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You searched for: Subject term bone strength Remove constraint Subject term: bone strength Subject term bone density Remove constraint Subject term: bone density
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1. Carfilzomib alleviated osteoporosis by targeting PSME1/2 to activate Wnt/β-catenin signaling

Author:
Fan Zhang; Shokouh Attarilar; Kegong Xie; Chao Han; Qingyang liang; Ke Huang; Changgong Lan; Chong Wang; Chengliang Yang; Liqiang Wang; Masoud Mozafari; Kai Li; Jia Liu; Yujin Tang
Source:
Molecular and cellular endocrinology 2022 v.540 pp. 111520
ISSN:
0303-7207
Subject:
bone density; bone formation; bone strength; endocrinology; micro-computed tomography; models; osteoblasts; osteoclasts; osteoporosis; ovariectomy; postmenopause; proteasome endopeptidase complex; proteasome inhibitors; protein content; recombinant proteins
Abstract:
... Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in OP, an ...
DOI:
10.1016/j.mce.2021.111520

2. Effects of 12 Months Consumption of 100 g Dried Plum (Prunes) on Bone Biomarkers, Density, and Strength in Men

Author:
Shirin Hooshmand; Danielle Gaffen; Ashley Eisner; Jonnatan Fajardo; Mark Payton; Mark Kern
Source:
Journal of medicinal food 2022 v.25 no.1 pp. 40-47
ISSN:
1557-7600
Subject:
alkaline phosphatase; biomarkers; blood; bone density; bone health; bone strength; collagen; computed tomography; diet; dual-energy X-ray absorptiometry; functional foods; hips; humans; males; plums; prunes; tibia; ulna
Abstract:
... Several male animal studies have demonstrated bone-protective effects of dried plum; however, no human male study has evaluated the effect of dried plum on bone health. We conducted a randomized controlled clinical study to test if daily inclusion of 100 g of dried plum in the diet positively influenced bone mineral density (BMD), bone strength, and bone biomarkers in men. Sixty-six men were rando ...
DOI:
10.1089/jmf.2021.0080

3. Effects of Creatine Supplementation on Properties of Muscle, Bone, and Brain Function in Older Adults: A Narrative Review

Author:
Scott C. Forbes; Darren G. Candow; Luis H. B. Ferreira; Tacito P. Souza-Junior
Source:
Journal of dietary supplements 2022 v.19 no.3 pp. 318-335
ISSN:
1939-022X
Subject:
bone density; bone strength; brain; creatine; lifestyle; muscle tissues; muscles; nitrogen
Abstract:
... Aging is associated with reductions in muscle and bone mass and brain function, which may be counteracted by several lifestyle factors, of which exercise appears to be most beneficial. However, less than 20% of older adults (> 55 years of age) adhere to performing the recommended amount of resistance training (≥ 2 days/week) and less than 12% regularly meet the aerobic exercise guidelines (≥ 150 m ...
DOI:
10.1080/19390211.2021.1877232

4. The Influence of Nesfatin-1 on Bone Metabolism Markers Concentration, Densitometric, Tomographic and Mechanical Parameters of Skeletal System of Rats in the Conditions of Established Osteopenia

Author:
Grzegorz Tymicki; Iwona Puzio; Marta Pawłowska-Olszewska; Marek Bieńko; Radosław Piotr Radzki
Source:
Animals 2022 v.12 no.5 pp. -
ISSN:
2076-2615
Subject:
alkaline phosphatase; blood serum; body weight; bone density; bone resorption; bone strength; collagen; crosslinking; densitometry; enzyme-linked immunosorbent assay; females; osteocalcin; osteopenia; ovariectomy; resorption; skeleton; tomography
Abstract:
... Our study aimed to evaluate the impact of nesfatin-1 administration on bone metabolism and properties in established osteopenia in ovariectomized female rats. In total, 21 female Wistar rats were assigned to two groups: sham-operated (SHAM, n = 7) and ovariectomized (OVA, n = 14). After 12 weeks of osteopenia induction in the OVA females, the animals were given i.p. physiological saline (OVA, n = ...
DOI:
10.3390/ani12050654

5. The action of oxytocin on the bone of senescent female rats

Author:
Luís Fernando Gadioli Santos; Fernanda Fernandes-Breitenbach; Rafael Augusto Santos Silva; Damáris Raíssa Santos; Melise Jacon Peres-Ueno; Edilson Ervolino; Antonio Hernandes Chaves-Neto; Rita Cássia Menegati Dornelles
Source:
Life sciences 2022 v.297 pp. 120484
ISSN:
0024-3205
Subject:
acid phosphatase; alkaline phosphatase; bone density; bone strength; females; femur; gait; osteocalcin; oxytocin; peroxidation; porosity; superoxide dismutase
Abstract:
... This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days afte ...
DOI:
10.1016/j.lfs.2022.120484

6. Changes of lipid and bone metabolism in broilers with spontaneous femoral head necrosis

Author:
Kangping Liu; Kuanbo Wang; Leguo Wang; Zhenlei Zhou
Source:
Poultry science 2021 v.100 no.3 pp. 100808
ISSN:
0032-5791
Subject:
alanine transaminase; alkaline phosphatase; apoptosis; aspartate transaminase; blood chemistry; bone density; bone metabolism; bone strength; cartilage; chondrocytes; comparative study; etiology; femur; growth plate; high density lipoprotein; homeostasis; hyperlipidemia; lipid metabolism; liver; liver function; necrosis; tibia; triacylglycerols
Abstract:
... Blood biochemistry and bone metabolism were evaluated to investigate the etiology and mechanism of spontaneous femoral head necrosis (FHN) in broilers. According to the femoral head score of the fourth, fifth, and sixth week old FHN-affected broilers, they were divided into 3 groups, namely Normal group, femoral head separation group, and femoral head separation with growth plate lacerations group ...
DOI:
10.1016/j.psj.2020.10.062

7. Comprehensive evaluation of the combined extracts of Epimedii Folium and Ligustri Lucidi Fructus for PMOP in ovariectomized rats based on MLP-ANN methods

Author:
Zitong Ma; Xiaoxi Li; Yuheng Chen; Xiufeng Tang; Yingying Gao; Han Wang; Renhui Liu
Source:
Journal of ethnopharmacology 2021 v.268 pp. 113563
ISSN:
0378-8741
Subject:
Oriental traditional medicine; bone density; bone strength; estrogens; humans; immunity; kidneys; metabolism; microstructure; models; nerve tissue; osteoporosis; ovariectomy; pathogenesis; postmenopause
Abstract:
... Kidney deficiency is the main pathogenesis of osteoporosis based on the theory of “kidney governing bones” in traditional Chinese medicine (TCM). Osteoporosis is a systemic disease; kidney deficiency influences the growth, aging and reproduction of human body, reflecting in endocrine, nerve, immunity, metabolism and other functions. Multi-target drugs composed of natural non-toxic products from ki ...
DOI:
10.1016/j.jep.2020.113563

8. Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes

Author:
Tsuyoshi Isojima; Natalie A. Sims
Source:
Cellular and molecular life sciences 2021 v.78 no.15 pp. 5755-5773
ISSN:
1420-682X
Subject:
bone density; bone mineralization; bone resorption; bone strength; chondrocytes; cortex; humans; mice; mineralization; osteoblasts; osteoclasts; porosity; skeletal development; wnt proteins
Abstract:
... Cortical bone structure is a crucial determinant of bone strength, yet for many years studies of novel genes and cell signalling pathways regulating bone strength have focused on the control of trabecular bone mass. Here we focus on mechanisms responsible for cortical bone development, growth, and degeneration, and describe some recently described genetic-driven modifications in humans and mice th ...
DOI:
10.1007/s00018-021-03884-w

9. Dairy Food Intake Is Not Associated with Measures of Bone Microarchitecture in Men and Women: The Framingham Osteoporosis Study

Author:
Courtney L. Millar; Douglas P. Kiel; Marian T. Hannan; Shivani Sahni
Source:
Nutrients 2021 v.13 no.11 pp. -
ISSN:
2072-6643
Subject:
bone density; bone strength; cheeses; computed tomography; cross-sectional studies; dairy consumption; energy; food frequency questionnaires; milk; osteoporosis; regression analysis; tibia; yogurt
Abstract:
... Previous studies reported that dairy foods are associated with higher areal bone mineral density (BMD) in older adults. However, data on bone strength and bone microarchitecture are lacking. We determined the association of dairy food intake (milk, yogurt, cheese, milk + yogurt, and milk + yogurt + cheese, servings/week) with high resolution peripheral quantitative computed tomography (HR-pQCT) me ...
DOI:
10.3390/nu13113940

10. Dietary betaine reduces plasma homocysteine concentrations and improves bone strength in laying hens

Author:
M. B. M. Maidin; H. A. McCormack; P. W. Wilson; S. D. Caughey; N. Whenham; I. C. Dunn
Source:
British poultry science 2021 v.62 no.4 pp. 573-578
ISSN:
1466-1799
Subject:
betaine; bone density; bone mineralization; bone strength; egg production; homocysteine; phosphorus; phytases; tibia
Abstract:
... 1. This study tested the hypothesis that the methyl-donor properties of betaine could reduce homocysteine concentrations, which has been recognised in a previous genetics study to be linked to bone quality. This was combined with phytase treatment, as phosphorus is critical for bone mineralisation. 2. Using a 2 × 2 factorial arrangement, a total of 1920 Lohmann LSL-lite chickens housed as 24 repli ...
DOI:
10.1080/00071668.2021.1883550

11. Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males

Author:
Darren G Candow; Philip D Chilibeck; Julianne Gordon; Emelie Vogt; Tim Landeryou; Mojtaba Kaviani; Lisa Paus-Jensen
Source:
Nutrition and health 2021 v.27 no.2 pp. 151-159
ISSN:
2047-945X
Subject:
bone density; bone resorption; creatine; femur; geometry; muscle strength; muscles; nutrition; placebos
Abstract:
... The combination of creatine supplementation and resistance training (10–12 weeks) has been shown to increase bone mineral content and reduce a urinary indicator of bone resorption in older males compared with placebo. However, the longer-term effects (12 months) of creatine and resistance training on bone mineral density and bone geometric properties in older males is unknown. To assess the effect ...
DOI:
10.1177/0260106020975247

12. Effect of photoperiod on eggshell quality and quality characteristics of tibia, femur, and ulna in laying ducks

Author:
Yao-ming Cui; Jing Wang; Hai-jun Zhang; Guang-hai Qi; Shu-geng Wu
Source:
Poultry science 2021 v.100 no.10 pp. 101376
ISSN:
0032-5791
Subject:
blood serum; bone density; bone formation; bone strength; egg shell; egg shell quality; femur; interleukin-6; mineral content; resorption; tibia; ulna
Abstract:
... We investigated the effect of photoperiod on eggshell quality, bone quality characteristics and bone metabolism related enzymes and factors in laying ducks. After adaption, 300 Jinding laying ducks (252-day-old) were randomly divided into 5 treatments, receiving 12L (hours of light):12D (hours of darkness), 14L:10D, 16L:8D, 18L:6D or 20L:4D, respectively. Each group had 6 replicates of 10 birds ea ...
DOI:
10.1016/j.psj.2021.101376

13. Identification and Functional Annotation of Genes Related to Bone Stability in Laying Hens Using Random Forests

Author:
Simon Jansen; Ulrich Baulain; Christin Habig; Faisal Ramzan; Jens Schauer; Armin Otto Schmitt; Armin Manfred Scholz; Ahmad Reza Sharifi; Annett Weigend; Steffen Weigend
Source:
Genes 2021 v.12 no.5 pp. -
ISSN:
2073-4425
Subject:
bone density; bone strength; humans; humerus; osteoporosis
Abstract:
... Skeletal disorders, including fractures and osteoporosis, in laying hens cause major welfare and economic problems. Although genetics have been shown to play a key role in bone integrity, little is yet known about the underlying genetic architecture of the traits. This study aimed to identify genes associated with bone breaking strength and bone mineral density of the tibiotarsus and the humerus i ...
DOI:
10.3390/genes12050702

14. Influences of lead exposure on its accumulation in organs, meat, eggs and bone during laying period of hens

Author:
Shujie Wang; Qiao Li; Yanan Gao; Zhenlei Zhou; Zhen Li
Source:
Poultry science 2021 v.100 no.8 pp. 101249
ISSN:
0032-5791
Subject:
Codex Alimentarius; body weight; bone density; bone strength; carotenoids; diet; egg albumen; egg shell; eggs; food safety; humans; humerus; kidneys; lead; liver; poultry meat; risk
Abstract:
... Elevating levels of environmental lead (Pb) results in serious hazards to health of animals and human beings. In this study, daily diet with three different levels of Pb (Pb nitrate at doses of 1, 10, and 100 mg/kg body weight) were fed to ISA Brown layers. It showed that the kidney and liver have the relatively high Pb concentration (2.34 and 0.51 ppm) after culture, while the meat has the Pb con ...
DOI:
10.1016/j.psj.2021.101249

15. Marine n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Kidney Transplant Recipients: A Randomized, Placebo-Controlled Trial

Author:
Hanne Skou Jørgensen; Ivar Anders Eide; Trond Jenssen; Anders Åsberg; Jens Bollerslev; Kristin Godang; Anders Hartmann; Erik Berg Schmidt; My Svensson
Source:
Nutrients 2021 v.13 no.7 pp. -
ISSN:
2072-6643
Subject:
adults; arms (limbs); bone density; bone resorption; bone strength; calcium; dual-energy X-ray absorptiometry; hips; kidney transplant; lumbar spine; mineral metabolism; olive oil; omega-3 fatty acids; risk
Abstract:
... Kidney transplant recipients are at high risk of progressive bone loss and low-energy fractures in the years following transplantation. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation may have beneficial effects on bone strength. The Omega-3 fatty acids in Renal Transplantation (ORENTRA) trial was an investigator initiated, randomized, placebo-controlled trial investigating the e ...
DOI:
10.3390/nu13072361

16. Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression

Author:
Gong-Jhe Wu; Kung-Yen Chen; Jr-Di Yang; Shing-Hwa Liu; Ruei-Ming Chen
Source:
Journal of agricultural and food chemistry 2021 v.69 no.44 pp. 13020-13033
ISSN:
1520-5118
Subject:
Citrus; alkaline phosphatase; bone density; bone strength; cell viability; enzyme activity; estrogen receptors; food chemistry; gene expression; humans; mice; mineralization; naringin; osteoblasts; osteoporosis; ovariectomy; plant estrogens; protein synthesis; transcriptional activation
Abstract:
... Phytoestrogens are strongly recommended for treating osteoporosis. Our previous study showed that naringin, a citrus flavonoid, can enhance the bone mass in ovariectomized rats. In this study, we further elucidated the mechanisms of naringin-induced osteoblast maturation and bone healing. Treatment of human osteoblasts with naringin increased cell viability and proliferation. In parallel, exposure ...
DOI:
10.1021/acs.jafc.1c04353

17. Non-Pharmacological Interventions in Osteosarcopenia: A Systematic Review

Author:
R. Atlihan; B. Kirk; Gustavo Duque
Source:
journal of nutrition, health & aging 2021 v.25 no.1 pp. 25-32
ISSN:
1279-7707
Subject:
at-risk population; bone density; bone metabolism; bone strength; calcium; creatine; hips; lumbar spine; mortality; muscle tissues; osteopenia; osteoporosis; placebos; risk; sarcopenia; systematic review
Abstract:
... BACKGROUND: Osteosarcopenia is a geriatric syndrome defined by the concomitant presence of osteopenia/osteoporosis (loss of bone mineral density (BMD)) and sarcopenia (loss of muscle mass and/or function), which increases the risk of falls, fractures, and premature mortality. OBJECTIVE: To examine the efficacy of non-pharmacological (exercise and/or nutritional) interventions on musculoskeletal me ...
DOI:
10.1007/s12603-020-1537-7

18. Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Author:
Radoslaw Piotr Radzki; Marek Bienko; Dariusz Wolski; Monika Ostapiuk; Pawel Polak; Malgorzata Manastyrska; Aleksandra Kimicka; Joanna Wolska
Source:
Animals 2021 v.11 no.2 pp. -
ISSN:
2076-2615
Subject:
blood serum; bone density; bone metabolism; bone strength; dual-energy X-ray absorptiometry; females; high energy diet; males; micro-computed tomography; mineralization; obesity; progeny; rats; strength (mechanics); tibia
Abstract:
... Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group ...
DOI:
10.3390/ani11020424

19. Regulation of bone phosphorus retention and bone development possibly by related hormones and local bone-derived regulators in broiler chicks

Author:
Sumei Cao; Tingting Li; Yuxin Shao; Liyang Zhang; Lin Lu; Rijun Zhang; Shuisheng Hou; Xugang Luo; Xiudong Liao
Source:
Journal of animal science and biotechnology 2021 v.12 no.1 pp. 88
ISSN:
2049-1891
Subject:
alkaline phosphatase; blood serum; bone density; bone mineralization; bone strength; broiler chickens; broiler feeding; calcitriol; chicks; fibroblast growth factors; gene expression; messenger RNA; nutrient retention; parathyroid hormone; phosphorus; proteinases; skeletal development; tibia; total phosphorus
Abstract:
... BACKGROUND: Phosphorus is essential for bone mineralization in broilers, however, the underlying mechanisms remain unclear. We aimed to investigate whether bone phosphorus retention and bone development might be regulated by related hormones and local bone-derived regulators in broilers. METHODS: Broilers were fed diets containing different levels of non-phytate phosphorus (NPP) 0.15%, 0.25%, 0.35 ...
DOI:
10.1186/s40104-021-00610-1

20. Relationship between protein intake and bone architecture or bone mineral density among dynapenic-obese older adults

Author:
Fanny Buckinx; Eva Peyrusque; Alec Bass; Philippe Noirez; Mylène Aubertin-Leheudre
Source:
Public health nutrition 2021 v.24 no.6 pp. 1291-1295
ISSN:
1475-2727
Subject:
body composition; bone density; bone strength; compression strength; gender; muscles; protein intake; public health
Abstract:
... The current study aimed to assess the relationship between protein intake and bone parameters among dynapenic-obese older adults. The current study is a secondary analysis with an a posteriori and exploratory design. Subjects were recruited from the community via social communication (flyers and meetings in community centres) in the Great Montreal area. Twenty-six subjects were divided a posterior ...
DOI:
10.1017/S1368980020005224