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1. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

Author:
Haibo Zhang; Jun-Koo Yi; Hai Huang; Sijun Park; Wookbong Kwon; Eungyung Kim; Soyoung Jang; Si-Yong Kim; Seong-kyoon Choi; Duhak Yoon; Sung-Hyun Kim; Kangdong Liu; Zigang Dong; Zae Young Ryoo; Myoung Ok Kim
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 396-407
ISSN:
1226-8453
Subject:
Panax; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; colorectal neoplasms; morbidity; mortality; neoplasm cells; research; toxicity; transfection; xenotransplantation
Abstract:
... Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, and western ...
DOI:
10.1016/j.jgr.2021.07.004

2. A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

Author:
Nawal Abd El-Baky; Esmail M. EL-Fakharany; Soraya A. Sabry; Ehab R. El-Helow; Elrashdy Mustafa Redwan; Amira Sabry
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
Escherichia coli; antineoplastic activity; cell free system; cell-free protein synthesis; genes; humans; neoplasm cells; recombinant proteins; response surface methodology; temperature; tumor necrosis factor-alpha
Abstract:
... Cell-free (in vitro) expression is a robust alternative platform to the cell-based (in vivo) system for recombinant protein production. Tumor necrosis factor-alpha (TNF-α) is an effective pro-inflammatory cytokine with pleiotropic effects. The aim of the current study was de novo optimized expression of soluble and active human TNF-α by an in vitro method in an E. coli-based cell-free protein synt ...
DOI:
10.3390/biology11020157

3. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

Author:
Fazhi Su; Yanping Sun; Wenbo Zhu; Chenxi Bai; Wensen Zhang; Yumeng Luo; Bingyou Yang; Haixue Kuang; Qiuhong Wang
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114798
ISSN:
0378-8741
Subject:
Arisaema; analgesics; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cough; epilepsy; flavonoids; germplasm; pharmacodynamics; pharmacokinetics; quality control; rheumatoid arthritis; sedatives; snake bites; tetanus; therapeutics; toxicity; toxicology; traditional medicine
Abstract:
... The genus Arisaema belongs to the family Araceae, which includes Chinese herbal medicines with wide-ranging pharmacological functions, including those useful for the treatment of stubborn phlegm, cough, epilepsy, tetanus, snakebite, rheumatoid arthritis, and other ailments.The current study aimed to comprehensively review the botany, uses, phytochemistry, pharmacology, toxicity, quality control an ...
DOI:
10.1016/j.jep.2021.114798

4. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

Author:
Victor Pallarès; Ugutz Unzueta; Aïda Falgàs; Anna Aviñó; Yáiza Núñez; Annabel García-León; Laura Sánchez-García; Naroa Serna; Alberto Gallardo; Lorena Alba-Castellón; Patricia Álamo; Jorge Sierra; Lídia Cedó; Ramon Eritja; Antonio Villaverde; Esther Vázquez; Isolda Casanova; Ramon Mangues
Source:
Biomaterials 2022 v.280 pp. 121258
ISSN:
0142-9612
Subject:
CXCR4 receptor; antineoplastic activity; biocompatible materials; bone marrow; drug therapy; liver; mice; myeloid leukemia; nanomedicine; spleen; toxicity
Abstract:
... Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled, multivalent protein nanoparticle, targeting the CXCR4 receptor, with an Oligo-Ara-C prodrug, a pentameric form of A ...
DOI:
10.1016/j.biomaterials.2021.121258

5. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

Author:
Guoliang Dai; Dong Wang; Shitang Ma; Shengwei Hong; Kang Ding; Xiying Tan; Wenzheng Ju
Source:
Phytomedicine 2022 v.102 pp. 154149
ISSN:
0944-7113
Subject:
Rheum palmatum; Western blotting; antineoplastic activity; carcinogenesis; cell proliferation; colorectal neoplasms; data collection; databases; emodin; gene expression regulation; immunohistochemistry; ingredients; mice; mortality; secretion; therapeutics; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2
Abstract:
... Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown. The present study is aimed to explore the potential anti-tumor effects of emodin against CRC ...
DOI:
10.1016/j.phymed.2022.154149

6. Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

Author:
Yemeng Tang; Yanmao Wang; Xian Wang; Zhucheng Zhao; Haijian Cai; Mengyao Xie; Xintong Jiang; Luyao Zhang; Jiayun Cheng; Lehe Yang; Liangxing Wang; Chengguang Zhao; Xiaoying Huang
Source:
Phytomedicine 2022 v.101 pp. 154109
ISSN:
0944-7113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell movement; drug resistance; epidermal growth factor receptors; flow cytometry; fluorescent antibody technique; humans; lung neoplasms; mechanism of action; models; morbidity; phosphorylation; proteome; signal transduction; survival rate; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is one of the most common types of malignant tumor. It has one of the highest morbidity and mortality rates worldwide, and approximately 85% of cases are non-small cell lung cancer (NSCLC). Clinically, several EGFR inhibitors have been used to treat NSCLC, but resistance can develop. Studies have shown that cross talk between signal transducer and activator of transcription 3 (STAT3) a ...
DOI:
10.1016/j.phymed.2022.154109

7. Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells

Author:
Ying Liu; Xiaobei Liu; Hui Wang; Pingping Ding; Changlin Wang
Source:
Phytomedicine 2022 v.101 pp. 154102
ISSN:
0944-7113
Subject:
Agrimonia pilosa; antineoplastic activity; apoptosis; computer software; databases; energy; ferroptosis; flow cytometry; immunoblotting; iron; models; mortality; neoplasm cells; neoplasm progression; ovarian neoplasms; reactive oxygen species; toxicity testing; toxicogenomics; xenotransplantation
Abstract:
... Ovarian cancer is a gynaecological tumour has high incidence and mortality rates. Agrimonolide, isolated from Agrimonia pilosa Ledeb, has multiple biomedical activities, including anticancer activity. Here, we aimed to reveal the function of agrimonolide on ovarian cancer progression. MTT assay, colony-formation assay, flow cytometry, transwell assay, scratch test, western immunoblotting, reactive ...
DOI:
10.1016/j.phymed.2022.154102

8. Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis

Author:
Linlin Wang; Li Cheng; Li Ma; Ammad Ahmad Farooqi; Gan Qiao; Yuxi Zhang; Hanlin Ye; Minghua Liu; Jianlin Huang; Xiaohui Yang; Xiukun Lin; Shousong Cao
Source:
Phytotherapy research 2022 v.36 no.1 pp. 525-542
ISSN:
0951-418X
Subject:
acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; growth retardation; hepatoma; humans; liver; membrane potential; mitochondrial membrane; phytotherapy; research; xenotransplantation
Abstract:
... Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results showed that alnu ...
DOI:
10.1002/ptr.7337

9. Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy

Author:
Miaomiao Han; Yan Li; Shun Lu; Biao Yuan; Shujie Cheng; Chongjiang Cao
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13743-13757
ISSN:
1944-8252
Subject:
adhesion; adsorption; amyloid; antineoplastic activity; bioavailability; biomimetics; camouflage; catechin; cell proliferation; disulfides; hydrophobicity; inflammation; irradiation; isoelectric point; neoplasm cells; neoplasms; phosphine; photothermotherapy; protein corona
Abstract:
... Polydopamine (PDA) shows great application potential in photothermal therapy (PTT) of tumors due to its excellent photothermal performance. However, PDA rich in a large number of catechin structures, with strong adhesion, can readily attach to plasma proteins in blood to form protein corona, which greatly hinders the transfer efficiency to tumors and reduces the bioavailability. In this paper, a s ...
DOI:
10.1021/acsami.2c00716

10. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

Author:
Junqian Zhang; Chunjie Li; Li Zhang; Yongqing Heng; Shiwen Wang; Yongfu Pan; Lili Cai; Yunjing Zhang; Tong Xu; Xihui Chen; Robert M Hoffman; Lijun Jia
Source:
Phytomedicine 2022 v.98 pp. 153933
ISSN:
0944-7113
Subject:
Andrographis; DNA damage; Oriental traditional medicine; adenocarcinoma; andrographolide; anti-inflammatory agents; antineoplastic activity; cancer therapy; cell cycle checkpoints; cell proliferation; cell senescence; flow cytometry; humans; lung neoplasms; lungs; mice; neoplasm cells; protein content; xenotransplantation
Abstract:
... Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) is a diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the potential to target senescence in recalcitrant lung cancer. To determine whether AD can induce senescence in ...
DOI:
10.1016/j.phymed.2022.153933

11. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

Author:
Zhijun Li; Haiying Bao
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114898
ISSN:
0378-8741
Subject:
Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
Abstract:
... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
DOI:
10.1016/j.jep.2021.114898

12. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis

Author:
Thoria Donia; Marian N Gerges; Tarek M Mohamed
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1802-1818
ISSN:
1532-7914
Subject:
Brassicaceae; antineoplastic activity; antineoplastic agents; apoptosis; ascites; autophagy; blood serum; body weight; carcinoma; caspase-3; females; gene expression; histopathology; mice; models; nutrition
Abstract:
... Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. Eighty female mice were divided into six groups wherein all groups except groups I and II received EAC cells (10⁶ cells/mouse i.p.). Gro ...
DOI:
10.1080/01635581.2021.1960388

13. Anticancer effects of picrasidine I on oral squamous cell carcinoma

Author:
Yuan‐Ting Yang; Ming‐Ju Hsieh; Yi‐Ching Chuang; Chia‐Chieh Lin; Yu‐Sheng Lo; Hsin‐Yu Ho; V. Bharath Kumar; Jiunn‐Liang Ko
Source:
Environmental toxicology 2022 v.37 no.3 pp. 627-636
ISSN:
1520-4081
Subject:
Picrasma quassioides; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; caspases; cell viability; cyclins; cytotoxicity; death; dose response; ecotoxicology; membrane potential; mitochondrial membrane; mouth neoplasms; phosphorylation; squamous cell carcinoma; therapeutics
Abstract:
... Picrasidine I is a dimeric alkaloid derived from a Southern Asian plant Picrasma quassioides and demonstrated to possess pharmacological activities, such as anti‐inflammatory and anti‐osteoclastogenic effects. However, its potential anticancer effect remains unclear. In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with differen ...
DOI:
10.1002/tox.23430

14. Antitumor and hepatoprotective effect of Cuscuta reflexa Roxb. in a murine model of colon cancer

Author:
Shobhit Mishra; Fahad Saad Alhodieb; Md. Abul Barkat; Mohd. Zaheen Hassan; Harshita Abul Barkat; Raisuddin Ali; Perwaiz Alam; Ozair Alam
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114597
ISSN:
0378-8741
Subject:
Cuscuta reflexa; X-radiation; acute oral toxicity; analgesics; animal models; anthelmintics; antineoplastic activity; apoptosis; barium; cell proliferation; colon; colonoscopy; colorectal neoplasms; erythrocytes; fluorouracil; hemoglobin; hepatoprotective effect; histology; histopathology; hydrazine; mitosis; neoplasm progression; neutrophils; traditional medicine
Abstract:
... Cuscuta reflexa Roxb. (C. reflexa) is a well-known traditional herbal plant, with numerous inherent therapeutic potentials including anticancer, antitumor, antibacterial, analgesic, anthelmintic, laxative and others. Moreover, the anticancer and antitumor potentials of this herb are ongoing with several trails, thus an attempt was made to assess the anticancer and hepatoprotective potentials of tr ...
DOI:
10.1016/j.jep.2021.114597

15. Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-ζ to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression

Author:
Hung-Jen Lin; Ramasamy Mahendran; Hsiang-Yen Huang; Ping-Ling Chiu; Yung-Ming Chang; Cecilia Hsuan Day; Ray-Jade Chen; V. Vijaya Padma; Yang Liang-Yo; Wei-Wen Kuo; Chih-Yang Huang
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114728
ISSN:
0378-8741
Subject:
Solanum nigrum; actin; angiotensin II; antineoplastic activity; cardiac output; cardioprotective effect; diarrhea; dose response; eyes; fever; fluorescent antibody technique; glycoproteins; heart; heart failure; hypertrophy; liver; males; psoriasis; ringworm; steroid alkaloids; steroid saponins; traditional medicine
Abstract:
... Solanum nigrum, commonly known as Makoi or black shade has been traditionally used in Asian countries and other regions of world to treat liver disorders, diarrhoea, inflammatory conditions, chronic skin ailments (psoriasis and ringworm), fever, hydrophobia, painful periods, eye diseases, etc. It has been observed that S. nigrum contains substances, like steroidal saponins, total alkaloid, steroid ...
DOI:
10.1016/j.jep.2021.114728

16. Aqueous two-phase extraction of polysaccharides from Selaginella doederleinii and their bioactivity study

Author:
Gang Li; Xiankui Ma; Yongmei Jiang; Weiwei Li; Yongling Wang; Li Liu; Chengxin Sun; Shiji Xiao; Jie Lan; Juxiang Kuang; Gang Wang
Source:
Process biochemistry 2022 v.118 pp. 274-282
ISSN:
1359-5113
Subject:
Selaginella doederleinii; antineoplastic activity; antioxidant activity; antioxidants; ethanol; liquids; polysaccharides; salt concentration; thermogravimetry; ultrasonics
Abstract:
... In this study, the ethanol/salt aqueous two-phase system was firstly used to extract Selaginella doederleinii polysaccharides (SDP). Through single factor and response surface analysis, the best extraction conditions were as follows: extraction time of 40 min, ultrasonic power of 280 W, ethanol concentration of 35%, inorganic salt concentration of 0.22 g/mL, and liquid/solid ratio of 25 mL/g with ...
DOI:
10.1016/j.procbio.2022.04.024

17. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

18. Assessment of the anti-tumor activity of cyanidin-3-O-arabinoside from apple against APN, JAK, and EZH2 target proteins

Author:
Dan Zhang; Zhipeng Yu; Wenzhu Zhao; Jingbo Liu
Source:
Food bioscience 2022 pp. 101788
ISSN:
2212-4292
Subject:
antineoplastic activity; apoptosis; apples; colon; colorectal neoplasms; humans; interphase; membrane alanyl aminopeptidase; non-specific protein-tyrosine kinase; polyphenols
Abstract:
... This study aimed to evaluate the anti-tumor activity and the mechanism of apple polyphenols on aminopeptidase N (APN), janus kinase 3 (JAK3) and enhancer of zeste homolog 2 (EZH2) using molecular docking and in vitro human colon (Caco-2) cells. The 88 apple polyphenols were docked with targets, i.e., APN, JAK3, and EZH2, and the potential polyphenol cyanidin-3-O-arabinoside was selected. CCK-8 ass ...
DOI:
10.1016/j.fbio.2022.101788

19. Ataxia-telangiectasia mutated & ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer.

Author:
Chloe Gulliver; Ralf Hoffmann; George S Baillie
Source:
international journal of biochemistry & cell biology 2022 pp. 106230
ISSN:
1357-2725
Subject:
DNA; DNA damage; antineoplastic activity; biomarkers; cell death; drug development; drug resistance; drug therapy; genomics; medicine; metastasis; mutants; phenotype; phosphotransferases (kinases); prognosis; prostatic neoplasms; relapse
Abstract:
... The DNA damage response is an integral part of a cells’ ability to maintain genomic integrity by responding to and ameliorating DNA damage, or initiating cell death for irrepairably damaged cells. This response is often hijacked by cancer cells to evade cell death allowing mutant cells to persist, as well as in the development of treatment resistance to DNA damaging agents such as chemotherapy and ...
DOI:
10.1016/j.biocel.2022.106230

20. BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology

Author:
S. Hao; V.V. Inamdar; E.C. Sigmund; F. Zhang; S.B. Stephan; C. Watson; S.J. Weaver; U.B. Nielsen; M.T. Stephan
Source:
Journal of controlled release 2022 v.342 pp. 14-25
ISSN:
0168-3659
Subject:
T-lymphocytes; antineoplastic activity; drugs; gene therapy; mice; nanocarriers; neoplasm antigens; ovarian neoplasms; remission; secretion; toxicity
Abstract:
... Bispecific T-Cell Engagers (BiTEs) are effective at inducing remission in hematologic cancers, but their use in solid tumors has been challenging due to their extreme potency and on-target, off-tumor toxicities in healthy tissue. Their deployment against solid tumors is further complicated by insufficient drug penetration, a hostile tumor microenvironment, and immune escape. To address these chall ...
DOI:
10.1016/j.jconrel.2021.12.029

21. Bioactive secondary metabolites in Paris polyphylla Sm. and their biological activities: A review

Author:
Chandra Bahadur Thapa; Mukti Ram Paudel; Hari Data Bhattarai; Krishna Kumar Pant; Hari Prasad Devkota; Yagya Prasad Adhikari; Bijaya Pant
Source:
Heliyon 2022 v.8 no.2 pp. e08982
ISSN:
2405-8440
Subject:
Ayurvedic medicine; Paris polyphylla; anthelmintics; antineoplastic activity; antioxidants; diosgenin; drug therapy; habitat destruction; secondary metabolites; trade
Abstract:
... Paris polyphylla Sm. is an important medicinal plant used to treat a variety of diseases through traditional medicine systems such as Ayurveda, Tibetan traditional medicines, Chinese traditional medicines, and others around the world. The IUCN red list has designated it as "vulnerable" due to a decline in wild population by over-exploitation, habitat degradation, illegal collection for trade and t ...
DOI:
10.1016/j.heliyon.2022.e08982

22. Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

Author:
Anamika Bhaumik; Atanu Bhattacharjee; Surya Bali Prasad
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100211
ISSN:
2667-0313
Subject:
antineoplastic activity; antioxidant activity; ascites; betulinic acid; computer simulation; glutathione; longevity; lymphoma; membrane potential; mice; mitochondrial membrane; succinate dehydrogenase (quinone)
Abstract:
... Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid. Changes in glutathione and some glutathione-related enzymes and mitochondrial membrane potential have not been explored relating to the anticancer activity of betulinic acid against murine ascites Dalton ...
DOI:
10.1016/j.phyplu.2021.100211

23. Biological activities of Egyptian grape and mulberry by-products and their potential use as natural sources of food additives and nutraceuticals foods

Author:
Hanan H. Abdel-Khalek; Zakaria Ahmed Mattar
Source:
Journal of food measurement & characterization 2022 v.16 no.2 pp. 1559-1571
ISSN:
2193-4126
Subject:
COVID-19 infection; antibacterial properties; antineoplastic activity; antioxidants; crude fiber; crude protein; dietary supplements; flavonoids; grapes; measurement; mulberries; nutritive value
Abstract:
... Interest in the biological role of bioactive compounds present in plant by-products has increased over the last few years. This study aimed to investigate the nutritive value and biological activities of Egyptian Grape leaves (GL), Grape seeds (GS) and Mulberry leaves (ML), as well as investigate the impact of γ-irradiation for improving the utilization of these plant by-products. The dose level 5 ...
DOI:
10.1007/s11694-022-01289-2

24. Blue is not enough: biological activities of C‐phycocyanin extracts from Anabaena cylindrica

Author:
Inês PE Macário; Telma Veloso; Andreia PM Fernandes; Margarida Martins; Tânia R Dias; Helena Oliveira; Fernando JM Gonçalves; Sónia PM Ventura; Joana L Pereira
Source:
Journal of chemical technology and biotechnology 2022 v.97 no.5 pp. 1171-1179
ISSN:
0268-2575
Subject:
Anabaena cylindrica; Spirulina; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; biomass; biotechnology; dyes; feedstocks; freeze drying; phycocyanin
Abstract:
... BACKGROUND: Natural products are currently in the spotlight due to the increasing awareness of consumers. Among these products is phycocyanin (C‐PC), a blue colorant that can be extracted from cyanobacteria – a poorly explored feedstock – and applied in several fields, due to its argued health benefits. Arthropira (previously called Spirulina) is the major source of C‐PC nowadays, but within the s ...
DOI:
10.1002/jctb.7001

25. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia

Author:
Natsuki Imayoshi; Makoto Yoshioka; Kuniaki Tanaka; Shyh-Ming Yang; Koshi Akahane; Yuki Toda; Shigekuni Hosogi; Takeshi Inukai; Seiji Okada; David J. Maloney; Tatsutoshi Nakahata; Junko Takita; Itaru Kato; Eishi Ashihara
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 49-54
ISSN:
0006-291X
Subject:
acetyltransferases; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cyclic AMP; genes; histones; interphase; ligands; luminescence; lymphocytic leukemia; mice; protein synthesis; research; xenotransplantation
Abstract:
... Acute lymphoblastic leukemia with chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene (MLL-r ALL) remains an incurable disease. Thus, development of a safe and effective therapeutic agent to treat this disease is crucial to address this unmet medical need. BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, and cyclic AMP response element bindin ...
DOI:
10.1016/j.bbrc.2021.12.078

26. Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation

Author:
Rossella Di Guida; Angela Casillo; Antonietta Stellavato; Soichiro Kawai; Takuya Ogawa; Celeste Di Meo; Jun Kawamoto; Tatsuo Kurihara; Chiara Schiraldi; Maria Michela Corsaro
Source:
Carbohydrate polymers 2022 v.278 pp. 118908
ISSN:
0144-8617
Subject:
Pseudoalteromonas nigrifaciens; antineoplastic activity; apoptosis; biocompatible materials; biodegradability; bioinformatics; caspases; colorectal neoplasms; drug therapy; fish; immunotherapy; intestines; morbidity; mortality; polymers; polysaccharides; psychrotrophic bacteria; radiotherapy; spectroscopy; surgery; toxicity
Abstract:
... Among the widespread malignancies colorectal cancer is the most lethal. Treatments of this malignant tumor include surgery for lesions and metastases, radiotherapy, immunotherapy, and chemotherapy. Nevertheless, novel therapies to reduce morbidity and mortality are demanding. Natural products, such as polysaccharides, can be a valuable alternative to sometimes very toxic chemotherapeutical agents, ...
DOI:
10.1016/j.carbpol.2021.118908

27. Cardiac Glycosides: Distribution, Properties and Specificity of Formation in Plant Cell and Organ Cultures In Vitro

Author:
S. V. Tomilova; A. V. Kitashov; A. M. Nosov
Source:
Russian journal of plant physiology 2022 v.69 no.3 pp. 41
ISSN:
1021-4437
Subject:
antineoplastic activity; biosynthesis; cardiac glycosides; cell differentiation; medicinal plants; medicine; plant physiology; secondary metabolites
Abstract:
... Secondary metabolism (the formation of substances of specialized metabolism) is one of the distinctive specificities of the plant organism. Data on complete sequences of plant genomes indicate that from 15 to 25% of all genes are involved in this process (the biosynthesis of enzymes, transporters and transfactors serving it), while many aspects of secondary metabolism, including its physiological ...
DOI:
10.1134/S1021443722030165

28. Carrier free nanomedicine for synergistic cancer therapy by initiating apoptosis and paraptosis

Author:
Rongrong Zheng; Yibin Liu; Baixue Yu; Linping Zhao; Ni Yang; Ali Chen; Lin Xu; Hong Cheng; Xueyan Jiang; Shiying Li
Source:
Journal of colloid and interface science 2022 v.622 pp. 298-308
ISSN:
0021-9797
Subject:
antineoplastic activity; apoptosis; biocompatibility; cancer therapy; mitochondria; nanomedicine; neoplasms; photochemotherapy; toxicity
Abstract:
... Although photodynamic therapy (PDT) has been well-known as a promising anti-tumor treatment, its limited therapeutic efficiency remains to be a large challenge. In this study, a carrier free nanomedicine (designated as PyroMor) is developed to greatly initiate cell apoptosis and paraptosis for synergistic cancer therapy. Pyropheophorbide-a (Pyro) and morusin (Mor) are capable of self-assembling in ...
DOI:
10.1016/j.jcis.2022.04.090

29. Cellulose nanocrystals: Fundamentals and biomedical applications

Author:
Prajakta Mali; Atul P. Sherje
Source:
Carbohydrate polymers 2022 v.275 pp. 118668
ISSN:
0144-8617
Subject:
antibacterial properties; antineoplastic activity; antiviral properties; biodegradability; bioimaging; biosensors; cellulose; cotton; crystal structure; drugs; flax; gene transfer; hydrophilicity; immobilized enzymes; lipids; nanocrystals; surface area; tensile strength; wood
Abstract:
... The present review explores the recent developments of cellulose nanocrystals, a class of captivating nanomaterials in variety of applications. CNCs are made by acid hydrolysing cellulosic materials like wood, cotton, tunicate, flax fibers by sonochemistry. It has many desirable properties, including a high tensile strength, wide surface area, stiffness, exceptional colloidal stability, and the ab ...
DOI:
10.1016/j.carbpol.2021.118668

30. Chemical Profiling and Evaluation of Antioxidant and Anticancer Potential of Tuber Crop Amorphophallus commutatus var. wayanadensis

Author:
Sreena Raj; Rama Jayaraj; Gothandam Kodiveri Muthukaliannan
Source:
Plant foods for human nutrition 2022 v.77 no.1 pp. 68-76
ISSN:
0921-9668
Subject:
Amorphophallus; DNA fragmentation; antineoplastic activity; antioxidant activity; apoptosis; ascites; carcinoma; caspase-3; cell cycle checkpoints; cytotoxicity; dietary supplements; fractionation; functional foods; health services; hematologic tests; herbaceous plants; human cell lines; human nutrition; longevity; therapeutics; toxicity testing; India
Abstract:
... Cancer and cancer-related diseases are a global health concern in the present scenario. Functional food and nutraceuticals are considered as a boon towards cancer management. Amorphophallus commutatus var. wayanadensis (ACW) is an herbaceous plant used by the local communities of Wayanad, India, for food and primary healthcare. Various radical scavenging and reducing power assays were undertaken t ...
DOI:
10.1007/s11130-021-00942-3

31. Chemical composition, antimicrobial activity and cytotoxicity of Murraya paniculata (L.) Jack leaf essential oil from Assam, India: the effect of oil on cellular morphology of micro-organisms

Author:
Snigdha Saikia; Kashyap J. Tamuli; Bardwi Narzary; Manobjyoti Bordoloi; Dipanwita Banik
Source:
Archives of microbiology 2022 v.204 no.1 pp. 99
ISSN:
0302-8933
Subject:
Murraya paniculata; Mycobacterium smegmatis; Pseudomonas aeruginosa; anti-infective agents; antibacterial properties; antineoplastic activity; chemical composition; cytotoxicity; deformation; drug therapy; essential oils; health services; humans; leaves; microorganisms; neoplasm cells; oils; ornamental plants; spices; India
Abstract:
... Murraya paniculata (L.) Jack is commonly cultivated as ornamental plant in Assam and has been used as spice and phytomedicine traditionally for many healthcare purposes. The therapeutic potential and chemical constituents of the essential oil of M. paniculata leaf was investigated against several pathogenic microbial species and human cancer cell lines. 29 chemical compounds were identified by GC– ...
DOI:
10.1007/s00203-021-02665-0

32. Chemopreventive and Anti-tumor Potential of Natural Products in Oral Cancer

Author:
Andrés Cardona-Mendoza; Geovanny Olivares-Niño; David Díaz-Báez; Gloria Inés Lafaurie; Sandra J. Perdomo
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 779-795
ISSN:
1532-7914
Subject:
alcohol drinking; antineoplastic activity; apoptosis; chemoprevention; drug therapy; humans; mouth neoplasms; nutrition; radiotherapy; surgery; survival rate; tobacco
Abstract:
... Oral cancer (OC) is a multifactorial disease caused by isolated or combined risk factors related to tobacco, alcohol consumption, and human papillomavirus infection. It is an aggressive pathology with a low five-year survival rate after surgery, chemotherapy, and/or radiotherapy, frequently associated with severe side effects. Drugs with the highest anti-tumor effect are obtained from natural prod ...
DOI:
10.1080/01635581.2021.1931698

33. Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells

Author:
Lingling Zhang; Bing Liang; Huan Xu; Yanju Gong; Wangming Hu; Zhong Jin; Xiao Wu; Xiongbin Chen; Min Li; Liangqin Shi; Yaping Shi; Yong Wang; Lan Yang
Source:
Journal of ethnopharmacology 2022 v.291 pp. 115095
ISSN:
0378-8741
Subject:
B-lymphocytes; Bufo; Oriental traditional medicine; Western blotting; analgesia; antineoplastic activity; apoptosis; cadherins; cancer therapy; cell proliferation; cell viability; cytotoxicity; drugs; flow cytometry; fluorescent antibody technique; heart failure; histones; immunohistochemistry; lung neoplasms; methyltransferases; mice; pain; secretion; tumor suppressor genes; xenotransplantation; China
Abstract:
... Bufonis (VB), an animal drug called Chansu in China, is the product of the secretion of Bufo gargarizans Cantor or B. melanostictus Schneider. As a traditional Chinese medicine (TCM) for a long time, it has been widely used in the treatment of heart failure, ulcer, pain, and various cancers. Cinobufaginn (CNB), the cardiotonic steroid or bufalene lactone extracted from VB, has the effects of detox ...
DOI:
10.1016/j.jep.2022.115095

34. Combined effect of heat shock protein inhibitor geldanamycin and free radicals on photodynamic therapy of prostate cancer

Author:
Qinyan Sun; Fengyu Liu; Zhenfu Wen; Jing Xia; Hongjuan Li; Yongqian Xu; Shiguo Sun
Source:
Journal of materials chemistry B 2022 v.10 no.9 pp. 1369-1377
ISSN:
2050-7518
Subject:
androgen receptors; antineoplastic activity; apoptosis; cancer therapy; chemistry; death; fever; heat tolerance; heat-shock protein 90; irradiation; neoplasm cells; photochemotherapy; pro-apoptotic proteins; propane; prostatic neoplasms; reactive oxygen species; toxicity
Abstract:
... Prostate cancer is the most common malignancy and the second leading cause of cancer-induced death among men. Recently, photodynamic therapy (PDT) has attracted great attention in prostate cancer treatment because of its high accuracy and no trauma. However, the hypoxic microenvironment of the tumor severely reduces the therapeutic efficacy of oxygen-dependent PDT in prostate cancer, which hampers ...
DOI:
10.1039/d1tb02219a

35. Combined nano cancer immunotherapy based on immune status in a tumor microenvironment

Author:
Takashi Nakamura; Kyoko Kawakami; Momoka Nomura; Yusuke Sato; Mamoru Hyodo; Hiroto Hatakeyama; Yoshihiro Hayakawa; Hideyoshi Harashima
Source:
Journal of controlled release 2022 v.345 pp. 200-213
ISSN:
0168-3659
Subject:
adjuvants; antibodies; antineoplastic activity; gene expression; humans; immune system; immunotherapy; lipids; neoplasms; prognosis; programmed cell death
Abstract:
... Since the effect of cancer immunotherapy is largely dependent on the status of the immune system in the tumor microenvironment (TME), choice of therapy and the development of new therapies based on the immune status in the TME would be predicted to be effective. Unfortunately, the development of delivery systems for such therapy has been slow. Here, we defined a parameter of immune status in TME s ...
DOI:
10.1016/j.jconrel.2022.03.026

36. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:
Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:
... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:
10.3390/plants11020194

37. Complexation mechanism between 20(R, S)‐ginsenoside Rh1 and serum albumin: Multi‐spectroscopy, in vitro cytotoxicity, and in silico investigations

Author:
Jingqi Zhao; Yuan Liang; Ziyi Zhu; Yingyi Wang; Tianzhu Guan; Jie Zhang; Tiehua Zhang
Source:
Journal of food science 2022 v.87 no.3 pp. 929-938
ISSN:
0022-1147
Subject:
antineoplastic activity; bovine serum albumin; cell proliferation; computer simulation; cytotoxicity; fluorescence; food science; ginsenosides; human serum albumin; toxicity testing
Abstract:
... As rare ginsenosides, 20(R, S)‐ginsenoside Rh1 [20(R, S)‐Rh1] are isomers and have been reported to exhibit multiple biological effects. However, the application of 20(R, S)‐Rh1 is still limited due to their poor solubilities and low bioavailabilities. Here, the complexation mechanism between 20(R, S)‐Rh1 and serum albumin (SA) was explored by a combination of multi‐spectroscopy and in silico inve ...
DOI:
10.1111/1750-3841.16053

38. Comprehensive approaches on chemical composition and biological properties of Daphne pontica L. extracts

Author:
Yasemin Celik Altunoglu; Tevfik Hasan Can; Enis Fuat Tufekci; Bahattin Deniz Altunoglu; Mehmet Cengiz Baloglu; Eulogio J. Llorent-Martínez; Gokhan Zengin
Source:
Plant biosystems 2022 v.156 no.1 pp. 116-129
ISSN:
1724-5575
Subject:
DNA; Daphne; amylases; antineoplastic activity; chemical composition; chemical constituents of plants; flavonoids; leaves; methanol; traditional medicine
Abstract:
... The genus Daphne presents great interest as a valuable source of natural agents in traditional medicine of various countries, including Turkey. In the current work, we investigated the phytochemical composition and biological properties of Daphne pontica L. extracts. Methanol extracts of roots, stems and leaves were prepared. The chemical characterization was performed by HPLC-ESI-MSⁿ, observing t ...
DOI:
10.1080/11263504.2020.1837282

39. Construction of calcium carbonate-liposome dual-film coated mesoporous silica as a delayed drug release system for antitumor therapy

Author:
Yuwen Wang; Kun Zhao; Luyao Xie; Kexin Li; Wei Zhang; Ziyue Xi; Xiyu Wang; Mingyu Xia; Lu Xu
Source:
Colloids and surfaces 2022 v.212 pp. 112357
ISSN:
0927-7765
Subject:
adsorption; antineoplastic activity; biocompatibility; blood circulation; calcium; calcium carbonate; cancer therapy; doxorubicin; drug delivery systems; hemolysis; lipid bilayers; neoplasms; pH; porous media; silica; transmission electron microscopy
Abstract:
... As is well known to all, delivering drug precisely to the tumor site is beneficial to improve antitumor effect. In this study, we reported mesoporous silica nanoparticles (MSNs) coated with dual-film of calcium carbonate (CaCO₃) and lipid bilayer (denoted as MSNs@CaCO₃@liposomes) innovatively which achieve sustained drug release anchored at tumor microenvironment and enhanced biocompatibility. The ...
DOI:
10.1016/j.colsurfb.2022.112357

40. Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Author:
Asal Jalal Abadi; Sepideh Mirzaei; Mahmood Khaksary Mahabady; Farid Hashemi; Amirhossein Zabolian; Fardin Hashemi; Pourya Raee; Shahin Aghamiri; Milad Ashrafizadeh; Amir Reza Aref; Michael R. Hamblin; Kiavash Hushmandi; Ali Zarrabi; Gautam Sethi
Source:
Phytotherapy research 2022 v.36 no.1 pp. 189-213
ISSN:
0951-418X
Subject:
Curcuma longa; DNA damage; antineoplastic activity; apoptosis; cancer therapy; cardiotoxicity; cisplatin; curcumin; cytotoxicity; drug resistance; drug therapy; inflammation; neoplasm progression; neoplasms; nephrotoxicity; neurotoxicity; ototoxicity; phytochemicals; phytotherapy; research
Abstract:
... Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, and suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) stimulates DNA damage and apoptosis in cancer chemotherapy. However, CP has adverse e ...
DOI:
10.1002/ptr.7305

41. Current emerging trends in antitumor activities of polysaccharides extracted by microwave- and ultrasound-assisted methods

Author:
Seyed Mohammad Taghi Gharibzahedi; Francisco J. Marti-Quijal; Francisco J. Barba; Zeynep Altintas
Source:
International journal of biological macromolecules 2022 v.202 pp. 494-507
ISSN:
0141-8130
Subject:
antineoplastic activity; antioxidants; apoptosis; carcinogenesis; cytotoxicity; dose response; drugs; fractionation; glucans; humans; metastasis; microwave treatment; molecular weight; neoplasm cells; selenium; solvents; sulfates; ultrasonic treatment; uronic acids
Abstract:
... This overview highlighted the in vitro and in vivo antitumor effects of polysaccharides extracted by ultrasound- and microwave-assisted solvent extraction methods. The polysaccharide fragments with stronger antiproliferation, antitumoral, and anticarcinoma effects can be identified through purification, fractionation, and bio-analytical assessments. Most of the extracted glucan-based polysaccharid ...
DOI:
10.1016/j.ijbiomac.2022.01.088

42. Cyclophosphamide-induced GPX4 degradation triggers parthanatos by activating AIFM1

Author:
Liying Liu; Bingju Liu; Guotao Guan; Rui Kang; Yunpeng Dai; Daolin Tang
Source:
Biochemical and biophysical research communications 2022 v.606 pp. 68-74
ISSN:
0006-291X
Subject:
alkylation agents; antineoplastic activity; autophagy; cyclophosphamide; ferroptosis; humans; leukemia; neoplasm cells; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; protein degradation; research; xenotransplantation
Abstract:
... Cyclophosphamide is an alkylating agent used to treat a variety of cancers, including leukemia. Here, we show a previously unrecognized role of cyclophosphamide in triggering the protein degradation of glutathione peroxidase 4 (GPX4), a phospholipid hydroperoxidase that protects cells from oxidative damage. Mechanistically, we found that the ubiquitin-proteasome system, but not autophagy, mediates ...
DOI:
10.1016/j.bbrc.2022.03.098

43. Cytotoxic activity of crude extracts and fractions of African peach (nauclea latifolia smith) stem bark on two cancer cell lines

Author:
Oluwakemi Charles-Okhe; Michael A. Odeniyi; Titilayo O. Fakeye; Omonike O. Ogbole; Toluwanimi E. Akinleye; Adekunle J. Adeniji
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100212
ISSN:
2667-0313
Subject:
Cercopithecus aethiops; Sarcocephalus latifolius; antineoplastic activity; bark; bark extracts; breast neoplasms; cell lines; colorimetry; cytotoxicity; drug therapy; ethyl acetate; fractionation; hexane; kidneys; liquid chromatography; methanol; neoplasm cells; peaches; skeletal muscle; vincristine
Abstract:
... The purpose of this research work is to investigate and establish the anticancer (cytotoxic) properties of African peach (Nauclea latifolia) stem bark extract and fractions on breast cancer cell lines (MCF-7), skeletal muscle cancer (RD) cell lines and to determine the selectivity index (SI) on normal African green monkey kidney cell lines (Vero). Crude extract and fractions obtained from acid-bas ...
DOI:
10.1016/j.phyplu.2021.100212

44. Cytotoxic activity of non-specific lipid transfer protein (nsLTP1) from Ajwain (Trachyspermum ammi) seeds

Author:
Saud O. Alshammari; Taibah Aldakhil; Qamar A. Alshammari; David Salehi; Aftab Ahmed
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 135
ISSN:
2662-7671
Subject:
Trachyspermum ammi; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; blood serum; breast neoplasms; breasts; caspase-3; cytotoxicity; half life; heat treatment; humans; lipid transfer proteins; pancreatic neoplasms; pro-apoptotic proteins; spices; temperature; thermal stability; traditional medicine
Abstract:
... BACKGROUND: Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the protein’s bioactivity undiscovered. AIM: The current study aimed to demonstrate the cytotoxic ...
DOI:
10.1186/s12906-022-03616-y

45. Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFRᵀ⁷⁹⁰ᴹ tyrosine kinase inhibitors

Author:
Nada A. A. M. Aziz; Riham F. George; Khaled El-Adl; Walaa R. Mahmoud
Source:
RSC advances 2022 v.12 no.20 pp. 12913-12931
ISSN:
2046-2069
Subject:
antineoplastic activity; computer simulation; cytotoxicity; furans; humans; mutants; neoplasm cells; thiophene; tyrosine; vascular endothelial growth factor receptor-2
Abstract:
... Fourteen recent thiazolidine-2,4-diones bearing furan and/or thiophene heterocyclic rings have been designed, synthesized and assessed for their anticancer activities against four human tumor cell lines HepG2, A549, MCF-7 and HCT-116 targeting both VEGFR-2 and EGFR tyrosine kinases. Molecular design was carried out to investigate the binding mode of the proposed compounds with VEGFR-2 and EGFR rec ...
DOI:
10.1039/d2ra01119k

46. Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS

Author:
Qingyuan Zeng; Hongfei Si; Kun Lv; Jiao Mo; Xinnian Wang; Biqing Yan; Jili Zhang
Source:
BMC veterinary research 2022 v.18 no.1 pp. 145
ISSN:
1746-6148
Subject:
acetone; acetonitrile; antineoplastic activity; chemical species; formic acid; intraperitoneal injection; mice; mitochondria; models; pharmacokinetics; tandem mass spectrometry; veterinary medicine
Abstract:
... BACKGROUND: UK-5099 is a potent mitochondrial acetone carrier inhibitor, that exhibits anticancer activity. Recently, the anti-Toxoplasma gondii activity of UK-5099 was proposed, and in vivo studies of its pharmacokinetics in BALB/c mice are necessary to further evaluate the clinical effect of UK-5099. METHODS AND RESULTS: A simple and fast high-performance liquid chromatography-tandem mass spectr ...
DOI:
10.1186/s12917-022-03245-0

47. Determination of the structure and in vitro anticancer activity of fucan from Saccharina dentigera and its derivatives

Author:
Roza V. Usoltseva; Natalia M. Shevchenko; Artem S. Silchenko; Stanislav D. Anastyuk; Nikolai V. Zvyagintsev; Svetlana P. Ermakova
Source:
International journal of biological macromolecules 2022 v.206 pp. 614-620
ISSN:
0141-8130
Subject:
Saccharina dentigera; adenocarcinoma; antineoplastic activity; autohydrolysis; fucoidan; humans; mass spectrometry; melanoma; models; nuclear magnetic resonance spectroscopy; small intestine; solvolysis; sulfates
Abstract:
... The fucoidan SdeF was isolated from brown alga Saccharina dentigera. The structure of the obtained polysaccharide was studied by chemical methods, NMR spectroscopy of the fully and partially desulfated derivatives, and mass spectrometry of the fucoidan fragments, labeled with ¹⁸O. The SdeF was shown to be sulfated (40%) 1,3-linked α-L-fucan, with branches at C2. The sulfate groups were found at po ...
DOI:
10.1016/j.ijbiomac.2022.02.126

48. Development of fortified milk with gelled-oil nanoparticles incorporated with cinnamaldehyde and tannic acid

Author:
Seyed Hossein Asadi-Yousefabad; Saeed Mohammadi; Samira Ghasemi; Kamran Saboktakin-Rizi; Shahriyar Sahraeian; Seyedeh Sahar Asadi; Mohammad Hashemi; Hamid Reza Ghaffari
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.154 pp. 112652
ISSN:
0023-6438
Subject:
antineoplastic activity; encapsulation; lungs; median effective concentration; milk; neoplasm cells; odors; oils; particle size; rheology; surface tension; tannins; viscoelasticity; zeta potential
Abstract:
... In the present work, we prepared gelled-oil nanoparticles (GLNs) to encapsulate cinnamaldehyde (CA) and/or tannic acid (TA) within the oil and aqueous phases, respectively and these systems were then used to fortify milk to enhance its health beneficial effects. Different characteristics of the carrier systems including particle size, span, zeta potential, physical stability, rheology, encapsulati ...
DOI:
10.1016/j.lwt.2021.112652

49. EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway

Author:
Hua Wei; Qi Ge; Ling-Yu Zhang; Jing Xie; Rui-Huan Gan; You-Guang Lu; Da-Li Zheng
Source:
Journal of nutritional biochemistry 2022 v.99 pp. 108843
ISSN:
0955-2863
Subject:
active ingredients; adverse effects; antineoplastic activity; apoptosis; drug therapy; epigallocatechin gallate; green tea; hyperplasia; mutants; neoplasm cells; neoplasms; tamoxifen; tongue; toxicity; xenotransplantation
Abstract:
... Epigallocatechin-3-gallate (EGCG), the main active ingredient of green tea, exhibits low toxic side effect and versatile bioactivities, and its anti-cancer effect has been extensively studied. Most of the studies used cancer cell lines and xenograft models. However, whether EGCG can prevent tumor onset after cancer-associated mutations occur is still controversial. In the present study, Krt14-cre/ ...
DOI:
10.1016/j.jnutbio.2021.108843

50. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:
Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:
Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:
0163-4984
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:
... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:
10.1007/s12011-021-02812-0