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You searched for: Subject term biosynthesis Remove constraint Subject term: biosynthesis Subject term chelation Remove constraint Subject term: chelation
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1. A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs

Author:
Jeongmi Kim; Yong-Joon Cho; Eunsoo Do; Jaehyuk Choi; Guanggan Hu; Brigitte Cadieux; Jongsik Chun; Younghoon Lee; James W. Kronstad; Won Hee Jung
Source:
Fungal genetics and biology 2012 v.49 no.11 pp. 955-966
ISSN:
1087-1845
Subject:
Cryptococcus neoformans; NAD (coenzyme); chelation; ergosterol; ferroxidase; fluconazole; gene expression regulation; genes; growth retardation; homeostasis; mutants; pathogenesis; phenotype; transcriptome; transcriptomics
Abstract:
... The high-affinity reductive iron uptake system that includes a ferroxidase (Cfo1) and an iron permease (Cft1) is critical for the pathogenesis of Cryptococcus neoformans. In addition, a mutant lacking CFO1 or CFT1 not only has reduced iron uptake but also displays a markedly increased susceptibility to azole antifungal drugs. Altered antifungal susceptibility of the mutants was of particular inter ...
DOI:
10.1016/j.fgb.2012.08.006
PubMed:
22975303
PubMed Central:
PMC4706552

2. A unique aluminum resistance mechanism conferred by aluminum and salicylic-acid-activated root efflux of benzoxazinoids in maize

Author:
Zunkang Zhao; Xiaofeng Gao; Ye Ke; Minmin Chang; Lu Xie; Xiaofeng Li; Minghua Gu; Jiping Liu; Xinlian Tang
Source:
Plant and soil 2019 v.437 no.1-2 pp. 273-289
ISSN:
0032-079X
Subject:
aluminum; benzoxazinoids; biosynthesis; chelation; corn; cultivars; exudation; hydroxamic acids; root growth; root tips; salicylic acid
Abstract:
... BACKGROUND AND AIMS: Although aluminum (Al) exclusion via root exudation of organic matters is a common resistance mechanism adopted by many plant species, whether root exudation of benzoxazinoids, such as hydroxamic acids (HAs), confers Al resistance remains unclear. METHODS: We performed physiological characterization for an Al-resistant maize cultivar TY and a sensitive maize cultivar ZD. RESUL ...
DOI:
10.1007/s11104-019-03971-9

3. Advances in the antimicrobial and therapeutic potential of siderophores

Author:
Marta Ribeiro; Manuel Simões
Source:
Environmental chemistry letters 2019 v.17 no.4 pp. 1485-1494
ISSN:
1610-3653
Subject:
antibiotics; bacterial growth; biosynthesis; chelation; drug therapy; environmental science; iron; siderophores; starvation; virulence
Abstract:
... The increasing bacterial resistance from antibiotic overuse has fostered the search for novel antimicrobial strategies. In particular, bacterial systems involving iron (Fe) uptake are studied to develop new therapeutics against infectious diseases, because iron is crucial for bacterial growth and is a main virulence factor for infection. Iron assimilation is commonly based on the production of sid ...
DOI:
10.1007/s10311-019-00887-9

4. Ambiguity of NRPS Structure Predictions: Four Bidentate Chelating Groups in the Siderophore Pacifibactin

Author:
Clifford D. Hardy; Alison Butler
Source:
Journal of natural products 2019 v.82 no.4 pp. 990-997
ISSN:
1520-6025
Subject:
Alcanivorax; bioinformatics; biosynthesis; chelation; enzymes; gallium; genome mining; iron; ligands; multigene family; nuclear magnetic resonance spectroscopy; peptides; photochemical reactions; prediction; siderophores; titration
Abstract:
... Identified through a bioinformatics approach, a nonribosomal peptide synthetase gene cluster in Alcanivorax pacificus encodes the biosynthesis of the new siderophore pacifibactin. The structure of pacifibactin differs markedly from the bioinformatic prediction and contains four bidentate metal chelation sites, atypical for siderophores. Genome mining and structural characterization of pacifibactin ...
DOI:
10.1021/acs.jnatprod.8b01073

5. Antioxidant and melanogenesis-inhibitory activities of collagen peptide from jellyfish (Rhopilema esculentum)

Author:
Zhuang, Yongliang; Sun, Liping; Zhao, Xue; Wang, Jingfeng; Hou, Hu; Li, Bafang
Source:
Journal of the science of food and agriculture 2009 v.89 no.10 pp. 1722-1727
ISSN:
0022-5142
Subject:
reaction inhibition; biosynthesis; cosmetics; copper; melanoma; proteinases; proteolysis; seafoods; collagen; peptides; free radical scavengers; Scyphozoa; enzymatic hydrolysis; melanin; cell lines; antioxidant activity; chelation
Abstract:
... BACKGROUND: Jellyfish collagen was hydrolysed with trypsin and properase E, and jellyfish collagen peptide (JCP) was purified from the enzymatic hydrolysate using ion exchange chromatography and gel filtration. The antioxidant activity of JCP in a linoleic acid emulsion system, its superoxide anion- and hydroxyl radical-scavenging activities and its copper-chelating ability were evaluated in vitro ...
DOI:
10.1002/jsfa.3645

6. Boron alleviates cadmium toxicity in Brassica napus by promoting the chelation of cadmium onto the root cell wall components

Author:
Xiuwen Wu; Haixing Song; Chunyun Guan; Zhenhua Zhang
Source:
Science of the total environment 2020 v.728 pp. 138833
ISSN:
0048-9697
Subject:
Brassica napus; Fourier transform infrared spectroscopy; atomic absorption spectrometry; biosynthesis; boron; cadmium; cell viability; cell walls; cellulose; chelation; demethylation; environment; fluorescent dyes; hemicellulose; metabolomics; organelles; pectins; plant root cells; polygalacturonase; rapeseed; reactive oxygen species; rice oil; toxicity; transcriptomics; xyloglucan:xyloglucosyl transferase; China
Abstract:
... In Southern China, rice-oil rotations occur on soils with high levels of cadmium (Cd) and low levels of available boron (B). Boron can alleviate Cd toxicity, as it affects the plant cell wall structures and the components that block the entry of Cd into the cytoplasm; however, these mechanisms are not well understood. Fourier transform infrared spectroscopy (FTIR), fluorescent probe dye, electron ...
DOI:
10.1016/j.scitotenv.2020.138833

7. Built to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors

Author:
Leonard Kaysser
Source:
Natural product reports 2019 v.36 no.12 pp. 1654-1686
ISSN:
1460-4752
Subject:
Lewis acids; Lewis bases; active sites; biosynthesis; chelation; diabetes; genome; hypertension; medicine; metalloproteinases; peptides; thrombosis
Abstract:
... Covering: up to 2019 Inhibitors of proteases and related enzymes have versatile applications in medicine and other areas. They are used in the clinic e.g. for the treatment of cancer, hypertension, thrombosis, diabetes as well as viral and bacterial infections. Most of these drugs are produced synthetically but a substantial part of them has been developed from or are inspired by natural products. ...
DOI:
10.1039/c8np00095f

8. Calcium deprivation disrupts enlargement of Chara corallina cells: further evidence for the calcium pectate cycle

Author:
Timothy E. Proseus; John S. Boyer
Source:
Journal of experimental botany 2012 v.63 no.10 pp. 3953-3958
ISSN:
0022-0957
Subject:
crosslinking; turgor; biosynthesis; chelating agents; cell walls; Chara corallina; calcium; pectins; Chlorophyta; plasma membrane; culture media; prediction; ethylene glycol tetraacetic acid
Abstract:
... Pectin is a normal constituent of cell walls of green plants. When supplied externally to live cells or walls isolated from the large-celled green alga Chara corallina, pectin removes calcium from load-bearing cross-links in the wall, loosening the structure and allowing it to deform more rapidly under the action of turgor pressure. New Ca2+ enters the vacated positions in the wall and the externa ...
DOI:
10.1093/jxb/ers089
PubMed:
22442410
PubMed Central:
PMC3388837

9. Chlorella vulgaris up-modulation of myelossupression induced by lead: The role of stromal cells

Author:
Queiroz, Mary L.S.; Torello, Christiane O.; Perhs, Simone M.C.; Rocha, Michelle C.; Bechara, Etelvino J.H.; Morgano, Marcelo A.; Valadares, Marize C.; Rodrigues, Ana Paula O.; Ramos, Aline Lisie; Soares, Chrislaine O.
Source:
Food and chemical toxicology 2008 v.46 no.9 pp. 3147-3154
ISSN:
0278-6915
Subject:
Chlorella vulgaris; Chlorophyceae; chelation; bone marrow cells; medicinal properties; phytochelatins; antinutritional factors; metabolic detoxification; interleukin-6; lead poisoning; lead; hematopoietic cell growth factors
DOI:
10.1016/j.fct.2008.07.005
PubMed:
18684395

10. Citrate Stimulates Oligosaccharide Synthesis in Metabolically Engineered Agrobacterium sp.

Author:
Anne M. Ruffing; Rachel Ruizhen Chen
Source:
Applied biochemistry and biotechnology 2011 v.164 no.6 pp. 851-866
ISSN:
0273-2289
Subject:
Agrobacterium; Escherichia coli; buffers; carbon; chelation; citrates; energy; hosts; metabolism; metal ions; pH; solubility; sucrose
Abstract:
... Agrobacterium sp. ATCC 31749 was previously shown to be an advantageous host for oligosaccharide production. Unexpectedly, the addition of citrate to the oligosaccharide synthesis reaction resulted in up to a sixfold improvement in the production N-aceytl-lactosamine, a disaccharide. The possible mechanisms for this citrate-induced stimulation of oligosaccharide production were investigated, inclu ...
DOI:
10.1007/s12010-011-9179-1
PubMed:
21302148

11. Citric acid-mediated abiotic stress tolerance in plants

Author:
Tahjib-Ul-Arif Md; Zahan Mst Ishrat; Karim Md Masudul; Imran Shahin; Iii Charles T.; Islam Md Saiful; Mia Md Ashik; Hannan Md Abdul; Rhaman Mohammad Saidur; Hossain Md Afzal; Brestic Marian; Skalicky Milan; Murata Yoshiyuki
Source:
International journal of molecular sciences 2021 v.22 no.13 pp. 7235
ISSN:
1422-0067
Subject:
abiotic stress; antioxidant activity; biosynthesis; chelation; chlorophyll; citrates; citric acid; heavy metals; osmoregulation; plant growth; plant hormones; reactive oxygen species; secondary metabolites; stress tolerance
Abstract:
... Several recent studies have shown that citric acid/citrate (CA) can confer abiotic stress tolerance to plants. Exogenous CA application leads to improved growth and yield in crop plants under various abiotic stress conditions. Improved physiological outcomes are associated with higher photo-synthetic rates, reduced reactive oxygen species, and better osmoregulation. Application of CA also induces ...
Handle:
10113/7481989
DOI:
10.3390/ijms22137235

12. Combined treatment of Pseudomonas aeruginosa biofilm with lactoferrin and xylitol inhibits the ability of bacteria to respond to damage resulting from lactoferrin iron chelation

Author:
Mary Cloud B. Ammons; Loren S. Ward; Scot Dowd; Garth A. James
Source:
International journal of antimicrobial agents 2011 v.37 no.4 pp. 316-323
ISSN:
0924-8579
Subject:
Pseudomonas aeruginosa; anti-infective agents; anti-infective properties; bacteria; biofilm; biosynthesis; cell membranes; chelation; gene expression; gene expression regulation; lactoferrin; microarray technology; models; operon; pathogens; pressure ulcers; siderophores; xylitol
Abstract:
... With an ageing and ever more obese population, chronic wounds such as diabetic ulcers, pressure ulcers and venous leg ulcers are an increasingly relevant medical concern. Identification of bacterial biofilm contamination as a major contributor to non-healing wounds demands biofilm-targeted strategies to manage chronic wounds. Pseudomonas aeruginosa has been identified as a principal biofilm-formin ...
DOI:
10.1016/j.ijantimicag.2010.12.019
PubMed:
21377840
PubMed Central:
PMC7008007

13. Comparative transcriptome analysis of the hyperaccumulator plant Phytolacca americana in response to cadmium stress

Author:
Le Zhao; Yun-Hao Zhu; Min Wang; Li-Gang Ma; Yong-Guang Han; Meng-Jia Zhang; Xing-Can Li; Wei-Sheng Feng; Xiao-Ke Zheng
Source:
3 Biotech 2021 v.11 no.7 pp. 327
ISSN:
2190-572X
Subject:
Phytolacca americana; biosynthesis; cadmium; cell walls; chelation; databases; flavonoids; gene expression regulation; glutathione; heavy metals; hyperaccumulators; lignin; photosynthesis; sulfur; thiols; transcriptome; transcriptomics; unigenes; vacuoles
Abstract:
... To study the molecular mechanism of the hyperaccumulator plant Phytolacca americana against cadmium (Cd) stress, the leaves of P. americana treated with 400 μM Cd for 0, 2, 12, and 24 h were harvested for comparative transcriptome analysis. In total, 110.07 Gb of clean data were obtained, and 63,957 unigenes were acquired after being assembled. Due to the lack of P. americana genome information, o ...
DOI:
10.1007/s13205-021-02865-x

14. Comparative transcriptome combined with biochemical and physiological analyses provide new insights toward cadmium accumulation with two contrasting Nicotiana species

Author:
Yan Zhang; Jiangtao Chao; Xiuchun Li; Chong Zhang; Rayyan Khan; Shasha Du; Na Xu; Lin Song; Haiwei Liu; Yi Shi
Source:
Physiologia plantarum 2021 v.173 no.1 pp. 369-383
ISSN:
0031-9317
Subject:
Nicotiana rustica; Nicotiana tabacum; biosynthesis; cadmium; cell walls; chelation; cytoplasm; enzyme activity; fauna; flora; gene expression regulation; glutathione transferase; oxidation; phenylalanine; soil; superoxide dismutase; toxicity; transcriptome; transcriptomics
Abstract:
... Cadmium (Cd) is known as one of the most hazardous elements in the environment and a persistent soil constraint toxic to all flora and fauna. In this study, we conducted physiological, biochemical, and transcriptomic analyses of Nicotiana rustica (N. rustica) and Nicotiana tabacum (N. tabacum) treated with CdCl₂ to know the underlying molecular mechanisms of Cd accumulation. As a result, N. rustic ...
DOI:
10.1111/ppl.13431

15. Comprehensive analysis of phenotype, microstructure and global transcriptional profiling to unravel the effect of excess copper on the symbiosis between nitrogen-fixing bacteria and Medicago lupulina

Author:
Minxia Chou; Yali Sun; Jieyu Yang; Yujie Wang; Yajuan Li; Guijie Yuan; Dehui Zhang; Jiamei Wang; Gehong Wei
Source:
Science of the total environment 2019 v.656 pp. 1346-1357
ISSN:
0048-9697
Subject:
Medicago lupulina; antimicrobial properties; antioxidant activity; biosynthesis; cell walls; chelation; copper; ecological restoration; ethylene; gene expression; gene expression regulation; genes; heavy metals; legumes; metal tolerance; microstructure; nitrogen-fixing bacteria; nodulation; peptides; phenotype; sequence analysis; symbiosis; transcription (genetics); ultrastructure
Abstract:
... Legume-rhizobial symbiosis plays an important role in agriculture and ecological restoration. However, knowledge of the molecular mechanisms, especially the microstructure and global transcriptional profiling, of the symbiosis process under heavy metal contamination is limited. In this study, a heavy metal-tolerant legume, Medicago lupulina, was treated with different concentrations of copper (Cu) ...
DOI:
10.1016/j.scitotenv.2018.12.005

16. Deciphering the iron response in Acinetobacter baumannii: A proteomics approach

Author:
Chika C. Nwugo; Jennifer A. Gaddy; Daniel L. Zimbler; Luis A. Actis
Source:
Journal of proteomics 2011 v.74 no.1 pp. 44-58
ISSN:
1874-3919
Subject:
Acinetobacter baumannii; RNA; bacteria; biosynthesis; chelation; correlation; cultured cells; energy; gels; gene expression regulation; mass spectrometry; protein synthesis; proteomics; receptors; siderophores
Abstract:
... Iron is an essential nutrient that plays a role in bacterial differential gene expression and protein production. Accordingly, the comparative analysis of total lysate and outer membrane fractions isolated from A. baumannii ATCC 19606ᵀ cells cultured under iron-rich and -chelated conditions using 2-D gel electrophoresis-mass spectrometry resulted in the identification of 58 protein spots different ...
DOI:
10.1016/j.jprot.2010.07.010
PubMed:
20692388
PubMed Central:
PMC2997898

17. Decreased and increased expression of the subunit CHL I diminishes Mg chelatase activity and reduces chlorophyll synthesis in transgenic tobacco plants

Author:
Papenbrock, J.; Pfundel, E.; Mock, H.P.; Grimm, B.
Source:
plant journal 2000 v.22 no.2 pp. 155-164
ISSN:
0960-7412
Subject:
biosynthesis; complementary DNA; antisense DNA; transgenic plants; iron; magnesium; gene expression; biochemical pathways; photosystem II; Nicotiana tabacum; photosystem I; chlorophyll; promoter regions; chelation
Abstract:
... The chelation of Fe2 and Mg2+ ions forms protoheme IX and Mg-protoporphyrin IX, respectively, and the latter is an intermediate in chlorophyll synthesis. Active magnesium protoporphyrin IX chelatase (Mg-chelatase) is an enzyme complex consisting of three different subunits. To investigate the function of the CHL I subunit of Mg-chelatase and the effects of modified Mg-chelatase activity on the tet ...
DOI:
10.1046/j.1365-313x.2000.00724.x
PubMed:
10792831

18. Dissection of Porphyrin-Induced Conformational Dynamics in the Heme Biosynthesis Enzyme Ferrochelatase

Author:
Asuru Awuri P.; An Mier; Busenlehner Laura S.
Source:
Biochemistry 2012 v.51 no.36 pp. 7116-7127
ISSN:
1520-4995
Subject:
active sites; biosynthesis; chelation; deuterium; heme; humans; iron; mass spectrometry; protoporphyrin; solvents
Abstract:
... Human ferrochelatase (EC 4.99.1.1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis, an essential process to most organisms given the vast intracellular functions of heme. Even with multiple ferrochelatase structures available, the exact mechanism for iron insertion into porphyrin is still a matter for debate. It is clear, however, that conformation ...
DOI:
10.1021/bi300704c

19. Diurnal Changes in Transcript and Metabolite Levels during the Iron Deficiency Response of Rice

Author:
Jamie Selby-Pham; Adrian Lutz; Laura T. Moreno-Moyano; Berin A. Boughton; Ute Roessner; Alexander A. T. Johnson
Source:
Rice 2017 v.10 no.1 pp. 14
ISSN:
1939-8425
Subject:
Hordeum vulgare; Oryza sativa; amines; barley; biosynthesis; chelation; diurnal variation; gene expression; genes; iron; mass spectrometry; metabolites; nutrient deficiencies; oxidative stress; phytosiderophores; remediation; rhizosphere; rice; roots; secretion; stress response; wheat
Abstract:
... BACKGROUND: Rice (Oryza sativa L.) is highly susceptible to iron (Fe) deficiency due to low secretion levels of the mugineic acid (MA) family phytosiderophore (PS) 2′-deoxymugineic acid (DMA) into the rhizosphere. The low levels of DMA secreted by rice have proved challenging to measure and, therefore, the pattern of DMA secretion under Fe deficiency has been less extensively studied relative to o ...
DOI:
10.1186/s12284-017-0152-7
PubMed:
28429296
PubMed Central:
PMC5398970

20. Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization

Author:
Romão, Célia V.; Ladakis, Dimitrios; Lobo, Susana A.L.; Carrondo, Maria A.; Brindley, Amanda A.; Deery, Evelyne; Matias, Pedro M.; Pickersgill, Richard W.; Saraiva, Lígia M.; Warren, Martin J.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.1 pp. 97-102
ISSN:
0027-8424
Subject:
Archaeoglobus; Desulfovibrio vulgaris; Salmonella enterica; active sites; biosynthesis; chelation; cobalt; crystal structure; enzymes; evolution; heme; iron; oligomerization; protein subunits; protoporphyrin; vitamin B12
Abstract:
... The class II chelatases associated with heme, siroheme, and cobalamin biosynthesis are structurally related enzymes that insert a specific metal ion (Fe²⁺ or Co²⁺) into the center of a modified tetrapyrrole (protoporphyrin or sirohydrochlorin). The structures of two related class II enzymes, CbiXS from Archaeoglobus fulgidus and CbiK from Salmonella enterica, that are responsible for the insertion ...
DOI:
10.1073/pnas.1014298108
PubMed:
21173279
PubMed Central:
PMC3017170