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You searched for: Author "Rutherford, Mark S." Remove constraint Author: "Rutherford, Mark S." Subject apoptosis Remove constraint Subject: apoptosis Subject Cryptosporidium parvum Remove constraint Subject: Cryptosporidium parvum Subject gene expression Remove constraint Subject: gene expression
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1. Biphasic Modulation of Apoptotic Pathways in Cryptosporidium parvum-Infected Human Intestinal Epithelial Cells

Author:
Rutherford, Mark S.,   et al.   ; Liu, Jin; Deng, Mingqi; Lancto, Cheryl A.; Abrahamsen, Mitchell S.; Enomoto, Shinichiro;     Show all 6 Authors
Source:
Infection and immunity 2009 v.77 no.2 pp. 837-849
ISSN:
0019-9567
Subject:
Cryptosporidium parvum; adenocarcinoma; apoptosis; gene expression; gene expression regulation; genes; humans; intestinal mucosa; meronts; microarray technology; models; transcription (genetics)
Abstract:
... The impact of Cryptosporidium parvum infection on host cell gene expression was investigated by microarray analysis with an in vitro model using human ileocecal HCT-8 adenocarcinoma cells. We found changes in 333 (2.6%) transcripts at at least two of the five (6, 12, 24, 48, and 72 h) postinfection time points. Fifty-one of the regulated genes were associated with apoptosis and were grouped into f ...
DOI:
10.1128/IAI.00955-08
PubMed:
19075026
PubMed Central:
PMC2632021

2. Inhibition of Apoptosis in Cryptosporidium parvum-Infected Intestinal Epithelial Cells Is Dependent on Survivin

Author:
Rutherford, Mark S.,   et al.   ; Liu, Jin; Enomoto, Shinichiro; Lancto, Cheryl A.; Abrahamsen, Mitchell S.;     Show all 5 Authors
Source:
Infection and immunity 2008 v.76 no.8 pp. 3784-3792
ISSN:
0019-9567
Subject:
Cryptosporidium parvum; apoptosis; caspase-2; epithelial cells; gene expression; gene expression regulation; genes; humans; intestinal mucosa; parasites; proteins; ribosomal RNA
Abstract:
... Cryptosporidium parvum is an obligate intracellular protozoan capable of causing severe diarrheal disease in a wide variety of mammals, including humans. C. parvum infection has been associated with induction of apoptosis in exposed epithelial cells, and we now demonstrate that apoptosis is restricted to a subset of cells actively infected with C. parvum. Approximately 20% of the infected cells un ...
DOI:
10.1128/IAI.00308-08
PubMed:
18519556
PubMed Central:
PMC2493198