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1. MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro‐2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway

Author:
Li, Bing; Huang, Zhi; Meng, Ju; Yu, Wenfeng; Yang, Hua
Source:
Molecular and cellular probes 2020 v.51 pp. 101497
ISSN:
0890-8508
Subject:
animal models; apoptosis; autophagy; blood; brain; brain damage; infarction; microRNA; neurons; rats; stroke
Abstract:
... Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in a variety of biological processes in the nervous system. However, the effects of miR-202-5p on cerebral ischemic stroke injury have not been completely elucidated. In our study, N2a cells were subjected to oxygen-gl ...
DOI:
10.1016/j.mcp.2019.101497

2. Autophagy inhibition changes the disposition of non-viral gene carriers during blood-brain barrier penetration and enhances TRAIL-induced apoptosis in brain metastatic tumor

Author:
Wang, Xuhui; Yin, Sheng; Li, Man; Rao, Jingdong; Wan, Dandan; Qiu, Yue; Yu, Qianwen; Chen, Xiaoxiao; Lu, Zhengze; Long, Yang; Zhang, Zhirong; He, Qin
Source:
Journal of controlled release 2020 v.321 pp. 497-508
ISSN:
0168-3659
Subject:
apoptosis; autophagy; blood-brain barrier; brain; brain neoplasms; breast neoplasms; endothelial cells; gene transfer; genes; human diseases; ligands; lysosomes; metastasis; models; necrosis; polyethyleneimine; signal transduction; therapeutics; tight junctions
Abstract:
... Non-viral gene delivery systems have proven to be a promising approach in the treatment of brain metastatic cancers but facing delivery difficulties. Due to the existence of blood–brain barrier, non-viral gene carriers must pass through brain capillary endothelial cells to accumulate at the brain tumor sites. However, during this process, most of them trap into brain capillary endothelial cells an ...
DOI:
10.1016/j.jconrel.2020.02.042

3. Biglycan protects human neuroblastoma cells from nitric oxide-induced death by inhibiting AMPK-mTOR mediated autophagy and intracellular ROS level

Author:
Chen, Sujuan; Guo, Dandan; Lei, Bingbing; Bi, Jiajia; Yang, Haijie
Source:
Biotechnology letters 2020 v.42 no.4 pp. 657-668
ISSN:
0141-5492
Subject:
Alzheimer disease; Parkinson disease; apoptosis; autophagy; brain; death; humans; metabolism; neurons; neuroprotective effect; neurotoxicity; nitric oxide; nitroprusside; proteoglycans; rapamycin; reactive oxygen species; signal transduction
Abstract:
... The ubiquitous proteoglycan, biglycan (BGN) acts as an important modulator, regulating key molecular pathways of metabolism and brain function. Autophagy is documented as a defining feature of neurodegeneration in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). In the present study, we found that BGN protected neuronal cells from nitric oxide (NO)-induced cell ap ...
DOI:
10.1007/s10529-020-02818-z

4. The effects of Aeromonas hydrophila infection on oxidative stress, nonspecific immunity, autophagy, and apoptosis in the common carp

Author:
Chen, Jianjun; Liu, Nana; Zhang, Huajie; Zhao, Yidi; Cao, Xianglin
Source:
Developmental and comparative immunology 2020 v.105 pp. 103587
ISSN:
0145-305X
Subject:
Aeromonas hydrophila; Cyprinus carpio; Western blotting; apoptosis; autophagy; blood serum; brain; carp; enzyme activity; fish diseases; gene expression regulation; genes; gills; immune response; intestines; kidneys; liver; messenger RNA; oxidative stress; superoxide dismutase; toxicity
Abstract:
... Although the toxicity of Aeromonas hydrophila infection to common carp has been characterized, the mechanisms underlying this toxicity have not been fully explored. The present study assessed the effects of A. hydrophila infection on oxidative stress, nonspecific immunity, autophagy, and apoptosis in the common carp (Cyprinus carpio). We measured the effects of 7.55 × 10⁵ CFU/mL and 4.87 × 10⁷ CFU ...
DOI:
10.1016/j.dci.2019.103587

5. Licochalcone A restrains microphthalmia‐associated transcription factor expression and growth by activating autophagy in melanoma cells via miR‐142‐3p/Rheb/mTOR pathway

Author:
Zhang, Yuhong; Gao, Mingmin; Chen, Li; Zhou, Lijuan; Bian, Shengnan; Lv, Yongmei
Source:
Phytotherapy research 2020 v.34 no.2 pp. 349-358
ISSN:
0951-418X
Subject:
Western blotting; antagonists; antineoplastic activity; apoptosis; autophagy; brain; caspase-3; cell proliferation; enzyme activity; flow cytometry; genes; life cycle assessment; melanin; melanoma; quantitative polymerase chain reaction; rapamycin; therapeutics; toxicity testing; transcription factors
Abstract:
... Licochalcone A (LCA) was found to possess anticancer effects. This study aimed to investigate the anticancer effects and mechanisms of LCA in melanoma. A375 and B16 melanoma cells were stimulated with LCA, MTT assay was used to assess cell proliferation. Expression of miR‐142‐3p, microphthalmia‐associated transcription factor (MITF, which regulates melanin production) and autophagy‐related genes w ...
DOI:
10.1002/ptr.6525

6. Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma

Author:
Fu, Wei; You, Chao; Ma, Lu; Li, Hao; Ju, Yan; Guo, Xi; Shi, Sirong; Zhang, Tao; Zhou, Ronghui; Lin, Yunfeng
Source:
ACS applied materials & interfaces 2019 v.11 no.43 pp. 39525-39533
ISSN:
1944-8252
Subject:
DNA; alkylation agents; apoptosis; autophagy; blood-brain barrier; bone marrow; brain; cell lines; drug resistance; drug therapy; endothelial cells; glioblastoma; mice; nanoparticles; oligonucleotides; prognosis; radiotherapy; resection; transferrin receptors
Abstract:
... Glioblastoma (GBM) is one of the deadliest primary brain malignant tumors with a bleak prognosis. Craniotomy surgical resection followed by radiotherapy and chemotherapy was still the standard therapeutic strategy for GBM. As a target alkylating agent, temozolomide (TMZ) was utilized in the therapy of GBM for decades. However, effective treatment for GBM is stymied by rapid acquired resistance and ...
DOI:
10.1021/acsami.9b13829

7. SQSTM1/p62 is involved in docosahexaenoic acid–induced cellular autophagy in glioblastoma cell lines

Author:
Tan, Xuefeng; Zou, Linqing; Qin, Jianbing; Xia, Donglin; Zhou, Youlang; Jin, Guohua; Jiang, Zhuang; Li, Haoming
Source:
In vitro cellular & developmental biology 2019 v.55 no.9 pp. 703-712
ISSN:
1071-2690
Subject:
antineoplastic agents; apoptosis; autophagy; brain; cell cycle checkpoints; cell lines; docosahexaenoic acid; gene expression regulation; glioblastoma; humans; messenger RNA; neoplasm cells; omega-3 fatty acids; protein synthesis; small interfering RNA; transcription (genetics)
Abstract:
... Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the human brain and works as an anticancer agent to induce cell cycle arrest and apoptosis in glioblastoma multiforme (GBM) cell lines. However, little is known about the connection between DHA and autophagy in GBM cells. We found that high-dose DHA caused cellular autophagy in cultured U251 and U118 GBM cell lines, ...
DOI:
10.1007/s11626-019-00387-8

8. Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway

Author:
Yang, Wei; Tian, Zhi-Kai; Yang, Hui-Xin; Feng, Zhao-Jun; Sun, Jian-Mei; Jiang, Hong; Cheng, Chao; Ming, Qing-Lei; Liu, Chan-Min
Source:
Food and chemical toxicology 2019
ISSN:
0278-6915
Subject:
Toll-like receptor 4; antioxidants; apoptosis; autophagy; brain; calcium; calcium-calmodulin-dependent protein kinase; calmodulin; caspase-3; flavonoids; fruits; interleukin-6; mice; neurodegenerative diseases; neurotoxicity; phosphorylation; protective effect; transcription factor NF-kappa B; tumor necrosis factor-alpha; vegetables
Abstract:
... Fisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the protective effect of fisetin against lead-induced synaptic dysfunction, neuroinflammation and neurodegeneration in mice, and explores its underlying mechanisms. The results indicated fisetin can significantly ameliorated ...
DOI:
10.1016/j.fct.2019.110824

9. PD98059 protects the brain against mitochondrial-mediated apoptosis and autophagy in a cardiac arrest rat model

Author:
Zheng, Jun-Hui; Xie, Lu; Li, Nuo; Fu, Zhao-Yin; Tan, Xiao-Feng; Tao, Ran; Qin, Tao; Chen, Meng-Hua
Source:
Life sciences 2019 v.232 pp. 116618
ISSN:
0024-3205
Subject:
animal models; antioxidants; apoptosis; autophagy; brain; cardiac arrest; cardiopulmonary resuscitation; caspase-3; cytochrome c; dose response; mitochondria; mitogen-activated protein kinase; oxidative stress; permeability; rats; signal transduction; tissues
Abstract:
... Mitochondrial dysfunction has been regarded as one of the hallmarks of cerebral ischemia-reperfusion injury. In previous studies, we have provided evidence that the extracellular signaling pathway (ERK) 1/2 inhibitor PD98059 improved the neurological deficits by modulating antioxidant and anti-apoptotic activities in rats subjected to cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Since ox ...
DOI:
10.1016/j.lfs.2019.116618

10. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway

Author:
Wang, Xiaoke; Zhu, Piaoyu; Xu, Shenya; Liu, Yuting; Jin, Yang; Yu, Shali; Wei, Haiyan; Li, Jinlong; Zhang, Qinglin; Hasegawa, Takahiro; Yao, Chenjuan; Yoshimura, Hiroshi; Wu, Qiyun; Zhao, Xinyuan
Source:
The international journal of biochemistry & cell biology 2019 v.114 pp. 105561
ISSN:
1357-2725
Subject:
acetylcysteine; air; antimony; antioxidants; apoptosis; autophagy; brain; death; dose response; drinking water; fluorescence; humans; mice; nerve tissue; neurons; neurotoxicity; non-specific serine/threonine protein kinase; oxygen; phosphorylation; potassium; rapamycin
Abstract:
... Antimony (Sb), a naturally occurring metal present in air and drinking water, has been found in the human brain, and there is evidence of its toxic effects on neurobehavioral perturbations, suggesting that Sb is a potential nerve poison. Here, we provide the first study on the molecular mechanism underlying Sb-associated neurotoxicity. Mice exposed to antimony potassium tartrate hydrate showed sig ...
DOI:
10.1016/j.biocel.2019.105561

11. The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas

Author:
Lu, Lu; Shen, Xinkun; Tao, Bailong; Lin, Chuanchuan; Li, Ke; Luo, Zhong; Cai, Kaiyong
Source:
Journal of materials chemistry B 2019 v.7 no.12 pp. 2054-2062
ISSN:
2050-7518
Subject:
albumins; antineoplastic agents; apoptosis; autophagy; blood-brain barrier; brain; chemistry; chloroquine; drug therapy; energy; folic acid; genes; glioblastoma; metabolism; nanoparticles; neoplasm cells; paclitaxel; stem cells; transporters
Abstract:
... Due to the rapid growth of a tumor, the tumor cell metabolism becomes more active, resulting in the overexpression of albumin-binding proteins for transporting albumin as an energy and amino source. In that case, making use of nutrient transporters for targeted drug delivery to the brain becomes attractive. Herein, we synthesized albumin nanoparticles by a desolvation process, modified them with f ...
DOI:
10.1039/c8tb03165g

12. European sea bass brain DLB-1 cell line is susceptible to nodavirus: A transcriptomic study

Author:
Chaves-Pozo, Elena; Bandín, Isabel; Olveira, José G.; Esteve-Codina, Anna; Gómez-Garrido, Jèssica; Dabad, Marc; Alioto, Tyler; Ángeles Esteban, M.; Cuesta, Alberto
Source:
Fish & shellfish immunology 2019 v.86 pp. 14-24
ISSN:
1050-4648
Subject:
Betanodavirus; Dicentrarchus labrax; apoptosis; autophagy; bass; brain; cell lines; cytopathogenicity; encephalopathy; financial economics; gene expression regulation; genes; genotype; heat shock proteins; immune response; interferons; mariculture; mortality; neurons; proteasome endopeptidase complex; retinal diseases; sequence analysis; transcription (genetics); transcriptomics
Abstract:
... Viral diseases are responsible for high rates of mortality and subsequent economic losses in modern aquaculture. The nervous necrosis virus (NNV) produces viral encephalopathy and retinopathy (VER), which affects the fish central nervous system. It is considered one of the most serious viral diseases in marine aquaculture, the European sea bass (Dicentrarchus labrax) being amongst the most suscept ...
DOI:
10.1016/j.fsi.2018.11.024

13. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity

Author:
Li, Pei; Liu, Luming; Zhou, Guoyu; Tian, Zhiyuan; Luo, Chen; Xia, Tao; Chen, Jingwen; Niu, Qiang; Dong, Lixin; Zhao, Qian; Wang, Aiguo; Zhang, Shun
Source:
The Science of the total environment 2018 v.645 pp. 363-371
ISSN:
0048-9697
Subject:
DNA fragmentation; apoptosis; autophagy; blood serum; brain; caspase-12; caspase-3; endoplasmic reticulum; epithelial cells; females; fetus; flame retardants; gene expression regulation; infants; laboratory animals; mechanism of action; neurotoxicity; progeny; rats; triiodothyronine; unfolded protein response; weaning
Abstract:
... Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuses and infants. However, little is known about the effects of PBDE-47 on maternal thyroid status and its mode of action. Here, using female Sprague-Dawley ra ...
DOI:
10.1016/j.scitotenv.2018.07.138

14. Fluorescent magnetic PEI-PLGA nanoparticles loaded with paclitaxel for concurrent cell imaging, enhanced apoptosis and autophagy in human brain cancer

Author:
Wang, Xueqin; Yang, Liping; Zhang, Huiru; Tian, Baoming; Li, Ruifang; Hou, Xuandi; Wei, Fang
Source:
Colloids and surfaces 2018 v.172 pp. 708-717
ISSN:
0927-7765
Subject:
adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; brain; brain neoplasms; cell proliferation; colloids; drug carriers; ferric oxide; fluorescein; fluorescence; glioblastoma; humans; image analysis; isothiocyanates; maghemite; magnetism; nanoparticles; paclitaxel; polyethyleneimine
Abstract:
... Magnetic nanoparticles are regarded as a promising drug delivery vehicle with the improved efficacy and lowered side effects for antitumor therapy. Herein, the poly lactic-co-glycolic acid (PLGA) modified magnetic nanoplatform was synthesized using superparamagnetic γ-Fe₂O₃ nanoparticles (MNPs) as a core, and then labelled with polyethylenimine (PEI)-conjugated fluorescein isothiocyanate (FITC), a ...
DOI:
10.1016/j.colsurfb.2018.09.033

15. Recombinant human brain natriuretic peptide regulates PI3K/AKT/mTOR pathway through lncRNA EGOT to attenuate hypoxia-induced injury in H9c2 cardiomyocytes

Author:
Zhang, Chengxi; Pan, Sinian; Aisha, Ayipaxa; Abudoukelimu, Minawaer; Tang, Leile; Ling, Yesheng
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1186-1193
ISSN:
0006-291X
Subject:
apoptosis; autophagy; brain; cardiomyocytes; cell viability; cyclins; heart failure; humans; hypoxia; natriuretic peptides; normoxia; oxygen; protective effect
Abstract:
... This study aimed to investigate whether recombinant human brain natriuretic peptide (rhBNP) regulated hypoxia-induced injury in H9c2 cardiomyocytes through lncRNA EGOT. H9c2 cardiomyocytes were cultured under normoxia and hypoxia (21% and 3% O₂) conditions, and whether hypoxia induced injury by assessing cell viability, apoptosis and autophagy. H9c2 cells were then treated with different doses of ...
DOI:
10.1016/j.bbrc.2018.07.023

16. Insights into the pathogenesis of herpes simplex encephalitis from mouse models

Author:
Mancini, Mathieu; Vidal, Silvia M.
Source:
Mammalian genome 2018 v.29 no.7-8 pp. 425-445
ISSN:
0938-8990
Subject:
Herpesviridae; animal models; apoptosis; autophagy; brain; carrier state; complications (disease); defense mechanisms; disease severity; encephalitis; genome; herpes simplex; host-pathogen relationships; humans; immunopathology; mice; mucosa; neurons; pathogenesis; patients; virus replication; viruses
Abstract:
... A majority of the world population is infected with herpes simplex viruses (HSV; human herpesvirus types 1 and 2). These viruses, perhaps best known for their manifestation in the genital or oral mucosa, can also cause herpes simplex encephalitis, a severe and often fatal disease of the central nervous system. Antiviral therapies for HSV are only partially effective since the virus can establish l ...
DOI:
10.1007/s00335-018-9772-5
PubMed:
30167845
PubMed Central:
PMC6132704

17. Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades

Author:
Saha, Sukanya; Sadhukhan, Pritam; Mahalanobish, Sushweta; Dutta, Sayanta; Sil, Parames C.
Source:
The Journal of nutritional biochemistry 2018 v.55 pp. 26-40
ISSN:
0955-2863
Subject:
adults; apoptosis; arsenic; autophagy; brain; brain damage; cytotoxicity; energy requirements; genistein; histopathology; intraperitoneal injection; lipid content; membrane potential; mice; mitochondria; mitochondrial membrane; models; neuroprotective effect; oral administration; oxidative stress; rats; tumor necrosis factor-alpha
Abstract:
... Brain is highly prone to oxidative damage due to its huge lipid content and extensive energy requirements. Exogenous insult in brain via oxidative injury can lead to severe pathophysiological conditions. Age-dependent deterioration of normal brain functions is also noteworthy. Genistein, a polyphenolic isoflavonoid, obtained from the soy plant, is well known to protect against several diseased con ...
DOI:
10.1016/j.jnutbio.2017.11.010

18. Versatility of microglial bioenergetic machinery under starving conditions

Author:
Nagy, Adam M.; Fekete, Rebeka; Horvath, Gergo; Koncsos, Gabor; Kriston, Csilla; Sebestyen, Anna; Giricz, Zoltan; Kornyei, Zsuzsanna; Madarasz, Emilia; Tretter, Laszlo
Source:
Biochimica et biophysica acta 2018 v.1859 no.3 pp. 201-214
ISSN:
0005-2728
Subject:
adenosine diphosphate; adenosine triphosphate; aerobiosis; apoptosis; autophagy; biochemical pathways; brain; cell viability; energy; functional diversity; glucose; glutamine; glycolysis; ketone bodies; lactic acid; neuroglia; nutrient availability; nutrients; oxidation; oxygen consumption; phenotype; phosphorylation; pyruvic acid
Abstract:
... Microglia are highly dynamic cells in the brain. Their functional diversity and phenotypic versatility brought microglial energy metabolism into the focus of research. Although it is known that microenvironmental cues shape microglial phenotype, their bioenergetic response to local nutrient availability remains unclear.In the present study effects of energy substrates on the oxidative and glycolyt ...
DOI:
10.1016/j.bbabio.2017.12.002

19. Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection

Author:
Mengying, Zhang; Yiyue, Xu; Tong, Pan; Yue, Hu; Limpanont, Yanin; Ping, Huang; Okanurak, Kamolnetr; Yanqi, Wu; Dekumyoy, Paron; Hongli, Zhou; Watthanakulpanich, Dorn; Zhongdao, Wu; Zhi, Wang; Zhiyue, Lv
Source:
Parasites & vectors 2017 v.10 no.1 pp. 611
ISSN:
1756-3305
Subject:
Parastrongylus cantonensis; Western blotting; apoptosis; astrocytes; autophagy; brain; caspase-3; caspase-4; caspase-6; cognition; flow cytometry; genes; hosts; humans; immunohistochemistry; inflammation; larvae; memory; meninges; meningoencephalitis; messenger RNA; mice; necroptosis; neurons; parasites; pathogenesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; staining; tissues; transcription (genetics); translation (genetics); transmission electron microscopy
Abstract:
... BACKGROUND: Angiostrongylus cantonensis has been the only parasite among Angiostrongylidae to cause human central nervous system infection characterized by eosinophilic meningitis or meningoencephalitis. The mechanism of the extensive neurological impairments of hosts caused by A. cantonensis larvae remains unclear. The aim of the present study was to investigate apoptosis, necroptosis and autopha ...
DOI:
10.1186/s13071-017-2565-y
PubMed:
29258580
PubMed Central:
PMC5735806

20. Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study

Author:
Corsetti, Giovanni; Romano, Claudia; Stacchiotti, Alessandra; Pasini, Evasio; Dioguardi, Francesco S
Source:
Biological trace element research 2017 v.178 no.1 pp. 86-97
ISSN:
0163-4984
Subject:
acetates; anemia; apoptosis; autophagy; blood; brain; calcium; caspase-3; drinking water; endoplasmic reticulum; endoplasmic reticulum stress; exposure duration; feces; heavy metals; histopathology; immunoglobulins; immunotoxicity; iron; kidneys; lead; lead poisoning; liver; macrophage activation; macrophages; megakaryocytes; mice; oxidants; oxidative stress; protein folding; pulp; spleen; splenocytes; superoxide dismutase
Abstract:
... Lead (Pb) is an environmental oncogenic metal that induces immunotoxicity and anaemia. Emerging evidence has linked Pb toxicity with endoplasmic reticulum-driven apoptosis and autophagy. Glucose-regulated protein of 78 kDa (Grp78 or binding immunoglobulin protein (BiP)), a master endoplasmic reticulum chaperone, drives macrophage activation and regulates protein folding and calcium flux in respons ...
DOI:
10.1007/s12011-016-0912-z

21. Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

Author:
Singh, Sandeep; Singh, Abhishek Kumar; Garg, Geetika; Rizvi, Syed Ibrahim
Source:
Life sciences 2017
ISSN:
0024-3205
Subject:
antioxidants; apoptosis; autophagy; brain; galactose; gene expression; genes; genetic markers; interleukin-1beta; low calorie diet; membrane potential; mitochondrial membrane; models; neurodegenerative diseases; neurons; neuroprotective effect; oxidative stress; rats; reverse transcriptase polymerase chain reaction; transporters; tumor necrosis factor-alpha
Abstract:
... In the present study, attempts have been made to evaluate the potential role of fisetin, a caloric restriction mimetic (CRM), for neuroprotection in D-galactose (D-gal) induced accelerated and natural aging models of rat.Fisetin was supplemented (15mg/kg b.w., orally) to young, D-gal induced aged (D-gal 500mg/kg b.w subcutaneously) and naturally aged rats for 6weeks. Standard protocols were employ ...
DOI:
10.1016/j.lfs.2017.11.004

22. Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo

Author:
Hung, Kai-Chih; Huang, Hui-Ju; Wang, Yi-Ting; Lin, Anya Maan-Yuh
Source:
Journal of ethnopharmacology 2016 v.194 pp. 522-529
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Parkinson disease; Scutellaria baicalensis; Western blotting; anti-inflammatory activity; apoptosis; autophagy; biomarkers; brain; caspase-1; cathepsin B; cold; cysteine; dopamine; electrochemistry; enzyme-linked immunosorbent assay; flavonoids; high performance liquid chromatography; in vivo studies; interleukin-1beta; intraperitoneal injection; neuroglia; neurons; neurotoxins; oxidative stress; pathophysiology; rats; staining; tyrosine 3-monooxygenase
Abstract:
... Neuroinflammation, oxidative stress, and protein aggregation form a vicious cycle in the pathophysiology of Parkinson's disease (PD); activated microglia is the main location of neuroinflammation. A Chinese medicine book, “Shanghan Lun”, known as the “Treatises on Cold damage Diseases” has suggested that Scutellaria baicalensis Georgi is effective in treating CNS diseases. The anti-inflammatory me ...
DOI:
10.1016/j.jep.2016.10.040

23. HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: The role of AMP-activated protein kinase

Author:
Xue, Huan; Ji, Yingshi; Wei, Shengnan; Yu, Yang; Yan, Xin; Liu, Shuping; Zhang, Ming; Yao, Fan; Lan, Xiaoxin; Chen, Li
Source:
Life sciences 2016 v.153 pp. 23-34
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; animal disease models; apoptosis; autophagy; berberine; bioavailability; brain; diabetes; glucose; mice; neurons; neurotoxicity; protective effect; signal transduction
Abstract:
... Berberine (BBR) holds promising effect for neuronal injury in diabetes because its anti-apoptotic activity and our laboratory developed the Huang-Gui Solid Dispersion (HGSD) to improve oral bioavailability of BBR. However, anti-apoptotic effect and the mechanism of HGSD in the brain of diabetic mice are not clear. We hypothesized that the AMPK/mTOR signaling pathway could exert a protective role i ...
DOI:
10.1016/j.lfs.2016.04.004

24. The Role of Apoptosis and Autophagy in Bovine Abortions Associated with Brucella Spp

Author:
Ozkaraca, Mustafa; Ceribasi, Songul; Ceribasi, Ali Osman; Kilic, Ayse; Ongor, Hasan
Source:
Acta veterinaria 2016 v.66 no.1 pp. 37-50
ISSN:
1820-7448
Subject:
Brucella; abortion (animals); antibodies; apoptosis; autophagy; bacterial antigens; bovine brucellosis; brain; caspase-3; cattle; fetus; heart; immunohistochemistry; kidneys; liver; lymph nodes; microtubules; muscles; polymerase chain reaction; skeletal muscle; spleen; staining; thymus gland; tissue distribution
Abstract:
... This study is aimed to evaluate the relationship between the severity of apoptotic and autophagic cell death based on the distribution of Brucella spp. antigens in the lung, liver, kidney, spleen, brain, heart, skeletal muscle, mesenteric lymph node, and thymus tissue from bovine fetuses aborted due to natural infection with Brucella spp. The distribution of Brucella spp. antigens was immunohistoc ...
DOI:
10.1515/acve-2016-0003

25. Molecular characterization of Beclin 1 in rare minnow (Gobiocypris rarus) and its expression after waterborne cadmium exposure

Author:
Liu, Xiao-Hong; Wang, Zhi-Jian; Chen, Dong-Ming; Chen, Mu-Fei; Jin, Xing-Xing; Huang, Jing; Zhang, Yao-Guang
Source:
Fish physiology and biochemistry 2016 v.42 no.1 pp. 111-123
ISSN:
0920-1742
Subject:
Gobiocypris rarus; amino acids; apoptosis; autophagy; brain; cadmium; dose response; eggs; exposure duration; females; gene expression regulation; gills; hepatopancreas; larvae; males; messenger RNA; minnows; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
Abstract:
... Beclin 1 plays an important role in autophagy and apoptosis which are well documented in mammals. However, relevant reports are rare in fish. This study characterized Beclin 1 of the rare minnow Gobiocypris rarus (rmBeclin 1), which encodes a peptide of 447 amino acids using RT-PCR and RACE. The deduced peptide showed 96.4 and 80.8 % similarity to Beclin 1 of common carp and human, respectively. S ...
DOI:
10.1007/s10695-015-0122-1

26. Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus

Author:
Ueda, Yutaka; Wei, Fan-Yan; Hide, Taku-ichiro; Michiue, Hiroyuki; Takayama, Kentaro; Kaitsuka, Taku; Nakamura, Hideo; Makino, Keishi; Kuratsu, Jun-ichi; Futaki, Shiroh; Tomizawa, Kazuhito
Source:
Biomaterials 2012 v.33 no.35 pp. 9061-9069
ISSN:
0142-9612
Subject:
apoptosis; autophagy; brain; cell growth; drug therapy; embryonic stem cells; humans; methodology; mice; peptides; regrowth
Abstract:
... Glioblastoma multiforme (GBM) is the most aggressive and fatal brain tumor. GBM is resistant to chemotherapy and radiation. Recent studies have shown that glioma-initiating cells (GICs), which have characteristics of cancer stem cells, are responsible for the resistance to chemotherapy and radiation and regrowth. No effective therapy for GICs has been developed. Here we showed that d-isomer peptid ...
DOI:
10.1016/j.biomaterials.2012.09.003

27. p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

Author:
Vaseva, Angelina V.; Marchenko, Natalie D.; Ji, Kyungmin; Tsirka, Stella E.; Holzmann, Sonja; Moll, Ute M.
Source:
Cell 2012 v.149 no.7 pp. 1536-1548
ISSN:
0092-8674
Subject:
apoptosis; autophagy; brain; cyclophilins; cyclosporine; ischemia; mice; necrosis; oxidative stress; permeability; stroke
Abstract:
... Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell death. Whether p53 can also activate oxidative stress-induced necrosis is, however, ...
DOI:
10.1016/j.cell.2012.05.014
PubMed:
22726440
PubMed Central:
PMC3383624

28. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Author:
Dixon, Scott J.; Lemberg, Kathryn M.; Lamprecht, Michael R.; Skouta, Rachid; Zaitsev, Eleina M.; Gleason, Caroline E.; Patel, Darpan N.; Bauer, Andras J.; Cantley, Alexandra M.; Yang, Wan Seok; Morrison, Barclay, III; Stockwell, Brent R.
Source:
Cell 2012 v.149 no.5 pp. 1060-1072
ISSN:
0092-8674
Subject:
antioxidants; antiporters; apoptosis; autophagy; brain; cystine; death; glutamic acid; iron; necrosis; neoplasm cells; neurodegenerative diseases; rats
Abstract:
... Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemicall ...
DOI:
10.1016/j.cell.2012.03.042
PubMed:
22632970
PubMed Central:
PMC3367386