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- Johnson, Derrick E., et al. Show all 9 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.43 pp. 17368-17373
- binding sites; blood serum; breast neoplasms; cell growth; genes; mutants; neoplasm cells; phosphorylation; protein kinases; serine; starvation; transcription (genetics); ubiquitin-protein ligase; ubiquitination
- ... Large tumor suppressor (LATS)1/2 protein kinases transmit Hippo signaling in response to intercellular contacts and serum levels to limit cell growth via the inhibition of Yes-associated protein (YAP). Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding sit ...
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