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- Tsuda, Yoshimi, et al. Show all 6 Authors
- Virology journal 2017 v.14 no.1 pp. 13
- genome; blood; body weight changes; adults; clones; amino acids; viruses; patients; pathogenesis; glycoproteins; females; sequence analysis; fur; serotypes; mice; pathogenicity; neutralizing antibodies; kidneys; Hantaan orthohantavirus; inoculum; intravenous injection; hemorrhage; viral proteins; animal models; RNA; fever
- ... BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus infection is characterized by fever, renal dysfunction and hemorrhage. An animal model mimicking symptoms of HFRS remains to be established. In this study, we evaluated the pathogenicity of an HFRS patient-derived Hantaan virus (HTNV) in adult mice. METHODS: Five clones of HTNV strain KHF 83-61 BL (KHFV) that was derived ...
- PubMed Central: