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- Barsegov, Valeri, et al. Show all 5 Authors
- The Journal of physical chemistry 2012 v.116 no.29 pp. 8545-8555
- biomechanics; cell adhesion; cell division; cylinders; deformation; depolymerization; kinesin; mechanical properties; microtubules; models; physical chemistry; polymers; shrinkage; tubulin
- ... Large-size biomolecular systems that spontaneously assemble, disassemble, and self-repair by controlled inputs play fundamental roles in biology. Microtubules (MTs), which play important roles in cell adhesion and cell division, are a prime example. MTs serve as ″tracks″ for molecular motors, and their biomechanical functions depend on dynamic instabilitya stochastic switching between periods of ...
- Barsegov, Valeri, et al. Show all 8 Authors
- Journal of the American Chemical Society 2014 v.136 no.49 pp. 17036-17045
- biomechanics; chromosome segregation; chromosomes; dissociation; elastic deformation; microtubules; models; physicochemical properties; polymers; thermodynamics; tubulin
- ... Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits. However, the thermodynamics of these bonds and the microtubule physicochemical properties are poorly understood. Here, we explore the biomechanics of microtubule polymers using multiscale computational modeling and nanoindentations ...
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