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- Müller-Peddinghaus, R., et al. Show all 6 Authors
- Beagle; animal pathology; atrophy; basement membrane; biopsy; body weight; clinical examination; complications (disease); digestion; dogs; epithelial cells; excretion; filtrates; glomerulonephritis; hydrogen; laboratory animals; organelles; pathogenesis; phosphates; polyacrylamide gel electrophoresis; potassium; proteinuria; sclerosis; shrinkage; urine
- ... A disseminated atrophy of the proximal tubule accompanies K₂HPO₄-induced nephropathy in dogs. These pathologic processes cause glomerular changes that pass through different inflammatory stages and terminate in glomerular sclerosis. Experimental animals, design of the experiment and methods have been described . During the 14-week study we determined the amount of urine (24 hours), protein (mg ...
- Müller-Peddinghaus, R., et al. Show all 7 Authors
- Beagle; acid phosphatase; animal pathology; atrophy; basement membrane; beta-glucuronidase; biopsy; blood; body weight; creatinine; detritus; dipotassium hydrogen phosphate; dogs; electron microscopy; epithelial cells; extrusion; fibroblasts; histochemistry; hydrogen; lysosomes; necropsy; nephrocalcinosis; oral administration; pathogenesis; potassium; proteinuria; proximal tubules; sediments; urea nitrogen; vacuoles
- ... A nephropathy with severe tubular atrophy was observed in Beagle dogs after oral administration of K₂HPO₄ for 14 or 38 weeks. We describe the complete lysosomal degradation of atrophying tubular epithelial cells. During two experiments of 14 and 38 weeks duration, respectively, a total of 15 Beagle dogs received 0.8 g K₂HPO₄/kg body weight daily with their food. All dogs were examined clinically a ...