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... Osteoporosis is a kind of global chronic bone disease characterized by progressive loss of bone mass and bone quality reduction, leading to a largely increased risk of bone fragility. In clinics, the current treatment of osteoporosis relies on the inhibition of bone damage by osteoclasts but ignores the function of immune cells in the progress of osteoporosis, leading to much compromised therapeut ...
National Health and Nutrition Examination Survey; bone density; bone health; bone resorption; carbohydrate intake; carbohydrates; clinical nutrition; cross-sectional studies; diet recall; energy intake; high protein diet; metabolism; nutrient density; risk
Abstract:
... Although it is well known dietary factors are closely correlated with bone health, the association between macronutrients intake distribution and bone mineral density (BMD) is still unclear. The aims of this study were to investigate how macronutrients distribution was correlated with BMD, and to evaluate how the substitution between macronutrients could be associated with BMD. We conducted a cros ...
biocompatible materials; bone density; bone mineralization; boron; hyaluronic acid; metabolic diseases; mineralization; morbidity; mortality; osteoporosis; ovariectomy; rabbits; research
Abstract:
... Osteoporosis is a systemic metabolic disease defined by a decreased bone mineral density, microarchitectural deterioration, and an increased incidence of fragility fractures that may lead to morbidity and mortality. Boron may stimulate new bone formation and regeneration, when combined with nano-hydroxyapatite. We questioned whether injecting boron-containing nano-hydroxyapatite composites with hy ...
bone density; bone formation; bone strength; endocrinology; micro-computed tomography; models; osteoblasts; osteoclasts; osteoporosis; ovariectomy; postmenopause; proteasome endopeptidase complex; proteasome inhibitors; protein content; recombinant proteins
Abstract:
... Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in OP, an ...
biomarkers; blood lipids; blood serum; body weight; bone density; bone resorption; dual-energy X-ray absorptiometry; exercise; femur; lactation; low density lipoprotein cholesterol; questionnaires; sports; urine
Abstract:
... This study evaluated the changes in bone mineral density (BMD) and serum lipids across the first postpartum year in lactating women compared to never-pregnant controls, and the influence of physical activity (PA). The study also explored whether N-telopeptides, pyridinoline, and deoxypyridinoline in urine serve as biomarkers of bone resorption. A cohort of 18 initially lactating postpartum women a ...
alizarin; alkaline phosphatase; bone density; bone formation; circular RNA; humans; luciferase; osteoblasts; osteoporosis; reporter genes
Abstract:
... Human adipose mesenchymal stem cells (hAMSCs) can differentiate into osteoblasts, which can enhance bone mass and bone formation. Circular RNA plays an important role in the osteoblast differentiation of mesenchymal stem cells, but the mechanism remains unclear. We used hAMSCs to study the role of circRNA hsa_circ_0001421/miR-608/SP7 axis in osteoblast differentiation. qRT-PCR, western blotting, a ...
adipose tissue; adiposity; bone density; bone health; bone metabolism; femur; lumbar spine; obesity; premenopause; regression analysis; underweight
Abstract:
... Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. We evaluated the circulating SIRT1 and sclerostin relationship with mass and quality of bone while considering the degree of adiposity. Sixty-six premenopausal women (16 underweight, 25 normal weight and 25 with obesity), aged <50 years, were enrolled. Plasma SIRT1, sclerostin and DXA body composition (tota ...
aluminum; bone density; cortex; horses; metacarpus; radiography; regression analysis; veterinary medicine
Abstract:
... Digital radiographs are common for estimating bone mineral content (BMC) in horses with radiographic bone aluminum equivalents (RBAE). Processing algorithms are used to produce clearer images of digital radiographs in clinical settings, but this distorts RBAE. This study compared RBAE from digital radiographs to BMC from bone ash, and physical and digital morphology measurements. Digital radiograp ...
Beata Nowak; Agnieszka Matuszewska; Adam Szeląg; Maciej Danielewski; Wojciech Dziewiszek; Anna Nikodem; Jarosław Filipiak; Diana Jędrzejuk; Marek Bolanowski; Alicja Z. Kucharska; Narcyz Piórecki; Tomasz Piasecki; Tomasz Sozański
Cornus mas; adiponectin; blood serum; bone density; bone resorption; calcium; modulus of rupture; nicotinamide phosphoribosyltransferase; obesity; ovariectomy; oxidative stress; resistin; tibia; visceral fat; weight gain
Abstract:
... The aim of the current study was to to investigate the influence of cornelian cherry (Cornus mas L.; CM) extract on ovariectomy-induced metabolic changes including bone loss, obesity development, adipokines imbalance and oxidative stress. Intragastrical administration of CM ameliorated ovariectomy-induced weight gain and decreased accumulation of visceral fat tissue. It counteracted adipokines imb ...
body composition; bone density; bone mineralization; calcium; diet; dual-energy X-ray absorptiometry; gilts; growth performance; phosphorus; repletion
Abstract:
... This study investigated the ability of replacement gilts to adapt their calcium and phosphorus utilization and their kinetics in bone mineralization to compensate for modified intake of these nutrients by applying a novel Ca and P depletion and repletion strategy. A total of 24 gilts were fed according to a two-phase feeding program. In the first phase, gilts (60–95 kg BW) were fed ad libitum a de ...
... Periodontitis, one of the most common oral complications of diabetes mellitus (DM), causes a reduction in alveolar bone height and loss of alveolar bone mass. It has been shown that DM aggravates the progression of periodontitis, but the mechanism remains inconclusive. The hyperglycemic environment of DM has been proven to generate reactive oxygen species (ROS). Since telomeres, guanine-rich repea ...
... Catch-up growth is a process that promotes weight and height gains to recover normal growth patterns after a transient period of growth inhibition. Accelerated infant growth is associated with reduced bone mass and quality characterized by poor bone mineral density (BMD), content (BMC), and impaired microarchitecture. The present study evaluated the effects of a diet containing slow (SDC) or rapid ...
alkaline phosphatase; average daily gain; biotechnology; blood serum; bone density; cages; calcium; dietary calcium; genes; growth performance; males; phosphorus content; protein synthesis; skeletal development; tibia
Abstract:
... BACKGROUND: The current calcium (Ca) recommendation for broilers is primarily based on studies conducted more than 30 years ago with birds of markedly different productive potentials from those which exist today. And the response indicators in these studies are mainly growth performance and bone ash percentage. Therefore, the present study was carried out to investigate the effect of dietary Ca le ...
RNA; ammonium; bioinformatics; bone density; bone formation; citrates; diabetes mellitus; divalent metals; endocrinology; glucose; high fat diet; intraperitoneal injection; iron overload; mice; mineralization; osteoblasts; osteoporosis; oxidative stress; pathogenesis; prediction; streptozotocin; therapeutics; viability
Abstract:
... Diabetic osteoporosis (DOP) is a complication of diabetes mellitus (DM) and occurs due to alterations in bone metabolism under hyperglycemic condition. ELAV-like RNA binding protein 1 (ELAVL1) is abnormally up-regulated in diabetes-related diseases. Bioinformatics prediction indicates that divalent metal transporter 1 (DMT1) is a potential target of ELAVL1. To explore the role of ELAVL1 and the in ...
bone density; cartilage; chondrocytes; femur; hypertrophy; research
Abstract:
... Chondrocyte hypertrophy is a significant factor in cartilage development, yet the molecular mechanism for cell volume expand during the process is remains unclear. In the present study, the relationship between Swell1, a cell volume regulated anion channel, and chondrocyte hypertrophy was explored. The results reveal that the spatiotemporal expression of Swell1 was similar with the development pro ...
25-hydroxycholecalciferol; agriculture; average daily gain; blood serum; bone density; bone resorption; collagen; digestibility; feed conversion; femur; growth performance; osteocalcin; phytases; skeletal development
Abstract:
... BACKGROUND: The beneficial function of phytase and 25‐hydroxyvitamin D3 (HyD) on the feed utilization rate has been widely investigated. However, studies concerning its influence on weaned piglets largely lag behind. The aim of this study was to investigate the effects of phytase and HyD supplementation on the growth performance and bone development in weaned piglets under dietary Ca and P deficie ...
absorption; bone density; bone health; calcium; calcium deficiency; chromatography; cytotoxicity; dietary calcium; genotoxicity; histology; ionization; microstructure; mutagens; solubility
Abstract:
... Ionic calcium can help in the prevention of the process of osseous decalcification. This study aimed to evaluate the physicochemical properties and toxic effects of ionic calcium-fiber supplement (ICa⁺) and its impact on bone health preservation in mice C57/BL6 fed a calcium-deficient diet. Physicochemical properties include FTIR, apparent calcium solubility estimated by the calcium ratio obtained ...
adipogenesis; adiposity; antagonists; apoptosis; biocompatible materials; bone density; bone formation; bone resorption; mice; osteoporosis; therapeutics
Abstract:
... Recent investigations into mechanisms behind the development of osteoporosis suggest that suppressing PPARγ-mediated adipogenesis can improve bone formation and bone mineral density. In this study, we investigated a co-treatment strategy to enhance bone formation by combining NELL-1, an osteogenic molecule that has been extensively studied for its potential use as a therapeutic for osteoporosis, w ...
bone density; bone formation; cartilage; gene expression; glucosamine; glycosaminoglycans; health foods; humans; mineralization; neural crest; osteoblasts; osteopontin; osteoporosis; research; skeleton
Abstract:
... The stepwise development of bone is rigidly controlled from mesenchymal cells through osteoblasts. Dysregulation of this process causes various bone diseases, such as osteoporosis and osteogenesis imperfecta. Recently, it has been noted that the decrease in bone density due to aging occurs not only in the axial skeleton but also in the facial bone. To address this issue, we focused on neural crest ...
bone density; eosin; genomics; goats; growth and development; longissimus muscle; meat production; meat quality; muscle development; muscle fibers; non-coding RNA; phenotype; sequence analysis; skeletal muscle; China
Abstract:
... Circular RNAs (circRNAs) are a class of non-coding RNA that play crucial roles in the growth and development of skeletal muscle. However, little is known about the role of circRNAs in caprine skeletal muscle. In this study, the size of muscle fiber and the expression profiles of circRNAs were compared in Longissimus dorsi muscle of Liaoning cashmere (LC) goats and Ziwuling black (ZB) goats with si ...
J. Fernández-Torres; Y. Zamudio-Cuevas; G. A. Martínez-Nava; O. G. Aztatzi-Aguilar; M. P. Sierra-Vargas; C. A. Lozada-Pérez; C. Suárez-Ahedo; C. Landa-Solís; A. Olivos-Meza; L. M. Del Razo; M. C. Camacho-Rea; K. Martínez-Flores
blood; bone density; bone resorption; cadmium; cartilage; inflammation; lung neoplasms; osteoarthritis; osteoporosis; oxidative stress; research; rheumatoid arthritis; smoke; tobacco; tobacco use; toxicity; trace elements
Abstract:
... Tobacco use has a negative impact on health due to its relationship with the development of high-mortality diseases, such as pulmonary cancer. However, the effect of cadmium (Cd), present in tobacco smoke, on the development of joint diseases has been scarcely studied. The objective of this review is to discuss the evidence regarding the mechanisms by which Cd exposure, through tobacco smoke, may ...
Jesús F. García-Gavilán; Indira Paz-Graniel; Nancy Babio; Dora Romaguera; Jose Alfredo Martínez; Vicente Martin; María Ángeles Martínez; Jadwiga Konieczna; Miguel Ruiz-Canela; José Antonio de Paz Fernandez; Albert Goday; Miguel Ángel Martínez-González; Mònica Bulló; Jordi Salas-Salvadó
bone density; bone metabolism; cross-sectional studies; dual-energy X-ray absorptiometry; femur; food frequency questionnaires; inflammation; lumbar spine; metabolic syndrome; obesity; osteopenia; osteoporosis; regression analysis
Abstract:
... PURPOSE: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. METHODS: Base ...
Gadus morhua; acid phosphatase; bone density; bone formation; bone resorption; dietary supplements; economic valuation; nutritive value; osteoclasts; osteoporosis; ovariectomy; peptides; resorption
Abstract:
... Atlantic cod (Gadus morhua) is one of the most important fishes in the world with high nutritional value and economic value. However, the impact and underlying mechanism of the G. morhua peptides (GMPs) on osteoclastogenesis and bone mineral density (BMD) regulation remain unclear. The purpose of this study was to investigate the effects of GMPs on osteoclast formation and anti-osteoporosis activi ...
anisotropy; bone density; cartilage; computed tomography; data collection; ultrasonics; young adults
Abstract:
... Mandibular condyle (MC) in postnatal life, grows mainly by endochondral bone growth which is a multistep process and the condylar cartilage plays a vital role in its regional adaptive growth. Hence, for determining the exact effect of a treatment such as low Intensity pulsed ultrasound (LIPUS) on the MC growth in animal models, it is important to reliably and reproducibly detect changes at differe ...
National Health and Nutrition Examination Survey; body mass index; body weight; bone density; cadmium; diabetes; femur; gender; hormone replacement therapy; kidney diseases; lead; lean body mass; menopause; models; nationalities and ethnic groups; osteoporosis; physical activity; prednisone; regression analysis; research; risk; risk assessment
Abstract:
... We developed an association model to estimate the risk of femoral neck low bone mass and osteoporosis from exposure to cadmium for women and men aged 50–79 in the U.S, as a function of the urinary cadmium (U–Cd) levels. We analyzed data from the NHANES 2005–2014 surveys and evaluated the relationship between U–Cd and femoral neck bone mineral density (BMD) using univariate and multivariate regress ...
adrenergic receptors; blood; bone density; bone resorption; brain; calmodulin; collagen; corticosterone; corticotropin; corticotropin-releasing hormone; crosslinking; energy intake; glucocorticoid receptors; ligands; neurons; omega-3 fatty acids; ovariectomy; postmenopause; serotonin
Abstract:
... Depression induced by chronic mild stress (CMS) reduced bone mass in ovariectomized (OVX) rats, and maternal separation (MS) during early life aggravated depression-induced bone mass destruction. N-3 polyunsaturated fatty acids (PUFA) have been shown to improve bone mass and depression, but the bone-protecting effects of n-3 PUFA were unclear in CMS+MS-induced depression models. The purpose of thi ...
body fat; bone density; bone metabolism; clinical nutrition; dual-energy X-ray absorptiometry; functional status; glomerular filtration rate; hand strength; kidney diseases; muscles; observational studies; osteopenia; osteoporosis; regression analysis; skeletal muscle
Abstract:
... Chronic kidney disease (CKD) is associated with a reduction in bone mineral density (BMD), but less is understood regarding the relation between BMD and muscle mass, especially in non-dialysis dependent-CKD (NDD-CKD). The aim of this study was to explore the prevalence and association of low BMD (osteopenia and osteoporosis) with markers of muscle mass and function in patients with NDD-CKD. This c ...
... Bitter acids (BA) from Humulus lupulus L. (hops) are known for beer brewing and have been proved to have activities on reliving oxidative stress and osteoporosis. This study firstly determined the effects of BA on senile osteoporosis (SOP) in D-galactose induced aging mice. BA significantly increased femoral bone mineral density, serum levels of alkaline phosphatase, osteocalcin as well as decreas ...
... Objectives: Skeletal muscle loss and osteoporosis are major medical and socioeconomic concerns as the global population ages. Studies have reported that skeletal muscle mass correlates to bone mineral density (BMD). The psoas muscle index (PMI), measured as the L3 cross-sectional areas of the right and left psoas divided by the square of height, has a positive correlation with the total volume of ...
alkaline phosphatase; animal injuries; biophysics; bone density; bone formation; bone resorption; collagen; femur; ligands; microRNA; mineralization; osteoblasts; osteoporosis
Abstract:
... Osteoporosis is a common complication accompanied by spinal cord injury (SCI) occurrence. MicroRNAs (miRNAs) have been proved to play a crucial role in the progression of osteoporosis, but their regulating mechanism is unclear. The present study investigated miRNA-19b-3p level in SCI rats induced by modified Allen method, as well as the role of miRNA-19b-3p in osteogenic differentiation of bone ma ...
... Serum total and free calcium reflect the status of the body health and disease. Smoking is risk factor for many diseases as cardiovascular, lung, and cancers. The goal of this work is to evaluate the correlation between serum lead, cadmium arsenate resulting from passive smoking, and bone status in females. This study was conducted on two hundred women (age 30–50 years) divided into four groups (e ...
Luling Lin; Greg D. Gamble; Caroline A. Crowther; Frank H. Bloomfield; Massimo Agosti; Stephanie A. Atkinson; Augusto Biasini; Nicholas D. Embleton; Fernando Lamy Filho; Christoph Fusch; Maria L. Gianni; Hayriye Gözde Kanmaz Kutman; Winston Koo; Ita Litmanovitz; Colin Morgan; Kanya Mukhopadhyay; Erica Neri; Jean-Charles Picaud; Niels Rochow; Paola Roggero; Kenneth Stroemmen; Maw J. Tan; Francesco M. Tandoi; Claire L. Wood; Gitte Zachariassen; Jane E. Harding
bone density; childhood; cognitive disorders; infancy; males; meta-analysis; risk; small for gestational age
Abstract:
... Neonatal nutritional supplements may improve early growth for infants born small, but effects on long-term growth are unclear and may differ by sex. We assessed the effects of early macronutrient supplements on later growth. We searched databases and clinical trials registers from inception to April 2019. Participant-level data from randomised trials were included if the intention was to increase ...
Bivalvia; acid phosphatase; alkaline phosphatase; amino acids; biomineralization; bone density; bone formation; glycoproteins; osteoblasts; osteocalcin; osteoporosis; oysters; shellfish; water solubility
Abstract:
... Matrix protein is secreted by the membrane of bivalve shellfish to and used to regulate shell biomineralization. In this study, we extracted water-soluble matrix protein (WSMP) from oyster shells to investigate its effects on osteogenic differentiation and mineralization of MC3T3-E1 cells and osteoporosis rats. Our results suggested that WSMP was an acidic glycoprotein by amino acid analysis and s ...
acid phosphatase; alkaline phosphatase; bone density; bone strength; females; femur; gait; osteocalcin; oxytocin; peroxidation; porosity; superoxide dismutase
Abstract:
... This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days afte ...
... Heat stress (HS) negatively impacts animal production worldwide, being an economic and welfare issue. In poultry, HS was shown to reduce feed intake and increase mineral excretion, suggesting a marginal mineral deficiency. The objective was to assess the response of Azomite, a dacitic (rhyolitic) tuff breccia (DTB), on performance, antioxidant system, gut health, inflammation, and bone characteris ...
Chinese people; Toxoplasma gondii; ancestry; blood; bone density; case-control studies; computer software; females; femur; males; medical records; models; noninsulin-dependent diabetes mellitus; osteopenia; osteoporosis; regression analysis; risk factors; risk reduction
Abstract:
... BACKGROUND: More than one-third of the total world population is infected by Toxoplasma gondii (T. gondii). T. gondii has been linked to various diseases, such as cancer, mental disorders, type 2 diabetes mellitus (T2DM), etc. However, the effects of T. gondii infection on the risk of osteoporosis are unclear. Our study aimed to uncover evidence to determine whether patients exposed to T. gondii h ...
25-hydroxycholecalciferol; T-lymphocytes; ambient temperature; biotechnology; blood serum; bone density; bone formation; bone health; bone marrow; bone resorption; cathepsin K; collagen; crosslinking; dysbiosis; heat; heat stress; ileum; inflammation; mineral content; osteoclasts; permeability; therapeutics; tibia
Abstract:
... BACKGROUND: Alterations in ambient temperature have been associated with multiple detrimental effects on broilers such as intestinal barrier disruption and dysbiosis resulting in systemic inflammation. Inflammation and 25-hydroxycholecalciferol (25-OH-D₃) have shown to play a negative and positive role, respectively, in the regulation of bone mass. Hence the potential of 25-OH-D₃ in alleviating he ...
Thoroughbred; anisotropy; body size; bone density; exercise; gender; micro-computed tomography; morphometry; necropsy; veterinary medicine
Abstract:
... Proximal sesamoid bone (PSB) injuries account for approximately 50% of fatal catastrophic musculoskeletal injuries in Thoroughbred racehorses. In addition, PSB fractures are not uncommon in Thoroughbred foals and yearlings as a result of energetic or intense free exercise. The ability to interpret some PSB pathology assessments, however, is more difficult given the limited information published on ...
animal nutrition; blood serum; bone density; bone mineralization; calcium; diet history; dual-energy X-ray absorptiometry; growth and development; hypocalcemia; lameness; males; malnutrition; osteopenia; phosphorus; puppies; raw meat; surveys; therapeutics; vitamin D
Abstract:
... A 4‐month‐old male Old English Sheepdog was presented for evaluation of a raw meat‐based homemade diet after a 1‐month history of progressive lameness. Marked dietary deficiencies were detected, which included calcium, phosphorus and vitamin D. Hypovitaminosis D and hypocalcaemia were diagnosed by serum analysis. Evidence of severe diffuse osteopenia was noted on survey radiographs. Dual‐energy X‐ ...
adults; biocompatible materials; bone density; bone formation; bone resorption; females; fluorescent dyes; homeostasis; males; models; ovariectomy; parathyroid hormone; rats; tibia
Abstract:
... Activation of modeling-based bone formation (MBF - bone formation without prior activation of bone resorption), has been identified as an important mechanism by which anabolic agents, such as intermittent parathyroid hormone (PTH), rapidly elicit new bone formation. Using a novel cryohistology imaging platform, coupled with sequential multicolor fluorochrome injections, we demonstrated that MBF an ...
absorption; body weight; bone density; cadmium; diet; egg production; egg shell quality; equipment; feed intake; heavy metals; liver; pollution; poultry; poultry feed; selenium; toxicity; toxicology
Abstract:
... Cadmium (Cd) is a toxic heavy metal, discharged into environments naturally or anthropogenically, where industrial and agricultural revolutions have led to serious Cd pollution into the environment. Poultry feed may be contaminated by Cd due to its presence in concentrates and supplements, and also in the machinery and equipment used in feed production and processing. After absorption in the diges ...
antioxidants; biogenesis; bone density; bone formation; bone resorption; drugs; epigenetics; histones; homeostasis; inflammation; methylation; mineralization; mitochondria; mitochondrial DNA; osteoblasts; osteoporosis; oxidative phosphorylation; research; sulfides
Abstract:
... Age-associated bone loss or osteoporosis is a common clinical manifestation during aging (AG). The mechanism underlying age-associated osteoblast dysfunction induced by oxidative damage in the mitochondria and loss of bone density remains elusive. Here, we demonstrated the effect of allyl sulfide (AS), a natural organosulfur compound, on mitochondrial (mt) function in bone marrow-derived mesenchym ...
adolescence; bioelectrical impedance; body composition; body mass index; bone density; dietary calcium; energy intake; males; models; physical activity; puberty; regression analysis; secondary education; sedentary lifestyle; ultrasonics; China
Abstract:
... Background: Bone mineral acquisition during adolescence is crucial for maximizing peak bone mass. Fat mass (FM) and bone mass are closely related. This study investigated the association of FM distribution with bone mass in Chinese male adolescents. Method: A total of 693 male adolescents aged 10–18 years were recruited from a secondary school in Jiangmen, China. Their bone mass and body compositi ...
body composition; body weight; bone density; cross-sectional studies; males; muscle tissues; sand; sports; ultrasonics
Abstract:
... Background: Beach handball is a recent team sport characterized by defensive and offensive actions on a sand surface. Scientific evidence has shown that body composition is fundamental in sports performance. The main objective of this study was to know the body composition, anthropometric characteristics, and bone mineral density of elite beach handball players. Furthermore, another purpose was to ...
alkaline phosphatase; amino acid composition; biomechanics; blood serum; bone density; calcium; gel chromatography; hydrolysis; in vitro digestion; microstructure; models; molecular weight; osteoporosis; peptides; phosphates; phosphorus; protein content; protein hydrolysates; rats; reversed-phase high performance liquid chromatography; walnuts
Abstract:
... The walnut protein hydrolysate (WPH) was prepared via simulated gastrointestinal digestion. The degree of hydrolysis (DH), amino acid composition, and relative molecular weight distribution of WPH were analyzed. The results showed that the DH of WPH was 11.6%, WPH was rich in Glu and Pro, and the relative average molecular weight of 572 Da accounted for 59.78%. The effects of WPH on osteoporosis w ...
alleles; bioavailability; blood serum; bone density; bone health; bone metabolism; cohort studies; genotyping; haplotypes; homozygosity; postmenopause; vitamin D-binding protein
Abstract:
... Vitamin D-binding protein (VDBP) is encoded by the GC gene and is an active participant in the control of bone metabolism. However, the effect of its major variants on VDBP concentration and bone mineral density (BMD) remains unclear. Our aim was to analyze the effect of major GC variants on serum VDBP concentration and BMD. We recruited individuals from the Health Workers Cohort Study, which incl ...
bone density; femur; genes; genetic predisposition to disease; genotype; hips; interleukin-10; osteoporosis; postmenopause; risk; single nucleotide polymorphism
Abstract:
... Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/ ...
National Health and Nutrition Examination Survey; arsenic; blood; body mass index; bone density; bone health; bone resorption; cadmium; humans; models; osteoporosis; prediction; public health; research; tungsten; urine
Abstract:
... Osteoporosis and its consequence of fragility fracture represent a major public health problem. Human exposure to heavy metals has received considerable attention over the last decades. However, little is known about the influence of co-exposure to multiple heavy metals on bone density. The present study aimed to examine the association between exposure to metals and bone mineral density (BMD) los ...
air pollutants; air pollution; basal metabolic rate; bioelectrical impedance; bone density; confidence interval; environment; environmental protection; lean body mass; muscle tissues; oxygen; particulates; sleep; sleep apnea; Taiwan
Abstract:
... This study aims to investigate the association of air pollution with overnight change in 4body composition and sleep-related parameters. Body composition of 197 subjects in New Taipei city was measured before and after sleep by bioelectric impedance analysis. Air pollutant data were collected from Taiwan Environmental Protection Administration. Sleep parameters were examined by polysomnography. We ...
body fat; bone density; exercise; femur; food science; hips; lean body mass; low calorie diet; lumbar spine; mass density; meta-analysis; postmenopause; systematic review; therapeutics; weight control; weight loss
Abstract:
... Background: A major therapeutic goal in weight management should be total body fat reduction whereas as preserving lean body mass and bone mass density. It is uncertain if an exercise program reduces the adverse effects of calorie restriction-induced weight loss in adults. Objective: The aim of the present study was to evaluate the differences in bone mass between adults who enrolled in a calorie ...