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1. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

Author:
Haibo Zhang; Jun-Koo Yi; Hai Huang; Sijun Park; Wookbong Kwon; Eungyung Kim; Soyoung Jang; Si-Yong Kim; Seong-kyoon Choi; Duhak Yoon; Sung-Hyun Kim; Kangdong Liu; Zigang Dong; Zae Young Ryoo; Myoung Ok Kim
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 396-407
ISSN:
1226-8453
Subject:
Panax; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; colorectal neoplasms; morbidity; mortality; neoplasm cells; research; toxicity; transfection; xenotransplantation
Abstract:
... Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, and western ...
DOI:
10.1016/j.jgr.2021.07.004

2. 3D printed tablets containing oxaliplatin loaded alginate nanoparticles for colon cancer targeted delivery. An in vitro/in vivo study

Author:
Seyedeh Zahra Mirdamadian; Jaleh Varshosaz; Mohsen Minaiyan; Azade Taheri
Source:
International journal of biological macromolecules 2022 v.205 pp. 90-109
ISSN:
0141-8130
Subject:
alginates; antineoplastic activity; cancer therapy; colorectal neoplasms; drugs; extrusion; intestines; intravenous injection; oral administration; printers; stomach; three-dimensional printing
Abstract:
... This study aimed to develop a colon-targeted tablet of oxaliplatin (OP) using the combination of nanotechnology and fused deposition modeling (FDM) 3D printing to improve its antitumor activity, tumor targetability, and safety profile. Eudragit L100-55 filament containing OP loaded alginate nanoparticles (OP-NPs) were fabricated using hot-melt extrusion method and printed by an FDM printer to 3D p ...
DOI:
10.1016/j.ijbiomac.2022.02.080

3. A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

Author:
Nawal Abd El-Baky; Esmail M. EL-Fakharany; Soraya A. Sabry; Ehab R. El-Helow; Elrashdy Mustafa Redwan; Amira Sabry
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
Escherichia coli; antineoplastic activity; cell free system; cell-free protein synthesis; genes; humans; neoplasm cells; recombinant proteins; response surface methodology; temperature; tumor necrosis factor-alpha
Abstract:
... Cell-free (in vitro) expression is a robust alternative platform to the cell-based (in vivo) system for recombinant protein production. Tumor necrosis factor-alpha (TNF-α) is an effective pro-inflammatory cytokine with pleiotropic effects. The aim of the current study was de novo optimized expression of soluble and active human TNF-α by an in vitro method in an E. coli-based cell-free protein synt ...
DOI:
10.3390/biology11020157

4. A bone implant with NIR-responsiveness for eliminating osteosarcoma cells and promoting osteogenic differentiation of BMSCs

Author:
Zhuangzhuang Wu; Qiaoqiao Tian; Jiani Wang; Yi Feng; Lizhi Li; Chaojian Xu; Jia Lv; Zhi Lv
Source:
Colloids and surfaces 2022 v.211 pp. 112296
ISSN:
0927-7765
Subject:
alloys; antineoplastic activity; bone formation; collagen; fever; fluorine; irradiation; osteosarcoma; photocatalysis; prostheses; reactive oxygen species; synergism; therapeutics; titanium dioxide
Abstract:
... Incomplete removal of tumor cells and insufficient osseointegration are the main causes of bone tumor recurrence and implantation failure. In the present study, a multifunctional titanium-based bioactive implant for near-infrared-triggered synergy therapy to overcome these hurdles is engineered, composed of titanium dioxide (TiO₂) nanoparticles doped with fluorine (F)/dopamine (PDA)/collagen. The ...
DOI:
10.1016/j.colsurfb.2021.112296

5. A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis

Author:
Ting Ge; Zhang Weiwei; Fei Ge; Longbao Zhu; Ping Song; Wanzheng Li; Lin Gui; Wan Dong; Yugui Tao; Kai Yang
Source:
Biomaterials science 2022 v.10 no.7 pp. 1831-1843
ISSN:
2047-4849
Subject:
antineoplastic activity; apoptosis; biocompatible materials; cell cycle; coordination polymers; cytotoxicity; dimensional stability; drug carriers; drug resistance; drug therapy; fluorouracil; human cell lines; metastasis; mice; near infrared radiation; neoplasms; photothermotherapy; polyethylene glycol; thermal stability
Abstract:
... Chemotherapy is a conventional treatment method for metastatic bone cancer, but it has limitations, such as lower drug-targeting of bone tissues and serious side effects. Bone metastasis almost always occurs in advanced cancer, and most patients in this period have strong drug resistance, which further worsens the curative effect. To address the above-mentioned difficulties, a drug delivery platfo ...
DOI:
10.1039/d1bm01717a

6. A chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation

Author:
Xiang-xiang Jin; Ya-nan Mei; Zhe Shen; Ju-fan Zhu; Sun-hui Xing; Hua-mao Yang; Guang Liang; Xiao-hui Zheng
Source:
Phytomedicine 2022 v.101 pp. 154087
ISSN:
0944-7113
Subject:
DNA damage; DNA replication; adhesion; antineoplastic activity; apoptosis; breast neoplasms; cell adhesion; cell cycle checkpoints; cell proliferation; chalcone; cytotoxicity; drugs; flow cytometry; fluorescence microscopy; hybrids; neoplasm cells; non-specific protein-tyrosine kinase; phosphorylation; relapse; sequence analysis; signal transduction; transactivators; transcriptome
Abstract:
... Although triple-negative breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have a ...
DOI:
10.1016/j.phymed.2022.154087

7. A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Author:
Şeyda Berk; Savaş Kaya; Esra Küpeli Akkol; Hilal Bardakçı
Source:
Phytomedicine 2022 v.98 pp. 153938
ISSN:
0944-7113
Subject:
Lewis acids; antimicrobial properties; antineoplastic activity; antioxidant activity; density functional theory; epidemiology; flavonoids; glycemic effect; hardness; lung neoplasms; lungs
Abstract:
... It is well-known that flavonoids, which can be easily obtained from many fruits and vegetables are widely preferred in the treatment of some important diseases. Some researchers noted that these chemical compounds exhibit high inhibition effect against various cancer types. Many experimental studies proving this ability of the flavonoids with high antioxidant activity are available in the literatu ...
DOI:
10.1016/j.phymed.2022.153938

8. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

Author:
Fazhi Su; Yanping Sun; Wenbo Zhu; Chenxi Bai; Wensen Zhang; Yumeng Luo; Bingyou Yang; Haixue Kuang; Qiuhong Wang
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114798
ISSN:
0378-8741
Subject:
Arisaema; analgesics; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cough; epilepsy; flavonoids; germplasm; pharmacodynamics; pharmacokinetics; quality control; rheumatoid arthritis; sedatives; snake bites; tetanus; therapeutics; toxicity; toxicology; traditional medicine
Abstract:
... The genus Arisaema belongs to the family Araceae, which includes Chinese herbal medicines with wide-ranging pharmacological functions, including those useful for the treatment of stubborn phlegm, cough, epilepsy, tetanus, snakebite, rheumatoid arthritis, and other ailments.The current study aimed to comprehensively review the botany, uses, phytochemistry, pharmacology, toxicity, quality control an ...
DOI:
10.1016/j.jep.2021.114798

9. A comprehensive review on angel's trumpet (Brugmansia suaveolens)

Author:
Swati Pundir; Monu Kumar Shukla; Amardeep Singh; Raveen Chauhan; Uma Ranjan Lal; Aalia Ali; Deepak Kumar
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Brugmansia suaveolens; antineoplastic activity; antiseptics; arthritis; atropine; dermatitis; fungi; glycosides; ingredients; leaves; pain; phytochemicals; terpenoids; toxicity; Africa; Asia; Australia; Europe
Abstract:
... Angel's trumpet or Brugmanisa suaveolens (B. suaveolens), belonging to the family Solanaceae, distributed in Africa, America, Europe, Australia and Asia, has been used traditionally for the treatment of arthritis, sores, pain, inflammation, ulcers, abscesses, dermatitis, wounds, dysmenorrhea, fungal infections of the skin and as vaginal antiseptic in white secretions. Phytochemical studies of B. s ...
DOI:
10.1016/j.sajb.2022.02.023

10. A multimodal Metal-Organic framework based on unsaturated metal site for enhancing antitumor cytotoxicity through Chemo-Photodynamic therapy

Author:
Qiongjie Ding; Zhijue Xu; Luyi Zhou; Congying Rao; Weimin Li; Mohd. Muddassir; Hiroshi Sakiyama; Bo Li; Qin Ouyang; Jianqiang Liu
Source:
Journal of colloid and interface science 2022 v.621 pp. 180-194
ISSN:
0021-9797
Subject:
aminolevulinic acid; antineoplastic activity; chemical bonding; coordination polymers; cytotoxicity; fluorescein; folic acid; photochemotherapy; porosity
Abstract:
... Chemodynamic therapy when combined with chemotherapy opens up a new avenue for treatment of cancer. However, its development is still restricted by low targeting, high dose and toxic side effects. Herein, rational designing and construction of a new multifunctional platform with the core–shell structure 5-ALA@UiO-66-NH-FAM@CP1 (ALA = 5-aminolevulinic acid, CP1 = zirconium-pemetrexed (Zr-MTA)) has ...
DOI:
10.1016/j.jcis.2022.04.078

11. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

Author:
Victor Pallarès; Ugutz Unzueta; Aïda Falgàs; Anna Aviñó; Yáiza Núñez; Annabel García-León; Laura Sánchez-García; Naroa Serna; Alberto Gallardo; Lorena Alba-Castellón; Patricia Álamo; Jorge Sierra; Lídia Cedó; Ramon Eritja; Antonio Villaverde; Esther Vázquez; Isolda Casanova; Ramon Mangues
Source:
Biomaterials 2022 v.280 pp. 121258
ISSN:
0142-9612
Subject:
CXCR4 receptor; antineoplastic activity; biocompatible materials; bone marrow; drug therapy; liver; mice; myeloid leukemia; nanomedicine; spleen; toxicity
Abstract:
... Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled, multivalent protein nanoparticle, targeting the CXCR4 receptor, with an Oligo-Ara-C prodrug, a pentameric form of A ...
DOI:
10.1016/j.biomaterials.2021.121258

12. A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Author:
Xiaojing Zhang; Zhenzhen Liu; Shuaipeng Chen; Hang Li; Lin Dong; Xueyan Fu
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114742
ISSN:
0378-8741
Subject:
Bupleurum chinense; RNA; Western blotting; active ingredients; adhesion; antineoplastic activity; apoptosis; cell structures; colon; colorectal neoplasms; databases; dose response; flow cytometry; fluorescent antibody technique; gene expression; homeopathic drugs; humans; phosphatidylinositol 3-kinase; pro-apoptotic proteins; saponins; survival rate; traditional medicine; China
Abstract:
... Bupleurum chinense DC has a history of using herb in China for more than 2000 years, which can be traced back to the Classic of Shennong Materia Medica in the Han Dynasty. Although Saikosaponin, the main active ingredient of Bupleurum, has the effects of anti-tumor, yet we still do not know the mechanism by total Bupleurum saponin extracts (TBSE) produces this effect on colon cancer.It is predicte ...
DOI:
10.1016/j.jep.2021.114742

13. A novel multifunctional nanoparticles formed by molecular recognition between AS1411 aptamer and redox-responsive paclitaxel-nucleoside analogue prodrug for combination treatment of β-lapachone and paclitaxel

Author:
Xuling Chen; Jianbo Ji; Ke Zhou; Xiaohui Fan; Lingbing Li; Wei Xu
Source:
Colloids and surfaces 2022 v.212 pp. 112345
ISSN:
0927-7765
Subject:
antineoplastic activity; blood circulation; cell membranes; drug therapy; drugs; growth retardation; hydrogen bonding; neoplasm cells; neoplasms; nucleosides; oligonucleotides; paclitaxel; quinones; reactive oxygen species; solubility; thymine
Abstract:
... Despite its high antitumor activity, the clinical application of chemotherapy is greatly impeded by lacking of specific accumulation and poor solubility. To address the above challenges, we designed a AS1411 aptamer modified nanoparticles based on molecular recognition of nucleobases. Firstly, a redox sensitive Paclitaxel-SS-Zidovudine (PZ) prodrug was synthesized. Then PZ/β-lapachone/AS1411/DSPE- ...
DOI:
10.1016/j.colsurfb.2022.112345

14. A self-amplified ROS-responsive chemodrug–inhibitor conjugate for multi-drug resistance tumor therapy

Author:
Tingting Sun; Jie Xu; Tianbao Chen; Chunlai Tu; Lijuan Zhu; Deyue Yan
Source:
Biomaterials science 2022 v.10 no.4 pp. 997-1007
ISSN:
2047-4849
Subject:
P-glycoproteins; adenosine triphosphate; alpha-tocopherol; antineoplastic activity; biocompatible materials; cancer therapy; drug therapy; endocytosis; models; multiple drug resistance; neoplasms; polyethylene; reactive oxygen species; succinic acid; tamoxifen
Abstract:
... P-glycoprotein (P-gp) induced multidrug resistance (MDR) is the main reason for the failure of cancer chemotherapy. The combined delivery of chemodrug and P-gp inhibitor is a promising pathway to reverse MDR. However, the intrinsic stimuli in the tumor microenvironment could not realize a complete drug release, which would induce poor cancer therapeutic efficacy. Herein, we conjugated tamoxifen (T ...
DOI:
10.1039/d1bm01605a

15. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

Author:
Guoliang Dai; Dong Wang; Shitang Ma; Shengwei Hong; Kang Ding; Xiying Tan; Wenzheng Ju
Source:
Phytomedicine 2022 v.102 pp. 154149
ISSN:
0944-7113
Subject:
Rheum palmatum; Western blotting; antineoplastic activity; carcinogenesis; cell proliferation; colorectal neoplasms; data collection; databases; emodin; gene expression regulation; immunohistochemistry; ingredients; mice; mortality; secretion; therapeutics; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2
Abstract:
... Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown. The present study is aimed to explore the potential anti-tumor effects of emodin against CRC ...
DOI:
10.1016/j.phymed.2022.154149

16. Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Author:
Chunyu Jiang; Mengyue Yang; Chunxue Zhao; Fangshen Liu; Hangao Yang; Zhanlin Li; Tong Han; Bin Lin; Dahong Li; Huiming Hua
Source:
Phytochemistry 2022 v.199 pp. 113187
ISSN:
0031-9422
Subject:
Cephalotaxus; antineoplastic activity; apoptosis; circular dichroism spectroscopy; cytotoxicity; diterpenoids; humans; neoplasm cells; plant biochemistry; spectral analysis
Abstract:
... Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglypti ...
DOI:
10.1016/j.phytochem.2022.113187

17. Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

Author:
Yemeng Tang; Yanmao Wang; Xian Wang; Zhucheng Zhao; Haijian Cai; Mengyao Xie; Xintong Jiang; Luyao Zhang; Jiayun Cheng; Lehe Yang; Liangxing Wang; Chengguang Zhao; Xiaoying Huang
Source:
Phytomedicine 2022 v.101 pp. 154109
ISSN:
0944-7113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell movement; drug resistance; epidermal growth factor receptors; flow cytometry; fluorescent antibody technique; humans; lung neoplasms; mechanism of action; models; morbidity; phosphorylation; proteome; signal transduction; survival rate; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is one of the most common types of malignant tumor. It has one of the highest morbidity and mortality rates worldwide, and approximately 85% of cases are non-small cell lung cancer (NSCLC). Clinically, several EGFR inhibitors have been used to treat NSCLC, but resistance can develop. Studies have shown that cross talk between signal transducer and activator of transcription 3 (STAT3) a ...
DOI:
10.1016/j.phymed.2022.154109

18. Acid-sensitive charge-reversal co-assembled polyurethane nanomicelles as drug delivery carriers

Author:
Jingyi Liu; Zhoutong Dai; Yu Zhou; Wangwang Tao; Hongxiang Chen; Zuyi Zhao; Xinghua Liao
Source:
Colloids and surfaces 2022 v.209 pp. 112203
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; blood; cytotoxicity; drugs; electrostatic interactions; gel chromatography; micelles; neoplasms; nuclear magnetic resonance spectroscopy; pH; polyurethanes
Abstract:
... In order to obtain drug delivery carriers with good stability in blood and high cellular uptake efficiency, carboxyl groups and tertiary amine groups were respectively introduced into polyurethane to synthesize two kinds of amphiphilic polyurethanes with opposite charges (PUC and PUN). Their structures were characterized by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance ...
DOI:
10.1016/j.colsurfb.2021.112203

19. Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation

Author:
Haroon Khan; Fabiana Labanca; Hammad Ullah; Yaseen Hussain; Nikolay T. Tzvetkov; Esra Küpeli Akkol; Luigi Milella
Source:
Phytochemistry reviews 2022 v.21 no.2 pp. 385-400
ISSN:
1568-7767
Subject:
DNA; antineoplastic activity; apoptosis; breasts; cancer therapy; cell cycle checkpoints; cell proliferation; dietary supplements; drug therapy; excision; gene expression; germ cells; immunotherapy; mortality; neoplasm progression; phytochemicals; polyphenols; radiotherapy; risk
Abstract:
... Over the years, the attention towards the role of phytochemicals in dietary natural products in reducing the risk of developing cancer is rising. Cancer is the second primary cause of mortality worldwide. The current therapeutic options for cancer treatment are surgical excision, immunotherapy, chemotherapy, and radiotherapy. Unfortunately, in case of metastases or chemoresistance, the treatment o ...
DOI:
10.1007/s11101-021-09771-3

20. Ag nanoparticles enhance immune checkpoint blockade efficacy by promoting of immune surveillance in melanoma

Author:
Xinwei Kuang; Zhenxing Wang; Zhongwei Luo; Zehui He; Long Liang; Qian Gao; Youyou Li; Kun Xia; Zuozhong Xie; Ruimin Chang; Yiyi Wang; Yiwei Liu; Shuang Zhao; Juan Su; Yang Wang; Weiyi Situ; Mingliang Chen; Yuetao Zhao; Xiang Chen; Hui Xie; Hong Liu
Source:
Journal of colloid and interface science 2022 v.616 pp. 189-200
ISSN:
0021-9797
Subject:
antineoplastic activity; apoptosis; cell proliferation; cytotoxicity; immunotherapy; immunotoxicity; ligands; melanoma; monitoring; nanosilver; neoplasm cells; sucrose
Abstract:
... Immune checkpoint blockade (ICB) therapy, represented by programmed cell death protein 1 (PD-1) and its ligand (PD-L1) monoclonal antibodies (mAbs), has shown an obvious benefit for melanoma immunotherapy, but the overall response rate is still low. To find an effective combination therapy strategy, we successfully produced small size silver nanoparticles coated with sucrose (S-AgNPs) as potent ad ...
DOI:
10.1016/j.jcis.2022.02.050

21. Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells

Author:
Ying Liu; Xiaobei Liu; Hui Wang; Pingping Ding; Changlin Wang
Source:
Phytomedicine 2022 v.101 pp. 154102
ISSN:
0944-7113
Subject:
Agrimonia pilosa; antineoplastic activity; apoptosis; computer software; databases; energy; ferroptosis; flow cytometry; immunoblotting; iron; models; mortality; neoplasm cells; neoplasm progression; ovarian neoplasms; reactive oxygen species; toxicity testing; toxicogenomics; xenotransplantation
Abstract:
... Ovarian cancer is a gynaecological tumour has high incidence and mortality rates. Agrimonolide, isolated from Agrimonia pilosa Ledeb, has multiple biomedical activities, including anticancer activity. Here, we aimed to reveal the function of agrimonolide on ovarian cancer progression. MTT assay, colony-formation assay, flow cytometry, transwell assay, scratch test, western immunoblotting, reactive ...
DOI:
10.1016/j.phymed.2022.154102

22. Alhagi honey polysaccharides encapsulated into PLGA nanoparticle-based pickering emulsion as a novel adjuvant to induce strong and long-lasting immune responses

Author:
Adelijiang Wusiman; Jin He; Gaofeng Cai; Tianyu Zhu; Ruonan Bo; Zhenguang Liu; Yuanlaing Hu; Deyun Wang
Source:
International journal of biological macromolecules 2022 v.202 pp. 130-140
ISSN:
0141-8130
Subject:
Alhagi maurorum; adsorption; antineoplastic activity; cytokines; emulsions; honey; humoral immunity; lymph; perennials; polysaccharides; vaccine adjuvants
Abstract:
... Alhagi honey polysaccharides, extracted from a perennial plant Alhagi pseudalhagi syn, possessed many biological activities such as immune enhancement, anti-tumor effect, and antioxygenation. In this study, we used Alhagi honey polysaccharide encapsulated (poly lactic-co-glycolic acid) (PLGA) nanoparticles to prepare an assembled particles-oil pickering emulsion: PPAS and PEI-PPAS. We investigated ...
DOI:
10.1016/j.ijbiomac.2022.01.020

23. Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis

Author:
Linlin Wang; Li Cheng; Li Ma; Ammad Ahmad Farooqi; Gan Qiao; Yuxi Zhang; Hanlin Ye; Minghua Liu; Jianlin Huang; Xiaohui Yang; Xiukun Lin; Shousong Cao
Source:
Phytotherapy research 2022 v.36 no.1 pp. 525-542
ISSN:
0951-418X
Subject:
acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; growth retardation; hepatoma; humans; liver; membrane potential; mitochondrial membrane; phytotherapy; research; xenotransplantation
Abstract:
... Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results showed that alnu ...
DOI:
10.1002/ptr.7337

24. Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways

Author:
Hyeon Jeong Kim; Ji Won Choi; Jin Ree; Jung Sik Lim; Jisun Lee; Jun Il Kim; Samir Bahadur Thapa; Jae Kyung Sohng; Yong Il Park
Source:
Life sciences 2022 v.300 pp. 120495
ISSN:
0024-3205
Subject:
Aloe; DNA fragmentation; Western blotting; antineoplastic activity; apoptosis; caspase-9; cell growth; cell movement; cytotoxicity; emodin; glycosylation; histopathology; humans; intraperitoneal injection; lung neoplasms; membrane potential; mitochondrial membrane; mortality; neoplasm cells; water solubility; xenotransplantation
Abstract:
... Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer with a high mortality rate. Glycosylation of phenolic compounds may increase water-solubility and pharmacological activities and reduce the toxicity of aglycones. This study aimed to evaluate and compare the anticancer effect of aloe emodin 3-O-glucoside (AE3G) and its aglycone, aloe emodin (AE), against NSCLC. A human ade ...
DOI:
10.1016/j.lfs.2022.120495

25. Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy

Author:
Miaomiao Han; Yan Li; Shun Lu; Biao Yuan; Shujie Cheng; Chongjiang Cao
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13743-13757
ISSN:
1944-8252
Subject:
adhesion; adsorption; amyloid; antineoplastic activity; bioavailability; biomimetics; camouflage; catechin; cell proliferation; disulfides; hydrophobicity; inflammation; irradiation; isoelectric point; neoplasm cells; neoplasms; phosphine; photothermotherapy; protein corona
Abstract:
... Polydopamine (PDA) shows great application potential in photothermal therapy (PTT) of tumors due to its excellent photothermal performance. However, PDA rich in a large number of catechin structures, with strong adhesion, can readily attach to plasma proteins in blood to form protein corona, which greatly hinders the transfer efficiency to tumors and reduces the bioavailability. In this paper, a s ...
DOI:
10.1021/acsami.2c00716

26. An all-in-one adjuvanted therapeutic cancer vaccine targeting dendritic cell cytosol induces long-lived tumor suppression through NLRC4 inflammasome activation

Author:
Sao Puth; Vivek Verma; Seol Hee Hong; Wenzhi Tan; Shee Eun Lee; Joon Haeng Rhee
Source:
Biomaterials 2022 pp. 121542
ISSN:
0142-9612
Subject:
T-lymphocytes; adjuvants; antineoplastic activity; bacteriophages; biocompatible materials; cancer vaccines; cytosol; cytotoxicity; dendritic cells; epitopes; flagellin; immunization; inflammasomes; neoplasm antigens; neoplasms; peptides
Abstract:
... Therapeutic cancer vaccines (TCVs) should induce robust tumor-specific T cell responses. To achieve this, TCVs incorporate T cell epitopes and strong adjuvants. Here, we report an all-in-one adjuvanted cancer vaccine platform that targets the intracellular compartment of antigen-presenting cells and subsequently induces effective cytotoxic T cell responses. We screened a novel peptide (DCpep6) tha ...
DOI:
10.1016/j.biomaterials.2022.121542

27. An ester derivative of tenacigenin B from Marsdenia tenacissima (Roxb.) Wight et Arn reversed paclitaxel-induced MDR in vitro and in vivo by inhibiting both P-gp and MRP2

Author:
Zhou-Li Wu; Yan Chen; Zhao Qu; Gui-Yun Wu; Xiao-Feng He; Jia-Wen Huang; Qi-Qi Meng; Yuan-Hao Hu; Xiao-Ling Shen; Rui-Yi Yang; Ying-Jie Hu
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115353
ISSN:
0378-8741
Subject:
Marsdenia tenacissima; P-glycoproteins; antineoplastic activity; cancer therapy; chronic exposure; human cell lines; humans; immunohistochemistry; medicinal plants; mice; multiple drug resistance; neoplasm cells; paclitaxel; permeability; raw materials; toxicity; traditional medicine; uterine cervical neoplasms; vinblastine; xenotransplantation
Abstract:
... Marsdenia tenacissima is a medicinal plant, used as a raw material for cancer treatment in China. In our previous studies, 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B (MT2), the main steroid aglycone isolated from M. tenacissima, was found to significantly enhance the antitumor activity of paclitaxel (PTX) in vivo. However, it is unclear whether MT2 reverses multidrug resistance (MDR) in tu ...
DOI:
10.1016/j.jep.2022.115353

28. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

Author:
Junqian Zhang; Chunjie Li; Li Zhang; Yongqing Heng; Shiwen Wang; Yongfu Pan; Lili Cai; Yunjing Zhang; Tong Xu; Xihui Chen; Robert M Hoffman; Lijun Jia
Source:
Phytomedicine 2022 v.98 pp. 153933
ISSN:
0944-7113
Subject:
Andrographis; DNA damage; Oriental traditional medicine; adenocarcinoma; andrographolide; anti-inflammatory agents; antineoplastic activity; cancer therapy; cell cycle checkpoints; cell proliferation; cell senescence; flow cytometry; humans; lung neoplasms; lungs; mice; neoplasm cells; protein content; xenotransplantation
Abstract:
... Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) is a diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the potential to target senescence in recalcitrant lung cancer. To determine whether AD can induce senescence in ...
DOI:
10.1016/j.phymed.2022.153933

29. Anti-Colon Cancer Activity of Novel Peptides Isolated from In Vitro Digestion of Quinoa Protein in Caco-2 Cells

Author:
Xin Fan; Huimin Guo; Cong Teng; Biao Zhang; Christophe Blecker; Guixing Ren
Source:
Foods 2022 v.11 no.2 pp. -
ISSN:
2304-8158
Subject:
Western blotting; antineoplastic activity; carcinogenesis; colorectal neoplasms; digestion; histone deacetylase; interleukin-6; interleukin-8; liquid chromatography; protein hydrolysates; quantitative polymerase chain reaction; tandem mass spectrometry
Abstract:
... Quinoa peptides are the bioactive components obtained from quinoa protein digestion, which have been proved to possess various biological activities. However, there are few studies on the anticancer activity of quinoa peptides, and the mechanism has not been clarified. In this study, the novel quinoa peptides were obtained from quinoa protein hydrolysate and identified by liquid chromatography–tan ...
DOI:
10.3390/foods11020194

30. Anti-Gastric Cancer Effect of Purified Omphalia lapidescens Protein via Regulating the JAK/STAT3 Signaling Pathway

Author:
Yuqin Xu; Wenjun Xu; Zhongxia Lu; Man Hei Cheung; Meiai Lin; Chun Liang; Jianshu Lou; Yitao Chen
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1780-1791
ISSN:
1532-7914
Subject:
agonists; antineoplastic activity; bioinformatics; cell proliferation; death; flow cytometry; gene expression regulation; glycoproteins; interleukin-6; microarray technology; neoplasm cells; non-specific protein-tyrosine kinase; nutrition; stomach neoplasms; transactivators; viability; xenotransplantation
Abstract:
... Gastric cancer is the leading cause of cancer-related death worldwide. The aim of present study was to investigate the anti-tumor effect of purified Omphalia lapidescens protein (pPeOp) in gastric cancer. Microarray analysis was performed to find out differentially expressed genes in pPeOp-treated MC-4 gastric cancer cells. The Janus kinase (JAK)/signal transducer and activator of transcription (S ...
DOI:
10.1080/01635581.2021.1960385

31. Anti-cancer, anti-bacterial and anti-oxidant properties of an active fraction isolated from Curcuma zedoaria rhizomes

Author:
Sharaf Shehna; S Sreelekshmi; PR Remani; G Padmaja; S Lakshmi
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100195
ISSN:
2667-0313
Subject:
Curcuma zedoaria; Oriental traditional medicine; antimicrobial properties; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell cycle checkpoints; cyclophosphamide; longevity; lung neoplasms; lymphoma; phytochemicals; solvents; therapeutics; toxicity
Abstract:
... Curcuma zedoaria is a plant with rich source of phytochemicals extensively used in ayurvedic and Chinese medicine to treat tumors and other ailments. Henceforth, this study was undertaken to scientifically validate the different solvent fractions and isolate active fraction from the plant for the study pertaining to different biological activities including cancer. The objectives of the study incl ...
DOI:
10.1016/j.phyplu.2021.100195

32. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

Author:
Zhijun Li; Haiying Bao
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114898
ISSN:
0378-8741
Subject:
Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
Abstract:
... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
DOI:
10.1016/j.jep.2021.114898

33. Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma

Author:
Yang Shen; Fan Yang; Haiyan Peng; Guangji Zhang; Fangfang Zhu; Haojun Xu; Le Shi
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114601
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; blood serum; cell growth; flow cytometry; hepatoma; mice; models; protein synthesis; xenotransplantation
Abstract:
... Yanggan Huayu granule (YGHY) is a formula of traditional Chinese medicine that has been widely used to treat patients with liver cancer. But its working mechanism is still poorly understood.Aim of the study: To investigate the anti-tumor effect of YGHY and its working mechanisms in hepatocellular carcinoma (HCC).H22 mouse xenograft model was used to detect the effect of YGHY on hepatocellular carc ...
DOI:
10.1016/j.jep.2021.114601

34. Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts

Author:
Kartik Chandra Guchhait; Tuhin Manna; Manas Barai; Monalisha Karmakar; Sourav Kumar Nandi; Debarati Jana; Aditi Dey; Suman Panda; Priyanka Raul; Anuttam Patra; Rittwika Bhattacharya; Subhrangsu Chatterjee; Amiya Kumar Panda; Chandradipa Ghosh
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 42
ISSN:
2662-7671
Subject:
Azadirachta indica; Staphylococcus aureus; Vibrio cholerae; acridine orange; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; bacterial culture; biofilm; breast neoplasms; cell lines; cytotoxicity; ethidium; fluorescence microscopy; gas chromatography; humans; mass spectrometry; methanol; minimum inhibitory concentration; multiple drug resistance; neoplasm cells; phthalic acid; toxicity testing; triazines
Abstract:
... BACKGROUND: Antibiotic resistances of pathogens and breast cancer warrant the search for new alternative strategies. Phytoextracts can eradicate microbe-borne diseases as well as cancer with lower side effects compared to conventional antibiotics. AIM: Unripe and ripe Azadirachta indica (neem) seed extracts were explored as potential antibiofilm and anticancer agents in combating multidrug-resista ...
DOI:
10.1186/s12906-022-03513-4

35. Anticancer Activity of Leonurus sibiricus L.: Possible Involvement of Intrinsic Apoptotic Pathway

Author:
Vasanth Krishnan; Selvakumar Subramaniam; Chang Chia–Chuan; Balamurugan Venkatachalam; Amal Thomas Cheeran; Huang Chi-Ying F.
Source:
Nutrition and cancer 2022 v.74 no.1 pp. 225-236
ISSN:
1532-7914
Subject:
Leonurus sibiricus; antineoplastic activity; apoptosis; beta-carotene; caspase-3; caspase-8; caspase-9; dose response; gene expression; humans; liver neoplasms; lutein; mitochondria; mortality; nutrition; toxicity testing
Abstract:
... Liver cancer is the most common cause of mortality in men and women. The aim of this study was to evaluate the methanolic extract of aerial parts of Leonurus sibiricus L (LS) for its anticancer activity on HCC cell lines. Human HCC cell lines, Huh-7 and HSC-T6 were used for cytotoxicity assay, determination of ROS and gene expression analysis (p53, Bcl-2, Bax, caspase-3, caspase-8, and caspase-9). ...
DOI:
10.1080/01635581.2020.1870702

36. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis

Author:
Thoria Donia; Marian N Gerges; Tarek M Mohamed
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1802-1818
ISSN:
1532-7914
Subject:
Brassicaceae; antineoplastic activity; antineoplastic agents; apoptosis; ascites; autophagy; blood serum; body weight; carcinoma; caspase-3; females; gene expression; histopathology; mice; models; nutrition
Abstract:
... Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. Eighty female mice were divided into six groups wherein all groups except groups I and II received EAC cells (10⁶ cells/mouse i.p.). Gro ...
DOI:
10.1080/01635581.2021.1960388

37. Anticancer activity of Alpinia purpurata (Vieill) K. Schum. against MNU and testosterone induced prostate cancer in male Wistar albino rats

Author:
Anusooriya Palanirajan; Poornima Kannappan; Gopalakrishnan Velliyur Kanniappan
Source:
Pharmacological research 2022 pp. 100105
ISSN:
2667-1425
Subject:
Alpinia purpurata; Oriental traditional medicine; albino; anesthesia; antineoplastic activity; antineoplastic agents; antioxidants; blood serum; carcinoma; caudal vein; cervical dislocation; chloroform; ethyl acetate; herbal medicines; histopathology; ingredients; intraperitoneal injection; intravenous injection; kidneys; leaf extracts; leaves; lipids; liver; males; nucleic acids; propylene glycol; prostate gland; prostatic neoplasms; protein content; research; seminal vesicles; testosterone; toxicity
Abstract:
... : Numerous Chinese herbal extracts have been proved to inhibit the development of prostate cancer. Zingiberaceae family is one type of plant used as an ingredient in traditional Chinese medicine (TCM). The genus Alpinia species of the Zingiberaceae family are well-known traditional herbal medicine for anti-inflammatory, antioxidant, antimicrobial, anti-dermatophytic, anti-nociceptive, hepatoprotec ...
DOI:
10.1016/j.prmcm.2022.100105

38. Anticancer activity of N-heteroaryl acetic acid salts against breast cancer; in silico and in vitro investigation

Author:
Samaneh Zolghadri; Ali Ghanbariasad; Fatemeh Fallahian; Mahdie Rahban; Mahsa Kalavani; Enayatollah Bahman Jahromi; Azizeh Asadzadeh; Maliheh Hajiani
Source:
Molecular biology reports 2022 v.49 no.1 pp. 363-372
ISSN:
0301-4851
Subject:
acetic acid; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; cancer therapy; caspase-3; caspase-8; computer simulation; cytotoxicity; flow cytometry; gene expression; genes; histone deacetylase; inhibitory concentration 50; mechanism of action; molecular biology; neoplasm cells; quantitative polymerase chain reaction
Abstract:
... BACKGROUND: The present research was performed to assess N-heteroaryl acetic acid salts' anticancer activity against the breast cancer cell in order to introduce new inhibitory agents for histone deacetylase. METHODS AND RESULTS: A molecular docking simulation was performed to design the rational novel compounds. Afterward, the best compounds were selected for synthesis. The cytotoxic effects and ...
DOI:
10.1007/s11033-021-06881-1

39. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

Author:
Shilpa Kuttikrishnan; Ajaz A. Bhat; Jericha M. Mateo; Fareed Ahmad; Feras Q. Alali; Tamam El-Elimat; Nicholas H. Oberlies; Cedric J. Pearce; Shahab Uddin
Source:
Biochemical and biophysical research communications 2022 v.601 pp. 59-64
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; caspases; cell viability; fungi; leukemia; meroterpenoids; mitochondria; oncogenes; pro-apoptotic proteins; research; secondary metabolites; therapeutics
Abstract:
... Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes A ...
DOI:
10.1016/j.bbrc.2022.02.071

40. Anticancer activity of Neptunia oleracea methanolic extracts

Author:
Archana Bhumireddy; Kavitha Nellore; Krishna Satya Alapati
Source:
Natural product research 2022 v.36 no.4 pp. 1053-1057
ISSN:
1478-6427
Subject:
Neptunia oleracea; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; dysentery; ethnobotany; medicinal plants; neoplasm cells; neoplasms; phytochemicals; research
Abstract:
... Neptunia oleracea Lour (water mimosa) is an edible medicinal plant used in treating various diseases. According to Phytochemical and Ethnobotanical Databases, Neptunia oleracea Lour is used in curing earaches, dysentery, syphilis, and tumour. The present study was aimed at demonstrating the anticancer activity of the Neptunia oleracea Lour methanolic extract. The methanolic extract was isolated an ...
DOI:
10.1080/14786419.2020.1844693

41. Anticancer effect of marine bivalves derived polysaccharides against human cancer cells

Author:
Deepakrajasekar Padmanaban; Angeline Samuel; Gracy Jenifer Sahayanathan; Kavitha Raja; Arulvasu Chinnasamy
Source:
Biocatalysis and agricultural biotechnology 2022 v.39 pp. 102240
ISSN:
1878-8181
Subject:
Bivalvia; DNA fragmentation; acridine orange; agricultural biotechnology; antineoplastic activity; antineoplastic agents; apoptosis; biocatalysis; breasts; clinical examination; colon; cytotoxicity; enzymatic hydrolysis; ethidium; humans; inhibitory concentration 50; liver; marine environment; polypeptides; polysaccharides; propidium; rhodamines; therapeutics
Abstract:
... In recent decades, studies on cancer prophylactics and therapeutics with development of novel anticancer drugs have garnered interest on a global scale. The diverse marine environment is a major source of biocompounds and has been acknowledged as an important platform for drug discovery. A wide variety of novel agents in the form of protein, polysaccharide, polypeptide and steroid from marine micr ...
DOI:
10.1016/j.bcab.2021.102240

42. Anticancer effects of picrasidine I on oral squamous cell carcinoma

Author:
Yuan‐Ting Yang; Ming‐Ju Hsieh; Yi‐Ching Chuang; Chia‐Chieh Lin; Yu‐Sheng Lo; Hsin‐Yu Ho; V. Bharath Kumar; Jiunn‐Liang Ko
Source:
Environmental toxicology 2022 v.37 no.3 pp. 627-636
ISSN:
1520-4081
Subject:
Picrasma quassioides; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; caspases; cell viability; cyclins; cytotoxicity; death; dose response; ecotoxicology; membrane potential; mitochondrial membrane; mouth neoplasms; phosphorylation; squamous cell carcinoma; therapeutics
Abstract:
... Picrasidine I is a dimeric alkaloid derived from a Southern Asian plant Picrasma quassioides and demonstrated to possess pharmacological activities, such as anti‐inflammatory and anti‐osteoclastogenic effects. However, its potential anticancer effect remains unclear. In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with differen ...
DOI:
10.1002/tox.23430

43. Anticancer effects of veratramine via the phosphatidylinositol-3-kinase/serine-threonine kinase/mechanistic target of rapamycin and its downstream signaling pathways in human glioblastoma cell lines

Author:
Daehwan Kim; Wookbong Kwon; Song Park; Wansoo Kim; Jin-Kyu Park; Jee Eun Han; Gil-Jae Cho; Sungho Yun; Se-Hyeon Han; Myoung Ok Kim; Zae Young Ryoo; Seong-Kyoon Choi
Source:
Life sciences 2022 v.288 pp. 120170
ISSN:
0024-3205
Subject:
antineoplastic activity; apoptosis; cell proliferation; cytotoxicity; dose response; flow cytometry; glioblastoma; humans; liver; rapamycin; therapeutics
Abstract:
... Antitumor effects of veratramine in prostate and liver cancers has been investigated, but it is still unclear whether veratramine can be used as an effective therapeutic agent for glioma. The aim of this study was to evaluate the potential pharmacological mechanism of veratramine in glioma.Using four types of human glioblastoma cell lines, including A172, HS-683, T98G, and U-373-MG the dose-depend ...
DOI:
10.1016/j.lfs.2021.120170

44. Anticancer property of Selaginella bryopteris (L.) Bak. against hepatocellular carcinoma in vitro and in vivo

Author:
Lal Chand Pal; Arti Gautam; Veena Pande; Ch V Rao
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100201
ISSN:
2667-0313
Subject:
Selaginella bryopteris; acute toxicity; animal models; antineoplastic activity; antioxidant activity; apoptosis; carbon tetrachloride; caspase-3; caspase-9; catalase; cell viability; chemical constituents of plants; diethylnitrosamine; drugs; gallic acid; gas chromatography-mass spectrometry; gene expression; genes; hepatoma; histology; human cell lines; humans; imidazole; liver; liver function; lupeol; membrane potential; mitochondrial membrane; mortality; myo-inositol; neoplasm cells; palmitic acid; reactive oxygen species; reverse transcriptase polymerase chain reaction; silymarin; therapeutics; toxicity testing
Abstract:
... Hepatocellular carcinoma (HCC) is the most common and leading cause of cancer-related mortality worldwide. It has limited therapeutic options and side effects caused by current treatment methods. Selaginella bryopteris is used traditionally in the treatment of several health-related problems but mostly remains to be scientific validation. This study investigated the effect of Selaginella bryopteri ...
DOI:
10.1016/j.phyplu.2021.100201

45. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:
Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:
2662-7671
Subject:
Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:
... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:
10.1186/s12906-022-03526-z

46. Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic

Author:
Ebrahim Mostafavi; Atefeh Zarepour; Hamed Barabadi; Ali Zarrabi; Linh B. Truong; David Medina-Cruz
Source:
Biotechnology reports 2022 v.34 pp. e00714
ISSN:
2215-017X
Subject:
antineoplastic activity; bioavailability; biosynthesis; biotechnology; drugs; gold; humans; leukemia; nanogold; silver; society; therapeutics; toxicity
Abstract:
... The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different strategies that have been explored, nanotechnology appears to be a promising and effective approach fo ...
DOI:
10.1016/j.btre.2022.e00714

47. Antitumor Effect of Manool in a Murine Melanoma Model

Author:
Heloiza Diniz Nicolella; Arthur Barcelos Ribeiro; Matheus Reis Santos de Melo; Saulo Duarte Ozelin; Lucas Henrique Domingos da Silva; Rodrigo Cássio Sola Veneziani; Denise Crispim Tavares
Source:
Journal of natural products 2022 v.85 no.2 pp. 426-432
ISSN:
1520-6025
Subject:
Salvia officinalis; antineoplastic activity; caspase-3; cisplatin; cytotoxicity; diterpenoids; melanoma; mice; mitosis; models
Abstract:
... The manool diterpene, found in abundance in Salvia officinalis L., showed a selective cytotoxic effect against murine melanoma cells. Therefore, the present study aimed to evaluate the antitumor potential of manool in a murine melanoma model, administered by three routes: oral, subcutaneous, and intraperitoneal. In addition, the antimelanoma effect of manool (orally) combined with cisplatin (subcu ...
DOI:
10.1021/acs.jnatprod.1c01128

48. Antitumor and antimicrobial activity of fatty acids from green microalga Coelastrella sp. BGV

Author:
Tanya Toshkova-Yotova; Ani Georgieva; Ivan Iliev; Svetoslav Alexandrov; Albena Ivanova; Plamen Pilarski; Reneta Toshkova
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Candida albicans; Klebsiella pneumoniae; Pseudomonas aeruginosa; antifungal properties; antineoplastic activity; apoptosis; botany; fatty acid composition; fluorescence microscopy; fungi; gas chromatography-mass spectrometry; humans; linoleic acid; microalgae; neoplasms; oleic acid; palmitic acid; pathogens; polyunsaturated fatty acids; therapeutics; Bulgaria
Abstract:
... Green microalgae are a valuable source of biologically active substances with antitumor and antimicrobial effects. Coelastrella sp. BGV is a strain of green microalga isolated in Bulgaria. The aim of the study was to analyze the fatty acid profile of Coelastrella sp. BGV and to assess the antitumor and antimicrobial activities of the extracted free fatty acids. The fatty acid content of a total li ...
DOI:
10.1016/j.sajb.2022.04.003

49. Antitumor and hepatoprotective effect of Cuscuta reflexa Roxb. in a murine model of colon cancer

Author:
Shobhit Mishra; Fahad Saad Alhodieb; Md. Abul Barkat; Mohd. Zaheen Hassan; Harshita Abul Barkat; Raisuddin Ali; Perwaiz Alam; Ozair Alam
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114597
ISSN:
0378-8741
Subject:
Cuscuta reflexa; X-radiation; acute oral toxicity; analgesics; animal models; anthelmintics; antineoplastic activity; apoptosis; barium; cell proliferation; colon; colonoscopy; colorectal neoplasms; erythrocytes; fluorouracil; hemoglobin; hepatoprotective effect; histology; histopathology; hydrazine; mitosis; neoplasm progression; neutrophils; traditional medicine
Abstract:
... Cuscuta reflexa Roxb. (C. reflexa) is a well-known traditional herbal plant, with numerous inherent therapeutic potentials including anticancer, antitumor, antibacterial, analgesic, anthelmintic, laxative and others. Moreover, the anticancer and antitumor potentials of this herb are ongoing with several trails, thus an attempt was made to assess the anticancer and hepatoprotective potentials of tr ...
DOI:
10.1016/j.jep.2021.114597

50. Antitumor bioactivity and gut microbiota modulation of polyhydroxybutyrate (PHB) in a rat animal model for colorectal cancer

Author:
Javier Fernández; Paolo Saettone; Mauro Comes Franchini; Claudio J. Villar; Felipe Lombó
Source:
International journal of biological macromolecules 2022 v.203 pp. 638-649
ISSN:
0141-8130
Subject:
3-hydroxybutyric acid; animal models; antineoplastic activity; appetite; bioactive compounds; brain; butyrates; cognition; colorectal neoplasms; diabetes; digestive system; fossils; intestinal microorganisms; polyhydroxybutyrate; prebiotics; rats
Abstract:
... Polyhydroxybutyrate (PHB) is a non-toxic polyhydroxyalkanoate polymer produced by several microorganisms, widely used as a biological substitute for plastics derived from fossil hydrocarbons. In this work, PHB polymer has been tested in an animal model for colorectal cancer. In the animal model, PHB has been able to reduce the number of polyps by 48,1%, and the tumoral extension area by 58,1%. Als ...
DOI:
10.1016/j.ijbiomac.2022.01.112