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You searched for: Author "Liu, Luming" Remove constraint Author: "Liu, Luming" Subject blood serum Remove constraint Subject: blood serum
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1. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity

Author:
Liu, Luming,   et al.   ; Li, Pei; Zhou, Guoyu; Tian, Zhiyuan; Luo, Chen; Xia, Tao; Chen, Jingwen; Niu, Qiang; Dong, Lixin; Zhao, Qian; Wang, Aiguo; Zhang, Shun;     Show all 12 Authors
Source:
The Science of the total environment 2018 v.645 pp. 363-371
ISSN:
0048-9697
Subject:
DNA fragmentation; apoptosis; autophagy; blood serum; brain; caspase-12; caspase-3; endoplasmic reticulum; epithelial cells; females; fetus; flame retardants; gene expression regulation; infants; laboratory animals; mechanism of action; neurotoxicity; progeny; rats; triiodothyronine; unfolded protein response; weaning
Abstract:
... Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuses and infants. However, little is known about the effects of PBDE-47 on maternal thyroid status and its mode of action. Here, using female Sprague-Dawley ra ...
DOI:
10.1016/j.scitotenv.2018.07.138

2. Perigestational low-dose BDE-47 exposure alters maternal serum metabolome and results in sex-specific weight gain in adult offspring

Author:
Liu, Luming,   et al.   ; Gao, Hui; Li, Pei; Yang, Kaichao; Xiao, Boya; Zhou, Guoyu; Tian, Zhiyuan; Luo, Chen; Xia, Tao; Dong, Lixin; Zhao, Qian; Wang, Aiguo; Zhang, Shun;     Show all 13 Authors
Source:
Chemosphere 2019 v.233 pp. 174-182
ISSN:
0045-6535
Subject:
adiposity; adulthood; adults; amino acids; biochemical pathways; blood serum; carbohydrates; children; conception; females; gas chromatography-mass spectrometry; lipids; males; malnutrition; metabolites; metabolome; metabolomics; obesity; polybrominated diphenyl ethers; pups; rats
Abstract:
... Emerging evidence suggests environmental contaminant exposures during critical windows of development may contribute to the increasing prevalence of obesity. It has been shown that early life polybrominated diphenyl ethers exposures have critical impacts on child weight trajectories, however, little is known about their maternal mechanisms responsible for offspring obesity development. In this stu ...
DOI:
10.1016/j.chemosphere.2019.05.277