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You searched for: Author jiahao Remove constraint Author: jiahao Subject biopsy Remove constraint Subject: biopsy
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1. Assessment of the Risk of Blastomere Biopsy during Preimplantation Genetic Diagnosis in a Mouse Model: Reducing Female Ovary Function with an Increase in Age by Proteomics Method

Author:
Sha, Jiahao,   et al.   ; Yu, Yang; Zhao, Yue; Li, Rong; Li, Li; Zhao, Hongcui; Li, Min; Zhou, Qi; Qiao, Jie;     Show all 9 Authors
Source:
Journal of Proteome Research 2013 v.12 no.12 pp. 5475-5486
ISSN:
1535-3907
Subject:
Western blotting; animal models; animal ovaries; biopsy; blood serum; chromosomes; congenital abnormalities; female fertility; females; mice; mutation; protein synthesis; proteins; proteome; proteomics; puberty; reverse transcriptase polymerase chain reaction; risk; screening
Abstract:
... Preimplantation genetic diagnosis (PGD) is important for screening genetic and chromosome mutations in embryos so that the efficiency of assisted reproductive treatment can be increased and birth defects can be decreased; however, some studies have reported a risk from this technology as well as other assisted reproductive technologies. We have developed a blastomere biopsy mouse model to assess t ...
DOI:
10.1021/pr400366j

2. Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice

Author:
Sha, Jiahao,   et al.   ; Wu, Yibo; Lv, Zhuo; Yang, Yang; Dong, Guoying; Yu, Yang; Cui, Yiqiang; Tong, Man; Wang, Liu; Zhou, Zuomin; Zhu, Hui; Zhou, Qi;     Show all 12 Authors
Source:
Cellular and molecular life sciences 2014 v.71 no.9 pp. 1761-1774
ISSN:
1420-682X
Subject:
DNA; DNA methylation; adults; biopsy; brain; embryogenesis; epigenetics; genes; loci; memory; messenger RNA; mice; neurodevelopment; neurons; progeny; promoter regions; proteins; risk
Abstract:
... Blastomere biopsy is used in preimplantation genetic diagnosis; however, the long-term implications on the offspring are poorly characterized. We previously reported a high risk of memory defects in adult biopsied mice. Here, we assessed nervous function of aged biopsied mice and further investigated the mechanism of neural impairment after biopsy. We found that aged biopsied mice had poorer spati ...
DOI:
10.1007/s00018-013-1466-2