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1. Mediating K⁺/H⁺ Transport on Organelle Membranes to Selectively Eradicate Cancer Stem Cells with a Small Molecule

Author:
Shen, Fang-Fang; Dai, Sheng-Yao; Wong, Nai-Kei; Deng, Shan; Wong, Alice Sze-Tsai; Yang, Dan
Source:
Journal of the American Chemical Society 2020 v.142 no.24 pp. 10769-10779
ISSN:
1520-5126
Subject:
animal ovaries; apoptosis; autophagy; cations; cytotoxicity; homeostasis; membrane potential; mice; mitochondria; neoplasm cells; ovarian neoplasms; pH; potassium; potassium channels; protons; stem cells; transporters
Abstract:
... mitochondrial and lysosomal membranes in living cells. Consequent mitochondrial and ...
DOI:
10.1021/jacs.0c02134

2. Intrinsic lysosomal targeting fluorescent carbon dots with ultrastability for long-term lysosome imaging

Author:
Guo, Shuo; Sun, Yuanqiang; Geng, Xin; Yang, Ran; Xiao, Lehui; Qu, Lingbo; Li, Zhaohui
Source:
Journal of materials chemistry B 2020 v.8 no.4 pp. 736-742
ISSN:
2050-7518
Subject:
apoptosis; autophagy; biocompatibility; carbon quantum dots; drug carriers; drugs; fluorescence; human cell lines; image analysis; lysosomes; microwave radiation; photobleaching; photostability; pyrolysis; toxicology; water solubility
Abstract:
... lysosomes in living cells, but also lysosomes in drug-induced apoptotic cells and fixed ...
DOI:
10.1039/c9tb02043h

3. Polarity-Sensitive Polymer Carbon Dots Prepared at Room-Temperature for Monitoring the Cell Polarity Dynamics during Autophagy

Author:
Liu, Jia Hui; Li, De Yu; He, Jia Hui; Yuan, Dan; Li, Rong Sheng; Zhen, Shu Jun; Li, Yuan Fang; Huang, Cheng Zhi
Source:
ACS applied materials & interfaces 2020 v.12 no.4 pp. 4815-4820
ISSN:
1944-8252
Subject:
ambient temperature; apoptosis; autophagy; biocompatibility; carbon quantum dots; cell polarity; crosslinking; dioxane; dopamine; energy; equipment; fluorescence; hydrogen peroxide; mixing; monitoring; optical properties; photostability; polymerization; polymers; rapamycin; starvation; trehalose
Abstract:
... autophagy has been successfully monitored in living cells. Moreover, the change of ...
DOI:
10.1021/acsami.9b18934

4. Full anti-apoptotic function of Bcl-XL complexed with Beclin-1 verified by live-cell FRET assays

Author:
Wen, Junlin; Mai, Zihao; Zhao, Mengxin; Wang, Xiaoping; Chen, Tongsheng
Source:
Biochemical and biophysical research communications 2019 v.511 no.3 pp. 700-704
ISSN:
0006-291X
Subject:
apoptosis; autophagy; binding sites; energy transfer; fluorescence; staurosporine; stoichiometry
Abstract:
... to quantify the stoichiometry of Bcl-XL-Beclin-1 complex in living cells ...
DOI:
10.1016/j.bbrc.2019.02.107

5. Real-time tracking of the autophagy process in living cells using plasmonically enhanced Raman spectroscopy of fucoidan-coated gold nanoparticles

Author:
JangThese authors contributed equally., Hongje; Kang, Kyungtae; El-Sayed, Mostafa A.
Source:
Journal of materials chemistry 2018 v.6 no.34 pp. 5460-5465
ISSN:
2050-7518
Subject:
Raman spectroscopy; Western blotting; apoptosis; autophagy; bioassays; biopolymers; chemistry; enzyme-linked immunosorbent assay; flow cytometry; fucoidan; humans; matrix-assisted laser desorption-ionization mass spectrometry; nanocomposites; nanogold
Abstract:
... To date, a variety of biological assays such as immunostaining, western blotting, enzyme-linked immunosorbent assay (ELISA), and flow cytometry have been used to analyze and trace important biological events and therapies. In addition to these techniques, the application of microscopic analytical techniques such as matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectro ...
DOI:
10.1039/c8tb01402g

6. Inhibition of ROS production, autophagy or apoptosis signaling reversed the anticancer properties of Antrodia salmonea in triple-negative breast cancer (MDA-MB-231) cells

Author:
Chang, Chia-Ting; Korivi, Mallikarjuna; Huang, Hui-Chi; Thiyagarajan, Varadharajan; Lin, Kai-Yuan; Huang, Pei-Jane; Liu, Jer-Yuh; Hseu, You-Cheng; Yang, Hsin-Ling
Source:
Food and chemical toxicology 2017 v.103 pp. 1-17
ISSN:
0278-6915
Subject:
Antrodia; DNA; DNA fragmentation; acetylcysteine; antineoplastic activity; apoptosis; autophagy; bioluminescence; breast neoplasms; cell viability; culture media; death; humans; image analysis; medicinal fungi; mice; mitochondria; necrosis; signal transduction; toxicology; Taiwan
Abstract:
... inhibited breast tumor growth in living MDA-MB-231-luciferase-injected nude mice. Taken ...
DOI:
10.1016/j.fct.2017.02.019

7. The optimal dose of arsenic trioxide induced opposite efficacy in autophagy between K562 cells and their initiating cells to eradicate human myelogenous leukemia

Author:
Guo, Zhenzhen; Meng, Mingjing; Geng, Shengnan; Du, Zhenhua; Zheng, Yaqiu; Yao, Jingjing; Li, Zibo; Han, Guang; Lin, Haihong; Du, Gangjun
Source:
Journal of ethnopharmacology 2017 v.196 pp. 29-38
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; acridine orange; apoptosis; arsenic; autophagy; blood; cell differentiation; cell proliferation; cell senescence; cytotoxicity; fluorescent antibody technique; humans; immunohistochemistry; leukemia; neoplasm cells; patients; protein synthesis; staining; therapeutics
Abstract:
... examine cell self-renew. ROS generation inside living cells was measured by DCFH-DA. ...
DOI:
10.1016/j.jep.2016.12.010

8. Markers for toxicity to HepG2 exposed to cadmium sulphide quantum dots; damage to mitochondria

Author:
Paesano, Laura; Perotti, Alessio; Buschini, Annamaria; Carubbi, Cecilia; Marmiroli, Marta; Maestri, Elena; Iannotta, Salvatore; Marmiroli, Nelson
Source:
Toxicology 2016 v.374 pp. 18-28
ISSN:
0300-483X
Subject:
apoptosis; autophagy; biomarkers; cadmium; genes; human cell lines; mitochondria; mitochondrial DNA; nuclear genome; occupational exposure; oxidative stress; quantum dots; stress response; sulfides; toxicity; transcription (genetics); transcriptomics
Abstract:
... Interaction of living organisms with quantum dots (QDs) is certainly more ...
DOI:
10.1016/j.tox.2016.11.012

9. Autophagy and apoptosis induced by Chinese giant salamander (Andrias davidianus) iridovirus (CGSIV)

Author:
Du, Jian; Wang, Liqing; Wang, Yuanxian; Shen, Jian; Pan, Chuanyin; Meng, Yan; Yang, Changming; Ji, Hong; Dong, Wuzi
Source:
Veterinary microbiology 2016 v.195 pp. 87-95
ISSN:
0378-1135
Subject:
Andrias; DNA; Iridovirus; apoptosis; autophagy; coat proteins; death; gene expression; immunohistochemistry; kidney cells; kidneys; liver; messenger RNA; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; salamanders and newts; spleen; staining; transmission electron microscopy; viruses
Abstract:
... living CGSs by qPCR. Furthermore, the examinations of autophagy and apoptosis in CGSs ...
DOI:
10.1016/j.vetmic.2016.09.011

10. Stress tolerance in a polyextremophile: the southernmost insect1

Author:
Lee, R.E.; Denlinger, D.L.
Source:
Canadian journal of zoology 2014 v.93 no.9 pp. 679-686
ISSN:
1480-3283
Subject:
adenosine triphosphate; antioxidants; apoptosis; aquaporins; autophagy; catalase; freezing; gene expression regulation; genes; heat shock proteins; hibernation; hypoxia; insect larvae; metabolism; midges; osmotolerance; seawater; stress tolerance; superoxide dismutase; temperate zones; temperature; tissues; Antarctic region
Abstract:
... antarctica Jacobs, 1900), the southernmost free-living insect. Midge larvae can survive ...
DOI:
10.1139/cjz-2014-0147

11. Alternative Cell Death Mechanisms Determine Epidermal Resistance in Incompatible Barley-Ustilago Interactions

Author:
Hof, Alexander; Zechmann, Bernd; Schwammbach, Daniela; Hückelhoven, Ralph; Doehlemann, Gunther
Source:
Molecular plant-microbe interactions 2014 v.27 no.5 pp. 403-414
ISSN:
0894-0282
Subject:
Ustilago segetum; apoptosis; autophagy; barley; genes; host plants; mutants; plant pathogenic fungi; smut diseases
Abstract:
... particularly effective against biotrophic microbes that depend on living host tissue. The ...
DOI:
10.1094/MPMI-10-13-0317-R