Subject term: antioxidant activity and antineoplastic activity

1. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

Author:: Fazhi Su; Yanping Sun; Wenbo Zhu; Chenxi Bai; Wensen Zhang; Yumeng Luo; Bingyou Yang; Haixue Kuang; Qiuhong Wang
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114798
ISSN:: 0378-8741
Subject:: Arisaema; analgesics; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cough; epilepsy; flavonoids; germplasm; pharmacodynamics; pharmacokinetics; quality control; rheumatoid arthritis; sedatives; snake bites; tetanus; therapeutics; toxicity; toxicology; traditional medicine
Abstract:: ... The genus Arisaema belongs to the family Araceae, which includes Chinese herbal medicines with wide-ranging pharmacological functions, including those useful for the treatment of stubborn phlegm, cough, epilepsy, tetanus, snakebite, rheumatoid arthritis, and other ailments.The current study aimed to comprehensively review the botany, uses, phytochemistry, pharmacology, toxicity, quality control an ...
DOI:: 10.1016/j.jep.2021.114798
: https://doi.org/10.1016/j.jep.2021.114798

2. Aqueous two-phase extraction of polysaccharides from Selaginella doederleinii and their bioactivity study

Author:: Gang Li; Xiankui Ma; Yongmei Jiang; Weiwei Li; Yongling Wang; Li Liu; Chengxin Sun; Shiji Xiao; Jie Lan; Juxiang Kuang; Gang Wang
Source:: Process biochemistry 2022 v.118 pp. 274-282
ISSN:: 1359-5113
Subject:: Selaginella doederleinii; antineoplastic activity; antioxidant activity; antioxidants; ethanol; liquids; polysaccharides; salt concentration; thermogravimetry; ultrasonics
Abstract:: ... In this study, the ethanol/salt aqueous two-phase system was firstly used to extract Selaginella doederleinii polysaccharides (SDP). Through single factor and response surface analysis, the best extraction conditions were as follows: extraction time of 40 min, ultrasonic power of 280 W, ethanol concentration of 35%, inorganic salt concentration of 0.22 g/mL, and liquid/solid ratio of 25 mL/g with ...
DOI:: 10.1016/j.procbio.2022.04.024
: https://doi.org/10.1016/j.procbio.2022.04.024

3. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris—In Vitro and In Vivo Studies

Author:: Malik Waseem Abbas; Mazhar Hussain; Saeed Akhtar; Tariq Ismail; Muhammad Qamar; Zahid Shafiq; Tuba Esatbeyoglu
Source:: Antioxidants 2022 v.11 no.6 pp. -
ISSN:: 2076-3921
Subject:: Tribulus terrestris; antineoplastic activity; antioxidant activity; blood serum; body weight; breast neoplasms; denaturation; drugs; edema; egg albumen; hemolysis; histopathology; metabolites; methanol; mice; myricetin; neoplasm cells; rutin; serum albumin; toxicity
Abstract:: ... Tribulus terrestris L. belongs to the family Zygophyllaceae and integral part of various ancient medicinal systems including Chinese, Indian, and European to combat various health ailments. The aim of the present study was to assess the phytochemical constituents, in vitro antioxidant activity using DPPH, FRAP, and H₂O₂ assays, in vitro anticancer activity using MTT assay, and in vitro and in vivo ...
DOI:: 10.3390/antiox11061160
: https://doi.org/10.3390/antiox11061160

4. Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

Author:: Anamika Bhaumik; Atanu Bhattacharjee; Surya Bali Prasad
Source:: Phytomedicine plus 2022 v.2 no.1 pp. 100211
ISSN:: 2667-0313
Subject:: antineoplastic activity; antioxidant activity; ascites; betulinic acid; computer simulation; glutathione; longevity; lymphoma; membrane potential; mice; mitochondrial membrane; succinate dehydrogenase (quinone)
Abstract:: ... Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid. Changes in glutathione and some glutathione-related enzymes and mitochondrial membrane potential have not been explored relating to the anticancer activity of betulinic acid against murine ascites Dalton ...
DOI:: 10.1016/j.phyplu.2021.100211
: https://doi.org/10.1016/j.phyplu.2021.100211

5. Blue is not enough: biological activities of C‐phycocyanin extracts from Anabaena cylindrica

Author:: Inês PE Macário; Telma Veloso; Andreia PM Fernandes; Margarida Martins; Tânia R Dias; Helena Oliveira; Fernando JM Gonçalves; Sónia PM Ventura; Joana L Pereira
Source:: Journal of chemical technology and biotechnology 2022 v.97 no.5 pp. 1171-1179
ISSN:: 0268-2575
Subject:: Anabaena cylindrica; Spirulina; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; biomass; biotechnology; dyes; feedstocks; freeze drying; phycocyanin
Abstract:: ... BACKGROUND: Natural products are currently in the spotlight due to the increasing awareness of consumers. Among these products is phycocyanin (C‐PC), a blue colorant that can be extracted from cyanobacteria – a poorly explored feedstock – and applied in several fields, due to its argued health benefits. Arthropira (previously called Spirulina) is the major source of C‐PC nowadays, but within the s ...
DOI:: 10.1002/jctb.7001
: https://doi.org/10.1002/jctb.7001

6. Chemical Profiling and Evaluation of Antioxidant and Anticancer Potential of Tuber Crop Amorphophallus commutatus var. wayanadensis

Author:: Sreena Raj; Rama Jayaraj; Gothandam Kodiveri Muthukaliannan
Source:: Plant foods for human nutrition 2022 v.77 no.1 pp. 68-76
ISSN:: 0921-9668
Subject:: Amorphophallus; DNA fragmentation; antineoplastic activity; antioxidant activity; apoptosis; ascites; carcinoma; caspase-3; cell cycle checkpoints; cytotoxicity; dietary supplements; fractionation; functional foods; health services; hematologic tests; herbaceous plants; human cell lines; human nutrition; longevity; therapeutics; toxicity testing; India
Abstract:: ... Cancer and cancer-related diseases are a global health concern in the present scenario. Functional food and nutraceuticals are considered as a boon towards cancer management. Amorphophallus commutatus var. wayanadensis (ACW) is an herbaceous plant used by the local communities of Wayanad, India, for food and primary healthcare. Various radical scavenging and reducing power assays were undertaken t ...
DOI:: 10.1007/s11130-021-00942-3
: https://doi.org/10.1007/s11130-021-00942-3

7. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:: Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:: Plants 2022 v.11 no.2 pp. -
ISSN:: 2223-7747
Subject:: Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:: ... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:: 10.3390/plants11020194
: https://doi.org/10.3390/plants11020194

8. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:: Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:: Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:: 0163-4984
Subject:: Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:: ... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:: 10.1007/s12011-021-02812-0
: https://doi.org/10.1007/s12011-021-02812-0

9. Effects of sulfation and carboxymethylation on Cyclocarya paliurus polysaccharides: Physicochemical properties, antitumor activities and protection against cellular oxidative stress

Author:: Liuming Xie; Zhibing Huang; Li Qin; Qiang Yu; Yi Chen; Haibing Zhu; Jianhua Xie
Source:: International journal of biological macromolecules 2022 v.204 pp. 103-115
ISSN:: 0141-8130
Subject:: Cyclocarya paliurus; antineoplastic activity; antioxidant activity; apoptosis; cell cycle checkpoints; cell viability; glucose; interphase; lactate dehydrogenase; malondialdehyde; neoplasms; oxidative stress; phagocytosis; polysaccharides; secretion; superoxide dismutase
Abstract:: ... The Cyclocarya paliurus polysaccharide (CP) was chemically modified to produce sulfated derivatives (S-CP) and carboxymethylated derivatives (CM-CP). Subsequently, the antioxidant activity, cytoprotective effect and antitumor activity of these derivatives were investigated to establish the relationship between their structure and functional activity. The results found that chemical modifications r ...
DOI:: 10.1016/j.ijbiomac.2022.01.192
: https://doi.org/10.1016/j.ijbiomac.2022.01.192

10. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

Author:: Sahil Kapoor; Hemant Sood; Shweta Saxena; Om Prakash Chaurasia
Source:: Bioprocess and biosystems engineering 2022 v.45 no.2 pp. 365-380
ISSN:: 1615-7591
Subject:: Hordeum vulgare; Rhodiola; Withania somnifera; agricultural industry; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bioprocessing; carotenoids; cell lines; cell viability; chlorophyll; cytotoxicity; dose response; germination; nanosilver; neoplasm cells; p-nitrophenol; photosynthesis; pollutants; pollution; remediation; root extracts; silver nitrate; sustainable technology; zeta potential
Abstract:: ... This study presents the development of a sustainable production process of environmentally benign silver nanoparticles (AgNPs) from aqueous root extract of Rhodiola imbricata (RI) and Withania somnifera (WS) for mitigating environmental pollution and investigating their potential applications in agriculture and biomedical industry. RIWS-AgNPs were characterized using several analytical techniques ...
DOI:: 10.1007/s00449-021-02666-9
: https://doi.org/10.1007/s00449-021-02666-9

11. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

Author:: Xuelin Mo; Dongkai Guo; Yiguo Jiang; Ping Chen; Lifeng Huang
Source:: International journal of biological macromolecules 2022 v.199 pp. 212-222
ISSN:: 0141-8130
Subject:: Oriental traditional medicine; antineoplastic activity; antioxidant activity; dose response; flavonoids; glycemic effect; glycosides; immunity; intestinal microorganisms; medicinal plants; molecular weight; phenylpropanoids; polysaccharides; structure-activity relationships; therapeutics; China
Abstract:: ... Radix Hedysari, a well-known traditional Chinese herbal medicine, has a long history as a medicinal plant in China based on its wide spectrum of biological and pharmacological activities. Until now, many chemical constituents have been isolated and identified from Radix Hedysari, such as polysaccharides, flavonoids, phenylpropanoids, trace elements and so on. Of these, Radix Hedysari polysaccharid ...
DOI:: 10.1016/j.ijbiomac.2021.12.095
: https://doi.org/10.1016/j.ijbiomac.2021.12.095

12. Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

Author:: Michal Dziadek; Kinga Dziadek; Szymon Salagierski; Mariola Drozdowska; Andrada Serafim; Izabela-Cristina Stancu; Piotr Szatkowski; Aneta Kopec; Izabella Rajzer; Timothy E.L. Douglas; Katarzyna Cholewa-Kowalska
Source:: Carbohydrate polymers 2022 v.290 pp. 119486
ISSN:: 0144-8617
Subject:: antineoplastic activity; antioxidant activity; antioxidants; chitosan; crosslinking; cytotoxicity; glass; hydrogels; mineralization; pectins; rosmarinic acid; strength (mechanics); therapeutics
Abstract:: ... Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications. However, most studies have focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass ...
DOI:: 10.1016/j.carbpol.2022.119486
: https://doi.org/10.1016/j.carbpol.2022.119486

13. Novel studies of characterization, antioxidant, anticoagulant and anticancer activity of purified polysaccharide from Hypsizygus ulmarius mushroom

Author:: Alamelu Thimmaraju; Sudha Govindan
Source:: Bioactive carbohydrates and dietary fibre 2022 v.27 pp. 100308
ISSN:: 2212-6198
Subject:: Fourier transform infrared spectroscopy; Hypsizygus; anticoagulants; antineoplastic activity; antioxidant activity; cytotoxicity; dietary fiber; galactose; gas chromatography-mass spectrometry; gel chromatography; glucose; high performance liquid chromatography; ion exchange chromatography; mannose; molecular weight; mushrooms; nuclear magnetic resonance spectroscopy; polysaccharides; rhamnose; superoxide anion; water solubility
Abstract:: ... A water-soluble polysaccharide (HUP-2) was isolated from H. ulmarius using hot water extraction and purified using ion exchange chromatography (DEAE cellulose-52) and gel filtration (Sepharose-6B). The structure characteristics of HUP-2 were investigated using high performance liquid chromatography (HPLC), Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) spectrum, and gas chrom ...
DOI:: 10.1016/j.bcdf.2022.100308
: https://doi.org/10.1016/j.bcdf.2022.100308

14. Study of physicochemical, nutritional, and anticancer activity of Murraya Koenigii extract for its fermented beverage

Author:: Shriya Bhatt; Vikas Dadwal; Yogendra Padwad; Mahesh Gupta
Source:: Journal of food processing and preservation 2022 v.46 no.1 pp. e16137
ISSN:: 0145-8892
Subject:: Bergera koenigii; Murraya; antineoplastic activity; antioxidant activity; antioxidants; curry; fermentation; fermented beverages; flavonoids; food intake; free amino acids; health promotion; indigenous knowledge; neoplasm cells; nutrition assessment; oxidative stress; polyphenols; quantitative analysis; ultra-performance liquid chromatography
Abstract:: ... Murraya koenigii L (Curry) leaves, known for its natural polyphenols, possess efficient antioxidant properties that maintain oxidative stress and promote health benefits. Higher content of phenolics (77.00 µg GAE/mg) and flavonoids (21.02 µg RU/mg) was detected in M. koenigii leaves extract along with ultra‐performance liquid chromatography quantification (UPLC) followed by antioxidant activity. T ...
DOI:: 10.1111/jfpp.16137
: https://doi.org/10.1111/jfpp.16137

15. The exploitation of rice husk biomass for the bio-inspired synthesis of gold nanoparticles as a multifunctional material for various biological and photocatalytic applications

Author:: Asmaa G. Harby; Ola M. El-Borady; Maged El-Kemary
Source:: Bioprocess and biosystems engineering 2022 v.45 no.1 pp. 61-74
ISSN:: 1615-7591
Subject:: Candida albicans; Staphylococcus aureus; absorption; adenocarcinoma; antineoplastic activity; antioxidant activity; biomass; bioprocessing; biosynthesis; cell lines; methylene blue; nanogold; neoplasm cells; p-nitrophenol; pH; photocatalysis; phytochemicals; plant extracts; rice; rice hulls; spectral analysis; surface plasmon resonance; temperature; thermal stability
Abstract:: ... We report an efficient and facile approach to biosynthesis of gold nanoparticles (AuNPs) using the extract of an agro-waste rice husk generated from rice production. The biosynthesized NPs produced were characterized by UV–Visible absorption, TEM, XRD, EDX, and FTIR methods. The impact of temperature and pH on the stability of the synthesized AuNPs was also studied. The TEM imaging revealed the fo ...
DOI:: 10.1007/s00449-021-02639-y
: https://doi.org/10.1007/s00449-021-02639-y

16. A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species

Author:: Mariana Oalđe Pavlović; Stoimir Kolarević; Jelena Đorđević; Jovana Jovanović Marić; Tanja Lunić; Marija Mandić; Margareta Kračun Kolarević; Jelena Živković; Ana Alimpić Aradski; Petar D. Marin; Katarina Šavikin; Branka Vuković-Gačić; Biljana Božić Nedeljković; Sonja Duletić-Laušević
Source:: Plants 2021 v.10 no.11 pp. -
ISSN:: 2223-7747
Subject:: Escherichia coli; Melissa officinalis; Ocimum basilicum; Rosmarinus officinalis; Salmonella Typhimurium; Salvia officinalis; Satureja montana; antineoplastic activity; antioxidant activity; colorectal neoplasms; fibroblasts; genotoxicity; humans; lungs; mutagens; nitric oxide; plasmids; polyphenols; quercetin; reactive oxygen species; rosmarinic acid; rutin
Abstract:: ... This study was designed to evaluate the genoprotective, antigenotoxic, as well as antitumor potential of methanolic, ethanolic, and aqueous extracts of Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, and Satureja montana (Lamiaceae), in different model systems. The polyphenols in these extracts were quantified both spectrophotometrically and us ...
DOI:: 10.3390/plants10112306
: https://doi.org/10.3390/plants10112306

17. A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Author:: Şeyda Berk; Savaş Kaya; Esra Küpeli Akkol; Hilal Bardakçı
Source:: Phytomedicine 2022 v.98 pp. 153938
ISSN:: 0944-7113
Subject:: Lewis acids; antimicrobial properties; antineoplastic activity; antioxidant activity; density functional theory; epidemiology; flavonoids; glycemic effect; hardness; lung neoplasms; lungs
Abstract:: ... It is well-known that flavonoids, which can be easily obtained from many fruits and vegetables are widely preferred in the treatment of some important diseases. Some researchers noted that these chemical compounds exhibit high inhibition effect against various cancer types. Many experimental studies proving this ability of the flavonoids with high antioxidant activity are available in the literatu ...
DOI:: 10.1016/j.phymed.2022.153938
: https://doi.org/10.1016/j.phymed.2022.153938

18. A novel biogenic Allium cepa leaf mediated silver nanoparticles for antimicrobial, antioxidant, and anticancer effects on MCF-7 cell line

Author:: M. Mani; Mohammad K. Okla; S. Selvaraj; A. Ram Kumar; S. Kumaresan; Azhaguchamy Muthukumaran; K. Kaviyarasu; Mohamed A. El-Tayeb; Yahya B. Elbadawi; Khalid S. Almaary; Bander Mohsen Ahmed Almunqedhi; Mohamed Soliman Elshikh
Source:: Environmental research 2021 v.198 pp. 111199
ISSN:: 0013-9351
Subject:: Allium cepa; Bacillus cereus; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antineoplastic activity; antioxidant activity; antioxidants; biosynthesis; breast neoplasms; cytotoxicity; energy-dispersive X-ray analysis; human cell lines; leaf extracts; leaves; nanosilver; neoplasm cells; research; silver; silver nitrate; toxicity testing; transmission electron microscopy; ultraviolet-visible spectroscopy; zeta potential
Abstract:: ... In the present study, Allium cepa leaf extract was utilized to reduce the silver nitrate into the nanoscale range of silver ions (Ag NPs). The biosynthesized Ag NPs were extensively characterized by X-ray diffraction analysis (XRD), Dynamic light scattering analysis (DLS), UV–Visible spectroscopy (UV–vis), Transmission electron microscopy (TEM), Energy dispersive X-ray analysis (EDX) and Fourier t ...
DOI:: 10.1016/j.envres.2021.111199
: https://doi.org/10.1016/j.envres.2021.111199

19. Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves

Author:: Masuma Akter; Mst. Shahnaj Parvin; Md. Mahadi Hasan; Md. Aziz Abdur Rahman; Md. Ekramul Islam
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 169
ISSN:: 2662-7671
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Pithecellobium dulce; alternative medicine; antineoplastic activity; antioxidant activity; antioxidants; ascites; body weight; cell growth; chromatography; drug therapy; erythrocytes; ethyl acetate; fluorescence microscopes; free radicals; growth retardation; hemolysis; humans; lipid peroxidation; lipids; methanol; models; neoplasm cells; oxidation; plasmids; trees; vincristine; water solubility
Abstract:: ... BACKGROUND: Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biologically active compounds. The present study was designed to isolate pure compound from ethyl acetate fraction of methanol extract of leaves and to know the efficacy as antioxidant a ...
DOI:: 10.1186/s12906-022-03633-x
: https://doi.org/10.1186/s12906-022-03633-x

20. Antibacterial activity of ethyl acetate extract of endophytic fungus (Paraconiothyrium brasiliense) through targeting dihydropteroate synthase (DHPS)

Author:: Anbazhagan Sathiyaseelan; Kandasamy Saravanakumar; Arokia Vijaya Anand Mariadoss; Kristine M. Kim; Myeong-Hyeon Wang
Source:: Process biochemistry 2021 v.111 pp. 27-35
ISSN:: 1359-5113
Subject:: Capsicum annuum; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; cell viability; cytotoxicity; endophytes; ethyl acetate; flavonoids; fruits; fungi; limonene; metabolites; prostatic neoplasms; tetracycline
Abstract:: ... Endophytic fungi are innumerable sources of bioactive metabolites with various biomedical applications. Hence, this study was aimed to isolate and identify the endophytic fungus Paraconiothyrium brasiliense (PB) from the fruit of Capsicum annuum and evaluated their biochemical, antimicrobial, antioxidant, cell viability, and cytotoxicity behavior. Results showed that ethyl acetate extract (EAE) of ...
DOI:: 10.1016/j.procbio.2021.10.010
: https://doi.org/10.1016/j.procbio.2021.10.010

21. Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy

Author:: Yongkyu Lee; Jehyung Lee; Changbaek Lim
Source:: Food science and biotechnology 2021 v.30 no.3 pp. 321-340
ISSN:: 1226-7708
Subject:: animals; antineoplastic activity; antioxidant activity; apigenin; bioavailability; biotechnology; drug therapy; epigallocatechin gallate; food science; genistein; hesperetin; kaempferol; luteolin; quercetin; redox potential
Abstract:: ... Since researchers began studying the mechanism of flavonoids’ anticancer activity, little attention has been focused on the modulation of redox state in cells as a potential chemotherapeutic strategy. However, recent studies have begun identifying that the anticancer effect of flavonoids occurs both in their antioxidative activity which scavenges ROS and their prooxidative activity which generates ...
DOI:: 10.1007/s10068-021-00899-8
: https://doi.org/10.1007/s10068-021-00899-8

22. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated

Author:: Shabir Ahmad Ganai; Farooq Ahmad Sheikh; Zahoor Ahmad Baba; Mudasir Ahmad Mir; Mohd Ayoob Mantoo; Manzoor Ahmad Yatoo
Source:: Phytotherapy research 2021 v.35 no.7 pp. 3509-3532
ISSN:: 0951-418X
Subject:: DNA methylation; antineoplastic activity; antioxidant activity; brain neoplasms; breast neoplasms; colorectal neoplasms; cytotoxicity; epigenetics; histone deacetylase; liver; lung neoplasms; luteolin; melanoma; pancreatic neoplasms; phytotherapy; prostatic neoplasms; research
Abstract:: ... Various signaling mechanisms contribute significantly to the development of multiple cancers. Small molecules with the potential of influencing a wide variety of molecular targets may prove as broad‐spectrum anticancer agents. Flavonoids from plant sources are strongly emerging as promising antineoplastic molecules because of their ability to hamper different cancer‐driving signaling pathways. Fur ...
DOI:: 10.1002/ptr.7044
: https://doi.org/10.1002/ptr.7044

23. Anticancer property of Selaginella bryopteris (L.) Bak. against hepatocellular carcinoma in vitro and in vivo

Author:: Lal Chand Pal; Arti Gautam; Veena Pande; Ch V Rao
Source:: Phytomedicine plus 2022 v.2 no.1 pp. 100201
ISSN:: 2667-0313
Subject:: Selaginella bryopteris; acute toxicity; animal models; antineoplastic activity; antioxidant activity; apoptosis; carbon tetrachloride; caspase-3; caspase-9; catalase; cell viability; chemical constituents of plants; diethylnitrosamine; drugs; gallic acid; gas chromatography-mass spectrometry; gene expression; genes; hepatoma; histology; human cell lines; humans; imidazole; liver; liver function; lupeol; membrane potential; mitochondrial membrane; mortality; myo-inositol; neoplasm cells; palmitic acid; reactive oxygen species; reverse transcriptase polymerase chain reaction; silymarin; therapeutics; toxicity testing
Abstract:: ... Hepatocellular carcinoma (HCC) is the most common and leading cause of cancer-related mortality worldwide. It has limited therapeutic options and side effects caused by current treatment methods. Selaginella bryopteris is used traditionally in the treatment of several health-related problems but mostly remains to be scientific validation. This study investigated the effect of Selaginella bryopteri ...
DOI:: 10.1016/j.phyplu.2021.100201
: https://doi.org/10.1016/j.phyplu.2021.100201

24. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:: Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:: 2662-7671
Subject:: Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:: ... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:: 10.1186/s12906-022-03526-z
: https://doi.org/10.1186/s12906-022-03526-z

25. Antioxidant activity of two edible isothiocyanates: Sulforaphane and erucin is due to their thermal decomposition to sulfenic acids and methylsulfinyl radicals

Author:: Jakub Cedrowski; Kajetan Dąbrowa; Paweł Przybylski; Agnieszka Krogul-Sobczak; Grzegorz Litwinienko
Source:: Food chemistry 2021 v.353 pp. 129213
ISSN:: 0308-8146
Subject:: Brassicaceae; antineoplastic activity; antioxidant activity; antioxidants; behavior; chemoprevention; food chemistry; glucosinolates; lecithins; linolenic acid; oxidation; oxidative stability; sulforaphane; temperature; thermal degradation
Abstract:: ... Sulforaphane(SFN) and erucin(ERN) are isothiocyanates (ITCs) bearing, respectively, methylsulfinyl and methylsulfanyl groups. Their chemopreventive and anticancer activity is attributed to ability to modulate cellular redox status due to induction of Phase 2 cytoprotective enzymes (indirect antioxidant action) but many attempts to connect the bioactivity of ITCs with their radical trapping activit ...
DOI:: 10.1016/j.foodchem.2021.129213
: https://doi.org/10.1016/j.foodchem.2021.129213

26. Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer

Author:: Cristina Mesas; Rosario Martínez; Raúl Ortíz; Milagros Galisteo; María López-Jurado; Laura Cabeza; Gloria Perazzoli; Consolación Melguizo; Jesús M. Porres; Jose Prados
Source:: Nutrients 2021 v.13 no.2 pp. -
ISSN:: 2072-6643
Subject:: Euphorbia lathyris; antineoplastic activity; antioxidant activity; autophagy; caspases; chromatography; colorectal neoplasms; flour; glioblastoma; mechanism of action; neoplasm cells; polyphenols; therapeutics; traditional medicine
Abstract:: ... The seeds of Euphorbia lathyris have been used in traditional medicine to treat various medical conditions. However, neither all of their active biocompounds nor the molecular mechanisms underlying their therapeutic effects have been described. A new ethanolic extract of defatted flour from mature seeds of Euphorbia lathyris showed a high total polyphenol content and significant antioxidant activi ...
DOI:: 10.3390/nu13020566
: https://doi.org/10.3390/nu13020566

27. Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response

Author:: Jianhui Xie; Zhengquan Lai; Xinghan Zheng; Huijun Liao; Yanfang Xian; Qian Li; Jingjing Wu; Siupo Ip; Youliang Xie; Jiannan Chen; Ziren Su; Zhixiu Lin; Xiaobo Yang
Source:: Toxicology 2021 v.451 pp. 152680
ISSN:: 0300-483X
Subject:: Brucea javanica; acetylcysteine; adjuvants; antineoplastic activity; antioxidant activity; apoptosis; caspase-3; caspase-8; cell cycle checkpoints; drug therapy; epidermal growth factor; flow cytometry; glutathione; humans; lung neoplasms; malondialdehyde; medicinal plants; membrane potential; migratory behavior; mitochondria; mitochondrial membrane; protein synthesis; reactive oxygen species; synergism; toxicology; China
Abstract:: ... Brusatol occurs as a characteristic bioactive principle of Brucea javanica (L.) Merr., a traditional medicinal herb frequently employed to tackle cancer in China. This work endeavored to unravel the potential anti-cancer activity and action mechanism of brusatol against non-small cell lung cancer (NSCLC) cell lines. The findings indicated that brusatol remarkably inhibited the growth of wild-type ...
DOI:: 10.1016/j.tox.2021.152680
: https://doi.org/10.1016/j.tox.2021.152680

28. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

Author:: Kinjal P. Bhadresha; Nayan K. Jain; Rakesh M. Rawal
Source:: Nutrition and cancer 2022 v.74 no.3 pp. 1023-1036
ISSN:: 1532-7914
Subject:: Moringa oleifera; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioactive compounds; bioavailability; cell lines; cell viability; cytotoxicity; digestion; flavonoids; gene expression; glutathione; interphase; metastasis; polyphenols; prostatic neoplasms; protective effect; spectral analysis
Abstract:: ... Moringa oleifera possesses numerous advantageous effects like anti-microbial, antioxidant, and anti-inflammatory, leaves contain a high multiplicity of the bioactive compound; however, little is identified about its bioaccessibility. The objective of this study was to assess the bioefficacy, bioaccessible and anticancer activity of Moringa oleifera in a PC3 cell line before and after simulated in ...
DOI:: 10.1080/01635581.2021.1933099
: https://doi.org/10.1080/01635581.2021.1933099

29. Biofunctionalized silver nanoparticles synthesized from Passiflora vitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities

Author:: Dhanyakumara Shivapoojar Basavarajappa; Raju Suresh Kumar; Abdulrahman I. Almansour; Bidhayak Chakraborty; Meghashyama Prabhakara Bhat; Shashiraj Kariyellappa Nagaraja; Halaswamy Hiremath; Karthikeyan Perumal; Sreenivasa Nayaka
Source:: Biochemical engineering journal 2022 pp. 108517
ISSN:: 1369-703X
Subject:: Fourier transform infrared spectroscopy; Passiflora; X-ray diffraction; absorption; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; atomic force microscopy; cell lines; leaf extracts; macrophages; mice; nanosilver; transmission electron microscopy; zeta potential
Abstract:: ... The present study describes the synthesis of silver nanoparticles (AgNPs) using Passiflora vitifolia (P. vitifolia) leaf extract as reducing and capping agent. Characterization of the synthesized AgNPs was done with the help of UV-Vis. spectroscopy, atomic force microscopy (AFM), fourier transform infrared microscopy (FTIR), zeta potential, thermo gravimetric analysis (TGA), scanning electron micr ...
DOI:: 10.1016/j.bej.2022.108517
: https://doi.org/10.1016/j.bej.2022.108517

30. Chemical composition, antitumor and antioxidant effects of four lebanese plants extracts on human pulmonary adenocarcinoma

Author:: Alain Abi-Rizk; Youssef El Rayess; Marcello Iriti; Edouard Tabet; Roula Mezher; Marc El Beyrouthy
Source:: Natural product research 2021 v.35 no.22 pp. 4861-4864
ISSN:: 1478-6427
Subject:: Lobelia; Salvia multicaulis; Stachys; adenocarcinoma; adverse effects; alkylation; antineoplastic activity; antioxidant activity; antioxidants; cytotoxicity; death; drugs; epithelium; humans; lung neoplasms; lungs; neoplasm cells; research; viability; Lebanon
Abstract:: ... Lung cancer leading cause of humans’ cancer-related death remains incurable with current drug therapies having many side-effects. Finding new natural cancer remedies would help design better therapies. This study aims to investigate the anticancer and antioxidant effects of the Levant endemic plants Prango sasperula, Stachys ehrenbergii, Hirtellina lobelia, and Salvia multicaulis on human pulmonar ...
DOI:: 10.1080/14786419.2020.1737056
: https://doi.org/10.1080/14786419.2020.1737056

31. Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Author:: Srimanta Patra; Biswajita Pradhan; Rabindra Nayak; Chhandashree Behera; Surajit Das; Samir Kumar Patra; Thomas Efferth; Mrutyunjay Jena; Sujit Kumar Bhutia
Source:: Phytomedicine 2021 v.90 pp. 153554
ISSN:: 0944-7113
Subject:: antineoplastic activity; antioxidant activity; apoptosis; autophagy; cancer therapy; carcinogenesis; cell cycle checkpoints; chemoprevention; cytotoxicity; diet; humans; inflammation; metastasis; neoplasms; oncogenes; phytochemicals; polyphenols; risk; synergism
Abstract:: ... Epidemiological studies has revealed that a diet rich in fruits and vegetables could lower the risk of certain cancers. In this setting, natural polyphenols are potent anticancer bioactive compounds to overcome the non-target specificity, undesirable cytotoxicity and high cost of treatment cancer chemotherapy.The review focuses on diverse classifications of the chemical diversity of dietary polyph ...
DOI:: 10.1016/j.phymed.2021.153554
: https://doi.org/10.1016/j.phymed.2021.153554

32. Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole‐induced polycystic ovary syndrome in rats

Author:: Yanyuan Zhou; Huan Lan; Zhewen Dong; Wenjing Cao; Zhen Zeng; Jia‐Le Song
Source:: Journal of food biochemistry 2021 v.45 no.5 pp. e13723
ISSN:: 0145-8884
Subject:: anti-aging properties; antineoplastic activity; antioxidant activity; blood lipids; blood serum; body weight; cholesterol homeostasis; dietary supplements; females; fibrosis; oxidative stress; polycystic ovary syndrome; proanthocyanidins
Abstract:: ... This study investigated the effects of proanthocyanidins (PCs) on ovarian fibrosis in letrozole‐induced polycystic ovary syndrome (PCOS) in rats. The administration of PCs effectively reduced the body weight (BW) and relative ovarian weight in PCOS rats. ELISA results revealed that PCs significantly reduced the level of serum T, LH, LH/FSH in the PCOS group. In addition, qRT‐PCR results revealed t ...
DOI:: 10.1111/jfbc.13723
: https://doi.org/10.1111/jfbc.13723

33. Effects of Momordica cochinchinensis Aril Extract on Sterilized Low-Fat Milk, Antioxidant and Antiproliferative Activities

Author:: Thitiporn Anunthawan; Santi Phosri; Jirayus Woraratphoka; Rasapirose Somwatcharajit; Panee Terdsaksri; Prangruethai Prangphet
Source:: International Journal of Food Sciences 2022 v.2022 pp. -
ISSN:: 2314-5765
Subject:: Momordica cochinchinensis; alcohols; antineoplastic activity; antioxidant activity; antioxidants; aril; fruit extracts; lipid peroxidation; low fat milk; neoplasm cells; sensory evaluation; shelf life; toxicity
Abstract:: ... The aril extract (0.4% g/mL) of Gac fruit in milk supplement can inhibit cancer cell lines. Moreover, the extract has no toxicity against normal cells. In a sensory test, sterilized low-fat milk supplemented with 0.4% extract did not have different sensory score compared to the control. During the sterilization process, extract was not significantly different from the control. In sterilization (12 ...
DOI:: 10.1155/2022/7934454
: https://doi.org/10.1155/2022/7934454

34. Effects of multi-mode divergent ultrasound pretreatment on the physicochemical and functional properties of polysaccharides from Sagittaria sagittifolia L

Author:: Yuqin Feng; Igbokwe Chidimma Juliet; Chaoting Wen; Yuqing Duan; Jie Zhou; Yuanqing He; Haihui Zhang; Haile Ma
Source:: Food bioscience 2021 v.42 pp. 101145
ISSN:: 2212-4292
Subject:: Sagittaria sagittifolia; antineoplastic activity; antioxidant activity; arabinose; cosmetics; foams; galactose; glucose; mannose; medicine; polysaccharides; rhamnose; solubility; thermal stability; ultrasonics; uronic acids; xylose
Abstract:: ... The aim of this study was to investigate the physicochemical and functional properties of polysaccharides from Sagittaria sagittifolia L. (SSP), extracted by the assistance of multi-mode divergent ultrasound (SSU), with different frequencies (20, 28, 40 kHz) and various combinations (20/28, 20/40, 28/40, 20/28/40 kHz). The results showed that, compared with hot water extraction, multi-mode diverge ...
DOI:: 10.1016/j.fbio.2021.101145
: https://doi.org/10.1016/j.fbio.2021.101145

35. Evaluation of a novel phosphorylated corn straw xylan for enhancement of thermal stability, crystallinity and functional activity

Author:: Shiquan Qian; Yuting Yu; Jing Ma; Enjie Diao; Shijia Ye; Jiamin Gao; Ying Liu; Weicheng Hu
Source:: International journal of food science & technology 2022 v.57 no.1 pp. 481-488
ISSN:: 0950-5423
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; corn straw; crystal structure; food science; hydroxyl radicals; spectral analysis; superoxide anion; technology; temperature; thermal analysis; thermal stability; xylan
Abstract:: ... The present study focussed on a novel phosphorylated corn straw xylans (XYCS‐P) that had excellent thermal stability, crystallinity and functional activity and could be potentially used as functional agents in food products. In this work, the phosphorylated derivative XYCS‐P was successfully prepared, and the chemical characterisation, spectral analysis, thermal analysis, morphology analysis, anti ...
DOI:: 10.1111/ijfs.15428
: https://doi.org/10.1111/ijfs.15428

36. Evaluation of biological activities of Barbarea integrifolia and isolation of a new glucosinolate derivated compound

Author:: Merve Badem; Sıla Ozlem Sener; Seyda Kanbolat; Nuriye Korkmaz; Sermet Yildirmiş; Ufuk Ozgen; Rezzan Aliyazicioglu; Emine Salva; Kübra Kaban; Ali Kandemir; İhsan Calıs
Source:: Zeitschrift für Naturforschung 2021 v.76 no.9-10 pp. 375-382
ISSN:: 1865-7125
Subject:: Barbarea; antineoplastic activity; antioxidant activity; chloroform; choline; chromatography; ethyl acetate; glucosinolates; human cell lines; kaempferol; phenolic acids; rosmarinic acid; toxicity testing; vincristine
Abstract:: ... The aim of the present study is to determine the potent biological activities and carry out isolation studies on Barbarea integrifolia. The antioxidant capacity of the species was evaluated by total phenolic content, FRAP, CUPRAC, and DPPH radical scavenging activity. Anticancer activity studies were performed by MTT assay in MDA-MB-231, MCF-7, Hep3B, PC-3, A549, HCT116, L-929 cell lines. It was o ...
DOI:: 10.1515/znc-2020-0305
: https://doi.org/10.1515/znc-2020-0305

37. Extraction of Zanthoxylum seed protein and identification of its simulated digestion products

Author:: Qingying Luo; Xiaomeng Li; Zhiqing Zhang; Anjun Chen; Shanshan Li; Guanghui Shen; Meiliang Li; Xingyan Liu; Xueqin Yin; Lan Cheng; Xingpan Yang; Chunping Jiang; Jianlong Li; Xiaoyan Hou
Source:: Lebensmittel-Wissenschaft + Technologie 2022 v.161 pp. 113412
ISSN:: 0023-6438
Subject:: Zanthoxylum bungeanum; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; antiviral properties; bioinformatics; byproducts; chemical precipitation; digestion; drugs; in vitro digestion; molecular weight; pH; peptides; temperature
Abstract:: ... Zanthoxylum bungeanum seed is the main by-product of Z. bungeanum processing, which is rich in protein. In this study, Z. bungeanum seed proteins were extracted by alkali-soluble acid precipitation method. The factors affecting the protein yield were ranked as follows: alkali dissolution temperature > extraction time > material–liquid ratio > pH. The optimal process conditions were as follows: ext ...
DOI:: 10.1016/j.lwt.2022.113412
: https://doi.org/10.1016/j.lwt.2022.113412

38. Fruits of Ixora coccinea are a rich source of phytoconstituents, bioactives, exhibit antioxidant activity and cytotoxicity against human prostate carcinoma cells and development of RTS beverage

Author:: Saligrama Viswanath Shreelakshmi; Nagabhushan Chaitrashree; Sandopu Sravan Kumar; Nandini Prasad Shetty; Parvatam Giridhar
Source:: Journal of food processing and preservation 2021 v.45 no.7 pp. e15656
ISSN:: 0145-8892
Subject:: Ixora coccinea; anthocyanins; antineoplastic activity; antioxidant activity; antioxidants; beverages; bioactive compounds; chemical constituents of plants; cytotoxicity; fruit extracts; fruit pulp; high performance liquid chromatography; humans; markets; metabolites; methanol; myricetin; prostatic neoplasms; ready-to-eat foods; shrubs; sinapic acid; solvents; traditional medicine
Abstract:: ... Ixora coccinea is an evergreen shrub bearing fruits that are extensively used in Indian traditional medicine. The phytoconstituents, bioactives, in vitro antioxidants, and anticancer activities of fruits for the development of a ready‐to‐serve beverage were investigated. The phytoconstituent screening revealed the total phenolics, flavonoids, and anthocyanin contents of 128 mg, 20.63 mg, and 30 mg ...
DOI:: 10.1111/jfpp.15656
: https://doi.org/10.1111/jfpp.15656

39. Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma

Author:: M.J. Ramírez-Expósito; M.P. Carrera-González; M.D. Mayas; J.M. Martínez-Martos
Source:: Food research international 2021 v.140 pp. 110023
ISSN:: 0963-9969
Subject:: N-ethyl-N-nitrosourea; animal models; antineoplastic activity; antineoplastic agents; antioxidant activity; blood chemistry; brain; brain neoplasms; carcinogenesis; food research; gender differences; glioma; metabolites; oleuropein; olives; oral administration; oxidative stress; phenolic compounds; rats; virgin olive oil
Abstract:: ... Brain tumorigenesis has been associated not only with oxidative stress, but also with a reduced response of non-enzyme and enzyme antioxidant defense systems. In fact, the imbalance between free-radical production and the efficiency of the antioxidant defense systems triggers the process because the central nervous system (CNS) is very sensitive to free-radical damage. Phenolic compounds, mainly o ...
DOI:: 10.1016/j.foodres.2020.110023
: https://doi.org/10.1016/j.foodres.2020.110023

40. Ginger Extract Loaded into Chitosan Nanoparticles Enhances Cytotoxicity and Reduces Cardiotoxicity of Doxorubicin in Hepatocellular Carcinoma in Mice

Author:: Hend E. Abo Mansour; Maha M. El-Batsh; Nadia S. Badawy; Eman T. Mehanna; Noha M. Mesbah; Dina M. Abo-Elmatty
Source:: Nutrition and cancer 2021 v.73 no.11-12 pp. 2347-2362
ISSN:: 1532-7914
Subject:: albino; antineoplastic activity; antioxidant activity; apoptosis; blood serum; cardiotoxicity; cell viability; chitosan; creatine kinase; cytotoxicity; diethylnitrosamine; doxorubicin; ginger; hepatoma; lactate dehydrogenase; liver; males; malondialdehyde; multiple drug resistance; necrosis; nutrition; therapeutics; vascular endothelial growth factors
Abstract:: ... This study aimed to investigate the impact of ginger extract (GE) loaded into chitosan nanoparticles (CNPs) in enhancing cytotoxicity and reducing cardiotoxicity of doxorubicin (DXN) in hepatocellular carcinoma (HCC) induced mice. DXN and GE were loaded into CNPs and cytotoxicity of loaded and unloaded drugs against HepG2 cells was evaluated. HCC was induced in male albino mice by injection of die ...
DOI:: 10.1080/01635581.2020.1823436
: https://doi.org/10.1080/01635581.2020.1823436

41. Identification of Multi-Potent Protein Subtilisin A from halophilic bacterium Bacillus firmus VE2

Author:: Manikandan P; Jamseel Moopantakath; Madangchanok Imchen; Ranjith Kumavath; P.K. SenthilKumar
Source:: Microbial pathogenesis 2021 v.157 pp. 105007
ISSN:: 0882-4010
Subject:: Bacillus firmus; Candida parapsilosis; Escherichia coli; alanine; antibacterial properties; antimicrobial peptides; antimicrobial proteins; antineoplastic activity; antioxidant activity; aspartic acid; bacteria; computer simulation; cysteine; fungi; genes; halophiles; human cell lines; leucine; lysine; minimum inhibitory concentration; molecular weight; nitric oxide; pH; pathogenesis; polyacrylamide gel electrophoresis; proline; serine; soil; subtilisin; threonine; valine; India
Abstract:: ... Screening of halophiles with antimicrobial activity in saltpan soil samples from Nagapattinam district, Tamil Nadu, revealed isolate VE-2 as the most potent, identified as Bacillus firmus strain VE-2 through 16s rRNA gene sequencing. It had an optimum growth condition (OD 3.1) and antimicrobial protein (AMP) production (450 μg/mL) at 37 °C, pH 8, 25% NaCl, and 36 h incubation. SDS-PAGE analysis of ...
DOI:: 10.1016/j.micpath.2021.105007
: https://doi.org/10.1016/j.micpath.2021.105007

42. Identification of bioactive metabolites from corn silk extracts by a combination of metabolite profiling, univariate statistical analysis and chemometrics

Author:: Natan R.S. da Hora; Lucia F. Santana; Victor Diogenes A. da Silva; Silvia L. Costa; Leonardo Zambotti-Villela; Pio Colepicolo; Caline G. Ferraz; Paulo R. Ribeiro
Source:: Food chemistry 2021 v.365 pp. 130479
ISSN:: 0308-8146
Subject:: anthocyanidins; antineoplastic activity; antioxidant activity; bioactive compounds; chemometrics; corn; flavones; flower extracts; glioma; glycosides; secondary metabolites; statistical analysis; styles (flowers)
Abstract:: ... Corn silk has been widely used as a nutritional and medicinal supplement due to its pharmacological properties, but there is a lack of studies that correlate the extracts’ chemical composition with their biological activities. Herein, we performed the large-scale chemical characterization of corn silk extracts and used chemometrics to correlate the chemical composition with the biological activiti ...
DOI:: 10.1016/j.foodchem.2021.130479
: https://doi.org/10.1016/j.foodchem.2021.130479

43. Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives

Author:: Marta Orlicka-Płocka; Agnieszka Fedoruk-Wyszomirska; Dorota Gurda-Woźna; Paweł Pawelczak; Patrycja Krawczyk; Małgorzata Giel-Pietraszuk; Grzegorz Framski; Tomasz Ostrowski; Eliza Wyszko
Source:: Antioxidants 2021 v.10 no.6 pp. -
ISSN:: 2076-3921
Subject:: antineoplastic activity; antioxidant activity; apoptosis; cell culture; cell growth; drug resistance; glioblastoma; kinetin; lipid peroxidation; mutagens; oxidative stress; reactive oxygen species; therapeutics
Abstract:: ... Recently, small compound-based therapies have provided new insights into the treatment of glioblastoma multiforme (GBM) by inducing oxidative impairment. Kinetin riboside (KR) and newly designed derivatives (8-azaKR, 7-deazaKR) selectively affect the molecular pathways crucial for cell growth by interfering with the redox status of cancer cells. Thus, these compounds might serve as potential alter ...
DOI:: 10.3390/antiox10060950
: https://doi.org/10.3390/antiox10060950

44. Improved water solubility, chemical stability, antioxidant and anticancer activity of resveratrol via nanoencapsulation with pea protein nanofibrils

Author:: Jiang Yi; Qingyu He; Gaofei Peng; Yuting Fan
Source:: Food chemistry 2022 v.377 pp. 131942
ISSN:: 0308-8146
Subject:: antineoplastic activity; antioxidant activity; antioxidants; dietary supplements; fluorescence; food chemistry; hydrophobicity; nanocapsules; nanocarriers; nanofibers; pea protein; protein isolates; resveratrol; water solubility
Abstract:: ... Fabricated pea protein isolate (PPI) nanofibrils were used as nanocarriers to encapsulate, stabilize and deliver resveratrol (RES). PPI nanofibrils possessed a dramatically higher surface hydrophobicity than PPI (native), and PPI nanofibrils exhibited nanoscale widths of 10 nm and average lengths of 1.0 μm. Fluorescence analyses demonstrated PPI nanofibrils had high binding constant with RES. Comp ...
DOI:: 10.1016/j.foodchem.2021.131942
: https://doi.org/10.1016/j.foodchem.2021.131942

45. In Vitro Evaluation of Antioxidant and Anticancer Activity of Lemongrass (Cymbopogon citratus (D.C.) Stapf)

Author:: Daiane Pan; Larissa Machado; Claudia Giuliano Bica; Alencar Kolinski Machado; Jovani Antônio Steffani; Francine Carla Cadoná
Source:: Nutrition and cancer 2022 v.74 no.4 pp. 1474-1488
ISSN:: 1532-7914
Subject:: Cymbopogon citratus; aerobiosis; antineoplastic activity; antioxidant activity; antioxidants; cell viability; cytotoxicity; drug therapy; fluorouracil; kidneys; nutrition; oxidative stress; rotenone; uterine cervical neoplasms
Abstract:: ... Cancer is considered a multifactorial disease and its development could be associated with several factors, for example, rotenone exposition. Unfortunately, many cancers are resistant to chemotherapy, as cervical cancer. Regarding this, lemongrass is a remarkable natural product that presents antioxidant and anticancer activities, which could show therapeutic action against rotenone and cervical c ...
DOI:: 10.1080/01635581.2021.1952456
: https://doi.org/10.1080/01635581.2021.1952456

46. Interactive 360° video to “Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis”

Author:: Carmen Soto-Maldonado; Mauricio Vergara-Castro; John Jara-Quezada; Eduardo Caballero-Valdés; Andrea Müller-Pavez; María Elvira Zúñiga-Hansen; Claudia Altamirano
Source:: Electronic Journal of Biotechnology 2022 v.57 pp. 52-53
ISSN:: 0717-3458
Subject:: Juglans regia; antineoplastic activity; antioxidant activity; apoptosis; biotechnology; carcinogenicity; cell culture; dose response; fibroblasts; hulls; juglone; membrane potential; mitochondrial membrane; synthesis; viability; walnuts
Abstract:: ... Juglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on carcinogenic cell lines. Walnut green husk ethanolic extract was obtained as 169.1 mg juglone/100 g Green Husk and antioxidant activity (ORAC) of 44,920 μmol ...
DOI:: 10.1016/j.ejbt.2022.04.002
: https://doi.org/10.1016/j.ejbt.2022.04.002

47. Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance

Author:: Maside Temiz Bostanci; Ali Savas Bulbul; Ibrahim Seyfettin Celik; Yusuf Ziya Kocabas; Hakan Burhan; Ramazan Bayat; Fatih Sen; Nilofar Zakariae; Roghayeh Esmaeili; Hedayat Jafari; Fatemeh Karimi; Hassan Karimi-Maleh
Source:: Chemosphere 2022 v.288 pp. 132602
ISSN:: 0045-6535
Subject:: Candida parapsilosis; Salvia; agar; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cytotoxicity; human cell lines; inhibitory concentration 50; methanol; minimum inhibitory concentration
Abstract:: ... In this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 bacteria and 2 fungi of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth species were performed by Agar Well Diffusion and Microdilution methods. Salvia species showed sensitivity with a zone diameter of 12–16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the dilution method were us ...
DOI:: 10.1016/j.chemosphere.2021.132602
: https://doi.org/10.1016/j.chemosphere.2021.132602

48. Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

Author:: J. Dharani; S. Ravi
Source:: Chemistry of natural compounds 2022 v.58 no.1 pp. 40-46
ISSN:: 0009-3130
Subject:: Cyanthillium cinereum; DNA replication; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; interphase; sesquiterpenoid lactones
Abstract:: ... Three sesquiterpene lactones has been isolated from Cyanthillium cinereum (L.) H. Rob. by bioactivity guided assay and characterized by spectral methods as compounds 1, 2, and 3. The in vitro anticancer activity was tested against 786-O, MCF-7, and K562 cells by the MTT assay. Compound 1 showed IC₅₀ values of 12.5 and 10.4 μg/mL against 786-O cell line after 48 and 72 h, respectively, and matches ...
DOI:: 10.1007/s10600-022-03593-1
: https://doi.org/10.1007/s10600-022-03593-1

49. LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

Author:: Kouadio Ibrahime Sinan; Uğur Akpulat; Afaf A. Aldahish; Yasemin Celik Altunoglu; Mehmet Cengiz Baloğlu; Dimitrina Zheleva-Dimitrova; Reneta Gevrenova; Devina Lobine; Mohamad Fawzi Mahomoodally; Ouattara Katinan Etienne; Gokhan Zengin; Shafi Mahmud; Raffaele Capasso
Source:: Antioxidants 2021 v.10 no.12 pp. -
ISSN:: 2076-3921
Subject:: Boerhavia diffusa; amylases; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; cell lines; chemical composition; ethyl acetate; flavonoids; glycosides; metabolites; methanol; methylene chloride; neoplasm cells; raw materials; tropical plants
Abstract:: ... Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and biological capabilities of B. diffusa. An UHPLC-HRMS method was used to determine the chemical characterization. The biological ability was examined fo ...
DOI:: 10.3390/antiox10122003
: https://doi.org/10.3390/antiox10122003

50. Microbial chitinases: properties, enhancement and potential applications

Author:: Eman Zakaria Gomaa
Source:: Protoplasma 2021 v.258 no.4 pp. 695-710
ISSN:: 0033-183X
Subject:: anti-inflammatory activity; antifungal properties; antineoplastic activity; antioxidant activity; biopesticides; biopharmaceuticals; chitin; chitinase; chitooligosaccharides; enzyme activity; food biopreservatives; insect pests; insecticidal properties; microbial enzymes; phytophagous insects; plant pathogenic fungi; plant protection
Abstract:: ... Chitinases are a category of hydrolytic enzymes that catalyze chitin and are formed by a wide variety of microorganisms. In nature, microbial chitinases are primarily responsible for chitin decomposition and play a vital role in the balance of carbon and nitrogen ratio in the ecosystem. The physicochemical attributes and the source of chitinase are the main bases that determine their functional ch ...
DOI:: 10.1007/s00709-021-01612-6
: https://doi.org/10.1007/s00709-021-01612-6

51. Multi-Functional Development and Utilization of Rapeseed: Comprehensive Analysis of the Nutritional Value of Rapeseed Sprouts

Author:: Zelin Xiao; Yuying Pan; Chao Wang; Xiongcai Li; Yiqing Lu; Ze Tian; Lieqiong Kuang; Xinfa Wang; Xiaoling Dun; Hanzhong Wang
Source:: Foods 2022 v.11 no.6 pp. -
ISSN:: 2304-8158
Subject:: alpha-tocopherol; amino acid composition; antineoplastic activity; antioxidant activity; beans; crude fiber; crude protein; germination; glucoraphanin; glucose; industry; magnesium; nutritive value; oil crops; rapeseed; selenium; China
Abstract:: ... Rapeseed is the third largest oil crop in the world and the largest oil crop in China. The multi-functional development and utilization of rapeseed is an effective measure for the high-quality development of rapeseed industry in China. In this study, several basic nutrients of eight rapeseed sprouts and five bean sprouts (3–5 varieties each) were determined, including sugar, crude protein, crude f ...
DOI:: 10.3390/foods11060778
: https://doi.org/10.3390/foods11060778

52. Notes on Culturable Endophytic Microorganisms Isolated from 14 Medicinal Plants in Vietnam: A Diversity Analysis to Predict the Host-Microbe Correlations

Author:: Hanh My Tran; Dung Thuy Thi Nguyen; Ngan Thi Mai; Hien Thi Do; Thanh Kim Thi Nguyen; Thao Kim Nu Nguyen; Marc Muller; Huy Quang Nguyen; Hai The Pham
Source:: Current microbiology 2022 v.79 no.5 pp. 140
ISSN:: 0343-8651
Subject:: anti-inflammatory activity; antibacterial properties; antineoplastic activity; antioxidant activity; biodiversity; endophytes; fungi; humans; nucleotide sequences; principal component analysis; secondary metabolites; socioeconomics; Vietnam
Abstract:: ... Endophytes can generate a cornucopia of marvelous bioactive secondary metabolites useful for mankind but their biodiversity and associations with host plants are still elusive. In this study, we explored the culturable endophytic microorganisms associated with 14 medicinal plants that are of high socio-economic value and/or reportedly endemic to northern Vietnam. Specifically, we isolated the endo ...
DOI:: 10.1007/s00284-022-02830-8
: https://doi.org/10.1007/s00284-022-02830-8

53. Novel Bacillus Milk-Clotting Enzyme Produces Diverse Functional Peptides in Semihard Cheese

Author:: Fanqiang Meng; Haizhen Zhao; Fengxia Lu; Xiaomei Bie; Zhaoxin Lu; Yingjian Lu
Source:: Journal of agricultural and food chemistry 2021 v.69 no.9 pp. 2784-2792
ISSN:: 1520-5118
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; antineoplastic activity; antioxidant activity; bioinformatics; calves; cheese industry; chymosin; enzyme inhibition; food chemistry; growth retardation; health services; liver neoplasms; milk clotting; peptides; peptidyl-dipeptidase A; proteolysis; rennet; semisoft cheeses; texture
Abstract:: ... Although rennet is one of the best choices for cheese manufacturing, its production cannot meet the growing demands of the cheese industry. Thus, new milk-clotting enzymes (MCEs) with similar or better properties as/than those of calf chymosin are needed urgently. Here, three MCEs, BY-2, BY-3, and BY-4, were mined by bioinformatic analysis and then expressed in and isolated from Escherichia coli. ...
DOI:: 10.1021/acs.jafc.0c08120
: https://doi.org/10.1021/acs.jafc.0c08120

54. Novel insights on the multi-functional properties of flavonol glucosides from red onion (Allium cepa L) solid waste – In vitro and in silico approach

Author:: Arti Nile; Enkhtaivan Gansukh; Gyun-Seok Park; Doo-Hwan Kim; Shivraj Hariram Nile
Source:: Food chemistry 2021 v.335 pp. 127650
ISSN:: 0308-8146
Subject:: Allium cepa; antineoplastic activity; antioxidant activity; antioxidants; chromatography; computer simulation; enzyme inhibitors; food chemistry; functional foods; glucosides; literature; onions; quercetin; solid wastes; solvents; spectroscopy; therapeutics; xanthine oxidase
Abstract:: ... Flavonol glucosides was extracted from red onion solid waste (ROSW) and multi-functional properties were determined to develop alternative strategy for therapeutic beneficiation and utilisation as functional food. The major flavonol glucosides extracted from ROSW were confirmed as quercetin-3, 4′-O-diglucoside (QDG), quercetin-3-O-glucoside (isoquercetin), quercetin-4′-O-glucoside (spiraeoside), i ...
DOI:: 10.1016/j.foodchem.2020.127650
: https://doi.org/10.1016/j.foodchem.2020.127650

55. Optimized ultrasound-assisted extraction of total polyphenols from Empetrum nigrum and its bioactivities

Author:: Yuan Gao; Shengfang Wang; Shikun Dang; Shulan Han; Cholil Yun; Wenjie Wang; Huimei Wang
Source:: Journal of chromatography 2021 v.1173 pp. 122699
ISSN:: 1570-0232
Subject:: Empetrum nigrum; antibacterial properties; antineoplastic activity; antioxidant activity; apoptosis; cell proliferation; chromatography; ethanol; flow cytometry; free radicals; melanoma; pharmaceutical industry; polyphenols; response surface methodology; temperature; toxicity testing; ultrasonic treatment
Abstract:: ... Optimization of ultrasound-assisted extraction (UAE) of total polyphenols (TPP) from Empetrum nigrum aerial parts was carried out by response surface methodology (RSM). The optimum UAE conditions of extraction time, extraction temperature, ethanol concentration, and solvent-to-material ratio were 21.38 min, 42.32 °C, 61.93% and 53.29:1 mL/g, respectively. Under the optimum conditions, the extracti ...
DOI:: 10.1016/j.jchromb.2021.122699
: https://doi.org/10.1016/j.jchromb.2021.122699

56. Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac)

Author:: Halima Alsamri; Khawlah Athamneh; Gianfranco Pintus; Ali H. Eid; Rabah Iratni
Source:: Antioxidants 2021 v.10 no.1 pp. -
ISSN:: 2076-3921
Subject:: Coriaria; Rhus coriaria; administrative management; antineoplastic activity; antioxidant activity; antioxidants; cardiovascular diseases; condiments; diabetes; diarrhea; drugs; eyes; flavonoids; humans; inflammation; polyphenols; spices; tannins; therapeutics; toxicity; toxicity testing; traditional medicine; Mediterranean region
Abstract:: ... Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various ...
DOI:: 10.3390/antiox10010073
: https://doi.org/10.3390/antiox10010073

57. Phytochemical analysis, in-vitro anti-proliferative, anti-oxidant, anti-diabetic, and anti-obesity activities of Rumex rothschildianus Aarons. extracts

Author:: Nidal Jaradat; Mohammed Hawash; Gada Dass
Source:: BMC complementary medicine and therapies 2021 v.21 no.1 pp. 107
ISSN:: 2662-7671
Subject:: Rumex; acarbose; acetone; alpha-amylase; alternative medicine; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; carboxylic ester hydrolases; colorimetry; cytotoxicity; dioecy; flavonoids; hexane; neoplasm cells; oxidative stress; quantitative analysis; uterine cervical neoplasms; Palestine
Abstract:: ... BACKGROUND: Rumex rothschildianus is the sole member of a unique section of the genus Rumex, in the family Polygonaceae. This species is a very rare small dioecious annual, endemic to Palestine that is traditionally used as food and for the treatment of various diseases. Therefore, the current investigation aimed to screen the chemical constituents, antioxidants, anti-α-amylase, anti-α-glucosidase ...
DOI:: 10.1186/s12906-021-03282-6
: https://doi.org/10.1186/s12906-021-03282-6

58. Phytochemical components, antioxidant and anticancer activity of 18 major medicinal plants in Albaha region, Saudi Arabia

Author:: Abdulrahman Ali Alzandi; Essam Ahmed Taher; Nageeb A. Al-Sagheer; Abdul Wali Al-Khulaidi; Mohamed Azizi; Deyala M. Naguib
Source:: Biocatalysis and agricultural biotechnology 2021 v.34 pp. 102020
ISSN:: 1878-8181
Subject:: Aerva javanica; Dodonaea viscosa; Olea europaea subsp. cuspidata; Solanum incanum; agricultural biotechnology; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; ascorbic acid; biocatalysis; chemical constituents of plants; flavonoids; inhibitory concentration 50; medicinal plants; neoplasm cells; saponins; Saudi Arabia
Abstract:: ... Medicinal plants have a great role in influencing health all over the world. There are few studies for the phytochemical investigations in medicinal plants were conducted in Saudi Arabia especially in Albaha region in south-western Saudi Arabia. Therefore this study focused on the detection of the phytochemical composition of the most dominant eighteen natural medicinal plant varieties found in Al ...
DOI:: 10.1016/j.bcab.2021.102020
: https://doi.org/10.1016/j.bcab.2021.102020

59. Polysaccharide from rubescens: extraction, optimization, characterization and antioxidant activities

Author:: Shuang Cheng; Fei He; Longyang Fu; Yadong Zhang
Source:: RSC advances 2021 v.11 no.31 pp. 18974-18983
ISSN:: 2046-2069
Subject:: X-radiation; absorption; antineoplastic activity; antioxidant activity; arabinose; galactose; glucose; mannose; polysaccharides; research and development; response surface methodology; temperature; xylose
Abstract:: ... In this work, rubescens polysaccharide was extracted and extraction conditions were optimized with the response surface method (RSM). The extracted polysaccharide was structurally elucidated and its antioxidant activity was investigated. The best extraction conditions were as follows: the solvent-solid ratio was 33.33 : 1, the extraction temperature was 87.70 °C and the extraction time was 2.59 h. ...
DOI:: 10.1039/d1ra01365c
: https://doi.org/10.1039/d1ra01365c

60. Preparation and characterization of feruloylated oat β-glucan with antioxidant activity and colon-targeted delivery

Author:: Yun-Cheng Li; Yan Luo; Fan-Bing Meng; Jian Li; Wei-Jun Chen; Da-Yu Liu; Long-Hua Zou; Li Zhou
Source:: Carbohydrate polymers 2022 v.279 pp. 119002
ISSN:: 0144-8617
Subject:: antineoplastic activity; antioxidant activity; antioxidants; chemoprevention; colon; colorectal neoplasms; crystal structure; digestion; ferulic acid; humans; oats; oligosaccharides; therapeutics; thermal stability; water solubility
Abstract:: ... Ferulic acid (FA) is an effective chemopreventive and therapeutic agent for colorectal cancer. However, FA cannot stably reach the colon through human digestive system, and it can be grafted into oligosaccharides to improve its digestion stability. Therefore, in this study, different degrees of substitution of feruloylated oat β-glucan (FA-OβG) were prepared by grafting FA onto water soluble oat β ...
DOI:: 10.1016/j.carbpol.2021.119002
: https://doi.org/10.1016/j.carbpol.2021.119002

61. Quercetin attenuates the cardiotoxicity of doxorubicin–cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple‐negative breast cancer

Author:: Puwei Zhang; Jianing Zhang; Lin Zhao; Shizheng Li; Kun Li
Source:: Phytotherapy research 2022 v.36 no.1 pp. 551-561
ISSN:: 0951-418X
Subject:: adverse effects; antineoplastic activity; antioxidant activity; breast neoplasms; cardiomyocytes; cardiotoxicity; cyclophosphamide; doxorubicin; drug therapy; oxidative stress; phytotherapy; protective effect; quercetin; reactive oxygen species; research
Abstract:: ... Doxorubicin combined with cyclophosphamide (AC) is the most commonly used regimen for triple‐negative breast cancer (TNBC) chemotherapy; however, its clinical application is severely limited by its serious adverse effect on cardiomyocytes. The cardiotoxicity of AC is mainly the result of oxidative stress caused by the imbalance between reactive oxygen species (ROS) and antioxidants, and it also in ...
DOI:: 10.1002/ptr.7342
: https://doi.org/10.1002/ptr.7342

62. Schiff base 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide up-regulates the antioxidant status and inhibits the progression of Ehrlich solid tumor in mice

Author:: Helnan A. Aboseada; Mohamed M. Hassanien; Ibrahim H. El-Sayed; Entsar A. Saad
Source:: Biochemical and biophysical research communications 2021 v.573 pp. 42-47
ISSN:: 0006-291X
Subject:: adults; albino; antineoplastic activity; antioxidant activity; antioxidants; blood; catalase; cisplatin; creatinine; females; glutathione; kidneys; liver; longevity; malondialdehyde; neoplasms; nephrotoxicity; nitric oxide; research; schiff bases; solvents; therapeutics; urea; uric acid
Abstract:: ... Cisplatin is an approved cancer therapeutic drug used to treat many solid tumors but its accumulation in the kidney, which causes nephrotoxicity, limits its clinical use. Therefore, investigators seek new alternatives to cisplatin that may be more effective and/or safer. Thiosemicarbazides are of great significance due to their expected biological activity including anticancer activities. The aim ...
DOI:: 10.1016/j.bbrc.2021.07.102
: https://doi.org/10.1016/j.bbrc.2021.07.102

63. Shahatra (F.parviflora Lam)- a comprehensive review of its ethnopharmacology, phytochemistry and pharmacology

Author:: F.N. Jamaldeen; Ghulamuddin Sofi; M.F.M. Fahim; Mohammed Aleem; E.M.G.K.N. Begum
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114839
ISSN:: 0378-8741
Subject:: Ayurvedic medicine; Internet; anthelmintics; antineoplastic activity; antioxidant activity; antiprotozoal properties; blood; bronchodilators; computer software; cytotoxicity; ethnobotany; glycemic effect; hepatoprotective effect; immunomodulation; mechanism of action; parasympatholytics; pharmacognosy; phytochemicals; temperament; trees; Iraq
Abstract:: ... F.parviflora Lam. is a plant widely used in traditional medicine systems like Unani, Ayurveda, and folk medicines in Iraq and Turkey. It is known as Shahatraj in Arabic, which is derived from Shahatra and called Shajaratuddam. In the ancient Unani system, it is called Shajaratuddam. The term derived from Sajarat means tree, and Dam means blood since it has a potent blood purifier property.This rev ...
DOI:: 10.1016/j.jep.2021.114839
: https://doi.org/10.1016/j.jep.2021.114839

64. Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)

Author:: Nemanja Teslić; Filipa Santos; Filipe Oliveira; Alena Stupar; Milica Pojić; Anamarija Mandić; Branimir Pavlić; Aleksandra Cvetanović Kljakić; Ana Rita C. Duarte; Alexandre Paiva; Aleksandra Mišan
Source:: Antioxidants 2022 v.11 no.2 pp. -
ISSN:: 2076-3921
Subject:: antineoplastic activity; antioxidant activity; ellagic acid; hydrolysis; methanol; polyphenols; raspberries; response surface methodology; temperature
Abstract:: ... Defatted raspberry seeds were used as an alternative source of antioxidants and ellagic acid (EA) extracted using Natural deep eutectic solvents (NADES). In the preliminary study, the best NADES combination (citric acid-betaine) and the most influential variables (temperature, time, and NADES/plant ratio) were selected for the further optimization process. All samples were analyzed in terms of tot ...
DOI:: 10.3390/antiox11020254
: https://doi.org/10.3390/antiox11020254

65. Simultaneous detection of anticancer compounds (Cucurbitacin I, B and E) and some pharmacological properties of Indian Blastania species

Author:: Usmangani Abdul Attar; Savaliram Goga Ghane; Niranjana Sunil Chavan; Panditrao Dattaraya Shiragave
Source:: South African journal of botany 2022 v.147 pp. 871-881
ISSN:: 0254-6299
Subject:: Bacillus cereus; Bacillus subtilis; Cucurbitaceae; Staphylococcus aureus; alpha-amylase; animal pathogens; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; cucurbitacins; diabetes; oxidative stress; principal component analysis
Abstract:: ... Cucurbitacins are the predominant tetracyclic tri-terpenoids found in Cucurbitaceae members and possess several biological properties including anticancer. Therefore, the study was aimed at extracting and estimating three anticancer compounds viz. cucurbitacin I (CUI), cucurbitacin B (CUB) and cucurbitacin E (CUE) from two Cucurbitaceae species [Blastania cerasiformis (Stocks) A. Meeuse and Blasta ...
DOI:: 10.1016/j.sajb.2022.03.019
: https://doi.org/10.1016/j.sajb.2022.03.019

66. Sodium alginate nanofibers loaded Terminalia catappa scaffold regulates intrinsic apoptosis signaling in skin melanoma cancer

Author:: Lakshmanan Muthulakshmi; Selvakani Prabakaran; Vaikundamoorthy Ramalingam; A. Varada Rajulu; Marriappan Rajan; Seeram Ramakrishna; Hongrong Luo
Source:: Process biochemistry 2022 v.118 pp. 92-102
ISSN:: 1359-5113
Subject:: Fourier transform infrared spectroscopy; Terminalia catappa; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cancer therapy; caspase-9; cytotoxicity; medicinal plants; melanoma; mitochondria; nanofibers; polymers; skin (animal); skin neoplasms; sodium alginate
Abstract:: ... Drug delivery by nanofibrous scaffold is a promising approach for treating cancer disease. In this study, bioactive compounds were extracted from the medicinal plant Terminalia catappa and loaded into sodium alginate (SA) polymer to prepare a bioactive electrospun nanofibers. Initially, SA polymeric fibers alone was prepared by electrospinning approach and characterized by FT-IR spectroscopy, XRD ...
DOI:: 10.1016/j.procbio.2022.04.004
: https://doi.org/10.1016/j.procbio.2022.04.004

67. Sour black mulberry (Morus nigra L.) causes cell death by decreasing mutant p53 expression in HT-29 human colon cancer cells

Author:: Yavuz Erden
Source:: Food bioscience 2021 v.42 pp. 101113
ISSN:: 2212-4292
Subject:: DNA damage; Morus nigra; antineoplastic activity; antioxidant activity; cell death; cell viability; colorectal neoplasms; cytotoxicity; flavonoids; humans; mutagens; mutants; neoplasm cells; plant extracts; traditional medicine; Asia; Europe
Abstract:: ... Cancer is an important health problem and obtaining new information about the treatment of this disease is an important gain. Morus nigra L. (black mulberry) is an important medical plant in Asia and Europe and has an important place in food and folk medicine. The present study aimed to determine the anti-cancer effect of sour black mulberry on human colon cancer cell (HT-29). In the current inves ...
DOI:: 10.1016/j.fbio.2021.101113
: https://doi.org/10.1016/j.fbio.2021.101113

68. Synthesis of Nanocapsules Based on Biosynthesized Nickel Nanoparticles and Potato Starch: Antimicrobial, Antioxidant, and Anticancer Activity

Author:: Amr H. Hashem; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Mohamed Hasanin
Source:: Stärke = 2022 v.74 no.1-2 pp. e2100165
ISSN:: 0038-9056
Subject:: Aspergillus niger; Bacillus subtilis; Candida albicans; Cryptococcus neoformans; Escherichia coli; Penicillium chrysogenum; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biopolymers; bioprocessing; biosynthesis; cell lines; inhibitory concentration 50; nanocapsules; nickel; potato starch; thermogravimetry
Abstract:: ... Biogenic fabrication of nanoparticles (NPs) by fungi becomes a promising protocol due to effective and environmentally friendly bioprocess. The capsulation of nanoparticles into biopolymer has received considerable attention owing to improve stability. The nickel nanoparticles (Ni‐NPs) are synthesized using Penicillium chrysogenum and capsulated into potato starch to produce nanocapsules (Ni‐NPs@s ...
DOI:: 10.1002/star.202100165
: https://doi.org/10.1002/star.202100165

69. The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs’ Re-regulation: An in vitro Study on Human Malignant Melanoma Cells

Author:: Dilara Kamer Colak; Unal Egeli; Isil Ezgi Eryilmaz; Onder Aybastier; Hulusi Malyer; Gulsah Cecener; Berrin Tunca
Source:: Nutrition and cancer 2022 v.74 no.1 pp. 211-224
ISSN:: 1532-7914
Subject:: Dittrichia viscosa; antineoplastic activity; antioxidant activity; apoptosis; cell cycle checkpoints; chromatography; drug therapy; fibroblasts; humans; melanoma; methanol; microRNA; nutrition; phenolic compounds; skin neoplasms
Abstract:: ... Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy’s limited effect. In the present study, we evaluated the anticancer potentials of Inula viscosa methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferati ...
DOI:: 10.1080/01635581.2020.1869791
: https://doi.org/10.1080/01635581.2020.1869791

70. The effects of quorum sensing molecule farnesol on the yield and activity of extracellular polysaccharide from Grifola frondosa in liquid fermentation

Author:: Xiao-li Wang; Le-le Zhang; Ni Chen; Jian Li; Cheng-feng Han; Shuai Wang; Li-min Hao; Shi-ru Jia; Pei-pei Han
Source:: International journal of biological macromolecules 2021 v.191 pp. 377-384
ISSN:: 0141-8130
Subject:: Grifola frondosa; antineoplastic activity; antioxidant activity; chemical composition; farnesol; fungi; humans; hydroxyl radicals; liquid state fermentation; liver neoplasms; polysaccharides; uronic acids; uterine cervical neoplasms
Abstract:: ... A strategy by exogenous addition of quorum sensing molecule farnesol to improve the production, antioxidant activity and antitumor activity of extracellular polysaccharide (EPS) of Grifola frondosa by liquid fermentation was proposed in the study. The highest yield of EPS induced by farnesol was 1.25 g/L, which was 150% higher than that of the control. Four polysaccharides including EPS-C-0M, EPS- ...
DOI:: 10.1016/j.ijbiomac.2021.09.088
: https://doi.org/10.1016/j.ijbiomac.2021.09.088

71. Variations in the Anticancer Activity of Free and Bound Phenolics of Finger Millet (Eleusine coracana (L) Gaertn; Variety KMR-301) Seeds

Author:: Mahadevaswamy G. Kuruburu; Venugopal R. Bovilla; Rimshia Naaz; Zonunsiami Leihang; SubbaRao V. Madhunapantula
Source:: Phytomedicine plus 2022 v.2 no.2 pp. 100276
ISSN:: 2667-0313
Subject:: 4',6-diamidino-2-phenylindole; DNA; Eleusine coracana subsp. coracana; acridine orange; amino acids; antineoplastic activity; antioxidant activity; breast neoplasms; breasts; cakes; calcium; cell cycle; cell death; cell lines; cell proliferation; colon; colorectal neoplasms; cytotoxicity; dietary fiber; ethanol; ethidium; flavonoids; fluorescence microscopes; malt; neoplasm cells; porridge; rectum; rice cakes; savory; seeds; Africa; India
Abstract:: ... Finger millet (FM, Eleusine coracana (L) Gaertn; also known as “ragi” in Kannada language) is one of the widely used millets especially in south India and parts of Africa. FM is consumed in various forms that include porridge, mudde (ball), dosa (a pan cake), idly (a savory rice cake) and biscuits/cookies. FM is also used in the form of malted drink known as “malted ragi or ragi malt”. FM is a ric ...
DOI:: 10.1016/j.phyplu.2022.100276
: https://doi.org/10.1016/j.phyplu.2022.100276

72. A Comparative Antibacterial, Antioxidant, and Antineoplastic Potential of Rauwolfia serpentina (L.) Leaf Extract with Its Biologically Synthesized Gold Nanoparticles (R-AuNPs)

Author:: Mohammad Y. Alshahrani; Zeeshan Rafi; Nadiyah M. Alabdallah; Ambreen Shoaib; Irfan Ahmad; Mohammed Asiri; Gaffar Sarwar Zaman; Shadma Wahab; Mohd Saeed; Salman Khan
Source:: Plants 2021 v.10 no.11 pp. -
ISSN:: 2223-7747
Subject:: Bacillus subtilis; Escherichia coli; Gram-negative bacteria; Proteus vulgaris; Rauvolfia serpentina; Staphylococcus aureus; Streptococcus pyogenes; amoxicillin; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; cell lines; encapsulation; humans; inhibitory concentration 50; leaf extracts; medicinal plants; nanogold; transmission electron microscopy; ultraviolet-visible spectroscopy; uterine cervical neoplasms; zeta potential
Abstract:: ... Rauwolfia serpentina (R. serpentina), belonging to the family Apocynaceae, is a renowned medicinal herb for its different pharmacological activities such as antibacterial, antifungal, anti-inflammatory, and antiproliferative characteristics. This study has done a comparative assessment of the antibacterial, antioxidant, and anti-cancer activity of R. serpentina aqueous leaf extract (RSALE) with en ...
DOI:: 10.3390/plants10112278
: https://doi.org/10.3390/plants10112278

73. A New Anticancer Bisflavan-3-Ol from Boerhavia elegans

Author:: Najeeb Ur Rehman; Hidayat Hussain; Husain Yar Khan; Ghulam Abbas; Hidayatullah; Ahmed Al-Harrasi
Source:: Chemistry of natural compounds 2020 v.56 no.2 pp. 235-238
ISSN:: 0009-3130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Boerhavia elegans; acetylcholinesterase; alpha-glucosidase; antineoplastic activity; antioxidant activity; breast neoplasms; carbon; cell viability; electrospray ionization mass spectrometry; enzyme inhibition; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; urease; xanthine oxidase
Abstract:: ... A new a bisflavan-3-ol, boerhavianane (1), was isolated from Boerhavia elegans L. The structure of the flavanol dimer was elucidated by detailed spectroscopic analysis including ¹H, ¹³C NMR, COSY, HMQC, HMBC, and ESI-MS. Boerhavianane (1) was evaluated for its anticancer activity and demonstrated a significant reduction in the viability of breast cancer cells in a concentration-dependent manner wi ...
DOI:: 10.1007/s10600-020-02995-3
: https://doi.org/10.1007/s10600-020-02995-3

74. A caryophyllene oxide and other potential anticholinesterase and anticancer agent in Salvia verticillata subsp. amasiaca (Freyn & Bornm.) Bornm. (Lamiaceae)

Author:: Songul Karakaya; Serdar Volkan Yilmaz; Özlem Özdemir; Mehmet Koca; Nur Münevver Pınar; Betül Demirci; Kadir Yıldırım; Oksana Sytar; Hasan Turkez; K. Hüsnü Can Baser
Source:: Journal of essential oil research 2020 v.32 no.6 pp. 512-525
ISSN:: 2163-8152
Subject:: Salvia; acetone; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell viability; cholinesterase; essential oils; monoterpenoids; research; spathulenol; trichomes
Abstract:: ... In vitro cholinesterase inhibition, antioxidant and anticancer potentials of the essential oils and extracts of flowers and aerial parts of Salvia verticillata subsp. amasiaca have been studied. The GC-MS and GC-FID analyses found that major components of the essential oils were caryophyllene oxide, caryophylladienol II, spathulenol, hexahydrofarnesyl acetone and phytol. Oxygenated sesquiterpenes ...
DOI:: 10.1080/10412905.2020.1813212
: https://doi.org/10.1080/10412905.2020.1813212

75. A thermophilic C-phycocyanin with unprecedented biophysical and biochemical properties

Author:: Giarita Ferraro; Paola Imbimbo; Angela Marseglia; Anna Illiano; Carolina Fontanarosa; Angela Amoresano; Giuseppe Olivieri; Antonino Pollio; Daria Maria Monti; Antonello Merlino
Source:: International journal of biological macromolecules 2020 v.150 pp. 38-51
ISSN:: 0141-8130
Subject:: Cyanobacteria; Rhodophyta; antineoplastic activity; antineoplastic agents; antioxidant activity; biomedical research; circular dichroism spectroscopy; cosmetics; cytotoxicity; dietary supplements; energy transfer; fluorescence; fluorescence emission spectroscopy; food industry; hydrogen peroxide; mass spectrometry; neoplasm cells; neoplasms; oxidants; pH; pasteurization; pharmaceutical industry; pigments; polyacrylamide gel electrophoresis; proteins; temperature; ultraviolet-visible spectroscopy
Abstract:: ... C-phycoyanins are abundant light-harvesting pigments which have an important role in the energy transfer cascade of photosystems in prokaryotic cyanobacteria and eukaryotic red algae. These proteins have important biotechnological applications, since they can be used in food, cosmetics, nutraceutical, pharmaceutical industries and in biomedical research. Here, C-phycocyanin from the extremophilic ...
DOI:: 10.1016/j.ijbiomac.2020.02.045
: https://doi.org/10.1016/j.ijbiomac.2020.02.045

76. A unique phenolic extraction method from olive oil macerate of Hypericum perforatum using DMSO: Assessment of in vitro anticancer activity, LC-MS/MS profile, total phenolic content and antioxidant capacity

Author:: Erdal Eroglu; Seyda Nur Girgin
Source:: South African journal of botany 2021 v.139 pp. 6-11
ISSN:: 0254-6299
Subject:: Hypericum perforatum; antidepressants; antineoplastic activity; antioxidant activity; antioxidants; cell proliferation; gallic acid; humans; olive oil; prostatic neoplasms; quercetin
Abstract:: ... Hypericum perforatum, one of the most prominent traditional medicinal plants widely consumed worldwide due to its antioxidant, antimicrobial, antiviral, antidepressant, anticancer effects, are also utilized in external applications for the treatment of wounds and burns. H. perforatum has been attracting the scientists’ interest with its rich phenolic content and various biological activities over ...
DOI:: 10.1016/j.sajb.2021.01.015
: https://doi.org/10.1016/j.sajb.2021.01.015

77. Agrobacterium rhizogenes mediated transformation of Ficus carica L. for the efficient production of secondary metabolites

Author:: Shahla Amani; Mehdi Mohebodini; Shahram Khademvatan; Morad Jafari
Source:: Journal of the science of food and agriculture 2020 v.100 no.5 pp. 2185-2197
ISSN:: 0022-5142
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Ficus carica; Rhizobium rhizogenes; antineoplastic activity; antioxidant activity; antioxidants; apigenin; caffeic acid; chlorogenic acid; cinnamic acid; essential oils; gallic acid; gas chromatography-mass spectrometry; leaves; methyl jasmonate; monoterpenoids; phenol; quercetin; rosmarinic acid; rutin; secondary metabolites; shoots; thymol
Abstract:: ... BACKGROUND: Ficus carica L., an ancient source of food and medicines, is rich in valuable nutritional and secondary compounds with antioxidant, antimicrobial, and anticancer effects. The present study is the first attempt to examine hairy root (HR) induction of F. carica (Sabz and Siah) by inoculating the 3‐week‐old shoots and leaves with different strains of Agrobacterium rhizogenes and also to i ...
DOI:: 10.1002/jsfa.10243
: https://doi.org/10.1002/jsfa.10243

78. Alginate degrading enzymes: an updated comprehensive review of the structure, catalytic mechanism, modification method and applications of alginate lyases

Author:: Qian Li; Ling Zheng; Zilong Guo; Tiancheng Tang; Benwei Zhu
Source:: Critical reviews in biotechnology 2021 v.41 no.6 pp. 953-968
ISSN:: 1549-7801
Subject:: alginate lyase; alginates; antimicrobial properties; antineoplastic activity; antioxidant activity; biotechnology; carbon; oligosaccharides
Abstract:: ... Alginate, a kind of linear acidic polysaccharide, consists of α-L-guluronate (G) and β-D-mannuronate (M). Both alginate and its degradation products (alginate oligosaccharides) possess abundant biological activities such as antioxidant activity, antitumor activity, and antimicrobial activity. Therefore, alginate and alginate oligosaccharides have great value in food, pharmaceutical, and agricultur ...
DOI:: 10.1080/07388551.2021.1898330
: https://doi.org/10.1080/07388551.2021.1898330

79. Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Author:: Deepika Singh; Deepak Chaudhary; Vikas Kumar; Amita Verma
Source:: Toxicology reports 2021 v.8 pp. 636-645
ISSN:: 2214-7500
Subject:: Carissa carandas; animal models; antineoplastic activity; antioxidant activity; antioxidants; blood serum; carcinogenesis; cytokines; diethylnitrosamine; dose response; histopathology; inflammation; instrumentation; kidney neoplasms; nanosilver; nephroprotective effect; nephrotoxicity; oxidative stress; silver; therapeutics; toxicology
Abstract:: ... Inflammation and oxidative stress are the main factors ascribed with interruption in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well recognized in animals and humans. Administration of the smallest quantities of diethylnitrosamine or dimethylnitrosamine either orally or parenterally results into renal damage. Therapeutic effects of phytofabricated sil ...
DOI:: 10.1016/j.toxrep.2021.03.014
: https://doi.org/10.1016/j.toxrep.2021.03.014

80. Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxidant Compounds for Colon Cancer Therapy: A Preliminary In Vitro Study

Author:: Laura Cabeza; Mercedes Peña; Rosario Martínez; Cristina Mesas; Milagros Galisteo; Gloria Perazzoli; Jose Prados; Jesús M. Porres; Consolación Melguizo
Source:: Biology 2021 v.10 no.2 pp. -
ISSN:: 2079-7737
Subject:: Symbiodinium; antineoplastic activity; antioxidant activity; antioxidants; cancer therapy; cell death; colorectal neoplasms; digestion; fatty acid composition; invertebrates; microalgae; polyunsaturated fatty acids; proximate composition; symbionts
Abstract:: ... Recently, invertebrate marine species have been investigated for the presence of natural products with antitumor activity. We analyzed the invertebrate Anemonia sulcata with (W) and without (W/O) the presence of its microalgal symbiont Symbiodinium as a source of bioactive compounds that may be applied in the therapy and/or prevention of colorectal cancer (CRC). Animals were mechanically homogeniz ...
DOI:: 10.3390/biology10020134
: https://doi.org/10.3390/biology10020134

81. Anti- and pro-oxidant potential of lettuce (Lactuca sativa L.) biofortified with iodine by KIO₃, 5-iodo- and 3,5-diiodosalicylic acid in human gastrointestinal cancer cell lines

Author:: Olga Sularz; Aneta Koronowicz; Sylwester Smoleń; Iwona Kowalska; Łukasz Skoczylas; Marta Liszka-Skoczylas; Małgorzata Tabaszewska; Joanna Pitala
Source:: RSC advances 2021 v.11 no.44 pp. 27547-27560
ISSN:: 2046-2069
Subject:: Lactuca sativa; antineoplastic activity; antioxidant activity; biofortification; cell death; gastrointestinal neoplasms; humans; iodine; lettuce; neoplasm cells; phytochemicals; polyphenols; potassium; reactive oxygen species; water solubility
Abstract:: ... Vegetables are particularly rich sources of micronutrients and phytochemicals such as polyphenols and vitamins. These plant-derived bioactive compounds provide antitumor and antioxidant properties due to their capacity to interact with reactive oxygen species (ROS). The objective of this study was to determine the effect of iodine biofortification (potassium iodate/KIO₃/, 5-iodosalicylic acid/5-IS ...
DOI:: 10.1039/d1ra04679a
: https://doi.org/10.1039/d1ra04679a

82. Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells

Author:: Sajida; Ashwini Prabhu
Source:: Phytomedicine 2021 v.90 pp. 153639
ISSN:: 0944-7113
Subject:: DNA damage; Withania somnifera; adenocarcinoma; angiogenesis; antineoplastic activity; antioxidant activity; apoptosis; autophagy; cell movement; comet assay; cytotoxicity; lungs; metalloproteinases; phytochemicals; secondary metabolites
Abstract:: ... Withania somnifera belongs to the family Solanaceae, known as Queen of medicinal plants for its enormous use in the medicinal field. Traditionally ashwagandha is used to treat several neurological disorders. This study evaluates the cytotoxic, apoptotic, antiangiogenic and matrix metalloproteinase (MMP) inhibitory activity of W. somnifera on lung adenocarcinoma.Aqueous and ethanolic extracts were ...
DOI:: 10.1016/j.phymed.2021.153639
: https://doi.org/10.1016/j.phymed.2021.153639

83. Anti-proliferative phytoconstituents from Striga angustifolia (D. Don) C.J. Saldanha – An in vitro and in silico approach

Author:: Kannan Raja; Subramaniam Selvakumar; Rajan Rakkiyappan; Kumarasamy Pradeepa Veerakumari; Krishnan Vasanth
Source:: Phytomedicine plus 2021 v.1 no.3 pp. 100062
ISSN:: 2667-0313
Subject:: Striga; antineoplastic activity; antioxidant activity; chemical composition; chemical constituents of plants; computer simulation; ethyl acetate; metabolites; Africa
Abstract:: ... : Striga angustifolia (D.Don) C.J. Saldanha, belonging to the Orabanchaceae, is indicated to have notable beneficial properties in the traditional medicinal system of Africa. It is said that it aids in the cure of several diseases. Therefore, we aimed to characterize the chemical composition of the plant by analyzing the volatile compounds through GC-MS. The screened compounds were then tested for ...
DOI:: 10.1016/j.phyplu.2021.100062
: https://doi.org/10.1016/j.phyplu.2021.100062

84. Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials

Author:: Alessandro Allegra; Alessandro Tonacci; Giovanni Pioggia; Caterina Musolino; Sebastiano Gangemi
Source:: Nutrients 2020 v.12 no.6 pp. -
ISSN:: 2072-6643
Subject:: Rosmarinus officinalis; antineoplastic activity; antioxidant activity; drug therapy; epigenetics; immune response; rosemary
Abstract:: ... Alternative treatments for neoplastic diseases with new drugs are necessary because the clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural substances of plant origin have been demonstrated to be successful in the prevention and treatment of numerous tumors. Rosmarinus officinalis L. is a herb that is cultivated in diverse areas of the world. There is inc ...
DOI:: 10.3390/nu12061739
: https://doi.org/10.3390/nu12061739

85. Anticancer Effect in Human Glioblastoma and Antioxidant Activity of Petroselinum crispum L. Methanol Extract

Author:: Nadhem Aissani; Ferdaous Albouchi; Hichem Sebai
Source:: Nutrition and cancer 2021 v.73 no.11-12 pp. 2605-2613
ISSN:: 1532-7914
Subject:: Petroselinum crispum; adhesion; antineoplastic activity; antioxidant activity; cell adhesion; chelation; chemical constituents of plants; fibrinogen; fibronectins; gallic acid; glioblastoma; humans; methanol; nutrition; parsley; phenol; protocatechuic acid; quinic acid; traditional medicine
Abstract:: ... Parsley (Petroselinum crispum L.) has been used as food, spices and in folkloric medicine. Several scientific researches have been focalized on anti-inflammatory, anti-proliferative, antioxidant and other pharmacological activities of parsley. The aim of the present study was to evaluate the phytochemical composition, antioxidant and anticancer activity of P. crispum L aqueous and methanol extract ...
DOI:: 10.1080/01635581.2020.1842894
: https://doi.org/10.1080/01635581.2020.1842894

86. Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Author:: Nikoleta Stoyanova; Mariya Spasova; Nevena Manolova; Iliya Rashkov; Ani Georgieva; Reneta Toshkova
Source:: Antioxidants 2020 v.9 no.3 pp. -
ISSN:: 2076-3921
Subject:: 2,2-diphenyl-1-picrylhydrazyl; X-ray diffraction; antineoplastic activity; antioxidant activity; bioactive compounds; cell lines; cellulose; cellulose acetate; contact angle; cytotoxicity; differential scanning calorimetry; free radical scavengers; hydrophilicity; in vitro studies; infrared spectroscopy; melanoma; neoplasm cells; polyethylene glycol; quercetin; scanning electron microscopy; ultraviolet-visible spectroscopy
Abstract:: ... The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several methods including scanning electron microscopy (SEM), IR spectroscopy, X-ray diffraction analysis (XRD), water contact angle measurements, differential scanning calorimetry (DSC), and UV-VIS spect ...
DOI:: 10.3390/antiox9030232
: https://doi.org/10.3390/antiox9030232

87. Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium

Author:: Zhuo Wang; Hongling Wang; Zongli Kang; You Wu; Yao Xing; Yuhong Yang
Source:: Archives of microbiology 2020 v.202 no.7 pp. 1677-1685
ISSN:: 0302-8933
Subject:: Morchella; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; fermentation; high performance liquid chromatography; mycelium; neoplasm cells; triterpenoids
Abstract:: ... Triterpenoid compounds are important bioactivity materials. Morchella is an abundant medicinal fungi found worldwide. In this study, we optimised the isolation and purification of triterpenoid compounds from Morchella mycelium fermentation. The results showed that the triterpenoid compounds yield was 35.22 mg/g, and we also identified two triterpenoid compounds using high-performance liquid chroma ...
DOI:: 10.1007/s00203-020-01876-1
: https://doi.org/10.1007/s00203-020-01876-1

88. Antioxidant and antibacterial activities of Artemisia absinthium and Citrus paradisi extracts repress viability of aggressive liver cancer cell line [Erratum: April 2022, v.49(4); p.3367]

Author:: Muhammad Ali; Rida Iqbal; Muhammad Safdar; Sehrish Murtaza; Ghulam Mustafa; Muhammad Sajjad; Shazia Anwer Bukhari; Tayyaba Huma
Source:: Molecular biology reports 2021 v.48 no.12 pp. 7703-7710
ISSN:: 0301-4851
Subject:: Artemisia absinthium; Citrus paradisi; Escherichia coli; Klebsiella pneumoniae; Salmonella enterica; Staphylococcus aureus; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; disk diffusion antimicrobial test; flavonoids; liver; liver neoplasms; molecular biology; neoplasm cells; viability
Abstract:: ... BACKGROUND: Numerous reports show that herbal medicines can be utilized in the treatment of different liver disorders. In this study, antioxidant, antibacterial, and anticancer activities of individual as well as combined 80% ethanolic extracts of Artemisia absinthium leaves and Citrus paradisi peels were investigated. METHODS AND RESULTS: Values of total phenolic contents (TPC), total flavonoid c ...
DOI:: 10.1007/s11033-021-06777-0
: https://doi.org/10.1007/s11033-021-06777-0

89. Antioxidant and antitumoral activities of isolated macamide and macaene fractions from Lepidium meyenii (Maca)

Author:: Ling Fu; Jinchao Wei; Yumei Gao; Rui Chen
Source:: Talanta 2021 v.221 pp. 121635
ISSN:: 0039-9140
Subject:: Lepidium meyenii; adverse effects; amides; antineoplastic activity; antioxidant activity; breast neoplasms; cancer therapy; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; drugs; free radical scavengers; leukemia; liver neoplasms; lung neoplasms; neoplasm cells; paper
Abstract:: ... In this paper, a UPLC-ESI-MS was established to analyze macamide and macaene fractions from Lepidium meyenii (Maca). The antioxidant activity of Maca crude extract (MCE), total macamides (TMM) and total macaenes (TME) was evaluated by DPPH radical scavenging, ABTS radical scavenging and reducing power. The ability of MCE, TMM and TME against multiple cancer cell lines (leukemia HL-60, lung cancer ...
DOI:: 10.1016/j.talanta.2020.121635
: https://doi.org/10.1016/j.talanta.2020.121635

90. Antioxidant profile at the different stages of craft beers production: the role of phenolic compounds

Author:: Priscila Aparecida Horn; Natalia Bagattoli Pedron; Lucas Henrique Junges; Andrey Martinez Rebelo; Hercílio Higino da Silva Filho; Ana Lúcia Bertarello Zeni
Source:: European food research & technology 2021 v.247 no.2 pp. 439-452
ISSN:: 1438-2377
Subject:: adenocarcinoma; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; beers; biobased products; catechin; cell lines; cell viability; colon; cytotoxicity; fibroblasts; food research; human health; neoplasm cells; spent grains; yeasts
Abstract:: ... The antioxidant composition from four samples, brewer’s spent grain (BSG), brewer’s spent yeast (BRY), a part of the process (POP—after hop addition), and craft beer (CRB) from five popular craft beers were evaluated. The total phenolics, flavonoids, tannins, and ascorbic acid, as well as the antioxidant capacity, were determined. Furthermore, phenolics content was determined by LC–MS/MS technique ...
DOI:: 10.1007/s00217-020-03637-2
: https://doi.org/10.1007/s00217-020-03637-2

91. Antitumor Potential of Lippia citriodora Essential Oil in Breast Tumor-Bearing Mice

Author:: Katerina Spyridopoulou; Tamara Aravidou; Evangeli Lampri; Eleni Effraimidou; Aglaia Pappa; Katerina Chlichlia
Source:: Antioxidants 2021 v.10 no.6 pp. -
ISSN:: 2076-3921
Subject:: Aloysia citrodora; antineoplastic activity; antioxidant activity; apoptosis; asthma; breast neoplasms; breasts; caspase-3; cold; dietary supplements; essential oils; gastrointestinal system; mice; models; oils; oral administration; pro-apoptotic proteins; protein synthesis; tea; traditional medicine
Abstract:: ... Lippia citriodora is a flowering plant cultivated for its lemon-scented leaves and used in folk medicine for the preparation of tea for the alleviation of symptoms of gastrointestinal disorders, cold, and asthma. The oil extracted from the plant leaves was shown to possess antioxidant potential and to exert antiproliferative activity against breast cancer. The aim of this study was to further inve ...
DOI:: 10.3390/antiox10060875
: https://doi.org/10.3390/antiox10060875

92. Betacyanins functionalized selenium nanoparticles inhibit HepG2 cells growth via mitochondria-mediated pathway

Author:: Xiang-Yi Tang; Shu-Juan Yu; Xiao-Ming Guo; He Li; Ming-Shun Chen; Tao Zhang; Cai-Yu Lei; Zhen-Gang Zhao; He-Cheng Meng
Source:: Journal of functional foods 2021 v.78 pp. 104359
ISSN:: 1756-4646
Subject:: antineoplastic activity; antioxidant activity; apoptosis; betacyanins; bioactive compounds; bioavailability; cancer therapy; caspases; drug therapy; functional foods; hepatoma; human cell lines; nanoparticles; neoplasm cells; selenium; toxicity
Abstract:: ... Over the past few years, selenium nanoparticles (SeNPs)-mediated chemotherapy has aroused extensive attention for its low toxicity and high anti-tumor properties. However, the stability and anti-tumor properties of SeNPs require further improvement. In this study, betacyanin (Bc), a natural bioactive compound, was designed to decorate SeNPs with substantial anticancer efficacy. As revealed from th ...
DOI:: 10.1016/j.jff.2021.104359
: https://doi.org/10.1016/j.jff.2021.104359

93. Biochemical and Molecular Investigation of In Vitro Antioxidant and Anticancer Activity Spectrum of Crude Extracts of Willow Leaves Salix safsaf

Author:: Mourad A. M. Aboul-Soud; Abdelkader E. Ashour; Jonathan K. Challis; Atallah F. Ahmed; Ashok Kumar; Amr Nassrallah; Tariq A. Alahmari; Quaiser Saquib; Maqsood A. Siddiqui; Yazeed Al-Sheikh; Hany A. El-Shemy; Ahmed M. Aboul-Enein; Khalid M. Alghamdi; Paul D. Jones; John P. Giesy
Source:: Plants 2020 v.9 no.10 pp. -
ISSN:: 2223-7747
Subject:: Salix; antineoplastic activity; antioxidant activity; apoptosis; caspase-3; chloroform; cytotoxicity; epithelium; ethyl acetate; flavonoids; flow cytometry; fluorescence; gene expression regulation; human cell lines; humans; hybrids; hydrogen peroxide; immunoblotting; leaves; mass spectrometry; messenger RNA; monitoring; oxidation; oxidative stress; plant extracts; pro-apoptotic proteins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; solvents; staining; toxicity testing; ultra-performance liquid chromatography
Abstract:: ... Organic fractions and extracts of willow (Salix safsaf) leaves, produced by sequential solvent extraction as well as infusion and decoction, exhibited anticancer potencies in four cancerous cell lines, including breast (MCF-7), colorectal (HCT-116), cervical (HeLa) and liver (HepG2). Results of the MTT assay revealed that chloroform (CHCl₃) and ethyl acetate (EtOAc)-soluble fractions exhibited spe ...
DOI:: 10.3390/plants9101295
: https://doi.org/10.3390/plants9101295

94. Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer

Author:: Ahmad M. Eid; Mohammed Hawash
Source:: BMC complementary medicine and therapies 2021 v.21 no.1 pp. 159
ISSN:: 2662-7671
Subject:: acarbose; alpha-amylase; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; biological assessment; cytotoxicity; diabetes; droplets; nanocarriers; neoplasm cells; oils; oxidative stress; safrole; zeta potential
Abstract:: ... BACKGROUND: Safrole is a natural compound extracted from various plants, and has shown various biological activities. The current study aimed to investigate the antioxidant, antidiabetic, antimicrobial, and anticancer activity of safrole oil and to study the influence of safrole nanoemulgel on these activities. METHODS: The antioxidant and antidiabetic in-vitro assays were conducted using standard ...
DOI:: 10.1186/s12906-021-03324-z
: https://doi.org/10.1186/s12906-021-03324-z

95. Biomedical Applications of Mycosynthesized Selenium Nanoparticles Using Penicillium expansum ATTC 36200

Author:: Amr Hosny Hashem; Ahmed Mohamed Aly Khalil; Ahmed M. Reyad; Salem S. Salem
Source:: Biological trace element research 2021 v.199 no.10 pp. 3998-4008
ISSN:: 0163-4984
Subject:: Aspergillus fumigatus; Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Penicillium expansum; Pseudomonas aeruginosa; Staphylococcus aureus; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; biosynthesis; cell lines; humans; research; selenium
Abstract:: ... In this study, green and eco-friendly biosynthesis of selenium nanoparticles (Se-NPs) were performed using Penicillium expansum ATTC 36200 for multiple biomedical applications. Mycosynthesized Se-NPs were completely characterized using UV, FT-IR, XRD, SEM, and TEM techniques. Se-NPs biosynthesized by P. expansum was characterized as a spherical shape with average size 4 to 12.7 nm. Moreover, Se-NP ...
DOI:: 10.1007/s12011-020-02506-z
: https://doi.org/10.1007/s12011-020-02506-z

96. Cancer Chemopreventive Properties of Sulfated Enterolobium cyclocarpum Extract

Author:: Amira M. Gamal-Eldeen; Hassan Amer; Amani A Alrehaili; Ahmed Saleh; Abd El-Rahman Al Ghamdi; Nahed M Hawsawi; Asma Salman; Bassem M. Raafat
Source:: Nutrition and cancer 2021 v.73 no.5 pp. 856-868
ISSN:: 1532-7914
Subject:: Enterolobium cyclocarpum; antineoplastic activity; antioxidant activity; carcinogens; carcinoma; chemoprevention; cytotoxicity; diethylnitrosamine; fluorescein; food plants; glutathione transferase; health foods; humans; liver neoplasms; macrophages; metabolism; models; necrosis; nitric oxide; nutrition; phagocytosis; polysaccharides
Abstract:: ... Enterolobium cyclocarpum (EC) is an edible plant and a gum source for food industries. Its sulfated polysaccharide extract (SEC) was examined for cancer chemopreventive properties to estimate its anti-tumor activity. The modulation of carcinogen metabolism and the antioxidant activity revealed that SEC is a potent tumor anti-initiator since it inhibited cytochrome P450-1A (CYP1A) and induced carci ...
DOI:: 10.1080/01635581.2020.1773512
: https://doi.org/10.1080/01635581.2020.1773512

97. Chemical Profile, Antioxidant, Antimicrobial, and Anticancer Activities of the Water-Ethanol Extract of Pulicaria undulata Growing in the Oasis of Central Saudi Arabian Desert

Author:: Hamdoon A. Mohammed; Mohsen S. Al-Omar; Riaz A. Khan; Salman A. A. Mohammed; Kamal A. Qureshi; Manal M. Abbas; Osamah Al Rugaie; Essam Abd-Elmoniem; Adel M. Ahmad; Yasser I. Kandil
Source:: Plants 2021 v.10 no.9 pp. -
ISSN:: 2223-7747
Subject:: Pulicaria undulata; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; breast neoplasms; copper; coumarins; cytotoxicity; fibroblasts; free radicals; gallic acid; halophytes; humans; minimum inhibitory concentration; necrosis; neoplasm cells; oases; quantitative analysis; quercetin; triterpenoids; zinc; Saudi Arabia
Abstract:: ... Pulicaria undulata (L.) C. A. Mey has multiple uses as part of the traditional medicament, and several biological activities of the plant have been corroborated in the scientific literature. The current work evaluates the phytochemical constituents and biological properties of the water-ethanol extract of the P. undulata growing in Qassim, the central arid regions of the Kingdom of Saudi Arabia. Q ...
DOI:: 10.3390/plants10091811
: https://doi.org/10.3390/plants10091811

98. Comparative analysis of antioxidant and antiproliferative activities of crude and purified flavonoid enriched fractions of pods/seeds of two desert legumes Prosopis cineraria and Cyamopsis tetragonoloba

Author:: Vidushi Asati; Abhilasha Srivastava; Sudeshna Mukherjee; Pankaj Kumar Sharma
Source:: Heliyon 2021 v.7 no.6 pp. e07304
ISSN:: 2405-8440
Subject:: Cyamopsis tetragonoloba; Prosopis cineraria; amberlite; antineoplastic activity; antioxidant activity; antioxidants; isoflavonoids; purification methods; semiarid zones; thin layer chromatography; India
Abstract:: ... Cyamopsis tetragonoloba and Prosopis cineraria are two legumes of the semi-arid region of Indian subcontinent which are unexplored with respect to their medicinal potential. Moreover, there is considerable lack in the comparative analysis of the biological properties of crude and enriched fractions obtained from the pods and seeds. Therefore, this study aims in investigating the effect of purifica ...
DOI:: 10.1016/j.heliyon.2021.e07304
: https://doi.org/10.1016/j.heliyon.2021.e07304

99. Comparative study of young shoots and the mature red headed cabbage as antioxidant food resources with antiproliferative effect on prostate cancer cells

Author:: Mariola Drozdowska; Teresa Leszczyńska; Aneta Koronowicz; Ewelina Piasna-Słupecka; Kinga Dziadek
Source:: RSC advances 2020 v.10 no.70 pp. 43021-43034
ISSN:: 2046-2069
Subject:: antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; cabbage; carotenoids; cell lines; comparative study; diet-related diseases; flavonoids; food plants; ingredients; juices; knowledge; neoplasm cells; phenolic acids; polyphenols; prostatic neoplasms; sampling; shoots
Abstract:: ... The increasing knowledge on health benefit properties of plant origin food ingredients supports recommendations for the use of edible plants in the prevention of diet related diseases, including cancer. The beneficial effects of young shoots of red cabbage can be attributed to their mixture of phytochemicals possessing antioxidant and potential anticancer activity. The objective of this study was ...
DOI:: 10.1039/d0ra07861a
: https://doi.org/10.1039/d0ra07861a

100. Cytotoxic activity of Indigofera aspalathoides (Vahl.) extracts in cervical cancer (HeLa) cells: Ascorbic acid adjuvant treatment enhances the activity

Author:: Venkatesan Ramya; Venkatachalam Madhu-Bala; Karuppiah Prakash-Shyam; Balakrishnan Gowdhami; Krishnamoorthy Sathiya-Priya; Kalimuthu Vignesh; Balasubramanian Vani; Balamuthu Kadalmani
Source:: Phytomedicine plus 2021 v.1 no.4 pp. 100142
ISSN:: 2667-0313
Subject:: Ayurvedic medicine; DNA fragmentation; Indigofera aspalathoides; acridine orange; adjuvants; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; cations; cell viability; cytotoxicity; dose response; ethanol; ethidium; fibroblasts; fluorescent dyes; homeostasis; humans; lime juice; membrane potential; methanol; mice; mitochondrial membrane; solvents; synergism; uterine cervical neoplasms
Abstract:: ... The folkloric use of Indigofera aspalathoides (Vahl) in anti-inflammatory and anti-cancer treatment dates back to circa 300 BC. However, reports on scientific validation for folkloric usage are not available yet. The objective of the study is to assess the cytotoxic potential of I. aspalathoides and to provide a rationale for its ethnopharmacological use with lime juice (ascorbic acid) as an adjuv ...
DOI:: 10.1016/j.phyplu.2021.100142
: https://doi.org/10.1016/j.phyplu.2021.100142

PubAg

Main content area

Limit your search

Text Availability

Journal

Publication Year

Subject

Search

693 Search Results

Search Results

1. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

2. Aqueous two-phase extraction of polysaccharides from Selaginella doederleinii and their bioactivity study

3. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris—In Vitro and In Vivo Studies

4. Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

5. Blue is not enough: biological activities of C‐phycocyanin extracts from Anabaena cylindrica

6. Chemical Profiling and Evaluation of Antioxidant and Anticancer Potential of Tuber Crop Amorphophallus commutatus var. wayanadensis

7. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

8. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

9. Effects of sulfation and carboxymethylation on Cyclocarya paliurus polysaccharides: Physicochemical properties, antitumor activities and protection against cellular oxidative stress

10. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

11. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

12. Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

13. Novel studies of characterization, antioxidant, anticoagulant and anticancer activity of purified polysaccharide from Hypsizygus ulmarius mushroom

14. Study of physicochemical, nutritional, and anticancer activity of Murraya Koenigii extract for its fermented beverage

15. The exploitation of rice husk biomass for the bio-inspired synthesis of gold nanoparticles as a multifunctional material for various biological and photocatalytic applications

16. A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species

17. A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

18. A novel biogenic Allium cepa leaf mediated silver nanoparticles for antimicrobial, antioxidant, and anticancer effects on MCF-7 cell line

19. Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves

20. Antibacterial activity of ethyl acetate extract of endophytic fungus (Paraconiothyrium brasiliense) through targeting dihydropteroate synthase (DHPS)

21. Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy

22. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated

23. Anticancer property of Selaginella bryopteris (L.) Bak. against hepatocellular carcinoma in vitro and in vivo

24. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

25. Antioxidant activity of two edible isothiocyanates: Sulforaphane and erucin is due to their thermal decomposition to sulfenic acids and methylsulfinyl radicals

26. Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer

27. Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response

28. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

29. Biofunctionalized silver nanoparticles synthesized from Passiflora vitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities

30. Chemical composition, antitumor and antioxidant effects of four lebanese plants extracts on human pulmonary adenocarcinoma

31. Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

32. Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole‐induced polycystic ovary syndrome in rats

33. Effects of Momordica cochinchinensis Aril Extract on Sterilized Low-Fat Milk, Antioxidant and Antiproliferative Activities

34. Effects of multi-mode divergent ultrasound pretreatment on the physicochemical and functional properties of polysaccharides from Sagittaria sagittifolia L

35. Evaluation of a novel phosphorylated corn straw xylan for enhancement of thermal stability, crystallinity and functional activity

36. Evaluation of biological activities of Barbarea integrifolia and isolation of a new glucosinolate derivated compound

37. Extraction of Zanthoxylum seed protein and identification of its simulated digestion products

38. Fruits of Ixora coccinea are a rich source of phytoconstituents, bioactives, exhibit antioxidant activity and cytotoxicity against human prostate carcinoma cells and development of RTS beverage

39. Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma

40. Ginger Extract Loaded into Chitosan Nanoparticles Enhances Cytotoxicity and Reduces Cardiotoxicity of Doxorubicin in Hepatocellular Carcinoma in Mice

41. Identification of Multi-Potent Protein Subtilisin A from halophilic bacterium Bacillus firmus VE2

42. Identification of bioactive metabolites from corn silk extracts by a combination of metabolite profiling, univariate statistical analysis and chemometrics

43. Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives

44. Improved water solubility, chemical stability, antioxidant and anticancer activity of resveratrol via nanoencapsulation with pea protein nanofibrils

45. In Vitro Evaluation of Antioxidant and Anticancer Activity of Lemongrass (Cymbopogon citratus (D.C.) Stapf)

46. Interactive 360° video to “Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis”

47. Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance

48. Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

49. LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

50. Microbial chitinases: properties, enhancement and potential applications

51. Multi-Functional Development and Utilization of Rapeseed: Comprehensive Analysis of the Nutritional Value of Rapeseed Sprouts

52. Notes on Culturable Endophytic Microorganisms Isolated from 14 Medicinal Plants in Vietnam: A Diversity Analysis to Predict the Host-Microbe Correlations

53. Novel Bacillus Milk-Clotting Enzyme Produces Diverse Functional Peptides in Semihard Cheese

54. Novel insights on the multi-functional properties of flavonol glucosides from red onion (Allium cepa L) solid waste – In vitro and in silico approach

55. Optimized ultrasound-assisted extraction of total polyphenols from Empetrum nigrum and its bioactivities

56. Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac)

57. Phytochemical analysis, in-vitro anti-proliferative, anti-oxidant, anti-diabetic, and anti-obesity activities of Rumex rothschildianus Aarons. extracts

58. Phytochemical components, antioxidant and anticancer activity of 18 major medicinal plants in Albaha region, Saudi Arabia

59. Polysaccharide from rubescens: extraction, optimization, characterization and antioxidant activities

60. Preparation and characterization of feruloylated oat β-glucan with antioxidant activity and colon-targeted delivery

61. Quercetin attenuates the cardiotoxicity of doxorubicin–cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple‐negative breast cancer

62. Schiff base 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide up-regulates the antioxidant status and inhibits the progression of Ehrlich solid tumor in mice

63. Shahatra (F.parviflora Lam)- a comprehensive review of its ethnopharmacology, phytochemistry and pharmacology

64. Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)

65. Simultaneous detection of anticancer compounds (Cucurbitacin I, B and E) and some pharmacological properties of Indian Blastania species

66. Sodium alginate nanofibers loaded Terminalia catappa scaffold regulates intrinsic apoptosis signaling in skin melanoma cancer

67. Sour black mulberry (Morus nigra L.) causes cell death by decreasing mutant p53 expression in HT-29 human colon cancer cells

68. Synthesis of Nanocapsules Based on Biosynthesized Nickel Nanoparticles and Potato Starch: Antimicrobial, Antioxidant, and Anticancer Activity

69. The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs’ Re-regulation: An in vitro Study on Human Malignant Melanoma Cells

70. The effects of quorum sensing molecule farnesol on the yield and activity of extracellular polysaccharide from Grifola frondosa in liquid fermentation