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- Malhotra, Rajiv Kumar, et al. Show all 11 Authors
- Phytomedicine 2019 v.56 pp. 147-155
- DNA fragmentation; adverse effects; apoptosis; apples; blood pressure; blood sampling; blood serum; cannulas; cardioprotective effect; carotid arteries; caspase-3; cytochrome c; heart; histology; inflammation; laboratory animals; myocardial ischemia; oxidants; oxidative stress; pro-apoptotic proteins; rats; strawberries; therapeutics; transcription factor NF-kappa B
- ... The therapeutic options for the reducing the damage caused by myocardial ischemia are limited and not devoid of adverse effects. The role of the flavanoid, fisetin, predominantly found in strawberry and apple, is yet to be explored in the heart.Male Wistar rats (n = 48) were administered fisetin (10, 20 & 40 mg/kg/day, orally) or vehicle for 28 days while ISO, 85 mg/kg, subcutaneously, was also ad ...
- Malhotra, Rajiv Kumar, et al. Show all 7 Authors
- Phytomedicine 2016 v.23 no.12 pp. 1401-1408
- antioxidant activity; antioxidants; apoptosis; blood sampling; blood serum; cannulas; catalase; coronary vessels; creatine; diet; glutathione; hemodynamics; histopathology; immunohistochemistry; inflammation; interleukin-6; kaempferol; lactate dehydrogenase; lipid peroxidation; malondialdehyde; models; morbidity; mortality; myocardial infarction; myocardium; oxidative stress; protective effect; rats; risk; superoxide dismutase; toxicity; tumor necrosis factor-alpha
- ... Myocardial infarction (MI) continues to be associated with high morbidity and mortality worldwide despite the availability of current therapeutic modalities. Kaempferol (KMP), a dietary flavonoid, possesses good antioxidant, immunomodulatory and anti-apoptotic properties and has been evaluated in the present study for its role in mitigating myocardial injury following MI.In this study, the ability ...