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- Paumann-Page, Martina, et al. Show all 9 Authors
- Archives of biochemistry and biophysics 2018 v.643 pp. 14-23
- aspartic acid; biosynthesis; catalytic activity; chemical bonding; crystal structure; extracellular matrix; glutamic acid; heme; innate immunity; moieties; peroxidase; phylogeny; post-translational modification
- ... Four heme peroxidase superfamilies arose independently in evolution. Only in the peroxidase-cyclooxygenase superfamily the prosthetic group is posttranslationally modified (PTM). As a consequence these peroxidases can form one, two or three covalent bonds between heme substituents and the protein. This may include ester bonds between heme 1- and 5-methyl groups and glutamate and aspartate residues ...