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1. Adverse effects of triclosan on kidney in mice: Implication of lipid metabolism disorders

Author:
Wei Huang; Guodong Cao; Chengliang Deng; Yanyan Chen; Tao Wang; Da Chen; Zongwei Cai
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 481-490
ISSN:
1001-0742
Subject:
beta oxidation; biomarkers; blood serum; corn oil; creatinine; cytokines; dimethyl sulfoxide; dose response; energy; fatty acid metabolism; fibrosis; hepatotoxicity; immune response; inflammation; kidneys; lipids; lipotoxicity; males; mass spectrometry; metabolites; mice; oxidative stress; renal function; thyroid function; triclosan; urea nitrogen; uric acid; China
Abstract:
... Triclosan (TCS) is a ubiquitous antimicrobial used in daily consumer products. Previous reports have shown that TCS could induce hepatotoxicity, endocrine disruption, disturbance on immune function and impaired thyroid function. Kidney is critical in the elimination of toxins, while the effects of TCS on kidney have not yet been well-characterized. The aim of the present study was to investigate t ...
DOI:
10.1016/j.jes.2021.11.032

2. Biological mass spectrometry analysis for traceability of production method and harvesting seasons of sea cucumber (Apostichopus japonicus)

Author:
Bingxue Jiang; Xiaomei Zhang; Mao Ding; Hongwei Zhang; Lipin Chen; Zhaojie Li; Changhu Xue; Xiaoming Jiang; Yanchao Wang
Source:
Food control 2023 v.143 pp. 109297
ISSN:
0956-7135
Subject:
Apostichopus japonicus; autumn; biomarkers; chemometrics; food safety; gene ontology; mass spectrometry; proteome; proteomics; summer; traceability
Abstract:
... The focus of this paper was to investigate the potential of distinguishing sea cucumbers from different production methods (farmed vs wild-caught) and different seasons (autumn vs summer) at the proteomic level. Based on biological mass spectrometry with sequential window acquisition of all the theoretical fragment ion mass spectra (SWATH) acquisition mode, the proteomes of Apostichopus japonicus ...
DOI:
10.1016/j.foodcont.2022.109297

3. Determination of porcine derived components in gelatin and gelatin-containing foods by high performance liquid chromatography-tandem mass spectrometry

Author:
Xiaoyan Zhu; Shuqing Gu; Dehua Guo; Xinxin Huang; Niannian Chen; Bing Niu; Xiaojun Deng
Source:
Food hydrocolloids 2023 v.134 pp. 107978
ISSN:
0268-005X
Subject:
adulterated products; asses; biomarkers; candy; cattle; gelatin; hydrocolloids; peptides; proteomics; quantitative analysis; swine; tandem mass spectrometry
Abstract:
... Detection and quantitation of porcine derived components in bovine and donkey gelatins and gelatin-containing foods is required for religious practices and consumer economic interests. In this study, shot-gun proteomics approaches were implemented to identify species-specific peptide biomarkers of three main gelatin origins, including porcine, bovine and donkey. Tryptic gelatin peptides were separ ...
DOI:
10.1016/j.foodhyd.2022.107978

4. Disposable electropolymerized molecularly imprinted electrochemical sensor for determination of breast cancer biomarker CA 15-3 in human serum samples

Author:
Ana Elisa F. Oliveira; Arnaldo C. Pereira; Lucas F. Ferreira
Source:
Talanta 2023 v.252 pp. 123819
ISSN:
0039-9140
Subject:
Fourier transform infrared spectroscopy; atomic force microscopy; biomarkers; blood serum; breast neoplasms; carbon nanotubes; electrodes; graphene; humans; nanogold; nanosilver; oxalic acid; polymerization; roughness; saliva; sensors (equipment)
Abstract:
... Initially, a printed electrode was fabricated in a paper substrate using carbon nanotube ink, graphite pencil and silver nanoparticle ink. For that the electrode was modified with gold nanoparticles and a molecularly imprintedpolymer (MIP) using CA 15-3 as target molecule. The Atomic Force Microscopy (AFM) images exhibited the change in the morphology after each electrode modification. The roughne ...
DOI:
10.1016/j.talanta.2022.123819

5. Europium-modified carbon nitride nanosheets for smartphone-based fluorescence sensitive recognition of anthrax biomarker dipicolinic acid

Author:
Mi Yuan; Yu Jin; Long Yu; Yiming Bu; Mingtai Sun; Chao Yuan; Suhua Wang
Source:
Food chemistry 2023 v.398 pp. 133884
ISSN:
0308-8146
Subject:
anthrax; biomarkers; calibration; carbon nitride; colorimetry; detection limit; emissions factor; fluorescence; food chemistry; food safety; graphene; mobile telephones; nanosheets; public health
Abstract:
... Development of selective and sensitive methods for the detection of 2, 6-dipicolinic acid (DPA), a biomarker produced by bacterial spores, is of great significance for maintaining public health and food safety. Herein, a ratiometric fluorescence strategy using graphene carbon nitride (g-C₃N₄) coupled with Eu³⁺ is designed for the assay of DPA. As the concentration of DPA increases, the emission in ...
DOI:
10.1016/j.foodchem.2022.133884

6. Fecal metabolomics reveals the positive effect of ethanol extract of propolis on T2DM mice

Author:
Chunmei Wang; Huiting Zhao; Kai Xu; Yali Du; Jinjia Liu; Jinfei Wang; Yusuo Jiang
Source:
Food science and human wellness 2023 v.12 no.1 pp. 161-172
ISSN:
2213-4530
Subject:
alanine transaminase; aspartate transaminase; biomarkers; blood; blood glucose; body weight; ethanol; food science; glycerophospholipids; homeostasis; humans; insulin; insulin resistance; liver; metabolomics; noninsulin-dependent diabetes mellitus; propolis; spectroscopy; sphingolipids; sterols
Abstract:
... A large number of studies have shown that propolis has positive effects in the treatment of type 2 diabetes mellitus (T2DM). However, there are have only been a few reports that are based on an ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UPLC-Q-TOF-MS) analysis of the fecal metabolomics of ethanol extract of propolis (EEP) in the treatment of T2DM. The ...
DOI:
10.1016/j.fshw.2022.07.034

7. Microfluidic amperometric immunosensor based on porous nanomaterial towards claudin7 determination for colorectal cancer diagnosis

Author:
Francisco G. Ortega; Germán E. Gomez; Chiara Boni; Inés Cañas García; Carmen Garrido Navas; Richard F. D'vries; María Pilar Molina Vallejos; María José Serrano; Germán A. Messina; José Expósito Hernández; Martín A. Fernández-Baldo
Source:
Talanta 2023 v.251 pp. 123766
ISSN:
0039-9140
Subject:
biomarkers; chemical bonding; colorectal neoplasms; detection limit; immunosensors; medicine
Abstract:
... In this work, we present a microfluidic amperometric immunosensor for cancer biomarker claudin7 (CLD7) determination in circulating extracellular vesicles (EVs) as well as its validation in colorectal cancer (CC) patients. The device is based on synthetized nanosized MIL-125-NH₂ particles, covalently anchored to the central channel of the microfluidic immunosensor. This nanomaterial was employed a ...
DOI:
10.1016/j.talanta.2022.123766

8. Shifts in the bacterial community caused by combined pollutant loads in the North Canal River, China

Author:
Shengguang Yuan; Wenqiang Zhang; Wenye Li; Zhenhan Li; Minshan Wu; Baoqing Shan
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 541-551
ISSN:
1001-0742
Subject:
Pseudomonas; Ruminococcus; bacterial communities; biomarkers; nitrogen; phosphorus; pollutants; riparian areas; rivers; sewage; spatial variation; China
Abstract:
... A typical anthropogenically disturbed urban river polluted by a combination of conventional pollutants (nitrogen and phosphorus pollution) and heavy metals was investigated along a 238 km stretch. Changes in the bacterial community were evaluated using high-throughput sequencing, and the relationships between bacteria, heavy metals, and conventional pollutants were investigated. There was large sp ...
DOI:
10.1016/j.jes.2022.05.026

9. Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Author:
Haoduo Zhao; Min Liu; Junjie Yang; Yuyang Chen; Mingliang Fang
Source:
Frontiers of environmental science & engineering 2023 v.17 no.1 pp. 4
ISSN:
2095-2201
Subject:
biomarkers; biosynthesis; bisphenol A; cartography; cell growth; cell proliferation; dose response; endocrine-disrupting chemicals; energy; environmental science; glutamic acid; glutamine; glycolysis; homeostasis; metabolites; metabolome; metabolomics; models; nucleosides; oxidative phosphorylation; oxidative stress; phosphates; risk assessment; stress response; sugars; xenobiotics
Abstract:
... The biochemical consequences induced by xenobiotic stress are featured in dose-response and time-resolved landscapes. Understanding the dynamic process of cellular adaptations is crucial in conducting the risk assessment for chemical exposure. As one of the most phenotype-related omics, metabolome in response to environmental stress can vary from seconds to days. Up to now, very few dynamic metabo ...
DOI:
10.1007/s11783-023-1604-5

10. Tomato classification using mass spectrometry-machine learning technique: A food safety-enhancing platform

Author:
Arthur Noin de Oliveira; Sophia Regina Frazatto Bolognini; Luiz Claudio Navarro; Jeany Delafiori; Geovana Manzan Sales; Diogo Noin de Oliveira; Rodrigo Ramos Catharino
Source:
Food chemistry 2023 v.398 pp. 133870
ISSN:
0308-8146
Subject:
algorithms; biomarkers; decision support systems; electrospray ionization mass spectrometry; food chemistry; food safety; fruits; models; silica gel; tomatoes
Abstract:
... Food safety and quality assessment mechanisms are unmet needs that industries and countries have been continuously facing in recent years. Our study aimed at developing a platform using Machine Learning algorithms to analyze Mass Spectrometry data for classification of tomatoes on organic and non-organic. Tomato samples were analyzed using silica gel plates and direct-infusion electrospray-ionizat ...
DOI:
10.1016/j.foodchem.2022.133870

11. Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles

Author:
Amanda Pereira da Costa Araújo; Thiarlen Marinho da Luz; Mohamed Ahmed Ibrahim Ahmed; Mir Mohammad Ali; Md. Mostafizur Rahman; Bojan Nataraj; Daniela de Melo e Silva; Damià Barceló; Guilherme Malafaia
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 465-482
ISSN:
1001-0742
Subject:
Physalaemus; amphibians; antioxidants; biomarkers; biometry; cholinesterase; cytotoxicity; microplastics; mutagenicity; polyethylene; principal component analysis; stress response; water pollution; China
Abstract:
... Studies in recent years have shown that aquatic pollution by microplastics (MPs) can be considered to pose additional stress to amphibian populations. However, our knowledge of how MPs affect amphibians is very rudimentary, and even more limited is our understanding of their effects in combination with other emerging pollutants. Thus, we aimed to evaluate the possible toxicity of polyethylene MPs ...
DOI:
10.1016/j.jes.2022.05.013

12. Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo[a]pyrene exposure: Cellular and transcriptomic insights

Author:
Jiezhang Mo; Miles Teng Wan; Doris Wai-Ting Au; Jingchun Shi; Nathan Tam; Xian Qin; Napo K.M. Cheung; Keng Po Lai; Christoph Winkler; Richard Yuen-Chong Kong; Frauke Seemann
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 336-348
ISSN:
1001-0742
Subject:
Oryzias latipes; ancestry; biomarkers; bone formation; bone morphogenetic proteins; bone resorption; environmental health; epigenetics; histones; males; microRNA; osteoblasts; osteoclasts; oxidative stress; pollutants; progeny; stress response; toxicity; transcriptome; transcriptomics; wild fish; China
Abstract:
... Benzo[a]pyrene (BaP), a ubiquitous pollutant, raises environmental health concerns due to induction of bone toxicity in the unexposed offspring. Exposure of F0 ancestor medaka (Oryzias latipes) to 1 μg/L BaP for 21 days causes reduced vertebral bone thickness in the unexposed F3 male offspring. To reveal the inherited modifications, osteoblast (OB) abundance and molecular signaling pathways of tra ...
DOI:
10.1016/j.jes.2022.04.051

13. A novel electrochemical strategy for NT-proBNP detection using IMFET for monitoring heart failure by saliva analysis

Author:
Hamdi Ben Halima; Francesca G. Bellagambi; Marie Hangouët; Albert Alcacer; Norman Pfeiffer; Albert Heuberger; Nadia Zine; Joan Bausells; Abdelhamid Elaissari; Abdelhamid Errachid
Source:
Talanta 2023 v.251 pp. 123759
ISSN:
0039-9140
Subject:
antibodies; biomarkers; detection limit; dielectric spectroscopy; elderly; electrochemistry; enzyme-linked immunosorbent assay; health services; heart failure; humans; immunosensors; mortality; natriuretic peptides; phosphates; saliva; therapeutics; transistors
Abstract:
... Heart failure (HF) is a chronic cardiovascular disease that represents main cause of mortality worldwide, particularly for elderly. N-terminal pro-brain natriuretic peptide (NT-proBNP) was identified as the gold standard biomarker for HF diagnosis and therapy monitoring. Presently, saliva analysis represents an emerging and powerful tool for clinical applications and electrochemical immunosensors ...
DOI:
10.1016/j.talanta.2022.123759

14. A novel label-free universal biosensing platform based on CRISPR/Cas12a for biomarker detection

Author:
Xiaomei Mu; Xin Wang; Yuxin Qin; Yong Huang; Jianniao Tian; Shulin Zhao
Source:
Talanta 2023 v.251 pp. 123795
ISSN:
0039-9140
Subject:
DNA; biomarkers; biosensors; disease surveillance; enzyme activity; fluorescence; hydrolysis; microRNA; nanosilver
Abstract:
... The development of a biosensing platform with high sensitivity, high specificity, and low cost for the detection of biomarkers, especially one that is programmable and universal, is critical for disease surveillance and diagnosis, yet it remains a difficulty. Herein, we combined the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system with a fluorescent label-free biosenso ...
DOI:
10.1016/j.talanta.2022.123795

15. -Omics potential of in vitro skin models for radiation exposure

Author:
Leyla A. Akh; Mohammad O. Ishak; Jennifer F. Harris; Trevor G. Glaros; Zachary J. Sasiene; Phillip M. Mach; Laura M. Lilley; Ethan M. McBride
Source:
Cellular and molecular life sciences 2022 v.79 no.7 pp. 390
ISSN:
1420-682X
Subject:
artificial skin; biomarkers; evolution; exposure duration; exposure models; ionizing radiation; skinning; wills
Abstract:
... There is a growing need to uncover biomarkers of ionizing radiation exposure that leads to a better understanding of how exposures take place, including dose type, rate, and time since exposure. As one of the first organs to be exposed to external sources of ionizing radiation, skin is uniquely positioned in terms of model systems for radiation exposure study. The simultaneous evolution of both MS ...
DOI:
10.1007/s00018-022-04394-z

16. 1-Pentadecene, a volatile biomarker for the detection of Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) infested brown rice under different temperatures

Author:
Xuemei Tian; Jiarong Hao; Fenghua Wu; Hao Hu; Guoxin Zhou; Xingquan Liu; Tao Zhang
Source:
Journal of stored products research 2022 v.97 pp. 101981
ISSN:
0022-474X
Subject:
Tribolium castaneum; biomarkers; brown rice; gas chromatography-mass spectrometry; insect infestations; pests; research; stored grain
Abstract:
... Tribolium castaneum, a secondary pest that feeds on processed stored grains, can cause serious damage on stored grain. To reduce the loss of stored grain caused by pest infestation, monitoring and early detection of insects are essential. volatile compounds arising from insects or insect-infested stored products can be appropriate biomarkers. In this study, gas chromatography–mass spectrometry (HS ...
DOI:
10.1016/j.jspr.2022.101981

17. 15-F2t-Isoprostane Favors an Anti-Inflammatory Phenotype in RAW 264.7 Macrophages during Endotoxin Challenge

Author:
Ashley K. Putman; G. Andres Contreras
Source:
Antioxidants 2022 v.11 no.3 pp. -
ISSN:
2076-3921
Subject:
biomarkers; byproducts; endotoxins; gene expression; homeostasis; inflammation; interleukin-10; interleukin-6; lipid peroxidation; lipopolysaccharides; macrophages; oxidative stress; phenotype; proteomics; transcriptomics
Abstract:
... Dysregulated inflammation and oxidative stress are major underlying components of several diseases. Macrophages are critical effector cells in immune responses, functioning to progress and resolve inflammation during such diseases. These mononuclear cells regulate inflammatory responses by exhibiting a range of phenotypes that evolve with the process, first promoting inflammation but then switchin ...
DOI:
10.3390/antiox11030586

18. 16S rRNA gene sequencing reveals altered composition of gut microbiota in postoperative individuals with renal stones

Author:
Qiong Deng; Zhu Wang; Jieyan Wang; Jianwen Zhang; Ying Zhang; Hui Liang
Source:
Letters in applied microbiology 2022 v.75 no.2 pp. 271-280
ISSN:
0266-8254
Subject:
Escherichia; Pseudomonas; biomarkers; creatinine; discriminant analysis; feces; flora; genes; intestinal microorganisms; renal calculi; ribosomal RNA; surgery; urea
Abstract:
... Renal stones are a common urological disease with high prevalence and recurrence rates. Characterizing gut microbiome profiles of first‐onset renal calculi patients, both before and after surgery, may provide valuable insights and identify potential biomarkers for the disease. In this study, we explored the associations between the gut microbiome and renal stone formation using 16S ribosomal RNA ( ...
DOI:
10.1111/lam.13701

19. IL- 17A, IL-17E and IL-17F as Potential Biomarkers for the Intensity of Low-Grade Inflammation and the Risk of Cardiovascular Diseases in Obese People

Author:
Ewelina Polak-Szczybyło; Jacek Tabarkiewicz
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
adipocytes; adults; alcohols; atherosclerosis; beta-adrenergic antagonists; biomarkers; blood serum; breakfast; folic acid; food frequency questionnaires; food records; inflammation; interleukin-17; iron; potassium; red meat; risk; subcutaneous fat; sweets
Abstract:
... Low-grade inflammation is a factor that predisposes to many obesity-related comorbidities. The immune mechanisms controlling the inflammatory response related to the secretory activity of adipocytes and its consequences for the organism are still under investigation. Methods: 84 obese adult volunteers (BMI ≥ 30 kg/m²) were tested by BIA. Serum samples were collected to analyze the concentrations o ...
DOI:
10.3390/nu14030643

20. 1H NMR Profiling of Honey Bee Bodies Revealed Metabolic Differences between Summer and Winter Bees

Author:
Saetbyeol Lee; Filip Kalcic; Iola F. Duarte; Dalibor Titera; Martin Kamler; Pavel Mrna; Pavel Hyrsl; Jiri Danihlik; Pavel Dobes; Martin Kunc; Anna Pudlo; Jaroslav Havlik
Source:
Insects 2022 v.13 no.2 pp. -
ISSN:
2075-4450
Subject:
Apis mellifera; alanine; biomarkers; longevity; metabolites; multivariate analysis; nuclear magnetic resonance spectroscopy; overwintering; phenotype; proline; summer; trehalose
Abstract:
... In temperate climates, honey bee workers of the species Apis mellifera have different lifespans depending on the seasonal phenotype: summer bees (short lifespan) and winter bees (long lifespan). Many studies have revealed the biochemical parameters involved in the lifespan differentiation of summer and winter bees. However, comprehensive information regarding the metabolic changes occurring in the ...
DOI:
10.3390/insects13020193

21. 1H NMR serum metabolomics and its endogenous network pharmacological analysis of Gushudan on kidney-yang-deficiency-syndrome rats

Author:
Qisheng Feng; Lin Tong; Qing Lu; Shuo Liu; Longshan Zhao; Zhili Xiong
Source:
Analytical biochemistry 2022 v.643 pp. 114580
ISSN:
0003-2697
Subject:
Oriental traditional medicine; amino acid metabolism; animal models; arginine; biochemical pathways; biomarkers; blood serum; carbohydrate metabolism; cortisol; dicarboxylic acids; intestinal microorganisms; kidneys; metabolomics; pharmacodynamics; proline
Abstract:
... The pharmacodynamics, ¹H NMR metabolomics and endogenous network pharmacology strategy approaches were integrated to investigate the preventive mechanism of Gushudan (GSD) on kidney-yang-deficiency-syndrome (KYDS) rats in this study. Firstly, the KYDS rat model was achieved by hydrocortisone induction, and the efficacy of GSD on KYDS model rats was assessed by the pharmacodynamic indicators. Next, ...
DOI:
10.1016/j.ab.2022.114580

22. 1H NMR-Based Metabolomics Reveals the Intrinsic Interaction of Age, Plasma Signature Metabolites, and Nutrient Intake in the Longevity Population in Guangxi, China

Author:
He Li; Minhong Ren; Quanyang Li
Source:
Nutrients 2022 v.14 no.12 pp. -
ISSN:
2072-6643
Subject:
alanine; aspartic acid; biomarkers; biosynthesis; carnitine; choline; citrates; dietary fiber; elderly; energy; fat intake; food composition; gluconeogenesis; glutamic acid; glycolysis; glycoproteins; lactic acid; longevity; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; phenylalanine; trimethylamine; tryptophan; tyrosine; valine; China
Abstract:
... Health and longevity populations have distinct metabolic and nutrient intake profiles. However, the relationship between biomarkers of longevity-related metabolites and dietary nutrient intake profiles, as well as metabolic markers associated with longevity features, have not been fully elucidated. Therefore, ¹H nuclear magnetic resonance (¹H NMR)-based plasma metabolomics profiling was conducted ...
DOI:
10.3390/nu14122539

23. 1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression

Author:
Ke-xin Wang; Guan-hua Du; Xue-mei Qin; Li Gao
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.4 pp. 1525-1537
ISSN:
1618-2642
Subject:
analytical chemistry; biomarkers; choline; creatinine; early diagnosis; hepatoma; metabolism; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; putrescine; taurine
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most extensive and most deadly cancers in the world. Biomarkers for early diagnosis of HCC are still lacking, and noninvasive and effective biomarkers are urgently needed. Metabolomics is committed to studying the changes of metabolites under stimulation, and provides a new approach for discovery of potential biomarkers. In the current work, ¹H nuclear ...
DOI:
10.1007/s00216-021-03768-9

24. IL- 1R8 as Pathoimmunological Marker for Severity of Canine Chronic Enteropathy

Author:
Federica Riva; Laura Bianchessi; Camilla Recordati; Alessia Inglesi; Vittoria Castiglioni; Lauretta Turin
Source:
Veterinary sciences 2022 v.9 no.6 pp. -
ISSN:
2306-7381
Subject:
Helicobacter; biomarkers; dog breeds; dogs; endoscopy; gastrointestinal diseases; hyperplasia; inflammation; large intestine; quantitative polymerase chain reaction
Abstract:
... Chronic enteropathy (CE) is a severe multifactorial gastrointestinal disease that affects dogs and is driven by poorly characterized inflammatory pathways. Imbalance of pro-inflammatory response regulators, including IL-1R8, may be due to different factors, among which the infection with Helicobacteraceae is known to lead to a vicious circle in which excessive pro-inflammatory signaling and gastro ...
DOI:
10.3390/vetsci9060295

25. IL- 1Ra and sVCAM-1 in chikungunya virus infection

Author:
Chintana Chirathaworn; Jira Chansaenroj; Watchadaporn Chaisuriyong; Somrat Lertmaharit; Yong Poovorawan
Source:
Acta tropica 2022 v.233 pp. 106548
ISSN:
0001-706X
Subject:
Chikungunya fever; Chikungunya virus; antagonists; biomarkers; disease severity; inflammation; interleukin-1; observational studies; pain; patients; vascular cell adhesion molecules
Abstract:
... Mediators involving in inflammation induction and regulation have been investigated as biomarkers for severe joint pain induced by chikungunya virus (CHIKV) infection. In this report, observational study was conducted to determine levels of an antagonist of interleukin-1 receptor (IL-1Ra) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in CHIKV patients with different disease severity. CHI ...
DOI:
10.1016/j.actatropica.2022.106548

26. 2-Mercaptobenzothiazole-supported ratiometric fluorescent copper nanoclusters for activatable GSH sensing to drive tumor recognition

Author:
Lin Li; Juan Chen; Ruichun Jin; Yuxing Yan; Zhuoran Song; Jiawei Wang; Xiyu Wang; Qiuyun Zhang; Caifeng Zhang
Source:
Colloids and surfaces 2022 v.217 pp. 112698
ISSN:
0927-7765
Subject:
ambient temperature; biomarkers; biosensors; colorimetry; fluorescence; neoplasms; permeability; polyvinylpyrrolidone
Abstract:
... The development of GSH (one of tumor biomarkers)-specific response fluorescent sensor that are free from environmental and instrument interference, is pivotal to precisely recognize tumor in biological systems. Herein, a novel activatable ratiometric fluorescent copper nanocluster (MBT@PVP-CuNCs) biosensor was designed by one-pot approach at room temperature. The dual-emission biosensor can be app ...
DOI:
10.1016/j.colsurfb.2022.112698

27. 2D HILIC‐ELSD/UPLC‐Q‐TOF‐MS Method for Acquiring Phospholipid Profiles and the Application in Caenorhabditis elegans

Author:
Xiaotian Sun; Tao Zhang; Pinzhen Zhao; Guanjun Tao; Ruijie Liu; Ming Chang; Xingguo Wang
Source:
European journal of lipid science and technology 2022 v.124 no.2 pp. e2100075
ISSN:
1438-7697
Subject:
Caenorhabditis elegans; arachidonic acid; biomarkers; databases; disease diagnosis; eicosapentaenoic acid; hydrophilic interaction chromatography; lipidomics; mass spectrometry; oleic acid; phospholipids; quantitative analysis
Abstract:
... Phospholipids are the main constituent of cellular membranes and have recently been identified to have diagnostic value as biomarkers for many diseases. Accordingly, much emphasis is now laid on developing optimal analytical techniques for the phospholipid profiles of various biological samples. In the present study, different classes of phospholipids are first separated by optimized hydrophilic i ...
DOI:
10.1002/ejlt.202100075

28. 2D transparent few-layered hydrogen substituted graphdiyne nano-interface for unprecedented ultralow ANXA2 cancer biomarker detection

Author:
Dipti Chauhan; Yogesh Kumar; Ramesh Chandra; Suveen Kumar
Source:
Biosensors & bioelectronics 2022 v.213 pp. 114433
ISSN:
0956-5663
Subject:
biomarkers; biosensors; bovine serum albumin; electrochemistry; electrophoresis; enzymes; glass; hydrogen; indium tin oxide; liver neoplasms; nanosheets; porosity; semiconductors; spectroscopy; surface area; voltammetry
Abstract:
... Herein, we report synthesis of 2D few-layered transparent hydrogen substituted graphdiyne (HsGDY) nanosheets and explored its electrochemical characteristics for the first time to develop a nano-interface for cancer biomarker detection [liver cancer (LC) biomarker; ANXA2]. The semiconducting HsGDY (band gap; 1.98 eV) contains considerable number of sp and sp² hybridised π-electrons with abundant h ...
DOI:
10.1016/j.bios.2022.114433

29. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis

Author:
Amit Kaushik; Sabyasachi Bandyopadhyay; Chhavi Porwal; Alagiri Srinivasan; Lokesh A. Rukmangadachar; Gururao Hariprasad; Srujana Kola; Jitender Kataria; Urvashi B. Singh
Source:
Biochemical and biophysical research communications 2022 v.619 pp. 15-21
ISSN:
0006-291X
Subject:
Mycobacterium tuberculosis; Streptococcus; adenosinetriphosphatase; biomarkers; cell walls; extracellular space; gel electrophoresis; gene expression regulation; genes; humans; immune response; liquid chromatography; pathogenicity; plasma membrane; pneumonia; protein-protein interactions; proteome; proteomics; research; tandem mass spectrometry; tuberculosis; urine
Abstract:
... In the absence of a sensitive and specific diagnostic modality capable of detecting all forms of tuberculosis (TB), proteomics may identify specific Mycobacterium tuberculosis (M.tb) proteins in urine, with a potential as biomarkers. To identify candidate biomarkers for TB, proteome profile of urine from pulmonary TB patients was compared with non-disease controls (NDC) and disease controls (DC, S ...
DOI:
10.1016/j.bbrc.2022.06.021

30. 2‐Methylhopanoids in geographically distinct, arid biological soil crusts are primarily cyanobacterial in origin

Author:
Tamsyn J. Garby; Matthew Jordan; Verlaine Timms; Malcolm R. Walter; Brett A. Neilan
Source:
Environmental microbiology reports 2022 v.14 no.1 pp. 164-169
ISSN:
1758-2229
Subject:
biomarkers; biosynthesis; microbiology; Utah
Abstract:
... Microbial palaeontology is largely reliant on the interpretation of geologically stable biomarkers or molecular fossils. Biomolecules that are both specific to particular groups of organisms and stable on a geological scale are invaluable for tracing the emergence and diversification of lifeforms, particularly in cases where mineral fossils are lacking. 2‐Methylhopanoids and their diagenic product ...
DOI:
10.1111/1758-2229.13037

31. 3D Biofabrication of a Cardiac Tissue Construct for Sustained Longevity and Function

Author:
Matthew Alonzo; Raven El Khoury; Naveen Nagiah; Vikram Thakur; Munmun Chattopadhyay; Binata Joddar
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 21800-21813
ISSN:
1944-8252
Subject:
Fourier transform infrared spectroscopy; atrophy; biofabrication; biomarkers; cardiomyocytes; cardiovascular diseases; cell culture; cytotoxicity; drugs; electron microscopy; fibroblasts; flow cytometry; humans; hydrogels; longevity; microgravity; models; modulus of elasticity; organoids; physiology; reflectance; three-dimensional printing; viability
Abstract:
... In this study, we developed three-dimensional (3D) printed annular ring-like scaffolds of hydrogel (gelatin–alginate) constructs encapsulated with a mixture of human cardiac AC16 cardiomyocytes (CMs), fibroblasts (CFs), and microvascular endothelial cells (ECs) as cardiac organoid models in preparation for investigating the role of microgravity in cardiovascular disease initiation and development. ...
DOI:
10.1021/acsami.1c23883

32. 3D origami paper-based ratiometric fluorescent microfluidic device for visual point-of-care detection of alkaline phosphatase and butyrylcholinesterase

Author:
Yongfeng Zhu; Xia Tong; Qisheng Wei; Guihan Cai; Yuanxin Cao; Chaoying Tong; Shuyun Shi; Fang Wang
Source:
Biosensors & bioelectronics 2022 v.196 pp. 113691
ISSN:
0956-5663
Subject:
alkaline phosphatase; biomarkers; biosensors; blood serum; catalytic activity; cholinesterase; computer software; fluorescence; humans; mobile telephones; quantitative analysis; therapeutics
Abstract:
... On-site multiplex enzyme detection is crucial for diagnosis, therapeutics and prognostic. To date, it is still a daunting challenge to develop portable, low-cost, and efficient multi-enzyme detection methods. Herein, a novel sample-in-result-out platform integrating ratiometric fluorescent assays with 3D origami microfluidic paper-based device (μPAD) was developed for simultaneous visual point-of- ...
DOI:
10.1016/j.bios.2021.113691

33. 3F-α-pyrrolydinovalerophenone (3F-α-PVP) in vitro human metabolism: Multiple in silico predictions to assist in LC-HRMS/MS analysis and targeted/untargeted data mining

Author:
Jeremy Carlier; Diletta Berardinelli; Eva Montanari; Ascanio Sirignano; Annagiulia Di Trana; Francesco P. Busardò
Source:
Journal of chromatography 2022 v.1193 pp. 123162
ISSN:
1570-0232
Subject:
biochemical pathways; biomarkers; cannabinoids; chromatography; computer simulation; forensic sciences; hepatocytes; humans; hydroxylation; metabolism; metabolites; pentanols; poisoning; toxicology; Sweden
Abstract:
... Synthetic cathinones (SCs) constitute a heterogenous class of new psychoactive substances (NPS), structurally related to cathinone. SCs represent the widest NPS class, second to synthetic cannabinoids, accounting for approximately 160 different analogues with substitution at the phenyl group, the amine group, or the alkyl chain. In 2020, α-pyrrolidonophenone analogues were the most trafficked SCs, ...
DOI:
10.1016/j.jchromb.2022.123162

34. 5-Methoxytryptophan pretreatment alleviates lipopolysaccharide-induced cardiac injury and dysfunction

Author:
Yang Fu; Yi-Fei Dong
Source:
Applied biological chemistry 2022 v.65 no.1 pp. 36
ISSN:
2468-0834
Subject:
Western blotting; apoptosis; biomarkers; cardiomyopathy; cardioprotective effect; echocardiography; fibroblasts; heart; inflammation; interleukin-10; interleukin-6; lipopolysaccharides; metabolites; protein content; therapeutics; tryptophan
Abstract:
... Reducing inflammation is a promising therapeutic approach for sepsis-induced cardiomyopathy (SIC). The 5-Methoxytryptophan (5-MTP) is a tryptophan metabolite that demonstrates anti-inflammatory, anti-fibrosis, anti-tumorigenesis, and anti-senescence features. Current investigations aimed to assess the 5-MTP pretreatment impacts on lipopolysaccharide (LPS)-induced cardiac injury and dysfunction. Fo ...
DOI:
10.1186/s13765-022-00705-x

35. 5mC-Related lncRNAs as Potential Prognostic Biomarkers in Colon Adenocarcinoma

Author:
Yinghui Huang; Huiqian Huang; Yong Wang; Hui Liu; Yingdan Huang
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
5-methylcytosine; adenocarcinoma; biomarkers; colon; databases; immunotherapy; metastasis; nomogram; prediction; prognosis; regression analysis; risk
Abstract:
... Globally, colon adenocarcinoma (COAD) is one of the most frequent types of malignant tumors. About 40~50% of patients with advanced colon adenocarcinoma die from recurrence and metastasis. Long non-coding RNAs (lncRNAs) and 5-methylcytosine (5mC) regulatory genes have been demonstrated to involve in the progression and prognosis of COAD. The goal of this study was to explore the biological charact ...
DOI:
10.3390/biology11020231

36. 5‐Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E‐Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption

Author:
Yiming Hao; Zihui Yang; Qing Li; Ziyuan Wang; Jie Liu; Jing Wang
Source:
Molecular nutrition & food research 2022 v.66 no.9 pp. e2101114
ISSN:
1613-4125
Subject:
Western blotting; apoptosis; atherosclerosis; biomarkers; blood serum; cholesterol; fluorescent antibody technique; food research; grain consumption; health claims; heart; high fat diet; histology; ingredients; mitochondria; risk; triacylglycerols; whole grain foods
Abstract:
... SCOPE: Whole grain consumption has been proven to be inversely associated with the risk of cardiovascular diseases. As a biomarker for whole grain dietary intake, 5‐heptadecylresorcinol (AR‐C17) has attracted increased attention due to its potential health‐improving activity. However, the beneficial effect of AR‐C17 on atherosclerosis prevention and the underlying mechanism remain unclear. METHODS ...
DOI:
10.1002/mnfr.202101114

37. A 5’-tiRNA fragment that inhibits proliferation and migration of laryngeal squamous cell carcinoma by targeting PIK3CD

Author:
Hongxia Deng; Jianing Wang; Dong Ye; Jingjing Chen; Shijie Qiu; Ming Tang; Chongchang Zhou; Yi Shen; Shuai Fang; Zhisen Shen; Shanshan Gu
Source:
Genomics 2022 v.114 no.4 pp. 110392
ISSN:
0888-7543
Subject:
apoptosis; biomarkers; carcinogenesis; cell growth; genomics; humans; larynx; lymph nodes; metastasis; phosphatidylinositol 3-kinase; protein subunits; squamous cell carcinoma
Abstract:
... tRNA-derived small RNAs (tsRNAs) participate in several biological processes, including carcinogenesis. The correlations between tsRNAs and human cancers are attracting substantial attention. Nevertheless, the involvement of tsRNAs in laryngeal squamous cell carcinoma (LSCC) progression remains unclear. We constructed tsRNAs expression profiles in LSCC and adjacent normal tissues by next-generatio ...
DOI:
10.1016/j.ygeno.2022.110392

38. 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats

Author:
Shu-Chieh Hu; Seonggi Min; Hyun-Ki Kang; Dong-Jin Yang; Mallikarjuna Basavarajappa; Sherry M. Lewis; Kelly J. Davis; Ralph E. Patton; Matthew S. Bryant; Estatira Sepehr; Raul Trbojevich; Mason G. Pearce; Michelle E. Bishop; Wei Ding; Robert H. Heflich; MacKean P. Maisha; Robert Felton; Susan Chemerynski; Steven B. Yee; Melis Coraggio; Hans Rosenfeldt; R. Philip Yeager; Paul C. Howard; Yunan Tang
Source:
Food and chemical toxicology 2022 v.160 pp. 112780
ISSN:
0278-6915
Subject:
DNA; aerosols; air; biomarkers; blood; body weight; bone marrow; breathing; carcinogenesis; carcinogenicity; cigarettes; comet assay; food consumption; genotoxicity; histopathology; humans; inhalation toxicity; lowest observed effect level; lungs; metabolites; mutagens; nitrosamines; no observed adverse effect level; nose; propylene glycol; urine
Abstract:
... 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. Repeated dose inhalation toxicity data on NNK, particularly relevant to cigarette smoking, however, is surprisingly limited. Hence, there is a lack of direct information available on the carcinogenic and potential non-carcinogenic effects o ...
DOI:
10.1016/j.fct.2021.112780

39. 96DRA-Urine: A high throughput sample preparation method for urinary proteome analysis

Author:
Xiaoyue Tang; Xiaoping Xiao; Haidan Sun; Shuxin Zheng; Xiaolian Xiao; Zhengguang Guo; Xiaoyan Liu; Wei Sun
Source:
Journal of proteomics 2022 v.257 pp. 104529
ISSN:
1874-3919
Subject:
acetone; alkylation; biomarkers; biomedical research; body fluids; digestion; mass spectrometry; peptides; proteome; proteomics; urinary bladder neoplasms; urine
Abstract:
... Mass spectrometry (MS)-based urinary proteomics is increasingly used for clinical research. A critical step in urinary proteomic analysis comprises the implementation of a reliable sample preparation method with high yields of peptides and proteins. In this study, we developed a urinary sample preparation method, DRA-Urine (Direct reduction/alkylation in urine), which urinary proteins were directl ...
DOI:
10.1016/j.jprot.2022.104529

40. An AC electrokinetics-based electrochemical aptasensor for the rapid detection of microRNA-155

Author:
Neil Adrian P. Ondevilla; Tak-Wah Wong; Nan-Yao Lee; Hsien-Chang Chang
Source:
Biosensors & bioelectronics 2022 v.199 pp. 113847
ISSN:
0956-5663
Subject:
aptasensors; biomarkers; blood serum; chemical species; detection limit; electric field; electrochemistry; electroosmosis; hybridization; immunosensors; oligonucleotides; rapid methods
Abstract:
... Traditional immunosensors are often limited by low sensitivity and long detection times, for they usually depend on passive diffusion-dominated transport of target analytes for the binding reaction with a bio-recognition element such as enzymes, antibodies, and aptamers. Numerous studies rely on electric field manipulation by using alternating current (AC) electrokinetics to enhance the hybridizat ...
DOI:
10.1016/j.bios.2021.113847

41. The AGE Reader: A non-invasive method to assess long-term tissue damage

Author:
I.M. Atzeni; S.C. van de Zande; J. Westra; J. Zwerver; A.J. Smit; D.J. Mulder
Source:
Methods 2022 v.203 pp. 533-541
ISSN:
1046-2023
Subject:
absorbance; acute course; advanced glycation end products; biomarkers; biopsy; cardiovascular diseases; clinical examination; diabetes; fluorescence; kidney diseases; melanin; oxidative stress; skin (animal); tissue degeneration
Abstract:
... Advanced glycation endproducts (AGEs) are sugar-modified adducts which arise during non-enzymatic glycoxidative stress. These compounds may become systemically elevated in disease states, and accumulate in tissue, especially on long-lived proteins. AGEs have been implicated in various acute, and chronic diseases, stressing the need for reliable and comprehensive measuring techniques. Measurement o ...
DOI:
10.1016/j.ymeth.2021.02.016

42. An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome

Author:
Lihe Sun; Juan Ouyang; Fang Zeng; Shuizhu Wu
Source:
Biomaterials 2022 v.283 pp. 121468
ISSN:
0142-9612
Subject:
autoimmune diseases; biocompatible materials; biomarkers; colon; drugs; fluorescence; inflammasomes; moieties; oral administration; pH; stomach; tomography; ulcerative colitis
Abstract:
... Ulcerative colitis is the most prevalent forms of inflammatory bowel diseases and a refractory autoimmune disease and affects millions of people worldwide. Herein, we develop an oral-administration nanosystem (QM@EP) for colitis detection, targeted drug delivery/release to colon and therapy. QM@EP consists of a molecular probe QY–SN–H₂O₂, a NLRP3 inhibitor MCC950 and enteric polymers. QY–SN–H₂O₂ i ...
DOI:
10.1016/j.biomaterials.2022.121468

43. APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b

Author:
Giulia Antoniali; Emiliano Dalla; Giovanna Mangiapane; Xiaolong Zhao; Xinming Jing; Yi Cheng; Veronica De Sanctis; Dilara Ayyildiz; Silvano Piazza; Mengxia Li; Gianluca Tell
Source:
Cellular and molecular life sciences 2022 v.79 no.8 pp. 446
ISSN:
1420-682X
Subject:
DNA repair; biogenesis; biomarkers; carcinogenesis; cell lines; cell proliferation; drug therapy; gene expression regulation; humans; lung neoplasms; microRNA; neoplasm cells
Abstract:
... Increasing evidence suggests different, not completely understood roles of microRNA biogenesis in the development and progression of lung cancer. The overexpression of the DNA repair protein apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is an important cause of poor chemotherapeutic response in lung cancer and its involvement in onco-miRNAs biogenesis has been recently described. Whether AP ...
DOI:
10.1007/s00018-022-04443-7

44. ARG1 as a promising biomarker for sepsis diagnosis and prognosis: evidence from WGCNA and PPI network

Author:
Jing-Xiang Zhang; Wei-Heng Xu; Xin-Hao Xing; Lin-Lin Chen; Qing-Jie Zhao; Yan Wang
Source:
Hereditas 2022 v.159 no.1 pp. 27
ISSN:
1601-5223
Subject:
bioinformatics; biomarkers; blood; data collection; gene expression regulation; genes; morbidity; mortality; prognosis; protein-protein interactions; quantitative polymerase chain reaction; septic shock
Abstract:
... BACKGROUND: Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated host response to infection. Sepsis remains a major global concern with high mortality and morbidity, while management of sepsis patients relies heavily on early recognition and rapid stratification. This study aims to identify the crucial genes and biomarkers for sepsis which could guide clinicians to make ...
DOI:
10.1186/s41065-022-00240-1

45. Absence of β-carotane as proxies of hydrothermal activity in brackish lacustrine sediments

Author:
Yuce Wang; Jian Cao; Keyu Tao; Wenyao Xiao; Baoli Xiang; Erting Li; Changchun Pan
Source:
Palaeogeography, palaeoclimatology, palaeoecology 2022 v.587 pp. 110801
ISSN:
0031-0182
Subject:
Permian period; biomarkers; geochemistry; palaeogeography; paleoclimatology; paleoecology; pyrite; sediment deposition; tuff; China
Abstract:
... β-Carotene, the precursor of β-carotane, is commonly rich in brackish sediments and would become unstable theoretically under the exposure to high temperatures, bright light conditions, and acidic or oxdizing environments. However, the specific process and mechanism of the absence of such compounds are still not clear sufficiently. To fill the knowledge gap, in this study we explore the origin of ...
DOI:
10.1016/j.palaeo.2021.110801

46. Accumulation of chemical elements and occurrence of microplastics in small pelagic fish from a neritic environment

Author:
Joana M. da Silva; Luís M.F. Alves; Maria I. Laranjeiro; Filipa Bessa; Andreia V. Silva; Ana C. Norte; Marco F.L. Lemos; Jaime A. Ramos; Sara C. Novais; Filipe R. Ceia
Source:
Environmental pollution 2022 v.292 pp. 118451
ISSN:
0269-7491
Subject:
Sardina pilchardus; Scomber; Trachurus trachurus; biomarkers; coasts; diet; habitat preferences; microplastics; oxidative stress; pelagic fish; pollution; stable isotopes; toxic substances; trophic levels
Abstract:
... The assessment of contaminant exposure in marine organisms often focuses on the most toxic chemical elements from upper trophic level species. Information on mid-trophic level species and particularly on potentially less harmful elements is lacking. Additionally, microplastics have been considered emergent contaminants in aquatic environments which have not been extensively studied in species from ...
DOI:
10.1016/j.envpol.2021.118451

47. Accuracy of different cutoffs of the waist‐to‐height ratio as a screening tool for cardiometabolic risk in children and adolescents: A systematic review and meta‐analysis of diagnostic test accuracy studies

Author:
Yasmin Ezzatvar; Mikel Izquierdo; Robinson Ramírez‐Vélez; Borja del Pozo Cruz; Antonio García‐Hermoso
Source:
Obesity reviews 2022 v.23 no.2 pp. e13375
ISSN:
1467-7881
Subject:
biomarkers; meta-analysis; obesity; risk; systematic review; waist-to-height ratio
Abstract:
... The present systematic review with meta‐analysis sought to estimate the accuracy of different waist‐to‐height ratio (WHtR) cutoff ranges as risk indicators for cardiometabolic health in different populations of children and adolescents. Systematic searches were undertaken to identify studies in apparently healthy participants aged 3–18 years that conducted receiver operating characteristic curve a ...
DOI:
10.1111/obr.13375

48. Accurate characterization of β-amyloid (Aβ40, Aβ42) standards using species-specific isotope dilution by means of HPLC-ICP-MS/MS

Author:
Martin Schaier; Gerrit Hermann; Gunda Koellensperger; Sarah Theiner
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.1 pp. 639-648
ISSN:
1618-2642
Subject:
amyloid; analytical chemistry; anion exchange; biomarkers; cysteic acid; cysteine; hydrolysates; hydrolysis; isotope dilution technique; lysozyme; methionine; myoglobin; oxidation; oxygen; peptides; sulfates; sulfur; yeasts
Abstract:
... The amyloid β peptide, as one of the main components in senile plaque, represents a defining pathological feature for Alzheimer’s disease, and is therefore commonly used as a biomarker for this disease in clinical analysis. However, the selection of suitable standards is limited here, since only a few are commercially available, and these suffer from varying purity. Hence, the accurate characteriz ...
DOI:
10.1007/s00216-021-03571-6

49. Acetylcholinesterase from the charru mussel Mytella charruana: kinetic characterization, physicochemical properties and potential as in vitro biomarker in environmental monitoring of mollusk extraction areas

Author:
Glauber Pereira Carvalho dos Santos; Caio Rodrigo Dias de Assis; Vagne Melo Oliveira; Thiago Barbosa Cahu; Valdir Luna Silva; Juliana Ferreira Santos; Gilvan Takeshi Yogui; Ranilson Souza Bezerra
Source:
Comparative biochemistry and physiology 2022 v.252 pp. 109225
ISSN:
1532-0456
Subject:
acetylcholinesterase; active sites; aldicarb; biomarkers; carbaryl; carbofuran; chlorpyrifos; cholinesterase; copper; cypermethrin; diazinon; dichlorvos; diflubenzuron; juvenile hormone analogs; mercury; mussels; novaluron; pH; parathion-methyl; physiology; pyrethrins; pyriproxyfen; temephos; thermal stability; zinc
Abstract:
... Acetylcholinesterase (AChE; EC 3.1.1.7) from aquatic organisms have been used to evaluate the exposure of specimens to pesticides and heavy metals at sublethal levels in environmental samples. AChE of Mytella charruana was extracted to characterize its physicochemical and kinetic properties as well as the effect of organophosphate (dichlorvos, diazinon, chlorpyrifos, methyl-parathion and temephos) ...
DOI:
10.1016/j.cbpc.2021.109225

50. Acoustofluidic multimodal diagnostic system for Alzheimer's disease

Author:
Nanjing Hao; Zeyu Wang; Pengzhan Liu; Ryan Becker; Shujie Yang; Kaichun Yang; Zhichao Pei; Peiran Zhang; Jianping Xia; Liang Shen; Lin Wang; Kathleen A. Welsh-Bohmer; Laurie H. Sanders; Luke P. Lee; Tony Jun Huang
Source:
Biosensors & bioelectronics 2022 v.196 no. pp. 113730
ISSN:
0956-5663
Subject:
Alzheimer disease; acoustics; biomarkers; brain; early diagnosis; electrochemistry; humans; immunoassays; immunosensors; microfluidic technology; nanorods; nanosilver; rapid methods; signal-to-noise ratio
Abstract:
... Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative brain disorder that affects tens of millions of older adults worldwide and has significant economic and societal impacts. Despite its prevalence and severity, early diagnosis of AD remains a considerable challenge. Here we report an integrated acoustofluidics-based diagnostic system (ADx), which combines triple functions ...
DOI:
10.1016/j.bios.2021.113730

51. Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-β1: A prospective cohort study

Author:
Bin Wang; Xing Wang; Linling Yu; Wei Liu; Jiahao Song; Lieyang Fan; Min Zhou; Meng Yang; Jixuan Ma; Man Cheng; Weihong Qiu; Ruyi Liang; Dongming Wang; Yanjun Guo; Weihong Chen
Source:
Environment international 2022 v.164 pp. 107261
ISSN:
0160-4120
Subject:
C-reactive protein; World Health Organization; acrylamides; adults; biomarkers; cardiovascular diseases; cohort studies; environment; inflammation; metabolites; oxidative stress; public health; risk
Abstract:
... Acrylamide (ACR) exposure and consequent health hazards are alarming public health issues that attract worldwide concern. The World Health Organization urges more researches into health hazards from ACR exposure. However, whether and how ACR exposure increases cardiovascular risk remain unclear, and we sought to address these issues in this prospective cohort study conducted on 3024 general adults ...
DOI:
10.1016/j.envint.2022.107261

52. Activatable Nanoprobe with Aggregation-Induced Dual Fluorescence and Photoacoustic Signal Enhancement for Tumor Precision Imaging and Radiotherapy

Author:
Meng Yuan; Xiao Fang; Ying Wu; Yuanji Xu; Hongjuan Feng; Jing Mu; Zhongxiang Chen; Yuhong Lin; Qinrui Fu; Wei Du; Huanghao Yang; Jibin Song
Source:
Analytical chemistry 2022 v.94 no.12 pp. 5204-5211
ISSN:
1520-6882
Subject:
X-radiation; absorption; analytical chemistry; biomarkers; cancer therapy; caspase-3; crosslinking; fluorescence; irradiation; nanogold; neoplasms; peptides; radiotherapy
Abstract:
... Owing to the high sensitivity and high spatial resolution, fluorescence (FL) imaging has been widely applied for visualizing biological processes. To gain insight into molecular events on deeper tissues, photoacoustic (PA) imaging with better deep-tissue imaging capability can be incorporated to provide complementary visualization and quantitative information on the pathological status. However, t ...
DOI:
10.1021/acs.analchem.2c00340

53. Activatable fluorescent probes for in situ imaging of enzymes

Author:
Xiaofeng Wu; Rui Wang; Nahyun Kwon; Huimin Ma; Juyoung Yoon
Source:
Chemical Society reviews 2022 v.51 no.2 pp. 450-463
ISSN:
1460-4744
Subject:
active sites; bioimaging; biomarkers; enzymes; fluorescence
Abstract:
... As the main biomarkers of most diseases, enzymes play fundamental but extremely critical roles in biosystems. High-resolution studies of enzymes using activatable in situ fluorescence imaging may help to better elucidate their dynamics in living systems. Currently, most activatable probes can realize changeable imaging of enzymes but inevitably tend to diffuse away from the original active site of ...
DOI:
10.1039/d1cs00543j

54. Active droplet-array microfluidics-based chemiluminescence immunoassay for point-of-care detection of procalcitonin

Author:
Enqi Huang; Dezhi Huang; Yu Wang; Dongyang Cai; Yanzhang Luo; Zhimin Zhong; Dayu Liu
Source:
Biosensors & bioelectronics 2022 v.195 pp. 113684
ISSN:
0956-5663
Subject:
automation; biomarkers; biosensors; chemiluminescence immunoassays; detection limit; disease detection; electrochemiluminescence; magnetism; microchip technology; organ-on-a-chip; point-of-care systems
Abstract:
... The application of conventional chemiluminescence immunoassay (CLIA) in resource-limited settings is limited due to the large apparatus footprint, cumbersome operation and maintenance process, and high consumption of reagents. To address this issue, we developed an active droplet-array (ADA) microfluidics-based CLIA system, which consists of a compact microchip analyzer and microfluidic chips with ...
DOI:
10.1016/j.bios.2021.113684

55. Activity of antioxidant enzymes in Mytilus galloprovincialis exposed to tar: Integrated response of different organs as pollution biomarker in aquaculture areas

Author:
Vladimir Dobal; Pilar Suárez; Yolanda Ruiz; Oscar García-Martín; Fuencisla San Juan
Source:
Aquaculture 2022 v.548 pp. 737638
ISSN:
0044-8486
Subject:
Mytilus galloprovincialis; analysis of variance; antioxidant activity; biomarkers; humans; indicator species; metabolism; mollusc culture; mussels; pollution; product quality; toxicology
Abstract:
... This paper analyses the antioxidant enzymes response of Mytilus galloprovincialis exposed to a tar mixture during a laboratory assay. These tar mixtures are generally used in the cleaning and waterproofing of the wooden rafts used in mussel culture, and are characterized by their high content in PAHs and transition metals. The punctual spillage of these mixtures around the rafts could cause mussel ...
DOI:
10.1016/j.aquaculture.2021.737638

56. Acupuncture Improves Heart Rate Variability, Oxidative Stress Level, Exercise Tolerance, and Quality of Life in Tracheal Collapse Dogs

Author:
Phurion Chueainta; Veerasak Punyapornwithaya; Weerapongse Tangjitjaroen; Wanpitak Pongkan; Chavalit Boonyapakorn
Source:
Veterinary sciences 2022 v.9 no.2 pp. -
ISSN:
2306-7381
Subject:
acupuncture; athletic performance; biomarkers; blood serum; dogs; exercise; heart rate; humans; malondialdehyde; oxidative stress; quality of life; questionnaires
Abstract:
... Among the respiratory disorders in dogs from small breeds, tracheal collapse is one of the most commonly found in clinical practice. Presently, acupuncture is widely used as an alternative treatment which was shown to bring about positive effects in the treatment of human respiratory diseases. The present study demonstrated the effect of acupuncture on tracheal collapse dogs. We hypothesized that ...
DOI:
10.3390/vetsci9020088

57. The Acute Effect of a Novel Miso-Type Sauce, Enhanced with a Carotenoid-Rich Extract from Fruit By-Products, on Postprandial Biomarkers of Oxidative Stress and Inflammation

Author:
Olga Papagianni; Eleni Delli; Melina-Eleni Vasila; Thomas Loukas; Athanasios Magkoutis; Charalampia Dimou; Haralampos C. Karantonis; Antonios E. Koutelidakis
Source:
Nutrients 2022 v.14 no.6 pp. -
ISSN:
2072-6643
Subject:
acute effects; antioxidant activity; biomarkers; blood serum; carotenoids; cross-over studies; fermentation; fluorescence recovery after photobleaching; fruit peels; fruits; glucose; inflammation; low density lipoprotein cholesterol; miso; oxidative stress; polyphenols; rice; uric acid
Abstract:
... Several fruit by-products may exert a beneficial role on oxidative stress and inflammation modulation, providing essential bioactive components, such as polyphenols and carotenoids. Recently, the potential bioactivity of miso has been reported. The aim of this dietary intervention–clinical study was to evaluate the acute effect of a novel, functional miso-type sauce based on legumes, on postprandi ...
DOI:
10.3390/nu14061316

58. Acute Exposure to Biogenic Nanosilver Produced from Fusarium oxysporum in a Neotropical Fish

Author:
Vanessa Bezerra; Wagner E. Risso; Claudia Bueno dos Reis Martinez; Juliana Delatim Simonato
Source:
Bulletin of environmental contamination and toxicology 2022 v.108 no.2 pp. 331-336
ISSN:
0007-4861
Subject:
Fusarium oxysporum; Neotropics; Prochilodus lineatus; acute exposure; antioxidant enzymes; biomarkers; brain; enzyme activity; erythrocytes; hyperglycemia; lipid peroxidation; liver; mutagens; nanosilver; neurotoxicity; oxidative stress; pollution; toxicology; tropical fish
Abstract:
... Biogenic nanosilver (bNAg) has emerged as a potentially less toxic alternative to synthetic nanosilver. However, no studies have evaluated its effects on a fish species from the Neotropical region. Thus, our aim was to evaluate the effects of a bNAg on the Neotropical fish Prochilodus lineatus. For this purpose, after 24 h of exposure to 100 µg L⁻¹ of bNAg, blood samples were collected to evaluate ...
DOI:
10.1007/s00128-021-03397-z

59. Acute exposure to 17-α-ethinylestradiol disrupt the embryonic development and oxidative status of Danio rerio

Author:
María del Carmen Ramírez-Montero; Leobardo Manuel Gómez-Oliván; Verónica Margarita Gutiérrez-Noya; José Manuel Orozco-Hernández; Hariz Islas-Flores; Gustavo Axel Elizalde-Velázquez; Nely SanJuan-Reyes; Marcela Galar-Martínez
Source:
Comparative biochemistry and physiology 2022 v.251 pp. 109199
ISSN:
1532-0456
Subject:
Danio rerio; abnormal development; acute exposure; biomarkers; catalase; embryogenesis; estradiol; fish; glutathione peroxidase; lipid peroxidation; oxidative stress; sex determination; sexual maturity; superoxide dismutase; teratogenicity; toxic substances
Abstract:
... 17-Alpha-ethinylestradiol (EE2) is an estrogen derived from estradiol (E2). This compound and is one of the most widely used drugs both in humans and animals. Numerous studies have reported the ability of EE2 to alter sex determination and delay sexual maturity, but there are toxic effects that need to be explored. In this work, we analyzed the effect of EE2 on embryonic development and oxidative ...
DOI:
10.1016/j.cbpc.2021.109199

60. Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos

Author:
Jesús Daniel Cardoso-Vera; Leobardo Manuel Gómez-Oliván; Hariz Islas-Flores; Sandra García-Medina; José Manuel Orozco-Hernández; Gerardo Heredia-García; Gustavo Axel Elizalde-Velázquez; Marcela Galar-Martínez; Nely SanJuan-Reyes
Source:
Comparative biochemistry and physiology 2022 v.253 pp. 109265
ISSN:
1532-0456
Subject:
Danio rerio; abnormal development; acute exposure; aquatic organisms; biomarkers; deformation; early development; embryogenesis; enzyme activity; hospitals; industrial effluents; lipid peroxidation; oxidative stress; phenytoin; tail; toxicity
Abstract:
... Phenytoin (PHE) is an antiepileptic drug that has been widely used in clinical practice for about 80 years. It is mainly used in the treatment of tonic-clonic and partial seizures. The widespread consumption of this drug around the world has led to PHE being introduced into water bodies through municipal, hospital, and industrial effluent discharges. Since the toxic effects of this drug on aquatic ...
DOI:
10.1016/j.cbpc.2021.109265

61. Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae boulardii: a metabolomics approach

Author:
Junjie Fu; Chaolan Liu; Li Li; Jun Liu; Yu Tie; Xueping Wen; Qikai Zhao; Zongwei Qiao; Zheming An; Jia Zheng
Source:
International journal of food science & technology 2022 v.57 no.5 pp. 2918-2931
ISSN:
0950-5423
Subject:
Saccharomyces cerevisiae var. cerevisiae; acetic acid; acid tolerance; biomarkers; biomass production; butyric acid; fermentation; food science; fructose; glycolysis; lactic acid; mannose; metabolites; metabolomics; probiotics; tricarboxylic acid cycle
Abstract:
... Weak acids inhibit the growth of probiotics, such as Saccharomyces boulardii. We explored the tolerance of S. boulardii to different weak acids. S. boulardii had better fermentation ability under lactic acid conditions compared with acetic and butyric acid conditions; however, the budding of S. boulardii was significantly stronger than that of Saccharomyces cerevisiae under acetic acid conditions. ...
DOI:
10.1111/ijfs.15598

62. Addressing Missing Data in GC × GC Metabolomics: Identifying Missingness Type and Evaluating the Impact of Imputation Methods on Experimental Replication

Author:
Trenton J. Davis; Tarek R. Firzli; Emily A. Higgins Keppler; Matthew Richardson; Heather D. Bean
Source:
Analytical chemistry 2022 v.94 no.31 pp. 10912-10920
ISSN:
1520-6882
Subject:
Bayesian theory; analytical chemistry; biomarkers; comprehensive two-dimensional gas chromatography; metabolomics; principal component analysis; regression analysis
Abstract:
... Missing data is a significant issue in metabolomics that is often neglected when conducting data preprocessing, particularly when it comes to imputation. This can have serious implications for downstream statistical analyses and lead to misleading or uninterpretable inferences. In this study, we aim to identify the primary types of missingness that affect untargeted metabolomics data and compare s ...
DOI:
10.1021/acs.analchem.1c04093

63. Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author:
Vasileios C. Pezoulas; Andreas Goules; Fanis Kalatzis; Luke Chatzis; Konstantina D. Kourou; Aliki Venetsanopoulou; Themis P. Exarchos; Saviana Gandolfo; Konstantinos Votis; Evi Zampeli; Jan Burmeister; Thorsten May; Manuel Marcelino Pérez; Iryna Lishchuk; Thymios Chondrogiannis; Vassiliki Andronikou; Theodora Varvarigou; Nenad Filipovic; Manolis Tsiknakis; Chiara Baldini; Michele Bombardieri; Hendrika Bootsma; Simon J. Bowman; Muhammad Shahnawaz Soyfoo; Dorian Parisis; Christine Delporte; Valérie Devauchelle-Pensec; Jacques-Olivier Pers; Thomas Dörner; Elena Bartoloni; Roberto Gerli; Roberto Giacomelli; Roland Jonsson; Wan-Fai Ng; Roberta Priori; Manuel Ramos-Casals; Kathy Sivils; Fotini Skopouli; Witte Torsten; Joel A. G. van Roon; Mariette Xavier; Salvatore De Vita; Athanasios G. Tzioufas; Dimitrios I. Fotiadis
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 471-484
ISSN:
2001-0370
Subject:
biomarkers; biotechnology; data analysis; ethics; lymphoma
Abstract:
... For many decades, the clinical unmet needs of primary Sjögren’s Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the pSS-associated lymphomagenesis process. Here, we present the HarmonicSS cloud-computing exemplar which offers beyond the state-of-the-art data analytics services to address the pSS clini ...
DOI:
10.1016/j.csbj.2022.01.002

64. Adiponectin-targeted SERS immunoassay biosensing platform for early detection of gestational diabetes mellitus

Author:
Wansun Kim; Ayoung Bang; Soogeun Kim; Gi-Ja Lee; Yeon-Hee Kim; Samjin Choi
Source:
Biosensors & bioelectronics 2022 v.213 pp. 114488
ISSN:
0956-5663
Subject:
adiponectin; anisotropy; biomarkers; biosensors; detection limit; finite element analysis; gestational diabetes; gold; heat; immunoassays; pregnancy; purification methods; surface plasmon resonance; thiols; wavelengths
Abstract:
... The anisotropic gold nanotriangles (AuNTs) were synthesized by a fast seedless growth process. The high-yield monodispersed AuNT colloids were obtained through a purification process based on depletion-induced interactions. AuNTs were modulated with a localized surface plasmon resonance (LSPR) peak of 638 nm wavelength coherent with the Raman excitation light. However, from finite element computat ...
DOI:
10.1016/j.bios.2022.114488

65. Adolescents’ dietary polyphenol intake in relation to serum total antioxidant capacity: the HELENA study

Author:
Ratih W. Wisnuwardani; Stefaan De Henauw; Maria Forsner; Frédéric Gottrand; Inge Huybrechts; Antonios G. Kafatos; Mathilde Kersting; Viktoria Knaze; Yannis Manios; Esther Nova; Dénes Molnár; Joseph A. Rothwell; Augustin Scalbert; Stefania Sette; Kurt Widhalm; Luis A. Moreno; Nathalie Michels
Source:
International journal of food sciences and nutrition 2022 v.73 no.1 pp. 71-81
ISSN:
1465-3478
Subject:
antioxidant activity; antioxidants; biomarkers; blood serum; databases; nutrition; overweight; polyphenols
Abstract:
... We evaluated the association between intake of total polyphenols, polyphenol classes and the 10 most consumed individual polyphenols with serum total antioxidant capacity (TAC) in 749 European adolescents (53% girls; 15% overweight; 12.5–17.5 years-old) from the cross-sectional HELENA study of 2006–2007. Dietary polyphenol intake was calculated from two non-consecutive 24-h recalls matched with th ...
DOI:
10.1080/09637486.2021.1910631

66. Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines

Author:
Haiyan Jiang; Yaxin Zhang; Zhigang Liu; Xiangyi Wang; Jiuming He; Hongtao Jin
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114760
ISSN:
0378-8741
Subject:
COVID-19 infection; biomarkers; chemical analysis; chemometrics; humans; liquid chromatography; mass spectrometry; quality control; therapeutics; toxicity; toxicology; China
Abstract:
... Traditional Chinese medicines (TCMs) have made great contributions to the prevention and treatment of human diseases in China, and especially in cases of COVID-19. However, due to quality problems, the lack of standards, and the diversity of dosage forms, adverse reactions to TCMs often occur. Moreover, the composition of TCMs makes them extremely challenging to extract and isolate, complicating s ...
DOI:
10.1016/j.jep.2021.114760

67. Advanced detection and sensing strategies of Pseudomonas aeruginosa and quorum sensing biomarkers: A review

Author:
Yingying Li; Yang Hu; Tao Chen; Yan Chen; Yi Li; Haibo Zhou; Danting Yang
Source:
Talanta 2022 v.240 pp. 123210
ISSN:
0039-9140
Subject:
Pseudomonas aeruginosa; Raman spectroscopy; antibiotic resistance; biomarkers; cross infection; cystic fibrosis; electrochemistry; equipment; fluorescence; morbidity; mortality; opportunistic pathogens; polymerase chain reaction; rapid methods; sorbents; surface plasmon resonance
Abstract:
... Pseudomonas aeruginosa (P. aeruginosa), a ubiquitous opportunistic pathogen, can frequently cause chronic obstructive pulmonary disease, cystic fibrosis and chronic wounds, and potentially lead to severe morbidity and mortality. Timely and adequate treatment of nosocomial infection in clinic depends on rapid detection and accurate identification of P. aeruginosa and its early-stage antibiotic susc ...
DOI:
10.1016/j.talanta.2022.123210

68. Advanced glycation end products in musculoskeletal system and disorders

Author:
Akinobu Suzuki; Akito Yabu; Hiroaki Nakamura
Source:
Methods 2022 v.203 pp. 179-186
ISSN:
1046-2023
Subject:
biomarkers; biomechanics; cartilage; chromatography; diabetes; elderly; fluorescence; glucose; human population; inflammation; mass spectrometry; osteoarthritis; osteoporosis; peripheral nervous system diseases; quality of life; sarcopenia; signal transduction; therapeutics
Abstract:
... The human population is ageing globally, and the number of old people is increasing yearly. Diabetes is common in the elderly, and the number of diabetic patients is also increasing. Elderly and diabetic patients often have musculoskeletal disorder, which are associated with advanced glycation end products (AGEs). AGEs are heterogeneous molecules derived from non-enzymatic products of the reaction ...
DOI:
10.1016/j.ymeth.2020.09.012

69. Advanced glycation end products via skin autofluorescence as a new biomarker for major adverse cardiovascular events: A meta-analysis of prospective studies

Author:
Qimou Chen; Qiaojuan Huang; Weiwei Liu; Xiaoli Zhou
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.5 pp. 1083-1092
ISSN:
0939-4753
Subject:
biomarkers; cardiovascular diseases; diabetes; kidney diseases; meta-analysis; metabolism; nutrition; risk
Abstract:
... This meta-analysis aimed to systematically evaluate the prospective association between advanced glycation end products (AGEs) and major adverse cardiovascular events (MACE). Prospective studies that reported the association of AGEs (measured by skin autofluorescence) with MACE were searched in PubMed and EMBASE from inception up to July 2021. Multivariable-adjusted hazard ratios (HRs) and their r ...
DOI:
10.1016/j.numecd.2022.01.032

70. Advanced glycation end products, leukocyte telomere length, and mitochondrial DNA copy number in patients with coronary artery disease and alterations of glucose homeostasis: From the GENOCOR study

Author:
Cecilia Vecoli; Giuseppina Basta; Andrea Borghini; Melania Gaggini; Serena Del Turco; Antonella Mercuri; Amalia Gastaldelli; Maria Grazia Andreassi
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.5 pp. 1236-1244
ISSN:
0939-4753
Subject:
biomarkers; coronary artery disease; diabetes; glucose; hazard characterization; homeostasis; leukocytes; metabolism; mitochondrial DNA; nutrition; risk; telomeres
Abstract:
... Alterations of glucose homeostasis can increase advanced glycation end products (AGEs) that exacerbate vascular inflammatory disease and may increase vascular senescence and aging. This study examined the relationships between carboxymethyl-lysine (CML) and soluble receptor for AGEs (sRAGE) with leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn), as cell aging biomarkers, ...
DOI:
10.1016/j.numecd.2022.01.021

71. Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis

Author:
Yuning Wang; Bin Li; Tongtong Tian; Yujie Liu; Juxiang Zhang; Kun Qian
Source:
Trends in analytical chemistry 2022 v.149 pp. 116565
ISSN:
0165-9936
Subject:
analytical chemistry; biomarkers; biosensors; early diagnosis; electrochemistry; exosomes; fluorescence; mass spectrometry; metabolites; neoplasms
Abstract:
... Point-of-care testing (POCT), as one part of in vitro diagnostic (IVD), has been gradually used in early diagnosis and personalized treatment in the clinics. Accurate and sensitive detection of clinically related biomarkers is valuable, especially using the methods with simple, rapid, high throughput, miniaturization, and low cost. Nowadays, various biomolecules have been regarded as biomarkers fo ...
DOI:
10.1016/j.trac.2022.116565

72. Advancement in oil forensics through the addition of polycyclic aromatic sulfur heterocycles as biomarkers in diagnostic ratios

Author:
Taylor Filewood; Honoria Kwok; Pamela Brunswick; Jeffrey Yan; Jessica E. Ollinik; Christopher Cote; Marcus Kim; Graham van Aggelen; Caren C. Helbing; Dayue Shang
Source:
Journal of hazardous materials 2022 v.435 pp. 129027
ISSN:
0304-3894
Subject:
biomarkers; forensic sciences; gas chromatography; heterocyclic compounds; mass spectrometry; oil spills; oils; petroleum; sulfur
Abstract:
... In current oil spill forensics, diagnostic ratios of hydrocarbon biomarker responses are commonly used to compare oil spill samples to source materials in order to determine the identity of the oil. This well recognized procedure was developed by the European Committee for Standardization (CEN) with corresponding published EN 15522–2 Oil Spill Identification guidelines. However, it is further reco ...
DOI:
10.1016/j.jhazmat.2022.129027

73. Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices

Author:
Kaitlynn R. Mitchell; Joule E. Esene; Adam T. Woolley
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.1 pp. 167-180
ISSN:
1618-2642
Subject:
analytical chemistry; biomarkers; cost effectiveness; diagnostic techniques; mobile telephones; point-of-care systems; risk assessment; spectroscopy
Abstract:
... Microfluidic devices can provide a versatile, cost-effective platform for disease diagnostics and risk assessment by quantifying biomarkers. In particular, simultaneous testing of several biomarkers can be powerful. Here, we critically review work from the previous 4 years up to February 2021 on developing microfluidic devices for multiplexed detection of biomarkers from samples. We focus on two p ...
DOI:
10.1007/s00216-021-03553-8

74. Advances in nanosensors for cardiovascular disease detection

Author:
Xiaofang Tang; Yaping Zhu; Weijiang Guan; Wenjuan Zhou; Peifa Wei
Source:
Life sciences 2022 v.305 pp. 120733
ISSN:
0024-3205
Subject:
biomarkers; cardiovascular diseases; disease detection; electrochemistry; morbidity; mortality; prediction; sensors (equipment)
Abstract:
... Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality around the world. The physiological or pathological processes of CVDs can be well indicated by timely and accurate diagnosis of relevant biomarkers and function parameters. Nanosensors integrating the advantages of nanomaterials and sensing platforms have shown good potential for rapid diagnosis of CVDs, especially for e ...
DOI:
10.1016/j.lfs.2022.120733

75. Advances in nucleic acids-scaffolded electrical sensing of extracellular vesicle biomarkers

Author:
Ting-Ting Liang; Xiaoling Qin; Yuanhang Xiang; Yujin Tang; Fan Yang
Source:
Trends in analytical chemistry 2022 v.148 pp. 116532
ISSN:
0165-9936
Subject:
DNA; analytical chemistry; biomarkers; biomimetics; electrochemistry; transistors
Abstract:
... Extracellular vesicles (EVs) are emerging as biomarkers by inheriting biomolecular information from their parental cells. They are highly heterogeneous and can reflect the status of diseases, like cancer. These features intrigue intense interest in EVs-oriented bioanalysis with different detection technologies and bioprobes for noninvasive diagnosis. In this review, we summarize the recent advance ...
DOI:
10.1016/j.trac.2022.116532

76. Advances in quantifying circulatory microRNA for early disease detection

Author:
Jit Kong Cheong; Yew Chung Tang; Lihan Zhou; He Cheng; Heng-Phon Too
Source:
Current opinion in biotechnology 2022 v.74 pp. 256-262
ISSN:
0958-1669
Subject:
biomarkers; biopsy; biotechnology; diagnostic techniques; disease detection; excreta; microRNA; patients; precision medicine
Abstract:
... Precision preventive healthcare aims to improve patient health by integrating preventive measures with early disease detection for timely intervention with precision medicine. Key to the delivery of preventive healthcare is the clinical adoption of novel assays that enable early disease detection. Such assays, typically based on biomarkers such as microRNAs (miRNAs) from liquid biopsy or excreta, ...
DOI:
10.1016/j.copbio.2021.12.007

77. Advances in surface plasmon resonance–based biosensor technologies for cancer biomarker detection

Author:
Abdelmonaim Azzouz; Lamia Hejji; Ki-Hyun Kim; Deepak Kukkar; Badredine Souhail; Neha Bhardwaj; Richard J.C. Brown; Wei Zhang
Source:
Biosensors & bioelectronics 2022 v.197 pp. 113767
ISSN:
0956-5663
Subject:
biomarkers; biosensors; breasts; detection limit; early diagnosis; lungs; neoplasm progression; quality control; surface plasmon resonance
Abstract:
... Surface plasmon resonance approach is a highly useful option to offer optical and label-free detection of target bioanalytes with numerous advantages (e.g., low-cost fabrication, appreciable sensitivity, label-free detection, and outstanding accuracy). As such, it allows early diagnosis of cancer biomarkers to monitor tumor progression and to prevent the recurrence of oncogenic tumors. This work h ...
DOI:
10.1016/j.bios.2021.113767

78. Advances in the complement system of a teleost fish, Oreochromisniloticus

Author:
Lorena Bavia; Lazara Elena Santiesteban-Lores; Milena Carvalho Carneiro; Maritana Mela Prodocimo
Source:
Fish & shellfish immunology 2022 v.123 pp. 61-74
ISSN:
1050-4648
Subject:
Oreochromis niloticus; biomarkers; complement; ecotoxicology; evolution; fish; health status; immune system; lectins; models; shellfish; water quality
Abstract:
... As the earliest known vertebrate possessing a complete immune system, teleost fish played an important role in the evolution of this system. The complement system is an ancient defense mechanism present in invertebrates and vertebrates. In teleost fish the complement system is formed by more than 35 circulating proteins, or found at the cell surface. This system is activated by three pathways: alt ...
DOI:
10.1016/j.fsi.2022.02.013

79. Advances in the enzymatic biofuel cell powered sensing systems for tumor diagnosis and regulation

Author:
Linlin Wang; Jian-Rong Zhang; Xiaoge Wu; Jun-Jie Zhu
Source:
Trends in analytical chemistry 2022 v.146 pp. 116476
ISSN:
0165-9936
Subject:
analytical chemistry; biofuels; biomarkers; biosensors; chemical species; human health; microbial fuel cells; neoplasms; therapeutics
Abstract:
... Tumors are the leading killers of human health, however, diagnosis on tumors are neither timely nor accurate due to the high detection cost and high technical requirements. For cancer diagnosis and treatment, self-powered biosensors based on enzymatic biofuel cells have the advantages of simple structure, easy miniaturization, instantaneous response to analytes, and high economic applicability. It ...
DOI:
10.1016/j.trac.2021.116476

80. Advantages of optical fibers for facile and enhanced detection in droplet microfluidics

Author:
Sundar Hengoju; Oksana Shvydkiv; Miguel Tovar; Martin Roth; Miriam A. Rosenbaum
Source:
Biosensors & bioelectronics 2022 v.200 pp. 113910
ISSN:
0956-5663
Subject:
absorbance; biomarkers; biosensors; biotechnology; chemical species; diagnostic techniques; droplets; drugs; fluorescence; microfluidic technology; nucleic acids; optical fibers; point-of-care systems
Abstract:
... Droplet microfluidics offers a unique opportunity for ultrahigh-throughput experimentation with minimal sample consumption and thus has obtained increasing attention, particularly for biological applications. Detection and measurements of analytes or biomarkers in tiny droplets are essential for proper analysis of biological and chemical assays like single-cell studies, cytometry, nucleic acid det ...
DOI:
10.1016/j.bios.2021.113910

81. Adverse effects of dietary virgin (nano)microplastics on growth performance, immune response, and resistance to ammonia stress and pathogen challenge in juvenile sea cucumber Apostichopus japonicus (Selenka)

Author:
Ji Liu; Dongxue Xu; Yanru Chen; Chunyan Zhao; Lanhao Liu; Yuanxue Gu; Yichao Ren; Bin Xia
Source:
Journal of hazardous materials 2022 v.423 pp. 127038
ISSN:
0304-3894
Subject:
Apostichopus japonicus; acclimation; ammonia; biomarkers; diet; growth performance; immune response; juveniles; malondialdehyde; nanoplastics; oxidative stress; pathogens; polystyrenes; reactive oxygen species; risk; specific growth rate; toxicity
Abstract:
... It has been well documented that micro- and nanoplastics are emerging pollutants in aquatic environments, and their potential toxic effects has attracted widespread concerns. Here, we evaluated the adverse effects of dietary polystyrene nanoplastics and microplastics (PS-N/MPs) on growth performance, oxidative stress induction, immune response, ammonia detoxification, and bacterial pathogen resist ...
DOI:
10.1016/j.jhazmat.2021.127038

82. Adverse physiologic effects of a common food additive potassium metabisulfite (E224) in laboratory rats

Author:
Irfan Zia Qureshi; Nizam Ud Din; Ghulam Khadija; Aneeqa Shahzadi; Bakhtawer Rafiq; Hina Afaqi
Source:
Journal of food processing and preservation 2022 v.46 no.3 pp. e16393
ISSN:
0145-8892
Subject:
biomarkers; body weight; brain; catalase; dose response; food preservatives; glutathione; histology; kidneys; liver; males; oral exposure; oxidative stress; peroxidase; potassium metabisulfite; protein content; reactive oxygen species; superoxide dismutase; toxicity
Abstract:
... Current study investigated the effects of potassium metabisulfite (E224), a common food preservative, in male rats following 28 days of oral exposure at doses: 0.7, 7.0, and 70 mg/kg b.w. Following autopsies, blood and tissues samples (liver, kidney, brain, and testes) were taken. Data were compared statistically at p < .05. Potassium metabisulfite caused significant dose‐dependent reduction in mo ...
DOI:
10.1111/jfpp.16393

83. Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women

Author:
Marwa M. Elsayed; Ghada E. El Refaye; Ahmed Rabiee; Sameh Abouzeid; Hany F. Elsisi
Source:
Heliyon 2022 v.8 no.3 pp. e09165
ISSN:
2405-8440
Subject:
biomarkers; blood serum; diet; dietary restriction; exercise; human health; insulin resistance; lifestyle; postmenopause; therapeutics
Abstract:
... Physical activity and diet are recommended lifestyle strategies to improve human health. Consequently, this study aimed to investigate the impact of aerobic exercise combined with dietary restriction on hormonal, metabolic, and psychological variables in postmenopausal women. Eligible 60 women were enrolled and assigned into two equal groups; the experimental group performed aerobic exercise three ...
DOI:
10.1016/j.heliyon.2022.e09165

84. Affimer sandwich probes for stable and robust lateral flow assaying

Author:
Garima Goyal; Antareep Sharma; Alfred Iing Yoong Tok; Alagappan Palaniappan; Bo Liedberg
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.14 pp. 4245-4254
ISSN:
1618-2642
Subject:
ambient temperature; analytical chemistry; biomarkers; cold storage; humans; interleukin-8; shelf life; thermal stability
Abstract:
... Lateral flow assays (LFAs) widely deployed for on-site diagnosis have predominantly utilized antibodies as recognition molecules. Antibodies with limited thermal stability deteriorate the performance of the LFA over time. Herein, we demonstrate a stable and robust LFA by utilizing thermally stable peptide-based 12–14 kDa affimers as recognition molecules, in lieu of conventional protein-based anti ...
DOI:
10.1007/s00216-022-04078-4

85. Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer

Author:
Lidija Filipović; Milica Spasojević; Radivoje Prodanović; Aleksandra Korać; Suzana Matijaševic; Goran Brajušković; Ario de Marco; Milica Popović
Source:
New biotechnology 2022 v.69 pp. 36-48
ISSN:
1871-6784
Subject:
biomarkers; biotechnology; cell culture; chromatography; composite polymers; culture media; exosomes; fractionation; humans; lipoproteins; porous media
Abstract:
... Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purifi ...
DOI:
10.1016/j.nbt.2022.03.001

86. Ag nanoparticles outperform Au nanoparticles for the use as label in electrochemical point-of-care sensors

Author:
Franziska Beck; Carina Horn; Antje J. Baeumner
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.1 pp. 475-483
ISSN:
1618-2642
Subject:
analytical chemistry; antibodies; biomarkers; blood proteins; blood serum; detection limit; dose response; electrochemistry; humans; immunoassays; immunosensors; nanogold; nanosilver; oxidation; point-of-care systems; standard deviation; storage quality; voltammetry
Abstract:
... Electrochemical immunosensors enable rapid analyte quantification in small sample volumes, and have been demonstrated to provide high sensitivity and selectivity, simple miniaturization, and easy sensor production strategies. As a point-of-care (POC) format, user-friendliness is equally important and most often not combinable with high sensitivity. As such, we demonstrate here that a sequence of m ...
DOI:
10.1007/s00216-021-03288-6

87. Age‐related changes in thyroid hormones, some serum oxidative biomarkers and trace elements and their relationships in healthy Saanen goat kids during the first three month of age

Author:
Elham Valavi; Mahdieh Zaeemi; Mehrdad Mohri
Source:
Journal of animal physiology and animal nutrition 2022 v.106 no.3 pp. 494-505
ISSN:
0931-2439
Subject:
Saanen; animal nutrition; animal physiology; antioxidant activity; antioxidants; biomarkers; blood serum; financial economics; glutathione; livestock production; malondialdehyde; neonates; oxidative stress
Abstract:
... BACKGROUND: Early‐life diseases in dairy animals are main causes of economic loss in livestock production. Oxidative stress (OS) and thyroid hormones are important inter‐related components in the normal physiology of this critical period of life. However, limited information regarding their physiology in goat kids is available. This study was conducted to investigate the age‐related changes of thy ...
DOI:
10.1111/jpn.13634

88. Air pollution and metabolic disorders: Dynamic versus static measures of exposure among Hispanics/Latinos and non-Hispanics

Author:
Noémie Letellier; Steven Zamora; Chad Spoon; Jiue-An Yang; Marion Mortamais; Gabriel Carrasco Escobar; Dorothy D. Sears; Marta M. Jankowska; Tarik Benmarhnia
Source:
Environmental research 2022 v.209 pp. 112846
ISSN:
0013-9351
Subject:
Latinos; air pollution; biomarkers; cholesterol; cross-sectional studies; diabetes; equations; exposure assessment; hyperlipidemia; hypertension; insulin resistance; metabolic syndrome; obesity; research; risk; space and time; traffic
Abstract:
... Exposure to air pollution disproportionately affects racial/ethnic minorities that could contribute to health inequalities including metabolic disorders. However, most existing studies used a static assessment of air pollution exposure (mostly using the residential address) and do not account for activity space when modelling exposure to air pollution. The aim of this study is to understand how ex ...
DOI:
10.1016/j.envres.2022.112846

89. Airway inflammation in adolescents and elderly women: Chronic air pollution exposure and polygenic susceptibility

Author:
Sara Kress; Anna Kilanowski; Claudia Wigmann; Qi Zhao; Tianyu Zhao; Michael J. Abramson; Monika Gappa; Marie Standl; Klaus Unfried; Tamara Schikowski
Source:
Science of the total environment 2022 v.841 pp. 156655
ISSN:
0048-9697
Subject:
air pollutants; air pollution; biomarkers; elderly; environment; genotype-environment interaction; inflammation; land use; nitric oxide; nitrogen dioxide; regression analysis; risk
Abstract:
... The fractional exhaled nitric oxide (FeNO) concentration in the exhaled breath is a biomarker for eosinophilic airway inflammation. We explored the interplay between chronic air pollution exposure and polygenic susceptibility to airway inflammation at different critical age stages. Adolescents (15 yr) enrolled in the GINIplus/LISA birth cohorts (n = 2434) and 220 elderly women (75 yr on average) e ...
DOI:
10.1016/j.scitotenv.2022.156655

90. Airway smooth muscle remodelling in mild and moderate equine asthma

Author:
Florence Dupuis‐Dowd; Jean‐Pierre Lavoie
Source:
Equine veterinary journal 2022 v.54 no.5 pp. 865-874
ISSN:
0425-1644
Subject:
asthma; biomarkers; case-control studies; cell proliferation; horses; hospitals; hyperplasia; hypertrophy; immunohistochemistry; inflammation; myocytes; myosin heavy chains; smooth muscle
Abstract:
... BACKGROUND: Airway smooth muscle remodelling in severe equine asthma includes both thickening of airway smooth muscle, resulting from hyperplasia and hypertrophy, and changes in contractility. However, airway smooth muscle changes have not been studied in milder forms of the disease. OBJECTIVES: To investigate bronchial smooth muscle remodelling in horses with mild and moderate asthma (MEA). STUDY ...
DOI:
10.1111/evj.13514

91. Alcohol Consumption and Its Influence on the Clinical Picture of Puumala Hantavirus Infection

Author:
Laura Tervo; Tuula K. Outinen; Satu Mäkelä; Jenna Mustalahti; Heini Huhtala; Ilkka Pörsti; Jaana Syrjänen; Jukka T. Mustonen; Onni Niemelä
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Hantaviridae infections; Orthohantavirus; acute kidney injury; alanine transaminase; alcohol drinking; alcohols; amylases; biomarkers; blood serum; disease course; fever; gamma-glutamyltransferase; liver; pancreatitis; risk; thrombocytopenia; transferrin
Abstract:
... Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a more severe infection. Liver and pancreatic enzymes, as well as biomarkers of alcohol consumption (gamm ...
DOI:
10.3390/v14030500

92. All-in-One Strategy for Downstream Molecular Profiling of Tumor-Derived Exosomes

Author:
Shurong Wang; Ying He; Jiayin Lu; Yuqing Wang; Xiaofeng Wu; Guoquan Yan; Xiaoni Fang; Baohong Liu
Source:
ACS applied materials & interfaces 2022 v.14 no.32 pp. 36341-36352
ISSN:
1944-8252
Subject:
biomarkers; cell culture; cost effectiveness; culture media; exosomes; hydrophilicity; nanopores; proteolysis; proteomics; stomach neoplasms
Abstract:
... In light of the significance of exosomes in cancer diagnosis and treatment, it is important to understand the components and functions of exosomes. Herein, an all-in-one strategy has been proposed for comprehensive characterization of exosomal proteins based on nanoporous TiO₂ clusters acting as both an extractor for exosome isolation and a nanoreactor for downstream molecular profiling. With the ...
DOI:
10.1021/acsami.2c07143

93. Alleviation of cadmium phytotoxicity in triacontanol treated Coriandrum sativum L. by modulation of physiochemical attributes, oxidative stress biomarkers and antioxidative system

Author:
Rehana Sardar; Shakil Ahmed; Muhammad Akbar; Nasim Ahmad Yasin; Guihua Li
Source:
Chemosphere 2022 v.295 pp. 133924
ISSN:
0045-6535
Subject:
Coriandrum sativum; biomarkers; catalase; chlorophyll; electrolyte leakage; flavonoids; growth retardation; hydrogen peroxide; lipid peroxidation; oxidative stress; peroxidase; phenolic compounds; photosynthesis; phytotoxicity; proline; risk; soil; triacontanol
Abstract:
... Cadmium (Cd) is a hazardous metal that has a significant risk of transfer from soil to edible parts of food crops including shoots and seeds. Reduction of Cd accumulation is required to lower the risk of Cd exposure in humans and animals feeding on metal contaminated parts of such plants. Coriandrum sativum L. (coriander) exposed to Cd showed stress symptoms such as stunted growth, reduced photosy ...
DOI:
10.1016/j.chemosphere.2022.133924

94. Allopurinol Lowers Serum Urate but Does Not Reduce Oxidative Stress in CKD

Author:
Mingyao Sun; Nicole Hines; Diego Scerbo; Jane Buchanan; Chaorong Wu; Patrick Ten Eyck; Diana Zepeda-Orozco; Eric B. Taylor; Diana I. Jalal
Source:
Antioxidants 2022 v.11 no.7 pp. -
ISSN:
2076-3921
Subject:
allopurinol; biomarkers; blood serum; clinical trials; fluorescent antibody technique; gas chromatography-mass spectrometry; gout; hyperuricemia; kidney diseases; metabolome; metabolomics; oxidative stress; pentoses; phosphates; placebos; protein synthesis; risk; tyrosine; xanthine; xanthine oxidase
Abstract:
... Xanthine oxidase (XO) contributes to oxidative stress and vascular disease. Hyperuricemia and gout are common in patients with chronic kidney disease (CKD), a population at increased risk of vascular disease. We evaluated effects of allopurinol on serum XO activity and metabolome of CKD patients who had participated in a randomized double-blind clinical trial of allopurinol vs. placebo. XO activit ...
DOI:
10.3390/antiox11071297

95. Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer

Author:
Sven Ljubić; Antonio Sermek; Angela Prgomet Sečan; Marin Prpić; Blanka Jakšić; Jure Murgić; Ana Fröbe; Đurđica Ugarković; Isidoro Feliciello
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
Alphasatellitidae; biomarkers; blood; humans; metastasis; prostatic neoplasms; satellite DNA; satellite RNA
Abstract:
... The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of di ...
DOI:
10.3390/genes13020383

96. Alteration in Gut Microbiota Associated with Zinc Deficiency in School-Age Children

Author:
Xiaohui Chen; Yu Jiang; Zhuo Wang; Youhai Chen; Shihua Tang; Shuyue Wang; Li Su; Xiaodan Huang; Danfeng Long; Liang Wang; Wei Guo; Ying Zhang
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
Acetivibrio; biomarkers; blood serum; cytochrome P-450; cytokines; dietary surveys; food intake; intestinal microorganisms; metabolism; microbial communities; nutrient intake; species diversity; xenobiotics; zinc
Abstract:
... Zinc deficiency could lead to a dynamic variation in gut microbial composition and function in animals. However, how zinc deficiency affects the gut microbiome in school-age children remains unclear. The purpose of this study was to profile the dynamic shifts in the gut microbiome of school-age children with zinc deficiency, and to determine whether such shifts are associated with dietary intake. ...
DOI:
10.3390/nu14142895

97. Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

Author:
Onofrio Valente; Raffaella Messina; Giuseppe Ingravallo; Emilio Bellitti; Domenico Sergio Zimatore; Luigi de Gennaro; Pasqua Abbrescia; Roberta Pati; Claudia Palazzo; Grazia Paola Nicchia; Maria Trojano; Francesco Signorelli; Antonio Frigeri
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 140
ISSN:
1420-682X
Subject:
astrocytes; biomarkers; brain; edema; fluorescein; fluorescent antibody technique; glioblastoma; humans; magnetism; neoplasm progression; patients; protein synthesis
Abstract:
... Glioblastoma multiforme (GBM) is characterized by a remarkable cellular and molecular heterogeneity that make the behavior of this tumor highly variable and resistant to therapy. In addition, the most serious clinical complication of GBM and other brain tumors is the development of vasogenic edema which dramatically increase the intracranial pressure. In the present study we evaluate the expressio ...
DOI:
10.1007/s00018-021-04123-y

98. Alterations in Intestinal Brush Border Membrane Functionality and Bacterial Populations Following Intra-Amniotic Administration (Gallus gallus) of Nicotinamide Riboside and Its Derivatives

Author:
Nikolai Kolba; Amin Zarei; Jacquelyn Cheng; Nikita Agarwal; Younas Dadmohammadi; Leila Khazdooz; Alireza Abbaspourrad; Elad Tako
Source:
Nutrients 2022 v.14 no.15 pp. -
ISSN:
2072-6643
Subject:
Bifidobacterium; Clostridium; Escherichia coli; Gallus gallus; Lactobacillus; NAD (coenzyme); biomarkers; cecum; chlorides; gene expression; interleukin-6; microvilli; nicotinamide; water solubility
Abstract:
... Nicotinamide riboside (NR) acts as a nicotinamide adenine dinucleotide (NAD+) precursor where NR supplementation has previously been shown to be beneficial. Thus, we synthesized and characterized nicotinamide riboside tributyrate chloride (NRTBCl, water-soluble) and nicotinamide riboside trioleate chloride (NRTOCl, oil-soluble) as two new ester derivatives of nicotinamide riboside chloride (NRCl). ...
DOI:
10.3390/nu14153130

99. Alterations in hematological parameters and the structure of peripheral erythrocytes in Nile tilapia (Oreochromis niloticus) exposed to profenofos

Author:
Md Al-Emran; Neaz A. Hasan; Md Polash Khan; S. M. Majharul Islam; Abul Bashar; Ilham Zulfahmi; Md Shahjahan; Kizar Ahmed Sumon
Source:
Environmental science and pollution research 2022 v.29 no.19 pp. 29049-29061
ISSN:
0944-1344
Subject:
Oreochromis niloticus; biomarkers; erythrocytes; fish; glucose; hematocrit; hemoglobin; intensive farming; lethal concentration 50; leukocytes; pollution; profenofos; research
Abstract:
... The burden of pesticide use from agricultural intensification lies in the fact that pesticides may end up in aquatic ecosystems and have pernicious effects on non-target organisms, including fish. Different blood biomarkers, including hemato-biochemical indices, erythrocytic nuclear abnormalities (ENA), and erythrocytic cellular abnormalities (ECA), were observed in Nile tilapia (Oreochromis nilot ...
DOI:
10.1007/s11356-021-17972-8

100. Alterations of RNAs in the insula related to cocaine-induced condition place preference in adolescent mice

Author:
Wenchao Li; Chun Zhang; Yang yang Wang; Lifei Xiao; Yan Feng; Xianhao Huo; Chaofan Wang; Yu Sun; Feng Wang; Tao Sun
Source:
Biochemical and biophysical research communications 2022 v.621 pp. 109-115
ISSN:
0006-291X
Subject:
adolescence; adolescents; biomarkers; brain; catabolism; cocaine; drug resistance; drugs; gene expression regulation; messenger RNA; microRNA; mitogen-activated protein kinase; neurotransmitters; research; synaptic transmission; transcriptome
Abstract:
... Cocaine as a highly addictive psychostimulant can cause changes in the body at the cellular and molecular levels over a long period of time. It reminds us that cocaine may have a potential role in post-transcriptional regulation, but the alteration of insula-expression profile in adolescent cocaine use disorder (CUD) has not been reported. To reveal the mechanisms underlying the post-transcription ...
DOI:
10.1016/j.bbrc.2022.06.080