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- Wan, David
C. C., et al. Show all 7 Authors
- Journal of natural products 2015 v.78 no.9 pp. 2266-2275
- P-glycoproteins; Salvia miltiorrhiza; active sites; antineoplastic activity; apoptosis; binding capacity; cell growth; cytotoxicity; diterpenoids; doxorubicin; drug resistance; flow cytometry; growth retardation; hepatoma; human cell lines; humans; median effective concentration; mitogen-activated protein kinase; molecular models; neoplasm cells; signal transduction; synergism
- ... Miltirone (1), an abietane-type diterpene quinone isolated from Salvia miltiorrhiza, possesses anticancer activity in p-glycoprotein (P-gp)-overexpressing human cancer cells. Results of the current study suggest a dual effect of miltirone on P-gp inhibition and apoptotic induction in a human hepatoma HepG2 cell line and its P-gp-overexpressing doxorubicin-resistant counterpart (R-HepG2). Miltirone ...