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You searched for: Subject term antioxidant activity Remove constraint Subject term: antioxidant activity Subject term melanoma Remove constraint Subject term: melanoma
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1. Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells

Author:
Weiyu Fu; Xuehua Liao; Qian Zhang; Yuzhen Zhu; Si Mei; Qian Li; Xin Zhou; Xiaojun Li; Hui Luo; Hua Ye; Kefeng Wu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 174
ISSN:
2662-7671
Subject:
Clausena lansium; Fourier transform infrared spectroscopy; Western blotting; alternative medicine; antioxidant activity; arabinose; enzymes; fruits; galactose; galacturonic acid; gel chromatography; glucose; glucuronic acid; humans; mannose; melanin; melanogenesis; melanoma; models; molecular weight; mushrooms; nuclear magnetic resonance spectroscopy; pectins; rhamnose; ribose; tyrosine; water solubility
Abstract:
... BACKGROUND: Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble polysaccharide in wampee, showed significant antioxidant activity, which was associated with the anti-melanogenic activity. Therefore, this study investigated the physicochemical ...
DOI:
10.1186/s12906-022-03646-6

2. Antibacterial, Antioxidant and Melanogenesis Inhibitory Activity of Auraptene, a Coumarin from Ferula szowitsiana Root

Author:
Ensiyeh Charmforoshan; Ehsan Karimi; Ehsan Oskoueian; Mehrdad Iranshahi
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1829-1836
ISSN:
1532-7914
Subject:
Clostridium perfringens; Escherichia coli; Ferula; Salmonella Typhimurium; Staphylococcus aureus; antibacterial properties; antioxidant activity; catalase; cell lines; coumarin; enzyme inhibition; fibroblasts; functional foods; glutathione peroxidase; humans; melanogenesis; melanoma; mice; nitric oxide; nutrition; superoxide dismutase; thiobarbituric acid; thiocyanates; Central Asia; Iran
Abstract:
... The auraptene is a geranyloxyn coumarin found in the Ferula species. The plant is endemic in Central Asia and it is used as a medicinal food in Iran. This research aimed to evaluate the antibacterial, antioxidant, and anti-melanogenic properties of auraptene, a coumarin from Ferula szowitsiana root. The results revealed that auraptene possessed antibacterial activity with minimum inhibitory and mi ...
DOI:
10.1080/01635581.2021.1962922

3. Ascorbate-and iron-driven redox activity of Dp44mT and Emodin facilitates peroxidation of micelles and bicelles

Author:
O.Yu. Selyutina; P.A. Kononova; V.E. Koshman; E.A. Shelepova; M. Gholam Azad; R. Afroz; M. Dharmasivam; Paul V. Bernhardt; N.E. Polyakov; D.R. Richardson
Source:
Biochimica et biophysica acta 2022 v.1866 no.4 pp. 130078
ISSN:
0304-4165
Subject:
antioxidant activity; cell membranes; drug therapy; electron paramagnetic resonance spectroscopy; emodin; hydrogen peroxide; ligands; lipid peroxidation; melanoma; micelles; oxidative stress
Abstract:
... Iron (Fe)-induced oxidative stress leads to reactive oxygen species that damage biomembranes, with this mechanism being involved in the activity of some anti-cancer chemotherapeutics. Herein, we compared the effect of the ligand, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), or the potential ligand, Emodin, on Fe-catalyzed lipid peroxidation in cell membrane models (micelles and bi ...
DOI:
10.1016/j.bbagen.2021.130078

4. Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System

Author:
Ernestine Nicaise Djuidje; Riccardo Barbari; Anna Baldisserotto; Elisa Durini; Sabrina Sciabica; Jan Balzarini; Sandra Liekens; Silvia Vertuani; Stefano Manfredini
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
Candida albicans; antioxidant activity; antioxidants; benzimidazoles; growth retardation; keratinophilic fungi; markets; melanoma; oxidative stress; radiation resistance; structure-activity relationships; sunscreens
Abstract:
... Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on benzimidazoles, we have devised a new series of isosteric benzothiazoles and investigated their antioxidant, photoprotective, antifun ...
DOI:
10.3390/antiox11020407

5. Bioaccessibility and intracellular antioxidant activity of phloretin embodied by gliadin/sodium carboxymethyl cellulose nanoparticles

Author:
Jing-Ru He; Jing-Jing Zhu; Shou-Wei Yin; Xiao-Quan Yang
Source:
Food hydrocolloids 2022 v.122 pp. 107076
ISSN:
0268-005X
Subject:
antioxidant activity; bioavailability; carboxymethylcellulose; cosmetics; electrostatic interactions; encapsulation; erythrocytes; food industry; gliadin; glutathione peroxidase; heat treatment; hemolysis; hydrocolloids; hydrogen bonding; malondialdehyde; melanoma; mice; pH; protective effect; reactive oxygen species; superoxide dismutase; ultraviolet radiation; water solubility
Abstract:
... In this work, gliadin/sodium carboxymethyl cellulose nanoparticles (G/CMC) were prepared to encapsulate bioactive phloretin (Phl) for improving the stability and bioaccessibility by simple antisolvent precipitation. Scanning electron microscopy (SEM) and dynamic light scattering showed that G/CMC nanoparticles were spherical with the diameter below 350 nm. Electrostatic interaction and hydrogen bo ...
DOI:
10.1016/j.foodhyd.2021.107076

6. Characterization of goat whey proteins and their bioactivity and toxicity assay

Author:
Maria Isabel Ferreira Campos; Paula Perazzo de Souza Barbosa; Laura Junqueira Camargo; Luciano Da Silva Pinto; Bianca Mataribu; Catarina Serrão; Luis Fernando Marques-Santos; José Honório Lopes; Julia Mariano Caju de Oliveira; Carlos Alberto de Almeida Gadelha; Tatiane Santi-Gadelha
Source:
Food bioscience 2022 v.46 pp. 101591
ISSN:
2212-4292
Subject:
Artemia franciscana; Escherichia coli; Listeria monocytogenes; Pseudomonas aeruginosa; Salmonella; Staphylococcus aureus; acute toxicity; antibacterial properties; antioxidant activity; byproducts; food industry; goats; humans; ingredients; larvae; melanoma; nutrient content; nutritive value; oxidation; polyacrylamide gel electrophoresis; toxicity testing; whey
Abstract:
... Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential, where proteins have a high biological value and play an important role in the organism's physiology. Therefore, the aim of this study was to identify, quantify, concentrate and investigate the capacity of goat whey proteins to perform different ...
DOI:
10.1016/j.fbio.2022.101591

7. Differential Induction of Reactive Oxygen Species and Expression of Antioxidant Enzymes in Human Melanocytes Correlate with Melanin Content: Implications on the Response to Solar UV and Melanoma Susceptibility

Author:
Parth R. Upadhyay; Renny J. Starner; Viki B. Swope; Kazumasa Wakamatsu; Shosuke Ito; Zalfa A. Abdel-Malek
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
antioxidant activity; eumelanin; glutamate-cysteine ligase; glutathione; heme oxygenase (biliverdin-producing); humans; irradiation; lipid peroxidation; melanocytes; melanoma; pigmentation; protein subunits; reactive oxygen species; risk; ultraviolet radiation; viability
Abstract:
... Constitutive pigmentation determines the response to sun exposure and the risk for melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes, we compared the effects of constitutive pigmentation on their antioxidant response to solar UV. The quantitation of eumelanin and pheomelanin showed that the eumelanin content and eumelanin to pheomelanin ratio correlated invers ...
DOI:
10.3390/antiox11061204

8. Drying methods influence the physicochemical and functional properties of seed-used pumpkin

Author:
Erpeng Chao; Jianjun Tian; Liuping Fan; Tao Zhang
Source:
Food chemistry 2022 v.369 pp. 130937
ISSN:
0308-8146
Subject:
air; antioxidant activity; antioxidants; ascorbic acid; coumaric acids; food chemistry; melanin; melanoma; polyphenols; pumpkins; terrestrial radiation
Abstract:
... The effects of far-infrared radiation drying (FIRD), freeze drying (FD), vacuum drying (VD), and hot air drying (HAD) on appearance, physicochemical properties, antioxidant activities, antityrosinase capacity using B16F10 melanoma cell from seed-used pumpkins (hull-less pumpkin and hull pumpkin) were evaluated. Results suggested that hull-less pumpkin (HLP) dehydrated by FIRD provided the highest ...
DOI:
10.1016/j.foodchem.2021.130937

9. Effect of Grass Carp Scale Collagen Peptide FTGML on cAMP-PI3K/Akt and MAPK Signaling Pathways in B16F10 Melanoma Cells and Correlation between Anti-Melanin and Antioxidant Properties

Author:
Zizi Hu; Xiaomei Sha; Lu Zhang; Sheng Huang; Zongcai Tu
Source:
Foods 2022 v.11 no.3 pp. -
ISSN:
2304-8158
Subject:
Ctenopharyngodon idella; Danio rerio; antioxidant activity; collagen; gelatin; hydrolysates; melanin; melanogenesis; melanoma; mice; mushrooms; oligopeptides; reactive oxygen species
Abstract:
... Peptide Phe-Thr-Gly-Met-Leu (FTGML) is a bioactive oligopeptide with tyrosinase inhibitory activity derived from gelatin hydrolysate of grass carp scales. Previous studies have shown that FTGML addition can effectively inhibit mushroom tyrosinase activity in vitro, and also has some effect on the inhibition of melanogenesis in zebrafish in vivo, but the underlying mechanism is not fully understood ...
DOI:
10.3390/foods11030391

10. Food plant with antioxidant, tyrosinase inhibitory and antimelanoma activity: Prunus mahaleb L

Author:
Zühal Bayrakçeken Güven; Zeynep Dogan; Iclal Saracoglu; Laurent Picot; Akito Nagatsu; A. Ahmet Basaran
Source:
Food bioscience 2022 v.48 pp. 101804
ISSN:
2212-4292
Subject:
Prunus mahaleb; antioxidant activity; antioxidants; cell growth; chemical constituents of plants; dose response; endocarp; flavonols; food plants; gallic acid; growth retardation; industry; melanoma; spices; ursolic acid
Abstract:
... Prunus mahaleb L. seeds are used as spice and folk remedies in many countries. The aim of this study was bioactivity guided isolation and characterization phytoconstituents of P. mahaleb which have been studied very limited so far. The antioxidant capacities of seed and kernel (endocarp) extracts were studied by DPPH, nitric oxide (NO), superoxide (SO), TEAC, CUPRAC methods. The antiproliferative ...
DOI:
10.1016/j.fbio.2022.101804

11. Phytochemical Characterization of Taxus baccata L. Aril with Emphasis on Evaluation of the Antiproliferative and Pro-Apoptotic Activity of Rhodoxanthin

Author:
Daria-Antonia Dumitraş; Andrea Bunea; Dan Cristian Vodnar; Daniela Hanganu; Emoke Pall; Mihai Cenariu; Adrian Florin Gal; Sanda Andrei
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
Taxus baccata; antioxidant activity; apoptosis; aril; carotenoids; cell lines; chromatography; cytotoxicity; dose response; ethyl acetate; flavonoids; humans; keratinocytes; melanoma; methanol; mice; oxidative stress; petroleum; protective effect; trees
Abstract:
... Taxus baccata L., an evergreen tree, was known until recently due to its high concentration of toxic compounds. The purpose of the present study was to focus on the only non-poisonous part, the red arils, which have recently been described as an important source of various bioactive constituents. To establish total phenolic, flavonoid, and carotenoid content, antioxidant capacity, and cytotoxic pr ...
DOI:
10.3390/antiox11061039

12. Sodium alginate nanofibers loaded Terminalia catappa scaffold regulates intrinsic apoptosis signaling in skin melanoma cancer

Author:
Lakshmanan Muthulakshmi; Selvakani Prabakaran; Vaikundamoorthy Ramalingam; A. Varada Rajulu; Marriappan Rajan; Seeram Ramakrishna; Hongrong Luo
Source:
Process biochemistry 2022 v.118 pp. 92-102
ISSN:
1359-5113
Subject:
Fourier transform infrared spectroscopy; Terminalia catappa; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cancer therapy; caspase-9; cytotoxicity; medicinal plants; melanoma; mitochondria; nanofibers; polymers; skin (animal); skin neoplasms; sodium alginate
Abstract:
... Drug delivery by nanofibrous scaffold is a promising approach for treating cancer disease. In this study, bioactive compounds were extracted from the medicinal plant Terminalia catappa and loaded into sodium alginate (SA) polymer to prepare a bioactive electrospun nanofibers. Initially, SA polymeric fibers alone was prepared by electrospinning approach and characterized by FT-IR spectroscopy, XRD ...
DOI:
10.1016/j.procbio.2022.04.004

13. The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs’ Re-regulation: An in vitro Study on Human Malignant Melanoma Cells

Author:
Dilara Kamer Colak; Unal Egeli; Isil Ezgi Eryilmaz; Onder Aybastier; Hulusi Malyer; Gulsah Cecener; Berrin Tunca
Source:
Nutrition and cancer 2022 v.74 no.1 pp. 211-224
ISSN:
1532-7914
Subject:
Dittrichia viscosa; antineoplastic activity; antioxidant activity; apoptosis; cell cycle checkpoints; chromatography; drug therapy; fibroblasts; humans; melanoma; methanol; microRNA; nutrition; phenolic compounds; skin neoplasms
Abstract:
... Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy’s limited effect. In the present study, we evaluated the anticancer potentials of Inula viscosa methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferati ...
DOI:
10.1080/01635581.2020.1869791

14. The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)

Author:
Agnieszka Synowiec-Wojtarowicz; Katarzyna Pawłowska-Góral; Agata Krawczyk; Stanisław Gawron; Magdalena Kimsa-Dudek
Source:
Molecular biology reports 2022 v.49 no.4 pp. 3157-3165
ISSN:
0301-4851
Subject:
antioxidant activity; baicalin; catalase; gene expression; gene expression regulation; glutathione peroxidase; homeostasis; magnetic fields; melanoma; molecular biology; protein content; superoxide dismutase
Abstract:
... BACKGROUND: Baicalin and baicalein have antioxidant, anti-inflammatory, hepatoprotective and anti-cancer properties. However, it is not known how a static magnetic field will modify these properties. Therefore, the aim of our study was to evaluate the simultaneous exposure of melanoma cells to flavones and the static magnetic fields that are generated by permanent magnets on the gene expression an ...
DOI:
10.1007/s11033-022-07148-z

15. Valorization potential of Plantago major L. solid waste remaining after industrial tincture production: Insight into the chemical composition and bioactive properties

Author:
Marija Petrović; Marina Jovanović; Steva Lević; Viktor Nedović; Dragana Mitić-Ćulafić; Tanja Živković Semren; Sonja Veljović
Source:
Waste and biomass valorization 2022 v.13 no.3 pp. 1639-1651
ISSN:
1877-2641
Subject:
Plantago major; antibacterial properties; antioxidant activity; biomass; chemical composition; chlorogenic acid; colorectal neoplasms; cosmetics; cytotoxicity; food plants; humans; industry; liquids; luteolin; melanoma; phenolic compounds; rutin; solid wastes
Abstract:
... PURPOSE: Herbal residues from the production and processing of medicinal plants are usually discarded as waste material. Plantago major is an edible plant, traditionally used for medicinal purposes, having wide application in the pharmaceutical and cosmetics industry, usually in the form of liquid extracts and tinctures. In this work, extracts of P. major leaves waste remaining after industrial ti ...
DOI:
10.1007/s12649-021-01608-6

16. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated

Author:
Shabir Ahmad Ganai; Farooq Ahmad Sheikh; Zahoor Ahmad Baba; Mudasir Ahmad Mir; Mohd Ayoob Mantoo; Manzoor Ahmad Yatoo
Source:
Phytotherapy research 2021 v.35 no.7 pp. 3509-3532
ISSN:
0951-418X
Subject:
DNA methylation; antineoplastic activity; antioxidant activity; brain neoplasms; breast neoplasms; colorectal neoplasms; cytotoxicity; epigenetics; histone deacetylase; liver; lung neoplasms; luteolin; melanoma; pancreatic neoplasms; phytotherapy; prostatic neoplasms; research
Abstract:
... Various signaling mechanisms contribute significantly to the development of multiple cancers. Small molecules with the potential of influencing a wide variety of molecular targets may prove as broad‐spectrum anticancer agents. Flavonoids from plant sources are strongly emerging as promising antineoplastic molecules because of their ability to hamper different cancer‐driving signaling pathways. Fur ...
DOI:
10.1002/ptr.7044

17. Antityrosinase and antioxidant activity of asparagus and its inhibition on B16F10 melanoma cells before and after hydrothermal treatment

Author:
Qun Yu; Liuping Fan
Source:
Food bioscience 2021 v.41 pp. 101026
ISSN:
2212-4292
Subject:
antioxidant activity; cell structures; cell viability; coumaric acids; gallic acid; hot water treatment; melanin; melanoma; mice; polyphenols
Abstract:
... In this study, we compared the effects of asparagus polyphenol extract (ASE) and asparagus polyphenol extract after hydrothermal treatments (ASEH) on antityrosinase and antioxidant activity, in addition to murine melanoma B16F10 cells. The intracellular experiments of four fractions, including cell morphology, cell viability, melanin content and intracellular tyrosinase activity were evaluated aft ...
DOI:
10.1016/j.fbio.2021.101026

18. Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Author:
Mariangela Marrelli; Maria Rosaria Perri; Valentina Amodeo; Francesca Giordano; Giancarlo A. Statti; Maria Luisa Panno; Filomena Conforti
Source:
Plants 2021 v.10 no.1 pp. -
ISSN:
2223-7747
Subject:
Apiaceae; aerial parts; antioxidant activity; apoptosis; bergapten; cells; cytotoxicity; dosage; drugs; extraction; extracts; humans; maceration; melanoma; methoxsalen; photochemotherapy; phytochemicals; quantitative analysis; sampling; skin neoplasms; ultraviolet radiation; Italy
Abstract:
... Photochemotherapy is one of the most interesting current therapeutic approaches for the treatment of melanoma. Different classes of naturally occurring phytochemicals demonstrated interesting photoactive properties. The aim of this study was to evaluate the photocytotoxic potential of two Cachrys species from Southern Italy: C. sicula and C. libanotis (Apiaceae). The enriched-coumarin extracts wer ...
DOI:
10.3390/plants10010123

19. Biological potential of hydroalcoholic extracts of Physalis pubescens L

Author:
Tailise Beatriz Roll Zimmer; Deborah Murowaniecki Otero; Nathalia Stark Pedra; Natália Pontes Bona; Leticia Zarnott; Roselia Maria Spanevello; Eliezer Avila Gandra; Rui Carlos Zambiazi
Source:
Biocatalysis and agricultural biotechnology 2021 v.31 pp. 101895
ISSN:
1878-8181
Subject:
2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; Listeria monocytogenes; Physalis pubescens; Staphylococcus aureus; agricultural biotechnology; antibacterial properties; antioxidant activity; antioxidants; astrocytes; biocatalysis; cell viability; epicatechin; glioblastoma; high performance liquid chromatography; melanoma; mice; pulp
Abstract:
... The antioxidant, antibacterial, and antitumor effects of hydroalcoholic extracts of the pulp and seeds of Physalis pubescens L. were explored. The components of the extracts were identified and quantified by high-performance liquid chromatography (HPLC). The antioxidant activity was determined by 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), an ...
DOI:
10.1016/j.bcab.2020.101895

20. Chemical and Biological Characterization of the Anticancer Potency of Salvia fruticosa in a Model of Human Malignant Melanoma

Author:
Sotiris Kyriakou; Venetia Tragkola; Michael Plioukas; Ioannis Anestopoulos; Paschalina S. Chatzopoulou; Eirini Sarrou; Dimitrios T. Trafalis; Maria V. Deligiorgi; Rodrigo Franco; Aglaia Pappa; Mihalis I. Panayiotidis
Source:
Plants 2021 v.10 no.11 pp. -
ISSN:
2223-7747
Subject:
Salvia fruticosa; analytical kits; antioxidant activity; apoptosis; carcinoma; caspases; cytotoxicity; flavonoids; humans; keratinocytes; lipid peroxidation; melanocytes; melanoma; models; oxidation; skin neoplasms; therapeutics
Abstract:
... Malignant melanoma is one of the most aggressive types of skin cancer with an increasing incidence worldwide. Thus, the development of innovative therapeutic approaches is of great importance. Salvia fruticosa (SF) is known for its anticancer properties and in this context, we aimed to investigate its potential anti-melanoma activity in an in vitro model of human malignant melanoma. Cytotoxicity w ...
DOI:
10.3390/plants10112472