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- Author:
- Rong Zhang; Shi-Jie Hu; Chen Li; Feng Zhang; Hong-Quan Gan; Qi-Bing Mei
- Source:
- Journal of ethnopharmacology 2012 v.139 no.1 pp. 12-18
- ISSN:
- 0378-8741
- Subject:
- Achyranthes japonica; alkaline phosphatase; alternative medicine; biomarkers; bone density; bone resorption; bone strength; calcium; dual-energy X-ray absorptiometry; excretion; micro-computed tomography; oral administration; osteocalcin; osteoporosis; ovariectomy; phosphorus; rats; uterus; weight gain
- Abstract:
- ... AIM: The objective of the present study was to systematically investigate the effects of Achyranthes bidentata root extract (ABRE) on postmenopausal osteoporosis. MATERIALS AND METHODS: Eighty 3-month-old female Sprague–Dawley rats were used and randomly assigned into sham-operated group (SHAM) and five ovariectomy (OVX) subgroups, i.e. OVX with vehicle (OVX); OVX with 17β-ethinylestradiol (E₂, 25 ...
- DOI:
- 10.1016/j.jep.2011.05.034
- PubMed:
- 21669273
- https://doi.org/10.1016/j.jep.2011.05.034
- Author:
- Ivy L Mak; Paula Lavery; Sherry Agellon; Frank Rauch; Monzur Murshed; Hope A Weiler
- Source:
- Journal of nutritional biochemistry 2019 v.73 pp. 108226
- ISSN:
- 0955-2863
- Subject:
- adipocytes; adiposity; analysis of variance; arachidonic acid; blood serum; bone density; bone resorption; bone strength; dual-energy X-ray absorptiometry; energy intake; erythrocytes; fatty acid composition; femur; gas chromatography; high fat diet; laboratory animals; leptin; long chain polyunsaturated fatty acids; males; metabolism; micro-computed tomography; mineral content; obesity; rats; visceral fat
- Abstract:
- ... Long-chain polyunsaturated fatty acids modulate bone mass and adipocyte metabolism. Arachidonic acid (AA, C20:4 n-6) is elevated in obesity and postulated to stimulate bone resorption. This study aimed to determine the effect of AA on bone mass, quality, and adiposity in diet-induced obesity during growth. Male Sprague–Dawley rats (n=42, 4-week) were randomized into groups fed a control diet (CTRL ...
- DOI:
- 10.1016/j.jnutbio.2019.108226
- https://doi.org/10.1016/j.jnutbio.2019.108226
- Author:
- Yanmao Wang; Yu Zhu; Shengdi Lu; Chengfang Hu; Wanrun Zhong; Yimin Chai
- Source:
- Biochemical and biophysical research communications 2018 v.498 no.4 pp. 981-987
- ISSN:
- 0006-291X
- Subject:
- adverse effects; biomechanics; blood lipids; blood serum; bone density; bone metabolism; bone strength; chemical constituents of plants; femur; high fat diet; hyperlipidemia; lipid composition; low density lipoprotein cholesterol; medicinal properties; micro-computed tomography; osteoblasts; osteoporosis; protective effect; rats; risk factors; triacylglycerols
- Abstract:
- ... Osteoporosis is linked to reduced bone mineral density (BMD) as a major risk factor for fragility fractures. Recent studies indicated an association between BMD and abnormally elevated lipid levels in blood as common indicators for hyperlipidemia. In this study, we assessed the protective effect of paeoniflorin, a phytochemical compound with multiple pharmacological activities, against hyperlipide ...
- DOI:
- 10.1016/j.bbrc.2018.03.093
- https://doi.org/10.1016/j.bbrc.2018.03.093
- Author:
- Han Seok Yoo; Gyung-Ji Kim; Da Hye Song; Kang-Hyun Chung; Kwon-Jai Lee; Dong-Hee Kim; Jeung Hee An
- Source:
- Nutrients 2017 v.9 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- Gallus gallus; bone density; bone formation; bone morphogenetic proteins; bone resorption; bone strength; calcium; cathepsin K; chickens; diet; genes; genetic markers; micro-computed tomography; mitogen-activated protein kinase; mothers against decapentaplegic homolog proteins; osteoblasts; osteocalcin; osteoclasts; ovariectomy; rats; tibia; transcription factor NF-kappa B
- Abstract:
- ... The present study evaluated the effects of a calcium (Ca) supplement derived from Gallus gallus domesticus (GD) on breaking force, microarchitecture, osteogenic differentiation and osteoclast differentiation factor expression in vivo in Ca-deficient ovariectomized (OVX) rats. One percent of Ca supplement significantly improved Ca content and bone strength of the tibia. In micro-computed tomography ...
- DOI:
- 10.3390/nu9050504
- PubMed:
- 28513557
- PubMed Central:
- PMC5452234
- https://doi.org/10.3390/nu9050504
- Author:
- Fan Zhang; Shokouh Attarilar; Kegong Xie; Chao Han; Qingyang liang; Ke Huang; Changgong Lan; Chong Wang; Chengliang Yang; Liqiang Wang; Masoud Mozafari; Kai Li; Jia Liu; Yujin Tang
- Source:
- Molecular and cellular endocrinology 2022 v.540 pp. 111520
- ISSN:
- 0303-7207
- Subject:
- bone density; bone formation; bone strength; endocrinology; micro-computed tomography; models; osteoblasts; osteoclasts; osteoporosis; ovariectomy; postmenopause; proteasome endopeptidase complex; proteasome inhibitors; protein content; recombinant proteins
- Abstract:
- ... Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in OP, an ...
- DOI:
- 10.1016/j.mce.2021.111520
- https://doi.org/10.1016/j.mce.2021.111520
- Author:
- B.M. Harvey; M. Eschbach; E.A. Glynn; S. Kotha; M. Darre; D.J. Adams; R. Ramanathan; R. Mancini; K.E. Govoni
- Source:
- Poultry science 2015 v.94 no.2 pp. 296-301
- ISSN:
- 0032-5791
- Subject:
- blood serum; body weight; bone density; bone strength; color; feed intake; femur; lipid peroxidation; lithium; lithium chloride; meat quality; mice; micro-computed tomography; modulus of elasticity; muscles; pectoralis muscle
- Abstract:
- ... The objective was to determine the effects of oral lithium chloride supplementation on bone strength and mass in broiler chickens. Ninety-six broilers were assigned to 1 of 2 treatment groups (lithium chloride or control; n = 48/treatment). Beginning at 1 or 3 wk of age, chickens were administered lithium chloride (20 mg/kg body weight) or water daily by oral gavage. At 6 wk of age, chickens were ...
- DOI:
- 10.3382/ps/peu079
- https://doi.org/10.3382/ps/peu079
- Author:
- Xiufeng Tang; Yingying Gao; Yuheng Chen; Xiaoxi Li; Ping Yu; Zitong Ma; Renhui Liu
- Source:
- Food & function 2019 v.10 no.12 pp. 8026-8041
- ISSN:
- 2042-650X
- Subject:
- Western blotting; acid phosphatase; alkaline phosphatase; biomechanics; blood serum; bone density; bone metabolism; bone strength; calcium; cholecalciferol; drugs; fluorescent antibody technique; insulin-like growth factor I; laboratory animals; macrophage colony-stimulating factor; males; messenger RNA; micro-computed tomography; microstructure; models; osteoporosis; pathogenesis; protein synthesis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; tibia; transforming growth factor beta 1
- Abstract:
- ... Senile osteoporosis (SOP) is a related disease of systematic degenerative changes in bones during natural aging. Increasing age is an important factor in its pathogenesis. This experiment was to evaluate the comprehensive effect of calcium with vitamin D3 (CaD) on SOP based on multilayer perception (MLP)–artificial neural network (ANN) methods. 15-month-old male Sprague-Dawley rats were administer ...
- DOI:
- 10.1039/c9fo01322a
- https://doi.org/10.1039/c9fo01322a
- Author:
- Marcin R. Tatara; Witold Krupski; Anna Charuta; Adam Brodzki; Artur Jóźwik; Nina Strzałkowska; Ewa Poławska; Krzysztof Chmielowiec; Jarosław O. Horbańczuk
- Source:
- Poultry science 2016 v.95 no.10 pp. 2421-2426
- ISSN:
- 0032-5791
- Subject:
- Struthio camelus; animal morphology; bone density; bone mineralization; bone strength; densitometry; dual-energy X-ray absorptiometry; females; femur; mechanical properties; metatarsus; micro-computed tomography; mineral content; ostriches; pelvic bones; tibia
- Abstract:
- ... Limited information on physiological characteristic of bones in ostrich skeleton are available, even though bone weaknesses in ostriches are commonplace. Thus, the aim of this study was to evaluate morphological, densitometric, and mechanical properties of pelvic limb long bones (femur, tibia, and tarsometatarsus) in 14-month-old female ostriches (Struthio camelus var. domesticus). After the slaug ...
- DOI:
- 10.3382/ps/pew188
- https://doi.org/10.3382/ps/pew188
- Author:
- Radoslaw Piotr Radzki; Marek Bienko; Dariusz Wolski; Monika Ostapiuk; Pawel Polak; Malgorzata Manastyrska; Aleksandra Kimicka; Joanna Wolska
- Source:
- Animals 2021 v.11 no.2 pp. -
- ISSN:
- 2076-2615
- Subject:
- blood serum; bone density; bone metabolism; bone strength; dual-energy X-ray absorptiometry; females; high energy diet; males; micro-computed tomography; mineralization; obesity; progeny; rats; strength (mechanics); tibia
- Abstract:
- ... Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group ...
- DOI:
- 10.3390/ani11020424
- https://doi.org/10.3390/ani11020424
- Author:
- Kirsten N. Bott; Sandra M. Sacco; Patrick C. Turnbull; Amanda B. Longo; Wendy E. Ward; Sandra J. Peters
- Source:
- Applied Physiology, Nutrition, and Metabolism 2016 v.41 no.6 pp. 597-604
- ISSN:
- 1715-5320
- Subject:
- bone density; bone strength; dual-energy X-ray absorptiometry; food intake; males; mandible (bone); mastication; materials testing; metabolism; micro-computed tomography; rats; skeleton; tibia; vertebrae
- Abstract:
- ... Bone microarchitecture, bone mineral density (BMD), and bone strength are affected positively by impact activities such as running; however, there are discrepancies in the magnitude of these effects. These inconsistencies are mainly a result of varying training protocols, analysis techniques, and whether or not the skeletal sites measured are weight bearing. This study’s purpose was to determine t ...
- DOI:
- 10.1139/apnm-2015-0404
- https://doi.org/10.1139/apnm-2015-0404
- Author:
- Yufeng Zhang; Lingfei Wei; Jiang Chang; Richard J. Miron; Bin Shi; Siqi Yi; Chengtie Wu
- Source:
- Journal of materials chemistry B 2013 v.1 no.41 pp. 5711-5722
- ISSN:
- 2050-7518
- Subject:
- bioactive properties; biocompatible materials; blood; bone density; bone formation; bone fractures; bone resorption; bone strength; calcium; chemistry; collagen; eosin; excretion; femur; glass; immunohistochemistry; in vitro culture; ions; mesenchymal stromal cells; micro-computed tomography; osteoblasts; osteoporosis; ovariectomy; phenotype; porous media; quantitative polymerase chain reaction; rats; silicon; staining; strontium; urine
- Abstract:
- ... Osteoporosis is one of the most widely occurring bone disorders characterized by low bone mineral density and poor bone strength. Strontium ranelate, as a treatment option, has received significant attention in recent years due to its ability to halt the progress of osteoporosis by simultaneously improving bone formation and reducing bone resorption. Although much emphasis has been given to the tr ...
- DOI:
- 10.1039/c3tb21047b
- https://doi.org/10.1039/c3tb21047b
- Author:
- Tae-Ho Kim; Ji Won Jung; Byung Geun Ha; Jung Min Hong; Eui Kyun Park; Hyun-Ju Kim; Shin-Yoon Kim
- Source:
- Journal of nutritional biochemistry 2011 v.22 no.1 pp. 8-15
- ISSN:
- 0955-2863
- Subject:
- animal models; anti-inflammatory activity; biomarkers; bone density; bone marrow; bone resorption; bone strength; femur; luteolin; mice; micro-computed tomography; mineral content; oral administration; osteoclasts; osteoporosis; postmenopause; surgery
- Abstract:
- ... Flavonoids, a group of polyphenolic compounds abundant in plants, are known to prevent bone loss in ovariectomized (OVX) animal models. Inhibition of osteoclast differentiation and bone resorption is considered as an effective therapeutic approach in the treatment of postmenopausal bone loss. Luteolin, a plant flavonoid, has potent anti-inflammatory properties both in vivo and vitro. In this study ...
- DOI:
- 10.1016/j.jnutbio.2009.11.002
- PubMed:
- 20233653
- https://doi.org/10.1016/j.jnutbio.2009.11.002
- Author:
- Yi Pei; Ke Zheng; GuanNing Shang; YuMing Wang; Wei Wang; EnDuo Qiu; ShenLong Li; XiaoJing Zhang
- Source:
- Biological trace element research 2019 v.187 no.2 pp. 472-481
- ISSN:
- 0163-4984
- Subject:
- acid phosphatase; alkaline phosphatase; animal models; biomechanics; blood sampling; blood serum; bone density; bone formation; bone resorption; bone strength; calcium; cyclophosphamide; diet; intravenous injection; laboratory animals; males; micro-computed tomography; osteoblasts; osteoclasts; osteopenia; osteoporosis; phosphates; rats; strontium; tibia
- Abstract:
- ... The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-five Sprague-Dawley male rats were randomly assigned to three study groups (n = 15 rats per group): normal rats (control group), osteopenic rats (chemo group), and osteopenic rats with SrR (c ...
- DOI:
- 10.1007/s12011-018-1401-3
- https://doi.org/10.1007/s12011-018-1401-3