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You searched for: Subject term binding capacity Remove constraint Subject term: binding capacity Subject term cytotoxicity Remove constraint Subject term: cytotoxicity
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1. Manipulating immune system using nanoparticles for an effective cancer treatment: Combination of targeted therapy and checkpoint blockage miRNA

Author:
Hanh Thuy Nguyen; Cao Dai Phung; Tuan Hiep Tran; Tung Thanh Pham; Le Minh Pham; Tiep Tien Nguyen; Jee-Heon Jeong; Han-Gon Choi; Sae Kwang Ku; Chul Soon Yong; Jong Oh Kim
Source:
Journal of controlled release 2021 v.329 pp. 524-537
ISSN:
0168-3659
Subject:
CD8-positive T-lymphocytes; antagonists; binding capacity; blood circulation; cell death; cytotoxicity; drugs; immune response; immunosuppression; lymph nodes; microRNA; nanoparticles; neoplasm cells; neoplasms; pH; patients; peptides; spleen; therapeutics
Abstract:
... Accumulating clinical data shows that less than half of patients are beneficial from PD-1/PD-L1 blockage therapy owing to the limited infiltration of effector immune cells into the tumor and abundant of the immunosuppressive factors in the tumor microenvironment. In this study, PD-L1 inhibition therapy and BRAF-targeted therapy, which showed clinical benefit, were combined in a CXCR4-targeted nano ...
DOI:
10.1016/j.jconrel.2020.09.034

2. Synthesis and cytotoxicity of novel 14α-O-(1,4-disubstituted-1,2,3-triazolyl) ester derivatives of andrographolide

Author:
Sudhakar Mokenapelli; Madhu Gutam; Naveen Vadiyaala; Jayaprakash Rao Yerrabelli; Somesh Banerjee; Partha Roy; Rama Krishna Kancha; Bharathi Reddy Kunduru; Someswar Rao Sagurthi; Prasad Rao Chitneni
Source:
Natural product research 2021 v.35 no.2 pp. 289-297
ISSN:
1478-6427
Subject:
active ingredients; alkynes; andrographolide; azides; binding capacity; catalytic activity; cell lines; computer simulation; cycloaddition reactions; cytotoxicity; esterification; neoplasm cells; research; synthesis
Abstract:
... A series of novel 14α-O-(1,4-disubstituted-1,2,3-triazolyl) ester derivatives of andrographolide (5a-n) were synthesized from andrographolide (1). For this endeavour, selective esterification at C-14 hydroxyl group of andrographolide (1) with propiolic acid via protection, deprotection strategy followed by 1,4-regioselective [1,3]dipolar cycloaddition of alkyne, azide using Cu(I) catalyzed Click c ...
DOI:
10.1080/14786419.2019.1628746

3. Anthocyanins decrease the internalization of TiO2 nanoparticles into 3D Caco-2 spheroids

Author:
Junkang Wang; Jiaqi Zhang; Shuang Li; Chaobo Huang; Yixi Xie; Yi Cao
Source:
Food chemistry 2020 v.331 pp. 127360
ISSN:
0308-8146
Subject:
ABC transporters; anthocyanins; binding capacity; colloidal properties; cytotoxicity; fluorescence; food composition; humans; intestines; nanoparticles; oxidative stress; titanium dioxide
Abstract:
... The influence of food components on nanoparticle (NP) internalization indicates a need to investigate the behaviors of NPs in a complex system. This study measured the changes of TiO₂ NP colloidal stability and quenching of anthocyanin fluorescence to indicate NP-anthocyanin interactions, and cytotoxicity, oxidative stress, expression of ABC transporters and intracellular Ti concentrations in 3D C ...
DOI:
10.1016/j.foodchem.2020.127360

4. Effects of lithospermic acid on hIAPP aggregation and amyloid-induced cytotoxicity by multiple analytical methods

Author:
Bo Pang; Xinyu Bian; Junpeng Xing; Shu Liu; Zhiqiang Liu; Fengrui Song
Source:
Biochimica et biophysica acta 2020 v.1868 no.1 pp. 140283
ISSN:
1570-9639
Subject:
amyloid; binding capacity; circular dichroism spectroscopy; computer simulation; cytotoxicity; electrospray ionization mass spectrometry; fluorescence; fluorescence microscopy; humans; lactate dehydrogenase; noninsulin-dependent diabetes mellitus; polypeptides; protective effect; screening; therapeutics; transmission electron microscopy
Abstract:
... The abnormal aggregation of human islet amyloid polypeptide (hIAPP) is a crucial pathogenic factor associated with type 2 diabetes (T2D). The development of effective inhibitors to prevent hIAPP aggregation is a common therapeutic strategy against T2D. Lithospermic acid (LA) is a natural compound with diversified biological activities. In this study, electrospray ionization coupled with ion mobili ...
DOI:
10.1016/j.bbapap.2019.140283

5. Human serum albumin interaction, in silico and anticancer evaluation of Pine-Gold nanoparticles

Author:
K. Anand; R. Rajamanikandan; A. Selva Sharma; M. Ilanchelian; Faez Iqbal Khan; C. Tiloke; Naresh Kumar Katari; P. Boomi; C. Balakumar; M. Saravanan; S. Palanisamy; M. Ramesh; Dakun Lai; A.A. Chuturgoon
Source:
Process biochemistry 2020 v.89 pp. 98-109
ISSN:
1359-5113
Subject:
Fourier transform infrared spectroscopy; absorption; antineoplastic activity; binding capacity; biological assessment; cell viability; computer simulation; cytotoxicity; elemental composition; energy-dispersive X-ray analysis; fluorescence; gas chromatography-mass spectrometry; human serum albumin; humans; kidneys; lung neoplasms; molecular dynamics; nanogold; nanoparticles; nuclear magnetic resonance spectroscopy; scanning electron microscopy; surface plasmon resonance
Abstract:
... Unique characteristics displayed by phytoconstituent conjugated nanoparticles and their crucial interactions with proteins serve to develop nanoparticle-bio-interface platform. Gold nanoparticles of 16 nm in size were generated using aqueous extracts of pine bark and further conjugated to human serum albumin. The gold nanoparticles-protein complex was characterized by surface plasmon resonance, UV ...
DOI:
10.1016/j.procbio.2019.09.036

6. In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines

Author:
Norsyafikah Asyilla Nordin; Vannessa Lawai; Zainab Ngaini; Ainaa Nadiah Abd Halim; Siaw San Hwang; Reagan Entigu Linton; Boon Kiat Lee; Paul Matthew Neilsen
Source:
Natural product research 2020 v.34 no.11 pp. 1505-1514
ISSN:
1478-6427
Subject:
Salix; aspirin; binding capacity; carcinoma; cell lines; cisplatin; colorimetry; computer simulation; cytotoxicity; inhibitory concentration 50; iodine; neoplasm cells; prostaglandin synthase; thiourea
Abstract:
... In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that hal ...
DOI:
10.1080/14786419.2018.1517120

7. Study on the effects of different dimerization positions on biological activity of partial d-Amino acid substitution analogues of Anoplin

Author:
Chao Zhong; Sanhu Gou; Tianqi Liu; Yuewen Zhu; Ningyi Zhu; Hui Liu; Yun Zhang; Junqiu Xie; Xiaomin Guo; Jingman Ni
Source:
Microbial pathogenesis 2020 v.139 pp. 103871
ISSN:
0882-4010
Subject:
DNA; amino acids; antimicrobial peptides; antimicrobial properties; binding capacity; cytotoxicity; dimerization; hemolysis; membrane permeability; multiple drug resistance; rifampicin; therapeutics
Abstract:
... Antimicrobial peptides have recently attracted much attention due to their broad-spectrum antimicrobial activity, rapid microbial effects, and minimal tendency toward resistance development. In this study, a series of new C–C terminals and C–N terminals dimer peptides were designed and synthesized by intermolecular dimerization of the partial d-amino acid substitution analogues of Anoplin, and the ...
DOI:
10.1016/j.micpath.2019.103871

8. Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes

Author:
Ahmet Karadağ; Ali Aydın; Şaban Tekin; Hüseyin Akbaş; Onur Şahin; Fatih Sen
Source:
Life sciences 2020 v.251 pp. 117635
ISSN:
0024-3205
Subject:
DNA topoisomerase; X-radiation; antineoplastic activity; binding capacity; cadmium; cell lines; cell movement; chemical structure; coordination compounds; copper; cytoskeletal proteins; cytotoxicity; dose response; drug therapy; electrophoresis; electrospray ionization mass spectrometry; enzyme inhibition; gold; in vitro studies; inhibitory concentration 50; mechanism of action; neoplasm cells; neoplasms; nickel; nucleic acids; protein binding; solubility; zinc
Abstract:
... Molecular structures containing gold, such as auranofin, have been extensively studied in the diagnosis and treatment of many diseases, including cancer treatment. The pharmacological properties of the newly synthesized unique gold-ligand structures have been reported for different cancer cell lines. However, findings on bishydeten-metal salt complexes with gold are rare. In this work, the synthes ...
DOI:
10.1016/j.lfs.2020.117635

9. TDCPP mimics thyroid hormones associated with the activation of integrin αvβ3 and ERK1/2

Author:
Jian Li; Hedan Liu; Na Li; Jinsheng Wang; Liuting Song
Source:
Chemosphere 2020 v.256 pp. 127066
ISSN:
0045-6535
Subject:
binding capacity; binding sites; cell cycle; cell lines; cell proliferation; computer simulation; cytotoxicity; gene expression; humans; integrins; knowledge; ligands; metabolites; mitogen-activated protein kinase; phosphates; quantitative polymerase chain reaction; rats; signal transduction; thyroid hormone receptors; thyroid hormones
Abstract:
... Tri(1,3-dichloropropyl) phosphate (TDCPP) potentially damages the thyroid system in humans and animals. However, knowledge of its toxic effects and underlying mechanisms is limited. The present study was conducted to determine the thyroid hormone-disrupting effects of TDCPP and its major metabolite, bis(1,3-dichloro-2-propyl) phosphate (BDCPP) in rat pituitary cell lines (GH3). TDCPP and BDCPP, th ...
DOI:
10.1016/j.chemosphere.2020.127066

10. Comprehensive insights into the interactions of dicyclohexyl phthalate and its metabolite to human serum albumin

Author:
Xiaolan Lv; Zheng Jiang; Guofang Zeng; Sujuan Zhao; Na Li; Fengping Chen; Xiaojian Huang; Jia Yao; Xun Tuo
Source:
Food and chemical toxicology 2021 v.155 pp. 112407
ISSN:
0278-6915
Subject:
binding capacity; computer simulation; cytotoxicity; human serum albumin; hydrogen bonding; metabolites; persistent organic pollutants; phthalates; protein secondary structure; van der Waals forces
Abstract:
... Phthalate esters (PAEs) are a type of persistent organic pollutants and have received widespread concerns due to their adverse effects on human health. Dicyclohexyl phthalate (DCHP) and its metabolite monocyclohexyl phthalate (MCHP) were selected to explore the mechanism for interaction of PAEs with human serum albumin (HSA) through molecular docking and several spectroscopic techniques. The resul ...
DOI:
10.1016/j.fct.2021.112407

11. HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor

Author:
Lin Ding; Wenxing Gu; Yifan Zhang; Shujing Yue; Huanli Sun; Jeroen J. L. M. Cornelissen; Zhiyuan Zhong
Source:
Biomacromolecules 2019 v.20 no.10 pp. 3855-3863
ISSN:
1526-4602
Subject:
binding capacity; cytotoxicity; epirubicin; in vitro studies; mice; monoclonal antibodies; ovarian neoplasms; patients; storage quality; storage time; toxins
Abstract:
... Monoclonal antibodies can effectively target to tumors in patients, as validated by antibody–drug conjugates (ADCs). The clinically used ADCs, nevertheless, are restricted to toxins only and suffer from low drug content, excessive use of antibody, and high cost. Here, we report on trastuzumab-decorated disulfide-cross-linked polymersomes (Tra-Ps) for specific delivery of epirubicin hydrochloride ( ...
DOI:
10.1021/acs.biomac.9b00947

12. Identification of multiple ferritin genes in Macrobrachium nipponense and their involvement in redox homeostasis and innate immunity

Author:
Ting Tang; Zilan Yang; Jing Li; Fengyu Yuan; Song Xie; Fengsong Liu
Source:
Fish & shellfish immunology 2019 v.89 pp. 701-709
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Escherichia coli; Macrobrachium nipponense; binding capacity; cytotoxicity; databases; doxorubicin; evolution; ferritin; ferroxidase; fish; functional diversity; genes; gills; hemocytes; hepatopancreas; homeostasis; innate immunity; intestines; ion channels; iron; oxidative stress; peptides; peroxidase; protective effect; shrimp; transcription (genetics); transcriptome
Abstract:
... Based on the transcriptome database, we screened out four ferritin subunit genes (MnFer2-5) from the oriental river prawn Macrobrachium nipponense, which encode two non-secretory and two secretory peptides. MnFer2 and 4 possess a strictly conserved ferroxidase site, and MnFer3 has a non-typical ferroxidase site. MnFer5 seems to be a number of ferritin families, which has a distinct dinuclear metal ...
DOI:
10.1016/j.fsi.2019.04.050

13. In vitro potentiation of carbapenems with tannic acid against carbapenemase‐producing enterobacteriaceae: exploring natural products as potential carbapenemase inhibitors

Author:
A.M. Somboro; J. Osei Sekyere; D.G. Amoako; H.M. Kumalo; R. Khan; L.A. Bester; S.Y. Essack
Source:
Journal of applied microbiology 2019 v.126 no.2 pp. 452-467
ISSN:
1364-5072
Subject:
Enterobacteriaceae; active sites; adjuvants; beta-lactamase; binding capacity; carbapenems; cytotoxicity; enzyme inhibition; enzyme inhibitors; hydrophobicity; inhibitory concentration 50; minimum inhibitory concentration; tannins; transporters
Abstract:
... AIMS: We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory concentrations of carbapenems in the presence and absence of TA and other efflux pump inhibitors, TA‐carbapenemases inhibition assays and computational studies showed that TA had th ...
DOI:
10.1111/jam.14141

14. Ligand-based virtual screening and molecular docking of two cytotoxic compounds isolated from Papaver lacerum

Author:
Omer Bayazeid; Erdal Bedir; Funda N. Yalcin
Source:
Phytochemistry letters 2019 v.30 pp. 26-30
ISSN:
1874-3900
Subject:
Papaver; alcohol oxidoreductases; binding capacity; cell proliferation; cell viability; chemical constituents of plants; computer simulation; cytotoxicity; human cell lines; inhibitory concentration 50; mevalonic acid; receptor protein-tyrosine kinase; screening
Abstract:
... This study revealed that the Papaver lacerum extract strongly inhibited HeLa cell proliferation, resulting in 13% cell viability. As a result of phytochemical studies, one known compound, Tyrosol-1-O-β-xylopyranosyl-(1→6)-O-β-glucopyranoside) (I), and one new compound, 5-O-(6-O-α-rhamnopyronosyl-β-glucopyronosyl) mevalonic acid (II), were isolated. Compounds I and II were found to possess a modera ...
DOI:
10.1016/j.phytol.2019.01.007

15. Structure optimization of dendritic lipopeptide based gene vectors with the assistance from molecular dynamic simulation

Author:
Hong LiangEqual contribution to the manuscript as co-first authors.; Ao Hu; Xiaobing Chen; Rongrong Jin; Kefeng Wang; Bowen Ke; Yu Nie
Source:
Journal of materials chemistry B 2019 v.7 no.6 pp. 915-926
ISSN:
2050-7518
Subject:
DNA; aqueous solutions; arginine; binding capacity; cell membranes; cytotoxicity; dendrimers; fetal bovine serum; genes; human cell lines; lipopeptides; prediction; screening; structure-activity relationships; transfection; viability; viruses; zeta potential
Abstract:
... Disulfide modified lipopeptide assemblies with an arginine-rich dendritic periphery provide a promising platform for effective gene transfer. Dendritic arginine peptides that mimic the cell-penetrating peptides of a virus envelope are vital for complexation, interaction with physical barriers, and final gene release. Here, we report three lipopeptides with different-generation dendritic peripherie ...
DOI:
10.1039/c8tb02650e

16. Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd2(CO3)3@PDA nanoparticles via TLR-2/NF-κB/Akt signaling

Author:
Zhengxiao Ouyang; Tingting Tan; Chunfeng Liu; Juan Duan; Wanchun Wang; Xiaoning Guo; Qing Zhang; Zhihong Li; Qianli Huang; Pengcheng Dou; Tang Liu
Source:
Biomaterials 2019 v.205 pp. 50-63
ISSN:
0142-9612
Subject:
anterior cruciate ligament; apoptosis; binding capacity; cartilage; chondrocytes; coatings; cytotoxicity; hesperetin; image analysis; inflammation; interleukin-1beta; knees; magnetic resonance imaging; magnetism; mice; nanoparticles; osteoarthritis; protective effect; sequence analysis
Abstract:
... The progressive degeneration of cartilage marks the advancement of osteoarthritis (OA), which requires specific targeted treatment for effective cartilage repair. However, there is still no efficient cartilage delivery system or novel magnetic resonance (MR) contrast agent (CA). Herein, we report the synthesis of a novel class of MR CA, Gd2(CO3)3-based nanoparticles (NPs), from a simpler and “gree ...
DOI:
10.1016/j.biomaterials.2019.03.018

17. Topology-assisted, photo-strengthened DNA/siRNA delivery mediated by branched poly(β-amino ester)s via synchronized intracellular kinetics

Author:
Shanzhou Duan; Desheng Cao; Xudong Li; Huifang Zhu; Min Lan; Zhengzhong Tan; Ziyuan Song; Rongying Zhu; Lichen Yin; Yongbing Chen
Source:
Biomaterials science 2019 v.8 no.1 pp. 290-301
ISSN:
2047-4849
Subject:
DNA; binding capacity; condensation reactions; cytotoxicity; genes; irradiation; mammals; moieties; molecular weight; polymers; small interfering RNA; transfection; ultraviolet radiation
Abstract:
... The performance of non-viral gene delivery vehicles, especially cationic polymers, is often challenged by the multiple cellular barriers that pose inconsistent requirements for material properties. A most pronounced inconsistency is exemplified by the molecular weight (MW)-related transfection efficiency and cytotoxicity. In this study, we report the development of photo-degradable, branched poly( ...
DOI:
10.1039/c9bm01452g

18. (–)-β-Homoarginine anhydride, a new antioxidant and tyrosinase inhibitor, and further active components from Trichosanthes truncata

Author:
I-Ting Weng; Yen-An Lin; Guan-Yu Chen; Hsiu-Mei Chiang; Yi-Jung Liu; Chao-Jung Chen; Yu-Hsuan Lan; Chia-Lin Lee
Source:
Natural product research 2020 v.34 no.16 pp. 2262-2268
ISSN:
1478-6427
Subject:
Trichosanthes; amino acids; anhydrides; antioxidants; binding capacity; bleaching agents; cytotoxicity; electrostatic interactions; enzyme inhibitors; enzymes; hydrogen bonding; inhibitory concentration 50; keratinocytes; mushrooms; skin diseases; spectroscopy
Abstract:
... One new amino acid derivative, (–)-β-homoarginine anhydride 1, as well as nine known compounds were isolated from Trichosanthes truncata. The structures of the isolates were elucidated by spectroscopic methods. Among them, compounds 5 and 11 could notably dose-dependently inhibit ROS productions in HaCaT keratinocyte cells without cytotoxicity in the concentration range of 0.2–20 μM. In cell-free ...
DOI:
10.1080/14786419.2018.1531404

19. A Family of Rhodium Complexes with Selective Toxicity toward Mismatch Repair-Deficient Cancers

Author:
Kelsey M. Boyle; Jacqueline K. Barton
Source:
Journal of the American Chemical Society 2018 v.140 no.16 pp. 5612-5624
ISSN:
1520-5126
Subject:
DNA; DNA repair; base pair mismatch; binding capacity; cell proliferation; cytotoxicity; dissociation; imines; ligands; lipophilicity; mitochondria; neoplasms; nucleobases; quinones; rhodium; spectral analysis; therapeutics; toxicity testing
Abstract:
... Rhodium metalloinsertors are a unique set of metal complexes that bind specifically to DNA base pair mismatches in vitro and kill mismatch repair (MMR)-deficient cells at lower concentrations than their MMR-proficient counterparts. A family of metalloinsertors containing rhodium–oxygen ligand coordination, termed “Rh–O” metalloinsertors, has been prepared and shown to have a significant increase i ...
DOI:
10.1021/jacs.8b02271
PubMed:
29620877
PubMed Central:
PMC5965675

20. A novel mitochondria-targeted phosphorescence probe for hypochlorite ions detection in living cells

Author:
Sili Yi; Zhen Lu; Yandai Lin; Jun Wang; Ziwen Qiao; Rongkai Shen; Jin Zhang; Linxi Hou
Source:
Talanta 2020 v.209 pp. 120516
ISSN:
0039-9140
Subject:
binding capacity; breast neoplasms; cell viability; cytotoxicity; detection limit; health hazards; humans; hypochlorites; image analysis; ions; mitochondria; monitoring; neoplasm cells; phosphorescence; surfactants; viability assays; water solubility
Abstract:
... Monitoring hypochlorite anion (ClO⁻) in living cells is particularly meaningful and valuable, because over-exposure of the ClO⁻ may cause a potential health hazard towards animals and humans. Considering the special structure and properties of the gemini surfactant, a novel amphiphilic gemini-iridium complex Ir[(ppy-iso)₂(bpy-tma₂Br₂)] (Ir-iso) with isoniazide as a recognition site for ClO⁻ was de ...
DOI:
10.1016/j.talanta.2019.120516