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... Twelve horses and 3 mules with grade II or louder prolonged diastolic murmurs were selected for functional and histopathologic study. Aortic insufficiency was demonstrated in all mules and in all except two horses on the basis of murmurs, jet lesions and/or pathologic and incompetent valve cusps. In 15 control animals lesions resulting in aortic insufficiency were not found. A thick fibrous band w ...
... A malformation of the heart and great vessels, in which the aorta and the pulmonary trunk originated from the right ventricle, has been reported in a 1 1/2 year-old horse. It is suggested that the oxygenated blood from the left ventricle was ejected through a large septal defect into the right ventricle where partial mixture of the blood took place. The function of the right ventricle was to pump ...
... Changes consistent with those of giant cell arteritis were found in the ascending aorta of a mature male South American monkey, Callimico goeldii. The essential change was necrosis of the tunica media with associated granulomatous inflammatory reaction. There also were compensatory fibroelastic thickening of the tunica intima and lymphocytic-plasmacytic cellular infiltrations of the tunica adventi ...
... Examinaiion of the aortas of 26 goals, 2–10 years old, disclosed various kinds of pathological processes such as melanosis; intimal fat deposits, independent of age, with and without intimal fibrosis; plaque-like intimal fibrosis; calcification of elastic fibers; medial necrosis of the abdominal aorta of the older animals with and without calcification; cartilaginous and osseous metaplasia at the ...
... A chemodectoma of the aortic body was found at the base of heart of a Brahminy duck (Tadorna ferruginea). It incorporated aorta and pulmonary artery at their emergence, part of vagus nerve, sympathetic ganglion, and thyroid gland. The tumor cells had infiltrated the local lymphatics only. ...
... A lamellar unit structure is present throughout the subphylum. From measurements of the change in diameter of the aorta in response to increased pressure, strain values were calculated for the aorta of species of reptiles, birds and mammals. Differences may be relevant to the development of degenerative vascular disease in these orders. ...
... The intimal surface of the aortic arch of 16 of 20 male common brown hares and 10 of 14 females had raised pale yellow to grey-white plaques up to 6 mm in diameter. These lesions were characterised by necrosis and calcification mainly in the tunica media and were not related to the age of the hares. In the hare this vascular disease may develop after injury to the connective tissue during oblitera ...
... When used to restrain rats while obtaining cardiac blood, there was little difference between the effects of ether, pentobarbitone sodium, and fentanyl plus droperidol on acid-base balance, haemoglobin, haematocrit, plasma protein, calcium and magnesium. The use of manual restraint increased blood acidity, plasma protein, calcium and magnesium, but decreased blood glucose. Haemoglobin and haematoc ...
... Two different congenital malformations of the heart were seen in two calves and two ewe lambs. In all these malformations the left ventricle was more or less hypoplastic; it was small with a narrow lumen and a thick wall. In one malformation the aorta began as a cul-de-sac above the left ventricle; in the other, the aorta arose from the right ventricle, to the right of the supraventricular crest. ...
... Transplantation is necessary for evaluation of kidney preservation procedures, and a model using a small laboratory animal is desirable. The rabbit was found to be a suitable animal for this purpose. Even long periods of anaesthesia without artificial respiration were safely achieved. Hydration and serum electrolytes could be maintained within normal ranges with intravenous injections of isotonic ...
... Aortic lesions pathognomonic for Spirocerca lupi were found in 123 of 150 (82%) coyotes. Canis latrans. 23 of 66 (35%) bobcats. Felis rufus, one of five gray foxes, Urocyon cinereoargenteus and one of two red foxes. Vulpes vulpes, examined in West Texas. Adult nematodes in the esophagus were recovered from 11 of 150 (7%) coyotes. In the aorta there was initially an acute inflammatory response foll ...
... A four-month-old toy poodle bitch with growth retardation, coughing, decreased exercise tolerance and cyanotic mucous membranes had a systolic murmur and cardiomegaly. There was severe concentric hypertrophy of the right ventricle and both the aorta and pulmonic trunk originated from the left ventricle. ...
... Vascular obstruction of the hindlimbs was diagnosed clinically in 15 horses, and was characterized at necropsy in eight of those horses. The condition was identified as an incidental post mortem finding in two additional horses. The principal clinical signs in affected horses were progressive exercise intolerance and hind-leg lameness. At post mortem the oldest lesions were located at the aortic q ...
... 130 Male Wistar rats, 2-3 months old and weighing 250-350 g were operated on to implant biodegradable small-calibre vascular prostheses (length 10 mm; internal diameter 1-5 mm) in their infrarenal abdominal aorta. The mean operation time was 40 min, the mean aortic cross-clamping time 25 min. The early patency rate was 100% the late patency rate was 97-7%, and the operative mortality was 3-1%. Mic ...
... Copper deficiency adversely affects the extracellular matrix of the arterial wall, leading to cardiovascular lesions. To study the lesions resulting from copper deficiency, the composition of proteoglycans from aortas of copper-deficient rats was compared with proteoglycans of aortas from copper-supplemented rats. Copper deficiency in rats was verified by copper levels in adrenal glands (mean +/- ...
... The regression of diet-induced atherosclerosis in Güttingen Miniature Swine was investigated after a 6-month induction period. At 1 month after feeding a high-cholesterol and high-fat diet, levels of µ-lipoprotein, total cholesterol, free fatty acids and phospholipid had increased rapidly and the high levels were maintained throughout the 6 month induction period. Morphological features at 6 month ...
... Endothelium-dependent relaxation of aortas was studied in dietary copper (Cu) deficiency. Male, weanling Sprague-Dawley rats were fed diets deficient (CuD, less than 0.5 ppm) or adequate (CuA, 5.0-5.5 ppm) in Cu for 4 weeks. Aortic rings from paired Cu-deficient and Cu-adequate rats were isolated from the descending thoracic aorta, placed in tandem tissue baths, and attached to force transducers. ...
... Salivary vasodilators of Aedes aegypti (L.) and Anopheles albimanus (Wiedemann) were characterized previously as a tachykinin peptide and a catechol oxidase/peroxidase activity, respectively. To verify whether these two different vasodilators also were found in other distantly related members of each mosquito genus, we characterized the vasodilators from A. triseriatus and A. gambiae. A. triseriat ...
... The aortic wall structure of genetically determined hypercholesterolaemic (Yoshida) and control (Brown-Norway) rats was investigated by transmission and scanning electron and light microscopy. Leucocyte adherence mostly at branch sites and irregular protrusive structures were observed on the endothelial surface of the thoracic aorta of Yoshida, but not of Brown-Norway rats. The subendothelial spac ...
... Three lines of Japanese quail males, unselected controls (CL), high response (HL), and low response (LL) lines, selected for plasma total cholesterol for 18 generations, were fed all-plant source, nonatherogenic diets to which 0 or .5% cholesterol were added from 6 to 18 wk of age. Atherosclerotic scores (AS) of aorta of HL birds fed cholesterol were significantly higher than those of LL birds fed ...
... Unique inflammatory lesions affecting the ascending aorta and pulmonary artery of BALB/c and C57BL/6 mice infected with murine cytomegalovirus (MCMV) were identified in a pilot and two subsequent experiments to characterize the potential effect of MCMV infection on diet-induced atherosclerotic lesions. Suckling BALB/c and C57BL/6 mice were inoculated with MCMV and subsequently fed either a commerc ...
... The two heads of porcine aorta smooth muscle myosin can be cross-linked by a disulfide bridge between the two 17-kDa essential light chains with 5,5'-dithiobis(2-nitrobenzoic acid) [Katoh, T., Tanahashi, K., Hasegawa, Y. & Morita, F. (1995) Eur. J. Biochem. 227, 459-465]. When the cross-linked myosin sample was visualized by rotary shadowing, the two heads of myosin molecules appeared predominantl ...
... The effects of dietary 18:3n - 3 on the fatty acid composition of plasma, red blood cells, aorta, platelets, plasma cholesterol, triglycerides, and platelet response to collagen-induced aggregation in swine was investigated. Pigs (n = 25) were fed diets containing 18:3n - 3 at 0% (control), 1.5% (LNA1), 2.5% (LNA2), and 3.6% (LNA3). Dietary 18:3n - 3 resulted in a significant (P < 0.05) enrichment ...
animal fats and oils; corn oil; aorta; dietary supplements; antioxidants
Abstract:
... Objective: To test the hypothesis that dietary fats, depending on the fat source, may modulate aortic lipid peroxidation and antioxidant protection. Methods: Rabbits were fed a low fat (LF, 2 g/100 g corn oil) diet or LF enriched with 16 g/100 g (w/w) of corn oil (CO), corn oil plus cholesterol (23.5 mg/100 g diet, CO+C), bovine milk fat (MF), chicken fat (CF), beef tallow (BT) or lard (L). After ...
... The avian embryo is uniquely amenable to experimental manipulation. The most widely used models are chimeras resulting from heterotopic or orthotopic exchanges of rudiments between chick and quail embryos, according to Le Douarin's technique (1969). Cell migrations and fates are traced in these chimeras either through the identification of quail cell nuclei stained for DNA or by means of monoclona ...
... Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D₂ and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar ...
... The present study was designed to examine the vasorelaxant action of the herbal medicine Catuama and the hydroalcoholic extracts (HE) of each plant present in this product and to compare their effects with that caused by acetylcholine (ACh) in intact (+E) or in endothelium‐rubbed (−E) rings of rat thoracic aorta (RA), guinea‐pig pulmonary artery (GPPA), guinea‐pig mesenteric artery (GPMA), rabbit ...
... An optimized procedure for perfusion of pigs infected with Schistosoma japonicum was developed. The technique involves insertion of a perfusion influx tube into the thoracic descending aorta, clamping vessels to parts of the body which did not need to be perfused (the kidneys, hind legs, etc.) and placing a collection tube directly into the portal vein. In addition, the clamping technique allows f ...
dogs; aorta; heart valves; congenital abnormalities; resection; prostheses; case studies
Abstract:
... A 12monthoid neutered male golden retriever was presented with a history of lethargy and exercise intolerance. Clinical examination, electrocardiography, radiography and echocardiography supported a diagnosis of fixed subvalvular aortic stenosis with a Doppler pressure gradient of 77.5 mmHg. Surgical inspection also revealed gross structural abnormalities of the mitral valve consistent with mitral ...
Cephalopoda; aorta; congenital abnormalities; embryogenesis; heart; mutagens; France
Abstract:
... In semi-adultSepia officinalis L. (Cephalopoda) from the Bay of Arcachon (France) a congenital malformation of the systemic heart is described by macro-and microscopical methods. It concerns an atypical doubling of the site of insertion at the cephalic aorta at the apical ventricle. Its comparison with the paired anlagen of the systemic heart complex in normal embryogenesis and the central circula ...
... A study was undertaken to investigate the relationship between murmur intensity, murmur duration, duration to peak intensity and frequency components with degree of aortic stenosis in boxers. Measurements were made from phonocardiograms obtained from 35 boxers with ejection‐type murmurs, and values were compared with those obtained for aortic flow velocity measured by Doppler echocardiography. Mur ...
... This study was conducted to validate echocardiography in chickens, and to compare cardiac structure and function between broiler and Leghorn chickens. Diameters of the right and left ventricles, and thicknesses of the left ventricular free wall and the interventricular septum were measured echocardiographically in 5- and 7-wk-old chickens from both lines. Images were obtained from minimally restra ...
antibodies; antigens; aorta; blood groups; glycosphingolipids; high performance liquid chromatography; humans; mass spectrometry; nuclear magnetic resonance spectroscopy; swine; thin layer chromatography; xenotransplantation
Abstract:
... Total non-acid glycosphingolipids were isolated from the aortas of more than 80 pigs. The glycolipids were separated by HPLC, analysed by thin-layer chromatography, and tested for reactivity with monoclonal anti-blood group antibodies. The fractions were structurally characterized by NMR spectroscopy and mass spectrometry. Reactivity with both antiblood group A and H antibodies was seen. The major ...
... Plant phenolics present in fruits and vegetables and that are particularly rich in tea and wine have received considerable attention because of their potential antioxidant activity. Two types of commercial green tea from Japan and two active components of green tea, catechin and epicatechin, were assessed for their relative abilities to inhibit the oxidation of low-density lipoprotein (LDL) mediat ...
... Objective—To determine the plasma concentrations and cardiovascular changes that occur in healthy dogs and dogs with aortic stenosis that are given an infusion of lidocaine during isoflurane anesthesia. Study Design—Phase 1, controlled randomized cross‐over trial; Phase 2, before and after trial Animals—Phase 1, 6 healthy dogs (4 female, 2 male) weighing 23.8 ± 7.4 kg; Phase 2, 7 dogs (4 female, 3 ...
... Turkey poults were inoculated at hatch with the "W" isolate of Bordetella avium. At 17 d of age, serum copper levels and ceruloplasmin activities were determined. The trachea and aorta were analyzed for collagen and elastin content in an attempt to relate these structural proteins to the clinical observations of tracheal ring distortion and cardiac dysfunction associated with bordetellosis. Serum ...
... Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors. While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1. In the current study we present evidenc ...
rice bran; atherogenesis; macrophages; cellulose; feces; oat bran; blood plasma; blood lipids; Mesocricetus auratus; body weight; vitamin supplements; aorta; lipid metabolism; excretion; high density lipoprotein; food intake; liver; weight gain; soy protein; experimental diets; vitamin E; very low density lipoprotein; cholesterol; low density lipoprotein
Abstract:
... Four-week-old male golden Syrian hamsters were fed diets containing cellulose (control, CC), cellulose + soy protein (CS), CS + vitamin E, (CSE), rice bran (RB), RB + vitamin E (RBE), oat bran (OB), and OB + vitamin E (OBE) for six weeks (n = 10/treatment). Diets contained (by weight) 10% total dietary fiber, 3% N, 20% fat, 0.5% cholesterol, and some diets had an additional 0.1% vitamin E. After s ...
... Apolipoprotein (apo) E-deficient mice were fed an atherogenic diet with either 1% ethyl ester docosahexaenoic acid (DHA) or safflower oil (SO) as a source of linoleic acid for 8 week. Both genders fed DHA had higher proportions of eicosapentaenoic acid and DHA, and lower proportions of linoleic and arachidonic acids in the liver and serum phospholipids than those fed SO. Males fed DHA had greater ...
cats; aorta; congenital abnormalities; esophagus; trachea (vertebrates); case studies
Abstract:
... A double aortic arch is described in an 8-week-old female Siamese cat. In this case a vascular ring anomaly consistent with a double aortic arch is described in a cat. Stridor and dysphagia were noted in the cat. Radiography showed an esophageal dilation, with constriction at the fifth intercostal space. At necropsy, the esophagus and trachea were constricted at the base of the heart. The cause of ...
... Red wine was given to Watanabe heritable hyperlipidemic (WHHL) rabbits (7 mL/kg/day, approximately 23 mg total polyphenol/kg/day) from the age of 4 months for 14 months. With WHHL rabbits given a comparable dose of alcohol used as references, the effect of wine phenolics on the morphology of atherosclerotic lesions in the coronary artery and aorta was investigated in light of the susceptibility of ...
... Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, l ...
... The clinical case records of 44 cats with distal aortic thromboembolism were reviewed. These detailed 49 separate episodes of thromboembolism. Of the 44 cats, 33 (75%) were neutered males, and 43 (98%) were domestic shorthairs. The mean age was 8.7 years (age range 2–16 years). Evidence of pre-existing heart disease had been noted in 23% of cases. Heart failure was a concurrent diagnosis in 51% of ...
... Adult Atlantic salmon (Salmo salar) were exposed for 48 h to water from acidified (pH 5.2) Fossbekk River (Norway), with and without 94 µg aluminium (Al)/L added as AlCl₃, and to water from circumneutral (pH 6.7) Ims River (Norway) (controls). Cardiac output, heart rate, and stroke volume were monitored throughout the exposure period with Doppler flow probes placed around the ventral aorta of the ...
... A study was carried out to establish an animal model that would be suitable for evaluating the role of the diet in immune cell-mediated atherogenesis. Brown Norway rats were initially treated with hypervitamin D₂ for 4 days and then fed on an atherogenic diet for 3 months, during which period the rats were either immunized with ovalubumin plus Al(OH)₃ (OVA group) or with Al(OH)₃ alone (control gro ...
... Corpora cardiaca of the earwigs Labidura riparia and Forficula auricularia contain a substance that causes hyperlipaemia in migratory locusts and hypertrehalosaemia in the American cockroaches. A conspecific bioassay in L. riparia revealed that this factor is lipid-mobilizing. Isolation of the neuropeptide was achieved by single-step RP-HPLC. The primary structure of the earwig adipokinetic peptid ...
... The effects of dietary ingestion of tomato were studied in mice that had been made hypercholesterolemic by feeding atherogenic diets. Mice which had been fed on the atherogenic diet without tomato for 4 months had significantly increased plasma lipid peroxide, and the vaso-relaxing activity in the aorta induced by acetylcholine (ACh) was harmed when compared with mice fed on a common commercial di ...
... A new technique combining oesophageal intubation, dorsal aorta cannulation, and urinary catheterization was developed to monitor concentration of nutrients in the blood circulation and their metabolites in the urine of 1–2 kg white sturgeon, Acipenser transmontanus. Three experiments were conducted to assess the technique based on: (1) quantitative delivery of nutrients; (2) stress levels post-ope ...
thrombosis; aspirin; prognosis; dogs; case studies; aorta
Abstract:
... Six dogs had signs of pelvic limb weakness, pain and collapse as a result of occlusion of the distal aorta and/or the iliac arteries by a thrombus. Antemortem diagnosis was made on the basis of clinical signs, angiography and ultrasonography. Five dogs had concurrent disease that probably predisposed to thrombosis, including hyperadrenocorticism (three dogs), neoplasia and cardiac disease. Two dog ...
... In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced ...