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1. 3D modelling of the pathogenic Leptospira protein LipL32: a bioinformatics approach

Author:
Sharmilah Kumari Kumaran; Mohd. Faizal Abu Bakar; Hirzahida Mohd-Padil; Shuhaila Mat-Sharani; S. Sakinah; Poorani K; Hiba Alsaeedy; Amira Peli; Teh Seoh Wei; Mok Pooi Ling; Rukman Awang Hamat; Vasantha Kumari Neela; Akon Higuchi; Abdullah A. Alarfaj; Mariappan Rajan; Giovanni Benelli; Palanisamy Arulselvan; S. Suresh Kumar
Source:
Acta tropica 2017 pp. -
ISSN:
0001-706X
Subject:
Leptospira; bacterial antigens; bacterial proteins; bioinformatics; genes; germplasm conservation; hydrophilicity; hydrophobicity; leptospirosis; lipoproteins; models; outer membrane proteins; protein secondary structure; protein tertiary structure; signal peptide; virulent strains; zoonoses
Abstract:
... Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species (Leptospiraceae). LipL32 is a highly abundant lipoprotein from the outer membrane proteins (OMPs) group, which highly conserved among pathogenic and intermediate Leptospira species. Several studies used LipL32 as a specific gene to identify the presence of leptospires. This research was aimed to study on the cha ...
DOI:
10.1016/j.actatropica.2017.09.011

2. Absence of serological or molecular evidence of Leptospira infection in farmed swine in the Hong Kong Special Administrative Region

Author:
Kate J. Flay; Dan A. Yang; Michael T. Wilson; Song H. Lee; Vidya Bhardwaj; Fraser I. Hill; Dirk U. Pfeiffer
Source:
One health 2021 v.13 pp. 100321
ISSN:
2352-7714
Subject:
Leptospira; agglutination tests; bacterial antigens; cross-sectional studies; disease prevalence; kidneys; leptospirosis; piglets; polymerase chain reaction; seroconversion; sows; weanlings; China
Abstract:
... Leptospirosis is an important zoonotic disease with several maintenance host species including swine. A cross sectional survey was undertaken between January to October 2020 to investigate the prevalence of leptospirosis in farmed swine in the Hong Kong Special Administrative Region (HKSAR) of China. Serum samples were collected from swine on seven farms (15 swine per farm; ten multiparous sows an ...
DOI:
10.1016/j.onehlt.2021.100321

3. Action of Polymyxin B on Bacterial Membranes, I. Binding to the O-Antigenic Lipopolysaccharide of Salmonella typhimurium

Author:
J. Bader; M. Teuber
Source:
Zeitschrift für Naturforschung 2014 v.28 no.7-8 pp. 425-433
ISSN:
0939-5075
Subject:
Salmonella Typhimurium; bacterial antigens; binding properties; binding sites; cetylpyridinium chloride; chemotypes; detergents; fluorescence; hydrophobic bonding; lipid A; molecular weight; mutants; pH; permeability; plasma membrane; polymyxin B; sodium chloride
Abstract:
... Polymyxin B (PX) forms complexes with the O-antigenic lipopolysaccharide (LPS) of Salmonella typhimurium which are stable in aqueous 0.14 ᴍ sodium chloride at neutral pH. PX can be quantitatively recovered from the complex by changing the pH from 7 to 1, or by treatment with the cationic detergent cetylpyridinium chloride. This proves that complex formation does not involve covalent linkages, but ...
DOI:
10.1515/znc-1973-7-811

4. Acute Aeromonas salmonicida infection in turbot (Scophthalmus maximus L.). Histopathological and immunohistochemical studies

Author:
Germán Alberto Coscelli; Roberto Bermúdez; Ana Paula Losada; Luis Daniel Faílde; Ysabel Santos; María Isabel Quiroga
Source:
Aquaculture 2014 v.430 pp. 79-85
ISSN:
0044-8486
Subject:
Aeromonas salmonicida subsp. salmonicida; Scophthalmus maximus; bacteremia; bacteria; bacterial antigens; blood vessels; cytoplasm; disease diagnosis; fish culture; histopathology; immunohistochemistry; macrophages; monocytes; necrosis; pathogenesis; phagocytosis; tissues; turbot
Abstract:
... Aeromonas salmonicida subsp. salmonicida (A. salmonicida) is a highly pathogenic bacterium for turbot culture, which represents a great threat in fish farming. In this study, gross and histological lesions in turbot experimentally inoculated with A. salmonicida were analysed. In addition, the distribution of the bacterial antigen in tissues was investigated by using an immunohistochemical method s ...
DOI:
10.1016/j.aquaculture.2014.04.002

5. Additions of Killed Whole Cell Bacteria Preparations to Freund Complete Adjuvant Alter Laying Hen Antibody Response to Soluble Protein Antigen

Author:
Trott, D.L.; Hellestad, E.M.; Yang, M.; Cook, M.E.
Source:
Poultry science 2008 v.87 no.5 pp. 912-917
ISSN:
0032-5791
Subject:
laying hens; antibody formation; inactivated vaccines; disease prevention; maternal immunity; poultry diseases; bacteriocins; vaccine adjuvants; bacterial antigens; egg yolk; vaccination; vaccine development; Mycobacterium; eggs; bacterial infections; microbial genetic resources
Abstract:
... Passive transfer of antibodies from hen to egg has value to both the producer of commercial polyclonal egg antibody and the producer of hatching eggs. Water-in-oil emulsions are commonly amended with immune stimulants such as Mycobacteria (e.g., Freund complete adjuvant; FCA) to increase antibody production to soluble protein antigens (SPA). Recent discoveries of the mechanisms by which microbial ...
DOI:
10.3382/ps.2007-00481

6. The Ag85B protein of the BCG vaccine facilitates macrophage uptake but is dispensable for protection against aerosol Mycobacterium tuberculosis infection

Author:
Kelly A. Prendergast; Claudio Counoupas; Lisa Leotta; Carolina Eto; Wilbert Bitter; Nathalie Winter; James A. Triccas
Source:
Vaccine 2016 v.34 no.23 pp. 2608-2615
ISSN:
0264-410X
Subject:
BCG vaccine; CD8-positive T-lymphocytes; Mycobacterium tuberculosis; aerosols; bacterial antigens; clinical trials; humans; immunity; lungs; macrophages; mice; tuberculosis; vaccination; virulence
Abstract:
... Defining the function and protective capacity of mycobacterial antigens is crucial for progression of tuberculosis (TB) vaccine candidates to clinical trials. The Ag85B protein is expressed by all pathogenic mycobacteria and is a component of multiple TB vaccines under evaluation in humans. In this report we examined the role of the BCG Ag85B protein in host cell interaction and vaccine-induced pr ...
DOI:
10.1016/j.vaccine.2016.03.089

7. Age-dependent seroprevalence of antibodies against a Helicobacter pylori-like organism and Helicobacter pylori in commercially reared swine

Author:
Ellis, J.A.; Waldner, C.L.; McIntosh, K.A.; Rhodes, C.; Harding, J.C.; Ringler, S.S.; Krakowka, S.
Source:
American journal of veterinary research 2006 v.67 no.11 pp. 1890-1894
ISSN:
0002-9645
Subject:
swine; Helicobacter pylori; animal pathogenic bacteria; swine diseases; digestive system diseases; bacterial infections; seroprevalence; animal age; antibodies; bacterial antigens; seroconversion
DOI:
10.2460/ajvr.67.11.1890
PubMed:
17078751

8. Agrobacterium-mediated transformation of lettuce (Lactuca sativa L.) with genes coding bacterial antigens from Mycobacterium tuberculosis

Author:
Matvieieva, N. A.; Vasylenko, M. Yu.; Shakhovsky, A. M.; Kuchuk, N. V.
Source:
Cytology and genetics 2009 v.43 no.2 pp. 94-98
ISSN:
0095-4527
Subject:
DNA; Lactuca sativa; Mycobacterium tuberculosis; bacterial antigens; genes; kanamycin kinase; leaves; lettuce; polymerase chain reaction; seedlings
Abstract:
... Transgenic lettuce plants (Lactuca sativa L.) with genes coding the synthesis of tuberculous antigens were obtained using the Agrobacterium-mediated transformation procedure. Cotyledonary leaves of in vitro lettuce seedlings (cvs. Eralash, Snezhinka, and Rubinovoe Kruzhevo) were transformed with plasmids containing nptII, a selective neomycin phosphotransferase II gene, and ESAT6, Ag85B (-TMD), an ...
DOI:
10.3103/S0095452709020042

9. Alternative vaccination against equine botulism (BoNT/C)

Author:
Frey, J.; Eberle, S.; Stahl, C.; Mazuet, C.; Popoff, M.; Schatzmann, E.; Gerber, V.; Dungu, B.; Straub, R.
Source:
Equine veterinary journal 2007 v.39 no.6 pp. 516-520
ISSN:
0425-1644
Subject:
botulinum toxin; disease prevention; antibodies; adverse effects; bacterial antigens; recombinant vaccines; vaccination; immune response; horse diseases; horses; botulism
PubMed:
18065309

10. Aluminum (oxy) Hydroxide Nanorods Activate an Early Immune Response in Pseudomonas aeruginosa Vaccine

Author:
Yingli Chen; Feng Yang; Jun Yang; Yali Hou; Leilei He; Houxiang Hu; Fenglin Lv
Source:
ACS applied materials & interfaces 2018 v.10 no.50 pp. 43533-43542
ISSN:
1944-8252
Subject:
Pseudomonas aeruginosa; aluminum; antigen-antibody reactions; bacterial antigens; bacterial vaccines; cell-mediated immunity; immunization; immunoglobulin G; infectious diseases; inflammation; nanorods; vaccine adjuvants; veterinary medicine
Abstract:
... Bacterial vaccines have been widely used to prevent infectious diseases, especially in veterinary medicine. Although there are many reports on bacterin adjuvants, only a few contain innovations in bacterin adjuvants. Taking this into consideration, in this study we designed and synthesized a new aluminum (oxy) hydroxide (AlOOH) nanorod (Al-NR) with a diameter of 200 ± 80 nm and a length of 1.1 ± 0 ...
DOI:
10.1021/acsami.8b18164

11. Analysis of the Immune Response to Mycobacterium avium subsp. paratuberculosis in Experimentally Infected Calves

Author:
Koo, Hye Cheong; Park, Yong Ho; Hamilton, Mary Jo; Barrington, George M.; Davies, Christopher J.; Kim, Jong Bae; Dahl, John L.; Waters, W. Ray; Davis, William C.
Source:
Infection and immunity 2004 v.72 no.12 pp. 6870-6883
ISSN:
1098-5522
Subject:
paratuberculosis; bacterial antigens; immune response; CD4-positive T-lymphocytes; calves; lymphocyte proliferation; Mycobacterium avium subsp. paratuberculosis
Abstract:
... Johne's disease of cattle is widespread and causes significant economic loss to producers. Control has been hindered by limited understanding of the immune response to the causative agent, Mycobacterium avium subsp. paratuberculosis, and lack of an effective vaccine and sensitive specific diagnostic assays. The present study was conducted to gain insight into factors affecting the immune response ...
Handle:
10113/40854
DOI:
10.1128/IAI.72.12.6870-6883.2004
PubMed:
15557608
PubMed Central:
PMC529129

12. Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

Author:
Karine M. De Amicis; Samar Freschi de Barros; Raquel E. Alencar; Edilberto Postól; Carlo de Oliveira Martins; Helen Andrade Arcuri; Cibelly Goulart; Jorge Kalil; Luiza Guilherme
Source:
Vaccine 2014 v.32 no.32 pp. 4104-4110
ISSN:
0264-410X
Subject:
Streptococcus pyogenes; antibodies; bacterial antigens; complications (disease); heart; humans; immunization; mice; neutralization; pharyngitis; septic shock; vaccines; Brazil
Abstract:
... Streptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodie ...
DOI:
10.1016/j.vaccine.2013.08.043

13. Analysis of the immunoproteome of Mycoplasma mycoides subsp. mycoides small colony type reveals immunogenic homologues to other known virulence traits in related Mycoplasma species

Author:
Jores, Joerg; Meens, Jochen; Buettner, Falk F.R.; Linz, Bodo; Naessens, Jan; Gerlach, Gerald F.
Source:
Veterinary immunology and immunopathology 2009 v.131 no.3-4 pp. 238-245
ISSN:
0165-2427
Subject:
interspecific variation; immunoblotting; proteome; contagious bovine pleuropneumonia; two-dimensional gel electrophoresis; Mycoplasma mycoides subsp. mycoides LC; polyacrylamide gel electrophoresis; cattle; mycoplasmosis; Mycoplasma mycoides subsp. mycoides SC; bacterial antigens; mass spectrometry; bacterial proteins; Mycoplasma capricolum subsp. capricolum; vaccine development; proteomics; virulence; Mycoplasma agalactiae
Abstract:
... Contagious bovine pleuropneumonia (CBPP) caused by Mycoplasma mycoides subsp. mycoides small colony type (MmmSC) has been eradicated in the developed world, but it is still present in many countries of sub-Saharan Africa. After initially successful control measures in the 1960s it has been spreading due to a lack of money, fragmentation of veterinary services, uncontrolled cattle movement, insuffi ...
DOI:
10.1016/j.vetimm.2009.04.016
PubMed:
19443045

14. Analysis of the seroprevalence of bovine paratuberculosis and the application of modified absorbed ELISA to field sample testing in Korea

Author:
Park, K.T.; Ahn, J.; Davis, W.C.; Koo, H.C.; Kwon, N.H.; Jung, W.K.; Kim, J.M.; Hong, S.K.; Park, Y.H.
Source:
Journal of veterinary science 2006 v.7 no.4 pp. 349-354
ISSN:
1229-845X
Subject:
beef cattle; dairy cattle; cattle diseases; paratuberculosis; seroprevalence; antibody detection; enzyme-linked immunosorbent assay; Mycobacterium avium subsp. paratuberculosis; bacterial antigens; animal age; South Korea
DOI:
10.4142/jvs.2006.7.4.349
PubMed:
17106226
PubMed Central:
PMC3242143

15. Anaplasma marginale Infection with Persistent High-Load Bacteremia Induces a Dysfunctional Memory CD4+ T Lymphocyte Response but Sustained High IgG Titers

Author:
Sushan Han; Junzo Norimine; Kelly A. Brayton; Guy H. Palrmer; Glen A. Scoles; Wendy C. Brown
Source:
Clinical and Vaccine Immunology 2010 v.17 no.12 pp. 1881-1890
ISSN:
1556-6811
Subject:
Anaplasma marginale; CD4-positive T-lymphocytes; animal pathogenic bacteria; apoptosis; bacteremia; bacterial antigens; blood sampling; bovine anaplasmosis; cattle; cell-mediated immunity; disease control; host-pathogen relationships; humoral immunity; immune response; immunization; immunoglobulin G; outer membrane proteins; pathogen survival; spleen
Abstract:
... Control of blood-borne infections is dependent on antigen-specific effector and memory T cells and high-affinity IgG responses. In chronic infections characterized by a high antigen load, it has been shown that antigen-specific T and B cells are vulnerable to downregulation and apoptosis. Anaplasma marginale is a persistent infection of cattle characterized by acute and chronic high-load bacteremi ...
Handle:
10113/56594
DOI:
10.1128/CVI.00257-10
PubMed:
20943884
PubMed Central:
PMC3008194

16. Anaplasma marginale Type IV Secretion System Proteins VirB2, VirB7, VirB11, and VirD4 Are Immunogenic Components of a Protective Bacterial Membrane Vaccine

Author:
Sutten, Eric L.; Norimine, Junzo; Beare, Paul A.; Heinzen, Robert A.; Lopez, Job E.; Morse, Kaitlyn; Brayton, Kelly A.; Gillespie, Joseph J.; Brown, Wendy C.
Source:
Infection and immunity 2010 v.78 no.3 pp. 1314-1325
ISSN:
0019-9567
Subject:
Anaplasma marginale; Ehrlichia; Escherichia coli; T-lymphocytes; bacteria; bacterial antigens; bacterial proteins; bacterial vaccines; cattle; epitope mapping; epitopes; haplotypes; humans; immunization; major histocompatibility complex; outer membrane proteins; pathogens; protein synthesis; proteome; recombinant proteins; secretion; translation (genetics); virulence
Abstract:
... Anaplasma and related Ehrlichia spp. are important tick-borne, Gram-negative bacterial pathogens of livestock and humans that cause acute infection and disease and can persist. Immunization of cattle with an Anaplasma marginale fraction enriched in outer membranes (OM) can provide complete protection against disease and persistent infection. Serological responses of OM vaccinees to the OM proteome ...
DOI:
10.1128/IAI.01207-09
PubMed:
20065028
PubMed Central:
PMC2825951

17. Anti-capsular antibodies activate killing of Escherichia coli O8:K87 by the alternate complement pathway in porcine serum

Author:
Clark, N.M.; Berberov, E.M.; Wang, M.; Moxley, R.A.
Source:
Veterinary immunology and immunopathology 2006 v.114 no.1-2 pp. 185-191
ISSN:
0165-2427
Subject:
complement; blood serum; food animals; antibodies; serotypes; bacterial antigens; enterotoxigenic Escherichia coli; food pathogens; affinity chromatography; immune response; immunization; antiserum; swine
Abstract:
... Enterotoxigenic Escherichia coli (ETEC) strains that produce K88 (F4)+ fimbria are important causes of diarrhea and post-diarrheal septicemia in swine. ETEC O8:K87, a serotype represented by a number of these strains, is typically serum resistant. Strain-specific antibodies are known to activate alternative C pathway-mediated killing of other serum-resistant E. coli [Hill, A.W., Shears, A.L., Hibb ...
DOI:
10.1016/j.vetimm.2006.07.008

18. Anti-enteropathogenic Escherichia coli immunoglobulin Y isolated from eggs laid by immunised Leghorn chickens

Author:
Amaral, J.A.; Franco, M. Tino de; Carneiro-sampaio, M.M.S.; Carbonare, S.B.
Source:
Research in veterinary science 2002 v.72 no.3 pp. 229-234
ISSN:
0034-5288
Subject:
ammonium sulfate; antibodies; bacteria; bacterial antigens; developing countries; dialysis; diarrhea; egg yolk; eggs; enteropathogenic Escherichia coli; enzyme-linked immunosorbent assay; hens; immunization; immunoblotting; immunoglobulin G; immunoglobulin Y; infectious diseases; mammals; molecular weight; pathogens; polyacrylamide gel electrophoresis; sodium dodecyl sulfate; virulence
Abstract:
... IgY, the egg yolk immunoglobulin, equivalent to the IgG from mammals, has been used in veterinary practice for passive immunisation against bacterial or viral infectious diseases. Enteropathogenic Escherichia coli (EPEC) is the main etiological agent of infantile diarrhoea in Brazil and other developing countries. Our aims were to isolate immunoglobulin IgY from egg yolk laid by EPEC -immunised Le ...
DOI:
10.1053/rvsc.2002.0551
PubMed:
12076119

19. Antibiotic-Free Plasmid Stabilization by Operator-Repressor Titration for Vaccine Delivery by Using Live Salmonella enterica Serovar Typhimurium

Author:
Garmory, Helen S.; Leckenby, Matthew W.; Griffin, Kate F.; Elvin, Stephen J.; Taylor, Rosa R.; Hartley, M. Gill; Hanak, Julian A. J.; Williamson, E. Diane; Cranenburgh, Rocky M.
Source:
Infection and immunity 2005 v.73 no.4 pp. 2005-2011
ISSN:
0019-9567
Subject:
immunity; oral vaccination; plague; recombinant DNA; antibiotic resistance; Salmonella Typhimurium; Peyer's patches; mice; bacterial antigens; genetic markers; genes; plasmids; recombinant vaccines; spleen; vaccine development; Yersinia pestis; bacteria
Abstract:
... Live, attenuated bacteria are effective vectors for heterologous antigen delivery. However, loss of heterologous gene-bearing plasmids is problematic, and antibiotics and their resistance genes are not desirable for in vivo DNA vaccine delivery due to biosafety and regulatory concerns. To solve this problem, we engineered the first vaccine delivery strain that has no requirement for antibiotics or ...
DOI:
10.1128/IAI.73.4.2005-2011.2005
PubMed:
15784541
PubMed Central:
PMC1087430

20. Antibodies in cat sera from southern Africa react with antigens of Ehrlichia canis

Author:
Matthewman, L.A.; Kelly, P.J.; Wray, K.; Bryson, N.R.; Rycroft, A.N.; Raoult, D.; Mahan, S.M.
Source:
Veterinary record 1996 v.138 no.15 pp. 364-365
ISSN:
0042-4900
Subject:
cats; Ehrlichia canis; antibodies; blood serum; bacterial antigens; antigen-antibody reactions; Southern Africa
DOI:
10.1136/vr.138.15.364
PubMed:
8737264