312

32. Cytotoxic and antitumor activities of ethanolic extracts of salt marsh plants from the lower saxonian wadden sea, southern north sea

Author:: Lellau, Thomas F.; Liebezeit, Gerd
Source:: Pharmaceutical biology 2003 v.41 no.4 pp. 293-300
ISSN:: 1388-0209
Subject:: Agrobacterium radiobacter; Artemia salina; Artemisia; Daphnia magna; Limonium vulgare; Ononis; Salicornia europaea; Trifolium fragiferum; Trifolium repens; antineoplastic activity; antineoplastic agents; bioassays; chronic toxicity; cytotoxicity; elderly; larvae; plant extracts; potatoes; salt marsh plants; screening; North Sea
Abstract:: ... Twenty-eight plant species belonging to fifteen families were subjected to a screening for cytotoxic and antitumor activities with three test organisms in six bioassays. Freshly hatched larvae and four week old adults of Artemia salina LEACH are used for the detection of acute toxic activity after 6 h and chronic toxicity after 24 h. Adult Daphnia magna STRAUS were used to establish toxic activiti ...
DOI:: 10.1076/phbi.41.4.293.15668
: https://doi.org/10.1076/phbi.41.4.293.15668

33. Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs

Author:: Hyen Joo PARK; Hyun-Jung LEE; Eun-Jin LEE; Hye Jin HWANG; Sang-Hee SHIN; Myung-Eun SUH; Choonmi KIM; Hwa Jung KIM; Eun-Kyung SEO; Sang Kook LEE
Source:: Bioscience, biotechnology, and biochemistry 2003 v.67 no.9 pp. 1944-1949
ISSN:: 1347-6947
Subject:: DNA topoisomerase; antineoplastic activity; biotechnology; colon; colorectal neoplasms; cytotoxicity; humans; kinetoplast DNA; lung neoplasms; neoplasm cells; placenta; plasmids; stomach; stomach neoplasms
Abstract:: ... A series of benz[f]indole-4,9-diones, based on the antitumor activity of 1,4-naphthoquinone, were synthesized and evaluated for their cytotoxic activity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer), and also for the inhibition of human DNA topoisomerases I and II activity in vitro. Several compounds including 2-amino-3-ethoxycarbonyl-N-m ...
DOI:: 10.1271/bbb.67.1944
: https://doi.org/10.1271/bbb.67.1944

34. Screening for antitumor activity of 11 species of Indonesian Zingiberaceae using human MCF-7 and HT-29 cancer cells

Author:: Kirana, Chandra; Record, Ian R.; McIntosh, Graeme H.; Jones, Graham P.
Source:: Pharmaceutical biology 2003 v.41 no.4 pp. 271-276
ISSN:: 1388-0209
Subject:: Curcuma aeruginosa; Kaempferia galanga; Zingiber officinale; antineoplastic activity; apoptosis; breast neoplasms; clinical trials; colorectal neoplasms; colorimetry; curcumin; ethanol; fibroblasts; humans; in vivo studies; microscopy; neoplasm cells; screening; spices; tetrazolium; Indonesia; United States
Abstract:: ... We have screened 11 important species of Zingiberaceae, used as spices and for medicinal purposes in Indonesia, for their antitumor activity using human HT-29 colon cancer and MCF-7 breast cancer cells. They were Amommum cardamomum, Curcuma aeruginosa, C. longa, C. mangga, C. xanthorrhiza, Kaempferia galanga, K. pandurata, K. rotunda, Z. aromaticum, Z. cassumunar, and Zingiber officinale. Ethanol ...
DOI:: 10.1076/phbi.41.4.271.15673
: https://doi.org/10.1076/phbi.41.4.271.15673

35. Structural Revision of Sulfated Polysaccharide B-1 Isolated from a Marine Pseudomonas Species and Its Cytotoxic Activity Against Human Cancer Cell Lines

Author:: Masahiro Matsuda; Takao Yamori; Mikihiko Naitoh; Koichi Okutani
Source:: Marine biotechnology 2003 v.5 no.1 pp. 13-19
ISSN:: 1436-2228
Subject:: DNA fragmentation; Pseudomonas; antineoplastic activity; antineoplastic agents; apoptosis; central nervous system; culture filtrates; cytotoxicity; databases; growth retardation; humans; lung neoplasms; polysaccharides
Abstract:: ... : AbstractThe structure of a sulfated polysaccharide (B-1) isolated and purified from the culture filtrate of marine Pseudomonas sp. WAK-1 was revised to have a repeating unit as follows: -2)-β-D-Galp(4SO₄)(1-4)[β-D-Glcp(1-6)]-β-D-Galp(3SO₄)(1-. B-1 was evaluated for anticancer activity using a human cancer cell line panel coupled with a drug sensitivity database. The average B-1 concentration req ...
DOI:: 10.1007/s10126-002-0046-5
: https://doi.org/10.1007/s10126-002-0046-5

36. Anti-Tumor Activity of an Enzymatically Synthesized α-1,6 Branched α-1,4-Glucan, Glycogen

Author:: Kazuo RYOYAMA; Yumi KIDACHI; Hideaki YAMAGUCHI; Hideki KAJIURA; Hiroki TAKATA
Source:: Bioscience, biotechnology, and biochemistry 2004 v.68 no.11 pp. 2332-2340
ISSN:: 1347-6947
Subject:: amylopectin; amylose; antineoplastic activity; biotechnology; dextrins; glycogen; hexabromocyclododecane; necrosis; neoplasms; nitric oxide; oral administration; polymerization
Abstract:: ... Oral administration of an enzymatically synthesized α-1,4:1,6-glycogen (ESG) at a dose of 50 μg/ml significantly prolonged the survival time of Meth A tumor-bearing mice. ESG also significantly stimulated macrophage-like cells (J774.1), leading to augmented production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α). The weight-average degree of polymerization (DPw) and the ratio of branch ...
DOI:: 10.1271/bbb.68.2332
: https://doi.org/10.1271/bbb.68.2332

37. Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus

Author:: Tomoyuki NAKAMURA; Seiichi MATSUGO; Yasuyuki UZUKA; Sumitaka MATSUO; Hirokazu KAWAGISHI
Source:: Bioscience, biotechnology, and biochemistry 2004 v.68 no.4 pp. 868-872
ISSN:: 1347-6947
Subject:: Phellinus linteus; antineoplastic activity; biotechnology; fractionation; glucans; mycelium; pH
Abstract:: ... All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein–glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0. This protein–glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its ¹³C- and ¹H-NMR data showed that the main glucan part of the c ...
DOI:: 10.1271/bbb.68.868
: https://doi.org/10.1271/bbb.68.868

38. Hot off the press

Author:: Robert A. Hill; Andrew Sutherland
Source:: Natural product reports 2004 v.21 no.4 pp. H13
ISSN:: 1460-4752
Subject:: antimalarials; antineoplastic activity; chemistry; diterpenoids
Abstract:: ... A personal selection of 36 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as bielschowskyin which has a novel diterpenoid framework and shows antimalarial and anticancer activity. ...
DOI:: 10.1039/b410028j
: https://doi.org/10.1039/b410028j

39. Differential cytotoxic effects ofAnnona squamosa seed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione

Author:: B. V. V. Pardhasaradhi; Madhurima Reddy; A. Mubarak Ali; A. Leela Kumari; Ashok Khar
Source:: Journal of biosciences 2005 v.30 no.2 pp. 237-244
ISSN:: 0250-5991
Subject:: Annona reticulata; Annona squamosa; DNA fragmentation; acetogenins; antineoplastic activity; apoptosis; cell growth; cytotoxicity; glutathione; human cell lines; humans; neoplasm cells; oxidative stress; seed extracts; seeds; staining
Abstract:: ... Annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. In this study, organic and aqueous extracts from the defatted seeds ofAnnona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. While organic and aqueous extracts induced apoptosis ...
DOI:: 10.1007/BF02703704
: https://doi.org/10.1007/BF02703704

40. Effect of Molecular Mass on Antitumor Activity of Heteropolysaccharide from Poria cocos

Author:: Lina ZHANG; Li CHEN; Xiaojuan XU; Fanbo ZENG; Peter Chi Keung CHEUNG
Source:: Bioscience, biotechnology, and biochemistry 2005 v.69 no.3 pp. 631-634
ISSN:: 1347-6947
Subject:: Poria; antineoplastic activity; biotechnology; body weight; fluorouracil; gel chromatography; lethal dose 50; molecular weight; water solubility
Abstract:: ... A water-soluble heteropolysaccharide ac-PCM0 from Poria cocos was successfully fractionated using a preparative size exclusion chromatography (SEC) column, and their weight-average molecular mass (M w) was characterized by analytical SEC combined with laser light scattering (SEC-LLS). The results indicate that the fractions having relatively high M w exhibited higher inhibition ratio in vivo antit ...
DOI:: 10.1271/bbb.69.631
: https://doi.org/10.1271/bbb.69.631

41. Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae

Author:: Yuko IMAMURA; Masashi YUKAWA; Ken-ichi KIMURA; Hidetoshi TAKAHASHI; Yoshihiro SUZUKI; Makoto OJIKA; Youji SAKAGAMI; Eiko TSUCHIYA
Source:: Bioscience, biotechnology, and biochemistry 2005 v.69 no.11 pp. 2213-2218
ISSN:: 1347-6947
Subject:: Saccharomyces cerevisiae; Streptomyces griseus; antibiotics; antineoplastic activity; biotechnology; cytotoxicity; inhibitory concentration 50; mitochondria; multiple drug resistance; yeasts
Abstract:: ... Fredericamycin A (FMA) is an antibiotic product of Streptomyces griseus that exhibits modest antitumor activity in vivo and in vitro, but, its functions in vivo are poorly understood. We identified this compound as an inducer of G1 arrest in the yeast, Saccharomyces cerevisiae. FMA exhibits an IC50 of 24 nM towards the growth of a disruptant of multi-drug resistance genes, W303-MLC30, and its cyto ...
DOI:: 10.1271/bbb.69.2213
: https://doi.org/10.1271/bbb.69.2213

42. Immunostimulatory Effects of a Polysaccharide-Rich Substance with Antitumor Activity Isolated from Black Currant (Ribes nigrum L.)

Author:: Ryoji TAKATA; Reiko YAMAMOTO; Takaaki YANAI; Tomonori KONNO; Toshiyuki OKUBO
Source:: Bioscience, biotechnology, and biochemistry 2005 v.69 no.11 pp. 2042-2050
ISSN:: 1347-6947
Subject:: Ribes nigrum; antineoplastic activity; arabinose; biotechnology; black currants; cytotoxicity; fruit juices; galactose; glucose; immunostimulants; interleukin-10; interleukin-2; interleukin-4; macrophage activation; mannose; neoplasms; oral administration; polysaccharides; rhamnose; splenocytes; xylose
Abstract:: ... The fruit juice of black currant was found to contain a polysaccharide-rich substance, which was designated cassis polysaccharide (CAPS), with macrophage-stimulating activity. Especially, its interleukin (IL)-1β-inducing activity was remarkably high, compared with other fruit juice preparations. CAPS was found to consist of rhamnose, mannose, arabinose, galactose, xylose, and glucose in a molar ra ...
DOI:: 10.1271/bbb.69.2042
: https://doi.org/10.1271/bbb.69.2042

43. Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

Author:: Yaw Kai YanPermanent address: Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Republic of Singapore. E-mail: ykyan@nie.edu.sg; Michael Melchart; Abraha Habtemariam; Peter J. Sadler
Source:: Chemical communications 2005 v. no.38 pp. 4764-4776
ISSN:: 1364-548X
Subject:: adverse effects; amino acids; antineoplastic activity; aromatic hydrocarbons; chemical reactions; clinical trials; ligands; medicine; nucleotides; ruthenium; thermodynamics; water solubility
Abstract:: ... Our work has shown that certain ruthenium(ii) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on ami ...
DOI:: 10.1039/b508531b
: https://doi.org/10.1039/b508531b

44. Using genomics to deliver natural products from symbiotic bacteria

Author:: Jon Clardy
Source:: Genome biology 2005 v.6 no.9 pp. 976
ISSN:: 1474-760X
Subject:: animals; antineoplastic activity; bacteria; genes; genomics; microsymbionts
Abstract:: ... The availability of some natural products with promising anticancer activity has been limited because they are synthesized by symbiotic bacteria associated with specific animals. Recent research has identified the clusters of bacterial genes responsible for their synthesis, so that the molecules can be synthesized in alternative, easily cultured bacteria. ...
DOI:: 10.1186/gb-2005-6-9-232
PubMed:: 16168093
PubMed Central:: PMC1242202
: https://doi.org/10.1186/gb-2005-6-9-232

45. Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice

Author:: Yuji NONAKA; Hiroshi SHIBATA; Masaaki NAKAI; Hiroshi KURIHARA; Hiroko ISHIBASHI; Yoshinobu KISO; Takaharu TANAKA; Hideyo YAMAGUCHI; Shigeru ABE
Source:: Bioscience, biotechnology, and biochemistry 2006 v.70 no.9 pp. 2028-2034
ISSN:: 1347-6947
Subject:: Ganoderma lucidum; antineoplastic activity; biotechnology; diet; ingestion; interferon-gamma; longevity; lymph; sarcoma
Abstract:: ... We investigated the anti-tumor effects of a dry powder preparation of the antlered form of Ganoderma lucidum (G. lucidum AF, rokkaku-reishi in Japanese), a variant type of G. lucidum, not only in allogeneic Sarcoma 180-bearing ddY mice, but also in syngeneic MM 46-bearing C3H/He mice. G. lucidum AF inhibited tumor growth and elongated the life span when orally administered to mice by free-feeding ...
DOI:: 10.1271/bbb.50509
: https://doi.org/10.1271/bbb.50509

46. Biological activity of vanadium compounds

Author:: Anna Goc
Source:: Open life sciences 2006 v.1 no.3 pp. 314-332
ISSN:: 2391-5412
Subject:: absorption; adverse effects; antineoplastic activity; apoptosis; carbohydrates; cardiomyopathy; chemical derivatives; chemical structure; cholesteremic effect; diabetes; geometry; glycemic control; hyperglycemia; hyperlipidemia; insulin; kidney diseases; lipid metabolism; retinal diseases; toxicity; vanadium
Abstract:: ... Vanadium compounds are characterised by a broad spectrum of action in vivo and in vitro. Their insulin-mimetic activity is manifested in their ability to normalize changes observed in both clinical and experimental diabetes (i.e. hyperglycaemia, hyperlipidaemia, lowered cell sensitivity to insulin) through the regulation of carbohydrate and lipid metabolism and the removal of secondary symptoms of ...
DOI:: 10.2478/s11535-006-0029-z
: https://doi.org/10.2478/s11535-006-0029-z

47. Genes of multidrug resistance in haematological malignancies

Author:: Jozef Hatok; Peter Račay; Jan Hudeček; Dušan Dobrota
Source:: Biologia 2006 v.61 no.3 pp. 247-256
ISSN:: 1336-9563
Subject:: P-glycoproteins; antineoplastic activity; antineoplastic agents; cytotoxicity; drug therapy; enzymes; genes; multiple drug resistance; neoplasm cells; neoplasms; patients; surveys
Abstract:: ... Since the early 1970s, multiple drug resistance has been known to exist in cancer cells and is thought to be attributable to a membrane-bound, energy-dependent pump protein (P-glycoprotein [P-gp]) capable of extruding various related and unrelated chemotherapeutic drugs. The development of refractory disease in haematological malignancies is frequently associated with the expression of one or seve ...
DOI:: 10.2478/s11756-006-0046-4
: https://doi.org/10.2478/s11756-006-0046-4

48. Induction of a Ribotoxic Stress Response That Stimulates Stress-Activated Protein Kinases by 13-Deoxytedanolide, an Antitumor Marine Macrolide

Author:: Kun-Hyung LEE; Shinichi NISHIMURA; Shigeki MATSUNAGA; Nobuhiro FUSETANI; Hidenori ICHIJO; Sueharu HORINOUCHI; Minoru YOSHIDA
Source:: Bioscience, biotechnology, and biochemistry 2006 v.70 no.1 pp. 161-171
ISSN:: 1347-6947
Subject:: Porifera; antineoplastic activity; apoptosis; biotechnology; drugs; gene expression; macrolides; mice; mitogen-activated protein kinase; mutants; plasminogen activator inhibitors; polypeptides; protein synthesis; ribosomes; stress response; temperature; transforming growth factor beta; yeasts
Abstract:: ... 13-Deoxytedanolide is a structurally unique macrolide with strong antitumor activity isolated from a marine sponge. Recently, we showed that 13-deoxytedanolide bound to the large subunit of the yeast ribosome and inhibited polypeptide elongation in vitro, but the mechanism by which it exerts antitumor activity is still unknown. Here we show that 13-deoxytedanolide strongly induces plasminogen acti ...
DOI:: 10.1271/bbb.70.161
: https://doi.org/10.1271/bbb.70.161

49. Isolation of methyl gallate and evaluation of the antibacterial and antineoplastic activity of some extracts ofKlainedoxa gabonensis Pierre ex Engl.

Author:: A. Ekouya; B. G. Itoua; A. Ouabonzi; J. M. Ouamba
Source:: Phytothérapie 2006 v.4 no.3 pp. 117-120
ISSN:: 1624-8597
Subject:: antineoplastic activity; chemical analysis; dermatitis; screening
Abstract:: ... Klainedoxa gabonensis Pierre ex Engl. is a plant that traditional Congolese therapists use for treating many diseases. It is particularly used for a disease locally known as “mwandza” dermatitis, for which modern treatments are still unsuccessful. A pharmacological screening revealed antibacterial and antitumoral activities. The chemical analysis of an organic extract isolated the methyl gallate. ...
DOI:: 10.1007/s10298-006-0164-8
: https://doi.org/10.1007/s10298-006-0164-8

50. The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

Author:: Mamta Dadwal; Renu Mohan; Dulal Panda; Shaikh M. Mobin; Irishi N. N. Namboothiri
Source:: Chemical communications 2006 v. no.3 pp. 338-340
ISSN:: 1364-548X
Subject:: alkenes; ambient temperature; antineoplastic activity; cell proliferation; chemical reactions; human cell lines; imidazole; lithium chloride; tubulin
Abstract:: ... The Morita–Baylis–Hillman (MBH) adducts of β-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin. ...
DOI:: 10.1039/b512267h
: https://doi.org/10.1039/b512267h

51. A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen

Author:: Schietinger, Andrea; Philip, Mary; Yoshida, Barbara A.; Azadi, Parastoo; Liu, Hui; Meredith, Stephen C.; Schreiber, Hans
Source:: Science 2006 v.314 no.5797 pp. 304-308
ISSN:: 0036-8075
Subject:: antineoplastic activity; epitopes; genes; monoclonal antibodies; mutants; neoplasms; somatic mutation; therapeutics; transmembrane proteins
Abstract:: ... Monoclonal antibodies have become important therapeutic agents against certain cancers. Many tumor-specific antigens are mutant proteins that are predominantly intracellular and thus not readily accessible to monoclonal antibodies. We found that a wild-type transmembrane protein could be transformed into a tumor-specific antigen. A somatic mutation in the chaperone gene Cosmc abolished function of ...
DOI:: 10.1126/science.1129200
: https://doi.org/10.1126/science.1129200

52. Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy

Author:: Thorne, Steve H.; Negrin, Robert S.; Contag, Christopher H.
Source:: Science 2006 v.311 no.5768 pp. 1780-1784
ISSN:: 0036-8075
Subject:: Vaccinia virus; animal models; antineoplastic activity; image analysis; neoplasms; synergism; therapeutics; viruses
Abstract:: ... Targeted biological therapies hold tremendous potential for treatment of cancer, yet their use has been limited by constraints on delivery and effective tumor targeting. We combined an immune effector cell population [cytokine-induced killer (CIK) cells] with an oncolytic viral therapy to achieve directed delivery to, and regression of, tumors in both immunodeficient and immunocompetent mouse mode ...
DOI:: 10.1126/science.1121411
: https://doi.org/10.1126/science.1121411

53. Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors

Author:: Shaked, Yuval; Ciarrocchi, Alessia; Franco, Marcela; Lee, Christina R.; Man, Shan; Cheung, Alison M.; Hicklin, Daniel J.; Chaplin, David; Foster, F. Stuart; Benezra, Robert; Kerbel, Robert S.
Source:: Science 2006 v.313 no.5794 pp. 1785-1787
ISSN:: 0036-8075
Subject:: angiogenesis; animal disease models; antineoplastic activity; blood flow; blood vessels; bone marrow cells; disease control; drug synergism; drug therapy; drugs; endothelial cells; genetic engineering; mechanistic models; mice; neoplasms; stem cells
Abstract:: ... The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads to an acute mobilization of CEPs, which home to the viable tumor rim that characteristically remain ...
DOI:: 10.1126/science.1127592
: https://doi.org/10.1126/science.1127592

54. Two fucoidans in the holdfast of cultivated Laminaria japonica

Author:: Tomohiro Ozawa; Jynji Yamamoto; Takashi Yamagishi; Noriyuki Yamazaki; Makoto Nishizawa
Source:: Natural medicines 2006 v.60 no.3 pp. 236-239
ISSN:: 1340-3443
Subject:: Saccharina japonica; Saccharina sculpera; adenocarcinoma; antineoplastic activity; fronds; fucoidan; fucose; mice; sulfates
Abstract:: ... Two fucoidans have been isolated from the holdfast of cultivated Laminaira japonica. One (L-fucoidan) is rich in fucose and sulfate; the other (GA-fucoidan) is rich in uronate. L-fucoidan was found in the fronds of L. japonica (cultivated and wild), L. angustata, and Kjellmaniella crassifolia whereas GA-fucoidan was not detected in these fronds and may be a fucoidan specific to the holdfast. These ...
DOI:: 10.1007/s11418-006-0046-2
: https://doi.org/10.1007/s11418-006-0046-2

55. Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis

Author:: Liu, Tao; Tee, Andrew E.L.; Porro, Antonio; Smith, Stewart A.; Dwarte, Tanya; Liu, Pei Yan; Iraci, Nunzio; Sekyere, Eric; Haber, Michelle; Norris, Murray D.; Diolaiti, Daniel; Della Valle, Giuliano; Perini, Giovanni; Marshall, Glenn M.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.47 pp. 18682-18687
ISSN:: 0027-8424
Subject:: antineoplastic activity; antineoplastic agents; apoptosis; binding sites; breast neoplasms; carcinogenesis; cell differentiation; cell proliferation; chromatin; complementary DNA; crosslinking; histone deacetylase; mice; microarray technology; neoplasm cells; oncogene proteins; precipitin tests; protein-glutamine gamma-glutamyltransferase; therapeutics; transactivators; transcription (genetics); transgenic animals; tumor suppressor genes
Abstract:: ... Histone deacetylase (HDAC) inhibitors reactivate tumor suppressor gene transcription; induce cancer cell differentiation, growth arrest, and programmed cell death; and are among the most promising new classes of anticancer drugs. Myc oncoproteins can block cell differentiation and promote cell proliferation and malignant transformation, in some cases by modulating target gene transcription. Here, ...
DOI:: 10.1073/pnas.0705524104
PubMed:: 18003922
PubMed Central:: PMC2141837
: https://doi.org/10.1073/pnas.0705524104

56. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Author:: Manfredi, Mark G.; Ecsedy, Jeffrey A.; Meetze, Kristan A.; Balani, Suresh K.; Burenkova, Olga; Chen, Wei; Galvin, Katherine M.; Hoar, Kara M.; Huck, Jessica J.; LeRoy, Patrick J.; Ray, Emily T.; Sells, Todd B.; Stringer, Bradley; Stroud, Stephen G.; Vos, Tricia J.; Weatherhead, Gabriel S.; Wysong, Deborah R.; Zhang, Mengkun; Bolen, Joseph B.; Claiborne, Christopher F.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.10 pp. 4106-4111
ISSN:: 0027-8424
Subject:: antineoplastic activity; apoptosis; clinical trials; cultured cells; growth retardation; humans; mice; mitosis; neoplasm cells; neoplasms; non-specific serine/threonine protein kinase; oral administration; phenotype
Abstract:: ... Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and progression. MLN8054 is a selective small-molecule Aurora A kinase inhibitor that has entered Phase I clinical trials for advanced solid tumors. MLN8054 inhibits recombinant Aurora A kinase activity in vitro and is selective for Aurora A over ...
DOI:: 10.1073/pnas.0608798104
PubMed:: 17360485
PubMed Central:: PMC1820716
: https://doi.org/10.1073/pnas.0608798104

57. Antitumor and Cytotoxic Effects of Phyllanthus polyphyllus on Ehrlich Ascites Carcinoma and Human Cancer Cell Lines

Author:: Balasubramanian RAJKAPOOR; Marimuthu SANKARI; Mohan SUMITHRA; Jayaraman ANBU; Narayanaswamy HARIKRISHNAN; Manavalan GOBINATH; Venkatesan SUBA; Ramachandran BALAJI
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.9 pp. 2177-2183
ISSN:: 1347-6947
Subject:: Phyllanthus; antineoplastic activity; ascites; biotechnology; breast neoplasms; carcinoma; catalase; colorectal neoplasms; cytotoxicity; dose response; glutathione peroxidase; glutathione transferase; humans; lipid peroxidation; liver neoplasms; methanol; models; neoplasm cells; oral administration; superoxide dismutase
Abstract:: ... To evaluate the antitumor and cytotoxic activity of methanol extract of Phyllanthus polyphyllus (MPP) in mice and human cancer cell lines, the antitumor activity of MPP was evaluated against an Ehrlich ascites carcinoma (EAC) tumor model. The activity was assessed using survival time, hematological studies, lipid peroxidation (LPO), antioxidant enzymes such as superoxide dismutase (SOD), catalase, ...
DOI:: 10.1271/bbb.70149
: https://doi.org/10.1271/bbb.70149

58. Antiviral activity of oxidized polyamines

Author:: Bachrach, U.
Source:: Amino acids 2007 v.33 no.2 pp. 267-272
ISSN:: 0939-4451
Subject:: Alfalfa mosaic virus; DNA; Newcastle disease; Orthomyxoviridae; Potato virus X; Tobacco mosaic virus; acrolein; animal viruses; antineoplastic activity; antiviral properties; bacteria; bacteriophages; blood serum; hydrogen peroxide; influenza; microbial growth; oxidation; plant growth; plant viruses; polyamines
Abstract:: ... Polyamines, oxidized by serum amine oxidase, yield aminoaldehydes and hydrogen peroxide. Acrolein may be formed from the aminoaldehydes by a spontaneous β-elimination process. These oxidation products “oxidized polyamines” inhibit bacterial growth and exhibit anticancer activity. The antimicrobial activity of oxidized polyamines is not limited to bacteria; and the inactivation of bacterial viruses ...
DOI:: 10.1007/s00726-007-0535-y
PubMed:: 17429570
: https://doi.org/10.1007/s00726-007-0535-y

59. Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth

Author:: Loeffler, Markus; Le'Negrate, Gaelle; Krajewska, Maryla; Reed, John C.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.31 pp. 12879-12883
ISSN:: 0027-8424
Subject:: Salmonella Typhimurium; adverse effects; antineoplastic activity; bacteria; biopharmaceuticals; cytokines; genes; genetically engineered microorganisms; growth retardation; humans; intravenous injection; metastasis; mice; models; neoplasm cells; neoplasms; receptors; toxicity; viruses
Abstract:: ... Intravenously administered bacteria reportedly accumulate in tumors. Furthermore, systemic administration of attenuated Salmonella typhimurium has little or no significant side-effects in humans. Consequently, we engineered such bacteria to improve their oncolytic activity by stably inserting a gene encoding LIGHT, a cytokine known to promote tumor rejection. Unlike control bacteria, attenuated S. ...
DOI:: 10.1073/pnas.0701959104
PubMed:: 17652173
PubMed Central:: PMC1937560
: https://doi.org/10.1073/pnas.0701959104

60. Biologically active, synthetic ion transporters

Author:: George W. Gokel; I. Alexandru Carasel
Source:: Chemical Society reviews 2007 v.36 no.2 pp. 378-389
ISSN:: 1460-4744
Subject:: antineoplastic activity; ion channels; models; transporters
Abstract:: ... The compelling chemical goal of modeling protein channel behavior has led to synthetic compounds that are true ion channels. Although they largely lack the selectivity and sophistication of highly evolved proteins, they successfully perform a variety of biological functions. This tutorial review describes these novel structures and their activity in living systems. Different channel structures sho ...
DOI:: 10.1039/b605910b
: https://doi.org/10.1039/b605910b

61. Cloning, expression, and antitumor activity of recombinant protein of curcin

Author:: Luo, M. J.; Liu, W. X.; Yang, X. Y.; Xu, Y.; Yan, F.; Huang, P.; Chen, F.
Source:: Russian journal of plant physiology 2007 v.54 no.2 pp. 202-206
ISSN:: 1021-4437
Subject:: Escherichia coli; Jatropha curcas; affinity chromatography; antineoplastic activity; neoplasm cells; purification methods; recombinant proteins; seeds
Abstract:: ... Curcin, a protein isolated from the seeds of Jatropha curcas can be used as a cell-killing agent. To elaborate the purification methods and investigate the antitumor activity of the recombinant protein, the fragment encoding the mature protein of curcin was inserted into E. coli strain M15 and the recombinant strain was induced to express by the optimum inducer (0.5 mM isopropyl-β-D-thiogalactopyr ...
DOI:: 10.1134/S1021443707020070
: https://doi.org/10.1134/S1021443707020070

62. Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

Author:: Stommel, Jayne M.; Kimmelman, Alec C.; Ying, Haoqiang; Nabioullin, Roustem; Ponugoti, Aditya H.; Wiedemeyer, Ruprecht; Stegh, Alexander H.; Bradner, James E.; Ligon, Keith L.; Brennan, Cameron; Chin, Lynda; DePinho, Ronald A.
Source:: Science 2007 v.318 no.5848 pp. 287-290
ISSN:: 0036-8075
Subject:: RNA interference; antineoplastic activity; brain; cell viability; neoplasm cells; neoplasms; phosphatidylinositol 3-kinase; receptor protein-tyrosine kinase; signal transduction; therapeutics
Abstract:: ... Targeted therapies that inhibit receptor tyrosine kinases (RTKs) and the downstream phosphatidylinositol 3-kinase (PI3K) signaling pathway have shown promising anticancer activity, but their efficacy in the brain tumor glioblastoma multiforme (GBM) and other solid tumors has been modest. We hypothesized that multiple RTKs are coactivated in these tumors and that redundant inputs drive and maintain ...
DOI:: 10.1126/science.1142946
: https://doi.org/10.1126/science.1142946

63. Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

Author:: Makino, Masatomo; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Asamizu, Shumpei; Onaka, Hiroyasu; Nagano, Shingo
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.28 pp. 11591-11596
ISSN:: 0027-8424
Subject:: Streptomyces; X-ray diffraction; active sites; alkaloids; antineoplastic activity; biosynthesis; crystal structure; cytochrome P-450; cytochrome-c peroxidase; decarboxylation; heme; hydrogen bonding; skeleton
Abstract:: ... Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in staurosporine biosynthesis is the formation of the indolocarbazole core by intramolecular C-C bond formation and oxidative decarboxylation of chromopyrrolic acid (CPA) catalyzed by cytochrome P450 StaP (StaP, CYP245A1). In this study, we ...
DOI:: 10.1073/pnas.0702946104
PubMed:: 17606921
PubMed Central:: PMC1913897
: https://doi.org/10.1073/pnas.0702946104

64. Endogenous IL-12 triggers an antiangiogenic program in melanoma cells

Author:: Airoldi, Irma; Di Carlo, Emma; Cocco, Claudia; Taverniti, Giuseppe; D'Antuono, Tommaso; Ognio, Emanuela; Watanabe, Morihiro; Ribatti, Domenico; Pistoia, Vito
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.10 pp. 3996-4001
ISSN:: 0027-8424
Subject:: T-lymphocytes; antineoplastic activity; apoptosis; blood serum; cytotoxicity; gene expression regulation; genes; humans; hydrodynamics; interferon-gamma; interleukin-12; melanoma; mice; natural killer cells; neoplasm cells; phenotype
Abstract:: ... The IL12RB2 gene acts as a tumor suppressor in human B cell malignancies. Indeed, Il12rb2 knockout (KO) mice develop spontaneously B cell tumors, but also lung epithelial tumors. This latter phenotype may be related to (i) impairment of host IL-12-mediated immunosurveillance and/or (ii) IL-12 inability to inhibit directly the growth of IL-12 unresponsive malignant cells. To address this issue, we ...
DOI:: 10.1073/pnas.0609028104
PubMed:: 17360466
PubMed Central:: PMC1820697
: https://doi.org/10.1073/pnas.0609028104

65. Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential

Author:: Lentini, A.; Forni, C.; Provenzano, B.; Beninati, S.
Source:: Amino acids 2007 v.32 no.1 pp. 95-100
ISSN:: 0939-4451
Subject:: antineoplastic activity; cell proliferation; chemoprevention; melanoma; metastasis; mice; naringenin; neoplasm cells; oral administration; protein-glutamine gamma-glutamyltransferase; spermidine; spermine
Abstract:: ... The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated. NG or HP treatment of melanoma cells produced a remarkable reduction of cell proliferation, paralleled with both the lowering of the intracellular levels of polyamine, spermidine and spermine and the enhancement of tra ...
DOI:: 10.1007/s00726-006-0304-3
PubMed:: 16699821
: https://doi.org/10.1007/s00726-006-0304-3

66. Evaluation of Nutritional Availability and Anti-Tumor Activity of Selenium Contained in Selenium-Enriched Kaiware Radish Sprouts

Author:: Munehiro YOSHIDA; Toshihide OKADA; Yûichi NAMIKAWA; Yoshimi MATSUZAKI; Toshimasa NISHIYAMA; Kenji FUKUNAGA
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.9 pp. 2198-2205
ISSN:: 1347-6947
Subject:: 1,2-dimethylhydrazine; antineoplastic activity; biotechnology; blood serum; colon; diet; glutathione peroxidase; liver; males; radishes; selenium; sodium selenite; weanlings
Abstract:: ... We estimated the nutritional availability of selenium (Se) in Se-enriched Kaiware radish sprouts (SeRS) by the tissue Se deposition and glutathione peroxidase (GPX) activity of rats administered the sprouts, and examined the effect of SeRS on the formation of aberrant crypt foci (ACF) in the colon of mice administered 1,2-dimethylhydrazine (DMH) to evaluate anti-tumor activity. Male weanling Wista ...
DOI:: 10.1271/bbb.70158
: https://doi.org/10.1271/bbb.70158

67. First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol

Author:: Takuya SUGAHARA; Satoshi YAMAUCHI; Ai KONDO; Fumi OHNO; Siori TOMINAGA; Yuki NAKASHIMA; Taro KISHIDA; Koichi AKIYAMA; Masafumi MARUYAMA
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.12 pp. 2962-2968
ISSN:: 1347-6947
Subject:: antineoplastic activity; cytotoxicity; enantiomers; immunoglobulin M; immunosuppression; stereoselective synthesis
Abstract:: ... The first stereoselective synthesis of meso-secoisolariciresinol is reported. A comparison of the cytotoxic and immunosuppressive activity between meso-secoisolariciresinol and optically active secoisolariciresinols was similarly performed for the first time. Both enantiomers of secoisolariciresinol accelerated IgM production, although meso-secoisolariciresinol did not affect IgM production. Only ...
DOI:: 10.1271/bbb.70358
: https://doi.org/10.1271/bbb.70358

68. Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt

Author:: Hohla, Florian; Schally, Andrew V.; Kanashiro, Celia A.; Buchholz, Stefan; Baker, Benjamin; Kannadka, Chandrika; Moder, Angelika; Aigner, Elmar; Datz, Christian; Halmos, Gabor
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.47 pp. 18671-18676
ISSN:: 0027-8424
Subject:: Western blotting; antagonists; antineoplastic activity; bombesin; breast neoplasms; gastrin-releasing peptide; growth retardation; human growth; in vitro studies; lung neoplasms; mice; receptors; tetrazolium
Abstract:: ... Bombesin (BN) or gastrin-releasing peptide (GRP) can stimulate the growth of neoplasms such as breast cancer and small-cell lung carcinoma (SCLC). Antagonists of BN/GRP have been shown to inhibit these cancers. We evaluated whether antagonists of BN/GRP can suppress the growth of human non-SCLC (NSCLC) xenografted into nude mice. The effect of the administration of BN/GRP antagonist RC-3940-II on ...
DOI:: 10.1073/pnas.0709455104
PubMed:: 18003891
PubMed Central:: PMC2141835
: https://doi.org/10.1073/pnas.0709455104

69. Hydroxymethylfurfural: an enemy or a friendly xenobiotic? A bioanalytical approach

Author:: Michail, K.; Matzi, V.; Maier, A.; Herwig, R.; Greilberger, J.; Juan, H.; Kunert, O.; Wintersteiger, R.
Source:: Analytical and bioanalytical chemistry 2007 v.387 no.8 pp. 2801-2814
ISSN:: 1618-2642
Subject:: Maillard reaction; antineoplastic activity; clinical trials; derivatization; high performance liquid chromatography; humans; hydroxymethylfurfural; models; mutagenicity; neoplasms; patients; pharmacokinetics; solid phase extraction; stereoisomers
Abstract:: ... Hydroxymethylfurfural (HMF), a well-known heterocyclic Maillard reaction product, has often been studied for its potential toxic, mutagenic, and carcinogenic effects. Recent clinical studies, however, have strongly suggested that HMF might have exciting antitumor potential. We report on the development and validation of a bioanalytical assay for HMF that could be suitable as a basis for pharmacoki ...
DOI:: 10.1007/s00216-007-1121-6
PubMed:: 17377781
: https://doi.org/10.1007/s00216-007-1121-6

70. Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis

Author:: Hansen, Bjarne G.; Kliebenstein, Daniel J.; Halkier, Barbara A.
Source:: Plant journal 2007 v.50 no.5 pp. 902-910
ISSN:: 0960-7412
Subject:: Arabidopsis; Brassica; antineoplastic activity; biosynthesis; breeding; enriched foods; enzymes; functional foods; gene overexpression; glucosinolates; isothiocyanates; knockout mutants; recombinant proteins; seeds; vegetable crops; vegetables
Abstract:: ... The cancer-preventive activity of cruciferous vegetables is commonly attributed to isothiocyanates resulting from the breakdown of the natural products glucosinolates (GSLs). Sulforaphane, the isothiocyanate derived from 4-methylsulfinylbutyl GSL, is thought to be the major agent conferring cancer-preventive properties, whereas the isothiocyanate of 4-methylthiobutyl GSL does not have the same act ...
DOI:: 10.1111/j.1365-313X.2007.03101.x
PubMed:: 17461789
: https://doi.org/10.1111/j.1365-313X.2007.03101.x

71. Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

Author:: Zhang, Yujian; Xiang, Laiman; Hassan, Raffit; Pastan, Ira
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.43 pp. 17099-17104
ISSN:: 0027-8424
Subject:: Pseudomonas; antibodies; antigens; antineoplastic activity; drug resistance; drug therapy; endothelial cells; exotoxins; extracellular space; lymphoma; mice; paclitaxel; recombinant fusion proteins
Abstract:: ... Recombinant immunotoxins are chimeric proteins composed of the Fv portion of a tumor-specific antibody fused to a toxin. SS1P (CAT-5001) is an immunotoxin composed of an antimesothelin Fv fused to a 38-kDa portion of Pseudomonas exotoxin A. Immunotoxins have been shown to be active in lymphomas and leukemias, but are much less active against solid tumors. We recently reported that Taxol and other ...
DOI:: 10.1073/pnas.0708101104
PubMed:: 17940013
PubMed Central:: PMC2040446
: https://doi.org/10.1073/pnas.0708101104

72. Improvement of the Antitumor Activity of Black Currant Polysaccharide by an Enzymatic Treatment

Author:: Ryoji TAKATA; Takaaki YANAI; Reiko YAMAMOTO; Tomonori KONNO
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.5 pp. 1342-1344
ISSN:: 1347-6947
Subject:: Aspergillus oryzae; antineoplastic activity; biotechnology; black currants; carcinoma; enzymatic treatment; immunostimulants; polysaccharides
Abstract:: ... A polysaccharide-rich substance isolated from black currant, named cassis polysaccharide (CAPS), was partially digested with β-galactosidase from Aspergillus oryzae and its immunostimulatory activity was investigated. The in vitro cytokine-inducing effect of CAPS on RAW264 cells was gradually decreased along with lowering of the average MW of CAPS. In vivo, partially digested CAPS with a mean MW o ...
DOI:: 10.1271/bbb.60725
: https://doi.org/10.1271/bbb.60725

73. In vitro antioxidative and anticancer activities of tea glycoprotein in green tea

Author:: Nie, Shaoping; Xie, Mingyong; Zhou, Peng; Cao, Shuwen
Source:: European food research & technology 2007 v.224 no.4 pp. 437-442
ISSN:: 1438-2377
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; autoxidation; beta-carotene; colorectal neoplasms; decolorization; food research; gel chromatography; glycoproteins; green tea; linoleic acid; pyrogallol
Abstract:: ... In this paper, the antioxidative and anticancer activities of tea glycoprotein (TGP) in green tea were studied. TGP was extracted from coarse old green tea and purified by Sephadex G-100 gel filtration, and its purity was determined by high performance gel permeation chromatography (HPGPC). The antioxidative activity of the TGP was evaluated by determining the change of the values of the heat-indu ...
DOI:: 10.1007/s00217-006-0324-y
: https://doi.org/10.1007/s00217-006-0324-y

74. Induction of apoptosis by immature fruits of Prunus salicina Lindl. cv. Soldam in MDA-MB-231 human breast cancer cells

Author:: Mi Hee Yu; Hyo Gwon Im; Syng-Ook Lee; Chang Sung; Dong-Cheol Park; In-Seon Lee
Source:: International journal of food sciences and nutrition 2007 v.58 no.1 pp. 42-53
ISSN:: 1465-3478
Subject:: Prunus salicina; acetone; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; caspase-9; cytotoxicity; fruits; hematopoiesis; humans; nutrition; osteoporosis; risk
Abstract:: ... The goal of this study was to evaluate the anticancer effect of Prunus salicina Lindl. cv. Soldam at three maturity stages (immature, midmature and mature stages). Previous studies have shown that this fruit (plums) possesses hematopoiesis effects, prevents osteoporosis and has anti-mutagenic effects. An acetone extract of immature P. salicina Lindl. cv. Soldam fruit contained higher levels of tot ...
DOI:: 10.1080/09637480601121938
: https://doi.org/10.1080/09637480601121938

75. Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

Author:: Nobuhiro ABURAI; Yasuaki ESUMI; Hiroyuki KOSHINO; Naoyuki NISHIZAWA; Ken-ichi KIMURA
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.8 pp. 2061-2064
ISSN:: 1347-6947
Subject:: antineoplastic activity; biotechnology; cytotoxicity; histone deacetylase; humans; leukemia; linoleic acid; methanol; millets; prostatic neoplasms
Abstract:: ... Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC₅₀=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC₅₀=68 μM) and prostate cancer LNCaP cells (IC₅₀=193 μM). Millet containing linoleic acid might have anti-tumor activity. ...
DOI:: 10.1271/bbb.70068
: https://doi.org/10.1271/bbb.70068

76. Isolation and partial characterization of pigment-like antibiotics produced by a new strain of Streptosporangium isolated from an Algerian soil

Author:: Boudjella, H.; Bouti, K.; Zitouni, A.; Mathieu, F.; Lebrihi, A.; Sabaou, N.
Source:: Journal of applied microbiology 2007 v.103 no.1 pp. 228-236
ISSN:: 1364-5072
Subject:: Gram-positive bacteria; Streptosporangium carneum; antibacterial properties; antibiotics; antineoplastic activity; aromatic compounds; chemotaxonomy; chromatography; culture media; drug therapy; neoplasms; nuclear magnetic resonance spectroscopy; nucleotide sequences; phylogeny; ribosomal DNA; soil
Abstract:: ... Identification of a new actinomycete strain Sg3, belonging to the genus Streptosporangium and partial characterization of the produced antibacterial activities. The strain Sg3 was isolated from an Algerian Saharan soil and identified by morphological, chemotaxonomic and phylogenetic analyses to the genus Streptosporangium. The comparison of its physiological characteristics with those of known spe ...
DOI:: 10.1111/j.1365-2672.2006.03280.x
PubMed:: 17584469
: https://doi.org/10.1111/j.1365-2672.2006.03280.x

77. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy

Author:: Ebos, John M.L.; Lee, Christina R.; Christensen, James G.; Mutsaers, Anthony J.; Kerbel, Robert S.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.43 pp. 17069-17074
ISSN:: 0027-8424
Subject:: antineoplastic activity; biomarkers; blood proteins; dose response; drug resistance; drugs; genes; granulocyte colony-stimulating factor; hypoxia; malates; mice; osteopontin; patients; protein synthesis; receptor protein-tyrosine kinase; therapeutics; tissues; vascular endothelial growth factors
Abstract:: ... Cancer patients treated with antiangiogenic multitargeted receptor tyrosine kinase (RTK) inhibitors show increased levels of plasma VEGF and placental growth factor and decreased levels of soluble VEGF receptor-2, thus implicating these overall changes as a possible class effect of such drugs and raising the possibility of their exploitation as surrogate biomarkers for pharmacodynamic drug activit ...
DOI:: 10.1073/pnas.0708148104
PubMed:: 17942672
PubMed Central:: PMC2040401
: https://doi.org/10.1073/pnas.0708148104

78. Poecillastrin D: A New Cytotoxin of the Chondropsin Class from Marine Sponge Jaspis serpentina

Author:: Daisaku TAKEMOTO; Yoshihiko TAKEKAWA; Rob W. M. van SOEST; Nobuhiro FUSETANI; Shigeki MATSUNAGA
Source:: Bioscience, biotechnology, and biochemistry 2007 v.71 no.11 pp. 2697-2700
ISSN:: 1347-6947
Subject:: Astrophorida; antineoplastic activity; chemical structure; cytotoxicity; cytotoxins; lactams; macrolides; neoplasm cells
Abstract:: ... Poecillastrin D (2) was isolated together with poecillastrin C (1) from the deep sea sponge, Japsis serpentina. Its structure was elucidated to be that of a macrolide lactam by spectroscopic methods. These compounds showed potent cytotoxicity against various tumor cell lines. ...
DOI:: 10.1271/bbb.70293
: https://doi.org/10.1271/bbb.70293

79. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids

Author:: Chang, Ya-Jen; Huang, Jing-Rong; Tsai, Yi-Chien; Hung, Jung-Tung; Wu, Douglass; Fujio, Masakazu; Wong, Chi-Huey; Yu, Alice L.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.25 pp. 10299-10304
ISSN:: 0027-8424
Subject:: CD4-positive T-lymphocytes; antigen-presenting cells; antineoplastic activity; aromatic compounds; chemokines; clinical trials; glycolipids; humans; immunity; immunomodulators; lung neoplasms; mice; phosphorylation; sphingosine
Abstract:: ... α-Galactosylceramide (α-GalCer), a glycolipid that stimulates natural killer T (NKT) cells to produce both T helper (Th)1 and Th2 cytokines, has shown antitumor effects in mice but failed in clinical trials. We evaluated 16 analogs of α-GalCer for their CD1-mediated T cell receptor (TCR) activation of naïve human NKT cells and their anticancer efficacy. In vitro, glycolipids containing an aromatic ...
DOI:: 10.1073/pnas.0703824104
PubMed:: 17566107
PubMed Central:: PMC1965507
: https://doi.org/10.1073/pnas.0703824104

80. Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis

Author:: Jian Zhao; Koki Fujita; Kokki Sakai
Source:: new phytologist 2007 v.175 no.2 pp. 215-229
ISSN:: 0028-646X
Subject:: Cupressus lusitanica; antineoplastic activity; apoptosis; biosynthesis; calcium; cell culture; chelating agents; elicitors; hydrogen peroxide; nitric oxide; nitric oxide synthase; oxidants; oxygen; phytoalexins; proteinase inhibitors; superoxide anion; yeasts
Abstract:: ... • β‐Thujaplicin is a natural troponoid with strong antifungal, antiviral, and anticancer activities. β‐Thujaplicin production in yeast elicitor‐treated Cupressus lusitanica cell culture and its relationships with reactive oxygen species (ROS) and nitric oxide (NO) production and hypersensitive cell death were investigated. • Superoxide anion radical (O₂•–) induced cell death and inhibited β‐thujap ...
DOI:: 10.1111/j.1469-8137.2007.02109.x
PubMed:: 17587371
: https://doi.org/10.1111/j.1469-8137.2007.02109.x

81. Rutaceous alkaloids as models for the design of novel antitumor drugs

Author:: Tillequin, François
Source:: Phytochemistry reviews 2007 v.6 no.1 pp. 65-79
ISSN:: 1568-7767
Subject:: DNA adducts; Euodia; Zanthoxylum; alkaloids; anthranilic acid; antineoplastic activity; antineoplastic agents; biochemical pathways; clinical trials; esters; ethylene oxide; histidine; humans; mice; models; neoplasms; topology; tryptophan; tyrosine
Abstract:: ... The chemical diversity of alkaloids in the Rutaceae is correlated with biosynthetic pathways involving various aromatic amino acid precursors, tyrosine, tryptophan, histidine, and anthranilic acid. The interest of rutaceous polyheteroaromatic alkaloids as models for the development of anticancer agents relies on their frequent ability to interact with DNA or with systems involved in the control of ...
DOI:: 10.1007/s11101-006-9010-8
: https://doi.org/10.1007/s11101-006-9010-8

82. Seed germination and triterpenoid content of Anemopaegma arvense (Vell.) Stellfeld varieties

Author:: Pereira, Ana M. S.; Salomão, Antonieta N.; Januario, Ana H.; Bertoni, Bianca W.; Amui, Saulo F.; França, Suzelei C.; Cerdeira, Antonio L.; Moraes, Rita M.
Source:: Genetic resources and crop evolution 2007 v.54 no.4 pp. 849-854
ISSN:: 0925-9864
Subject:: Bignoniaceae; aerial parts; antineoplastic activity; betulinic acid; cerrado; dormancy; farmers; indigenous species; oleanolic acid; planting date; roots; savannas; seed germination; seedlings; seeds; storage temperature
Abstract:: ... Anemopaegma arvense (Vell.) Stellfeld, Bignoniaceae, is a native species of the Brazilian savanna (Cerrado) and is commonly known as catuaba among the local farmers. Seeds of three varieties were collected in different localities and submitted to germination and storage studies in attempting to domesticate this species as a medicinal crop for small farmers located in Brazilian Cerrado. Germination ...
DOI:: 10.1007/s10722-006-9161-x
: https://doi.org/10.1007/s10722-006-9161-x

83. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Author:: Siddiquee, Khandaker; Zhang, Shumin; Guida, Wayne C.; Blaskovich, Michelle A.; Greedy, Benjamin; Lawrence, Harshani R.; Yip, M.L. Richard; Jove, Richard; McLaughlin, Mark M.; Lawrence, Nicholas J.; Sebti, Said M.; Turkson, James
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.18 pp. 7391-7396
ISSN:: 0027-8424
Subject:: X-ray diffraction; antineoplastic activity; apoptosis; breast neoplasms; computer simulation; cyclins; genes; human growth; neoplasm cells; pro-apoptotic proteins; screening; transcription (genetics)
Abstract:: ... S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of the Stat3β homodimer. S3I-201 inhibits Stat3·Stat3 complex formation and Stat3 D ...
DOI:: 10.1073/pnas.0609757104
PubMed:: 17463090
PubMed Central:: PMC1863497
: https://doi.org/10.1073/pnas.0609757104

84. Selenomethionine induces polyamine biosynthesis in regenerating rat liver tissue

Author:: Bjelaković, G.; Beninati, S.; Pavlović, D.; Sokolović, D.; Stojanović, I.; Jevtović, T.; Bjelaković, G. B.; Nikolić, J.; Bašić, J.
Source:: Amino acids 2007 v.33 no.3 pp. 525-529
ISSN:: 0939-4451
Subject:: antineoplastic activity; biosynthesis; body weight; diamine oxidase; enzyme activity; liver; models; putrescine; rats; selenomethionine; spermidine; spermine
Abstract:: ... Our study was undertaken to elucidate the effects of selenomethionine (SeMet) on polyamine metabolism in regenerating rat liver tissue, as useful model of rapidly growing normal tissue. We have examined the levels of spermine, spermidine and putrescine in liver tissue. At the same time we have evaluated the activities of polyamine oxidase (PAO) and diamine oxidase (DAO), the catabolic enzymes of p ...
DOI:: 10.1007/s00726-006-0392-0
PubMed:: 17031481
: https://doi.org/10.1007/s00726-006-0392-0

85. Study of the changes of trans-resveratrol caused by ultraviolet light and determination of trans- and cis-resveratrol in Spanish white wines

Author:: López-Hernández, Julia; Paseiro-Losada, Perfecto; Sanches-Silva, Ana T.; Lage-Yusty, Maria Assunción
Source:: European food research & technology 2007 v.225 no.5-6 pp. 789-796
ISSN:: 1438-2377
Subject:: antineoplastic activity; exposure duration; food research; isomers; peanuts; pistachios; small fruits; ultraviolet radiation; wavelengths; white wines; Spain
Abstract:: ... Trans-resveratrol is a polyphenolic compound found in several foods items like wines, legumes, berries, peanuts and pistachios and lately it has attracted great attention due to its beneficial health effects such as anti-cancer, neuroprotective, anti-aging and anti-inflammatory. Therefore, it is important to identify all isomers and derivatives of this compound in order to avoid any errors in thei ...
DOI:: 10.1007/s00217-006-0483-x
: https://doi.org/10.1007/s00217-006-0483-x

86. TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts

Author:: Damiano, Vincenzo; Caputo, Rosa; Garofalo, Sonia; Bianco, Roberto; Rosa, Roberta; Merola, Gerardina; Gelardi, Teresa; Racioppi, Luigi; Fontanini, Gabriella; De Placido, Sabino; Kandimalla, Ekambar R.; Agrawal, Sudhir; Ciardiello, Fortunato; Tortora, Giampaolo
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.30 pp. 12468-12473
ISSN:: 0027-8424
Subject:: Toll-like receptor 9; adhesion; agonists; angiogenesis; antibodies; antineoplastic activity; colorectal neoplasms; cytotoxicity; drugs; endothelial cells; epidermal growth factor receptors; growth retardation; humans; immune response; mechanism of action; mice; neoplasm cells; oligonucleotides; patients; protein synthesis; secretion; vascular endothelial growth factors
Abstract:: ... Synthetic agonists of Toll-like receptor 9 (TLR9), a class of agents that induce specific immune response, exhibit antitumor activity and are currently being investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis are still incompletely understood. We recently discovered that a synthetic agonist of TLR9, immune modulatory oligonucleotide (IMO), ac ...
DOI:: 10.1073/pnas.0705226104
PubMed:: 17636117
PubMed Central:: PMC1920540
: https://doi.org/10.1073/pnas.0705226104

87. Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

Author:: Lu, Jun; Chew, Eng-Hui; Holmgren, Arne
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.30 pp. 12288-12293
ISSN:: 0027-8424
Subject:: DNA replication; NADP (coenzyme); antineoplastic activity; antineoplastic agents; apoptosis; arsenic; cell growth; cell proliferation; drug therapy; glutathione; glutathione-disulfide reductase; inhibitory concentration 50; leukemia; mammals; oxidation; oxidative stress; viability
Abstract:: ... Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic leukemia and has potential anticancer activity against a wide range of solid tumors. ATO exerts its effect mainly through elevated oxidative stress, but the exact molecular mechanism remains elusive. The thioredoxin (Trx) system comprising NADPH, thioredoxin reductase (TrxR), and Trx and the glutathione (GSH) sy ...
DOI:: 10.1073/pnas.0701549104
PubMed:: 17640917
PubMed Central:: PMC1940330
: https://doi.org/10.1073/pnas.0701549104

88. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

Author:: Gironella, Meritxell; Seux, Mylène; Xie, Min-Jue; Cano, Carla; Tomasini, Richard; Gommeaux, Julien; Garcia, Stephane; Nowak, Jonathan; Yeung, Man Lung; Jeang, Kuan-Teh; Chaix, Amandine; Fazli, Ladan; Motoo, Yoshiharu; Wang, Qing; Rocchi, Palma; Russo, Antonio; Gleave, Martin; Dagorn, Jean-Charles; Iovanna, Juan L.; Carrier, Alice; Pébusque, Marie-Josèphe; Dusetti, Nelson J.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.41 pp. 16170-16175
ISSN:: 0027-8424
Subject:: adenocarcinoma; antineoplastic activity; apoptosis; caspases; fibroblasts; gene overexpression; genes; immunohistochemistry; mice; microRNA; oncogene proteins; pancreatic neoplasms; prognosis
Abstract:: ... Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reex ...
DOI:: 10.1073/pnas.0703942104
PubMed:: 17911264
PubMed Central:: PMC2042180
: https://doi.org/10.1073/pnas.0703942104

89. The dihydro-β-agarofuran sesquiterpenoids

Author:: Jin-Ming Gao; Wen-Jun Wu; Ji-Wen Zhang; Yasuo Konishi
Source:: Natural product reports 2007 v.24 no.5 pp. 1153-1189
ISSN:: 1460-4752
Subject:: Celastraceae; Lamiaceae; antifeeding activity; antineoplastic activity; cytotoxicity; insecticidal properties; macrolides; multiple drug resistance; sesquiterpenoids
Abstract:: ... Dihydro-β-agarofuran sesquiterpenoids are a structurally diverse class of natural products based on tricyclic 5,11-epoxy-5β,10α-eudesman-4-(14)-ene skeleton. Between January 1990 and June 2006, 462 new dihydro-β-agarofuran sesquiterpenoids of 74 structural types have been isolated from about 64 species of Celastraceae, 3 species of Hippocrateaceae and one species of Lamiaceae. The present review c ...
DOI:: 10.1039/b601473a
: https://doi.org/10.1039/b601473a

90. The five bromotryptophans

Author:: Bittner, S.; Scherzer, R.; Harlev, E.
Source:: Amino acids 2007 v.33 no.1 pp. 19-42
ISSN:: 0939-4451
Subject:: Porifera; acids; antineoplastic activity; aquatic invertebrates; cathelicidins; cyclic peptides; ergot; humans; indole alkaloids; post-translational modification; secondary metabolites; spectral analysis; symbiosis; tryptophan
Abstract:: ... The five regioisomeric bromotryptophans (BrTrps) play an important role in the life of sponges and lower marine invertebrates. These bromo-amino acids, which are formed by post-translational modifications, are not found in nature in their free state, but rather are involved in more complex structures. Any of the BrTrps can be part of a peptide, a cyclic peptide, an indole alkaloid, an ergot alkalo ...
DOI:: 10.1007/s00726-006-0441-8
PubMed:: 17031473
: https://doi.org/10.1007/s00726-006-0441-8

91. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery

Author:: Lee, Jae K.; Havaleshko, Dmytro M.; Cho, HyungJun; Weinstein, John N.; Kaldjian, Eric P.; Karpovich, John; Grimshaw, Andrew; Theodorescu, Dan
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.32 pp. 13086-13091
ISSN:: 0027-8424
Subject:: algorithms; antineoplastic activity; breast neoplasms; chemical compounds; databases; drug therapy; drugs; human cell lines; humans; microarray technology; patients; prediction; screening; translation (genetics); urinary bladder neoplasms; United States
Abstract:: ... The U.S. National Cancer Institute has used a panel of 60 diverse human cancer cell lines (the NCI-60) to screen >100,000 chemical compounds for anticancer activity. However, not all important cancer types are included in the panel, nor are drug responses of the panel predictive of clinical efficacy in patients. We asked, therefore, whether it would be possible to extrapolate from that rich databa ...
DOI:: 10.1073/pnas.0610292104
PubMed:: 17666531
PubMed Central:: PMC1941805
: https://doi.org/10.1073/pnas.0610292104

92. 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

Author:: Wood, Edgar R.; Shewchuk, Lisa M.; Ellis, Byron; Brignola, Perry; Brashear, Ronald L.; Caferro, Thomas R.; Dickerson, Scott H.; Dickson, Hamilton D.; Donaldson, Kelly H.; Gaul, Michael; Griffin, Robert J.; Hassell, Anne M.; Keith, Barry; Mullin, Robert; Petrov, Kimberly G.; Reno, Michael J.; Rusnak, David W.; Tadepalli, Sarva M.; Ulrich, John C.; Wagner, Craig D.; Vanderwall, Dana E.; Waterson, Alex G.; Williams, Jon D.; White, Wendy L.; Uehling, David E.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.8 pp. 2773-2778
ISSN:: 0027-8424
Subject:: X-ray diffraction; acetylene; adenosine triphosphate; antineoplastic activity; carbon; cysteine; mass spectrometry; phosphotransferases (kinases); solvents; structure-activity relationships
Abstract:: ... Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent bond between the terminal carbon of the acetylene moiety and the sulfhydryl group of Cys-803 at the solvent interface. The identification of this covalent adduct suggested that acetylenic thienopyrimidine 6 and related analogs might also be capa ...
DOI:: 10.1073/pnas.0708281105
PubMed:: 18287036
PubMed Central:: PMC2268535
: https://doi.org/10.1073/pnas.0708281105

93. Antitumour and antimicrobial activities of endophytic streptomycetes from pharmaceutical plants in rainforest

Author:: Li, J.; Zhao, G.-Z.; Chen, H.-H.; Wang, H.-B.; Qin, S.; Zhu, W.-Y.; Xu, L.-H.; Jiang, C.-L.; Li, W.-J.
Source:: Letters in applied microbiology 2008 v.47 no.6 pp. 574-580
ISSN:: 0266-8254
Subject:: Candida albicans; Escherichia coli; Klebsiella pneumoniae; Staphylococcus aureus; Staphylococcus epidermidis; Streptomyces; agar; anti-infective properties; antineoplastic activity; cytotoxicity; endophytes; ligases; polyketide synthases; polymerase chain reaction; rain forests; China
Abstract:: ... The aim of this study was to screen antitumour and antimicrobial activities of endophytic actinomycetes isolated from pharmaceutical plants in rainforest in Yunnan province, China. Antitumour activity was studied by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and antimicrobial activity was determined by agar well diffusion method. The high bioactive endophytic isolates w ...
DOI:: 10.1111/j.1472-765X.2008.02470.x
PubMed:: 19120929
: https://doi.org/10.1111/j.1472-765X.2008.02470.x

94. Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

Author:: Kiyoyuki Yamada; Makoto Ojika; Hideo Kigoshi; Kiyotake Suenaga
Source:: Natural product reports 2008 v.26 no.1 pp. 27-43
ISSN:: 1460-4752
Subject:: Aplysia; X-radiation; antineoplastic activity; cytotoxicity; enantioselectivity; macrolides
Abstract:: ... Aplyronines A–H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of th ...
DOI:: 10.1039/b800263k
: https://doi.org/10.1039/b800263k

95. Application of partial least squares discriminant analysis and variable selection procedures: a 2D-PAGE proteomic study

Author:: Marengo, Emilio; Robotti, Elisa; Bobba, Marco; Milli, Alberto; Campostrini, Natascia; Righetti, Sabina Carla; Cecconi, Daniela; Righetti, Pier Giorgio
Source:: Analytical and bioanalytical chemistry 2008 v.390 no.5 pp. 1327-1342
ISSN:: 1618-2642
Subject:: antineoplastic activity; colorectal neoplasms; computer software; data collection; discriminant analysis; histone deacetylase; humans; image analysis; least squares; models; prediction; proteins; proteome; proteomics; tandem mass spectrometry; two-dimensional gel electrophoresis
Abstract:: ... 2D gel electrophoresis is a tool for measuring protein regulation, involving image analysis by dedicated software (PDQuest, Melanie, etc.). Here, partial least squares discriminant analysis was applied to improve the results obtained by classic image analysis and to identify the significant spots responsible for the differences between two datasets. A human colon cancer HCT116 cell line was analyz ...
DOI:: 10.1007/s00216-008-1837-y
PubMed:: 18224487
: https://doi.org/10.1007/s00216-008-1837-y

96. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics

Author:: Macfarlane, G.T.; Steed, H.; Macfarlane, S.
Source:: Journal of applied microbiology 2008 v.104 no.2 pp. 305-344
ISSN:: 1364-5072
Subject:: Bifidobacterium; Lactobacillus; Western diets; absorption; antineoplastic activity; cecum; colon; diarrhea; digestion; flatulence; fructooligosaccharides; galactooligosaccharides; intestinal microorganisms; inulin; lipid metabolism; prebiotics; probiotics; sensory properties
Abstract:: ... Most studies involving prebiotic oligosaccharides have been carried out using inulin and its fructo-oligosaccharide (FOS) derivatives, together with various forms of galacto-oligosaccharides (GOS). Although many intestinal bacteria are able to grow on these carbohydrates, most investigations have demonstrated that the growth of bifidobacteria, and to a lesser degree lactobacilli, is particularly f ...
DOI:: 10.1111/j.1365-2672.2007.03520.x
PubMed:: 18215222
: https://doi.org/10.1111/j.1365-2672.2007.03520.x

97. The Bisabolane Sesquiterpenoid Endoperoxide, 3,6-Epidioxy-1,10-bisaboladiene, Isolated from Cacalia delphiniifolia Inhibits the Growth of Human Cancer Cells and Induces Apoptosis

Author:: Koji NISHIKAWA; Nobuhiro ABURAI; Kyohei YAMADA; Hiroyuki KOSHINO; Eiko TSUCHIYA; Ken-ichi KIMURA
Source:: Bioscience, biotechnology, and biochemistry 2008 v.72 no.9 pp. 2463-2466
ISSN:: 1347-6947
Subject:: DNA fragmentation; antineoplastic activity; apoptosis; biotechnology; chromatin; cytotoxicity; humans; leukemia; moieties; prostatic neoplasms; sesquiterpenoids
Abstract:: ... In the course of our screening for a new anti-tumor substance, the bisabolane sesquiterpenoid endoperoxide, 3,6-epidioxy-1,10-bisaboladiene (EDBD), was isolated from the edible wild-plant, Cacalia delphiniifolia. EDBD showed cytotoxicity toward human chronic myelogenous leukemia K562 and human prostate carcinoma LNCaP cell lines with IC₅₀ values of 9.1 μM and 23.4 μM, respectively. DNA fragmentati ...
DOI:: 10.1271/bbb.80266
: https://doi.org/10.1271/bbb.80266

98. Bosellia serrata-induced apoptosis is related with ER stress and calcium release

Author:: Hyung-Ryong Kim; Myung-Sunny Kim; Dae-Young Kwon; Soo-Wan Chae; Han-Jung Chae
Source:: Genes & nutrition 2008 v.2 no.4 pp. 371-374
ISSN:: 1555-8932
Subject:: Boswellia serrata; anti-inflammatory activity; antineoplastic activity; antineoplastic agents; apoptosis; calcium; calpain; human cell lines; humans; neoplasm cells; proteins; staining; uterine cervical neoplasms
Abstract:: ... It has been reported that the gum resin of Boswellia serrata (BS), which has been shown to have antiinflammatory properties, might also have anticancer effects. This study examined the potential of BS as an anticancer agent. The BS extract induces apoptosis in HeLa human cervical carcinoma cells, as confirmed by two apoptosis analyses, Hoechst staining and Annexin V/PI assay. Among the apoptosis p ...
DOI:: 10.1007/s12263-007-0072-z
PubMed:: 18850233
PubMed Central:: PMC2478492
: https://doi.org/10.1007/s12263-007-0072-z

99. Cardio-Vascular and Metabolic Effects of Fish Oil

Author:: Gertjan Schaafsma
Source:: Nutrition and health 2008 v.19 no.3 pp. 229
ISSN:: 0260-1060
Subject:: European Union; antineoplastic activity; aquaculture; arrhythmia; blood lipids; colon; consumer behavior; essential fatty acids; fish; fish consumption; fish oils; food chain; food safety; glucose; heart; heart rate; insulin; lean body mass; lipid composition; minerals; nutrient density; nutrients; nutrition research; omega-3 fatty acids; overweight; patients; product development; seafoods; trace elements; traceability; vitamins; weight loss
Abstract:: ... Fish is a valuable source of a large variety of nutrients, including high-quality protein, essential fatty acids, vitamins, minerals and trace elements. Fish has an excellent nutrient density. A lot of attention nowadays is given to the nutritional significance of the fatty acids from fish, in particular, the omega-3 long-chain polyunsaturated fatty acids EPA and DHA. These fatty acids have been i ...
DOI:: 10.1177/026010600801900311
: https://doi.org/10.1177/026010600801900311

100. Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

Author:: Suresh R. Chawrai; Neil R. Williamson; George P. C. Salmond; Finian J. Leeper
Source:: Chemical communications 2008 v. no.16 pp. 1862-1864
ISSN:: 1364-548X
Subject:: Escherichia coli; Serratia; antineoplastic activity; chemical compounds; chemical reactions; immunosuppression; mutants; substrate specificity
Abstract:: ... Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, PigC, has a relaxed substrate-sp ...
DOI:: 10.1039/b719353j
: https://doi.org/10.1039/b719353j

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1. Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation

2. Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives

3. 6-(1-Alkenoyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives: Synthesis and evaluation of antitumor activity

4. Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains

5. Inhibition of Topoisomerases by Antitumor Prostaglandins.

6. Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice

7. Antitumor Activity of Phenylahistin in Vitro and in Vivo

8. Anticancer effects of selenium compounds on human colonic carcinoma cells

9. Solution Properties of Antitumor Sulfated Derivative of α-(1→3)-D-Glucan from Ganoderma lucidum

10. Antitumor Effect of Photodynamic Therapy with Zincphyrin, Zinc-coproporphyrin III, in Mice

11. Apoptosis-inducing Activity of a Driselase Digest Fraction of Green Tea Residue

12. In Vivo Antitumor Efficacy of CW252053, A Folate-based Thymidylate Synthase Inhibitor

13. Relationship between Solubility of Grifolan, a Fungal 1,3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro

14. Structure-activity relationship studies of isoquinolinone type anticancer agent

15. Antiangiogenic activity ofBupleurum longiradiatum on human umbilical venous endothelial cells

16. Augmentation of macrophage antitumor activities and nitric oxide production by oregonin

17. Chemical modification of alisol B 23-acetate and their cytotoxic activity

18. Design and synthesis of isoindoloquinoline derivatives as potential antitumor agents

19. Enhancement of nk cytotoxicity, antimetastasis and elongation effect of survival time in b16-f10 melanoma cells by oregonin

20. Immunomodulatory activity of protein-bound polysaccharide extracted from chelidonium majus

21. In Vitro pharmacodynamics of CKD-602 in HT-29 cells

22. Inhibitory Properties of Antitumor Prostaglandins against Topoisomerases

23. Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice

24. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

25. Sulfated glycofuranans as inhibitors of melanoma lung metastasis

26. Synthesis of polyamides containingN-methylpyrrole andN-meth-ylimidazole and their anticancer activity

27. Synthesis, cytotoxicity and antitumor activity of 2,3-Diarylcy-clopent-2-ene-1-ones

28. Anti-tumor Activity of Daphne mucronata Extract and its Effects on TNF-a Receptors and TNF-a Release in Cultured Human Monocytes

29. Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

30. Bioactivity from Toona ciliata stem bark

31. Carbohydrates—The Renewable Raw Materials of High Biotechnological Value

32. Cytotoxic and antitumor activities of ethanolic extracts of salt marsh plants from the lower saxonian wadden sea, southern north sea

33. Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs

34. Screening for antitumor activity of 11 species of Indonesian Zingiberaceae using human MCF-7 and HT-29 cancer cells

35. Structural Revision of Sulfated Polysaccharide B-1 Isolated from a Marine Pseudomonas Species and Its Cytotoxic Activity Against Human Cancer Cell Lines

36. Anti-Tumor Activity of an Enzymatically Synthesized α-1,6 Branched α-1,4-Glucan, Glycogen

37. Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus

38. Hot off the press

39. Differential cytotoxic effects ofAnnona squamosa seed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione

40. Effect of Molecular Mass on Antitumor Activity of Heteropolysaccharide from Poria cocos

41. Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae

42. Immunostimulatory Effects of a Polysaccharide-Rich Substance with Antitumor Activity Isolated from Black Currant (Ribes nigrum L.)

43. Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

44. Using genomics to deliver natural products from symbiotic bacteria

45. Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice

46. Biological activity of vanadium compounds

47. Genes of multidrug resistance in haematological malignancies

48. Induction of a Ribotoxic Stress Response That Stimulates Stress-Activated Protein Kinases by 13-Deoxytedanolide, an Antitumor Marine Macrolide

49. Isolation of methyl gallate and evaluation of the antibacterial and antineoplastic activity of some extracts ofKlainedoxa gabonensis Pierre ex Engl.

50. The Morita–Baylis–Hillman adducts of β-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

51. A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen

52. Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy

53. Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors

54. Two fucoidans in the holdfast of cultivated Laminaria japonica

55. Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis

56. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

57. Antitumor and Cytotoxic Effects of Phyllanthus polyphyllus on Ehrlich Ascites Carcinoma and Human Cancer Cell Lines

58. Antiviral activity of oxidized polyamines

59. Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth

60. Biologically active, synthetic ion transporters

61. Cloning, expression, and antitumor activity of recombinant protein of curcin

62. Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

63. Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

64. Endogenous IL-12 triggers an antiangiogenic program in melanoma cells

65. Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential

66. Evaluation of Nutritional Availability and Anti-Tumor Activity of Selenium Contained in Selenium-Enriched Kaiware Radish Sprouts

67. First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol

68. Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt

69. Hydroxymethylfurfural: an enemy or a friendly xenobiotic? A bioanalytical approach

70. Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis