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You searched for: Author "Gerber, Vinzenz" Remove constraint Author: "Gerber, Vinzenz" Subject biomarkers Remove constraint Subject: biomarkers Subject humans Remove constraint Subject: humans
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1. Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression

Author:
Gerber, Vinzenz,   et al.   ; Unger, Lucia; Jagannathan, Vidhya; Pacholewska, Alicja; Leeb, Tosso;     Show all 5 Authors
Source:
Journal of veterinary internal medicine 2019 v.33 no.1 pp. 241-250
ISSN:
0891-6640
Subject:
algorithms; biomarkers; blood; blood sampling; carcinogenesis; chromosomes; cohort studies; gene expression regulation; high-throughput nucleotide sequencing; horses; humans; microRNA; prediction; sarcoid
Abstract:
... BACKGROUND: Currently no methods are available to predict the clinical outcome of individual horses with equine sarcoid (ES) disease. OBJECTIVE: To investigate if whole blood microRNA (miRNA) profiles can predict the long‐term development of ES tumors. ANIMALS: Five horses with regression and 5 with progression of ES lesions monitored over 5‐7 years and 5 control horses free of ES for at least 5 y ...
DOI:
10.1111/jvim.15375

2. Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Author:
Gerber, Vinzenz,   et al.   ; Bogedale, Kirsten; Jagannathan, Vidhya; Unger, Lucia;     Show all 4 Authors
Source:
Veterinary and comparative oncology 2019 v.17 no.2 pp. 155-164
ISSN:
1476-5810
Subject:
bioactive properties; biomarkers; chromosomes; gene expression regulation; high-throughput nucleotide sequencing; horses; humans; metabolism; microRNA; neoplasm cells; sarcoid; skin neoplasms; squamous cell carcinoma
Abstract:
... The aim of this study was to investigate microRNA (miRNA) differential expression in the two most common equine skin tumours, equine sarcoid (ES) and squamous cell carcinoma (SCC), and its potential influence on the tumour microenvironment at post‐transcriptional level. We investigated miRNA fingerprints in four subgroups: mild (ESM) and aggressive (ESA) ES and ocular SCC (oSCC) and genital SCC (g ...
DOI:
10.1111/vco.12458

3. MicroRNA fingerprints in serum and whole blood of sarcoid‐affected horses as potential non‐invasive diagnostic biomarkers

Author:
Gerber, Vinzenz,   et al.   ; Unger, Lucia; Pacholewska, Alicja; Leeb, Tosso; Jagannathan, Vidhya;     Show all 5 Authors
Source:
Veterinary and comparative oncology 2019 v.17 no.1 pp. 107-117
ISSN:
1476-5810
Subject:
algorithms; biomarkers; blood serum; gene expression regulation; hemolysis; high-throughput nucleotide sequencing; horses; humans; leukocyte count; microRNA; prediction; sarcoid
Abstract:
... Serum and whole blood microRNA (miRNA) fingerprints have been proposed as a new class of non‐invasive human cancer biomarkers. In this study, we compared equine sarcoid (ES) disease‐specific serum and whole blood miRNA fingerprints and correlated them to miRNA expression in sarcoid tissue. After high throughput sequencing, miRNA differential expression analysis between six ES‐affected and five con ...
DOI:
10.1111/vco.12451