Author: rossler / Subject: biosynthesis

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Author:: Rössler, Oliver G., et al. ; Thiel, Gerald; Müller, Isabelle; Show all 3 Authors
Source:: Molecular and Cellular Endocrinology 2014 v.388 pp. 10-19
ISSN:: 0303-7207
Subject:: biosynthesis; glucose; homeostasis; insulin; insulin receptors; insulin resistance; islets of Langerhans; pregnenolone; sulfates; tissues; transcription (genetics); transcription factors; zinc finger motif
Abstract:: ... Egr-1 and the related zinc finger transcription factors Egr-2, Egr-3, and Egr-4 are stimulated by many extracellular signaling molecules and represent a convergence point for intracellular signaling cascades. Egr-1 expression is induced in insulinoma cells and pancreatic β-cells following stimulation with either glucose, or pregnenolone sulfate. Moreover, stimulation of Gαq and Gαs-coupled recepto ...
DOI:: 10.1016/j.mce.2014.03.001
: http://dx.doi.org/10.1016/j.mce.2014.03.001

Author:: Rössler, Oliver G., et al. ; Langfermann, Daniel S.; Thiel, Gerald; Show all 3 Authors
Source:: Molecular and cellular endocrinology 2018 v.472 pp. 126-139
ISSN:: 0303-7207
Subject:: biosynthesis; blood serum; calcium channels; cyclins; genes; glucose; islets of Langerhans; mitogen-activated protein kinase; mutational analysis; signal transduction; transcription (genetics); transcription factors; transcriptional activation
Abstract:: ... Stimulation of pancreatic β-cells with glucose activates the protein kinases B-Raf and extracellular signal-regulated protein kinase that participate in glucose sensing. Inhibition of both kinases results in impairment of glucose-regulated gene transcription. To analyze the signaling pathway controlled by B-Raf, we expressed a conditionally active form of B-Raf in INS-1 insulinoma cells. Here, we ...
DOI:: 10.1016/j.mce.2017.12.003
: http://dx.doi.org/10.1016/j.mce.2017.12.003