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You searched for: Author "Liu, Luming" Remove constraint Author: "Liu, Luming" Subject apoptosis Remove constraint Subject: apoptosis Subject blood serum Remove constraint Subject: blood serum
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1. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity

Author:
Liu, Luming,   et al.   ; Li, Pei; Zhou, Guoyu; Tian, Zhiyuan; Luo, Chen; Xia, Tao; Chen, Jingwen; Niu, Qiang; Dong, Lixin; Zhao, Qian; Wang, Aiguo; Zhang, Shun;     Show all 12 Authors
Source:
The Science of the total environment 2018 v.645 pp. 363-371
ISSN:
0048-9697
Subject:
DNA fragmentation; apoptosis; autophagy; blood serum; brain; caspase-12; caspase-3; endoplasmic reticulum; epithelial cells; females; fetus; flame retardants; gene expression regulation; infants; laboratory animals; mechanism of action; neurotoxicity; progeny; rats; triiodothyronine; unfolded protein response; weaning
Abstract:
... Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuses and infants. However, little is known about the effects of PBDE-47 on maternal thyroid status and its mode of action. Here, using female Sprague-Dawley ra ...
DOI:
10.1016/j.scitotenv.2018.07.138

2. Perinatal low-dose PBDE-47 exposure hampered thyroglobulin turnover and induced thyroid cell apoptosis by triggering ER stress and lysosomal destabilization contributing to thyroid toxicity in adult female rats

Author:
Liu, Luming,   et al.   ; Li, Pei; Gao, Hui; Dong, Lixin; Zhou, Guoyu; Luo, Chen; Tian, Zhiyuan; Xia, Tao; Wang, Aiguo; Zhang, Shun;     Show all 10 Authors
Source:
Journal of hazardous materials 2020 v.392 pp. 122265
ISSN:
0304-3894
Subject:
adults; apoptosis; blood serum; breeding; cathepsin B; endoplasmic reticulum; females; homeostasis; laboratory animals; lysosomes; membrane permeability; oral administration; rats; thyroglobulin; thyroid gland; thyroid hormones; toxicity; unfolded protein response; weaning
Abstract:
... Evidence demonstrates that 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47) is able to disturb thyroid hormones (THs) homeostasis, yet the mechanisms remain unknown. We sought to investigate the effects of PBDE-47 on endoplasmic reticulum (ER) and lysosomes in thyroids. Using female Sprague-Dawley rats orally administered PBDE-47 at environmentally relevant doses (0.1, 1.0, 10 mg/kg/day) beginning ten ...
DOI:
10.1016/j.jhazmat.2020.122265