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Emanuel Paula Magalhães; Brenna Pinheiro Silva; Natália Luna Aires; Lyanna Rodrigues Ribeiro; Arif Ali; Mariana Maciel Cavalcanti; João Victor Serra Nunes; Tiago Lima Sampaio; Ramon Róseo Paula Pessoa Bezerra de Menezes; Alice Maria Costa Martins
... Amphotericin B (AmB), used for systemic fungal infections, has a limited clinical application because of its high nephrotoxicity. Natural antioxidant and anti-inflammatory substances have been widely studied for protection against drug-induced nephrotoxicity. α-Bisabolol (BIS) has demonstrated a nephroprotective effect on both in vitro and in vivo models. The aim of this work was to evaluate the e ...
... Lead has long been known as neurotoxic and immunotoxic heavy metal in human and animals including fish, whereas, 2, 3-dimethylsuccinic acid (DMSA) and fulvic acid (FA) are well-known biological chelators. The present investigation was carried out to assess the potential chelating and antioxidant effects of dietary supplementation with DMSA and FA against lead acetate (Pb)-induced oxidative stress ...
... 2-Mercaptoethanol (2-ME) is often used as an antioxidant to optimize culture systems for in vitro oocyte maturation in livestock. However, the relationship between 2-ME and autophagy has not yet been elucidated. In this study, we hypothesized that 2-ME can promote porcine oocyte maturation in vitro by maintaining autophagy homeostasis. To test this hypothesis, we explored the effects of 2-ME on th ...
Ashley L. Farris; Dennis Lambrechts; Yuxiao Zhou; Nicholas Y. Zhang; Naboneeta Sarkar; Megan C. Moorer; Alexandra N. Rindone; Ethan L. Nyberg; Alexander Perdomo-Pantoja; S.J. Burris; Kendall Free; Timothy F. Witham; Ryan C. Riddle; Warren L. Grayson
... Low oxygen (O₂) diffusion into large tissue engineered scaffolds hinders the therapeutic efficacy of transplanted cells. To overcome this, we previously studied hollow, hyperbarically-loaded microtanks (μtanks) to serve as O₂ reservoirs. To adapt these for bone regeneration, we fabricated biodegradable μtanks from polyvinyl alcohol and poly (lactic-co-glycolic acid) and embedded them to form 3D-pr ...
Angelica sinensis; acetylcysteine; antioxidants; autophagy; cell senescence; flavonoids; longevity; mitogen-activated protein kinase; models; oxidative stress; phosphorylation; photoaging; signal transduction; therapeutics
Abstract:
... Aging can lead to the occurrence of many degenerative diseases, and the most intuitive consequences are mainly manifested on the skin, which is affected by both endogenous and exogenous aging factors and can be used as an ideal model organ for studying aging. 4,4′-Dimethoxychalcone (DMC), a natural flavonoid compound from Angelica sinensis, has been proven to prolong the lifespan of multiple speci ...
... Hyperglycemia induced diabetic complications as well as dysfunction of multiple organs is closely related to the increased inflammation and oxidative stress (OS). 4-hydroxyisoleucine (4-HIL), a major constituent of Trigonella foenum-graecum L. shown to have anti-diabetic effects. However, its potential mechanism against diabetic complications in the model of metabolic syndrome have not yet been ch ...
... Chronic kidney disease (CKD) produces multiple repercussions in the gastrointestinal tract (GIT), such as alterations in motility, gut microbiota, intestinal permeability, and increased oxidative stress. However, despite enteric glial cells (EGC) having important neural and immune features in GIT physiology, their function in CKD remains unknown. The present study investigates colonic glial marker ...
... In this study, to increase the content of quercetin in the isolates obtained from the white and red onion scales, in accordance with the zero waste philosophy, using water as an environmentally and healthy friendly extractant, a mathematical model was constructed, based on the Central Composite Design. The suitability of the model for the accurate and quick study of complex relationships was demon ...
... OBJECTIVES: Selenium plays an indispensable role in antioxidant and antiinflammation processes. Oxidative stress and inflammation have been hypothesized to be involved in the pathogenesis of cartilage degeneration. We sought to examine the association between plasma selenium levels and the prevalence of radiographic osteoarthritis (ROA). DESIGN: A population-based cross-sectional study. SETTING AN ...
Alnus glutinosa; Ribes nigrum; Rosa canina; Rosmarinus officinalis; Tilia tomentosa; antioxidants; chemical composition; ethanol; glycerol; glycosylation; high performance liquid chromatography; maceration; meristems; nucleosides; quality control; rutin; solid phase extraction; solvents
Abstract:
... Concentrated bud macerates (CBMs) are obtained from meristematic tissues such as buds and young shoots by maceration in a solvent composed of glycerin, water and ethanol (1/1/1/, v/v). Their traditional utilization in gemmotherapy has gained interest in the past years, and the knowledge of their chemical characterization can provide commercial arguments, particularly to secure their quality contro ...
... This study reports the extraction of anthocyanins from P. cauliflora peels, its partial characterization and the inclusion into a halochromic film based on cashew gum polysaccharide and polyvinyl alcohol (CGP/PVA). Three kinds of extractions were performed: The classic acidic-alcoholic solvent method; enzymatic method with the cell wall degrading enzymes (cellulase and pectinase) and the combinati ...
... The effects of an exogenous application of various concentrations and dipping duration of melatonin (MT) treatment on postharvest senescence, quality, chilling tolerance, and antioxidant metabolism of mango fruit cv. “Dashehari” were examined. Fruits were treated with three concentrations of MT (50, 100, or 150 µM), each applied for three times (60, 90, or 120 min), followed by storage at 5 ± 1°C. ...
... Sulfur is an essential element for life. However, the soil microbe Pseudomonas (P.) fluorescens can survive in a low sulfur environment. When cultured in a sulfur-deficient medium, the bacterium reprograms its metabolic pathways to produce α-ketoglutarate (KG) and regenerate this keto-acid from succinate, a by-product of ROS detoxification. Succinate semialdehyde dehydrogenase (SSADH) and KG decar ...
... With the progressive loss of fungicide efficacy against Phakopsora pachyrhizi, the causal agent of Asian soybean rust (ASR), alternative methods to protect soybean crops are needed. Resistance induction is a low impact alternative and/or supplement to fungicide applications that fortifies innate plant defenses against pathogens. Here, we show that a microbial fermentation product (MFP) induces pla ...
... This study used the properties of amino acid residues to screen antioxidant peptides from hazelnut protein. It was confirmed that the type and position of amino acid residues, grand average of hydropathy, and molecular weight of a peptide could be comprehensively applied to obtain desirable antioxidants after analyzing the information of synthesized dipeptides and BIOPEP database. As a result, six ...
... The feasible application of additive manufacturing in the food and pharmaceutical industries strongly depends on the development of highly stable inks with bioactive properties. Surface-modified microcrystalline cellulose (MCC) shows the potential of being a useful particulate (i.e., Pickering)-type emulsifier to stabilize emulsions. To attain desired therapeutic properties, MCC can also be tuned ...
... Currently, there is growing interest in screening and quantifying antioxidants from biological samples in the quest for natural and effective antioxidants to combat free radical-related pathological complications. Antioxidants play an important role in human health and provide a defense against many diseases. Due to the valuable dietary role of these compounds, the analysis and determination of th ...
... : The extracts of Garcinia mangostana (L) pericarp contain high concentration of prenylated xanthones such as α-, β- and γ-mangostin and related molecules. These extracts possess wide range of biological properties including anticancer, anti-inflammatory, anti-proliferative, antioxidant and pro-apoptotic activities. Till date, α-, β- and γ-mangostin have been extensively studied due to its applica ...
antioxidants; ass milk; breast milk; cheeses; dried milk; fermentation; horses; humans; ice cream; lactation; lactose; manufacturing; milk; systematic review; therapeutics; veterinary medicine
Abstract:
... In addition to providing individualized, specific, and ample nutritional compounds, donkey milk (DM) offers immunological modulation during health and disease. Recently, DM has attracted major interest in preparing infant formulas due to its similarity to human milk in terms of high protein and lactose content and low-fat concentration. The antimicrobial, anti-inflammation, antioxidant, and hypo-a ...
... Olive mill wastewater, a high polyphenols agro-food by-product, was successfully exploited in an eco-friendly radical process to synthesize an antioxidant macromolecule, usefully engaged as a functional ingredient to prepare functional puddings. The chemical composition of lyophilized olive mill wastewaters (LOMW) was investigated by HPLC-MS/MS and ¹H-NMR analyses, while antioxidant profile was in ...
Arabidopsis; antioxidants; blueberries; endophytes; fungi; plant growth; salt stress; salt tolerance; stress tolerance; transcription factors
Abstract:
... Dark septate endophytes (DSEs) have attracted much attention due to their positive roles in plant growth as well as resistance to various abiotic stresses. However, there are no reports on the molecular mechanisms of DSE fungi to improve salt tolerance in plants. In this study, the blueberry seedlings inoculated with T010, a beneficial DSE fungus reported previously, grew more vigorously than the ...
... To solve the problem of environmental pollution caused by plastic food packaging films, a biodegradable chitosan-based film containing micro ramie fibre and lignin was prepared by the casting method. With the addition of different ratios of ramie fibre and lignin to the chitosan matrix, a significant improvement in mechanical, water resistance, thermal, and antioxidant properties was observed. The ...
... Guided tissue regeneration (GTR) is the main therapeutic method for periodontal tissue regeneration. The key to the GTR strategy is the membrane which can assist the reconstruction of bone tissue in the periodontal defect and prevent the migration of epithelium and fibroblasts to the defect. However, the existing periodontal membrane cannot effectively promote periodontal tissue regeneration due t ...
Prunus avium; Rana; agroecology; anthocyanins; antioxidants; cherries; cultivars; fruit weight; fruits; human nutrition; mineral content; multivariate analysis; potassium; surface area; Croatia
Abstract:
... Outstanding organoleptic characteristics make sweet cherries one of the most popular seasonal fruits, as it has numerous health benefits making it an increasingly important part of the human diet. This study was conducted to evaluate various physicochemical properties of nine introduced and five local sweet cherry cultivars. Rana Stonska had the lowest measured content of phenols, flavonoids, and ...
... A novel pretreatment system containing deep eutectic solvents and ethanol (DES-E) for synergistic carbohydrate conversion and delignification was reported in this study. The DES-E pretreatment resulted in an enhanced glucose yield compared to individual DES and ethanol pretreatment for the three tested biomass, including Broussonetia papyrifera, corn stover and pine. To further explore the deligni ...
... Slightly acidic electrolyzed water (SAEW) is often used as a disinfectant in beef preservation to ensure microbiological safety. However, it ineffectively inhibit lipid oxidation. Therefore, the combination of SAEW and tea polyphenols (TPs) was tested to inhibit lipid oxidation and microbial growth in beef preservation. SAEW and TPs were selected as the optimum sanitizer and antioxidant, respectiv ...
... Gold nanoparticles are synthesized by reducing Au ions using the liquid metabolic waste of Indian Gir cow (A-2) urine. Various bio-molecules present in cow urine are effectively used to reduce gold ions to gold nanoparticles in a single step. The synthesized nanomaterials were characterized using advanced characterizations which ensures the formation of gold in nano form. We characterized the comm ...
... Rhus chinensis Mill., firstly recorded as herbal medicine in Shan Hai Jing, have been used for thousands of years to treat various diseases. This review targets on the ethnomedicinal applications of R. chinensis and to gather the phytochemical, pharmacological and toxicological data which support the therapeutic potential of R. chinensis in treatment on different diseases, with emphasis on the nat ...
Garcinia; adverse effects; antioxidants; benzophenones; biomedical research; chemical constituents of plants; drugs; ethnobotany; flavonoids; mechanism of action; terpenoids; toxicology; traditional medicine; xanthones; South East Asia
Abstract:
... The tropical plants of Garcinia (Clusiaceae family) have been extensively used in folk medicine apart from its limited use in the preparation of certain dishes. This paper aims to provide a comprehensive and updated report on the diverse range of phytochemicals, the traditional uses, the nutritional values, the major pharmacological attributes, and the toxicological findings of ten Garcinia plants ...
... Lotus is a member of a small family of Nelumbonaceae and is regarded as a sacred flower grown as a freshwater aquatic plant. All plant parts are utilized as food and medicine. Lotus seed (LS) is an important part of the lotus plant due to its nutritional and bioactive components. The presence of phenolic compounds imparts numerous bioactivities to the LS extracts. Nutritional composition is consid ...
... Currently, research on natural products is facing challenging future in various aspects. A large group of natural polysaccharides such as β-glucan, cellulose, hemicellulose, chitin, pectin, agaropectin, heteroglycans, lignins, hydrocolloids, homopolysaccharides, heteropolysaccharides were studied extensively for their various therapeutical potential. Several research works have already demonstrate ...
... Celastrol has attracted great attention owing to its anti‐arthritis, antioxidant, and anticancer activities. Nevertheless, its metabolism in vivo (rats) and in vitro (rat liver microsomes and intestinal flora) has not been comprehensively characterized. In this study, ultra‐high‐performance liquid chromatography coupled with hybrid triple quadrupole time‐of‐flight mass spectrometry was used as a r ...
... Okra fruit (Abelmoschus esculentus (L.) Moench) has been extensively used for the treatment of skin damage and subcutaneous tissue abscess for many years in Turkish folk medicine.In this study, we aimed to investigate the wound healing potential of okra fruit by in vitro and in vivo experimental models in detail. Furthermore, based on the results of experiments, a wound healing formulation was dev ...
... Ginsenoside Re (Re) belongs to protopanaxatriol saponins and exists in Panax ginseng, Panax quinquefolium, Panax notoginseng, and other plants in the Araliaceae family. Re has recently become a research focus owing to its pharmacological activities and benefits to human bodies. To summarize recent findings regarding the pharmacological effects and mechanisms of Re and highlight and predict the pot ...
... Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the com ...
... BACKGROUND: Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory, antioxidant, and antiulcer properties. AIM: To investigate the effect of FREG (GutGard®) on restoring intestinal barrier function in tumor necrosis factor- ...
... Manufacturing facile and low-cost wound dressings that simultaneously meet the needs of the entire repair process remains the major challenge of effective wound healing. Herein, a series of curdlan-tannic acid hybrid hydrogels were successfully fabricated through the annealing technique. Notedly, when the mixing weigh ratio was 1:1, the hydrogel exhibited excellent physicochemical properties, incl ...
Pedro Rojas-Morales; Juan Carlos León-Contreras; Mónica Sánchez-Tapia; Alejandro Silva-Palacios; Agustina Cano-Martínez; Susana González-Reyes; Angélica Saraí Jiménez-Osorio; Rogelio Hernández-Pando; Horacio Osorio-Alonso; Laura Gabriela Sánchez-Lozada; Armando R. Tovar; José Pedraza-Chaverri; Edilia Tapia
... Ischemic kidney injury is a common clinical condition resulting from transient interruption of the kidney's normal blood flow, leading to oxidative stress, inflammation, and kidney dysfunction. The ketogenic diet (KD), a low-carbohydrate, high-fat diet that stimulates endogenous ketone body production, has potent antioxidant and anti-inflammatory effects in distinct tissues and might thus protect ...
acyl coenzyme A; antioxidants; liquid chromatography; tandem mass spectrometry
Abstract:
... This study describes LC-ESI-MS/MS method that covers the analysis of various cellular acyl-CoA in a single injection. The method is based on a quick extraction step eliminating LLE/SPE clean up. Method performance characteristics were determined after spiking acyl-CoA standards in different concentrations into a surrogate matrix. The extensive matrix effect for most acyl-CoA except for palmitoyl-C ...
... Hydrogel-based wound dressings with tissue adhesion abilities are widely used for wound closure. However, currently developed hydrogel adhesives are still poor at continuing to seal wounds while bleeding is ongoing. Herein, we demonstrate an antibacterial and hemostatic hydrogel adhesive with low-swelling properties and toughness for wound healing. The hydrogel was composed of Pluronic F127 diacry ...
adsorption; antioxidants; chickpeas; emulsions; food research; lipid peroxidation; particle size; pea protein; sodium caseinate; viscosity; whey protein isolate; zeta potential
Abstract:
... In this study, effects of two animal–based and two plant–based proteins on the stability of W/O emulsions were evaluated. On physical stability, turbiscan stability index values showed that the trend of protein–added emulsion followed the order: whey protein isolate (WPI) < sodium caseinate (CAS) < pea protein isolation (PPI) < chickpea protein isolation (CPI). On chemical stability, the inhibitio ...
... The 7S fraction contains several major allergens of soybean protein. Here, the effects of covalent modification by chlorogenic acid (CHA) and (−)-epigallo-catechin 3-gallate (EGCG) on the allergenicity and functional properties of soybean 7S protein were investigated. Conjugation with EGCG and CHA resulted in the formation of cross-linked protein polymers and changes to the structures of the prote ...
Larissa M. Magnibou; Peron B. Leutcha; Billy T. Tchegnitegni; Steven C. N. Wouamba; Cyrille Y. F. F. Magne; Abel J. G. Yaya; Theodora Kopa; Maurice F. Tagatsing; Nantenaina Tombozara; Alain L. Meli; Celine Henoumont; Sophie Laurent; Emmanuel Talla
... Entada abyssinica Steud. Ex A. Rich (Leguminosae) is a medicinal plant used traditionally for the treatment of infections. A phytochemical investigation of the methanol extract of E. abyssinica root bark led to the isolation of a new phenanthrene derivative named phenentada (1), together with seven known compounds (8 S, 13 E)-kolavic acid 15-methyl ester (2) and 8 S-kolavic acid 15-methyl ester (3 ...
... Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various spectroscopic techniques. A new compound named as Squalen-1-ol, Phytol, squalene ...
antioxidants; black tea; detection limit; electric current; food chemistry; gallic acid; humans; rapid methods; xenon
Abstract:
... Gallic acid (GA) is found in a wide range of natural plants and is relevant to the health of human beings. Here, a photoelectrochemical sensing platform based on g-C₃N₄@CNT heterojunction has been prepared for the highly sensitive and selective detection of GA. Under the light of xenon lamp, the photocurrent of g-C₃N₄@CNT is 7 times higher than that of g-C₃N₄. And the sensor generates 4 times more ...
... In the present study we investigated the performance of a panel of 13 solid sorbents comprising layered double hydroxides, zirconium phosphate-based materials, and phyllosilicates as heterogeneous supports for the concentration of pomegranate (Punica granatum L.) juice. Mg-containing clays exhibited an almost complete bleaching capacityof pomegranate juice and more interestingly provided blends wi ...
... The present study reports the production, extraction, partial characterization, biological activities and use in textile dyeing of an orange pigment from Metabacillus idriensis strain LipT27 (MN818522.2). Pigment production occurred with 400 µg carotenoid/g biomass yield. Characterization of the methanol extracts of pigment by UV–Visible spectrophotometry, TLC, NMR, and FTIR indicated that the pig ...
... A novel thioether chitosan oligosaccharide (COS-All-Tio) was prepared by the reaction of chitosan oligosaccharide (COS) with 3-bromopropene, followed by the coupling with tiopronin (Tio) using a thiol-ene reaction. The degree of substitution of COS-All-Tio reached 1.48. The structure of COS-All-Tio was identified by IR, NMR spectra. It was found that COS-All-Tio possessed more potent antioxidant a ...
... Novel films based on watermelon peel pectin (WMP) incorporated with purple cabbage extract (PCE) were developed for monitoring the freshness of mutton. The FTIR result showed that WMP and PCE interacted through hydrogen bonds. Low PCE content (≤1.5%) could be well dispersed in the film matrix, resulting in an enhancement in light transmittance, mechanical properties, barrier properties, and therma ...
Paeonia lactiflora; amino acids; antioxidants; catechin; catechol oxidase; gallic acid; high performance liquid chromatography; mass spectrometry; traditional medicine; China
Abstract:
... The root of Paeonia lactiflora is a traditionally-used whitening medicine in China for thousands of years. Although some tyrosinase inhibitors and/or antioxidants such as 1,2,3,4,6-pentagalloylglucose, gallic acid, have been isolated and identified, their tyrosinase inhibition pathway (monophenolase or diphenolase inhibition, or both two) have not been systematically studied and the underlying tyr ...