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- Okuno, M., et al. Show all 6 Authors
- Nutrition and cancer 1996 v.26 no.2 pp. 203-208
- carcinogenesis; metabolism; messenger RNA; canthaxanthin; liver; blood serum; body weight; proto-oncogenes; mice; beta-carotene; antineoplastic agents; gene expression; growth retardation; retinoic acid; carcinogens; papilloma; dietary supplements
- ... Using mouse skin papilloma as a model system, we examined whether the antitumorigenic activity of carotenoids was related to their provitamin A activity. Oral administration of canthaxanthin (CX) or beta-carotene at 200 mg/kg/day for 14 days significantly reduced the cumulative size of papillomas induced on the skin by 9,10-dimethyl-1,2-benzanthracene (p < 0.05), after the accumulation of these ca ...
- Okuno, M., et al. Show all 9 Authors
- Nutrition and cancer 1998 v.30 no.3 pp. 186-193
- fatty acids; dietary fat; animal proteins; safflower oil; tallow; carcinogenesis; nitrosamines; glutathione transferase; gene expression; adenoma; incidence; phospholipids; weight; messenger RNA; Perilla; body weight; olive oil; rats; food intake; liver; experimental diets; carcinoma; beef; animal models
- ... We have investigated the modulating effects of low amounts of dietary oils rich in polyunsaturated fatty acids (PUFA) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male F344 rats. A total of 112 animals were divided into eight groups. Groups 1-4 were given drinking water containing 40 ppm DEN for five weeks. Groups 5-8 served as controls without DEN treatment. Groups 1 and 5 were fed ...