Jump to Main Content
- Mancino, Marilena, et al. Show all 11 Authors
- Developmental biology 2019 v.455 no.1 pp. 100-111
- Drosophila melanogaster; biochemical pathways; biogenesis; biosynthesis; cell proliferation; ecdysone; genes; mammals; models; phenotype; programmed cell death; protein synthesis; ribosomes; signal transduction; transcription factors; yeasts
- ... During development, ribosome biogenesis and translation reach peak activities, due to impetuous cell proliferation. Current models predict that protein synthesis elevation is controlled by transcription factors and signalling pathways. Developmental models addressing translation factors overexpression effects are lacking. Eukaryotic Initiation Factor 6 (eIF6) is necessary for ribosome biogenesis a ...